Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectiv...Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectively deal with nonlinearities,constraints,and noises in the system,optimize the performance metric,and present an upper bound on the stable output of the system.展开更多
This paper investigates the problem of optimal secure control for networked control systems under hybrid attacks.A control strategy based on the Stackelberg game framework is proposed,which differs from conventional m...This paper investigates the problem of optimal secure control for networked control systems under hybrid attacks.A control strategy based on the Stackelberg game framework is proposed,which differs from conventional methods by considering both denial-of-service(DoS)and false data injection(FDI)attacks simultaneously.Additionally,the stability conditions for the system under these hybrid attacks are established.It is technically challenging to design the control strategy by predicting attacker actions based on Stcakelberg game to ensure the system stability under hybrid attacks.Another technical difficulty lies in establishing the conditions for mean-square asymptotic stability due to the complexity of the attack scenarios Finally,simulations on an unstable batch reactor system under hybrid attacks demonstrate the effectiveness of the proposed strategy.展开更多
The proliferation of distributed and renewable energy resources introduces additional operational challenges to power distribution systems.Transactive energy management,which allows networked neighborhood communities ...The proliferation of distributed and renewable energy resources introduces additional operational challenges to power distribution systems.Transactive energy management,which allows networked neighborhood communities and houses to trade energy,is expected to be developed as an effective method for accommodating additional uncertainties and security mandates pertaining to distributed energy resources.This paper proposes and analyzes a two-layer transactive energy market in which houses in networked neighborhood community microgrids will trade energy in respective market layers.This paper studies the blockchain applications to satisfy socioeconomic and technological concerns of secure transactive energy management in a two-level power distribution system.The numerical results for practical networked microgrids located at IllinoisTech−Bronzeville in Chicago illustrate the validity of the proposed blockchain-based transactive energy management for devising a distributed,scalable,efficient,and cybersecured power grid operation.The conclusion of the paper summarizes the prospects for blockchain applications to transactive energy management in power distribution systems.展开更多
BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.展开更多
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o...Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.展开更多
To handle input and output time delays that commonly exist in many networked control systems(NCSs), a new robust continuous sliding mode control(CSMC) scheme is proposed for the output tracking in uncertain single inp...To handle input and output time delays that commonly exist in many networked control systems(NCSs), a new robust continuous sliding mode control(CSMC) scheme is proposed for the output tracking in uncertain single input-single-output(SISO) networked control systems. This scheme consists of three consecutive steps. First, although the network-induced delay in those systems can be effectively handled by using Pade approximation(PA), the unmatched disturbance cames out as another difficulty in the control design. Second, to actively estimate this unmatched disturbance, a generalized proportional integral observer(GPIO) technique is utilized based on only one measured state. Third, by constructing a new sliding manifold with the aid of the estimated unmatched disturbance and states, a GPIO-based CSMC is synthesized, which is employed to cope with not only matched and unmatched disturbances, but also networkinduced delays. The stability of the entire closed-loop system under the proposed GPIO-based CSMC is detailedly analyzed.The promising tracking efficiency and feasibility of the proposed control methodology are verified through simulations and experiments on Quanser's servo module for motion control under various test conditions.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the p...Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the production line,the manufacturing layer and the workshop layer.The dynamics of re-entrant production lines are governed by hyperbolic partial differential equations(PDEs)based on the law of mass conservation.展开更多
Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the...Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.展开更多
At present, multi-se nsor fusion is widely used in object recognition and classification, since this technique can efficiently improve the accuracy and the ability of fault toleranc e. This paper describes a multi-se...At present, multi-se nsor fusion is widely used in object recognition and classification, since this technique can efficiently improve the accuracy and the ability of fault toleranc e. This paper describes a multi-sensor fusion system, which is model-based and used for rotating mechanical failure diagnosis. In the data fusion process, the fuzzy neural network is selected and used for the data fusion at report level. By comparing the experimental results of fault diagnoses based on fusion data wi th that on original separate data,it is shown that the former is more accurate than the latter.展开更多
This book is greatly appreciated for its collection of various innovative activities which could be applied in different levels of technology-savvy classrooms.It is regarded as guidance to show paths for language educ...This book is greatly appreciated for its collection of various innovative activities which could be applied in different levels of technology-savvy classrooms.It is regarded as guidance to show paths for language educators to teach in digital age,although most of the teachers today are digital immigrants who "have become fascinated by and adopted many,or most aspects of the new technology are,and always will be compared to them"(Prensky,2001).They have to attempt to equip themselves with the knowledge of new media,which aims to provide the current students with their needs to become fully literate in this digital age.However,when the Internet began to arrive in schools,it was embraced by educators already seasoned in the challenges of change.展开更多
To deal with a lack of semantic interoperability of traditional knowledge retrieval approaches, a semantic-based networked manufacturing （NM） knowledge retrieval architecture is proposed, which offers a series of to...To deal with a lack of semantic interoperability of traditional knowledge retrieval approaches, a semantic-based networked manufacturing （NM） knowledge retrieval architecture is proposed, which offers a series of tools for supporting the sharing of knowledge and promoting NM collaboration. A 5-tuple based semantic information retrieval model is proposed, which includes the interoperation on the semantic layer, and a test process is given for this model. The recall ratio and the precision ratio of manufacturing knowledge retrieval are proved to be greatly improved by evaluation. Thus, a practical and reliable approach based on the semantic web is provided for solving the correlated concrete problems in regional networked manufacturing.展开更多
The random delays in a networked control system (NCS) degrade control performance and can even destabilize the control system.To deal with this problem,the time-stamped predictive functional control (PFC) algorithm is...The random delays in a networked control system (NCS) degrade control performance and can even destabilize the control system.To deal with this problem,the time-stamped predictive functional control (PFC) algorithm is proposed,which generalizes the standard PFC algorithm to networked control systems with random delays.The algorithm uses the time-stamp method to estimate the control delay,predicts the future outputs based on a discrete time delay state space model,and drives the control law that applies to an NCS from the idea of a PFC algorithm.A networked control system was constructed based on TrueTime simulator,with which the time-stamped PFC algorithm was compared with the standard PFC algorithm.The response curves show that the proposed algorithm has better control performance.展开更多
For the past decades,networked control systems(NCSs),as an interdisciplinary subject,have been one of the main research highlights and many fruitful results from different aspects have been achieved.With these growing...For the past decades,networked control systems(NCSs),as an interdisciplinary subject,have been one of the main research highlights and many fruitful results from different aspects have been achieved.With these growing research trends,it is significant to consolidate the latest knowledge and information to keep up with the research needs.In this paper,the results of different aspects of NCSs,such as quantization,estimation,fault detection and networked predictive control,are summarized.In addition,with the development of cloud technique,cloud control systems are proposed for the further development of NCSs.展开更多
This paper presents an Ethernet based hybrid method for predicting random time-delay in the networked control system.First,db3 wavelet is used to decompose and reconstruct time-delay sequence,and the approximation com...This paper presents an Ethernet based hybrid method for predicting random time-delay in the networked control system.First,db3 wavelet is used to decompose and reconstruct time-delay sequence,and the approximation component and detail components of time-delay sequences are fgured out.Next,one step prediction of time-delay is obtained through echo state network(ESN)model and auto-regressive integrated moving average model(ARIMA)according to the diferent characteristics of approximate component and detail components.Then,the fnal predictive value of time-delay is obtained by summation.Meanwhile,the parameters of echo state network is optimized by genetic algorithm.The simulation results indicate that higher accuracy can be achieved through this prediction method.展开更多
Abstract--This paper provides a survey on modeling and theories of networked control systems （NCS）. In the first part, modeling of the different types of imperfections that affect NCS is discussed. These imperfectio...Abstract--This paper provides a survey on modeling and theories of networked control systems （NCS）. In the first part, modeling of the different types of imperfections that affect NCS is discussed. These imperfections are quantization errors, packet dropouts, variable sampling/transmission intervals, vari- able transmission delays, and communication constraints. Then follows in the second part a presentation of several theories that have been applied for controlling networked systems. These theories include： input delay system approach, Markovian system approach, switched system approach, stochastic system approach, impulsive system approach, and predictive control approach. In the last part, some advanced issues in NCS including decentral- ized and distributed NCS, cloud control system, and co-design of NCS are reviewed. Index Terms--Decentralized networked control systems （NCS）, distributed networked control systems, network constraints, net- worked control system, quantization, time delays.展开更多
Networked control system is new hot-point in control engineering. A new delayed model for networked control systems is presented, based on which an LQR controller is designed. A method of delays estimation online is a...Networked control system is new hot-point in control engineering. A new delayed model for networked control systems is presented, based on which an LQR controller is designed. A method of delays estimation online is also given. For the difficulty on implementation of LQR in NCSs with time-variant delays, the Mamdani intelligent logic with LQR controller is addressed. The stability of the networked control system is also given. Simulation results prove that the novel controller can make the system stable and robustly preserve the performance in terms of time-variant delays.展开更多
The guaranteed cost control problem for networked control systems (NCSs) is addressed under communication constraints and varying sampling rate. First of all, a simple information-scheduling scheme is presented to des...The guaranteed cost control problem for networked control systems (NCSs) is addressed under communication constraints and varying sampling rate. First of all, a simple information-scheduling scheme is presented to describe the scheduling approach of system signals in NCSs. Then, based on such a scheme and given sampling method, the design procedure in dynamic output feedback manner is also derived which renders the closed loop system to be asymptotically stable and guarantees an upper bound of the LQ performance cost function.展开更多
Wireless Networked Control Systems (WNCS) are used to implement a control mechanism over a wireless network that is capable of carrying real-time traffic. This field has drawn enormous attention from current researche...Wireless Networked Control Systems (WNCS) are used to implement a control mechanism over a wireless network that is capable of carrying real-time traffic. This field has drawn enormous attention from current researchers because of its flexibility and robustness. However, designing efficient WNCS over Mobile Ad Hoc Networks (MANET) is still a challenging topic because of its less-predictable aspects, such as inconsistent delay, packet drop probability, and dynamic topology. This paper presents design guidelines for WNCS over MANET using the Network Simulator version 2, NS2 software. It investigates the impact of packet delay and packet drop under the AODV and DSR routing protocols. The simulation results have been compared to MATLAB results for validation. Keywords Adhoc On-Demand Distance Vector (AODV) routing - Dynamic Source routing (DSR) - Mobile Adhoc Networks (MANET) - Wireless Networked Control Systems (WNCS) Mohammad Shahidul Hasan received his BSc and first MSc in Computer Science from the University of Dhaka, Bangladesh. He obtained his 2nd MSc in Computer & Network Engineering from Sheffield Hallam University, Sheffield, UK. Currently he is pursuing his PhD under the Faculty of Computing, Engineering and Technology, Staffordshire University, Stafford, UK in Networked Control Systems over MANET.Chris Harding received his BSc in Computing Science and Masters by Research from Staffordshire University, UK. Currently he is pursuing his PhD in Wireless Networked Control Systems, specifically looking at NCS over MANETs, with research interests in this area concentrating on the network routing and effect of routing protocols on the NCS system.Hongnian Yu is Professor of Computer Science at Staffordshire University. He was a lecturer in Control and Systems Engineering at Yanshan University, China in 1985–1990, did his PhD in Robotics at King’s College London (1990–1994), was a research fellow in Manufacturing Systems at Sussex University (1994–1996), a lecturer in Artificial Intelligence at Liver-pool John Moore’s University (1996–1999), a lecturer in Control and Systems Engineering at the University of Exeter (1999–2002), and a Senior Lecturer in Computing at the University of Bradford (2002–2004). He now leads the Mobile Computing and Distributed Systems Research Group at Staffordshire University. He was a founding member of the Modeling Optimisation Scheduling and Intelligent Control research group at the University of Bradford. He has extensive research experience in neural networks, mobile computing, modeling, control of robot manipulators, and modeling, scheduling, planning, and simulations of large discrete event dynamic systems with applications to manufacturing systems, supply chains, transportation networks, and computer networks. He has published over 100 research papers focusing on the following: neural networks, computer networks, adaptive and robust control of robot manipulators, analysis and control of hybrid machines, control of timed delay systems, predictive control, manufacturing system modeling and scheduling, planning, and supply chains. He has held several research grants from EPSRC, the Royal Society, and the EU, as well as from industry. He was awarded the F.C. William Premium for his paper on adaptive and robust control of robot manipulators by the IEE Council in 1997. Professor Yu is an EPSRC college member, a member of IEEE, and a committee member of several conferences and journal editorial boards.Alison Griffiths has been a Senior Lecturer in Telecommunications at Staffordshire University since 2003. She was a lecturer in Computing at Staffordshire University in 2002–2003. She was a Research Associate on an EPSRC funded project whilst doing her PhD on the convergence of Mobile Computing and Telecommunications at Staffordshire University (1999–2003). The investigation consisted of the communication of different types of media (voice, video conferencing, web browsing, and downloading) over a common network, using a mobile device. Problems considered were the complications that occurred when a user moves, and consequently changes their end-point in the network during communication, with respect to the type of service the user is provided with (delays and losses). She obtained both her MEng and 1st Class BEng (Hons) from Staffordshire University in 1999 and 1998 respectively. She is now part of the Mobile Computing and Distributed Systems Research Group at Staffordshire University. She has published 8 research papers focusing on quality of service and access between cellular and IP packet switched networks. Future directions include mobile agents and control of mobile wireless ad-hoc networks. Her current research interests have extended to Wireless Networked Control Systems, specifically looking at NCS over MANETs, with research interests in this area concentrating on the network routing and effect of routing protocols on the NCS system.展开更多
基金supported in part by the National Natural Science Foundation of China(62173255,62188101)Shenzhen Key Laboratory of Control Theory and Intelligent Systems(ZDSYS20220330161800001)
文摘Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectively deal with nonlinearities,constraints,and noises in the system,optimize the performance metric,and present an upper bound on the stable output of the system.
基金supported in part by Shanghai Rising-Star Program,China under grant 22QA1409400in part by National Natural Science Foundation of China under grant 62473287 and 62088101in part by Shanghai Municipal Science and Technology Major Project under grant 2021SHZDZX0100.
文摘This paper investigates the problem of optimal secure control for networked control systems under hybrid attacks.A control strategy based on the Stackelberg game framework is proposed,which differs from conventional methods by considering both denial-of-service(DoS)and false data injection(FDI)attacks simultaneously.Additionally,the stability conditions for the system under these hybrid attacks are established.It is technically challenging to design the control strategy by predicting attacker actions based on Stcakelberg game to ensure the system stability under hybrid attacks.Another technical difficulty lies in establishing the conditions for mean-square asymptotic stability due to the complexity of the attack scenarios Finally,simulations on an unstable batch reactor system under hybrid attacks demonstrate the effectiveness of the proposed strategy.
基金funded in part by Grant No.RG-15-135-43 from the Deanship of Scientific Research(DSR)at King Abdulaziz University in Saudi Arabia.
文摘The proliferation of distributed and renewable energy resources introduces additional operational challenges to power distribution systems.Transactive energy management,which allows networked neighborhood communities and houses to trade energy,is expected to be developed as an effective method for accommodating additional uncertainties and security mandates pertaining to distributed energy resources.This paper proposes and analyzes a two-layer transactive energy market in which houses in networked neighborhood community microgrids will trade energy in respective market layers.This paper studies the blockchain applications to satisfy socioeconomic and technological concerns of secure transactive energy management in a two-level power distribution system.The numerical results for practical networked microgrids located at IllinoisTech−Bronzeville in Chicago illustrate the validity of the proposed blockchain-based transactive energy management for devising a distributed,scalable,efficient,and cybersecured power grid operation.The conclusion of the paper summarizes the prospects for blockchain applications to transactive energy management in power distribution systems.
基金Supported by Key Research and Development Program of Shaanxi Province,China,No.2024SF-YBXM-078.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.
基金supported by grants from the National Natural Science Foundation of China(82004252)the Project of Administration of Traditional Chinese Medicine of Guangdong Province(202405112017596500)the Basic and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau(202102020533).
文摘Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.
基金supported in part by the Australian Research Council Discovery Project(DP190101557)
文摘To handle input and output time delays that commonly exist in many networked control systems(NCSs), a new robust continuous sliding mode control(CSMC) scheme is proposed for the output tracking in uncertain single input-single-output(SISO) networked control systems. This scheme consists of three consecutive steps. First, although the network-induced delay in those systems can be effectively handled by using Pade approximation(PA), the unmatched disturbance cames out as another difficulty in the control design. Second, to actively estimate this unmatched disturbance, a generalized proportional integral observer(GPIO) technique is utilized based on only one measured state. Third, by constructing a new sliding manifold with the aid of the estimated unmatched disturbance and states, a GPIO-based CSMC is synthesized, which is employed to cope with not only matched and unmatched disturbances, but also networkinduced delays. The stability of the entire closed-loop system under the proposed GPIO-based CSMC is detailedly analyzed.The promising tracking efficiency and feasibility of the proposed control methodology are verified through simulations and experiments on Quanser's servo module for motion control under various test conditions.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
文摘Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the production line,the manufacturing layer and the workshop layer.The dynamics of re-entrant production lines are governed by hyperbolic partial differential equations(PDEs)based on the law of mass conservation.
基金supported by the Liaoning Revitalization Talents Program(XLYC2203148)
文摘Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.
文摘At present, multi-se nsor fusion is widely used in object recognition and classification, since this technique can efficiently improve the accuracy and the ability of fault toleranc e. This paper describes a multi-sensor fusion system, which is model-based and used for rotating mechanical failure diagnosis. In the data fusion process, the fuzzy neural network is selected and used for the data fusion at report level. By comparing the experimental results of fault diagnoses based on fusion data wi th that on original separate data,it is shown that the former is more accurate than the latter.
文摘This book is greatly appreciated for its collection of various innovative activities which could be applied in different levels of technology-savvy classrooms.It is regarded as guidance to show paths for language educators to teach in digital age,although most of the teachers today are digital immigrants who "have become fascinated by and adopted many,or most aspects of the new technology are,and always will be compared to them"(Prensky,2001).They have to attempt to equip themselves with the knowledge of new media,which aims to provide the current students with their needs to become fully literate in this digital age.However,when the Internet began to arrive in schools,it was embraced by educators already seasoned in the challenges of change.
基金The National High Technology Research and Devel-opment Program of China (863Program) (No2003AA1Z2560,2002AA414060)the Key Science and Technology Program of Shaanxi Province (No2006K04-G10)
文摘To deal with a lack of semantic interoperability of traditional knowledge retrieval approaches, a semantic-based networked manufacturing （NM） knowledge retrieval architecture is proposed, which offers a series of tools for supporting the sharing of knowledge and promoting NM collaboration. A 5-tuple based semantic information retrieval model is proposed, which includes the interoperation on the semantic layer, and a test process is given for this model. The recall ratio and the precision ratio of manufacturing knowledge retrieval are proved to be greatly improved by evaluation. Thus, a practical and reliable approach based on the semantic web is provided for solving the correlated concrete problems in regional networked manufacturing.
文摘The random delays in a networked control system (NCS) degrade control performance and can even destabilize the control system.To deal with this problem,the time-stamped predictive functional control (PFC) algorithm is proposed,which generalizes the standard PFC algorithm to networked control systems with random delays.The algorithm uses the time-stamp method to estimate the control delay,predicts the future outputs based on a discrete time delay state space model,and drives the control law that applies to an NCS from the idea of a PFC algorithm.A networked control system was constructed based on TrueTime simulator,with which the time-stamped PFC algorithm was compared with the standard PFC algorithm.The response curves show that the proposed algorithm has better control performance.
基金supported by National Basic Research Program of China(973 Program)(No.2012CB720000)National Natural Science Foundation of China(Nos.61225015 and 60974011)+3 种基金Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.61321002)Beijing Municipal Natural Science Foundation(Nos.4102053 and 4101001)Beijing Natural Science Foundation(Nos.4132042)Beijing Higher Education Young Elite Teacher Project(No.YETP1212)
文摘For the past decades,networked control systems(NCSs),as an interdisciplinary subject,have been one of the main research highlights and many fruitful results from different aspects have been achieved.With these growing research trends,it is significant to consolidate the latest knowledge and information to keep up with the research needs.In this paper,the results of different aspects of NCSs,such as quantization,estimation,fault detection and networked predictive control,are summarized.In addition,with the development of cloud technique,cloud control systems are proposed for the further development of NCSs.
基金supported by National Natural Science Foundation of China(No.61034005)
文摘This paper presents an Ethernet based hybrid method for predicting random time-delay in the networked control system.First,db3 wavelet is used to decompose and reconstruct time-delay sequence,and the approximation component and detail components of time-delay sequences are fgured out.Next,one step prediction of time-delay is obtained through echo state network(ESN)model and auto-regressive integrated moving average model(ARIMA)according to the diferent characteristics of approximate component and detail components.Then,the fnal predictive value of time-delay is obtained by summation.Meanwhile,the parameters of echo state network is optimized by genetic algorithm.The simulation results indicate that higher accuracy can be achieved through this prediction method.
基金supported by the Deanship of Scientific Research(DSR) at KFUPM through Research Project(IN141048)
文摘Abstract--This paper provides a survey on modeling and theories of networked control systems （NCS）. In the first part, modeling of the different types of imperfections that affect NCS is discussed. These imperfections are quantization errors, packet dropouts, variable sampling/transmission intervals, vari- able transmission delays, and communication constraints. Then follows in the second part a presentation of several theories that have been applied for controlling networked systems. These theories include： input delay system approach, Markovian system approach, switched system approach, stochastic system approach, impulsive system approach, and predictive control approach. In the last part, some advanced issues in NCS including decentral- ized and distributed NCS, cloud control system, and co-design of NCS are reviewed. Index Terms--Decentralized networked control systems （NCS）, distributed networked control systems, network constraints, net- worked control system, quantization, time delays.
文摘Networked control system is new hot-point in control engineering. A new delayed model for networked control systems is presented, based on which an LQR controller is designed. A method of delays estimation online is also given. For the difficulty on implementation of LQR in NCSs with time-variant delays, the Mamdani intelligent logic with LQR controller is addressed. The stability of the networked control system is also given. Simulation results prove that the novel controller can make the system stable and robustly preserve the performance in terms of time-variant delays.
基金This work was supported by the National Natural Science Foundation of China (No.60274014)Specialized+1 种基金Research Fund for the Doctoral Program of Higher Education (No. 20020487006)China Education Ministry' s Key Laboratory Foundation for Intelligent Ma
文摘The guaranteed cost control problem for networked control systems (NCSs) is addressed under communication constraints and varying sampling rate. First of all, a simple information-scheduling scheme is presented to describe the scheduling approach of system signals in NCSs. Then, based on such a scheme and given sampling method, the design procedure in dynamic output feedback manner is also derived which renders the closed loop system to be asymptotically stable and guarantees an upper bound of the LQ performance cost function.
文摘Wireless Networked Control Systems (WNCS) are used to implement a control mechanism over a wireless network that is capable of carrying real-time traffic. This field has drawn enormous attention from current researchers because of its flexibility and robustness. However, designing efficient WNCS over Mobile Ad Hoc Networks (MANET) is still a challenging topic because of its less-predictable aspects, such as inconsistent delay, packet drop probability, and dynamic topology. This paper presents design guidelines for WNCS over MANET using the Network Simulator version 2, NS2 software. It investigates the impact of packet delay and packet drop under the AODV and DSR routing protocols. The simulation results have been compared to MATLAB results for validation. Keywords Adhoc On-Demand Distance Vector (AODV) routing - Dynamic Source routing (DSR) - Mobile Adhoc Networks (MANET) - Wireless Networked Control Systems (WNCS) Mohammad Shahidul Hasan received his BSc and first MSc in Computer Science from the University of Dhaka, Bangladesh. He obtained his 2nd MSc in Computer & Network Engineering from Sheffield Hallam University, Sheffield, UK. Currently he is pursuing his PhD under the Faculty of Computing, Engineering and Technology, Staffordshire University, Stafford, UK in Networked Control Systems over MANET.Chris Harding received his BSc in Computing Science and Masters by Research from Staffordshire University, UK. Currently he is pursuing his PhD in Wireless Networked Control Systems, specifically looking at NCS over MANETs, with research interests in this area concentrating on the network routing and effect of routing protocols on the NCS system.Hongnian Yu is Professor of Computer Science at Staffordshire University. He was a lecturer in Control and Systems Engineering at Yanshan University, China in 1985–1990, did his PhD in Robotics at King’s College London (1990–1994), was a research fellow in Manufacturing Systems at Sussex University (1994–1996), a lecturer in Artificial Intelligence at Liver-pool John Moore’s University (1996–1999), a lecturer in Control and Systems Engineering at the University of Exeter (1999–2002), and a Senior Lecturer in Computing at the University of Bradford (2002–2004). He now leads the Mobile Computing and Distributed Systems Research Group at Staffordshire University. He was a founding member of the Modeling Optimisation Scheduling and Intelligent Control research group at the University of Bradford. He has extensive research experience in neural networks, mobile computing, modeling, control of robot manipulators, and modeling, scheduling, planning, and simulations of large discrete event dynamic systems with applications to manufacturing systems, supply chains, transportation networks, and computer networks. He has published over 100 research papers focusing on the following: neural networks, computer networks, adaptive and robust control of robot manipulators, analysis and control of hybrid machines, control of timed delay systems, predictive control, manufacturing system modeling and scheduling, planning, and supply chains. He has held several research grants from EPSRC, the Royal Society, and the EU, as well as from industry. He was awarded the F.C. William Premium for his paper on adaptive and robust control of robot manipulators by the IEE Council in 1997. Professor Yu is an EPSRC college member, a member of IEEE, and a committee member of several conferences and journal editorial boards.Alison Griffiths has been a Senior Lecturer in Telecommunications at Staffordshire University since 2003. She was a lecturer in Computing at Staffordshire University in 2002–2003. She was a Research Associate on an EPSRC funded project whilst doing her PhD on the convergence of Mobile Computing and Telecommunications at Staffordshire University (1999–2003). The investigation consisted of the communication of different types of media (voice, video conferencing, web browsing, and downloading) over a common network, using a mobile device. Problems considered were the complications that occurred when a user moves, and consequently changes their end-point in the network during communication, with respect to the type of service the user is provided with (delays and losses). She obtained both her MEng and 1st Class BEng (Hons) from Staffordshire University in 1999 and 1998 respectively. She is now part of the Mobile Computing and Distributed Systems Research Group at Staffordshire University. She has published 8 research papers focusing on quality of service and access between cellular and IP packet switched networks. Future directions include mobile agents and control of mobile wireless ad-hoc networks. Her current research interests have extended to Wireless Networked Control Systems, specifically looking at NCS over MANETs, with research interests in this area concentrating on the network routing and effect of routing protocols on the NCS system.
