As an indispensable component of the emerging 6G networks,Space-Air-Ground Inte-grated Networks(SAGINs)are envisioned to provide ubiquitous network connectivity and services by integrating satellite networks,aerial ne...As an indispensable component of the emerging 6G networks,Space-Air-Ground Inte-grated Networks(SAGINs)are envisioned to provide ubiquitous network connectivity and services by integrating satellite networks,aerial networks,and terrestrial networks.In 6G SAGINs,a wide variety of network services with the features of diverse requirements,complex mobility,and multi-dimensional resources will pose great challenges to service provisioning,which urges the develop-ment of service-oriented SAGINs.In this paper,we conduct a comprehensive review of 6G SAGINs from a new perspective of service-oriented network.First,we present the requirements of service-oriented networks,and then propose a service-oriented SAGINs management architec-ture.Two categories of critical technologies are presented and discussed,i.e.,heterogeneous resource orchestration technologies and the cloud-edge synergy technologies,which facilitate the interoperability of different network segments and cooperatively orchestrate heterogeneous resources across different domains,according to the service features and requirements.In addition,the potential future research directions are also presented and discussed.展开更多
文摘基于网络药理和分子对接技术研究樱桃李多酚(Prunus cerasifera Ehrhart polyphenols,PEP)抗2型糖尿病(diabetes mellitus type 2,T2DM)的潜在作用机制。通过查阅文献搜集樱桃李多酚的活性成分;利用PubChem、Sea和SwissTargetPrediction数据库获取樱桃李多酚活性成分的靶点蛋白,GeneCards和OMIM数据库检索T2DM的疾病靶点。利用String数据库构建蛋白-蛋白互作(protein-protein interaction,PPI)网络并进行拓扑学分析。利用DAVID数据库进行基因本体(Gene Ontology,GO)和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析。利用Cytoscape 3.9.1软件构建“活性成分-核心靶点-通路”网络。使用AutoDock Vina 1.1.2和Py-Mol 2.5.4软件计算结合能并进行分子对接可视化。结果表明,筛选得到樱桃李多酚的24种活性成分及对应的HRAS、VEGFA等13个核心靶点;GO分析其主要涉及的生物过程包括丝裂原活化蛋白激酶(mitogen-activated pro-tein kinase,MAPK)级联的正向调节、蛋白质磷酸化的正调节和基因表达的负调控等;KEGG富集分析主要涉及MAPK信号通路、糖尿病并发症中的高级糖基化终末产物-受体(advanced glycation end products-receptor for advanced glycation end products,AGE-RAGE)信号通路和缺氧诱导因子1(hypoxia-inducible factor 1,HIF-1)信号通路等。综上,樱桃李多酚中的多种活性成分可通过多靶点、多通路发挥抗T2DM的作用。
基金supported by the National Key Research and Development Program of China(No.2020YFB1807700).
文摘As an indispensable component of the emerging 6G networks,Space-Air-Ground Inte-grated Networks(SAGINs)are envisioned to provide ubiquitous network connectivity and services by integrating satellite networks,aerial networks,and terrestrial networks.In 6G SAGINs,a wide variety of network services with the features of diverse requirements,complex mobility,and multi-dimensional resources will pose great challenges to service provisioning,which urges the develop-ment of service-oriented SAGINs.In this paper,we conduct a comprehensive review of 6G SAGINs from a new perspective of service-oriented network.First,we present the requirements of service-oriented networks,and then propose a service-oriented SAGINs management architec-ture.Two categories of critical technologies are presented and discussed,i.e.,heterogeneous resource orchestration technologies and the cloud-edge synergy technologies,which facilitate the interoperability of different network segments and cooperatively orchestrate heterogeneous resources across different domains,according to the service features and requirements.In addition,the potential future research directions are also presented and discussed.
