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Research on Digital and Analog Electronic Experiment Teaching Course Management based on UltraLab Network Experiment Platform
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作者 FAN Yiqiang ZHANG Jing +2 位作者 YU Haoran HE Guannan YUAN Hongfang 《International Journal of Plant Engineering and Management》 2018年第4期206-215,共10页
Digital circuit and analog circuit courses are basic courses for students of science and engineering universities. Among them,the practical courses are of great significance for students to master the knowledge of ele... Digital circuit and analog circuit courses are basic courses for students of science and engineering universities. Among them,the practical courses are of great significance for students to master the knowledge of electronics. In order to make teachers teaching more efficiently and students studying more quickly,how to update the experimental course in teaching reform is the key point. This paper analyzing the present situation of teaching in the digital circuit and analog circuit courses,the teaching questions in universities. On the basis of it,the innovation measures of experimental teaching methods and contents are discussed. Our school tries to introduce the UltraLab network experiment platform,reform and optimize the teaching methods of related courses.And it’ s accelerating the construction and development of emerging engineering education’ s process,reducing effectively the teacher’s time for managing in equipment,improving the students’ ability to use instruments. 展开更多
关键词 Index terms-teaching reform in digital and analog circuit UltraLab network experimental platform network management for equipment Emerging engineering education
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Hydrological Extremes in Small Basins-The 12th Biennial Conference of the Mediterranean Network of Experimental and Representative Basins (ERB)
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作者 Wojciech Chelmicki Janusz Siwek 《Episodes》 2009年第1期56-57,共2页
The Mediterranean Network of Experimental and Representative Basins(ERB)is an open association of hydrologists from twenty European countries carrying out their research in well-instrumented,small drainage basins.The ... The Mediterranean Network of Experimental and Representative Basins(ERB)is an open association of hydrologists from twenty European countries carrying out their research in well-instrumented,small drainage basins.The ERB was recommended by the European Council and established in 1986.The main objectives of the network are:-to establish and maintain relationships among member countries and research teams by means of information exchange,mobility,and regular conferences;-to initiate and enable co-operation among members and other organizations;-to maintain databases of small-scale research and experimental basins. 展开更多
关键词 experimental representative basins erb Mediterranean network experimental Representative Basins ERB hydrologists establish maintain relationships research well instrumented hydrological extremes small basins
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Experimental Study of the Voltage Quality of the Low Voltage Distribution Network: Application to the City of Bobo-Dioulasso 被引量:1
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作者 Abdoulaye Zongo Frédéric Ouattara 《Open Journal of Applied Sciences》 CAS 2022年第7期1262-1270,共9页
The electrical energy produced must be consumed at the same time, hence the need to achieve a balance between supply and demand. Therefore, the production, transport, and distribution systems together constitute an el... The electrical energy produced must be consumed at the same time, hence the need to achieve a balance between supply and demand. Therefore, the production, transport, and distribution systems together constitute an electricity network. The distribution networks are designed to deliver energy to consumers. Unacceptable voltage drops are observed in the distribution networks of developing countries such as Burkina Faso. A study was carried out on the distribution network of the city of Bobo-Dioulasso in Burkina Faso. It allowed for experimentation with the “Megger MPQ1000” network analyzer to evaluate the quality of the voltage supplied to households. To this end, tests were carried out in a public distribution station and at a few subscribers in the Sarfalao district of the city of Bobo-Dioulasso. These tests were used to assess the percentage of voltage drops. These values, which are higher than 8% of the nominal voltage, are not regulatory. The load curves of the consumers in the district were also drawn. Indeed, the period of the high load is between 19:00 and 23:00 Local Time (LT), while the period of the medium and low load is between 00:00 and 18:00 LT. 展开更多
关键词 experimentAL Voltage Drop MV/LV networks network Analyzer
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Design and Implementation of Online Experimental Platform for Computer Networks Course
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作者 WANG Ben ZHANG Tao 《计算机教育》 2012年第10期45-47,共3页
Practice training is very important for students learning Computer networks.But building a real laboratory is constrained and expensive.In this paper,we present an online experimental platform for computer networks co... Practice training is very important for students learning Computer networks.But building a real laboratory is constrained and expensive.In this paper,we present an online experimental platform for computer networks course based on Dynamips simulator.Instructors and students can access the platform by IE Browser to manage and take router experiments.On the basis of deployment and testing,the platform is effective and flexible. 展开更多
关键词 Online experimental Platform Computer networks Course DYNAMIPS
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An Exploratory Study of Experimental Tools for Wireless Sensor Networks
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作者 A.K. Dwivedi O.P. Vyas 《Wireless Sensor Network》 2011年第7期215-240,共26页
The objective of this contribution is to present expositive review content on currently available experimental tools/services/concepts used for most emerging field Wireless Sensor Network that has capability to change... The objective of this contribution is to present expositive review content on currently available experimental tools/services/concepts used for most emerging field Wireless Sensor Network that has capability to change many of the Information Communication aspects in the upcoming era. Currently due to high cost of large number of sensor nodes most researches in wireless sensor networks area is performed by using these experimental tools in various universities, institutes, and research centers before implementing real one. Also the statistics gathered from these experimental tools can be realistic and convenient. These experimental tools provide the better option for studying the behavior of WSNs before and after implementing the physical one. In this contribution 63 simulators/simulation frameworks, 14 emulators, 19 data visualization tools, 46 testbeds, 26 debugging tools/services/concepts, 10 code-updation/reprogramming tools and 8 network monitors has been presented that are used worldwide for WSN researches. 展开更多
关键词 experimentAL TOOLS Simulation EMULATION TESTBED Data visualization DEBUGGER network Monitor Code-updater Wireless Sensor network
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川滇地区人工智能地震预测模型应用
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作者 孟令媛 胡峰 +7 位作者 臧阳 司旭 闫伟 田雷 赵小艳 张致伟 韩颜颜 王月 《地震研究》 北大核心 2026年第1期43-50,共8页
针对中国地震科学实验场的科学目标和主要科学问题,基于川滇地区地震目录和地球物理观测数据,在对川滇地区进行区域划分并建立图神经网络的基础上,构建了川滇地区地震预测模型。该模型综合考虑约3万条地震目录数据、基于地震目录的3种... 针对中国地震科学实验场的科学目标和主要科学问题,基于川滇地区地震目录和地球物理观测数据,在对川滇地区进行区域划分并建立图神经网络的基础上,构建了川滇地区地震预测模型。该模型综合考虑约3万条地震目录数据、基于地震目录的3种地震活动性参数,以及116台项地球物理观测数据,通过将传统经验预测指标方法与人工智能技术结合,给出了适用于川滇地区的多源异构数据图神经网络地震预测模型,实现了川滇地区不同数据源下短期与中期地震预测功能。模型应用结果显示,在CD2、CD8和CD10区域月尺度预测效果较好,年尺度无震预测有一定对应效果。 展开更多
关键词 中国地震科学实验场 多源异构数据 图神经网络 地震预测模型 川滇地区
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AI Graf Compounder在橡胶配方开发模拟中的应用研究
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作者 章羽(编译) 《橡塑技术与装备》 2026年第1期76-81,共6页
本文探讨了AI Graf Compounder软件在橡胶配方开发中的应用。该系统基于前馈神经网络,能够根据成分预测材料性能,显著减少物理测试需求并加快研发进程。研究通过多个案例验证了其在EPDM、天然橡胶等配方中的预测准确性,强调高质量结构... 本文探讨了AI Graf Compounder软件在橡胶配方开发中的应用。该系统基于前馈神经网络,能够根据成分预测材料性能,显著减少物理测试需求并加快研发进程。研究通过多个案例验证了其在EPDM、天然橡胶等配方中的预测准确性,强调高质量结构化数据(尤其是实验设计数据)对模拟结果的重要性。人工智能与结构化实验设计的结合,为橡胶行业提供了更高效、数据驱动的开发路径。 展开更多
关键词 人工智能 橡胶配方开发 神经网络 实验设计 数据驱动模型
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China Unicom's Experience in Network Evolution towards NGN
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作者 Li Xiaoming (Department of Data & Fixed Communications,China Unicom,Beijing 100032,China) 《ZTE Communications》 2004年第1期48-49,共2页
The article introduces China Unicom's valuable experience obtained in the construction and operation of its IP-based data and fixed services network. In the construction of the network,China Unicom aimed at the qu... The article introduces China Unicom's valuable experience obtained in the construction and operation of its IP-based data and fixed services network. In the construction of the network,China Unicom aimed at the quick deployment of telecom-level integrated services by building up multi-level metropolitan area networks and access networks;in the operation of the network,China Unicorn made great efforts with equipment manufactures, software developers and system integration providers and achieved stable and improved network performance. 展开更多
关键词 China Unicom’s Experience in network Evolution towards NGN IP POP
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Reflections on the Experience of Network Virtual Space FromPhenomenology of Technics
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作者 MA Wen-wu 《Journal of Philosophy Study》 2019年第10期610-615,共6页
People create network virtual space that is completely different from the real space through network information technologies.The characteristics of network virtual space are that the subject can obtain a similar real... People create network virtual space that is completely different from the real space through network information technologies.The characteristics of network virtual space are that the subject can obtain a similar real space experience.From the perspective of phenomenology of technics,in order to analyze the virtual space of the network,it is necessary to clear the phenomenological concepts,such as space,space experience,and virtual space experience,so as to know the type of network virtual space experience,explore the essential characteristics,and find solutions to the ethical conflicts in the virtual space experience of the network. 展开更多
关键词 the experience of network virtual space phenomenology of technics Don Ihde ethical conflicts and countermeasures
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Evaluation of a Heterogeneous Sensor Network Architecture for Highly Mobile Users
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作者 Chen Zhong Jens Eliasson +1 位作者 Rumen Kyusakov Jerker Delsing 《Communications and Network》 2011年第2期57-64,共8页
This paper presents experimental results of a heterogeneous sensor network architecture, which is a combination of a wireless sensor network and a personal area network. The proposed architecture uses the IEEE 802.15.... This paper presents experimental results of a heterogeneous sensor network architecture, which is a combination of a wireless sensor network and a personal area network. The proposed architecture uses the IEEE 802.15.4 standard to transmit sensor data to a sensor node which in turn forwards the data using TCP/IP to a database on the Internet via a Bluetooth-equipped mobile phone and the mobile telephone access network. The performance of the entire communication chain is evaluated. First, a 3G network's performance is evaluated by measuring its round trip time for packet transmission. Second, the real-world end-to-end delay between a sensor node and a database server on the Internet is measured using two different experimental set-ups: single-hop transmission and two hops transmission. Finally, the proposed architecture's scalability is estimated in a Matlab simulation using the results of the experiments as a base. The results show that the proposed architecture is applicable for small-scale sensor networks used by highly mobile users. 展开更多
关键词 WSN PAN MOBILE Sensor network SCALABILITY experimentAL
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基于网络药理学及动物实验探讨粉防己碱治疗重症急性胰腺炎的分子机制 被引量:2
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作者 段丽芳 范建伟 +1 位作者 许小凡 张红 《中药新药与临床药理》 北大核心 2025年第4期576-583,共8页
目的基于网络药理学及动物实验探讨粉防己碱治疗重症急性胰腺炎(SAP)的分子机制。方法(1)采用Swiss Target Prediction、BATMAN-TCM数据库检索获得粉防己碱作用靶点,采用GeneCards、OMIM、DisGeNet、PharmGkb数据库检索获得SAP疾病靶点... 目的基于网络药理学及动物实验探讨粉防己碱治疗重症急性胰腺炎(SAP)的分子机制。方法(1)采用Swiss Target Prediction、BATMAN-TCM数据库检索获得粉防己碱作用靶点,采用GeneCards、OMIM、DisGeNet、PharmGkb数据库检索获得SAP疾病靶点,对二者取交集并绘制韦恩图,得到粉防己碱治疗SAP的潜在作用靶点(共同靶点)。通过String数据库构建潜在作用靶点蛋白互作(PPI)网络,筛选关键靶点。利用David、KOBAS数据库对潜在作用靶点进行GO功能及KEGG通路富集分析。(2)将昆明小鼠随机分为空白对照组、模型组、粉防己碱组,每组10只。模型组及粉防己碱组小鼠均给予腹腔注射20%L-精氨酸(3.5 g·kg^(-1)),共2次,每次间隔1 h,复制SAP小鼠模型。于末次注射L-精氨酸4 h后,粉防己碱组给予粉防己碱溶液(120 mg·kg^(-1))腹腔注射,每天2次,连续3 d。计算胰腺脏体比;采用全自动生化分析仪检测血清淀粉酶水平;HE染色法观察胰腺组织病理变化,并从组织水肿、炎症及坏死三个方面进行评分;免疫组化法观察胰腺组织IL-6、p-STAT3表达情况;Western Blot法检测胰腺组织IL-6、p-STAT3、STAT3蛋白表达水平。结果(1)共分析得到粉防己碱治疗SAP的潜在作用靶点24个,AKT1、ERBB2、SRC、MTOR、PIK3CA、CXCR4、JAK2等为关键靶点;GO功能分析的生物过程主要涉及蛋白质自身磷酸化、肽基-酪氨酸磷酸化、蛋白磷酸化、凋亡过程的负调控;KEGG通路主要涉及PI3K-Akt信号通路、JAK-STAT信号通路、TLR信号通路、Rap1信号通路、FoxO信号通路等。(2)与空白对照组比较,模型组小鼠胰腺结构明显破坏,出现大量腺泡细胞变性坏死,仅残存少量分散的腺泡细胞,间质高度水肿,伴大量炎性细胞浸润;胰腺组织水肿评分、炎症评分、坏死评分、总体评分、胰腺脏体比相对值及血清淀粉酶水平均显著升高(P<0.01);小鼠胰腺间质可见大量IL-6、p-STAT3阳性表达,IL-6、p-STAT3/STAT3蛋白表达水平均显著升高(P<0.01)。与模型组比较,粉防己碱组小鼠胰腺结构损伤程度明显减轻,腺泡细胞坏死范围明显缩小,间质水肿程度减轻,仅见少量炎症细胞浸润;胰腺组织水肿评分、炎症评分、坏死评分、总体评分、胰腺脏体比相对值及血清淀粉酶水平均显著降低(P<0.01);小鼠胰腺间质的IL-6、p-STAT3阳性表达明显减少,IL-6、p-STAT3/STAT3蛋白表达水平均显著降低(P<0.01)。结论粉防己碱防治SAP具有多靶点、多通路的作用特点,可能通过抑制IL-6/STAT3信号通路改善SAP小鼠胰腺组织的炎症反应。 展开更多
关键词 粉防己碱 重症急性胰腺炎 IL-6/STAT3信号通路 网络药理学 实验验证 胰腺组织 炎症反应 小鼠
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Thermo-mechanical coupling analysis of APSE using submodels and neural networks
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作者 Sangki Kwon Changsoo Lee +1 位作者 Seokwon Jeon Heui-Joo Choi 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2013年第1期32-43,共12页
The ,Aspoe Pillar Stability Experiment (APSE) is an in situ experiment for investigating the spalling mechanism under mechanical and thermal loading conditions in a crystalline rock. In this study, the thermo-mechan... The ,Aspoe Pillar Stability Experiment (APSE) is an in situ experiment for investigating the spalling mechanism under mechanical and thermal loading conditions in a crystalline rock. In this study, the thermo-mechanical behaviors in the APSE were investigated with three models: (1) a Full model with rough meshes for calculating the influence of tunnel excavation; (2) a Submodel with fine meshes for predicting the thermo-mechanical behavior in the pillar during the borehole drilling, heating, and cool- ing phases; and (3) a Thin model for modeling the effect of slot cutting for de-stressing around the pillar. In order to import the stresses calculated from the Full model to the Submodel and to define the complex thermal boundary conditions, artificial neural networks (NNs) were utilized. From this study, it was pos- sible to conclude that the stepwise approach with the application of NNs was useful for predicting the complex response of the pillar under severe thermo-mechanical loading conditions. 展开更多
关键词 Sspoe Pillar Stability experiment (APSE)Artificial neural network (NN)SubmodelThermo-mechanical couplingSpalling
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Getting the Balance Right in Intercultural Groups: A Dynamic Social Network Perspective
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作者 Bart Rienties Novie Johan 《Social Networking》 2014年第3期173-185,共13页
Problem: A common assumption is that students prefer to select their friends for group-work. The prime goal of this study was to understand the impact of two group selection methods on how students from diverse cultur... Problem: A common assumption is that students prefer to select their friends for group-work. The prime goal of this study was to understand the impact of two group selection methods on how students from diverse cultural backgrounds build learning and work relations. Method: Social Network Analysis in a pre-post test manner in a quasi-experimental design of 81 vs. 70 third-year students. Solution: In this study, we “disrupted” this group selection process after Day 1 by balancing students from different parts of the social network together. In one condition the students were “balanced” into groups by staff to encourage structural hole formation, and in the other condition students were allowed to self-select their group members to encourage network closure. Results: Students in the self-selected condition primarily selected their friends from a similar cultural background. In both conditions the learning networks after 11 weeks were primarily predicted by the group allocation and initial friendships. However, students in the balanced condition developed more cross-cultural learning links. These results indicate that teachers can actively intervene in the cross-cultural dynamics in- and outside the classroom. 展开更多
关键词 Social network Analysis CROSS-CULTURAL Learning QUASI-experimentAL Study Structural Hole vs network CLOSURE
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调周滋阴方治疗早发性卵巢功能不全的疗效、安全性及作用机制
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作者 唐培培 谈勇 +4 位作者 殷燕云 聂晓伟 黄菁宇 左文婷 李玉玲 《南方医科大学学报》 北大核心 2025年第5期929-941,共13页
目的基于网络药理学探讨调周滋阴方治疗早发性卵巢功能不全(POI)的作用机制,通过动物实验进行验证,并设计临床对照试验验证调周滋阴方对该病的临床疗效。方法利用TCMSP、PubChem、Swiss Target Prediction、Genecards、OMIM等数据库筛... 目的基于网络药理学探讨调周滋阴方治疗早发性卵巢功能不全(POI)的作用机制,通过动物实验进行验证,并设计临床对照试验验证调周滋阴方对该病的临床疗效。方法利用TCMSP、PubChem、Swiss Target Prediction、Genecards、OMIM等数据库筛选相应靶点,获取核心PPI,进行GO、KEGG富集分析,构建“疾病-通路-靶点-成分-药物”网络,采用AutoDock对核心活性成分和核心靶点进行分子对接验证。通过动物实验,采用Western blotting进一步验证网络药理学结果。设计临床对照试验,对照组予芬吗通治疗,试验组在此基础上加用调周滋阴方,通过观察两组内分泌指标(FSH、LH、E2、AMH)、窦卵泡数、Kupperman评分、不良反应发生率及妊娠率,验证调周滋阴方治疗该病的临床有效性。结果通过网络药理学方法,得到调周滋阴方治疗早发性卵巢功能不全的潜在靶点有163个;核心活性成分主要为山奈酚、β-谷甾醇、木犀草素、槲皮素,核心靶点主要为SRC、TP53、STAT3、PIK3CA、MAPK3等;GO功能富集主要包括细胞运动的正调控、蛋白质磷酸化等;KEGG富集通路主要包括癌症通路、PI3K-Akt信号通路等;分子对接结果显示核心活性成分与核心靶点间均有良好的结合能力。利用动物实验对关键通路进行验证,结果显示,与POI模型组大鼠比较,调周滋阴方可升高POI大鼠卵巢组织中p-PI3K和p-Akt蛋白表达(P<0.05),验证了网络药理学的部分预测结果。临床试验显示,两组E2较治疗前升高,FSH、LH较治疗前降低,Kupperman评分较治疗前降低(P<0.05),且试验组优于对照组(P<0.05);两组窦卵泡数较治疗前均升高(P<0.05),试验组AMH较治疗前升高(P<0.05),试验组与对照组间的差异无统计学意义(P>0.05);治疗结束4周后,试验组治疗效果优于同期对照组(P<0.05)。结论调周滋阴方具有多成分、多靶点、多途径的治疗特点,其中激活PI3K/Akt通路是其作用机制之一,从而改善POI患者卵巢储备功能,缓解临床症状,提高临床疗效,具有良好的临床应用前景。 展开更多
关键词 早发性卵巢功能不全 调周滋阴方 网络药理学 实验验证 临床观察
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基于生物信息学及实验验证探讨麦冬皂苷D治疗特发性肺纤维化的作用机制 被引量:1
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作者 李仲普 黄乐 +3 位作者 刘雨 胡学军 邓秀娟 管聘 《中药新药与临床药理》 北大核心 2025年第2期219-229,共11页
目的整合生物信息学、网络药理学及分子对接技术预测麦冬皂苷D(OP-D)治疗特发性肺纤维化(IPF)的作用机制,并进行细胞实验验证。方法(1)利用R软件的Limma包分析GEO数据库中IPF差异表达基因数据,筛选IPF疾病靶点;采用PharmMapper和SwissTa... 目的整合生物信息学、网络药理学及分子对接技术预测麦冬皂苷D(OP-D)治疗特发性肺纤维化(IPF)的作用机制,并进行细胞实验验证。方法(1)利用R软件的Limma包分析GEO数据库中IPF差异表达基因数据,筛选IPF疾病靶点;采用PharmMapper和SwissTargetPrediction数据库预测OP-D作用靶点;对筛选得到的OP-D作用靶点与IPF疾病靶点取交集,得到OP-D治疗IPF的潜在作用靶点。对潜在作用靶点进行GO功能及KEGG通路富集分析;采用STRING数据库和Cytoscape软件构建潜在作用靶点的蛋白互作(PPI)网络,并筛选OP-D抗IPF的核心靶点。使用Autodock Vina软件对OP-D与核心靶点进行分子对接验证。(2)采用TGF-β(10μg·L^(-1))诱导人胚肺成纤维细胞(HFL^(-1)),并用不同浓度OP-D进行干预。采用CCK-8法、EdU法检测细胞增殖情况;Transwell检测细胞迁移能力;TUNEL染色法检测细胞凋亡情况;Western Blot法检测细胞中相关蛋白的表达水平。结果(1)筛选得到IPF疾病靶点2040个,OP-D作用靶点408个,取交集得到30个OP-D治疗IPF的潜在作用靶点。OP-D抗IPF的生物过程主要在胶原蛋白分解代谢过程、胶原蛋白代谢过程、细胞外基质分解和对异生物刺激的反应方面;主要涉及通路包括肥厚型心肌病信号通路、类风湿性关节炎信号通路、松弛素信号通路、PPAR信号通路和IL^(-1)7信号通路等。进一步筛选得到IGF1、MMP1、MMP2、MMP3、MMP7、ACE、CCL5等OP-D抗IPF的核心靶点,分子对接显示OP-D与核心靶点均有较好的结合活性。(2)OP-D能浓度依赖性抑制HFL^(-1)细胞的活力,选择1、2、4μmol·L^(-1)OP-D进行后续实验。与正常对照组比较,TGF-β组细胞的EdU阳性率及迁移细胞数显著升高(P<0.01);TUNEL阳性率及Bax蛋白表达水平显著下降(P<0.01),Bcl-2、FN-1、α-SMA、CollagenⅠ、IGF1、MMP1、MMP2、MMP3、MMP7蛋白表达水平显著升高(P<0.05,P<0.01)。与TGF-β组比较,1、2、4μmol·L^(-1)OP-D组的细胞EdU阳性率与迁移细胞数显著降低(P<0.05,P<0.01),TUNEL阳性率及Bax蛋白表达水平显著升高(P<0.05,P<0.01),Bcl-2、IGF1、MMP1、MMP2、MMP3、MMP7蛋白表达水平显著下降(P<0.05,P<0.01);4μmol·L^(-1)OP-D组细胞的FN-1、CollagenⅠ蛋白表达水平显著下降(P<0.05,P<0.01);2、4μmol·L^(-1)OP-D组细胞的α-SMA蛋白表达水平显著下降(P<0.05,P<0.01)。结论OP-D可能通过抑制IGF1表达,降低MMPs表达水平,进而抑制HFL^(-1)细胞增殖、迁移、凋亡抵抗和纤维化,从而发挥抗IPF的作用。 展开更多
关键词 麦冬皂苷D 特发性肺纤维化 生物信息学 网络药理学 分子对接 实验验证 人胚肺成纤维细胞
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基于多尺度卷积神经网络的草莓畸变识别实验设计
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作者 闫静杰 李培原 +3 位作者 周晓阳 丁俊丰 王晨昱 卢官明 《实验科学与技术》 2025年第4期20-24,共5页
为培养学生的开发和应用实践能力,根据课程实验设置,该文设计了基于多尺度卷积神经网络的草莓畸变识别实验案例供学生学习和上机实践。为提高畸变草莓图像的识别能力,研究了多尺度卷积神经网络,并实现了一个草莓畸变图像识别算法。实验... 为培养学生的开发和应用实践能力,根据课程实验设置,该文设计了基于多尺度卷积神经网络的草莓畸变识别实验案例供学生学习和上机实践。为提高畸变草莓图像的识别能力,研究了多尺度卷积神经网络,并实现了一个草莓畸变图像识别算法。实验结果表明,该算法对于草莓畸变图像具有准确的识别能力,有效降低了光照和背景等因素的影响。通过该实验案例,加深了学生对人工智能知识的理解,培养了学生学习人工智能方向的兴趣,提高了学生的人工智能项目开发和应用能力。 展开更多
关键词 人工智能导论 电子信息工程专业 卷积神经网络 实验案例
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探讨开心散改善阿尔茨海默病的作用机制 被引量:5
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作者 何晓明 王晓彤 +8 位作者 闵冬雨 王欣欣 程美佳 刘勇明 鞠业涛 杨雅丽 袁常斌 于畅洋 张力 《中国实验方剂学杂志》 北大核心 2025年第1期20-29,共10页
目的:基于网络药理学、分子对接及动物实验验证,探讨开心散治疗阿尔茨海默病(AD)的作用机制。方法:①采用中药系统药理数据分析平台(TCMSP)和中医药百科全书(ETCM)数据库获取开心散的活性成分及靶点;利用GeneCards、在线人类孟德尔遗传... 目的:基于网络药理学、分子对接及动物实验验证,探讨开心散治疗阿尔茨海默病(AD)的作用机制。方法:①采用中药系统药理数据分析平台(TCMSP)和中医药百科全书(ETCM)数据库获取开心散的活性成分及靶点;利用GeneCards、在线人类孟德尔遗传数据库(OMIM)、TTD、PharmGKB和DrugBank数据库获取AD的相关靶点;对开心散的活性成分作用靶点与AD相关靶点取交集(共同靶点);STRING数据库对共同靶点进行网络互作分析,构筑蛋白质-蛋白质相互作用(PPI)网络;应用Cytoscape内的CytoNCA插件筛选出核心靶点;Metascape平台执行基因本体(GO)功能富集分析及京都基因与基因组百科全书(KEGG)通路富集分析;借助Cytoscape 3.8.2建立“药物-活性成分-靶点”互作网络;AutoDock Vina进行分子对接;②利用东莨菪碱(SCOP)造模,腹腔注射,每日1次。将32只雄性C57/BL6小鼠随机分为空白(CON)组(0.9%氯化钠,n=8)、模型(SCOP)组(3 mg·kg^(-1)·d^(-1),n=8)、盐酸多奈哌齐组(SCOP 3 mg·kg^(-1)·d^(-1)+盐酸多奈哌齐3 mg·kg^(-1)·d^(-1),n=8)、开心散组(SCOP 3 mg·kg^(-1)·d^(-1)+开心散6.5 g·kg^(-1)·d^(-1),n=8)。各组小鼠0.9%氯化钠、开心散或盐酸多奈哌齐灌胃给药,2次/d,连续14 d。采用Morris水迷宫实验观察小鼠学习记忆能力;苏木素-伊红(HE)染色法观察小鼠海马CA1区病理变化;酶联免疫吸附测定法(ELISA)测定小鼠血清乙酰胆碱(ACh)与乙酰胆碱酯酶(AChE)含量;蛋白免疫印迹法(Western blot)检测小鼠海马中信号转导和转录激活因子3(STAT3)、核转录因子(NF)-κB p65蛋白表达水平。结果:①共得到开心散73种活性成分,筛选出开心散对治疗AD的潜在作用靶点(共同靶点)578个;关键活性成分:山柰酚、吉九里香碱等;潜在核心靶点:STAT3、NF-κB p65等;GO功能富集分析得到3124条生物功能、254条细胞构件、461条分子功能;KEGG通路富集分析获得248条通路,主要涉及癌症相关通路、TRP通路、环磷酸腺苷(cAMP)通路、NF-κB通路等;分子对接显示,关键活性成分与目标靶点结合力较稳定。②Morris水迷宫实验表示开心散可以改善SCOP诱导的小鼠学习记忆能力;HE染色及ELISA检测结果表明开心散对小鼠中枢神经损伤有改善;Western blot检测表明开心散对SCOP模型小鼠海马组织中NF-κB p65磷酸化与STAT3磷酸化水平有下调作用。结论:开心散可以改善SCOP模型小鼠的认知障碍功能,并且可能通过调节NF-κB p65、STAT3等靶点来参与NF-κB信号通路等,减少海马神经元损伤从而发挥治疗AD的作用。 展开更多
关键词 开心散 阿尔茨海默病 网络药理学 分子对接 东莨菪碱 作用机制 实验验证
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基于虚拟技术的电路实验平台设计
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作者 崔双喜 马百强 《中国现代教育装备》 2025年第11期40-43,共4页
虚拟技术因方便快捷、工作效率高,在实验教学中得到广泛的应用。为满足特殊情况下电路实验远程教学需求和辅助教学,分别从五个方面完成了虚拟电路实验平台的设计:基于LabVIEW的实验登录界面、基于Access和LabVIEW的数据库建设及用户管... 虚拟技术因方便快捷、工作效率高,在实验教学中得到广泛的应用。为满足特殊情况下电路实验远程教学需求和辅助教学,分别从五个方面完成了虚拟电路实验平台的设计:基于LabVIEW的实验登录界面、基于Access和LabVIEW的数据库建设及用户管理模块、基于LabVIEW的仿真实验模块、实验报告模块、网络化实现。经过针对不同建设目标的调试和试运行,实验平台均取得预期的效果。 展开更多
关键词 LABVIEW 虚拟电路实验 网络化 实验平台 设计与实现
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新工科背景下计算机网络实验课程建设
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作者 边胜琴 刘羽飞 +2 位作者 王丽娜 崔晓龙 皇甫伟 《计算机教育》 2025年第12期262-267,共6页
为加深学生对计算机网络知识的理解,提高工程实践能力和创新能力,在新工科教育理念指导下,提出“虚实训”三结合实验教学模式,包括真实实验与虚拟实验相结合、真实设备与开源软件相结合、实验教学与项目实训相结合,具体操作包括模块化... 为加深学生对计算机网络知识的理解,提高工程实践能力和创新能力,在新工科教育理念指导下,提出“虚实训”三结合实验教学模式,包括真实实验与虚拟实验相结合、真实设备与开源软件相结合、实验教学与项目实训相结合,具体操作包括模块化教学内容、规范教学流程、定义考核标准等,结合校园网设计案例,介绍教学实施流程,阐述教学效果保障措施,实践证明该实验教学方法有助于提高学生创新能力。 展开更多
关键词 新工科建设 教学改革 人才培养 实验教学 计算机网络
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基于深度Q网络的平衡杆优化控制实验教学案例设计
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作者 钟珊 杜鑫 +2 位作者 司亚利 刘井莲 严卫 《实验室研究与探索》 北大核心 2025年第1期146-152,190,共8页
为了使学生更深入地掌握采用强化学习求解任务最优策略的方法,基于深度Q网络设计了平衡杆的控制优化实验。将平衡杆实验环境建模为马尔可夫决策模型,从深度Q网络结构、探索策略、奖励函数、经验回放池更新和目标Q网络更新等角度进行了... 为了使学生更深入地掌握采用强化学习求解任务最优策略的方法,基于深度Q网络设计了平衡杆的控制优化实验。将平衡杆实验环境建模为马尔可夫决策模型,从深度Q网络结构、探索策略、奖励函数、经验回放池更新和目标Q网络更新等角度进行了实验方案的设计。实验评估综合考虑了算法有效性、Q值估计的准确性、样本效率和Q网络的损失估计。在此基础上,将其与基准算法Q学习算法在累计奖赏和学习效率上进行了对比。该实验不仅可以帮助学生学会综合应用强化学习知识,也能帮助其掌握采用深度Q网络算法来求解离散动作空间任务的最优策略。 展开更多
关键词 强化学习 深度Q网络 Q学习 平衡杆 实验设计
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