BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.展开更多
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o...Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
Previous work puts forward a random edge rewiring method which is capable of improving the network robustness noticeably, while it lacks further discussions about how to improve the robustness faster. In this study, t...Previous work puts forward a random edge rewiring method which is capable of improving the network robustness noticeably, while it lacks further discussions about how to improve the robustness faster. In this study, the detailed analysis of the structures of improved networks show that regenerating the edges between high-degree nodes can enhance the robustness against a targeted attack. Therefore, we propose a novel rewiring strategy based on regenerating more edges between high-degree nodes, called smart rewiring, which could speed up the increase of the robustness index effectively. The smart rewiring method also explains why positive degree-degree correlation could enhance network robustness.展开更多
A demodulator based on convolutional neural networks（ CNNs） is proposed to demodulate bipolar extended binary phase shifting keying（ EBPSK） signals transmitted at a faster-thanNyquist（ FTN） rate, solving the pro...A demodulator based on convolutional neural networks（ CNNs） is proposed to demodulate bipolar extended binary phase shifting keying（ EBPSK） signals transmitted at a faster-thanNyquist（ FTN） rate, solving the problem of severe inter symbol interference（ ISI） caused by FTN rate signals. With the characteristics of local connectivity, pooling and weight sharing,a six-layer CNNs structure is used to demodulate and eliminate ISI. The results showthat with the symbol rate of 1. 07 k Bd, the bandwidth of the band-pass filter（ BPF） in a transmitter of 1 k Hz and the changing number of carrier cycles in a symbol K = 5,10,15,28, the overall bit error ratio（ BER） performance of CNNs with single-symbol decision is superior to that with a doublesymbol united-decision. In addition, the BER performance of single-symbol decision is approximately 0. 5 d B better than that of the coherent demodulator while K equals the total number of carrier circles in a symbol, i. e., K = N = 28. With the symbol rate of 1. 07 k Bd, the bandwidth of BPF in a transmitter of 500 Hz and K = 5,10,15,28, the overall BER performance of CNNs with double-symbol united-decision is superior to those with single-symbol decision. Moreover, the double-symbol uniteddecision method is approximately 0. 5 to 1. 5 d B better than that of the coherent demodulator while K = N = 28. The demodulators based on CNNs successfully solve the serious ISI problems generated during the transmission of FTN rate bipolar EBPSK signals, which is beneficial for the improvement of spectrum efficiency.展开更多
基金Supported by Key Research and Development Program of Shaanxi Province,China,No.2024SF-YBXM-078.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.
基金supported by grants from the National Natural Science Foundation of China(82004252)the Project of Administration of Traditional Chinese Medicine of Guangdong Province(202405112017596500)the Basic and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau(202102020533).
文摘Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
基金Supported by the Open Cooperation Research in National University of Defense Technology(NUDT)under Grant No 2014021the Graduate Innovation Fund of NUDT under Grant No B150501
文摘Previous work puts forward a random edge rewiring method which is capable of improving the network robustness noticeably, while it lacks further discussions about how to improve the robustness faster. In this study, the detailed analysis of the structures of improved networks show that regenerating the edges between high-degree nodes can enhance the robustness against a targeted attack. Therefore, we propose a novel rewiring strategy based on regenerating more edges between high-degree nodes, called smart rewiring, which could speed up the increase of the robustness index effectively. The smart rewiring method also explains why positive degree-degree correlation could enhance network robustness.
基金The National Natural Science Foundation of China(No.6504000089)
文摘A demodulator based on convolutional neural networks（ CNNs） is proposed to demodulate bipolar extended binary phase shifting keying（ EBPSK） signals transmitted at a faster-thanNyquist（ FTN） rate, solving the problem of severe inter symbol interference（ ISI） caused by FTN rate signals. With the characteristics of local connectivity, pooling and weight sharing,a six-layer CNNs structure is used to demodulate and eliminate ISI. The results showthat with the symbol rate of 1. 07 k Bd, the bandwidth of the band-pass filter（ BPF） in a transmitter of 1 k Hz and the changing number of carrier cycles in a symbol K = 5,10,15,28, the overall bit error ratio（ BER） performance of CNNs with single-symbol decision is superior to that with a doublesymbol united-decision. In addition, the BER performance of single-symbol decision is approximately 0. 5 d B better than that of the coherent demodulator while K equals the total number of carrier circles in a symbol, i. e., K = N = 28. With the symbol rate of 1. 07 k Bd, the bandwidth of BPF in a transmitter of 500 Hz and K = 5,10,15,28, the overall BER performance of CNNs with double-symbol united-decision is superior to those with single-symbol decision. Moreover, the double-symbol uniteddecision method is approximately 0. 5 to 1. 5 d B better than that of the coherent demodulator while K = N = 28. The demodulators based on CNNs successfully solve the serious ISI problems generated during the transmission of FTN rate bipolar EBPSK signals, which is beneficial for the improvement of spectrum efficiency.
