In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic h...In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic heterogeneous infrastructures,unstable links and non-uniform hardware capabilities create critical issues regarding security and privacy.Traditional protocols are often too computationally heavy to allow 6G services to achieve their expected Quality-of-Service(QoS).As the transport network is built of ad hoc nodes,there is no guarantee about their trustworthiness or behavior,and transversal functionalities are delegated to the extreme nodes.However,while security can be guaranteed in extreme-to-extreme solutions,privacy cannot,as all intermediate nodes still have to handle the data packets they are transporting.Besides,traditional schemes for private anonymous ad hoc communications are vulnerable against modern intelligent attacks based on learning models.The proposed scheme fulfills this gap.Findings show the probability of a successful intelligent attack reduces by up to 65%compared to ad hoc networks with no privacy protection strategy when used the proposed technology.While congestion probability can remain below 0.001%,as required in 6G services.展开更多
Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relati...Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relationships among nodes.This paper proposes a novel graph coupling convolutional model that introduces an adaptive weighting mechanism to assign distinct importance to neighboring nodes based on their similarity to the central node.Unlike traditional methods,the proposed coupling strategy enhances the interpretability of node interactions while maintaining competitive classification performance.The model operates in the spatial domain,utilizing adjacency list structures for efficient convolution and addressing the limitations of weight sharing through a coupling-based similarity computation.Extensive experiments are conducted on five graph-structured datasets,including Cora,Citeseer,PubMed,Reddit,and BlogCatalog,as well as a custom topology dataset constructed from the Open University Learning Analytics Dataset(OULAD)educational platform.Results demonstrate that the proposed model achieves good classification accuracy,while significantly reducing training time through direct second-order neighbor fusion and data preprocessing.Moreover,analysis of neighborhood order reveals that considering third-order neighbors offers limited accuracy gains but introduces considerable computational overhead,confirming the efficiency of first-and second-order convolution in practical applications.Overall,the proposed graph coupling model offers a lightweight,interpretable,and effective framework for multi-label node classification in complex networks.展开更多
In recent years,the rapid development of mega-constellations has significantly exacerbated the deterioration of the space debris environment,posing substantial and escalating threats to the safety of spacecraft.This s...In recent years,the rapid development of mega-constellations has significantly exacerbated the deterioration of the space debris environment,posing substantial and escalating threats to the safety of spacecraft.This study aims to explore the complex evolution of the space debris environment and assess the collision risks associated with spacecraft.First,a space debris environment topological network model is proposed,which incorporates interdisciplinary methods from topological networks,fluid mechanics,and spacecraft dynamics.This model enables a structured representation of the relationships among space objects and provides rapid predictions of the space debris environment.Then,a collision probability algorithm based on the topological network model is introduced.This algorithm inherits the efficiency advantages of the topological network model and has been validated for reliability through comparison with the classical ESA’s DRAMA software.Finally,based on the above models,the collision risks of constellation satellites in Low Earth Orbit(LEO)are analyzed,including both operational and deorbit processes.The study reveals that constellation satellites face a much higher risk of internal collisions with satellites from the same constellation during operations than that with other space objects.Additionally,during the satellite deorbit process,the collision risk peaks when satellites traverse the operational region of Starlink satellites.展开更多
It is well known that aluminum and copper exhibit structural phase transformations in quasi-static and dynamic measurements,including shock wave loading.However,the dependence of phase transformations in a wide range ...It is well known that aluminum and copper exhibit structural phase transformations in quasi-static and dynamic measurements,including shock wave loading.However,the dependence of phase transformations in a wide range of crystallographic directions of shock loading has not been revealed.In this work,we calculated the shock Hugoniot for aluminum and copper in different crystallographic directions([100],[110],[111],[112],[102],[114],[123],[134],[221]and[401])of shock compression using molecular dynamics(MD)simulations.The results showed a high pressure(>160 GPa for Cu and>40 GPa for Al)of the FCC-to-BCC transition.In copper,different characteristics of the phase transition are observed depending on the loading direction with the[100]compression direction being the weakest.The FCC-to-BCC transition for copper is in the range of 150–220 GPa,which is consistent with the existing experimental data.Due to the high transition pressure,the BCC phase transition in copper competes with melting.In aluminum,the FCC-to-BCC transition is observed for all studied directions at pressures between 40 and 50 GPa far beyond the melting.In all considered cases we observe the coexistence of HCP and BCC phases during the FCC-to-BCC transition,which is consistent with the experimental data and atomistic calculations;this HCP phase forms in the course of accompanying plastic deformation with dislocation activity in the parent FCC phase.The plasticity incipience is also anisotropic in bothmetals,which is due to the difference in the projections of stress on the slip plane for different orientations of the FCC crystal.MD modeling results demonstrate a strong dependence of the FCC-to-BCC transition on the crystallographic direction,in which the material is loaded in the copper crystals.However,MD simulations data can only be obtained for specific points in the stereographic direction space;therefore,for more comprehensive understanding of the phase transition process,a feed-forward neural network was trained using MD modeling data.The trained machine learning model allowed us to construct continuous stereographic maps of phase transitions as a function of stress in the shock-compressed state of metal.Due to appearance and growth of multiple centers of new phase,the FCC-to-BCC transition leads to formation of a polycrystalline structure from the parent single crystal.展开更多
Advances in Alzheimer's disease(AD)research have deepened our understanding,yet the mechanisms driving its progression remain unclear.Although a range of in vivo biomarkers is now available(e.g.,measurements of am...Advances in Alzheimer's disease(AD)research have deepened our understanding,yet the mechanisms driving its progression remain unclear.Although a range of in vivo biomarkers is now available(e.g.,measurements of amyloidbeta(Aβ)and ta u accumulation-the molecular hallmarks of AD-structural magnetic resonance imaging(MRI),assessments of brain metabolism,and,more recently,blood-based markers),a definitive diagnosis of AD continues to be challenging.For example,Frisoni et al.展开更多
Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefor...Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefore,this paper analyzes the spatial interaction between urban scale hierarchy and urban networks in China from 2019 to 2023,drawing on Baidu migration data and employing a spatial simultaneous equation model.The results reveal a significant positive spatial correlation between cities with higher hierarchy and those with greater network centrality.Within a static framework,we identify a positive interaction between urban scale hierarchy and urban network centrality,while their spatial cross-effects manifest as negative neighborhood interactions based on geographical distance and positive cross-scale interactions shaped by network connections.Within a dynamic framework,changes in urban scale hierarchy and urban networks are mutually reinforcing,thereby widening disparities within the urban hierarchy.Furthermore,an increase in a city’s network centrality had a dampening effect on the population growth of neighboring cities and network-connected cities.This study enhances understanding of the spatial organisation of urban systems and offers insights for coordinated regional development.展开更多
The effective channeling of fluid flow by fractures is a liability for enhanced oil recovery(EOR)methods like CO_(2) flooding or CO_(2) storage.Developing a distributed fracture model to understand the heterogeneity o...The effective channeling of fluid flow by fractures is a liability for enhanced oil recovery(EOR)methods like CO_(2) flooding or CO_(2) storage.Developing a distributed fracture model to understand the heterogeneity of the fracture network is essential in characterizing tight and low-permeability reservoirs.In the Ordos Basin,the Chang 8-1-2 layer of the Yanchang Formation is a typical tight and low permeability reservoir in the JH17 wellblock.The strong heterogeneity of distributed fractures,differing fracture scales and fracture types make it difficult to effectively characterize the fracture distribution within the Chang 8-1-2 layer.In this paper,multi-source and multi-attribute methods are used to integrate data into a neural network at different scales,and fuzzy logic control is used to judge the correlation of various attributes.The results suggest that attribute correlation between coherence and fracture indication is the best,followed by correlations with fault distance,north–south slope,and north–south curvature.Advantageous attributes from the target area are used to train the neural network,and the fracture density model and discrete fracture network(DFN)model are built at different scales.This method can be used to effectively predict the distribution characteristics of fractures in the study area.And any learning done by the neural network from this case study can be applied to fracture network modeling for reservoirs of the same type.展开更多
Based on analyzing the limitations of the commonly used back-propagation neural network （BPNN）, a wavelet neural network （WNN） is adopted as the nonlinear river channel flood forecasting method replacing the BPNN....Based on analyzing the limitations of the commonly used back-propagation neural network （BPNN）, a wavelet neural network （WNN） is adopted as the nonlinear river channel flood forecasting method replacing the BPNN. The WNN has the characteristics of fast convergence and improved capability of nonlinear approximation. For the purpose of adapting the timevarying characteristics of flood routing, the WNN is coupled with an AR real-time correction model. The AR model is utilized to calculate the forecast error. The coefficients of the AR real-time correction model are dynamically updated by an adaptive fading factor recursive least square（RLS） method. The application of the flood forecasting method in the cross section of Xijiang River at Gaoyao shows its effectiveness.展开更多
The aim of the present study was to investigate the modeling and prediction of the high temperature flow characteristics of a cast magnesium(Mg-Al-Ca)alloy by both constitutive equation and ANN model.Toward this end,h...The aim of the present study was to investigate the modeling and prediction of the high temperature flow characteristics of a cast magnesium(Mg-Al-Ca)alloy by both constitutive equation and ANN model.Toward this end,hot compression experiments were performed in 250-450℃and in strain rates of 0.001-1 s^(−1).The true stress of alloy was first and foremost described by the hyperbolic sine function in an Arrhenius-type of constitutive equation taking the effects of strain,strain rate and temperature into account.Predictions indicated that unlike low strain rates and high temperature with dominant DRX activation,in relatively high strain rate and low temperature values,the precision of the models become decreased due to activation of twinning phenomenon.At that moment and for a better evaluation of twinning effect during deformation,a feed-forward back propagation ANN was developed to study the flow behavior of the investigated alloy.Then,the performance of the two suggested models has been assessed using a statistical criterion.The comparative assessment of the gained results specifies that the well-trained ANN is much more precise and accurate than the constitutive equations in predicting the hot flow behavior.展开更多
In this work,a frame work for time-varying channel modeling and simulation is proposed by using neural network(NN)to overcome the shortcomings in geometry based stochastic model(GBSM)and simulation approach.Two NN mod...In this work,a frame work for time-varying channel modeling and simulation is proposed by using neural network(NN)to overcome the shortcomings in geometry based stochastic model(GBSM)and simulation approach.Two NN models are developed for modeling of path loss together with shadow fading(SF)and joint small scale channel parameters.The NN models can predict path loss plus SF and small scale channel parameters accurately compared with measurement at 26 GHz performed in an outdoor microcell.The time-varying path loss and small scale channel parameters generated by the NN models are proposed to replace the empirical path loss and channel parameter random numbers in GBSM-based framework to playback the measured channel and match with its environment.Moreover,the sparse feature of clusters,delay and angular spread,channel capacity are investigated by a virtual array measurement at 28 GHz in a large waiting hall.展开更多
Landslide susceptibility mapping(LSM)plays a crucial role in assessing geological risks.The current LSM techniques face a significant challenge in achieving accurate results due to uncertainties associated with region...Landslide susceptibility mapping(LSM)plays a crucial role in assessing geological risks.The current LSM techniques face a significant challenge in achieving accurate results due to uncertainties associated with regional-scale geotechnical parameters.To explore rainfall-induced LSM,this study proposes a hybrid model that combines the physically-based probabilistic model(PPM)with convolutional neural network(CNN).The PPM is capable of effectively capturing the spatial distribution of landslides by incorporating the probability of failure(POF)considering the slope stability mechanism under rainfall conditions.This significantly characterizes the variation of POF caused by parameter uncertainties.CNN was used as a binary classifier to capture the spatial and channel correlation between landslide conditioning factors and the probability of landslide occurrence.OpenCV image enhancement technique was utilized to extract non-landslide points based on the POF of landslides.The proposed model comprehensively considers physical mechanics when selecting non-landslide samples,effectively filtering out samples that do not adhere to physical principles and reduce the risk of overfitting.The results indicate that the proposed PPM-CNN hybrid model presents a higher prediction accuracy,with an area under the curve(AUC)value of 0.85 based on the landslide case of the Niangniangba area of Gansu Province,China compared with the individual CNN model(AUC=0.61)and the PPM(AUC=0.74).This model can also consider the statistical correlation and non-normal probability distributions of model parameters.These results offer practical guidance for future research on rainfall-induced LSM at the regional scale.展开更多
Integration of digital twin(DT)and wireless channel provides new solution of channel modeling and simulation,and can assist to design,optimize and evaluate intelligent wireless communication system and networks.With D...Integration of digital twin(DT)and wireless channel provides new solution of channel modeling and simulation,and can assist to design,optimize and evaluate intelligent wireless communication system and networks.With DT channel modeling,the generated channel data can be closer to realistic channel measurements without requiring a prior channel model,and amount of channel data can be significantly increased.Artificial intelligence(AI)based modeling approach shows outstanding performance to solve such problems.In this work,a channel modeling method based on generative adversarial networks is proposed for DT channel,which can generate identical statistical distribution with measured channel.Model validation is conducted by comparing DT channel characteristics with measurements,and results show that DT channel leads to fairly good agreement with measured channel.Finally,a link-layer simulation is implemented based on DT channel.It is found that the proposed DT channel model can be well used to conduct link-layer simulation and its performance is comparable to using measurement data.The observations and results can facilitate the development of DT channel modeling and provide new thoughts for DT channel applications,as well as improving the performance and reliability of intelligent communication networking.展开更多
The constitutive models of shape memory alloys(SMAs)play an important role in facilitating the widespread application of such types of alloys in various engineering fields.However,to accurately describe the deformatio...The constitutive models of shape memory alloys(SMAs)play an important role in facilitating the widespread application of such types of alloys in various engineering fields.However,to accurately describe the deformation behaviors of SMAs,the concepts in classical plasticity are employed in the existing constitutive models,and a series of complex mathematical equations are involved.Such complexity brings inconvenience for the construction,implementation,and application of the constitutive models.To overcome these shortcomings,a data-driven constitutive model of SMAs is developed in this work based on the artificial neural network(ANN).In the proposed model,the components of the strain tensor in principal space,ambient temperature,and the maximum equivalent strain in the deformation history from the initial state to the current loading state are chosen as the input features,and the components of the stress tensor in principal space are set as the output.The proposed ANN-based constitutive model is implemented into the finite element program ABAQUS by deriving its consistent tangent modulus and writing a user-defined material subroutine.The stress-strain responses of SMA material under various loading paths and at different ambient temperatures are used to train the ANN model,which is generated from the existing constitutive model(numerical experiments).To validate the capability of the proposed model,the predicted stress-strain responses of SMA material,and the global and local responses of two typical SMA structures are compared with the corresponding numerical experiments.This work demonstrates a good potential to obtain the constitutive model of SMAs by pure data and avoid the need for vast stores of knowledge for the construction of constitutive models.展开更多
Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many ...Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many resources and takes too long to compute,while neural network forecasting lacks regional data to train regional forecasting models.In this study,we used the DUAL wind model to build typhoon wind fields,and constructed a typhoon database of 75 processes in the northern South China Sea using the coupled Advanced Circulation-Simulating Waves Nearshore(ADCIRC-SWAN)model.Then,a neural network with a Res-U-Net structure was trained using the typhoon database to forecast the typhoon processes in the validation dataset,and an excellent storm surge forecasting effect was achieved in the Pearl River Estuary region.The storm surge forecasting effect of stronger typhoons was improved by adding a branch structure and transfer learning.展开更多
Climate models are vital for understanding and projecting global climate change and its associated impacts.However,these models suffer from biases that limit their accuracy in historical simulations and the trustworth...Climate models are vital for understanding and projecting global climate change and its associated impacts.However,these models suffer from biases that limit their accuracy in historical simulations and the trustworthiness of future projections.Addressing these challenges requires addressing internal variability,hindering the direct alignment between model simulations and observations,and thwarting conventional supervised learning methods.Here,we employ an unsupervised Cycle-consistent Generative Adversarial Network(CycleGAN),to correct daily Sea Surface Temperature(SST)simulations from the Community Earth System Model 2(CESM2).Our results reveal that the CycleGAN not only corrects climatological biases but also improves the simulation of major dynamic modes including the El Niño-Southern Oscillation(ENSO)and the Indian Ocean Dipole mode,as well as SST extremes.Notably,it substantially corrects climatological SST biases,decreasing the globally averaged Root-Mean-Square Error(RMSE)by 58%.Intriguingly,the CycleGAN effectively addresses the well-known excessive westward bias in ENSO SST anomalies,a common issue in climate models that traditional methods,like quantile mapping,struggle to rectify.Additionally,it substantially improves the simulation of SST extremes,raising the pattern correlation coefficient(PCC)from 0.56 to 0.88 and lowering the RMSE from 0.5 to 0.32.This enhancement is attributed to better representations of interannual,intraseasonal,and synoptic scales variabilities.Our study offers a novel approach to correct global SST simulations and underscores its effectiveness across different time scales and primary dynamical modes.展开更多
This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV i...This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered class.The total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,respectively.The proposed model is tested separately for unique solutions and existence on bi intervals.The numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons Polynomial.The proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler Law.The cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said disease.This study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered 1000.The obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately.展开更多
Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important a...Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important and scarce network resources such as bandwidth and processing power.There have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial losses.This paper draws its motivation from such real network disaster incidents attributed to signaling storms.In this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and countermeasures.We provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding solutions.Another important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a table.This paper presents an update and an extension of our earlier conference publication.To our knowledge,no similar survey study exists on the subject.展开更多
With the rapid development of Internet of Things technology,the sharp increase in network devices and their inherent security vulnerabilities present a stark contrast,bringing unprecedented challenges to the field of ...With the rapid development of Internet of Things technology,the sharp increase in network devices and their inherent security vulnerabilities present a stark contrast,bringing unprecedented challenges to the field of network security,especially in identifying malicious attacks.However,due to the uneven distribution of network traffic data,particularly the imbalance between attack traffic and normal traffic,as well as the imbalance between minority class attacks and majority class attacks,traditional machine learning detection algorithms have significant limitations when dealing with sparse network traffic data.To effectively tackle this challenge,we have designed a lightweight intrusion detection model based on diffusion mechanisms,named Diff-IDS,with the core objective of enhancing the model’s efficiency in parsing complex network traffic features,thereby significantly improving its detection speed and training efficiency.The model begins by finely filtering network traffic features and converting them into grayscale images,while also employing image-flipping techniques for data augmentation.Subsequently,these preprocessed images are fed into a diffusion model based on the Unet architecture for training.Once the model is trained,we fix the weights of the Unet network and propose a feature enhancement algorithm based on feature masking to further boost the model’s expressiveness.Finally,we devise an end-to-end lightweight detection strategy to streamline the model,enabling efficient lightweight detection of imbalanced samples.Our method has been subjected to multiple experimental tests on renowned network intrusion detection benchmarks,including CICIDS 2017,KDD 99,and NSL-KDD.The experimental results indicate that Diff-IDS leads in terms of detection accuracy,training efficiency,and lightweight metrics compared to the current state-of-the-art models,demonstrating exceptional detection capabilities and robustness.展开更多
Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better under...Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms.Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss.Our study uses the prematurely aged PolgD257A/D257A(PolgA)mouse model to scrutinize age-and sex-related alterations in musculoskeletal health parameters(frailty,grip strength,gait data),bone and particularly the osteocyte lacuno-canalicular network(LCN).Moreover,a new quantitative in silico image analysis pipeline is used to evaluate the alterations in the osteocyte network with aging.Our findings underscore the pronounced degenerative changes in the musculoskeletal health parameters,bone,and osteocyte LCN in PolgA mice as early as 40 weeks,with more prominent alterations evident in aged males.Our findings suggest that the PolgA mouse model serves as a valuable model for studying the cellular mechanisms underlying age-related bone loss,given the comparable aging signs and age-related degeneration of the bone and the osteocyte network observed in naturally aging mice and elderly humans.展开更多
[Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a...[Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a guide,we simulated pyruvate production of E.coli,screened key genes in metabolic pathways,and developed gene editing procedures accordingly.We knocked out the acetate kinase gene ackA,phosphate acetyltransferase gene pta,alcohol dehydrogenase adhE,glycogen synthase gene glgA,glycogen phosphorylase gene glgP,phosphoribosyl pyrophosphate(PRPP)synthase gene prs,ribose 1,5-bisphosphate phosphokinase gene phnN,and transporter encoding gene proP.Furthermore,we knocked in the transporter encoding gene ompC,flavonoid toxin gene fldA,and D-serine ammonia lyase gene dsdA.[Results]A shake flask process with the genetically edited mutant strain MG1655-6-2 under anaerobic conditions produced pyruvate at a titer of 10.46 g/L and a yield of 0.69 g/g.Metabolomic analysis revealed a significant increase in the pyruvate level in the fermentation broth,accompanied by notable decreases in the levels of certain related metabolic byproducts.Through 5 L fed-batch fermentation and an adaptive laboratory evolution,the strain finally achieved a pyruvate titer of 45.86 g/L.[Conclusion]This study illustrated the efficacy of a gene editing strategy predicted by a genome-scale metabolic network model in enhancing pyruvate accumulation in E.coli under anaerobic conditions and provided novel insights for microbial metabolic engineering.展开更多
基金funding from the European Commission by the Ruralities project(grant agreement no.101060876).
文摘In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic heterogeneous infrastructures,unstable links and non-uniform hardware capabilities create critical issues regarding security and privacy.Traditional protocols are often too computationally heavy to allow 6G services to achieve their expected Quality-of-Service(QoS).As the transport network is built of ad hoc nodes,there is no guarantee about their trustworthiness or behavior,and transversal functionalities are delegated to the extreme nodes.However,while security can be guaranteed in extreme-to-extreme solutions,privacy cannot,as all intermediate nodes still have to handle the data packets they are transporting.Besides,traditional schemes for private anonymous ad hoc communications are vulnerable against modern intelligent attacks based on learning models.The proposed scheme fulfills this gap.Findings show the probability of a successful intelligent attack reduces by up to 65%compared to ad hoc networks with no privacy protection strategy when used the proposed technology.While congestion probability can remain below 0.001%,as required in 6G services.
基金Support by Sichuan Science and Technology Program[2023YFSY0026,2023YFH0004]Guangzhou Huashang University[2024HSZD01,HS2023JYSZH01].
文摘Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relationships among nodes.This paper proposes a novel graph coupling convolutional model that introduces an adaptive weighting mechanism to assign distinct importance to neighboring nodes based on their similarity to the central node.Unlike traditional methods,the proposed coupling strategy enhances the interpretability of node interactions while maintaining competitive classification performance.The model operates in the spatial domain,utilizing adjacency list structures for efficient convolution and addressing the limitations of weight sharing through a coupling-based similarity computation.Extensive experiments are conducted on five graph-structured datasets,including Cora,Citeseer,PubMed,Reddit,and BlogCatalog,as well as a custom topology dataset constructed from the Open University Learning Analytics Dataset(OULAD)educational platform.Results demonstrate that the proposed model achieves good classification accuracy,while significantly reducing training time through direct second-order neighbor fusion and data preprocessing.Moreover,analysis of neighborhood order reveals that considering third-order neighbors offers limited accuracy gains but introduces considerable computational overhead,confirming the efficiency of first-and second-order convolution in practical applications.Overall,the proposed graph coupling model offers a lightweight,interpretable,and effective framework for multi-label node classification in complex networks.
基金supported by the National Level Project of China(No.KJSP2023020201)the Foundation of Science and Technology on Aerospace Flight Dynamics Laboratory of China(No.kjw6142210240202)+1 种基金the Beijing Institute of Technology Research Fund Program for Young Scholars of Chinathe Fundamental Research Funds for Central Universities of China。
文摘In recent years,the rapid development of mega-constellations has significantly exacerbated the deterioration of the space debris environment,posing substantial and escalating threats to the safety of spacecraft.This study aims to explore the complex evolution of the space debris environment and assess the collision risks associated with spacecraft.First,a space debris environment topological network model is proposed,which incorporates interdisciplinary methods from topological networks,fluid mechanics,and spacecraft dynamics.This model enables a structured representation of the relationships among space objects and provides rapid predictions of the space debris environment.Then,a collision probability algorithm based on the topological network model is introduced.This algorithm inherits the efficiency advantages of the topological network model and has been validated for reliability through comparison with the classical ESA’s DRAMA software.Finally,based on the above models,the collision risks of constellation satellites in Low Earth Orbit(LEO)are analyzed,including both operational and deorbit processes.The study reveals that constellation satellites face a much higher risk of internal collisions with satellites from the same constellation during operations than that with other space objects.Additionally,during the satellite deorbit process,the collision risk peaks when satellites traverse the operational region of Starlink satellites.
基金founded by the Ministry of Science and Higher Education of the Russian Federation,State assignments for research,registration No.1024032600084-8-1.3.2Study of the grain growth and the formation of polycrystalline structure as a result of phase transition(Section 6)was founded by the Russian Science Foundation,Project No.24-71-00078+3 种基金https://rscf.ru/en/project/24-71-00078/(accessed on 01 December 2025).Study of the orientation dependence of the phase transition of aluminum in Section 3 was founded by the Russian Science Foundation,Project No.24-19-00684https://rscf.ru/en/project/24-19-00684/(accessed on 01 December 2025).
文摘It is well known that aluminum and copper exhibit structural phase transformations in quasi-static and dynamic measurements,including shock wave loading.However,the dependence of phase transformations in a wide range of crystallographic directions of shock loading has not been revealed.In this work,we calculated the shock Hugoniot for aluminum and copper in different crystallographic directions([100],[110],[111],[112],[102],[114],[123],[134],[221]and[401])of shock compression using molecular dynamics(MD)simulations.The results showed a high pressure(>160 GPa for Cu and>40 GPa for Al)of the FCC-to-BCC transition.In copper,different characteristics of the phase transition are observed depending on the loading direction with the[100]compression direction being the weakest.The FCC-to-BCC transition for copper is in the range of 150–220 GPa,which is consistent with the existing experimental data.Due to the high transition pressure,the BCC phase transition in copper competes with melting.In aluminum,the FCC-to-BCC transition is observed for all studied directions at pressures between 40 and 50 GPa far beyond the melting.In all considered cases we observe the coexistence of HCP and BCC phases during the FCC-to-BCC transition,which is consistent with the experimental data and atomistic calculations;this HCP phase forms in the course of accompanying plastic deformation with dislocation activity in the parent FCC phase.The plasticity incipience is also anisotropic in bothmetals,which is due to the difference in the projections of stress on the slip plane for different orientations of the FCC crystal.MD modeling results demonstrate a strong dependence of the FCC-to-BCC transition on the crystallographic direction,in which the material is loaded in the copper crystals.However,MD simulations data can only be obtained for specific points in the stereographic direction space;therefore,for more comprehensive understanding of the phase transition process,a feed-forward neural network was trained using MD modeling data.The trained machine learning model allowed us to construct continuous stereographic maps of phase transitions as a function of stress in the shock-compressed state of metal.Due to appearance and growth of multiple centers of new phase,the FCC-to-BCC transition leads to formation of a polycrystalline structure from the parent single crystal.
文摘Advances in Alzheimer's disease(AD)research have deepened our understanding,yet the mechanisms driving its progression remain unclear.Although a range of in vivo biomarkers is now available(e.g.,measurements of amyloidbeta(Aβ)and ta u accumulation-the molecular hallmarks of AD-structural magnetic resonance imaging(MRI),assessments of brain metabolism,and,more recently,blood-based markers),a definitive diagnosis of AD continues to be challenging.For example,Frisoni et al.
基金Under the auspices of the National Natural Science Foundation of China(No.42371222,41971167)Fundamental Scientific Research Funds of Central China Normal University(No.CCNU24ZZ120)。
文摘Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefore,this paper analyzes the spatial interaction between urban scale hierarchy and urban networks in China from 2019 to 2023,drawing on Baidu migration data and employing a spatial simultaneous equation model.The results reveal a significant positive spatial correlation between cities with higher hierarchy and those with greater network centrality.Within a static framework,we identify a positive interaction between urban scale hierarchy and urban network centrality,while their spatial cross-effects manifest as negative neighborhood interactions based on geographical distance and positive cross-scale interactions shaped by network connections.Within a dynamic framework,changes in urban scale hierarchy and urban networks are mutually reinforcing,thereby widening disparities within the urban hierarchy.Furthermore,an increase in a city’s network centrality had a dampening effect on the population growth of neighboring cities and network-connected cities.This study enhances understanding of the spatial organisation of urban systems and offers insights for coordinated regional development.
基金supported by the National Science and Technology Project of China(No.2024ZD1004300)。
文摘The effective channeling of fluid flow by fractures is a liability for enhanced oil recovery(EOR)methods like CO_(2) flooding or CO_(2) storage.Developing a distributed fracture model to understand the heterogeneity of the fracture network is essential in characterizing tight and low-permeability reservoirs.In the Ordos Basin,the Chang 8-1-2 layer of the Yanchang Formation is a typical tight and low permeability reservoir in the JH17 wellblock.The strong heterogeneity of distributed fractures,differing fracture scales and fracture types make it difficult to effectively characterize the fracture distribution within the Chang 8-1-2 layer.In this paper,multi-source and multi-attribute methods are used to integrate data into a neural network at different scales,and fuzzy logic control is used to judge the correlation of various attributes.The results suggest that attribute correlation between coherence and fracture indication is the best,followed by correlations with fault distance,north–south slope,and north–south curvature.Advantageous attributes from the target area are used to train the neural network,and the fracture density model and discrete fracture network(DFN)model are built at different scales.This method can be used to effectively predict the distribution characteristics of fractures in the study area.And any learning done by the neural network from this case study can be applied to fracture network modeling for reservoirs of the same type.
基金The National Natural Science Foundation of China(No.50479017).
文摘Based on analyzing the limitations of the commonly used back-propagation neural network （BPNN）, a wavelet neural network （WNN） is adopted as the nonlinear river channel flood forecasting method replacing the BPNN. The WNN has the characteristics of fast convergence and improved capability of nonlinear approximation. For the purpose of adapting the timevarying characteristics of flood routing, the WNN is coupled with an AR real-time correction model. The AR model is utilized to calculate the forecast error. The coefficients of the AR real-time correction model are dynamically updated by an adaptive fading factor recursive least square（RLS） method. The application of the flood forecasting method in the cross section of Xijiang River at Gaoyao shows its effectiveness.
文摘The aim of the present study was to investigate the modeling and prediction of the high temperature flow characteristics of a cast magnesium(Mg-Al-Ca)alloy by both constitutive equation and ANN model.Toward this end,hot compression experiments were performed in 250-450℃and in strain rates of 0.001-1 s^(−1).The true stress of alloy was first and foremost described by the hyperbolic sine function in an Arrhenius-type of constitutive equation taking the effects of strain,strain rate and temperature into account.Predictions indicated that unlike low strain rates and high temperature with dominant DRX activation,in relatively high strain rate and low temperature values,the precision of the models become decreased due to activation of twinning phenomenon.At that moment and for a better evaluation of twinning effect during deformation,a feed-forward back propagation ANN was developed to study the flow behavior of the investigated alloy.Then,the performance of the two suggested models has been assessed using a statistical criterion.The comparative assessment of the gained results specifies that the well-trained ANN is much more precise and accurate than the constitutive equations in predicting the hot flow behavior.
基金supported by the National Nature Science Foundation of China(NSFC)under grant No.61771194supported by Key Program of Beijing Municipal Natural Science Foundation with No.17L20052
文摘In this work,a frame work for time-varying channel modeling and simulation is proposed by using neural network(NN)to overcome the shortcomings in geometry based stochastic model(GBSM)and simulation approach.Two NN models are developed for modeling of path loss together with shadow fading(SF)and joint small scale channel parameters.The NN models can predict path loss plus SF and small scale channel parameters accurately compared with measurement at 26 GHz performed in an outdoor microcell.The time-varying path loss and small scale channel parameters generated by the NN models are proposed to replace the empirical path loss and channel parameter random numbers in GBSM-based framework to playback the measured channel and match with its environment.Moreover,the sparse feature of clusters,delay and angular spread,channel capacity are investigated by a virtual array measurement at 28 GHz in a large waiting hall.
基金funding support from the National Natural Science Foundation of China(Grant Nos.U22A20594,52079045)Hong-Zhi Cui acknowledges the financial support of the China Scholarship Council(Grant No.CSC:202206710014)for his research at Universitat Politecnica de Catalunya,Barcelona.
文摘Landslide susceptibility mapping(LSM)plays a crucial role in assessing geological risks.The current LSM techniques face a significant challenge in achieving accurate results due to uncertainties associated with regional-scale geotechnical parameters.To explore rainfall-induced LSM,this study proposes a hybrid model that combines the physically-based probabilistic model(PPM)with convolutional neural network(CNN).The PPM is capable of effectively capturing the spatial distribution of landslides by incorporating the probability of failure(POF)considering the slope stability mechanism under rainfall conditions.This significantly characterizes the variation of POF caused by parameter uncertainties.CNN was used as a binary classifier to capture the spatial and channel correlation between landslide conditioning factors and the probability of landslide occurrence.OpenCV image enhancement technique was utilized to extract non-landslide points based on the POF of landslides.The proposed model comprehensively considers physical mechanics when selecting non-landslide samples,effectively filtering out samples that do not adhere to physical principles and reduce the risk of overfitting.The results indicate that the proposed PPM-CNN hybrid model presents a higher prediction accuracy,with an area under the curve(AUC)value of 0.85 based on the landslide case of the Niangniangba area of Gansu Province,China compared with the individual CNN model(AUC=0.61)and the PPM(AUC=0.74).This model can also consider the statistical correlation and non-normal probability distributions of model parameters.These results offer practical guidance for future research on rainfall-induced LSM at the regional scale.
基金supported by National Key R&D Program of China under Grant 2021YFB3901302 and 2021YFB2900301the National Natural Science Foundation of China under Grant 62271037,62001519,62221001,and U21A20445+1 种基金the State Key Laboratory of Advanced Rail Autonomous Operation under Grant RCS2022ZZ004the Fundamental Research Funds for the Central Universities under Grant 2022JBQY004.
文摘Integration of digital twin(DT)and wireless channel provides new solution of channel modeling and simulation,and can assist to design,optimize and evaluate intelligent wireless communication system and networks.With DT channel modeling,the generated channel data can be closer to realistic channel measurements without requiring a prior channel model,and amount of channel data can be significantly increased.Artificial intelligence(AI)based modeling approach shows outstanding performance to solve such problems.In this work,a channel modeling method based on generative adversarial networks is proposed for DT channel,which can generate identical statistical distribution with measured channel.Model validation is conducted by comparing DT channel characteristics with measurements,and results show that DT channel leads to fairly good agreement with measured channel.Finally,a link-layer simulation is implemented based on DT channel.It is found that the proposed DT channel model can be well used to conduct link-layer simulation and its performance is comparable to using measurement data.The observations and results can facilitate the development of DT channel modeling and provide new thoughts for DT channel applications,as well as improving the performance and reliability of intelligent communication networking.
基金supported by the National Natural Science Foundation of China(NSFC)(Grant No.12322203).
文摘The constitutive models of shape memory alloys(SMAs)play an important role in facilitating the widespread application of such types of alloys in various engineering fields.However,to accurately describe the deformation behaviors of SMAs,the concepts in classical plasticity are employed in the existing constitutive models,and a series of complex mathematical equations are involved.Such complexity brings inconvenience for the construction,implementation,and application of the constitutive models.To overcome these shortcomings,a data-driven constitutive model of SMAs is developed in this work based on the artificial neural network(ANN).In the proposed model,the components of the strain tensor in principal space,ambient temperature,and the maximum equivalent strain in the deformation history from the initial state to the current loading state are chosen as the input features,and the components of the stress tensor in principal space are set as the output.The proposed ANN-based constitutive model is implemented into the finite element program ABAQUS by deriving its consistent tangent modulus and writing a user-defined material subroutine.The stress-strain responses of SMA material under various loading paths and at different ambient temperatures are used to train the ANN model,which is generated from the existing constitutive model(numerical experiments).To validate the capability of the proposed model,the predicted stress-strain responses of SMA material,and the global and local responses of two typical SMA structures are compared with the corresponding numerical experiments.This work demonstrates a good potential to obtain the constitutive model of SMAs by pure data and avoid the need for vast stores of knowledge for the construction of constitutive models.
基金supported by the National Natural Science Foundation of China(Grant No.42076214)Natural Science Foundation of Shandong Province(Grant No.ZR2024QD057).
文摘Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many resources and takes too long to compute,while neural network forecasting lacks regional data to train regional forecasting models.In this study,we used the DUAL wind model to build typhoon wind fields,and constructed a typhoon database of 75 processes in the northern South China Sea using the coupled Advanced Circulation-Simulating Waves Nearshore(ADCIRC-SWAN)model.Then,a neural network with a Res-U-Net structure was trained using the typhoon database to forecast the typhoon processes in the validation dataset,and an excellent storm surge forecasting effect was achieved in the Pearl River Estuary region.The storm surge forecasting effect of stronger typhoons was improved by adding a branch structure and transfer learning.
基金supported by the National Natural Science Foundation of China(Grant Nos.42141019 and 42261144687)the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(Grant No.2019QZKK0102)+4 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB42010404)the National Natural Science Foundation of China(Grant No.42175049)the Guangdong Meteorological Service Science and Technology Research Project(Grant No.GRMC2021M01)the National Key Scientific and Technological Infrastructure project“Earth System Science Numerical Simulator Facility”(EarthLab)for computational support and Prof.Shiming XIANG for many useful discussionsNiklas BOERS acknowledges funding from the Volkswagen foundation.
文摘Climate models are vital for understanding and projecting global climate change and its associated impacts.However,these models suffer from biases that limit their accuracy in historical simulations and the trustworthiness of future projections.Addressing these challenges requires addressing internal variability,hindering the direct alignment between model simulations and observations,and thwarting conventional supervised learning methods.Here,we employ an unsupervised Cycle-consistent Generative Adversarial Network(CycleGAN),to correct daily Sea Surface Temperature(SST)simulations from the Community Earth System Model 2(CESM2).Our results reveal that the CycleGAN not only corrects climatological biases but also improves the simulation of major dynamic modes including the El Niño-Southern Oscillation(ENSO)and the Indian Ocean Dipole mode,as well as SST extremes.Notably,it substantially corrects climatological SST biases,decreasing the globally averaged Root-Mean-Square Error(RMSE)by 58%.Intriguingly,the CycleGAN effectively addresses the well-known excessive westward bias in ENSO SST anomalies,a common issue in climate models that traditional methods,like quantile mapping,struggle to rectify.Additionally,it substantially improves the simulation of SST extremes,raising the pattern correlation coefficient(PCC)from 0.56 to 0.88 and lowering the RMSE from 0.5 to 0.32.This enhancement is attributed to better representations of interannual,intraseasonal,and synoptic scales variabilities.Our study offers a novel approach to correct global SST simulations and underscores its effectiveness across different time scales and primary dynamical modes.
基金supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU)(grant number IMSIU-RP23066).
文摘This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered class.The total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,respectively.The proposed model is tested separately for unique solutions and existence on bi intervals.The numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons Polynomial.The proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler Law.The cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said disease.This study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered 1000.The obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately.
基金the Deanship of Graduate Studies and Scientific Research at Qassim University for financial support(QU-APC-2024-9/1).
文摘Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important and scarce network resources such as bandwidth and processing power.There have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial losses.This paper draws its motivation from such real network disaster incidents attributed to signaling storms.In this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and countermeasures.We provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding solutions.Another important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a table.This paper presents an update and an extension of our earlier conference publication.To our knowledge,no similar survey study exists on the subject.
基金supported by the Key Research and Development Program of Hainan Province(Grant Nos.ZDYF2024GXJS014,ZDYF2023GXJS163)the National Natural Science Foundation of China(NSFC)(Grant Nos.62162022,62162024)Collaborative Innovation Project of Hainan University(XTCX2022XXB02).
文摘With the rapid development of Internet of Things technology,the sharp increase in network devices and their inherent security vulnerabilities present a stark contrast,bringing unprecedented challenges to the field of network security,especially in identifying malicious attacks.However,due to the uneven distribution of network traffic data,particularly the imbalance between attack traffic and normal traffic,as well as the imbalance between minority class attacks and majority class attacks,traditional machine learning detection algorithms have significant limitations when dealing with sparse network traffic data.To effectively tackle this challenge,we have designed a lightweight intrusion detection model based on diffusion mechanisms,named Diff-IDS,with the core objective of enhancing the model’s efficiency in parsing complex network traffic features,thereby significantly improving its detection speed and training efficiency.The model begins by finely filtering network traffic features and converting them into grayscale images,while also employing image-flipping techniques for data augmentation.Subsequently,these preprocessed images are fed into a diffusion model based on the Unet architecture for training.Once the model is trained,we fix the weights of the Unet network and propose a feature enhancement algorithm based on feature masking to further boost the model’s expressiveness.Finally,we devise an end-to-end lightweight detection strategy to streamline the model,enabling efficient lightweight detection of imbalanced samples.Our method has been subjected to multiple experimental tests on renowned network intrusion detection benchmarks,including CICIDS 2017,KDD 99,and NSL-KDD.The experimental results indicate that Diff-IDS leads in terms of detection accuracy,training efficiency,and lightweight metrics compared to the current state-of-the-art models,demonstrating exceptional detection capabilities and robustness.
基金the European Research Council(ERC Advanced MechAGE-ERC-2016-ADG-741883)the Swiss National Science Foundation(no.188522).
文摘Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms.Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss.Our study uses the prematurely aged PolgD257A/D257A(PolgA)mouse model to scrutinize age-and sex-related alterations in musculoskeletal health parameters(frailty,grip strength,gait data),bone and particularly the osteocyte lacuno-canalicular network(LCN).Moreover,a new quantitative in silico image analysis pipeline is used to evaluate the alterations in the osteocyte network with aging.Our findings underscore the pronounced degenerative changes in the musculoskeletal health parameters,bone,and osteocyte LCN in PolgA mice as early as 40 weeks,with more prominent alterations evident in aged males.Our findings suggest that the PolgA mouse model serves as a valuable model for studying the cellular mechanisms underlying age-related bone loss,given the comparable aging signs and age-related degeneration of the bone and the osteocyte network observed in naturally aging mice and elderly humans.
基金supported by the Hebei Provincial Key Research and Development Project(21372803D)。
文摘[Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a guide,we simulated pyruvate production of E.coli,screened key genes in metabolic pathways,and developed gene editing procedures accordingly.We knocked out the acetate kinase gene ackA,phosphate acetyltransferase gene pta,alcohol dehydrogenase adhE,glycogen synthase gene glgA,glycogen phosphorylase gene glgP,phosphoribosyl pyrophosphate(PRPP)synthase gene prs,ribose 1,5-bisphosphate phosphokinase gene phnN,and transporter encoding gene proP.Furthermore,we knocked in the transporter encoding gene ompC,flavonoid toxin gene fldA,and D-serine ammonia lyase gene dsdA.[Results]A shake flask process with the genetically edited mutant strain MG1655-6-2 under anaerobic conditions produced pyruvate at a titer of 10.46 g/L and a yield of 0.69 g/g.Metabolomic analysis revealed a significant increase in the pyruvate level in the fermentation broth,accompanied by notable decreases in the levels of certain related metabolic byproducts.Through 5 L fed-batch fermentation and an adaptive laboratory evolution,the strain finally achieved a pyruvate titer of 45.86 g/L.[Conclusion]This study illustrated the efficacy of a gene editing strategy predicted by a genome-scale metabolic network model in enhancing pyruvate accumulation in E.coli under anaerobic conditions and provided novel insights for microbial metabolic engineering.
