To the Editor:Stroke is among the leading public health problems in China,with high rates of recurrent stroke,cardiovascular events and mortality,resulting in a considerable medical and economic burden.[1]The identifi...To the Editor:Stroke is among the leading public health problems in China,with high rates of recurrent stroke,cardiovascular events and mortality,resulting in a considerable medical and economic burden.[1]The identification of new molecular markers and therapeutic targets is necessary to better refine the risk prediction of cardiovascular events and develop new treatment strategies for ischemic stroke.Succinate is a tricarboxylic acid(TCA)cycle intermediate and has received considerable attention for its involvement in various signaling pathways associated with cardiovascular diseases.[2–4]Recent studies have reported that succinate is a novel mediator that promotes atherosclerotic lesion progression,fibroblast activation,and apoptosis resistance.展开更多
基金This study was supported by the National Natural Science Foundation of China(Nos.82273706 and 82220108001)the Suzhou Science and Technology Project(No.SYW2024067)+1 种基金Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University(No.YXY2302013)the Project of MOE Key Laboratory of Geriatric Diseases and Immunology(No.JYN202406).
文摘To the Editor:Stroke is among the leading public health problems in China,with high rates of recurrent stroke,cardiovascular events and mortality,resulting in a considerable medical and economic burden.[1]The identification of new molecular markers and therapeutic targets is necessary to better refine the risk prediction of cardiovascular events and develop new treatment strategies for ischemic stroke.Succinate is a tricarboxylic acid(TCA)cycle intermediate and has received considerable attention for its involvement in various signaling pathways associated with cardiovascular diseases.[2–4]Recent studies have reported that succinate is a novel mediator that promotes atherosclerotic lesion progression,fibroblast activation,and apoptosis resistance.
