A new chloro-azaphilone derivative chaetoviridin L(1)along with four known analogues,namely,chaetomugilin A(2),chaetoviridin E(3),chaetomugilin O(4),and chaephilone D(5),is isolated and identified from the culture ext...A new chloro-azaphilone derivative chaetoviridin L(1)along with four known analogues,namely,chaetomugilin A(2),chaetoviridin E(3),chaetomugilin O(4),and chaephilone D(5),is isolated and identified from the culture extract of Chaetomium globosum YP-106,a deep-sea derived fungus obtained from the hadal zone seawater collected in the Yap Trench.Their structures were determined based on detailed interpretation of nuclear magnetic resonance(NMR)spectroscopic,mass spectrometry(MS)data analysis and comparison with the reported literature.The absolute configuration of the new compound was established by quantum chemical calculations of electronic circular dichroism(ECD).All the isolated compounds were evaluated for pro-angiogenesis activity using zebra fish model.Compounds 1,2,and 5significantly promoted the angiogenesis in a dose-dependent manner and thus,these compounds might be used as promising molecules for the treatment of cardiovascular disease.展开更多
This paper reports a research on teratoge-nesis and mutagenesis of BaCl<sub>3</sub>·2H<sub>2</sub>O. The teratogenic results showed that BaClcould decrease the weight of pregnant rats,incr...This paper reports a research on teratoge-nesis and mutagenesis of BaCl<sub>3</sub>·2H<sub>2</sub>O. The teratogenic results showed that BaClcould decrease the weight of pregnant rats,increase the numher of dead fetus and展开更多
大跨桥梁多模态涡激振动控制受限于传统线性吸振器的窄频特性。非线性能量阱惯容器(nonlinear energy sink inerter,NESI)结合宽频吸振与质量放大效应,具备多模态控制潜力,但其性能易受自质量、装配误差等附加位移影响。针对桥梁风致多...大跨桥梁多模态涡激振动控制受限于传统线性吸振器的窄频特性。非线性能量阱惯容器(nonlinear energy sink inerter,NESI)结合宽频吸振与质量放大效应,具备多模态控制潜力,但其性能易受自质量、装配误差等附加位移影响。针对桥梁风致多模态涡激振动控制,提出基于NESI的控制方法。通过理论分析与数值模拟,研究了附加位移效应对NESI控制性能的影响。研究表明,附加位移导致NESI刚度与阻尼的有效参数范围偏移,引发1∶2次频率比共振,涡激振动抑制效率降低53.7%。此外,相较于阻尼比,NESI的控制性能对桥梁模态频率和初始激励幅值更为敏感。当存在附加位移时,NESI控制性能对频率比和激励幅值变化均表现出显著退化,尤其在频率比小于1区域内性能波动剧烈。进一步研究表明,适当提高质量比与惯质比虽可在一定程度上缓解附加位移带来的性能损失,但在频率比小于1的条件下仍难以实现稳定控制。展开更多
Lesion mmic mutants(LMMs)are plants that spontaneously form lesions without pathogeninfection or external stimulus and exhibit resistance to pathogens.Here,a rice LMM was created by ethylmethane sulfonate mutagenesis,...Lesion mmic mutants(LMMs)are plants that spontaneously form lesions without pathogeninfection or external stimulus and exhibit resistance to pathogens.Here,a rice LMM was created by ethylmethane sulfonate mutagenesis,named as hpil(hydrogen peroxide induced lesion).Diaminobenzidineand trypan blue staining showed that large amounts of H_(2)O_(2) were produced and cell death was occurredat and around the parts of lesion mimic in the rice leaves.The phenotype of hpil is controlled by a singlerecessive gene,localized at a 2 Mb interval on chromosome 2.The data suggested that hpil is a novelLMM with enhanced bacterial and fungal disease resistance,and multiple pathogenesis-related proteins(PRs)were up-regulated.The proteomes of leaves at three positions(different degrees of lesion mimicseverity)were characterized in hpil compared with its wild type plant.Differentially expressed proteinswere detected by two dimensional difference gel electrophoresis and 274 proteins were identified byMALDITOF/TOFTM.These proteins were related to metabolic process,cellular process and response tostimulus,with mostly down-regulated in hpil leaves.Many of these proteins were related to the Calvincycle,photosynthetic electron transport chain,glycolysis/gluconeogenesis and phosphonates pathways.Some resistance-related proteins including 14-3-3 proteins,OsPR10 and antioxidases such asperoxidase,superoxide dismutase and ascorbate peroxidase were up-regulated in leaves with lesionmimic.These results provide the foundation for cloning of the target gene and shed light on themechanism involved in autaimmunity of rice.展开更多
Becker muscular dystrophy is a rather common X-linked recessiveneuromuscular disorder which affects 3-6/100thousand newbornboys.BMD is characterized by a milder clinical course which theaffected indivicuats live longe...Becker muscular dystrophy is a rather common X-linked recessiveneuromuscular disorder which affects 3-6/100thousand newbornboys.BMD is characterized by a milder clinical course which theaffected indivicuats live longer and later onset as comparedwith DMD.As a general rule,there are two kinds of originationfor the abnormal gene from those BMD families in which展开更多
Objective To explore the correlation of inflammation and destabilization of carotid plaque with acute ischemic stroke. Methods Seventy one patients with acute brain infarction (group A) , 44 with asymptomatic carotid ...Objective To explore the correlation of inflammation and destabilization of carotid plaque with acute ischemic stroke. Methods Seventy one patients with acute brain infarction (group A) , 44 with asymptomatic carotid atherosclerosis (group B) and 21 normal controls (group C) were investigated. The serum levels of soluble展开更多
基金Supported by the National Natural Science Foundation of China(No42006096)the Shandong Provincial Natural Science Foundation(No ZR2020QD098)the China Postdoctoral Science Foundation(No2020M682266)。
文摘A new chloro-azaphilone derivative chaetoviridin L(1)along with four known analogues,namely,chaetomugilin A(2),chaetoviridin E(3),chaetomugilin O(4),and chaephilone D(5),is isolated and identified from the culture extract of Chaetomium globosum YP-106,a deep-sea derived fungus obtained from the hadal zone seawater collected in the Yap Trench.Their structures were determined based on detailed interpretation of nuclear magnetic resonance(NMR)spectroscopic,mass spectrometry(MS)data analysis and comparison with the reported literature.The absolute configuration of the new compound was established by quantum chemical calculations of electronic circular dichroism(ECD).All the isolated compounds were evaluated for pro-angiogenesis activity using zebra fish model.Compounds 1,2,and 5significantly promoted the angiogenesis in a dose-dependent manner and thus,these compounds might be used as promising molecules for the treatment of cardiovascular disease.
文摘This paper reports a research on teratoge-nesis and mutagenesis of BaCl<sub>3</sub>·2H<sub>2</sub>O. The teratogenic results showed that BaClcould decrease the weight of pregnant rats,increase the numher of dead fetus and
文摘大跨桥梁多模态涡激振动控制受限于传统线性吸振器的窄频特性。非线性能量阱惯容器(nonlinear energy sink inerter,NESI)结合宽频吸振与质量放大效应,具备多模态控制潜力,但其性能易受自质量、装配误差等附加位移影响。针对桥梁风致多模态涡激振动控制,提出基于NESI的控制方法。通过理论分析与数值模拟,研究了附加位移效应对NESI控制性能的影响。研究表明,附加位移导致NESI刚度与阻尼的有效参数范围偏移,引发1∶2次频率比共振,涡激振动抑制效率降低53.7%。此外,相较于阻尼比,NESI的控制性能对桥梁模态频率和初始激励幅值更为敏感。当存在附加位移时,NESI控制性能对频率比和激励幅值变化均表现出显著退化,尤其在频率比小于1区域内性能波动剧烈。进一步研究表明,适当提高质量比与惯质比虽可在一定程度上缓解附加位移带来的性能损失,但在频率比小于1的条件下仍难以实现稳定控制。
基金supported by the Zhejiang Provincial Key Research and Development Plan(Grant No.2019C02006)the National Key Research and Development Program of China(Grant Nos.2016YFD0200804 and 2016YFD0100601-15)+2 种基金the Key Program of Zhejiang Provincial Foundation for Natural Science(Grant No.LZ16C130002)the Zhejiang Fundamental Public Welfare Research Program(Grant No.LGN19C140008)the State Key Laboratory for Managing Biotic and Chemical Threats to Quality and Safety of Agro-products(Grant No.2010DS700124-ZZ1907).
文摘Lesion mmic mutants(LMMs)are plants that spontaneously form lesions without pathogeninfection or external stimulus and exhibit resistance to pathogens.Here,a rice LMM was created by ethylmethane sulfonate mutagenesis,named as hpil(hydrogen peroxide induced lesion).Diaminobenzidineand trypan blue staining showed that large amounts of H_(2)O_(2) were produced and cell death was occurredat and around the parts of lesion mimic in the rice leaves.The phenotype of hpil is controlled by a singlerecessive gene,localized at a 2 Mb interval on chromosome 2.The data suggested that hpil is a novelLMM with enhanced bacterial and fungal disease resistance,and multiple pathogenesis-related proteins(PRs)were up-regulated.The proteomes of leaves at three positions(different degrees of lesion mimicseverity)were characterized in hpil compared with its wild type plant.Differentially expressed proteinswere detected by two dimensional difference gel electrophoresis and 274 proteins were identified byMALDITOF/TOFTM.These proteins were related to metabolic process,cellular process and response tostimulus,with mostly down-regulated in hpil leaves.Many of these proteins were related to the Calvincycle,photosynthetic electron transport chain,glycolysis/gluconeogenesis and phosphonates pathways.Some resistance-related proteins including 14-3-3 proteins,OsPR10 and antioxidases such asperoxidase,superoxide dismutase and ascorbate peroxidase were up-regulated in leaves with lesionmimic.These results provide the foundation for cloning of the target gene and shed light on themechanism involved in autaimmunity of rice.
文摘Becker muscular dystrophy is a rather common X-linked recessiveneuromuscular disorder which affects 3-6/100thousand newbornboys.BMD is characterized by a milder clinical course which theaffected indivicuats live longer and later onset as comparedwith DMD.As a general rule,there are two kinds of originationfor the abnormal gene from those BMD families in which
基金the National Natural Science Foundation of China(21775143,21475121)the Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2017FXCX003)+1 种基金Users with Excellence Project of Hefei Science Center CAS(2018HSC-UE001,2018HSC-UE016)the Fundamental Research Funds for the Central Universities.
文摘Objective To explore the correlation of inflammation and destabilization of carotid plaque with acute ischemic stroke. Methods Seventy one patients with acute brain infarction (group A) , 44 with asymptomatic carotid atherosclerosis (group B) and 21 normal controls (group C) were investigated. The serum levels of soluble
