AIM: To determine the clinicopathological characteristics of nonsteroidal anti-inflammatory drug (NSAID)-induced acute hepato-nephrotoxicity among Chinese patients.
Dear editor,The first extraction of a renal calculi through a percutaneous nephrostomy(PCNL)was described in 1976 by Fernstro¨m and Johansson[1].Through the collaboration of urology and interventional radiology,s...Dear editor,The first extraction of a renal calculi through a percutaneous nephrostomy(PCNL)was described in 1976 by Fernstro¨m and Johansson[1].Through the collaboration of urology and interventional radiology,several innovations were later made to improve what we know today as PCNL[2].Ever since PCNL was introduced,the basic concepts for stone treatment with a nephroscope were the need for good visualization,a method to fragment larger stones,and a mechanical means to remove the fragments.Initially we started with a 30-French instrument to meet those goals;the concept was to have a large enough channel to remove 1 cm stone fragments.This decision was arbitrary at the time,and not evidence based.展开更多
Dear editor,Cystic nephroma(CN)is a rare kind of tumor in the kidney,which has benign pathological features and biological behaviors but malignancy-like image manifestations.Pediatric CN is always associated with germ...Dear editor,Cystic nephroma(CN)is a rare kind of tumor in the kidney,which has benign pathological features and biological behaviors but malignancy-like image manifestations.Pediatric CN is always associated with germline DICER1 mutation and belongs to DICER1 syndrome,while adult CN which is now considered a different entity apparently has nothing to do with DICER1 mutation[1].The accurate preoperative diagnosis is of great importance in choosing proper treatment.This paper provides a case of adult CN as below.展开更多
Objectives: To evaluate the incidence of bladder cancer after nephro-ureterectomy (NUT) and determine the potential risk factors of bladder recurrence in patients with upper urinary tract urothelial carcinoma (UUT-UC)...Objectives: To evaluate the incidence of bladder cancer after nephro-ureterectomy (NUT) and determine the potential risk factors of bladder recurrence in patients with upper urinary tract urothelial carcinoma (UUT-UC). Materials and Methods: We retrospectively assessed 37 patients with UUT-UC including a significant follow-up after NUT of 34 months (range 12 - 120 months). The median age of the population was 72 years (range 48 - 83 years). Patients with a previous history of bladder cancer, concomitant diagnosis of bladder tumor and UUT-UC;or a metastatic UUT-UC were excluded from the study. Results: Out of these 37 patients, 17 presented a bladder recurrence within an average time of 12 months (range 3 to 31 months) after the NUT. In 94% of the cases, bladder recurrence occurred within the first 24 months following the NUT. Histological distribution was: 13 Ta tumors (76%), 2 pT1 tumors (11.7%);11 patients had a high stage lesion (76%), whereas 4 patients had a low stage lesion (23.5%). As regards the anatomo-pathological characteristics of the UUT-UC, the supra iliac localization of the tumor is a significant risk factor of bladder recurrence (p = 0.04). Conclusion: Bladder recurrence after NUT occurred frequently and could have possibly been under-estimated. The use of intra-vesical instillation of Mitomycin C after NUT has been recently recommended by the European Association of Urology, but no predictive factors have yet been identified. Early diagnosis of bladder recurrence could certainly have reduced mortality in this patient population.展开更多
基金Supported by National Natural Science Foundation of China,No.81200535China-Japan Friendship Hospital Youth Science and Technology Excellence Project,No.2014-QNYC-A-01
文摘AIM: To determine the clinicopathological characteristics of nonsteroidal anti-inflammatory drug (NSAID)-induced acute hepato-nephrotoxicity among Chinese patients.
文摘Dear editor,The first extraction of a renal calculi through a percutaneous nephrostomy(PCNL)was described in 1976 by Fernstro¨m and Johansson[1].Through the collaboration of urology and interventional radiology,several innovations were later made to improve what we know today as PCNL[2].Ever since PCNL was introduced,the basic concepts for stone treatment with a nephroscope were the need for good visualization,a method to fragment larger stones,and a mechanical means to remove the fragments.Initially we started with a 30-French instrument to meet those goals;the concept was to have a large enough channel to remove 1 cm stone fragments.This decision was arbitrary at the time,and not evidence based.
文摘Dear editor,Cystic nephroma(CN)is a rare kind of tumor in the kidney,which has benign pathological features and biological behaviors but malignancy-like image manifestations.Pediatric CN is always associated with germline DICER1 mutation and belongs to DICER1 syndrome,while adult CN which is now considered a different entity apparently has nothing to do with DICER1 mutation[1].The accurate preoperative diagnosis is of great importance in choosing proper treatment.This paper provides a case of adult CN as below.
文摘Objectives: To evaluate the incidence of bladder cancer after nephro-ureterectomy (NUT) and determine the potential risk factors of bladder recurrence in patients with upper urinary tract urothelial carcinoma (UUT-UC). Materials and Methods: We retrospectively assessed 37 patients with UUT-UC including a significant follow-up after NUT of 34 months (range 12 - 120 months). The median age of the population was 72 years (range 48 - 83 years). Patients with a previous history of bladder cancer, concomitant diagnosis of bladder tumor and UUT-UC;or a metastatic UUT-UC were excluded from the study. Results: Out of these 37 patients, 17 presented a bladder recurrence within an average time of 12 months (range 3 to 31 months) after the NUT. In 94% of the cases, bladder recurrence occurred within the first 24 months following the NUT. Histological distribution was: 13 Ta tumors (76%), 2 pT1 tumors (11.7%);11 patients had a high stage lesion (76%), whereas 4 patients had a low stage lesion (23.5%). As regards the anatomo-pathological characteristics of the UUT-UC, the supra iliac localization of the tumor is a significant risk factor of bladder recurrence (p = 0.04). Conclusion: Bladder recurrence after NUT occurred frequently and could have possibly been under-estimated. The use of intra-vesical instillation of Mitomycin C after NUT has been recently recommended by the European Association of Urology, but no predictive factors have yet been identified. Early diagnosis of bladder recurrence could certainly have reduced mortality in this patient population.
