BACKGROUND Renal angiomyolipoma and renal cell carcinoma are the most common benign and malignant tumors of the kidney respectively,and the preoperative differential diagnosis is crucial due to the wide difference in ...BACKGROUND Renal angiomyolipoma and renal cell carcinoma are the most common benign and malignant tumors of the kidney respectively,and the preoperative differential diagnosis is crucial due to the wide difference in treatment methods.Fat-poor renal angiomyolipoma is a relatively rare type of in renal angiomyolipoma.Its fat imaging features are not obvious,and it is easily misdiagnosed as renal cell carcinoma.CASE SUMMARY We report the case of a 41-year-old man who complained of osphyalgia.Subsequent abdominal computed tomography scans revealed that a heterogeneous mass was seen in the lower pole of the right kidney,with the size of about 53 mm×47 mm.And showed two right renal arteries,with the mass supplied by an ectopic vessel from the abdominal aorta.Fluorescent laparoscopic blockade of the right renal heterotopic artery and partial nephrectomy was performed.Based on histological and immunohistochemical findings,the tumor was diagnosed as fatpoor renal angiomyolipoma.CONCLUSION The use of fluorescent laparoscopy can effectively help intraoperative management,and the fluorescence pattern provided by intravenous indocyanine green can help suggest the final diagnosis,effectively guide the surgical decisionmaking,and avoid preoperative imaging diagnosis leading to nephrectomy for benign renal tumors,through fluorescent navigation of tumor supply vessel precise block,minimize the loss of renal function.展开更多
目的:研究缓衰方对纤维连接蛋白(FN)、转化生长因子β_2(TGF-β_2)在5/6肾切除大鼠肾小球中的含量的影响。方法:Wistar 大鼠5/6肾切除造模,随机分为对照组、缓衰方组,观察实验开始、第6周及第12周血肌酐(SCr)、24 h 尿蛋白定量变化,以...目的:研究缓衰方对纤维连接蛋白(FN)、转化生长因子β_2(TGF-β_2)在5/6肾切除大鼠肾小球中的含量的影响。方法:Wistar 大鼠5/6肾切除造模,随机分为对照组、缓衰方组,观察实验开始、第6周及第12周血肌酐(SCr)、24 h 尿蛋白定量变化,以及免疫组化加图像分析检测 FN、TGF-β_2的相对含量。结果:动物经5/6肾切除后,SCr、24 h 尿蛋白定量增加,经缓衰方灌胃12周,SCr、24 h 尿蛋白定量减少,与对照组比较,差异有显著性(P<0.05);免疫组化显示,缓衰方组 FN、TGF-β_2的相对含量较对照组明显降低,两组比较,差异亦有显著性(P<0.05)。结论:缓衰方通过抑制过高 TGF-β_2水平,而减少细胞外基质成分 FN 在肾小球的积聚,延缓肾衰进展速度,保护残肾功能。展开更多
Objective : To investigate the effect of Huan shuai Recipe on the expression level of fibronectin (FN) and transforming growth factor β 2 (TGF β 2 ) in the remnant kidney of rats. Methods : Male Wistar ra...Objective : To investigate the effect of Huan shuai Recipe on the expression level of fibronectin (FN) and transforming growth factor β 2 (TGF β 2 ) in the remnant kidney of rats. Methods : Male Wistar rats, after 4 weeks of 5/6 nephrectomy, were divided into two groups at random, and treated with water and Huanshuai Recipe (HSR) respectively. Serum creatinine (SCr) and urinary protein of 24 hours were observed at beginning, 6th week and 12th week of the experiment, and FN and TGF β 2 were assayed by immunohistochemical technique and computer assisted image analysis as well. Results : Serum SCr and urinary protein of 24 hours were increased significantly in the animals after 5/6 nephrectomy. The increased parameters decreased in the HSR group after treatment, as compared with those in the control group, and the difference was significant ( P <0.05 ); Immunohistochemical measurement and computer assisted image analysis showed a marked suppression of FN and TGF β 2 in animals of the HSR group with significant difference from those in the control group ( P <0.05). Conclusion : HSR not only plays the role of renal function protection, but could also alleviate the glomerular pathological injury. The effect on TGF β 2 and FN may be the mechanism of HSR in slowing down the progression of chronic renal failure.展开更多
文摘BACKGROUND Renal angiomyolipoma and renal cell carcinoma are the most common benign and malignant tumors of the kidney respectively,and the preoperative differential diagnosis is crucial due to the wide difference in treatment methods.Fat-poor renal angiomyolipoma is a relatively rare type of in renal angiomyolipoma.Its fat imaging features are not obvious,and it is easily misdiagnosed as renal cell carcinoma.CASE SUMMARY We report the case of a 41-year-old man who complained of osphyalgia.Subsequent abdominal computed tomography scans revealed that a heterogeneous mass was seen in the lower pole of the right kidney,with the size of about 53 mm×47 mm.And showed two right renal arteries,with the mass supplied by an ectopic vessel from the abdominal aorta.Fluorescent laparoscopic blockade of the right renal heterotopic artery and partial nephrectomy was performed.Based on histological and immunohistochemical findings,the tumor was diagnosed as fatpoor renal angiomyolipoma.CONCLUSION The use of fluorescent laparoscopy can effectively help intraoperative management,and the fluorescence pattern provided by intravenous indocyanine green can help suggest the final diagnosis,effectively guide the surgical decisionmaking,and avoid preoperative imaging diagnosis leading to nephrectomy for benign renal tumors,through fluorescent navigation of tumor supply vessel precise block,minimize the loss of renal function.
文摘目的:研究缓衰方对纤维连接蛋白(FN)、转化生长因子β_2(TGF-β_2)在5/6肾切除大鼠肾小球中的含量的影响。方法:Wistar 大鼠5/6肾切除造模,随机分为对照组、缓衰方组,观察实验开始、第6周及第12周血肌酐(SCr)、24 h 尿蛋白定量变化,以及免疫组化加图像分析检测 FN、TGF-β_2的相对含量。结果:动物经5/6肾切除后,SCr、24 h 尿蛋白定量增加,经缓衰方灌胃12周,SCr、24 h 尿蛋白定量减少,与对照组比较,差异有显著性(P<0.05);免疫组化显示,缓衰方组 FN、TGF-β_2的相对含量较对照组明显降低,两组比较,差异亦有显著性(P<0.05)。结论:缓衰方通过抑制过高 TGF-β_2水平,而减少细胞外基质成分 FN 在肾小球的积聚,延缓肾衰进展速度,保护残肾功能。
文摘Objective : To investigate the effect of Huan shuai Recipe on the expression level of fibronectin (FN) and transforming growth factor β 2 (TGF β 2 ) in the remnant kidney of rats. Methods : Male Wistar rats, after 4 weeks of 5/6 nephrectomy, were divided into two groups at random, and treated with water and Huanshuai Recipe (HSR) respectively. Serum creatinine (SCr) and urinary protein of 24 hours were observed at beginning, 6th week and 12th week of the experiment, and FN and TGF β 2 were assayed by immunohistochemical technique and computer assisted image analysis as well. Results : Serum SCr and urinary protein of 24 hours were increased significantly in the animals after 5/6 nephrectomy. The increased parameters decreased in the HSR group after treatment, as compared with those in the control group, and the difference was significant ( P <0.05 ); Immunohistochemical measurement and computer assisted image analysis showed a marked suppression of FN and TGF β 2 in animals of the HSR group with significant difference from those in the control group ( P <0.05). Conclusion : HSR not only plays the role of renal function protection, but could also alleviate the glomerular pathological injury. The effect on TGF β 2 and FN may be the mechanism of HSR in slowing down the progression of chronic renal failure.
