BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM ...BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM To explore the correlations among life satisfaction,pleasure levels,and negative emotions in patients with CRF.METHODS One hundred patients with CRF who received therapy at the First Affiliated Hospital of Jinzhou Medical University between December 2022 and February 2025 were included.The Depression,Anxiety,and Stress Scale(DASS-21),Satisfaction with Life Scale(SWLS),and Temporal Experience of Pleasure Scale(TEPS)were used to evaluate negative emotions,life satisfaction,and pleasure level,respectively.Pearson’s correlation coefficient analyzed the correlation between life satisfaction,pleasure level,and negative emotions.Linear regression analysis identified the factors affecting negative emotions.RESULTS The average DASS-21 score among patients with CRF was 51.90±2.30,with subscale scores of 17.90±1.50 for depression,18.53±1.18 for anxiety,and 15.47±2.36 for stress,all significantly higher than the domestic norm(P<0.05).The average SWLS score was 22.17±4.90.Correlation analysis revealed a negative correlation between the SWLS and total DASS-21 scores(P<0.05),but not with the individual depression,anxiety,or stress dimensions.The average TEPS score was 67.80±8.34.TEPS scores were negatively correlated with the DASS-21 score and the stress dimension(P<0.05),but not with depression or anxiety.Linear regression analysis showed that TEPS scores significantly influenced DASS-21 scores(P<0.05).CONCLUSION Patients with CRF experience high levels of negative emotions,which are negatively correlated with life satisfaction and pleasure.Furthermore,pleasure level had an impact on negative emotions.展开更多
A simplified approach was proposed to analyze the negative skin friction calculation of special-shaped pile considering pile-soil interaction under surcharge. Based on the concentric cylinder shearing theory, consider...A simplified approach was proposed to analyze the negative skin friction calculation of special-shaped pile considering pile-soil interaction under surcharge. Based on the concentric cylinder shearing theory, considering the changes of pile shape(such as, taper angle and diameters of pile base, etc.), the load-transfer of special-shaped pile was built. The accuracy of the developed simplified approach was verified by numerical simulation model with the same condition. Then, the influence factors, such as, taper angles, the diameter of pile base, surcharge, and pile-soil interface parameters were analyzed and discussed. The results show that the developed simplified approach can calculate NSF of special-shaped pile under surcharge effectively. A limited parametric study indicates that in many practical situations special-shaped piles(such as belled wedge pile shown in this work) offer a design option that is more economical than traditional uniform cross-section piles.展开更多
A series of model experiments of bucket foundations concerning suction installation and negative pressure consolidation in saturated silt were carried out in a cube steel bin at Tianjin University. The experimental re...A series of model experiments of bucket foundations concerning suction installation and negative pressure consolidation in saturated silt were carried out in a cube steel bin at Tianjin University. The experimental results show that the silt inside the bucket has been strengthened by negative pressure, and the strengthening effect decreases with the increase of the distance from the bucket. A three-dimensional numerical model of the experiments was built by means of finite element software ABAQUS with fluid-solid coupling method. The results show that the bearing capacity of the silt inside the bucket foundation increases significantly at the former stage of negative pressure consolidation, while the increasing trend slows down over time. The rotation centers of the bucket foundation and the inner soil region tend to be closer to each other based on the consolidation. The bearing capacity of the bucket foundation is improved effectively with the increase of soil strength. The effects of negative pressure consolidation on the bearing capacity of bucket foundation were also illustrated by an actual offshore wind power project case.展开更多
Objective： The aim of this study was to evaluate the anti-tumor activity and safety of Gemcitabine （GEM） combined with Vinorelbine （NVB） in patients with advanced TNABC after chemotherapy. Methods： Thirty-seven ...Objective： The aim of this study was to evaluate the anti-tumor activity and safety of Gemcitabine （GEM） combined with Vinorelbine （NVB） in patients with advanced TNABC after chemotherapy. Methods： Thirty-seven patients with immunohistochemical proved TNABC were enrolled. The patients received 21-day cycles of NVB 25mg/m^2 i.v. with GEM 1000 mg/m^2 i.v. on days 1 and 8. Results： A total of 136 cycles were given to 37 patients（median 4 cycles, ranged 2-6 cycles）. The treatment response was evaluable in all patients. Of the 37 patients, 1 received complete remission （CR）, 8 received partial remission （PR）, 20 had stable disease （SD）, 9 had progressive disease （PD）. Overall objective response （CR＋ PR） were 24.3 %. The median time to progress （TTP） was 6 months （95% CI, 4-6 months）. The median overall survival was 24 months （95% CI, 11-37 months）. The median 1-year survival rate was （66.24±8.43）%. The median 3-year survival rate was （28.77±11.96）%. The major adverse events were grade Ⅰ-Ⅱ myelosuppression, peripheral neurologic toxicities, nausea and vomiting. Some patients had rash and hepatic dysfunction. A total of 40% of patients experienced flu-like symptoms. Alopecia and diarrhea were rare. Conclusion： The combination of GEM and NVB is an effective and well tolerated regimen for the patients with TNABC.展开更多
Cover-bearing-type bucket foundation for offshore wind turbines has been paid more and more attention due to its low cost and great bearing capacity. In order to ensure the cover-bearing mode, the muddy soil inside th...Cover-bearing-type bucket foundation for offshore wind turbines has been paid more and more attention due to its low cost and great bearing capacity. In order to ensure the cover-bearing mode, the muddy soil inside the bucket foundation should be reinforced by some soil consolidation methods, such as negative pressure and electro-osmosis. Firstly, tests were conducted to obtain the reasonable current density. Meanwhile, to improve the electro-osmotic speed and effectiveness, other factors such as intermittent power and layout of electrode, were also studied in the tests. Then, the soil reinforcing tests by negative pressure combined with electro-osmosis were performed for the muddy soil consolidation inside the bucket foundation. The results showed that soil reinforcement by negative pressure was quicker and more obvious during the early phase, and electro-osmotic method can affect more range of soil by rational arrangement of electrodes. Compared with negative pressure, the electro-osmotic method was a continuous and relatively slow process of reinforcement, which was complementary to the negative pressure method. The voltage value of electro-osmosis had little effect on the muddy soil reinforcement inside the bucket foundation, and 1.5 A was chosen as the most reasonable current value for scale model testing in the electro-osmotic method.展开更多
The mechanisms of streamer generation and propagation in double-sided pulsed surface dielectric barrier discharge(SDBD)on both sides have been analyzed and investigated by experiment and numerical simulation.The fully...The mechanisms of streamer generation and propagation in double-sided pulsed surface dielectric barrier discharge(SDBD)on both sides have been analyzed and investigated by experiment and numerical simulation.The fully exposed asymmetric SDBD has two discharge processes located on the high voltage electrode(HVE)side and the ground electrode(GE)side.Discharge images of the HVE side and GE side are taken by a digital camera under continuous pulse and ICCD(Intensified Charge Coupled Device)is utilized to diagnose the generation and propagation of streamers in single pulse discharge.In order to understand the physical mechanisms of streamer evolution more deeply,we establish a 2D simulation model and analyze it from the aspects of electron density,ion density,reduced electric field and electron impact ionization source term.The results show that the primary and secondary discharges on the HVE side and the GE side of the double-sided SDBD are composed of positive streamer and negative streamer,respectively.On the HVE side,the accumulation of positive charges on the dielectric surface causes the direction of the electric field to reverse,which is the principal factor for the polarity reversal of the streamer.On the GE side,both the negative charges accumulated on the dielectric surface and the falling voltage are the key factors for the streamer polarity switch.展开更多
An Electromagnetic (EM) radiation in dispersion less free space vacuum is represented by a photon, with corpuscular and wave nature. The discussions, for the past century aimed at the nature of photon inside a media h...An Electromagnetic (EM) radiation in dispersion less free space vacuum is represented by a photon, with corpuscular and wave nature. The discussions, for the past century aimed at the nature of photon inside a media having dispersion in the refraction property, other than free space. What about its nature if the space be of refractive index which is negative, is discussed in this paper. We call mechanical momentum, wave-momentum, and try to match our present theories with intriguing property of this ‘photon’ or pulse carrying EM energy packet, and more so we try to find its property energy, momentum inside a media a positive refractive media, and if the media show a negative refractive index behavior, then these queries are profound, and suitable explanations to these classical concepts of corpuscular-wave nature of photon inside these media are quest for the scientists dealing with these materials having negative index of refraction. Here some of this counterintuitive nature of corpuscular-wave nature of photon inside negative indexed material is brought out, with possible ‘new definition’ of its ‘wave-momentum’, the concept of ‘reactive energy’ inside negative indexed material, along with possible ‘new wave equation’. These definitions and expressions of ‘wave-momentum’ and ‘reactive energy’ pertaining to negative indexed material are new and discussed and derived by classical means.展开更多
BACKGROUND The number of tumor deposits(TDs)does not play a part in the current tumor node metastasis staging.Negative lymph node(NLN)status is associated with the prognosis of colorectal cancer(CRC),but its clear rol...BACKGROUND The number of tumor deposits(TDs)does not play a part in the current tumor node metastasis staging.Negative lymph node(NLN)status is associated with the prognosis of colorectal cancer(CRC),but its clear role in N1c stage remains to be defined.AIM To evaluate the combination of TDs and NLNs as potential prognostic indicators in N1c CRC.METHODS We retrospectively identified 107 consecutive patients who had N1c CRC radically resected at China-Japan Friendship Hospital.The combination of TDs and NLNs was calculated by the formula NLNTD=NLN/(TD+1).Cutoff values of NLNs and NLNTD were determined using the R package“survminer”.Disease-free survival(DFS),overall survival(OS)and cancer-specific survival(CSS)were determined using the Kaplan-Meier method to assess the impact of NLNTD on prognosis.Results were compared using the log-rank test.RESULTS The median follow-up time was 63.17(45.33-81.37)months for DFS,with 33.64%(36/107)of patients experiencing recurrence during follow-up.Five-year DFS was 66.0%(57.3%-76.0%).There was no significant difference in prognosis between patients with>12 and≤12 NLNs(P=0.058)for DFS.Similar results were seen according to the number of TDs.The definition of NLNTD=NLN/(TD+1)with a cutoff value of 6 divided patients into two groups with different DFS(P=0.005).Five-year DFS for patients with NLNTD>6 was 73.5%(63.6%-85.0%),compared with 50.0%(35.7%-70.0%)for those with NLNTD≤6.These two groups had different prognosis without perineural invasion(P=0.012)or lymphovascular invasion(P=0.002)even neither(P=0.053).Similar results were seen for OS and CSS.CONCLUSION NLNTD could serve as important prognostic factor for outcomes in N1c CRC patients.These patients could be stratified for prognosis through NLNTD and the high-risk should be given more attention during treatment.展开更多
Minimizing the thermal expansion coefficient(TEC)mismatch between the cathode and electrolyte in solid oxide fuel cells is crucial for achieving stable,durable operation and high performance.Recently,materials with ne...Minimizing the thermal expansion coefficient(TEC)mismatch between the cathode and electrolyte in solid oxide fuel cells is crucial for achieving stable,durable operation and high performance.Recently,materials with negative thermal expansion(NTE)have at-tracted significant attention as effective additives for tailoring the thermomechanical properties of electrodes and enhancing cell durability.In this work,for the first time,single-phase NTE perovskite Sm_(0.85)Zn_(0.15)MnO_(3−δ)(SZM15)was successfully synthesized via the sol-gel method,eliminating the unwanted ZnO phase typically observed in materials obtained through the conventional solid-state reaction route.The sol-gel approach proved highly advantageous,offering low cost,robustness,excellent chemical homogeneity,precise compositional control,and high phase purity.After optimization of synthesis parameters,a negative TEC of approximately−6.5×10^(−6)K^(−1)was achieved in the 400-850℃range.SZM15 was then incorporated as an additive(10wt%-50wt%)into a SmBa0.5Sr0.5CoCuO_(5+δ)(SBSCCO)cathode to tune the thermomechanical properties with a La_(0.8)Sr_(0.2)Ga_(0.8)Mg_(0.2)O_(3−δ)(LSGM)electrolyte,achieving a minimal TEC mismatch of only 1%.Notably,the SBSCCO+10wt%SZM15 composite cathode exhibited the lowest polarization resistance of 0.019Ω·cm^(2)at 900℃,showing approximately 70%lower than that of the pristine cathode.Excellent long-term stability after 100 h of operation was achieved.In addition,a high peak power density of 680 mW·cm^(−2)was achieved in a Ni-YSZ(yttria-stabilized zirconia)|YSZ|Ce_(0.9)Gd_(0.1)O_(2−δ)(GDC10)|SBSCCO+10wt%SZM15 anode-supported fuel cell at 850℃,highlighting the effectiveness of incorporating NTE materials as a promising strategy for regulating the thermomechanical properties and improving the long-term stability of intermediate temperature solid oxide fuel cells(IT-SOFCs).展开更多
Negative thermal expansion(NTE)is a notable physical property where a material’s volume decreases instead of increasing when heated.The identification of NTE materials is crucial for thermal expansion control enginee...Negative thermal expansion(NTE)is a notable physical property where a material’s volume decreases instead of increasing when heated.The identification of NTE materials is crucial for thermal expansion control engineering.Most NTE materials exhibit NTE only within a narrow temperature range,restricting their applications.Achieving NTE across a broad temperature range remains a significant challenge.This study developed a novel PbTiO_(3)-based system,(1-x)PbTiO_(3–x)BiLuO_(3),incorporating rare-earth elements,using a distinctive high-pressure and high-temperature synthesis technique.We achieved NTE across a broad temperature range by coupling lattice(c/a)with ferroelectric order parameters.The incorporation of BiLuO_(3)resulted in distinctive ferroelectric characteristics,including increased tetragonality,spontaneous polarization,and NTE over a broad temperature range.NTE over an extended temperature range has been achieved in 0.95PbTiO_(3)–0.05BiLuO_(3)(■=−1.7×10^(–5)K^(−1),300–840 K)and 0.90PbTiO_(3)–0.10BiLuO_(3)(■=−1.4×10^(–5)K^(−1),300–860 K),compared to pristine PbTiO_(3)(■=−1.99×10^(–5)K^(−1),300–763 K).The improved tetragonalities and broader NTE temperature range result from the strong hybridization of Pb/Bi–O and Ti/Lu–O atoms,as demonstrated by combined experimental and theoretical analyses,including high-energy synchrotron X-ray diffraction,Raman spectroscopy,and density functional theory calculations.This study introduces a novel example of NTE over a broad temperature range,highlighting its potential as a high-performance thermal expansion compensator.Additionally,it presents an effective method for incorporating rare-earth elements to achieve NTE in PbTiO_(3)-based perovskites across a wide temperature range.展开更多
BACKGROUND Blonanserin,a novel antipsychotic,has demonstrated efficacy in treating both positive and negative symptoms.However,limited research exists on its dose-dependent effectiveness and safety in patients with an...BACKGROUND Blonanserin,a novel antipsychotic,has demonstrated efficacy in treating both positive and negative symptoms.However,limited research exists on its dose-dependent effectiveness and safety in patients with and without prominent nega-tive symptoms(PNS).AIM To evaluate the effectiveness and safety of blonanserin monotherapy for first-episode schizophrenia in real-world clinical settings and to explore the efficacy and safety of different doses of blonanserin for patients with PNS and without PNS.METHODS A 12-week,multicenter,prospective post-marketing surveillance was conducted.In this study,we included patients with first-episode schizophrenia who received blonanserin monotherapy.Patients were divided into those with PNS and without PNS,based on the Brief Psychiatric Rating Scale(BPRS)negative symptoms subscale scores.Additionally,patients were labeled as high-dose and low-dose was evaluated through the incidence of adverse drug reactions(ADRs).RESULTS A total of 653 patients were included in the analysis,with 613 completing the study.The BPRS total score decreased significantly from 47.94±16.31 at baseline to 26.88±9.47 at 12 weeks(P<0.001).A significant interaction of PNS×dose×time was observed for BPRS total scores(F=3.47,P=0.040)and negative symptom subscale scores(F=6.76,P=0.002).In the PNS group,the high-dose group showed greater reductions in BPRS total scores(P=0.001)and negative symptom subscale scores(P=0.003)than the low-dose group in week 12.In the without PNS group,no significant difference was observed between the high-dose and low-dose groups at any visit.Most adverse reactions were mild or moderate,with extrapyramidal symptoms(9.3%)being most common;1.5%of patients gained≥7%body weight at 12 weeks.CONCLUSION Blonanserin effectively alleviated the clinical symptoms of first-episode schizophrenia with an acceptable safety profile.High-dose blonanserin is particularly beneficial for patients with PNS in the acute phase of first-episode schizophrenia.However,due to the limitation of ADR reporting the real world,the ADR incidence observed in this study may be underestimated.展开更多
The Scholl cyclization for creating seven-membered rings is of great importance in synthesizing negatively curved polycyclic aromatic compounds.In this study,we systematically report a methodical approach for converti...The Scholl cyclization for creating seven-membered rings is of great importance in synthesizing negatively curved polycyclic aromatic compounds.In this study,we systematically report a methodical approach for converting[6]helicenes into negatively curved hexa[7]circulene using Scholl cyclization.The reaction revealed that the electron-donating substituents on the helicene terminal rings of helicenes facilitate the cyclization process while electron-withdrawing substituents would impede the cyclization.This was supported by theoretical calculations on the reaction process focusing on the arenium cation pathways.Through the application of this Scholl cyclization,a series of negatively curved hexa[7]circulene derivatives were synthesized,showing highly curved and twisted geometries.Notably,2,15-substituted derivatives exhibited high conformational stability against racemization,thereby performing circularly polarized luminescence with|glum|up to 4×10^(-3).展开更多
BACKGROUND Patients with schizophrenia may lack awareness of the importance of posttracheotomy care due to the impact of their condition,often showing resistance or misunderstanding of care measures.When coupled with ...BACKGROUND Patients with schizophrenia may lack awareness of the importance of posttracheotomy care due to the impact of their condition,often showing resistance or misunderstanding of care measures.When coupled with the impact of negative symptoms and the risk of complications after tracheotomy,patients may experience emotional fluctuations,restlessness,anxiety,and hostile behaviors,which pose significant challenges to nursing work.CASE SUMMARY We have reported the case of an 87-year-old male patient who was admitted to the hospital because of negative symptoms of schizophrenia and who underwent tracheotomy for severe pneumonia.In this study,we have summarized the nursing experience of a patient with negative symptoms of schizophrenia who underwent tracheotomy.The key nursing strategies included proper tracheotomy care,the management of psychiatric symptoms,a thorough assessment and implementation of enteral and parenteral nutrition,effective skincare,infection prevention,and comprehensive mental care.Individualized nursing skills helped stabilize the patient’s condition,followed by isolation and observation in a psychiatric hospital.CONCLUSION Effective postoperative tracheostomy care in patients with schizophrenia necessitates a tailored,multidisciplinary approach that addresses their psychiatric,physical,and emotional needs to achieve optimal clinical outcomes.展开更多
Finely tuning spectral characteristics of the epsilon-negative(ε'<0,EN) response is full of challenges when its regulatory mechanism in metacomposites is not yet clear.Herein,we have meticulously designed Cu/C...Finely tuning spectral characteristics of the epsilon-negative(ε'<0,EN) response is full of challenges when its regulatory mechanism in metacomposites is not yet clear.Herein,we have meticulously designed Cu/CaCu_(3)Ti_(4)O_(12)(Cu/CCTO) percolative metacomposites,successfully achieved both epsilon-negative and ε'-near-zero(ENZ)responses in the radio-frequency band.Before percolation,a large number of electric dipoles in the metacomposites achieved resonance characteristics near the ENZ point under the excitation of radio frequency electromagnetic fields,and as the Cu content increased,the ENZ frequency varied from 942,858,862 to 632 MHz.展开更多
OBJECTIVE:To evaluate the therapeutic effect of a selfformulated Traditional Chinese Medicine(TCM),Shugan Jieyu San(疏肝解郁散),on improvement of liver function and depression alleviation in the patients with triple n...OBJECTIVE:To evaluate the therapeutic effect of a selfformulated Traditional Chinese Medicine(TCM),Shugan Jieyu San(疏肝解郁散),on improvement of liver function and depression alleviation in the patients with triple negative breast cancer(TNBC).METHODS:A total of 60 patients diagnosed with TNBC and depression were enrolled and randomly assigned to either the control group(receiving routine tumor treatment and duloxetine)or the treatment group(receiving the TCM in addition to routine treatment).RESULTS:Both treatment and control groups showed a reduction in depressive symptoms and improved daily living abilities after treatment.However,the treatment group demonstrated significantly better outcomes compared to the control group.Furthermore,the levels of dopamine and serotonin in the serum increased in both groups after 8 weeks of treatment,while the treatment group exhibited superior results.CONCLUSIONS:This TCM showed promising results in reducing depressive symptoms and improving daily abilities in patients with TNBC and comorbid depression,which was verified by the increase in serum levels of dopamine and serotonin,suggesting the potential involvement of these neurotransmitters in the therapeutic effects of this TCM.展开更多
Adolescence is a crucial period marked by significant developmental changes,during which risk-taking behaviors can be both a normative part of development and a potential source of concern.However,prior research has f...Adolescence is a crucial period marked by significant developmental changes,during which risk-taking behaviors can be both a normative part of development and a potential source of concern.However,prior research has focused predominantly on the adverse aspects of risk-taking(i.e.,negative risk-taking),overlooked the positive counterpart(i.e.,positive risk-taking),and lacked a detailed examination of both.This study aims to elucidate the distinct characteristics and interrelationships of positive and negative risk-taking behaviors among adoles-cents and to identify the key factors that influence these behaviors.Through a comprehensive synthesis of theoretical and empirical literature,we explore the multifaceted nature of risk-taking,highlighting its complex influencing factors,including individual traits,family dynamics,peer influence,school environment,and broader community contexts.By identifying the shared and unique factors contributing to positive and negative risk-taking behaviors,we can enable adolescents to navigate this complex stage of life and design targeted interventions.Future research directions include the application of person-centered approaches,the implementation of longitudinal tracking and the interactive effects of influencing factors,among other aspects.展开更多
Triple-negative breast cancer(TNBC)represents an aggressive breast cancer subtype with poor prognosis and limited targeted treatment options.This investigation examined the anticancer potential of Caerulomycin A(Cae A...Triple-negative breast cancer(TNBC)represents an aggressive breast cancer subtype with poor prognosis and limited targeted treatment options.This investigation examined the anticancer potential of Caerulomycin A(Cae A),a natural compound derived from marine actinomycetes,against TNBC.Cae A demonstrated selective inhibition of viability and proliferation in TNBC cell lines,including 4T1,MDA-MB-231,and MDA-MB-468,through apoptosis induction.Mechanistic analyses revealed that the compound induced sustained endoplasmic reticulum(ER)stress and subsequent upregulation of C/EBP homologous protein(CHOP)expression,resulting in mitochondrial damage-mediated apoptosis.Inhibition of ER stress or CHOP expression knockdown reversed mitochondrial damage and apoptosis,highlighting the essential role of ER stress and CHOP in Cae A's anti-tumor mechanism.Both oxygen consumption rate(OCR)and extracellular acidification rate(ECAR)decreased in TNBC cells following Cae A treatment,indicating reduced mitochondrial respiratory and glycolytic capacities.This diminished energy metabolism potentially triggers ER stress and subsequent apoptosis.Furthermore,Cae A exhibited significant anti-tumor effects in the 4T1 tumor model in vivo without apparent toxicity.The compound also effectively inhibited human TNBC organoid growth.These results indicate that Cae A may serve as a potential therapeutic agent for TNBC,with its efficacy likely mediated through the disruption of glucose metabolism and the induction of ER stress-associated apoptosis.展开更多
The angular dependence of magnetoresistance(MR)in antiferromagnetic half-Heusler HoAuSn single crystals has been systematically studied.Negative MR,as large as~99%,is observed at 9 T,is not restricted to the specific ...The angular dependence of magnetoresistance(MR)in antiferromagnetic half-Heusler HoAuSn single crystals has been systematically studied.Negative MR,as large as~99%,is observed at 9 T,is not restricted to the specific configuration of applied magnetics fields and current and can persist up to 20 K,much higher than the Ne'el temperature(T_(N)≈1.9 K).Experiments and first-principles calculations suggest that the observed large negative MR is derived from a magnetic field that reconstructs the band structure and induces a Weyl point,which changes the carrier concentration.展开更多
In this paper,we introduce a qualitative analysis in order to study the monotonicity and comparability properties of a single-server retrial queueing model with Bernoulli feedback and negative customers,relative to st...In this paper,we introduce a qualitative analysis in order to study the monotonicity and comparability properties of a single-server retrial queueing model with Bernoulli feedback and negative customers,relative to stochastic orderings.Performance measures of such a system are available explicitly,while their forms are cumbersome(these formulas include integrals of Laplace transform,solutions of functional equations,etc.).Therefore,they are not exploitable from the application point of view.To overcome these difficulties,we present stochastic comparison methods in order to get qualitative estimates of these measures.In particular,we prove the monotonicity of the transition operator of the embedded Markov chain.In addition,we establish conditions for which transition operators as well as stationary probabilities,associated with two embedded Markov chains,having the same structure but with different parameters,are comparable relative to the given stochastic orderings.Further,numerical examples are carried out to illustrate the theoretical results.展开更多
This study examines the sustainability of China's pension funds in a context of negative population growth,analyzing how demographic shifts,economic fluctuations,and institutional flaws impact fund operations.The ...This study examines the sustainability of China's pension funds in a context of negative population growth,analyzing how demographic shifts,economic fluctuations,and institutional flaws impact fund operations.The research reveals that declining working-age populations and accelerating aging are causing imbalances in fund revenues and expenditures.Slower economic growth and inflation further erode contribution capacity and investment returns,while the drawbacks of the Pay-as-you-go system and provincial-level pooling models exacerbate regional risks.Pension funds face multiple challenges including revenue-expenditure imbalances,investment volatility,systemic design flaws,and population mobility-induced risks.The study proposes comprehensive optimization strategies encompassing population structure improvement,diversified funding channels,expenditure control,enhanced investment management,and institutional reforms.These measures aim to provide theoretical and practical references for addressing the sustainability challenges of pension funds under negative population growth.展开更多
文摘BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM To explore the correlations among life satisfaction,pleasure levels,and negative emotions in patients with CRF.METHODS One hundred patients with CRF who received therapy at the First Affiliated Hospital of Jinzhou Medical University between December 2022 and February 2025 were included.The Depression,Anxiety,and Stress Scale(DASS-21),Satisfaction with Life Scale(SWLS),and Temporal Experience of Pleasure Scale(TEPS)were used to evaluate negative emotions,life satisfaction,and pleasure level,respectively.Pearson’s correlation coefficient analyzed the correlation between life satisfaction,pleasure level,and negative emotions.Linear regression analysis identified the factors affecting negative emotions.RESULTS The average DASS-21 score among patients with CRF was 51.90±2.30,with subscale scores of 17.90±1.50 for depression,18.53±1.18 for anxiety,and 15.47±2.36 for stress,all significantly higher than the domestic norm(P<0.05).The average SWLS score was 22.17±4.90.Correlation analysis revealed a negative correlation between the SWLS and total DASS-21 scores(P<0.05),but not with the individual depression,anxiety,or stress dimensions.The average TEPS score was 67.80±8.34.TEPS scores were negatively correlated with the DASS-21 score and the stress dimension(P<0.05),but not with depression or anxiety.Linear regression analysis showed that TEPS scores significantly influenced DASS-21 scores(P<0.05).CONCLUSION Patients with CRF experience high levels of negative emotions,which are negatively correlated with life satisfaction and pleasure.Furthermore,pleasure level had an impact on negative emotions.
基金Projects(51278170,U1134207)supported by the National Natural Science Foundation of ChinaProject(B13024)supported by the Program of Introducing Talents of Discipline to Universities,China
文摘A simplified approach was proposed to analyze the negative skin friction calculation of special-shaped pile considering pile-soil interaction under surcharge. Based on the concentric cylinder shearing theory, considering the changes of pile shape(such as, taper angle and diameters of pile base, etc.), the load-transfer of special-shaped pile was built. The accuracy of the developed simplified approach was verified by numerical simulation model with the same condition. Then, the influence factors, such as, taper angles, the diameter of pile base, surcharge, and pile-soil interface parameters were analyzed and discussed. The results show that the developed simplified approach can calculate NSF of special-shaped pile under surcharge effectively. A limited parametric study indicates that in many practical situations special-shaped piles(such as belled wedge pile shown in this work) offer a design option that is more economical than traditional uniform cross-section piles.
基金Supported by the National Natural Science Foundation of China(No.51379142)International S&T Cooperation Program of China(No.2012DFA70490)Tianjin Municipal Natural Science Foundation(No.13JCYBJC19100 and No.13JCQNJC06900)
文摘A series of model experiments of bucket foundations concerning suction installation and negative pressure consolidation in saturated silt were carried out in a cube steel bin at Tianjin University. The experimental results show that the silt inside the bucket has been strengthened by negative pressure, and the strengthening effect decreases with the increase of the distance from the bucket. A three-dimensional numerical model of the experiments was built by means of finite element software ABAQUS with fluid-solid coupling method. The results show that the bearing capacity of the silt inside the bucket foundation increases significantly at the former stage of negative pressure consolidation, while the increasing trend slows down over time. The rotation centers of the bucket foundation and the inner soil region tend to be closer to each other based on the consolidation. The bearing capacity of the bucket foundation is improved effectively with the increase of soil strength. The effects of negative pressure consolidation on the bearing capacity of bucket foundation were also illustrated by an actual offshore wind power project case.
基金Supported by a grant from the Comprehensive Prevention and Treat-ment Project for Chronic Diseases of Shanghai Municipal Hospitals (No. SHDC12007304)
文摘Objective： The aim of this study was to evaluate the anti-tumor activity and safety of Gemcitabine （GEM） combined with Vinorelbine （NVB） in patients with advanced TNABC after chemotherapy. Methods： Thirty-seven patients with immunohistochemical proved TNABC were enrolled. The patients received 21-day cycles of NVB 25mg/m^2 i.v. with GEM 1000 mg/m^2 i.v. on days 1 and 8. Results： A total of 136 cycles were given to 37 patients（median 4 cycles, ranged 2-6 cycles）. The treatment response was evaluable in all patients. Of the 37 patients, 1 received complete remission （CR）, 8 received partial remission （PR）, 20 had stable disease （SD）, 9 had progressive disease （PD）. Overall objective response （CR＋ PR） were 24.3 %. The median time to progress （TTP） was 6 months （95% CI, 4-6 months）. The median overall survival was 24 months （95% CI, 11-37 months）. The median 1-year survival rate was （66.24±8.43）%. The median 3-year survival rate was （28.77±11.96）%. The major adverse events were grade Ⅰ-Ⅱ myelosuppression, peripheral neurologic toxicities, nausea and vomiting. Some patients had rash and hepatic dysfunction. A total of 40% of patients experienced flu-like symptoms. Alopecia and diarrhea were rare. Conclusion： The combination of GEM and NVB is an effective and well tolerated regimen for the patients with TNABC.
基金Supported by National Natural Science Foundation of China(No. 51109160)National High Technology Research and Development Program of China ("863" Program, No. 2012AA051705)International Science and Technology Cooperation Program of China (No. 2012DFA70490)
文摘Cover-bearing-type bucket foundation for offshore wind turbines has been paid more and more attention due to its low cost and great bearing capacity. In order to ensure the cover-bearing mode, the muddy soil inside the bucket foundation should be reinforced by some soil consolidation methods, such as negative pressure and electro-osmosis. Firstly, tests were conducted to obtain the reasonable current density. Meanwhile, to improve the electro-osmotic speed and effectiveness, other factors such as intermittent power and layout of electrode, were also studied in the tests. Then, the soil reinforcing tests by negative pressure combined with electro-osmosis were performed for the muddy soil consolidation inside the bucket foundation. The results showed that soil reinforcement by negative pressure was quicker and more obvious during the early phase, and electro-osmotic method can affect more range of soil by rational arrangement of electrodes. Compared with negative pressure, the electro-osmotic method was a continuous and relatively slow process of reinforcement, which was complementary to the negative pressure method. The voltage value of electro-osmosis had little effect on the muddy soil reinforcement inside the bucket foundation, and 1.5 A was chosen as the most reasonable current value for scale model testing in the electro-osmotic method.
基金supported by National Natural Science Foundation of China(Nos.51877027 and 52107140)Project funded by China Postdoctoral Science Foundation(No.2021M700662)。
文摘The mechanisms of streamer generation and propagation in double-sided pulsed surface dielectric barrier discharge(SDBD)on both sides have been analyzed and investigated by experiment and numerical simulation.The fully exposed asymmetric SDBD has two discharge processes located on the high voltage electrode(HVE)side and the ground electrode(GE)side.Discharge images of the HVE side and GE side are taken by a digital camera under continuous pulse and ICCD(Intensified Charge Coupled Device)is utilized to diagnose the generation and propagation of streamers in single pulse discharge.In order to understand the physical mechanisms of streamer evolution more deeply,we establish a 2D simulation model and analyze it from the aspects of electron density,ion density,reduced electric field and electron impact ionization source term.The results show that the primary and secondary discharges on the HVE side and the GE side of the double-sided SDBD are composed of positive streamer and negative streamer,respectively.On the HVE side,the accumulation of positive charges on the dielectric surface causes the direction of the electric field to reverse,which is the principal factor for the polarity reversal of the streamer.On the GE side,both the negative charges accumulated on the dielectric surface and the falling voltage are the key factors for the streamer polarity switch.
文摘An Electromagnetic (EM) radiation in dispersion less free space vacuum is represented by a photon, with corpuscular and wave nature. The discussions, for the past century aimed at the nature of photon inside a media having dispersion in the refraction property, other than free space. What about its nature if the space be of refractive index which is negative, is discussed in this paper. We call mechanical momentum, wave-momentum, and try to match our present theories with intriguing property of this ‘photon’ or pulse carrying EM energy packet, and more so we try to find its property energy, momentum inside a media a positive refractive media, and if the media show a negative refractive index behavior, then these queries are profound, and suitable explanations to these classical concepts of corpuscular-wave nature of photon inside these media are quest for the scientists dealing with these materials having negative index of refraction. Here some of this counterintuitive nature of corpuscular-wave nature of photon inside negative indexed material is brought out, with possible ‘new definition’ of its ‘wave-momentum’, the concept of ‘reactive energy’ inside negative indexed material, along with possible ‘new wave equation’. These definitions and expressions of ‘wave-momentum’ and ‘reactive energy’ pertaining to negative indexed material are new and discussed and derived by classical means.
基金Supported by the National High Level Hospital Clinical Research Funding,No.2023-NHLHCRF-BQ-32 and No.2023-NHLHCRFYYPPLC-ZR-13National Key Research and Development Program of China,No.2024YFE0198300Beijing Municipal Natural Science Foundation,No.7222316.
文摘BACKGROUND The number of tumor deposits(TDs)does not play a part in the current tumor node metastasis staging.Negative lymph node(NLN)status is associated with the prognosis of colorectal cancer(CRC),but its clear role in N1c stage remains to be defined.AIM To evaluate the combination of TDs and NLNs as potential prognostic indicators in N1c CRC.METHODS We retrospectively identified 107 consecutive patients who had N1c CRC radically resected at China-Japan Friendship Hospital.The combination of TDs and NLNs was calculated by the formula NLNTD=NLN/(TD+1).Cutoff values of NLNs and NLNTD were determined using the R package“survminer”.Disease-free survival(DFS),overall survival(OS)and cancer-specific survival(CSS)were determined using the Kaplan-Meier method to assess the impact of NLNTD on prognosis.Results were compared using the log-rank test.RESULTS The median follow-up time was 63.17(45.33-81.37)months for DFS,with 33.64%(36/107)of patients experiencing recurrence during follow-up.Five-year DFS was 66.0%(57.3%-76.0%).There was no significant difference in prognosis between patients with>12 and≤12 NLNs(P=0.058)for DFS.Similar results were seen according to the number of TDs.The definition of NLNTD=NLN/(TD+1)with a cutoff value of 6 divided patients into two groups with different DFS(P=0.005).Five-year DFS for patients with NLNTD>6 was 73.5%(63.6%-85.0%),compared with 50.0%(35.7%-70.0%)for those with NLNTD≤6.These two groups had different prognosis without perineural invasion(P=0.012)or lymphovascular invasion(P=0.002)even neither(P=0.053).Similar results were seen for OS and CSS.CONCLUSION NLNTD could serve as important prognostic factor for outcomes in N1c CRC patients.These patients could be stratified for prognosis through NLNTD and the high-risk should be given more attention during treatment.
基金supported by the research project within the program“Excellence Initiative-Research University”for the AGH University of Krakow(IDUB AGH,Action 21)Kun Zheng acknowledges financial support from AGH University of Krakow(No.16.16.210.476).
文摘Minimizing the thermal expansion coefficient(TEC)mismatch between the cathode and electrolyte in solid oxide fuel cells is crucial for achieving stable,durable operation and high performance.Recently,materials with negative thermal expansion(NTE)have at-tracted significant attention as effective additives for tailoring the thermomechanical properties of electrodes and enhancing cell durability.In this work,for the first time,single-phase NTE perovskite Sm_(0.85)Zn_(0.15)MnO_(3−δ)(SZM15)was successfully synthesized via the sol-gel method,eliminating the unwanted ZnO phase typically observed in materials obtained through the conventional solid-state reaction route.The sol-gel approach proved highly advantageous,offering low cost,robustness,excellent chemical homogeneity,precise compositional control,and high phase purity.After optimization of synthesis parameters,a negative TEC of approximately−6.5×10^(−6)K^(−1)was achieved in the 400-850℃range.SZM15 was then incorporated as an additive(10wt%-50wt%)into a SmBa0.5Sr0.5CoCuO_(5+δ)(SBSCCO)cathode to tune the thermomechanical properties with a La_(0.8)Sr_(0.2)Ga_(0.8)Mg_(0.2)O_(3−δ)(LSGM)electrolyte,achieving a minimal TEC mismatch of only 1%.Notably,the SBSCCO+10wt%SZM15 composite cathode exhibited the lowest polarization resistance of 0.019Ω·cm^(2)at 900℃,showing approximately 70%lower than that of the pristine cathode.Excellent long-term stability after 100 h of operation was achieved.In addition,a high peak power density of 680 mW·cm^(−2)was achieved in a Ni-YSZ(yttria-stabilized zirconia)|YSZ|Ce_(0.9)Gd_(0.1)O_(2−δ)(GDC10)|SBSCCO+10wt%SZM15 anode-supported fuel cell at 850℃,highlighting the effectiveness of incorporating NTE materials as a promising strategy for regulating the thermomechanical properties and improving the long-term stability of intermediate temperature solid oxide fuel cells(IT-SOFCs).
基金financially supported by the National Natural Science Foundation of China(Nos.22271309,12425403 and 12261131499)the National Key R&D Program of China(No.2021YFA1400300)+2 种基金financial support from the Science and Technology Development Fund from Macao SAR(No.0062/2023/ITP2)Macao Polytechnic University(No.RP/FCA-03/2023)Synchrotron X-ray powder diffraction experiments were conducted at SPring-8,approved by the Japan Synchrotron Radiation Research Institute(Nos.2024A1506,2024A1695 and 2024B1807)
文摘Negative thermal expansion(NTE)is a notable physical property where a material’s volume decreases instead of increasing when heated.The identification of NTE materials is crucial for thermal expansion control engineering.Most NTE materials exhibit NTE only within a narrow temperature range,restricting their applications.Achieving NTE across a broad temperature range remains a significant challenge.This study developed a novel PbTiO_(3)-based system,(1-x)PbTiO_(3–x)BiLuO_(3),incorporating rare-earth elements,using a distinctive high-pressure and high-temperature synthesis technique.We achieved NTE across a broad temperature range by coupling lattice(c/a)with ferroelectric order parameters.The incorporation of BiLuO_(3)resulted in distinctive ferroelectric characteristics,including increased tetragonality,spontaneous polarization,and NTE over a broad temperature range.NTE over an extended temperature range has been achieved in 0.95PbTiO_(3)–0.05BiLuO_(3)(■=−1.7×10^(–5)K^(−1),300–840 K)and 0.90PbTiO_(3)–0.10BiLuO_(3)(■=−1.4×10^(–5)K^(−1),300–860 K),compared to pristine PbTiO_(3)(■=−1.99×10^(–5)K^(−1),300–763 K).The improved tetragonalities and broader NTE temperature range result from the strong hybridization of Pb/Bi–O and Ti/Lu–O atoms,as demonstrated by combined experimental and theoretical analyses,including high-energy synchrotron X-ray diffraction,Raman spectroscopy,and density functional theory calculations.This study introduces a novel example of NTE over a broad temperature range,highlighting its potential as a high-performance thermal expansion compensator.Additionally,it presents an effective method for incorporating rare-earth elements to achieve NTE in PbTiO_(3)-based perovskites across a wide temperature range.
文摘BACKGROUND Blonanserin,a novel antipsychotic,has demonstrated efficacy in treating both positive and negative symptoms.However,limited research exists on its dose-dependent effectiveness and safety in patients with and without prominent nega-tive symptoms(PNS).AIM To evaluate the effectiveness and safety of blonanserin monotherapy for first-episode schizophrenia in real-world clinical settings and to explore the efficacy and safety of different doses of blonanserin for patients with PNS and without PNS.METHODS A 12-week,multicenter,prospective post-marketing surveillance was conducted.In this study,we included patients with first-episode schizophrenia who received blonanserin monotherapy.Patients were divided into those with PNS and without PNS,based on the Brief Psychiatric Rating Scale(BPRS)negative symptoms subscale scores.Additionally,patients were labeled as high-dose and low-dose was evaluated through the incidence of adverse drug reactions(ADRs).RESULTS A total of 653 patients were included in the analysis,with 613 completing the study.The BPRS total score decreased significantly from 47.94±16.31 at baseline to 26.88±9.47 at 12 weeks(P<0.001).A significant interaction of PNS×dose×time was observed for BPRS total scores(F=3.47,P=0.040)and negative symptom subscale scores(F=6.76,P=0.002).In the PNS group,the high-dose group showed greater reductions in BPRS total scores(P=0.001)and negative symptom subscale scores(P=0.003)than the low-dose group in week 12.In the without PNS group,no significant difference was observed between the high-dose and low-dose groups at any visit.Most adverse reactions were mild or moderate,with extrapyramidal symptoms(9.3%)being most common;1.5%of patients gained≥7%body weight at 12 weeks.CONCLUSION Blonanserin effectively alleviated the clinical symptoms of first-episode schizophrenia with an acceptable safety profile.High-dose blonanserin is particularly beneficial for patients with PNS in the acute phase of first-episode schizophrenia.However,due to the limitation of ADR reporting the real world,the ADR incidence observed in this study may be underestimated.
基金financially supported by the Zhejiang Provincial Natural Science Foundation,China(No.LY23B040003)the Science Foundation of Zhejiang Sci-Tech University,China(No.22062026-Y)。
文摘The Scholl cyclization for creating seven-membered rings is of great importance in synthesizing negatively curved polycyclic aromatic compounds.In this study,we systematically report a methodical approach for converting[6]helicenes into negatively curved hexa[7]circulene using Scholl cyclization.The reaction revealed that the electron-donating substituents on the helicene terminal rings of helicenes facilitate the cyclization process while electron-withdrawing substituents would impede the cyclization.This was supported by theoretical calculations on the reaction process focusing on the arenium cation pathways.Through the application of this Scholl cyclization,a series of negatively curved hexa[7]circulene derivatives were synthesized,showing highly curved and twisted geometries.Notably,2,15-substituted derivatives exhibited high conformational stability against racemization,thereby performing circularly polarized luminescence with|glum|up to 4×10^(-3).
基金Supported by Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-033A。
文摘BACKGROUND Patients with schizophrenia may lack awareness of the importance of posttracheotomy care due to the impact of their condition,often showing resistance or misunderstanding of care measures.When coupled with the impact of negative symptoms and the risk of complications after tracheotomy,patients may experience emotional fluctuations,restlessness,anxiety,and hostile behaviors,which pose significant challenges to nursing work.CASE SUMMARY We have reported the case of an 87-year-old male patient who was admitted to the hospital because of negative symptoms of schizophrenia and who underwent tracheotomy for severe pneumonia.In this study,we have summarized the nursing experience of a patient with negative symptoms of schizophrenia who underwent tracheotomy.The key nursing strategies included proper tracheotomy care,the management of psychiatric symptoms,a thorough assessment and implementation of enteral and parenteral nutrition,effective skincare,infection prevention,and comprehensive mental care.Individualized nursing skills helped stabilize the patient’s condition,followed by isolation and observation in a psychiatric hospital.CONCLUSION Effective postoperative tracheostomy care in patients with schizophrenia necessitates a tailored,multidisciplinary approach that addresses their psychiatric,physical,and emotional needs to achieve optimal clinical outcomes.
基金supported by the National Natural Science Foundation of China(No.52461002)
文摘Finely tuning spectral characteristics of the epsilon-negative(ε'<0,EN) response is full of challenges when its regulatory mechanism in metacomposites is not yet clear.Herein,we have meticulously designed Cu/CaCu_(3)Ti_(4)O_(12)(Cu/CCTO) percolative metacomposites,successfully achieved both epsilon-negative and ε'-near-zero(ENZ)responses in the radio-frequency band.Before percolation,a large number of electric dipoles in the metacomposites achieved resonance characteristics near the ENZ point under the excitation of radio frequency electromagnetic fields,and as the Cu content increased,the ENZ frequency varied from 942,858,862 to 632 MHz.
文摘OBJECTIVE:To evaluate the therapeutic effect of a selfformulated Traditional Chinese Medicine(TCM),Shugan Jieyu San(疏肝解郁散),on improvement of liver function and depression alleviation in the patients with triple negative breast cancer(TNBC).METHODS:A total of 60 patients diagnosed with TNBC and depression were enrolled and randomly assigned to either the control group(receiving routine tumor treatment and duloxetine)or the treatment group(receiving the TCM in addition to routine treatment).RESULTS:Both treatment and control groups showed a reduction in depressive symptoms and improved daily living abilities after treatment.However,the treatment group demonstrated significantly better outcomes compared to the control group.Furthermore,the levels of dopamine and serotonin in the serum increased in both groups after 8 weeks of treatment,while the treatment group exhibited superior results.CONCLUSIONS:This TCM showed promising results in reducing depressive symptoms and improving daily abilities in patients with TNBC and comorbid depression,which was verified by the increase in serum levels of dopamine and serotonin,suggesting the potential involvement of these neurotransmitters in the therapeutic effects of this TCM.
基金Soft Science Special Project of Gansu Basic Research Plan,No.25JRZA072Youth Project of Philosophy and Social Science Foundation of Gansu Province,No.2024QN015+1 种基金General Project of Philosophy and Social Science Foundation of Gansu Province,No.2024YB049Lanzhou Philosophy and Social Science Planning Project,No.24-B13.
文摘Adolescence is a crucial period marked by significant developmental changes,during which risk-taking behaviors can be both a normative part of development and a potential source of concern.However,prior research has focused predominantly on the adverse aspects of risk-taking(i.e.,negative risk-taking),overlooked the positive counterpart(i.e.,positive risk-taking),and lacked a detailed examination of both.This study aims to elucidate the distinct characteristics and interrelationships of positive and negative risk-taking behaviors among adoles-cents and to identify the key factors that influence these behaviors.Through a comprehensive synthesis of theoretical and empirical literature,we explore the multifaceted nature of risk-taking,highlighting its complex influencing factors,including individual traits,family dynamics,peer influence,school environment,and broader community contexts.By identifying the shared and unique factors contributing to positive and negative risk-taking behaviors,we can enable adolescents to navigate this complex stage of life and design targeted interventions.Future research directions include the application of person-centered approaches,the implementation of longitudinal tracking and the interactive effects of influencing factors,among other aspects.
基金supported by the Science and Education Integration Project by the Innovation and Entrepreneurship Office of Nanjing University(No.0214-1480608207)Jiangsu Provincial Research Hospital(No.YJXYY202204)。
文摘Triple-negative breast cancer(TNBC)represents an aggressive breast cancer subtype with poor prognosis and limited targeted treatment options.This investigation examined the anticancer potential of Caerulomycin A(Cae A),a natural compound derived from marine actinomycetes,against TNBC.Cae A demonstrated selective inhibition of viability and proliferation in TNBC cell lines,including 4T1,MDA-MB-231,and MDA-MB-468,through apoptosis induction.Mechanistic analyses revealed that the compound induced sustained endoplasmic reticulum(ER)stress and subsequent upregulation of C/EBP homologous protein(CHOP)expression,resulting in mitochondrial damage-mediated apoptosis.Inhibition of ER stress or CHOP expression knockdown reversed mitochondrial damage and apoptosis,highlighting the essential role of ER stress and CHOP in Cae A's anti-tumor mechanism.Both oxygen consumption rate(OCR)and extracellular acidification rate(ECAR)decreased in TNBC cells following Cae A treatment,indicating reduced mitochondrial respiratory and glycolytic capacities.This diminished energy metabolism potentially triggers ER stress and subsequent apoptosis.Furthermore,Cae A exhibited significant anti-tumor effects in the 4T1 tumor model in vivo without apparent toxicity.The compound also effectively inhibited human TNBC organoid growth.These results indicate that Cae A may serve as a potential therapeutic agent for TNBC,with its efficacy likely mediated through the disruption of glucose metabolism and the induction of ER stress-associated apoptosis.
基金financially supported by the National Key R&D Program of China(No.2022YFA1402600)the National Natural Science Foundation of China(Nos.12304150 and 52161135108)support by the National Science Centre(Poland)(No.2021/40/Q/ST5/00066)。
文摘The angular dependence of magnetoresistance(MR)in antiferromagnetic half-Heusler HoAuSn single crystals has been systematically studied.Negative MR,as large as~99%,is observed at 9 T,is not restricted to the specific configuration of applied magnetics fields and current and can persist up to 20 K,much higher than the Ne'el temperature(T_(N)≈1.9 K).Experiments and first-principles calculations suggest that the observed large negative MR is derived from a magnetic field that reconstructs the band structure and induces a Weyl point,which changes the carrier concentration.
文摘In this paper,we introduce a qualitative analysis in order to study the monotonicity and comparability properties of a single-server retrial queueing model with Bernoulli feedback and negative customers,relative to stochastic orderings.Performance measures of such a system are available explicitly,while their forms are cumbersome(these formulas include integrals of Laplace transform,solutions of functional equations,etc.).Therefore,they are not exploitable from the application point of view.To overcome these difficulties,we present stochastic comparison methods in order to get qualitative estimates of these measures.In particular,we prove the monotonicity of the transition operator of the embedded Markov chain.In addition,we establish conditions for which transition operators as well as stationary probabilities,associated with two embedded Markov chains,having the same structure but with different parameters,are comparable relative to the given stochastic orderings.Further,numerical examples are carried out to illustrate the theoretical results.
文摘This study examines the sustainability of China's pension funds in a context of negative population growth,analyzing how demographic shifts,economic fluctuations,and institutional flaws impact fund operations.The research reveals that declining working-age populations and accelerating aging are causing imbalances in fund revenues and expenditures.Slower economic growth and inflation further erode contribution capacity and investment returns,while the drawbacks of the Pay-as-you-go system and provincial-level pooling models exacerbate regional risks.Pension funds face multiple challenges including revenue-expenditure imbalances,investment volatility,systemic design flaws,and population mobility-induced risks.The study proposes comprehensive optimization strategies encompassing population structure improvement,diversified funding channels,expenditure control,enhanced investment management,and institutional reforms.These measures aim to provide theoretical and practical references for addressing the sustainability challenges of pension funds under negative population growth.
