AIMTo noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI)and glucose metabolism measured by<sup>18</sup>F-labeled fluorodeoxyglucose positron em...AIMTo noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI)and glucose metabolism measured by<sup>18</sup>F-labeled fluorodeoxyglucose positron emission tomography/computed tomography(<sup>18</sup>F-FDG-PET/CT)during radiation therapy(RT)for human papillomavirus negative(HPV-)head and neck squamous cell carcinoma(HNSCC).METHODSIn this prospective study,6 HPV-HNSCC patients underwent a total of 34 multimodality imaging examinations DW-MRI at 1.5 T Philips MRI scanner[(n=24)pre-,during-(2-3 wk),and post-treatment(Tx),and<sup>18</sup>F-FDG PET/CT pre-and post-Tx(n=10)].All patients received RT.Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC)and the mean of standardized uptake value(SUV)was measured from<sup>18</sup>F-FDG PET uptake.All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTSThere was a strong negative correlation between the mean of pretreatment ADC(ρ=-0.67,P=0.01)and the pretreatment<sup>18</sup>F-FDG PET SUV.The percentage(%)change in delta(∆)ADC for primary tumors and neck nodal metastases between pre-and Wk<sub>2-3</sub>Tx were as follows:75.4%and 61.6%,respectively,for the patient with no evidence of disease,27.5%and 32.7%,respectively,for those patients who were alive with disease,and 26.9%and 7.31%,respectively,for those who were dead with disease.CONCLUSIONThese results are preliminary in nature and are indicative,and not definitive,trends rendered by the imaging metrics due to the small sample size of HPV-HNSCC patients in a Meixoeiro Hospital of Vigo Experience.展开更多
基金National Health Institute of Spain:ISCIII Grant PI11/02035 and DTS14/00188BIOCAPS project(FP7/REGPOT-2012-2013.1),No.316265+1 种基金MSKCC internal IMRAS grantin part through the NIH/NCI Cancer Center,No.P30 CA008748
文摘AIMTo noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI)and glucose metabolism measured by<sup>18</sup>F-labeled fluorodeoxyglucose positron emission tomography/computed tomography(<sup>18</sup>F-FDG-PET/CT)during radiation therapy(RT)for human papillomavirus negative(HPV-)head and neck squamous cell carcinoma(HNSCC).METHODSIn this prospective study,6 HPV-HNSCC patients underwent a total of 34 multimodality imaging examinations DW-MRI at 1.5 T Philips MRI scanner[(n=24)pre-,during-(2-3 wk),and post-treatment(Tx),and<sup>18</sup>F-FDG PET/CT pre-and post-Tx(n=10)].All patients received RT.Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC)and the mean of standardized uptake value(SUV)was measured from<sup>18</sup>F-FDG PET uptake.All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTSThere was a strong negative correlation between the mean of pretreatment ADC(ρ=-0.67,P=0.01)and the pretreatment<sup>18</sup>F-FDG PET SUV.The percentage(%)change in delta(∆)ADC for primary tumors and neck nodal metastases between pre-and Wk<sub>2-3</sub>Tx were as follows:75.4%and 61.6%,respectively,for the patient with no evidence of disease,27.5%and 32.7%,respectively,for those patients who were alive with disease,and 26.9%and 7.31%,respectively,for those who were dead with disease.CONCLUSIONThese results are preliminary in nature and are indicative,and not definitive,trends rendered by the imaging metrics due to the small sample size of HPV-HNSCC patients in a Meixoeiro Hospital of Vigo Experience.
