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Important clinical features of atypical antipsychotics in acute bipolar depression that inform routine clinical care: a review of pivotal studies with number needed to treat 被引量:1
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作者 Keming Gao Chengmei Yuan +4 位作者 Renrong Wu Jun Chen Zuowei Wang Yiru Fang Joseph R.Calabrese 《Neuroscience Bulletin》 SCIE CAS CSCD 2015年第5期572-588,共17页
English-language literature cited in MEDLINE from January,1980 to October 30,2014 was searched by using terms of antipsychotic,generic and brand names of atypical antipsychotics, "bipolar depression/bipolar disorder... English-language literature cited in MEDLINE from January,1980 to October 30,2014 was searched by using terms of antipsychotic,generic and brand names of atypical antipsychotics, "bipolar depression/bipolar disorder", "placebo",and "trial".The parameters of response(≥50%improvement on MADRS,Montgomery-Asberg Depression Rating Scale total score),remission(either ≤12 or 8 on MADRS total score at endpoint),discontinuation due to adverse events(DAEs),somnolence,≥7%weight gain,overall extrapyramidal side-effects(EPSs),and akathisia,were extracted from originally published primary outcome papers.The number needed to treat to benefit(NNT) for response and remission or harm(NNH) for DAEs or other side effects relative to placebo were estimated and presented with the estimate and 95%confidence interval.Olanzapine monotherapy,olanzapine-fluoxetine combination(OFC),quetiapine-IR monotherapy,quetiapine-XR monotherapy,lurasidone monotherapy,and lurasidone adjunctive therapy were superior to placebo with NNTs for responses of 11-12,4,7-8,4,4-5,and 7,and NNTs for remission of 11-12,4,5-11,7,6-7,and 6,respectively.There was no significant difference between OFC and lamotrigine,and between aripiprazole or ziprasidone and placebo in response and remission.Olanzapine monotherapy,quetiapine-IR,quetiapine-XR,aripiprazole,and ziprasidone 120-160 mg/day had significantly increased risk for DAEs with NNHs of 24,8-14,9,12,and 10,respectively.For somnolence,quetiapine-XR had the smallest NNH of 4.For ≥7%weight gain,olanzapine monotherapy and OFC had the smallest NNHs with both of 5.For akathisia,aripiprazole had the smallest NNH of 5.These findings suggest that among the FDA-approved agents including OFC,quetiapine-IR and-XR,lurasidone monotherapy and adjunctive therapy to a mood stabilizer,the differences in the NNTs for response and remission are small,but the differences in NNHs for DAEs and common side-effects are large.Therefore,the selection of an FDA-approved atypical antipsychotic for bipolar depression should be based upon safety and tolerability. 展开更多
关键词 bipolar depression atypical antipsychotic number needed to treat efficacy tolerability weight gain somnolence extrapyramidal side-effects akathisia
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New Approaches Needed for Poverty Alleviation Efforts in 21^(st) Century
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《China Population Today》 2000年第Z2期19-20,共2页
关键词 In New Approaches needed for Poverty Alleviation Efforts in 21 CENTURY
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A Needed Reform
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《ChinAfrica》 2013年第9期44-44,共1页
In recent years,interest rate liberalization has become a hot topic amidst China's financial reforms.The People's Bank of China(PBC) expanded the floating range of deposit and loan interest rates in 2012,and elimi... In recent years,interest rate liberalization has become a hot topic amidst China's financial reforms.The People's Bank of China(PBC) expanded the floating range of deposit and loan interest rates in 2012,and eliminated the floor on lending rates on July 20,2013,a clear indication of the government's intention to liberalize interest rates in future financial reforms.Jia Kang,Director of the Research Institute of Fiscal Science under the Ministry of Finance,and Meng Yan,an associate researcher at the Research Institute of Fiscal Science,believe that the interest rate liberalization is vital to China's financial reforms. 展开更多
关键词 In AS A needed Reform PBC
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Wisdom Needed on 2009
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作者 Shang Lin’aiyi 《China Textile》 2009年第1期34-37,共4页
Ten years ago, the noted Chinese economist Wu Jinglian said that to enter the Chinese stock market, one needed lots of wisdom. Today, we could say the same about handling the whole of China's economy. A new year h... Ten years ago, the noted Chinese economist Wu Jinglian said that to enter the Chinese stock market, one needed lots of wisdom. Today, we could say the same about handling the whole of China's economy. A new year has only just begun, many government officials, scholars and market observers are pushing out analysis and projections. The discreet, optimism and expectations shown by those experts pose a flying new start of the new year, which is obviously of more far-reaching significance for the incoming year… 展开更多
关键词 Wisdom needed on 2009
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Deep Pockets Needed
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作者 Trevor Maisiri 《ChinAfrica》 2011年第10期24-25,共2页
Angola’s capital Luanda ranked as the world’s most expensive city for expatriates THE nation of Angola occupies a distinctive place in the narrative of African countries’ transition from both colonialism and civil ... Angola’s capital Luanda ranked as the world’s most expensive city for expatriates THE nation of Angola occupies a distinctive place in the narrative of African countries’ transition from both colonialism and civil war toward national development.Having been occupied by the Portuguese from around 1482,the country got independence in 1975;however,a civil war that pitted the National Union for the Total Independence of Angola(UNITA) led by Jonas Savimbi and the People’s Movement for the Liberation of Angola(MPLA) led by Jose Edu- ardo dos Santos persisted until 2002. 展开更多
关键词 Deep Pockets needed
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More Power Needed
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作者 Francois Essomba 《ChinAfrica》 2011年第7期27-27,共1页
Central African countries work toward increasing electricity production THE countries of the Central African sub-region are committed to working together to facilitate the emergence of a regional market in energy by 2... Central African countries work toward increasing electricity production THE countries of the Central African sub-region are committed to working together to facilitate the emergence of a regional market in energy by 2020. This commitment was taken during an international forum that took place in Yaounde,Cameroon in April 2011.Attended by almost 1,500 Central African and international delegates. 展开更多
关键词 More Power needed
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CULTURAL KNOWLEDGE IS NEEDED IN SECOND(FOREIGN)LANGUAGE TEACHING AND LEARNING IN CHINA 被引量:56
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作者 Yan Guoquan Guangxi Baise Agricutural School 《Chinese Journal of Applied Linguistics》 1999年第2期54-56,共3页
This article tackles the problem of cultural interferences in foreign language teaching andlearning for Chinese learners of English.It also calls for more attention from teachers,textbook com-pilers and students thems... This article tackles the problem of cultural interferences in foreign language teaching andlearning for Chinese learners of English.It also calls for more attention from teachers,textbook com-pilers and students themselves. 展开更多
关键词 FOREIGN)LANGUAGE TEACHING AND LEARNING IN CHINA CULTURAL KNOWLEDGE IS needed IN SECOND very
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GLOBAL ACTION NEEDED TO COMBAT DIABETES, SAYS WHO DIRECTOR-GENERAL 15th International Diabetes Federation Congress in Japan
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《Chinese Medical Journal》 SCIE CAS CSCD 1995年第2期7-7,共1页
Action on a broad front is necessary to tackle the growing global burden of diabetes and make it a preventable
关键词 ACTION SAYS WHO DIRECTOR-GENERAL 15th International Diabetes Federation Congress in Japan WHO GLOBAL ACTION needed TO COMBAT DIABETES
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Huge Investment Needed
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《Beijing Review》 2006年第39期14-15,共2页
China needs a massive investment to maintain its rampant economic boom-at least a 20 percent annual growth rate, according to Fan Gang, Deputy Director of the National Economic Research Institute and a member of the c... China needs a massive investment to maintain its rampant economic boom-at least a 20 percent annual growth rate, according to Fan Gang, Deputy Director of the National Economic Research Institute and a member of the central bank's Monetary Policy Committee. 展开更多
关键词 In Huge Investment needed GDP
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More Work Needed
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作者 LU LING 《Beijing Review》 2006年第28期24-25,共2页
On World Environment Day, June 5, the Chinese Government issued a white paper, entitled "Environmental Protection in China." This is the country's second white paper on the issue, coming 10 years after t... On World Environment Day, June 5, the Chinese Government issued a white paper, entitled "Environmental Protection in China." This is the country's second white paper on the issue, coming 10 years after the first one. The new document, which systematically elaborates on China's efforts to control pollution, concludes that the environmental situation, in contrast with the fast 展开更多
关键词 PRO GDP More Work needed
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Delicate Readjustment Needed
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《Beijing Review》 2006年第41期17-,共1页
After nearly three decades of rapid development, the Chinese economy is suffering some structural setbacks. In response, Yu Yongding, Director of the Institute of World Economics and Politics of the Chinese Academy of... After nearly three decades of rapid development, the Chinese economy is suffering some structural setbacks. In response, Yu Yongding, Director of the Institute of World Economics and Politics of the Chinese Academy of Social Sciences, gives suggestions to adjustments of the country’s development strategy. 展开更多
关键词 Delicate Readjustment needed FDI
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Joint Endeavor Needed
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作者 DING YING 《Beijing Review》 2009年第39期34-35,共2页
Chinese President Hu jintao for more efforts by both developed and developing countries to cope with global climate
关键词 Joint Endeavor needed
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A Much Needed Raise
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作者 HU YUE 《Beijing Review》 2010年第7期30-30,共1页
Chinese provinces and municipalities unveil plans to raise their minimum wage standards In a move to bridge the growing rich-poorgap, provinces across China are
关键词 A Much needed Raise
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New Power Sources Needed for Soldier of the Future
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作者 徐妍 《科技英语学习》 2007年第9期11-13,共3页
未来军队现代化的目标是什么?而未来的士兵又需要哪些新式装备呢?现代高科技给单兵作战者提供了更强大的威力,这当然不光是在武器方面,而更重要的是能源供应与补充,因为不论什么先进仪器都需要持续稳定的能源作保障。除了下文中提到的... 未来军队现代化的目标是什么?而未来的士兵又需要哪些新式装备呢?现代高科技给单兵作战者提供了更强大的威力,这当然不光是在武器方面,而更重要的是能源供应与补充,因为不论什么先进仪器都需要持续稳定的能源作保障。除了下文中提到的新型装备外,读者还能想到哪些呢? 展开更多
关键词 New Power Sources needed for Soldier of the Future
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Analysis of Daily Life,Spiritual Comfort,and Fall Safety Care Needs of Elderly People in Urban and Rural Areas
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作者 Fang Zheng Xiaojing Tang Xinyue Zhang 《Journal of Clinical and Nursing Research》 2025年第1期157-163,共7页
Objective: To examine the daily life care, spiritual comfort, and fall safety care needs of the elderly in urban and rural areas of Tangshan, along with their influencing factors. Methods: From August 2022 to April 20... Objective: To examine the daily life care, spiritual comfort, and fall safety care needs of the elderly in urban and rural areas of Tangshan, along with their influencing factors. Methods: From August 2022 to April 2023, an investigation was conducted among urban and rural elderly individuals aged over 75 years in Tangshan City using the Activities of Daily Living Scale, the Revised Community Elderly Fall Risk Assessment Tool, and the Loneliness Scale. Results: The study included 750 urban and 740 rural elderly individuals aged over 75 years. Matrix analysis revealed a significant proportion of fall safety care needs across various daily life and spiritual care requirements. Multiple factor analysis indicated that advanced age, lower education levels, a greater number of chronic diseases, and lower levels of family and social support were associated with higher care demands among the elderly in both urban and rural areas. These differences were statistically significant (P < 0.05). Conclusion: The elderly in urban and rural areas demonstrate a high demand for fall safety care. Particular attention should be given to individuals with lower education levels, those who are widowed, those with multiple chronic diseases, and those with low levels of family and social support to better meet the diverse care needs of this population. 展开更多
关键词 Elderly people Daily life care needs Spiritual comfort needs Fall safety care needs Matrix analysis
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A Qualitative Study on the Self-Management Experiences and Outpatient Nursing Needs of Intestinal Stoma Patients During the Post- Discharge Transition Period
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作者 Yueqing Ren Ye Li +2 位作者 Baoling Zhou Yuqing Wang Yunfen Sun 《Journal of Clinical and Nursing Research》 2025年第11期165-171,共7页
Objective:To explore the self-management experiences and outpatient nursing needs of intestinal stoma patients during the post-discharge transition period,in order to provide a basis for scientific decision-making in ... Objective:To explore the self-management experiences and outpatient nursing needs of intestinal stoma patients during the post-discharge transition period,in order to provide a basis for scientific decision-making in patient self-care and improvements in specialized stoma outpatient services.Methods:Using purposive sampling,13 colorectal cancer patients in the post-discharge transition period who had undergone intestinal stoma surgery were selected from a tertiary hospital in Shandong Province between November 2024 and March 2025.Semi-structured interviews were conducted,and data were analyzed using Colaizzi’s seven-step method to extract themes.Results:Three core themes were identified:challenges in self-management during the transition period,outpatient nursing needs during the transition period,and gaps in doctor-patient information continuity.Conclusion:Future efforts should focus on high-risk groups of stoma patients during the transition period by building intelligent and systematic outpatient guidance and support systems to improve their quality of life. 展开更多
关键词 Transition period ENTEROSTOMY Self-management experience Outpatient care needs Qualitative research
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Analysis of the current status and influencing factors of basic psychological needs of community residents in Yanbian
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作者 Shu-Han Liu Yin-Ji Jin 《Nursing Communications》 2025年第13期1-7,共7页
Background:Despite self-determination theory’s prominence,few studies examine BPN in China’s ethnic frontier regions.Therefore,this study investigates and analyzes the current situation of community residents with d... Background:Despite self-determination theory’s prominence,few studies examine BPN in China’s ethnic frontier regions.Therefore,this study investigates and analyzes the current situation of community residents with different demographic characteristics in Yanbian in the three basic psychological needs of competency needs,autonomy needs and attribution needs,so as to provide reference for the construction of community service in Yanbian area.Methods:A survey was conducted among 234 residents in four communities in Yanbian from September to October 2024.The equal probability random sampling method was used to collect data by using a general information questionnaire and basic psychological demand scale,and SPSS 28.0 was used for analysis.Through single factor analysis,Pearson correlation analysis and multiple linear regression analysis,the influencing factors and correlation of basic psychological needs of community residents in Yanbian area were discussed.Results:The basic psychological needs of residents were above the middle level;there is a significant positive correlation between economic status and the three dimensions of basic psychological needs(P<0.001).There is a significant positive correlation between the three dimensions of competence demand(β=2.028,P<0.001),autonomy demand(β=2.022,P<0.001),and attribution demand(β=2.693,P<0.001).Conclusion:The satisfaction degree of basic psychological needs of community residents in Yanbian is significantly affected by economic situation,which urges nurses to advocate for economic empowerment programs in community health and provides an empirical basis for the construction of a psychological service system in this area.At the same time,it is proposed that the region can respond by improving social support and improving employment results. 展开更多
关键词 basic psychological needs community residents self-determination theory PSYCHOLOGY
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Elderly care needs and factors influencing negative emotions among first-generation only child parents in a Chinese city
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作者 Rui Dong Xiu-Xia Wang Ling-Juan Zhang 《World Journal of Psychiatry》 2025年第5期155-163,共9页
BACKGROUND China has recently encountered severe challenges associated with population aging.Parents of first-generation only children face significant challenges regarding elderly care needs and the associated negati... BACKGROUND China has recently encountered severe challenges associated with population aging.Parents of first-generation only children face significant challenges regarding elderly care needs and the associated negative emotions.AIM To analyze the elderly care needs of first-generation only child parents in China and identify factors that influence negative emotions.METHODS This study used a cross-sectional design.Convenience sampling was used to select 1580 elderly individuals who met the inclusion criteria in a Chinese city between June and September 2022.A questionnaire was administered to collect general information about participants.Depression and anxiety were assessed using the patient health questionnaire-9 and generalized anxiety disorder-7 scale,respectively.A logistic regression analysis was performed to evaluate the relevant correlations.RESULTS Among 1580 first-generation only child parents,1120(70.89%)preferred family based care,324(20.51%)opted for community care,and 136(8.61%)chose institutional care,with 460(29.11%)reporting negative emotions.Significant differences in the distribution of negative emotions among only child parents were observed based on age,marital status,living conditions,disability,type of chronic disease,frailty status,and family support(P<0.05).The regression analysis indicated that disability,type of chronic disease,living environment,frailty status,and level of family support were independent risk factors for negative emotions among parents with only children(P<0.05).CONCLUSION Elderly care for parents of only children is primarily family-based.Independent risk factors for negative emotions in this group include disability,chronic disease type,and living environment. 展开更多
关键词 AGING First generation Only child Elderly care needs Negative emotions Influencing factors
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Research progress on information needs of perinatal women
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作者 Jia-Wei Du Li-Hua Jin 《Nursing Communications》 2025年第2期1-7,共7页
Describe the content and current situation of maternal information needs and support,providing a basis for building maternal information needs assessment tools and improving information support systems.Retrieve articl... Describe the content and current situation of maternal information needs and support,providing a basis for building maternal information needs assessment tools and improving information support systems.Retrieve articles related to the topic from domestic and foreign databases,and ultimately include 54 articles.Summarize from the aspects of information demand content,influencing factors,evaluation tools,and information support channels.We found that the information needs of pregnant women are rich in content,but the existing information support content is limited and the form is single.There is an urgent need to establish scientific and effective information needs assessment tools,as well as diverse information support systems. 展开更多
关键词 perinatal period information needs REVIEW
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