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Important clinical features of atypical antipsychotics in acute bipolar depression that inform routine clinical care: a review of pivotal studies with number needed to treat 被引量:1
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作者 Keming Gao Chengmei Yuan +4 位作者 Renrong Wu Jun Chen Zuowei Wang Yiru Fang Joseph R.Calabrese 《Neuroscience Bulletin》 SCIE CAS CSCD 2015年第5期572-588,共17页
English-language literature cited in MEDLINE from January,1980 to October 30,2014 was searched by using terms of antipsychotic,generic and brand names of atypical antipsychotics, "bipolar depression/bipolar disorder... English-language literature cited in MEDLINE from January,1980 to October 30,2014 was searched by using terms of antipsychotic,generic and brand names of atypical antipsychotics, "bipolar depression/bipolar disorder", "placebo",and "trial".The parameters of response(≥50%improvement on MADRS,Montgomery-Asberg Depression Rating Scale total score),remission(either ≤12 or 8 on MADRS total score at endpoint),discontinuation due to adverse events(DAEs),somnolence,≥7%weight gain,overall extrapyramidal side-effects(EPSs),and akathisia,were extracted from originally published primary outcome papers.The number needed to treat to benefit(NNT) for response and remission or harm(NNH) for DAEs or other side effects relative to placebo were estimated and presented with the estimate and 95%confidence interval.Olanzapine monotherapy,olanzapine-fluoxetine combination(OFC),quetiapine-IR monotherapy,quetiapine-XR monotherapy,lurasidone monotherapy,and lurasidone adjunctive therapy were superior to placebo with NNTs for responses of 11-12,4,7-8,4,4-5,and 7,and NNTs for remission of 11-12,4,5-11,7,6-7,and 6,respectively.There was no significant difference between OFC and lamotrigine,and between aripiprazole or ziprasidone and placebo in response and remission.Olanzapine monotherapy,quetiapine-IR,quetiapine-XR,aripiprazole,and ziprasidone 120-160 mg/day had significantly increased risk for DAEs with NNHs of 24,8-14,9,12,and 10,respectively.For somnolence,quetiapine-XR had the smallest NNH of 4.For ≥7%weight gain,olanzapine monotherapy and OFC had the smallest NNHs with both of 5.For akathisia,aripiprazole had the smallest NNH of 5.These findings suggest that among the FDA-approved agents including OFC,quetiapine-IR and-XR,lurasidone monotherapy and adjunctive therapy to a mood stabilizer,the differences in the NNTs for response and remission are small,but the differences in NNHs for DAEs and common side-effects are large.Therefore,the selection of an FDA-approved atypical antipsychotic for bipolar depression should be based upon safety and tolerability. 展开更多
关键词 bipolar depression atypical antipsychotic number needed to treat efficacy tolerability weight gain somnolence extrapyramidal side-effects akathisia
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New Approaches Needed for Poverty Alleviation Efforts in 21^(st) Century
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《China Population Today》 2000年第Z2期19-20,共2页
关键词 In New Approaches needed for Poverty Alleviation Efforts in 21 CENTURY
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A Needed Reform
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《ChinAfrica》 2013年第9期44-44,共1页
In recent years,interest rate liberalization has become a hot topic amidst China's financial reforms.The People's Bank of China(PBC) expanded the floating range of deposit and loan interest rates in 2012,and elimi... In recent years,interest rate liberalization has become a hot topic amidst China's financial reforms.The People's Bank of China(PBC) expanded the floating range of deposit and loan interest rates in 2012,and eliminated the floor on lending rates on July 20,2013,a clear indication of the government's intention to liberalize interest rates in future financial reforms.Jia Kang,Director of the Research Institute of Fiscal Science under the Ministry of Finance,and Meng Yan,an associate researcher at the Research Institute of Fiscal Science,believe that the interest rate liberalization is vital to China's financial reforms. 展开更多
关键词 In AS A needed Reform PBC
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Wisdom Needed on 2009
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作者 Shang Lin’aiyi 《China Textile》 2009年第1期34-37,共4页
Ten years ago, the noted Chinese economist Wu Jinglian said that to enter the Chinese stock market, one needed lots of wisdom. Today, we could say the same about handling the whole of China's economy. A new year h... Ten years ago, the noted Chinese economist Wu Jinglian said that to enter the Chinese stock market, one needed lots of wisdom. Today, we could say the same about handling the whole of China's economy. A new year has only just begun, many government officials, scholars and market observers are pushing out analysis and projections. The discreet, optimism and expectations shown by those experts pose a flying new start of the new year, which is obviously of more far-reaching significance for the incoming year… 展开更多
关键词 Wisdom needed on 2009
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Deep Pockets Needed
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作者 Trevor Maisiri 《ChinAfrica》 2011年第10期24-25,共2页
Angola’s capital Luanda ranked as the world’s most expensive city for expatriates THE nation of Angola occupies a distinctive place in the narrative of African countries’ transition from both colonialism and civil ... Angola’s capital Luanda ranked as the world’s most expensive city for expatriates THE nation of Angola occupies a distinctive place in the narrative of African countries’ transition from both colonialism and civil war toward national development.Having been occupied by the Portuguese from around 1482,the country got independence in 1975;however,a civil war that pitted the National Union for the Total Independence of Angola(UNITA) led by Jonas Savimbi and the People’s Movement for the Liberation of Angola(MPLA) led by Jose Edu- ardo dos Santos persisted until 2002. 展开更多
关键词 Deep Pockets needed
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More Power Needed
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作者 Francois Essomba 《ChinAfrica》 2011年第7期27-27,共1页
Central African countries work toward increasing electricity production THE countries of the Central African sub-region are committed to working together to facilitate the emergence of a regional market in energy by 2... Central African countries work toward increasing electricity production THE countries of the Central African sub-region are committed to working together to facilitate the emergence of a regional market in energy by 2020. This commitment was taken during an international forum that took place in Yaounde,Cameroon in April 2011.Attended by almost 1,500 Central African and international delegates. 展开更多
关键词 More Power needed
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CULTURAL KNOWLEDGE IS NEEDED IN SECOND(FOREIGN)LANGUAGE TEACHING AND LEARNING IN CHINA 被引量:56
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作者 Yan Guoquan Guangxi Baise Agricutural School 《Chinese Journal of Applied Linguistics》 1999年第2期54-56,共3页
This article tackles the problem of cultural interferences in foreign language teaching andlearning for Chinese learners of English.It also calls for more attention from teachers,textbook com-pilers and students thems... This article tackles the problem of cultural interferences in foreign language teaching andlearning for Chinese learners of English.It also calls for more attention from teachers,textbook com-pilers and students themselves. 展开更多
关键词 FOREIGN)LANGUAGE TEACHING AND LEARNING IN CHINA CULTURAL KNOWLEDGE IS needed IN SECOND very
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GLOBAL ACTION NEEDED TO COMBAT DIABETES, SAYS WHO DIRECTOR-GENERAL 15th International Diabetes Federation Congress in Japan
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《Chinese Medical Journal》 SCIE CAS CSCD 1995年第2期7-7,共1页
Action on a broad front is necessary to tackle the growing global burden of diabetes and make it a preventable
关键词 ACTION SAYS WHO DIRECTOR-GENERAL 15th International Diabetes Federation Congress in Japan WHO GLOBAL ACTION needed TO COMBAT DIABETES
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Analysis of Daily Life,Spiritual Comfort,and Fall Safety Care Needs of Elderly People in Urban and Rural Areas
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作者 Fang Zheng Xiaojing Tang Xinyue Zhang 《Journal of Clinical and Nursing Research》 2025年第1期157-163,共7页
Objective: To examine the daily life care, spiritual comfort, and fall safety care needs of the elderly in urban and rural areas of Tangshan, along with their influencing factors. Methods: From August 2022 to April 20... Objective: To examine the daily life care, spiritual comfort, and fall safety care needs of the elderly in urban and rural areas of Tangshan, along with their influencing factors. Methods: From August 2022 to April 2023, an investigation was conducted among urban and rural elderly individuals aged over 75 years in Tangshan City using the Activities of Daily Living Scale, the Revised Community Elderly Fall Risk Assessment Tool, and the Loneliness Scale. Results: The study included 750 urban and 740 rural elderly individuals aged over 75 years. Matrix analysis revealed a significant proportion of fall safety care needs across various daily life and spiritual care requirements. Multiple factor analysis indicated that advanced age, lower education levels, a greater number of chronic diseases, and lower levels of family and social support were associated with higher care demands among the elderly in both urban and rural areas. These differences were statistically significant (P < 0.05). Conclusion: The elderly in urban and rural areas demonstrate a high demand for fall safety care. Particular attention should be given to individuals with lower education levels, those who are widowed, those with multiple chronic diseases, and those with low levels of family and social support to better meet the diverse care needs of this population. 展开更多
关键词 Elderly people Daily life care needs Spiritual comfort needs Fall safety care needs Matrix analysis
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Elderly care needs and factors influencing negative emotions among first-generation only child parents in a Chinese city
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作者 Rui Dong Xiu-Xia Wang Ling-Juan Zhang 《World Journal of Psychiatry》 2025年第5期155-163,共9页
BACKGROUND China has recently encountered severe challenges associated with population aging.Parents of first-generation only children face significant challenges regarding elderly care needs and the associated negati... BACKGROUND China has recently encountered severe challenges associated with population aging.Parents of first-generation only children face significant challenges regarding elderly care needs and the associated negative emotions.AIM To analyze the elderly care needs of first-generation only child parents in China and identify factors that influence negative emotions.METHODS This study used a cross-sectional design.Convenience sampling was used to select 1580 elderly individuals who met the inclusion criteria in a Chinese city between June and September 2022.A questionnaire was administered to collect general information about participants.Depression and anxiety were assessed using the patient health questionnaire-9 and generalized anxiety disorder-7 scale,respectively.A logistic regression analysis was performed to evaluate the relevant correlations.RESULTS Among 1580 first-generation only child parents,1120(70.89%)preferred family based care,324(20.51%)opted for community care,and 136(8.61%)chose institutional care,with 460(29.11%)reporting negative emotions.Significant differences in the distribution of negative emotions among only child parents were observed based on age,marital status,living conditions,disability,type of chronic disease,frailty status,and family support(P<0.05).The regression analysis indicated that disability,type of chronic disease,living environment,frailty status,and level of family support were independent risk factors for negative emotions among parents with only children(P<0.05).CONCLUSION Elderly care for parents of only children is primarily family-based.Independent risk factors for negative emotions in this group include disability,chronic disease type,and living environment. 展开更多
关键词 AGING First generation Only child Elderly care needs Negative emotions Influencing factors
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Research progress on information needs of perinatal women
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作者 Jia-Wei Du Li-Hua Jin 《Nursing Communications》 2025年第2期1-7,共7页
Describe the content and current situation of maternal information needs and support,providing a basis for building maternal information needs assessment tools and improving information support systems.Retrieve articl... Describe the content and current situation of maternal information needs and support,providing a basis for building maternal information needs assessment tools and improving information support systems.Retrieve articles related to the topic from domestic and foreign databases,and ultimately include 54 articles.Summarize from the aspects of information demand content,influencing factors,evaluation tools,and information support channels.We found that the information needs of pregnant women are rich in content,but the existing information support content is limited and the form is single.There is an urgent need to establish scientific and effective information needs assessment tools,as well as diverse information support systems. 展开更多
关键词 perinatal period information needs REVIEW
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Teacher support and adolescents’ personal growth initiative: The mediating role of basic psychological needs satisfaction
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作者 Xi Chen QingWang +1 位作者 Xiaoxiao Hong Wanru Lin 《Journal of Psychology in Africa》 2025年第1期37-42,共6页
This study investigated the mediating role of basic psychological needs satisfaction in relationship between teacher support and adolescents’personal growth initiative.A total of 493 adolescents(females=44.8%,mean ag... This study investigated the mediating role of basic psychological needs satisfaction in relationship between teacher support and adolescents’personal growth initiative.A total of 493 adolescents(females=44.8%,mean age=12.46,SD=0.57)completed the Teacher Support Scale,the Adolescents’Personal Growth Initiative Scale,and the Basic Psychological Needs Scale.The results,analyzed through a Mediation model analysis results indicated higher teacher support to be significantly associated with higher adolescents’personal growth initiative.Teacher support was also associated with higher basic psychological needs satisfaction.Basic psychological needs satisfaction mediated the relationship between teacher support and adolescents’personal growth initiative for higher personal growth initiative.Thus,enhancing students’perceptions of teacher support would support the student’s sense of proactive and resilient growth with basic psychological needs satisfaction. 展开更多
关键词 teacher support personal growth initiative basic psychological needs adolescents
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Smart Cities,Digital Citizenship
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作者 ZHOU LIN 《China Today》 2025年第8期28-31,共4页
Beijing defines a new model for digital-friendly cities where technology meets people’s needs and global cooperation drives inclusivity.THE 6,000-square-meter Beijing FUN Digital Complex,a vibrant pedestrian street i... Beijing defines a new model for digital-friendly cities where technology meets people’s needs and global cooperation drives inclusivity.THE 6,000-square-meter Beijing FUN Digital Complex,a vibrant pedestrian street in the historic Qianmen area of central Beijing,was bustling with visitors during the 2025 Beijing Digital Economy Experience Week,held from June 27 to July 5.Some climbed into a full-size C919 flight simulator,while others put on a domestically-made 8K VR headset to test a real-time voice-interaction model,immersing themselves in a dazzling virtual world. 展开更多
关键词 technology digital citizenship digital friendly cities smart cities peoples needs k vr headset global cooperation BEIJING
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Dynamic Route Optimization for Multi-Vehicle Systems with Diverse Needs in Road Networks Based on Preference Games
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作者 Jixiang Wang Jing Wei +2 位作者 Siqi Chen Haiyang Yu Yilong Ren 《Computers, Materials & Continua》 2025年第6期4167-4192,共26页
The real-time path optimization for heterogeneous vehicle fleets in large-scale road networks presents significant challenges due to conflicting traffic demands and imbalanced resource allocation.While existing vehicl... The real-time path optimization for heterogeneous vehicle fleets in large-scale road networks presents significant challenges due to conflicting traffic demands and imbalanced resource allocation.While existing vehicleto-infrastructure coordination frameworks partially address congestion mitigation,they often neglect priority-aware optimization and exhibit algorithmic bias toward dominant vehicle classes—critical limitations in mixed-priority scenarios involving emergency vehicles.To bridge this gap,this study proposes a preference game-theoretic coordination framework with adaptive strategy transfer protocol,explicitly balancing system-wide efficiency(measured by network throughput)with priority vehicle rights protection(quantified via time-sensitive utility functions).The approach innovatively combines(1)a multi-vehicle dynamic routing model with quantifiable preference weights,and(2)a distributed Nash equilibrium solver updated using replicator sub-dynamic models.The framework was evaluated on an urban road network containing 25 intersections with mixed priority ratios(10%–30%of vehicles with priority access demand),and the framework showed consistent benefits on four benchmarks(Social routing algorithm,Shortest path algorithm,The comprehensive path optimisation model,The emergency vehicle timing collaborative evolution path optimization method)showed consistent benefits.Results showthat across different traffic demand configurations,the proposed method reduces the average vehicle traveling time by at least 365 s,increases the road network throughput by 48.61%,and effectively balances the road loads.This approach successfully meets the diverse traffic demands of various vehicle types while optimizing road resource allocations.The proposed coordination paradigm advances theoretical foundations for fairness-aware traffic optimization while offering implementable strategies for next-generation cooperative vehicle-road systems,particularly in smart city deployments requiring mixed-priority mobility guarantees. 展开更多
关键词 Preference game vehicle road coordination large-scale road network different needs dynamic route selection
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Research Progress of Triploid Rainbow Trout Culture Technology
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作者 Sun Hongqing Ma Lin +5 位作者 You Hongzheng Luo Xin Liu Houfu Meng Muhan Sun Xueliang Bi Xiangdong 《Journal of Northeast Agricultural University(English Edition)》 2025年第1期76-85,共10页
In recent years,the quality of people's lives has gradually improved,and people pay more attention to the rationality of food nutrition.Green and healthy aquatic products,as representative of high-protein and low-... In recent years,the quality of people's lives has gradually improved,and people pay more attention to the rationality of food nutrition.Green and healthy aquatic products,as representative of high-protein and low-fat foods,are increasingly sought after by people.Triploid rainbow trout(Oncorhynchus mykiss)is rich in multiple unsaturated fatty acids and trace elements,which have rich nutrition and delicate flesh,its market demand is increasing.Triploid rainbow trout aquaculture has gradually become a characteristic economic industry in China.The triploid rainbow trout is favored by farmers because of its fast growth rate,delicious meat and large population.However,the development of triploid rainbow trout aquaculture is also restricted by many problems,such as unreasonable breeding management,high feed cost and low processing efficiency.Based on the research reports of domestic and foreign experts and scholars,this paper summarized the research progress of triploid rainbow trout,analyzed the influence of different farming models,nutritional needs,disease prevention on the triploid rainbow trout industry,and put forward suggestions for the development of triploid rainbow trout industry in order to provide scientific reference for the further development of triploid rainbow trout farming technology in China. 展开更多
关键词 triploid rainbow trout breeding mode nutritional needs disease prevention
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Basic psychological needs satisfaction mediation of the relationship between kindergarten error management climate and creative teaching
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作者 Jing Wang Ping Li 《Journal of Psychology in Africa》 2025年第2期167-172,共6页
The present study aimed to examine the association between kindergarten error management climate and creative teaching and the mediating role of basic psychological needs satisfaction.A sample of 561 Chinese kindergar... The present study aimed to examine the association between kindergarten error management climate and creative teaching and the mediating role of basic psychological needs satisfaction.A sample of 561 Chinese kindergarten teachers(females=98%,M_(age)=34.32,SD=1.25)completed self-reported questionnaires on their work error management atmosphere,basic psychological needs satisfaction,and innovative teaching.The results structural equation modelling path analysis showed that high kindergarten error management climate was associated with higher innovative teaching.Moreover,the need for competence,but not the need for relatedness accounted for kindergarten error management atmosphere related to the teachers’innovative teaching.These results clarify the role of self-perceived competencies in the relationship between kindergarten teacher error management climate and creative teaching prospects important for teacher development and supervision. 展开更多
关键词 error management climate creative teaching basic psychological needs satisfaction kindergarten teachers
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A Study of Staged Differences in the Needs of Lymphoma Patients throughout the Service under the Care Perspective
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作者 Yaru Qian Deying Hu 《Journal of Clinical and Nursing Research》 2025年第6期179-187,共9页
Based on the perspective of caring,this study constructs a whole-cycle management programme for lymphoma patients,and systematically explores the pathway of patients’health management from diagnosis to recovery by in... Based on the perspective of caring,this study constructs a whole-cycle management programme for lymphoma patients,and systematically explores the pathway of patients’health management from diagnosis to recovery by integrating literature analysis,clinical practice research,and multidisciplinary experts’consensus.Focusing on the differentiated needs of patients,the study proposes a dual-track management framework of‘precise diagnosis and treatment standard’and‘humanistic care practice’,and innovatively designs a multidisciplinary collaborative mechanism,an information-based follow-up platform,and a social support network.Through the role of‘care consultant’,the programme connects the medical team with the individual needs of patients,strengthens treatment compliance and improves the quality of life,and provides a theoretical basis and practical reference for the optimization of the whole management mode of lymphoma patients. 展开更多
关键词 Lymphoma patients Holistic management Patient needs
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The Influence of Self-Construal on Problematic Online Game Use among Chinese Adolescents:The Mediation of Basic Psychological Needs Satisfaction
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作者 Qiufeng Gao Yushu Feng +2 位作者 Changcheng Jiang Yanshan Zhang Ruixiang Gao 《International Journal of Mental Health Promotion》 2025年第9期1399-1410,共12页
Background:Fundamental internal factors like self-construal and its influence on problematic online game use(POGU)remain underexplored.Hence,this study aims to investigate the effects of independent and interdependent... Background:Fundamental internal factors like self-construal and its influence on problematic online game use(POGU)remain underexplored.Hence,this study aims to investigate the effects of independent and interdependent self-construal on POGU,with the mediation of basic psychological needs satisfaction.Methods:The study surveyed 418 Chinese junior high school students(50.24%male;Meanage=12.68,SD=0.65),assessing their levels of self-construal,basic psychological needs satisfaction,and POGU.Aparallelmediationmodelwas tested.Results:The findings showed that autonomy and competence needs satisfaction fully mediated the negative impact of independent self-construal on POGU(B=−0.052,p<0.05;B=−0.094,p<0.01,respectively),while interdependent self-construal and relatedness needs satisfaction did not have a significant effect on POGU(B=0.005,p=0.758).Additionally,while independent self-construal positively correlated with the satisfaction of all three psychological needs,interdependent self-construal only positively associated with relatedness need satisfaction(B=0.152,p<0.001).Conclusions:The study demonstrates that independent self-construal serves as a protective factor against POGU,mediated by autonomy and competence needs satisfaction,while the effects of interdependent self-construal are more complex.These insights highlight the need for tailored interventions that promote adaptive self-construal and psychological needs satisfaction among Chinese adolescents to prevent POGU. 展开更多
关键词 SELF-CONSTRUAL problematic online game use basic psychological needs satisfaction mediation model Chinese adolescents
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Screening optimal target populations with symptomatic bradyarrhythmia for pharmacotherapy:a discriminant analysis pilot study
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作者 ZHANG Wantong YI Danhui +6 位作者 LU Fang YANG Qiaoning SHI Shuai LI Qiuyan WENG Weiliang WANG Xujie ZHU Baochen 《Journal of Traditional Chinese Medicine》 2025年第1期160-166,共7页
OBJECTIVE:To screen the target population with symptomatic bradyarrhythmia for pharmacotherapy.METHODS:This study use database from clinical trial that use Yuanjiang decoction(元姜方),a traditional Chinese medicinal p... OBJECTIVE:To screen the target population with symptomatic bradyarrhythmia for pharmacotherapy.METHODS:This study use database from clinical trial that use Yuanjiang decoction(元姜方),a traditional Chinese medicinal prescription.Eligible participants were recruited and treated with Yuanjiang decoction(composed of 6 Chinese herbal medicines),200 m L twice daily.Cross-contingency analysis,logistic regression analysis,interaction analysis,discriminant analysis and 10-fold cross validation methods were used to establish discriminant model.RESULTS:This study concluded that the clinical treatment of bradyarrhythmia has a clear effect.Low minimum heart rate,high maximum heart rate are risk factors that affect the efficacy.Patients with only one comorbid disease did not significantly affect the efficacy,but patient with two or more diseases of coronary heart disease,hypertension,paroxysmal atrial fibrillation,premature ventricular contraction and premature atrial contraction at the same time did not have a good effect.Using the discriminant analysis method to establish a efficacy prediction model,y=0.07X1+0.16X2-0.65X3-1.12X4-0.71X5-0.75X6-0.91X7(X1=24 h mean heart rate,X2=minimum heart rate,X3=coronary heart disease,X4=paroxysmal atrial fibrillation,X5=premature ventricular contraction,X6=sinus block,X7=atrioventricular block).CONCLUSION:Our model based on the clinical features of patients with bradyarrhythmia.Should be useful aid for predicting pharmacotherapy response and could screen the optimal pharmacotherapy target. 展开更多
关键词 health services needs and demand BRADYCARDIA discriminant analysis drug therapy medicine Chinese traditional
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