English-language literature cited in MEDLINE from January,1980 to October 30,2014 was searched by using terms of antipsychotic,generic and brand names of atypical antipsychotics, ＂bipolar depression/bipolar disorder...English-language literature cited in MEDLINE from January,1980 to October 30,2014 was searched by using terms of antipsychotic,generic and brand names of atypical antipsychotics, ＂bipolar depression/bipolar disorder＂, ＂placebo＂,and ＂trial＂.The parameters of response（≥50%improvement on MADRS,Montgomery-Asberg Depression Rating Scale total score）,remission（either ≤12 or 8 on MADRS total score at endpoint）,discontinuation due to adverse events（DAEs）,somnolence,≥7%weight gain,overall extrapyramidal side-effects（EPSs）,and akathisia,were extracted from originally published primary outcome papers.The number needed to treat to benefit（NNT） for response and remission or harm（NNH） for DAEs or other side effects relative to placebo were estimated and presented with the estimate and 95%confidence interval.Olanzapine monotherapy,olanzapine-fluoxetine combination（OFC）,quetiapine-IR monotherapy,quetiapine-XR monotherapy,lurasidone monotherapy,and lurasidone adjunctive therapy were superior to placebo with NNTs for responses of 11-12,4,7-8,4,4-5,and 7,and NNTs for remission of 11-12,4,5-11,7,6-7,and 6,respectively.There was no significant difference between OFC and lamotrigine,and between aripiprazole or ziprasidone and placebo in response and remission.Olanzapine monotherapy,quetiapine-IR,quetiapine-XR,aripiprazole,and ziprasidone 120-160 mg/day had significantly increased risk for DAEs with NNHs of 24,8-14,9,12,and 10,respectively.For somnolence,quetiapine-XR had the smallest NNH of 4.For ≥7%weight gain,olanzapine monotherapy and OFC had the smallest NNHs with both of 5.For akathisia,aripiprazole had the smallest NNH of 5.These findings suggest that among the FDA-approved agents including OFC,quetiapine-IR and-XR,lurasidone monotherapy and adjunctive therapy to a mood stabilizer,the differences in the NNTs for response and remission are small,but the differences in NNHs for DAEs and common side-effects are large.Therefore,the selection of an FDA-approved atypical antipsychotic for bipolar depression should be based upon safety and tolerability.展开更多
In recent years,interest rate liberalization has become a hot topic amidst China＇s financial reforms.The People＇s Bank of China（PBC） expanded the floating range of deposit and loan interest rates in 2012,and elimi...In recent years,interest rate liberalization has become a hot topic amidst China＇s financial reforms.The People＇s Bank of China（PBC） expanded the floating range of deposit and loan interest rates in 2012,and eliminated the floor on lending rates on July 20,2013,a clear indication of the government＇s intention to liberalize interest rates in future financial reforms.Jia Kang,Director of the Research Institute of Fiscal Science under the Ministry of Finance,and Meng Yan,an associate researcher at the Research Institute of Fiscal Science,believe that the interest rate liberalization is vital to China＇s financial reforms.展开更多
Ten years ago, the noted Chinese economist Wu Jinglian said that to enter the Chinese stock market, one needed lots of wisdom. Today, we could say the same about handling the whole of China's economy. A new year h...Ten years ago, the noted Chinese economist Wu Jinglian said that to enter the Chinese stock market, one needed lots of wisdom. Today, we could say the same about handling the whole of China's economy. A new year has only just begun, many government officials, scholars and market observers are pushing out analysis and projections. The discreet, optimism and expectations shown by those experts pose a flying new start of the new year, which is obviously of more far-reaching significance for the incoming year…展开更多
Angola’s capital Luanda ranked as the world’s most expensive city for expatriates THE nation of Angola occupies a distinctive place in the narrative of African countries’ transition from both colonialism and civil ...Angola’s capital Luanda ranked as the world’s most expensive city for expatriates THE nation of Angola occupies a distinctive place in the narrative of African countries’ transition from both colonialism and civil war toward national development.Having been occupied by the Portuguese from around 1482,the country got independence in 1975;however,a civil war that pitted the National Union for the Total Independence of Angola(UNITA) led by Jonas Savimbi and the People’s Movement for the Liberation of Angola(MPLA) led by Jose Edu- ardo dos Santos persisted until 2002.展开更多
Central African countries work toward increasing electricity production THE countries of the Central African sub-region are committed to working together to facilitate the emergence of a regional market in energy by 2...Central African countries work toward increasing electricity production THE countries of the Central African sub-region are committed to working together to facilitate the emergence of a regional market in energy by 2020. This commitment was taken during an international forum that took place in Yaounde,Cameroon in April 2011.Attended by almost 1,500 Central African and international delegates.展开更多
This article tackles the problem of cultural interferences in foreign language teaching andlearning for Chinese learners of English.It also calls for more attention from teachers,textbook com-pilers and students thems...This article tackles the problem of cultural interferences in foreign language teaching andlearning for Chinese learners of English.It also calls for more attention from teachers,textbook com-pilers and students themselves.展开更多
Effective management of mining areas in the Luo River Basin,located in the eastern Qinling Mountains,is vital for the integrated protection and restoration needed to support the high-quality development of the Yellow ...Effective management of mining areas in the Luo River Basin,located in the eastern Qinling Mountains,is vital for the integrated protection and restoration needed to support the high-quality development of the Yellow River Basin.Using the‘cupball'model,this study analyzes the limiting factors and restoration characteristics across four mining areas and proposes a conceptual model for selecting appropriate restoration approaches.A second conceptual model is then introduced to address regional development needs,incorporating ecological conservation,safety protection,and people's wellbeing.The applicability of the integrated model selection framework is demonstrated through a case study on the south bank of the Qinglongjian River.The results indicate that:(1)The key limiting factors are similar across cases,but the degree of ecological degradation varies.(2)Mildly degraded areas are represented by a shallower and narrower‘cup',where natural recovery is the preferred approach,whereas moderately and severely degraded systems call for assisted regeneration and ecological reconstruction,respectively.(3)When the restoration models determined based on limiting factors and development needs are consistent,the model is directly applicable;if they differ,the option involving less artificial intervention is preferred;(4)Monitoring of the restored mining area on the Qinglongjian River's south bank confirms significant improvements in soil erosion control and vegetation coverage.This study provides a transferable methodology for balancing resource extraction with ecosystem conservation,offering practical insights for other ecologically vulnerable mining regions.展开更多
China needs a massive investment to maintain its rampant economic boom-at least a 20 percent annual growth rate, according to Fan Gang, Deputy Director of the National Economic Research Institute and a member of the c...China needs a massive investment to maintain its rampant economic boom-at least a 20 percent annual growth rate, according to Fan Gang, Deputy Director of the National Economic Research Institute and a member of the central bank's Monetary Policy Committee.展开更多
On World Environment Day, June 5, the Chinese Government issued a white paper, entitled "Environmental Protection in China." This is the country's second white paper on the issue, coming 10 years after t...On World Environment Day, June 5, the Chinese Government issued a white paper, entitled "Environmental Protection in China." This is the country's second white paper on the issue, coming 10 years after the first one. The new document, which systematically elaborates on China's efforts to control pollution, concludes that the environmental situation, in contrast with the fast展开更多
After nearly three decades of rapid development, the Chinese economy is suffering some structural setbacks. In response, Yu Yongding, Director of the Institute of World Economics and Politics of the Chinese Academy of...After nearly three decades of rapid development, the Chinese economy is suffering some structural setbacks. In response, Yu Yongding, Director of the Institute of World Economics and Politics of the Chinese Academy of Social Sciences, gives suggestions to adjustments of the country’s development strategy.展开更多
Chinese provinces and municipalities unveil plans to raise their minimum wage standards In a move to bridge the growing rich-poorgap, provinces across China are
BACKGROUND China has recently encountered severe challenges associated with population aging.Parents of first-generation only children face significant challenges regarding elderly care needs and the associated negati...BACKGROUND China has recently encountered severe challenges associated with population aging.Parents of first-generation only children face significant challenges regarding elderly care needs and the associated negative emotions.AIM To analyze the elderly care needs of first-generation only child parents in China and identify factors that influence negative emotions.METHODS This study used a cross-sectional design.Convenience sampling was used to select 1580 elderly individuals who met the inclusion criteria in a Chinese city between June and September 2022.A questionnaire was administered to collect general information about participants.Depression and anxiety were assessed using the patient health questionnaire-9 and generalized anxiety disorder-7 scale,respectively.A logistic regression analysis was performed to evaluate the relevant correlations.RESULTS Among 1580 first-generation only child parents,1120(70.89%)preferred family based care,324(20.51%)opted for community care,and 136(8.61%)chose institutional care,with 460(29.11%)reporting negative emotions.Significant differences in the distribution of negative emotions among only child parents were observed based on age,marital status,living conditions,disability,type of chronic disease,frailty status,and family support(P<0.05).The regression analysis indicated that disability,type of chronic disease,living environment,frailty status,and level of family support were independent risk factors for negative emotions among parents with only children(P<0.05).CONCLUSION Elderly care for parents of only children is primarily family-based.Independent risk factors for negative emotions in this group include disability,chronic disease type,and living environment.展开更多
The real-time path optimization for heterogeneous vehicle fleets in large-scale road networks presents significant challenges due to conflicting traffic demands and imbalanced resource allocation.While existing vehicl...The real-time path optimization for heterogeneous vehicle fleets in large-scale road networks presents significant challenges due to conflicting traffic demands and imbalanced resource allocation.While existing vehicleto-infrastructure coordination frameworks partially address congestion mitigation,they often neglect priority-aware optimization and exhibit algorithmic bias toward dominant vehicle classes—critical limitations in mixed-priority scenarios involving emergency vehicles.To bridge this gap,this study proposes a preference game-theoretic coordination framework with adaptive strategy transfer protocol,explicitly balancing system-wide efficiency(measured by network throughput)with priority vehicle rights protection(quantified via time-sensitive utility functions).The approach innovatively combines(1)a multi-vehicle dynamic routing model with quantifiable preference weights,and(2)a distributed Nash equilibrium solver updated using replicator sub-dynamic models.The framework was evaluated on an urban road network containing 25 intersections with mixed priority ratios(10%–30%of vehicles with priority access demand),and the framework showed consistent benefits on four benchmarks(Social routing algorithm,Shortest path algorithm,The comprehensive path optimisation model,The emergency vehicle timing collaborative evolution path optimization method)showed consistent benefits.Results showthat across different traffic demand configurations,the proposed method reduces the average vehicle traveling time by at least 365 s,increases the road network throughput by 48.61%,and effectively balances the road loads.This approach successfully meets the diverse traffic demands of various vehicle types while optimizing road resource allocations.The proposed coordination paradigm advances theoretical foundations for fairness-aware traffic optimization while offering implementable strategies for next-generation cooperative vehicle-road systems,particularly in smart city deployments requiring mixed-priority mobility guarantees.展开更多
Objective: To examine the daily life care, spiritual comfort, and fall safety care needs of the elderly in urban and rural areas of Tangshan, along with their influencing factors. Methods: From August 2022 to April 20...Objective: To examine the daily life care, spiritual comfort, and fall safety care needs of the elderly in urban and rural areas of Tangshan, along with their influencing factors. Methods: From August 2022 to April 2023, an investigation was conducted among urban and rural elderly individuals aged over 75 years in Tangshan City using the Activities of Daily Living Scale, the Revised Community Elderly Fall Risk Assessment Tool, and the Loneliness Scale. Results: The study included 750 urban and 740 rural elderly individuals aged over 75 years. Matrix analysis revealed a significant proportion of fall safety care needs across various daily life and spiritual care requirements. Multiple factor analysis indicated that advanced age, lower education levels, a greater number of chronic diseases, and lower levels of family and social support were associated with higher care demands among the elderly in both urban and rural areas. These differences were statistically significant (P < 0.05). Conclusion: The elderly in urban and rural areas demonstrate a high demand for fall safety care. Particular attention should be given to individuals with lower education levels, those who are widowed, those with multiple chronic diseases, and those with low levels of family and social support to better meet the diverse care needs of this population.展开更多
Objective:To explore the self-management experiences and outpatient nursing needs of intestinal stoma patients during the post-discharge transition period,in order to provide a basis for scientific decision-making in ...Objective:To explore the self-management experiences and outpatient nursing needs of intestinal stoma patients during the post-discharge transition period,in order to provide a basis for scientific decision-making in patient self-care and improvements in specialized stoma outpatient services.Methods:Using purposive sampling,13 colorectal cancer patients in the post-discharge transition period who had undergone intestinal stoma surgery were selected from a tertiary hospital in Shandong Province between November 2024 and March 2025.Semi-structured interviews were conducted,and data were analyzed using Colaizzi’s seven-step method to extract themes.Results:Three core themes were identified:challenges in self-management during the transition period,outpatient nursing needs during the transition period,and gaps in doctor-patient information continuity.Conclusion:Future efforts should focus on high-risk groups of stoma patients during the transition period by building intelligent and systematic outpatient guidance and support systems to improve their quality of life.展开更多
文摘English-language literature cited in MEDLINE from January,1980 to October 30,2014 was searched by using terms of antipsychotic,generic and brand names of atypical antipsychotics, ＂bipolar depression/bipolar disorder＂, ＂placebo＂,and ＂trial＂.The parameters of response（≥50%improvement on MADRS,Montgomery-Asberg Depression Rating Scale total score）,remission（either ≤12 or 8 on MADRS total score at endpoint）,discontinuation due to adverse events（DAEs）,somnolence,≥7%weight gain,overall extrapyramidal side-effects（EPSs）,and akathisia,were extracted from originally published primary outcome papers.The number needed to treat to benefit（NNT） for response and remission or harm（NNH） for DAEs or other side effects relative to placebo were estimated and presented with the estimate and 95%confidence interval.Olanzapine monotherapy,olanzapine-fluoxetine combination（OFC）,quetiapine-IR monotherapy,quetiapine-XR monotherapy,lurasidone monotherapy,and lurasidone adjunctive therapy were superior to placebo with NNTs for responses of 11-12,4,7-8,4,4-5,and 7,and NNTs for remission of 11-12,4,5-11,7,6-7,and 6,respectively.There was no significant difference between OFC and lamotrigine,and between aripiprazole or ziprasidone and placebo in response and remission.Olanzapine monotherapy,quetiapine-IR,quetiapine-XR,aripiprazole,and ziprasidone 120-160 mg/day had significantly increased risk for DAEs with NNHs of 24,8-14,9,12,and 10,respectively.For somnolence,quetiapine-XR had the smallest NNH of 4.For ≥7%weight gain,olanzapine monotherapy and OFC had the smallest NNHs with both of 5.For akathisia,aripiprazole had the smallest NNH of 5.These findings suggest that among the FDA-approved agents including OFC,quetiapine-IR and-XR,lurasidone monotherapy and adjunctive therapy to a mood stabilizer,the differences in the NNTs for response and remission are small,but the differences in NNHs for DAEs and common side-effects are large.Therefore,the selection of an FDA-approved atypical antipsychotic for bipolar depression should be based upon safety and tolerability.
文摘In recent years,interest rate liberalization has become a hot topic amidst China＇s financial reforms.The People＇s Bank of China（PBC） expanded the floating range of deposit and loan interest rates in 2012,and eliminated the floor on lending rates on July 20,2013,a clear indication of the government＇s intention to liberalize interest rates in future financial reforms.Jia Kang,Director of the Research Institute of Fiscal Science under the Ministry of Finance,and Meng Yan,an associate researcher at the Research Institute of Fiscal Science,believe that the interest rate liberalization is vital to China＇s financial reforms.
文摘Ten years ago, the noted Chinese economist Wu Jinglian said that to enter the Chinese stock market, one needed lots of wisdom. Today, we could say the same about handling the whole of China's economy. A new year has only just begun, many government officials, scholars and market observers are pushing out analysis and projections. The discreet, optimism and expectations shown by those experts pose a flying new start of the new year, which is obviously of more far-reaching significance for the incoming year…
文摘Angola’s capital Luanda ranked as the world’s most expensive city for expatriates THE nation of Angola occupies a distinctive place in the narrative of African countries’ transition from both colonialism and civil war toward national development.Having been occupied by the Portuguese from around 1482,the country got independence in 1975;however,a civil war that pitted the National Union for the Total Independence of Angola(UNITA) led by Jonas Savimbi and the People’s Movement for the Liberation of Angola(MPLA) led by Jose Edu- ardo dos Santos persisted until 2002.
文摘Central African countries work toward increasing electricity production THE countries of the Central African sub-region are committed to working together to facilitate the emergence of a regional market in energy by 2020. This commitment was taken during an international forum that took place in Yaounde,Cameroon in April 2011.Attended by almost 1,500 Central African and international delegates.
文摘This article tackles the problem of cultural interferences in foreign language teaching andlearning for Chinese learners of English.It also calls for more attention from teachers,textbook com-pilers and students themselves.
基金supported by Special major projects for research and development of Henan Provincial(Science and Technology Research Project)(No.252102321104)Humanities and Social Sciences Youth Foundation,Ministry of Education(24YJCZH410)。
文摘Effective management of mining areas in the Luo River Basin,located in the eastern Qinling Mountains,is vital for the integrated protection and restoration needed to support the high-quality development of the Yellow River Basin.Using the‘cupball'model,this study analyzes the limiting factors and restoration characteristics across four mining areas and proposes a conceptual model for selecting appropriate restoration approaches.A second conceptual model is then introduced to address regional development needs,incorporating ecological conservation,safety protection,and people's wellbeing.The applicability of the integrated model selection framework is demonstrated through a case study on the south bank of the Qinglongjian River.The results indicate that:(1)The key limiting factors are similar across cases,but the degree of ecological degradation varies.(2)Mildly degraded areas are represented by a shallower and narrower‘cup',where natural recovery is the preferred approach,whereas moderately and severely degraded systems call for assisted regeneration and ecological reconstruction,respectively.(3)When the restoration models determined based on limiting factors and development needs are consistent,the model is directly applicable;if they differ,the option involving less artificial intervention is preferred;(4)Monitoring of the restored mining area on the Qinglongjian River's south bank confirms significant improvements in soil erosion control and vegetation coverage.This study provides a transferable methodology for balancing resource extraction with ecosystem conservation,offering practical insights for other ecologically vulnerable mining regions.
文摘China needs a massive investment to maintain its rampant economic boom-at least a 20 percent annual growth rate, according to Fan Gang, Deputy Director of the National Economic Research Institute and a member of the central bank's Monetary Policy Committee.
文摘On World Environment Day, June 5, the Chinese Government issued a white paper, entitled "Environmental Protection in China." This is the country's second white paper on the issue, coming 10 years after the first one. The new document, which systematically elaborates on China's efforts to control pollution, concludes that the environmental situation, in contrast with the fast
文摘After nearly three decades of rapid development, the Chinese economy is suffering some structural setbacks. In response, Yu Yongding, Director of the Institute of World Economics and Politics of the Chinese Academy of Social Sciences, gives suggestions to adjustments of the country’s development strategy.
文摘Chinese provinces and municipalities unveil plans to raise their minimum wage standards In a move to bridge the growing rich-poorgap, provinces across China are
基金Supported by General Projects of Henan Province Universities Humanities and Social Sciences Research in 2023,No.2023-ZDJH-533.
文摘BACKGROUND China has recently encountered severe challenges associated with population aging.Parents of first-generation only children face significant challenges regarding elderly care needs and the associated negative emotions.AIM To analyze the elderly care needs of first-generation only child parents in China and identify factors that influence negative emotions.METHODS This study used a cross-sectional design.Convenience sampling was used to select 1580 elderly individuals who met the inclusion criteria in a Chinese city between June and September 2022.A questionnaire was administered to collect general information about participants.Depression and anxiety were assessed using the patient health questionnaire-9 and generalized anxiety disorder-7 scale,respectively.A logistic regression analysis was performed to evaluate the relevant correlations.RESULTS Among 1580 first-generation only child parents,1120(70.89%)preferred family based care,324(20.51%)opted for community care,and 136(8.61%)chose institutional care,with 460(29.11%)reporting negative emotions.Significant differences in the distribution of negative emotions among only child parents were observed based on age,marital status,living conditions,disability,type of chronic disease,frailty status,and family support(P<0.05).The regression analysis indicated that disability,type of chronic disease,living environment,frailty status,and level of family support were independent risk factors for negative emotions among parents with only children(P<0.05).CONCLUSION Elderly care for parents of only children is primarily family-based.Independent risk factors for negative emotions in this group include disability,chronic disease type,and living environment.
基金funded by the National Key Research and Development Program Project 2022YFB4300404.
文摘The real-time path optimization for heterogeneous vehicle fleets in large-scale road networks presents significant challenges due to conflicting traffic demands and imbalanced resource allocation.While existing vehicleto-infrastructure coordination frameworks partially address congestion mitigation,they often neglect priority-aware optimization and exhibit algorithmic bias toward dominant vehicle classes—critical limitations in mixed-priority scenarios involving emergency vehicles.To bridge this gap,this study proposes a preference game-theoretic coordination framework with adaptive strategy transfer protocol,explicitly balancing system-wide efficiency(measured by network throughput)with priority vehicle rights protection(quantified via time-sensitive utility functions).The approach innovatively combines(1)a multi-vehicle dynamic routing model with quantifiable preference weights,and(2)a distributed Nash equilibrium solver updated using replicator sub-dynamic models.The framework was evaluated on an urban road network containing 25 intersections with mixed priority ratios(10%–30%of vehicles with priority access demand),and the framework showed consistent benefits on four benchmarks(Social routing algorithm,Shortest path algorithm,The comprehensive path optimisation model,The emergency vehicle timing collaborative evolution path optimization method)showed consistent benefits.Results showthat across different traffic demand configurations,the proposed method reduces the average vehicle traveling time by at least 365 s,increases the road network throughput by 48.61%,and effectively balances the road loads.This approach successfully meets the diverse traffic demands of various vehicle types while optimizing road resource allocations.The proposed coordination paradigm advances theoretical foundations for fairness-aware traffic optimization while offering implementable strategies for next-generation cooperative vehicle-road systems,particularly in smart city deployments requiring mixed-priority mobility guarantees.
基金Model Study on the Care Effectiveness of Intergenerational Care for Disabled Elderly in Rural Areas under the Background of Silver Age(School level Project Y24-08)。
文摘Objective: To examine the daily life care, spiritual comfort, and fall safety care needs of the elderly in urban and rural areas of Tangshan, along with their influencing factors. Methods: From August 2022 to April 2023, an investigation was conducted among urban and rural elderly individuals aged over 75 years in Tangshan City using the Activities of Daily Living Scale, the Revised Community Elderly Fall Risk Assessment Tool, and the Loneliness Scale. Results: The study included 750 urban and 740 rural elderly individuals aged over 75 years. Matrix analysis revealed a significant proportion of fall safety care needs across various daily life and spiritual care requirements. Multiple factor analysis indicated that advanced age, lower education levels, a greater number of chronic diseases, and lower levels of family and social support were associated with higher care demands among the elderly in both urban and rural areas. These differences were statistically significant (P < 0.05). Conclusion: The elderly in urban and rural areas demonstrate a high demand for fall safety care. Particular attention should be given to individuals with lower education levels, those who are widowed, those with multiple chronic diseases, and those with low levels of family and social support to better meet the diverse care needs of this population.
文摘Objective:To explore the self-management experiences and outpatient nursing needs of intestinal stoma patients during the post-discharge transition period,in order to provide a basis for scientific decision-making in patient self-care and improvements in specialized stoma outpatient services.Methods:Using purposive sampling,13 colorectal cancer patients in the post-discharge transition period who had undergone intestinal stoma surgery were selected from a tertiary hospital in Shandong Province between November 2024 and March 2025.Semi-structured interviews were conducted,and data were analyzed using Colaizzi’s seven-step method to extract themes.Results:Three core themes were identified:challenges in self-management during the transition period,outpatient nursing needs during the transition period,and gaps in doctor-patient information continuity.Conclusion:Future efforts should focus on high-risk groups of stoma patients during the transition period by building intelligent and systematic outpatient guidance and support systems to improve their quality of life.
