Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th...Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.展开更多
OMG的数据发布服务(Data Delivery Service)-实时发布-订阅已经成为一个标准,它提供了一个以数据为中心的网络中间件,使得实时环境下以数据为中心的分布式应用更加高效、易于编程。作为一个比较成熟的产品,RTI的NDDS(Network Data Deliv...OMG的数据发布服务(Data Delivery Service)-实时发布-订阅已经成为一个标准,它提供了一个以数据为中心的网络中间件,使得实时环境下以数据为中心的分布式应用更加高效、易于编程。作为一个比较成熟的产品,RTI的NDDS(Network Data Delivery Service)目前已经广泛应用到了美国海、陆、空、天各个领域,并发挥了作用,证明了DDS的可靠性和稳定性。结合NDDS,研究阐述了DDS的通信机制,提出了DDS中间件的设计构想。展开更多
This paper reviewed the study of triptolide-loaded nano delivery systems(NDOS)in our group during the past.It was investigated for the preparation,characterization,pharmacology and toxicology of solid lipid nanopartic...This paper reviewed the study of triptolide-loaded nano delivery systems(NDOS)in our group during the past.It was investigated for the preparation,characterization,pharmacology and toxicology of solid lipid nanoparticles(SLN),microemulsion and polymeric nanoparticles.The results indicated that the NDS presented more powerful activity and a lower toxicity in comparison with other drug carrier.展开更多
Neutronics measurement system provides neutron fluxes and spectra at the locations of beryllium multiplier and tritium breeder during the operation of the NT-TBM （D-D and D-T phase in ITER）. This is important for st...Neutronics measurement system provides neutron fluxes and spectra at the locations of beryllium multiplier and tritium breeder during the operation of the NT-TBM （D-D and D-T phase in ITER）. This is important for studying and assessing capabilities of beryllium multiplier and tritium breeder in the China helium cooled solid breeder （CNHCSB）. A special neutron diagnostic system has been proposed that allows to measure neutron fluxes and spectra without interrupt the operation of ITER. This system includes encapsulated foil activation analysis, micro-fission chamber detectors （MFC）, and a compact neutron spectrometer using natural diamond detector （NDD）.展开更多
Alpha-tubulin proteins are recognised as key components in the process of cell division due to their role in dimerisation and polymerisation,which results in the formation of microtubules in eukaryotes;however in the ...Alpha-tubulin proteins are recognised as key components in the process of cell division due to their role in dimerisation and polymerisation,which results in the formation of microtubules in eukaryotes;however in the context of Alzheimer’s disease(AD)and other neurodegenerative diseases(NDDs),they may also play an important role,as alterations in their structure and disintegration have been observed.The present paper investigates the 189-195 region of the human tubulin α 1A protein,in the presence of essential copper(Ⅱ)and zinc(Ⅱ)ions and the toxic nickel(Ⅱ)metal ions.The aforementioned natural protein fragment contains the-(S/T)XH-amino acid motif,whose sequences were previously identified as active sites for a metal-ion-induced,sequence-specific hydrolysis process.The solution equilibrium studies(pH-potentiometry and UV-Vis and CD spectroscopy)demonstrated that the nickel(Ⅱ)and copper(Ⅱ)complexes formed under physiological pH conditions exhibit enhanced thermodynamic stability.The RP-HPLC and MS studies confirmed the irreversible behaviour of the heptapeptide due to the formation of the intermediate and final products of the hydrolytic reaction,which were induced by the nickel(Ⅱ)and copper(Ⅱ)metal ions.In the presence of nickel(Ⅱ)ions under conditions of a pH of 8.2 and a temperature of 37℃,the kinetic parameters of the reaction were determined.The half-life value for the formation of the intermediate product was found to be 3.70 hours,while that for the formation of the final product was 73.75 hours.展开更多
文摘Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.
文摘This paper reviewed the study of triptolide-loaded nano delivery systems(NDOS)in our group during the past.It was investigated for the preparation,characterization,pharmacology and toxicology of solid lipid nanoparticles(SLN),microemulsion and polymeric nanoparticles.The results indicated that the NDS presented more powerful activity and a lower toxicity in comparison with other drug carrier.
文摘Neutronics measurement system provides neutron fluxes and spectra at the locations of beryllium multiplier and tritium breeder during the operation of the NT-TBM （D-D and D-T phase in ITER）. This is important for studying and assessing capabilities of beryllium multiplier and tritium breeder in the China helium cooled solid breeder （CNHCSB）. A special neutron diagnostic system has been proposed that allows to measure neutron fluxes and spectra without interrupt the operation of ITER. This system includes encapsulated foil activation analysis, micro-fission chamber detectors （MFC）, and a compact neutron spectrometer using natural diamond detector （NDD）.
基金supported by the EKOP-KDP-2024(B.S.)University Research Scholarship Program-the cooperative doctoral program of the Ministry for Culture and Innovation from the source of the National Research,Development and Innovation FundEKOP-24-3-I-DE-431-G.Z.S.+2 种基金the Hungarian National Research,Development,and Innovation Fund(NKFIH K-134694,G.Z.S.)supported by the University of Debrecen Program for Scientific Publication,the University of Debrecen Scientific Research Bridging Fund(DETKA)the CNR/MTA bilateral agreement(Di Natale/Várnagy,2023-2025,B53C23000650005,NKM-2023/24).
文摘Alpha-tubulin proteins are recognised as key components in the process of cell division due to their role in dimerisation and polymerisation,which results in the formation of microtubules in eukaryotes;however in the context of Alzheimer’s disease(AD)and other neurodegenerative diseases(NDDs),they may also play an important role,as alterations in their structure and disintegration have been observed.The present paper investigates the 189-195 region of the human tubulin α 1A protein,in the presence of essential copper(Ⅱ)and zinc(Ⅱ)ions and the toxic nickel(Ⅱ)metal ions.The aforementioned natural protein fragment contains the-(S/T)XH-amino acid motif,whose sequences were previously identified as active sites for a metal-ion-induced,sequence-specific hydrolysis process.The solution equilibrium studies(pH-potentiometry and UV-Vis and CD spectroscopy)demonstrated that the nickel(Ⅱ)and copper(Ⅱ)complexes formed under physiological pH conditions exhibit enhanced thermodynamic stability.The RP-HPLC and MS studies confirmed the irreversible behaviour of the heptapeptide due to the formation of the intermediate and final products of the hydrolytic reaction,which were induced by the nickel(Ⅱ)and copper(Ⅱ)metal ions.In the presence of nickel(Ⅱ)ions under conditions of a pH of 8.2 and a temperature of 37℃,the kinetic parameters of the reaction were determined.The half-life value for the formation of the intermediate product was found to be 3.70 hours,while that for the formation of the final product was 73.75 hours.
