基于密集台阵的背景噪声成像是目前研究地壳结构的重要技术手段,背景噪声的噪声源演化规律的分析可加深对噪声互相关中信号的认识。对密集台阵开展聚束分析可对其所记录到的噪声类型、来源方位和季节变化等做出分析。利用2013—2016年Ch...基于密集台阵的背景噪声成像是目前研究地壳结构的重要技术手段,背景噪声的噪声源演化规律的分析可加深对噪声互相关中信号的认识。对密集台阵开展聚束分析可对其所记录到的噪声类型、来源方位和季节变化等做出分析。利用2013—2016年ChinArray二期台阵南部322个宽频带地震台的垂直分量数据,计算各台站对的噪声互相关函数(NCF),通过基于NCF的台阵聚束方法对4~30 s的噪声信号做慢度分析,得到了4~8、8~12、12~20、20~30 s 4个不同频段范围的聚束输出图像。结果表明:①在不同的周期频段,噪声信号成分并不相同:在周期较长的频段,信号主要为面波,在周期较短的频段,除了面波信号,还存在一定的体波信号;②在聚束输出图像上可以直观地观察到不同频段信号成分的变化;③在不同的周期频段,噪声信号的优势来源方向各不相同,且具有明显的季节变化,其中来源方向对应于北半球海域的噪声能量呈现出冬季较强、夏季较弱的特征,而对应于南半球海域的噪声能量变化趋势与之相反,与全球海洋活动相符。展开更多
Background:Chronic pain is defined as pain that lasts for three months or even more.Over 25%of the global population suffers from chronic pain.Tong-luo Qu-tong(TLQT)Plaster is clinically used to treat arthritis.Howeve...Background:Chronic pain is defined as pain that lasts for three months or even more.Over 25%of the global population suffers from chronic pain.Tong-luo Qu-tong(TLQT)Plaster is clinically used to treat arthritis.However,its ability to treat chronic pain remains largely unknown.Methods:In this study,we explored the molecular mechanism of TLQT plaster in relieving chronic muscle pain by combining network pharmacology and RNA-seq analysis.We also applied the Elisa and the RT-qPCR.Results:We found 447 targets in TLQT and 13,599 targets related to chronic pain disease.And 419 intersecting targets were obtained,which mainly enrich the IL-17 signaling pathway,TNF signaling pathway,and Th17 cell differentiation pathway.Further,we constructed the SD rat model of chronic pain.The results of Von Frey Hair Test showed that the relief of muscle pain TLQT treated group was twice as much as that in the model group.The hot plate test results showed that the time of lifting the foot was 1.3 times as much as that of the model group.Moreover,TLQT effectively reduced the inflammation in rat muscle.With RNA-seq analysis,230 differentially expressed genes were collected.The RT-qPCR results indicated that the mRNA expression level of NCF1,CXCL10,and ICAM1 all promoted in the model group,and then decreased significantly in the TLQT treated group.The ELISA results performed that the level of IL-1βand IL-6 in TLQT group high dose group was reduced by about 1.6-fold,and for TNF-α,it was reduced by about 2.6-fold compared with the model group.Immunohistochemistry assay showed that the expression level of CXCL10 and ICAM1 was both up-regulated in the model group and down-regulated in the TLQT group.Conclusion:TLQT plaster reduces chronic muscle pain by inhibiting the expression of NCF1,CXCL10,and ICAM1 and reducing the level of muscle tissue inflammation.展开更多
文摘基于密集台阵的背景噪声成像是目前研究地壳结构的重要技术手段,背景噪声的噪声源演化规律的分析可加深对噪声互相关中信号的认识。对密集台阵开展聚束分析可对其所记录到的噪声类型、来源方位和季节变化等做出分析。利用2013—2016年ChinArray二期台阵南部322个宽频带地震台的垂直分量数据,计算各台站对的噪声互相关函数(NCF),通过基于NCF的台阵聚束方法对4~30 s的噪声信号做慢度分析,得到了4~8、8~12、12~20、20~30 s 4个不同频段范围的聚束输出图像。结果表明:①在不同的周期频段,噪声信号成分并不相同:在周期较长的频段,信号主要为面波,在周期较短的频段,除了面波信号,还存在一定的体波信号;②在聚束输出图像上可以直观地观察到不同频段信号成分的变化;③在不同的周期频段,噪声信号的优势来源方向各不相同,且具有明显的季节变化,其中来源方向对应于北半球海域的噪声能量呈现出冬季较强、夏季较弱的特征,而对应于南半球海域的噪声能量变化趋势与之相反,与全球海洋活动相符。
文摘Background:Chronic pain is defined as pain that lasts for three months or even more.Over 25%of the global population suffers from chronic pain.Tong-luo Qu-tong(TLQT)Plaster is clinically used to treat arthritis.However,its ability to treat chronic pain remains largely unknown.Methods:In this study,we explored the molecular mechanism of TLQT plaster in relieving chronic muscle pain by combining network pharmacology and RNA-seq analysis.We also applied the Elisa and the RT-qPCR.Results:We found 447 targets in TLQT and 13,599 targets related to chronic pain disease.And 419 intersecting targets were obtained,which mainly enrich the IL-17 signaling pathway,TNF signaling pathway,and Th17 cell differentiation pathway.Further,we constructed the SD rat model of chronic pain.The results of Von Frey Hair Test showed that the relief of muscle pain TLQT treated group was twice as much as that in the model group.The hot plate test results showed that the time of lifting the foot was 1.3 times as much as that of the model group.Moreover,TLQT effectively reduced the inflammation in rat muscle.With RNA-seq analysis,230 differentially expressed genes were collected.The RT-qPCR results indicated that the mRNA expression level of NCF1,CXCL10,and ICAM1 all promoted in the model group,and then decreased significantly in the TLQT treated group.The ELISA results performed that the level of IL-1βand IL-6 in TLQT group high dose group was reduced by about 1.6-fold,and for TNF-α,it was reduced by about 2.6-fold compared with the model group.Immunohistochemistry assay showed that the expression level of CXCL10 and ICAM1 was both up-regulated in the model group and down-regulated in the TLQT group.Conclusion:TLQT plaster reduces chronic muscle pain by inhibiting the expression of NCF1,CXCL10,and ICAM1 and reducing the level of muscle tissue inflammation.
