With the intensification of climate change and ecological environmental degradation,the role of postgraduate landscape design disciplines in achieving sustainable development goals has become increasingly prominent.Na...With the intensification of climate change and ecological environmental degradation,the role of postgraduate landscape design disciplines in achieving sustainable development goals has become increasingly prominent.Nature-based Solutions(NbS),as an emerging concept,emphasize addressing social and environmental challenges through natural processes,offering a new direction for landscape design education.This study explored the reform of and reflections on landscape design courses for postgraduates guided by Nature-based Solutions.In response to the issues of disconnection between theory and practice and insufficient interdisciplinary integration in current graduate education in landscape design,this paper proposed a curriculum reform pathway oriented towards nature-based solutions.A new model for cultivating postgraduates in landscape design was explored by reconstructing the curriculum system,innovating teaching methods,and improving evaluation mechanisms.Moreover,drawing on the practical case of graduate teaching at Zhongyuan University of Technology,specific implementation strategies and outcomes of the curriculum reform were analyzed.This paper also reflected on the challenges encountered during the reform process and proposed corresponding optimization suggestions,aiming to provide a reference for the innovative development of graduate education in landscape design in China.展开更多
This study explores the status,challenges,and opportunities of smallholder aquaculture in the Leyte Sab-a Basin Peatland(LSBP),with a particular focus on the application of Nature-Based Solutions(NbS)for sustainable m...This study explores the status,challenges,and opportunities of smallholder aquaculture in the Leyte Sab-a Basin Peatland(LSBP),with a particular focus on the application of Nature-Based Solutions(NbS)for sustainable management.Using a mixed-methods approach that combines a comprehensive literature review with a focus group discussion(FGD)involving 22 local practitioners,the study identifies both traditional practices-such as bamboo pond structures and the use of Kangkong(Ipomoea aquatica)and Azolla as fish feed-and key constraints to productivity.These include environmental vulnerabilities(e.g.,declining water quality,climate variability),technical limitations(e.g.,disease risks,lack of fingerlings),and socio-economic barriers(e.g.,limited market access,financial insecurity,and gender inequality).While most smallholders are unfamiliar with formal NbS frameworks,their current practices already reflect ecological principles aligned with NbS.The study further highlights the socio-economic significance of aquaculture as both a livelihood resource and a contributor to food security in rural peatland communities.Linking traditional knowledge with scientifically guided NbS-such as Integrated Multi-Trophic Aquaculture(IMTA),aquaponics,and biofiltration systems-can enhance ecosystem resilience and livelihood security.In addition,strengthening gender-inclusive participation and providing equitable access to training and financial support are critical to improving resilience.This study concludes that targeted capacity-building,financial support mechanisms,and multi-stakeholder partnerships are needed to facilitate inclusive,sustainable,and climate-resilient aquaculture systems in peatland environments.Beyond addressing immediate livelihood changes,these strategies also contribute to biodiversity conservation,ecosystem restoration,and climate adaptation in fragile wetland landscapes.展开更多
Nature-based solutions(NBS)involve the sustainable maintenance,management,and restoration of natural or modified ecosystems.Flooding is a major problem in Phnom Penh,Cambodia,and has significant social and economic ra...Nature-based solutions(NBS)involve the sustainable maintenance,management,and restoration of natural or modified ecosystems.Flooding is a major problem in Phnom Penh,Cambodia,and has significant social and economic ramifications.This study tries to suggest creative solutions that support human welfare and biodiversity while simultaneously resolving social problems by adopting NBS.An online survey using convenience and snowball sampling was conducted to assess the openness of Phnom Penh residents to adopting NBS for flood mitigation in their homes or buildings.The survey investigated perceptions of NBS effectiveness based on previous knowledge and flood risk perception.Results revealed a strong correlation between perceived efficacy and willingness to adopt NBS.Specifically,flood risk perception and prior knowledge significantly influenced the perceived effectiveness of NBS.Key findings indicate that high installation and maintenance costs,lack of awareness,limited space,cultural factors,and perceived ineffectiveness are primary barriers to NBS adoption.Additionally,specific regional factors contribute to reluctance in certain areas of Phnom Penh.To overcome these barriers,the study recommends that the Cambodian government and other stakeholders invest in public education campaigns to raise awareness about the benefits of NBS.Financial incentives and subsidies should be provided to reduce the economic burden on residents.Furthermore,integrating NBS into urban planning and infrastructure development is crucial to enhance community resilience against floods.展开更多
Rotational grazing is considered as one of the nature-based solutions(NbS)to grassland protection by natural scientists.However,its effects on improving grassland quality are still unclear when it is adopted by herder...Rotational grazing is considered as one of the nature-based solutions(NbS)to grassland protection by natural scientists.However,its effects on improving grassland quality are still unclear when it is adopted by herders.Using a householdlevel panel data from field survey in two main pastoral provinces of China,empirical results from fixed-effect model and instrumental approach show that rotational grazing practices have insignificant short-term effects on grassland quality,but have positive long-term effects.In addition,rotational grazing practices can improve grassland quality when villages invest public infrastructure or herders have private supporting measures for more efficiency livestock production.Further analysis shows that herders adopting rotational grazing have higher grazing intensity,higher supplementary intensity and more livestock-house-feeding days,which indicate herders can utilize more efficient livestock management without increasing pressure on natural grassland.We also find that herders with pastoral income are more likely to adopt rotational grazing practice.These insightful findings offer policy implications on promoting grassroot NbS for ecosystem protection and resource utilization in developing pastoral countries.展开更多
This manuscript is an attempt to demonstrate effectiveness of nature-based solutions (NBS) and measures to reduce risk of flooding and environmental impact in urban settings. The nature-based solutions (NBS) were asse...This manuscript is an attempt to demonstrate effectiveness of nature-based solutions (NBS) and measures to reduce risk of flooding and environmental impact in urban settings. The nature-based solutions (NBS) were assessed as scenarios from experience of urban storm drainage and sewerage systems based on practices that improve urban water management through modelling using urban stormwater management model (SWMM). The model has been applied in a typical urban environment in the second city in Botswana, the City of Francistown, which has a population of more than one hundred thousand. By considering the 2-yr and 10-year storm events in a calibrated SWMM, NBS scenarios from a mix of low impact and drainage measures were considered. The considered NBS scenarios were used to determine their effectiveness in terms of reducing and controlling peak runoff, flood volumes, infiltration and evapotranspiration in the study area, which are vital in assessing the opportunity and challenge for sustainable management of water resources and associated tradeoff of investments in the urban contexts. The study demonstrates the usefulness of implementing effective measures for achieving NBS in urban context and possibility of outscaling at basin and regional levels.展开更多
The rapid pace of urbanization has led to the exacerbation of issues such as urban flooding,air pollution,and ecological degradation.In this context,the natural regulatory functions of urban open green spaces have eme...The rapid pace of urbanization has led to the exacerbation of issues such as urban flooding,air pollution,and ecological degradation.In this context,the natural regulatory functions of urban open green spaces have emerged as crucial elements in mitigating these challenges.From the perspective of nature-based solutions(NBS),Chulalongkorn Centennial Park serves as a case study for in-depth analysis.The objective is to investigate the role of urban open green spaces in environmental regulation.Furthermore,the research proposes scientific strategies for planning,design,and construction to enhance the ecological service functions and natural regulatory capacities of such spaces.展开更多
After an international contest announced by the City of Abu Dhabi “Cool Abu Dhabi Challenge”<sup>1</sup> and the article published as a digest of a paper titled A Nature-based Solution [1], the decision ...After an international contest announced by the City of Abu Dhabi “Cool Abu Dhabi Challenge”<sup>1</sup> and the article published as a digest of a paper titled A Nature-based Solution [1], the decision has been made to take part in improving thermal comfort in public spaces by mitigating the impact of the effect of Urban Heat Islands (UHI)<sup>2</sup> in the city of the Belgrade. The basic research aims at achieving the balance between the conflicting impacts when the buildings with their infrastructure and water-green surrounding area are in such correlation that it fulfils acceptable living and heating standards and reduces the use of fossil fuels for cooling the urban areas (buildings). By implementing the remote detection it is possible to analyze and quantify the impact of over-building on the temperature rise in urban areas as well as the disturbance of the heating comfort and the increased demand for additional cooling. Now it is possible to create virtual models that will incorporate this newly-added urban vegetation into urban plans, depending on the evaporation potential that will affect the microclimate of the urban area. Such natural cooling can be measured and adapted and hence aimed at a potential decrease in areas with UHI emissions [2]. Suitable greenery in the summer season can be a useful improvement which concurrently enables and complements several cooling mechanisms—evaporative cooling and evapotranspiration, i.e. natural cooling systems. The remote detection shall establish and map the “healthy” and “unhealthy” greenery zones—that is the vegetation zones with the highest evaporative potential with the “cooling by evaporation” effect and also, by implementing the urban prediction model, it shall propose green infrastructure corridors aimed at a potential decrease in the Urban Heat Island Emission.展开更多
Coastal erosion poses a major threat to low-elevation coastal zones such as Saint-Louis in Senegal,where rapid shoreline retreat has led to community displacement and infrastructure degradation.To address this challen...Coastal erosion poses a major threat to low-elevation coastal zones such as Saint-Louis in Senegal,where rapid shoreline retreat has led to community displacement and infrastructure degradation.To address this challenge,naturebased solutions(NbS)have been deployed within the Saint-Louis Marine Protected Area(MPA),notably the installation of“Typhavelles”structures made from Typha australis designed to promote dune formation and reduce erosion.This study assesses the effectiveness of“Typhavelles”using field data collected from 2019 to 2022,complemented by diachronic satellite imagery analysis.Results indicate a notable increase in beach width and dune development across the majority of monitored profiles.Shoreline change analysis reveals a dramatic shift from severe erosion(up to−94.5 m/year between 2017 and 2019)to significant accretion,reaching up to+136 m/year during the 2019-2021 period following the installation of the“Typhavelles”.These findings demonstrate that“Typhavelles”are effective in trapping sediment and stabilizing the coastline.However,their long-term viability may be compromised by sea level rise,sediment supply limitations,maintenance needs,and material biodegradation.The study highlights the promise of bio-inspired NbS for coastal protection and recommends enhancing“Typhavelles”durability through protective treatments to support broader replication in similar vulnerable coastal zones.展开更多
The global community is seeking novel approaches to address major global challenges such as climate change,sea-level rise,biodiversity loss,and public health.Nature-based Solutions(NbS)and the One Health Approach(OHA)...The global community is seeking novel approaches to address major global challenges such as climate change,sea-level rise,biodiversity loss,and public health.Nature-based Solutions(NbS)and the One Health Approach(OHA)are two promising pathways.NbS are actions to leverage the power of healthy ecosystems to protect people and nature and safeguard a stable and sustainable future[1].OHA is a pathway to safeguard water,food,and nutrient security and enhance our ability to tackle global health threats by emphasizing the interdependence be-tween people,plants,animals,and their shared environment[2].Obvi-ously,these two concepts share identical core values,that is,promoting ecosystem sustainability,mitigating global change,and benefiting nature and people in an integrative way.展开更多
Background In the climate change context,nature-based solution(NBS)is considered one of the effective tools to increase the resilience of socio-ecological system.The concept coincides with the government’s attempts o...Background In the climate change context,nature-based solution(NBS)is considered one of the effective tools to increase the resilience of socio-ecological system.The concept coincides with the government’s attempts of afforestation and reforestation programs that have been going on for 60 years in Bangladesh.This study,therefore,envisaged understanding how NBS(mangrove afforestation and reforestation)works to promote climate change resilience through the synthetization of remote sensing-based big earth data,statistical tools,and models.The study took the entire coast of Bangladesh except for Sundarbans Reserve Forest and rolled back to 1962 to work on 60 years’time series data.Declassified CORONA satellite imagery along with Landsat satellite imagery was used,which is the first-ever attempt in the remote sensing-based ecosystem work in Bangladesh.Results The study’s main innovation is to spatially establish the effectiveness of the NBS.The study critically assessed and estimated stable lands and their socio-economic benefits as part of the effectiveness of the NBS.As part of the NBS-derived benefits in the context of climate change,it estimated the sequestrated carbon in mangrove forests.A significant positive relationship was observed between the increase of mangroves and stable lands.Near about 448,011 ha of agricultural land was stabilized due to the NBS intervention whose economic value is 18,837 million USD.In addition,29,755.71 kt of carbon have been sequestrated due to NBS program.Conclusions The concept of NBS is still in the development stage and very little or no work has been done so far in measuring and labeling the effectiveness of the NBS.Therefore,our study can innovatively contribute to the scientific community to show the effectiveness of the NBS in three domains(social,economic and ecological)in the changing climatic scenario.展开更多
Nature-based solutions(NBS)are seen as a promising adaptation measure that sustainably deals with diverse societal challenges,while simultaneously delivering multiple benefits.Nature-based solutions have been highligh...Nature-based solutions(NBS)are seen as a promising adaptation measure that sustainably deals with diverse societal challenges,while simultaneously delivering multiple benefits.Nature-based solutions have been highlighted as a resilient and sustainable means of mitigating floods and other hazards globally.This study examined diverging conceptualizations of NBS,as well as the attitudinal(for example,emotions and beliefs)and contextual(for example,legal and political aspects)barriers and drivers of NBS for flood risks in South Korea.Semistructured interviews were conducted with 11 experts and focused on the topic of flood risk measures and NBS case studies.The analysis found 11 barriers and five drivers in the attitudinal domain,and 13 barriers and two drivers in the contextual domain.Most experts see direct monetary benefits as an important attitudinal factor for the public.Meanwhile,the cost-effectiveness of NBS and their capacity to cope with flood risks were deemed influential factors that could lead decision makers to opt for NBS.Among the contextual factors,insufficient systems to integrate NBS in practice and the ideologicalization of NBS policy were found to be peculiar barriers,which hinder consistent realization of initiatives and a long-term national plan for NBS.Understanding the barriers and drivers related to the mainstreaming of NBS is critical if we are to make the most of such solutions for society and nature.It is also essential that we have a shared definition,expectation,and vision of NBS.展开更多
In this study,a straightforward one-step hydrothermal method was successfully utilized to synthesize the solid solution Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)-Na_(2)Ni_(2)Ti_(6)O_(16)(NNMTO-x),where x denotes the molar perce...In this study,a straightforward one-step hydrothermal method was successfully utilized to synthesize the solid solution Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)-Na_(2)Ni_(2)Ti_(6)O_(16)(NNMTO-x),where x denotes the molar percentage of Na_(2)Ni_(2)Ti_(6)O_(16)(NNTO)within Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)(NMTO),with x values of 10,20,30,40,and 50.Both XPS(X-ray Photoelectron Spectroscopy)and EDX(Energy Dispersive X-ray Spectroscopy)analyses unequivocally validated the formation of the NNMTO-x solid solutions.It was observed that when x is below 40,the NNMTO-x solid solution retains the structural characteristics of the original NMTO.However,beyond this threshold,significant alterations in crystal morphology were noted,accompanied by a noticeable decline in photocatalytic activity.Notably,the absorption edge of NNMTO-x(x<40)exhibited a shift towards the visible-light spectrum,thereby substantially broadening the absorption range.The findings highlight that NNMTO-30 possesses the most pronounced photocatalytic activity for the reduction of CO_(2).Specifically,after a 6 h irradiation period,the production rates of CO and CH_(4)were recorded at 42.38 and 1.47μmol/g,respectively.This investigation provides pivotal insights that are instrumental in the advancement of highly efficient and stable photocatalysts tailored for CO_(2)reduction processes.展开更多
Substrate and nutrient supply are essential for vegetable cultivation in greenhouse.The strategies for plant nutrient supply vary depending on the cultivation methods or substrate dosages employed.With the development...Substrate and nutrient supply are essential for vegetable cultivation in greenhouse.The strategies for plant nutrient supply vary depending on the cultivation methods or substrate dosages employed.With the development of mechanization,wide-row spacing substrate cultivation became an optimize mode of the greenhouse cucumber cultivation,aligning with the trend of intelligent agriculture.To determine the optimal nutrient solution supply amount(NS)and supply frequency(SF)for promoting the integrated growth of cucumber under wide-row spacing substrate cultivation,we explored the effects of substrate supply amount(SS),NS,and SF on cucumber yield,quality,and element utilization efficiency.A five-level quadratic orthogonal rotation combination design with three experimental factors(NS,SF,and SS)was implemented for 23 coupling treatments over three growing seasons,including spring(2022S and 2023S)and autumn(2022A).The technique for order preference by similarity to ideal solution(TOPSIS)combining weights based on game theory was applied to construct cucumber comprehensive growth evaluation model.Single and two experimental factors analyses revealed significant effects of single factors and the coupling of NS-SS,NS-SF and SS-SF on the integrated growth of cucumber for all three growing seasons.For the NS-SF-SS combination,the optimal parameters for comprehensive cucumber growth were determined as follows:levels of^(-1).68 for NS,-0.7 for SF,and^(-1).682 for SS in 2022A;-0.43 for NS,-0.06 for SF,and 0.34 for SS in 2022S;0.3 for NS,-0.02 for SF,and 0.04 for SS in 2023S.Furthermore,for SS ranges of 2.00-3.01,3.01-4.50,4.50-5.99,5.99-7.00(L·plant^(-1)),the corresponding NS and SF intervals maximizing cucumber integrated growth in spring were:0.28-0.30(L·plant^(-1))and 6(times·d^(-1)),0.26-0.30(L·plant^(-1))and 6(times·d^(-1)),0.25-0.30(L·plant^(-1))and 6(times·d^(-1)),0.23-0.30(L·plant^(-1))and 6(times·d^(-1)),respectively.With the same SS,the corresponding NS and SF intervals that maximized cucumber integrated growth in autumn were:0.10(L·plant^(-1))and 8(times·d^(-1)),0.18(L·plant^(-1))and 7(times·d^(-1)),0.30(L·plant^(-1))and 6(times·d^(-1)),0.49(L·plant^(-1))and 5(times·d^(-1)),respectively.The results provide a theoretical basis for solution management,and further in-depth research on cucumber cultivation.展开更多
Titanium plates with a Ti−O solid solution surface-hardened layer were cold roll-bonded with 304 stainless steel plates with high work hardening rates.The evolution and mechanisms affecting the interfacial bonding str...Titanium plates with a Ti−O solid solution surface-hardened layer were cold roll-bonded with 304 stainless steel plates with high work hardening rates.The evolution and mechanisms affecting the interfacial bonding strength in titanium/stainless steel laminated composites were investigated.Results indicate that the hardened layer reduces the interfacial bonding strength from over 261 MPa to less than 204 MPa.During the cold roll-bonding process,the hardened layer fractures,leading to the formation of multi-scale cracks that are difficult for the stainless steel to fill.This not only hinders the development of an interlocking interface but also leads to the presence of numerous microcracks and hardened blocks along the nearly straight interface,consequently weakening the interfacial bonding strength.In metals with high work hardening rates,the conventional approach of enhancing interface interlocking and improving interfacial bonding strength by using a surface-hardened layer becomes less effective.展开更多
BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD....BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD.AIM To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus post-ESD.METHODS Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential ESD.Endoscopic examinations occurred on days 7 and 21 post-ESD.In vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was assessed.Profibrotic signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after ESD.After treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal layer.Additionally,the expression of fibrotic effector molecules was notably inhibited.Mechanistically,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/3.In vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen I.The 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated pEsF.CONCLUSION KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.展开更多
Tin(Sn)-lead(Pb)mixed halide perovskites have attracted widespread interest due to their wider re-sponse wavelength and lower toxicity than lead halide perovskites,Among the preparation methods,the two-step method mor...Tin(Sn)-lead(Pb)mixed halide perovskites have attracted widespread interest due to their wider re-sponse wavelength and lower toxicity than lead halide perovskites,Among the preparation methods,the two-step method more easily controls the crystallization rate and is suitable for preparing large-area per-ovskite devices.However,the residual low-conductivity iodide layer in the two-step method can affect carrier transport and device stability,and the different crystallization rates of Sn-and Pb-based per-ovskites may result in poor film quality.Therefore,Sn-Pb mixed perovskites are mainly prepared by a one-step method.Herein,a MAPb_(0.5)Sn_(0.5)I_(3)-based self-powered photodetector without a hole transport layer is fabricated by a two-step method.By adjusting the concentration of the ascorbic acid(AA)addi-tive,the final perovskite film exhibited a pure phase without residues,and the optimal device exhibited a high responsivity(0.276 A W^(-1)),large specific detectivity(2.38×10^(12) Jones),and enhanced stability.This enhancement is mainly attributed to the inhibition of Sn2+oxidation,the control of crystal growth,and the sufficient reaction between organic ammonium salts and bottom halides due to the AA-induced pore structure.展开更多
Ultrathin Li-rich Li-Cu binary alloy has become a competitive anode material for Li metal batteries of high energy density.However,due to the poor-lithiophilicity of the single skeleton structure of Li-Cu alloy,it has...Ultrathin Li-rich Li-Cu binary alloy has become a competitive anode material for Li metal batteries of high energy density.However,due to the poor-lithiophilicity of the single skeleton structure of Li-Cu alloy,it has limitations in inducing Li nucleation and improving electrochemical performance.Hence,we introduced Ag species to Li-Cu alloy to form a 30μm thick Li-rich Li-Cu-Ag ternary alloy(LCA)anode,with Li-Ag infinite solid solution as the active phase,and Cu-based finite solid solutions as three-dimensional(3D)skeleton.Such nano-wire networks with LiCu4 and CuxAgy finite solid solution phases were prepared through a facile melt coating technique,where Ag element can act as lithiophilic specie to enhance the lithiophilicity of built-in skeleton,and regulate the deposition behavior of Li effectively.Notably,the formation of CuxAgy solid solution can strengthen the structural stability of the skeleton,ensuring the geometrical integrity of Li anode,even at the fully delithiated state.Meanwhile,the Li-Ag infinite solid solution phase can promote the Li plating/stripping reversibility of the LCA anode with an improved coulombic efficiency(CE).The synergistic effect between infinite and finite solid solutions could render an enhanced electrochemical performance of Li metal batteries.The LCA|LCA symmetric cells showed a long lifespan of over 600 h with stable polarization voltage of 40 mV,in 1 mA·cm^(-2)/1 mAh·cm^(-2).In addition,the full cells matching our ultrathin LCA anode with 17.2 mg·cm^(-2)mass loading of LiFePO_(4) cathode,can continuously operate beyond 110 cycles at 0.5C,with a high capacity retention of 91.5%.Kindly check and confirm the edit made in the article title.展开更多
Colorectal cancer(CRC)is a prevalent malignancy worldwide,posing a significant public health concern.Mounting evidence has confirmed that timely early screening facilitates the detection of incipient CRC,thereby enhan...Colorectal cancer(CRC)is a prevalent malignancy worldwide,posing a significant public health concern.Mounting evidence has confirmed that timely early screening facilitates the detection of incipient CRC,thereby enhancing patient prognosis.Obviously,non-participation of asymptomatic individuals in screening programs hampers early diagnosis and may adversely affect long-term outcomes for CRC patients.In this letter,we provide a comprehensive overview of the current status of early screening practices,while also thoroughly examine the dilemmas and potential solutions associated with early screening for CRC.In response to these issues,we proffer a set of recommendations directed at governmental authorities and the general public,which focus on augmenting financial investment,establishing standardized screening protocols,advancing technological capabilities,and bolstering public awareness campaigns.The importance of collaborative efforts from various stakeholders cannot be overstated in the quest to enhance early detection rates and alleviate the societal burden of CRC.展开更多
The performance of Mg alloys is significantly influenced by the concentrations and solid solution behavior of the alloying elements.In this work,the solid solution behavior of 20 alloying elements in 190 ternary Mg al...The performance of Mg alloys is significantly influenced by the concentrations and solid solution behavior of the alloying elements.In this work,the solid solution behavior of 20 alloying elements in 190 ternary Mg alloy systems at 500℃are systematically investigated.The solid solution behavior of a set of two different alloying elements in Mg alloy systems are suggested to be classified into three categories:inclusivity,exclusivity and proportionality.Inclusivity classification indicates that the two alloying elements are inclusive inα-Mg,increasing the joint solubility of both elements.Exclusivity classification suggests that the two alloying elements have a low joint solid solubility inα-Mg,since they prefer to form stable second phases.For the proportionality classification,the solubility curve of the ternary Mg alloy systems is a straight line connecting the solubility points of the two sub-binary systems.The proposed classification theory was validated by key experiments and the calculation of formation energies.The interaction effects between alloying elements and the preference of formation of second phases are the main factors determining the solid solution behavior classifications.Based on the observed solid solution features of multi-component Mg alloys,principles for alloy design of different types of high-performance Mg alloys were proposed in this work.展开更多
Background:Isotonic crystalloids are recommended as the first choice for fluid therapy in acute pan-creatitis(AP),with normal saline(NS)and lactate Ringer’s(LR)used most often.Evidence based recom-mendations on the t...Background:Isotonic crystalloids are recommended as the first choice for fluid therapy in acute pan-creatitis(AP),with normal saline(NS)and lactate Ringer’s(LR)used most often.Evidence based recom-mendations on the type of fluid are conflicting and generally come from small single-center randomized controlled trials(RCTs).We therefore conducted a systematic review and meta-analysis to compare the effect of balanced solutions(BS)versus NS on patient-centered clinical outcomes in AP.Methods:From four databases searched up to October 2024,we included only RCTs of adult patients with AP that compared the use of BS(including LR,acetate Ringer’s,etc.)with NS.The primary out-come was the disease advances from AP to moderately severe and severe AP(MSAP/SAP).Trial sequential analyses(TSA)were conducted to control for type-I and type-II errors and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)was used to assess the quality of evidence.Results:Six RCTs were identified and included,involving 260 patients treated with BS and 298 patients with NS.Patients who received the BS had less MSAP/SAP[odds ratio(OR)=0.50,95%confidence in-terval(CI):0.29 to 0.85,P=0.01,I^(2)=0%;5 studies,299 patients],reduced the need of ICU admission(OR=0.60,95%CI:0.39 to 0.93,P=0.02,I^(2)=0%;5 studies,507 patients)and shorter length of hospital stay[mean difference(MD)=-0.88,95%CI:-1.48 to-0.28,P=0.004,I^(2)=0%;6 studies,558 patients;confirmed by TSA with high certainty]compared with those who received NS.The evidence for most of the clinical outcomes was rated as moderate to low due to the risk of bias,imprecision and inconsistency.Conclusions:BS,compared with NS,was associated with improved clinical outcomes in patients with AP.However,given the moderate to low quality of evidence for most of the outcomes assessed,further trials are warranted.展开更多
基金Supported by Postgraduate Education Reform and Quality Improvement Project of Henan Province in 2023(YIS2023JC12).
文摘With the intensification of climate change and ecological environmental degradation,the role of postgraduate landscape design disciplines in achieving sustainable development goals has become increasingly prominent.Nature-based Solutions(NbS),as an emerging concept,emphasize addressing social and environmental challenges through natural processes,offering a new direction for landscape design education.This study explored the reform of and reflections on landscape design courses for postgraduates guided by Nature-based Solutions.In response to the issues of disconnection between theory and practice and insufficient interdisciplinary integration in current graduate education in landscape design,this paper proposed a curriculum reform pathway oriented towards nature-based solutions.A new model for cultivating postgraduates in landscape design was explored by reconstructing the curriculum system,innovating teaching methods,and improving evaluation mechanisms.Moreover,drawing on the practical case of graduate teaching at Zhongyuan University of Technology,specific implementation strategies and outcomes of the curriculum reform were analyzed.This paper also reflected on the challenges encountered during the reform process and proposed corresponding optimization suggestions,aiming to provide a reference for the innovative development of graduate education in landscape design in China.
基金supported by the AQUADAPT Project of the International Institute of Rural Reconstruction(IIRR)―the Philippines and Cambodia jointly funded by IDRC(International Research Development Centre of Canada)and the Government of Canada’s International Climate Finance Initiative.Project Title:Building and Evidence base for Inclusive,Nature-based Climate Solutions in Smallscale Aquaculture for Sustainable Aquatic Food Systems:Philippines and Cambodia(IDRC Project Number:110229).
文摘This study explores the status,challenges,and opportunities of smallholder aquaculture in the Leyte Sab-a Basin Peatland(LSBP),with a particular focus on the application of Nature-Based Solutions(NbS)for sustainable management.Using a mixed-methods approach that combines a comprehensive literature review with a focus group discussion(FGD)involving 22 local practitioners,the study identifies both traditional practices-such as bamboo pond structures and the use of Kangkong(Ipomoea aquatica)and Azolla as fish feed-and key constraints to productivity.These include environmental vulnerabilities(e.g.,declining water quality,climate variability),technical limitations(e.g.,disease risks,lack of fingerlings),and socio-economic barriers(e.g.,limited market access,financial insecurity,and gender inequality).While most smallholders are unfamiliar with formal NbS frameworks,their current practices already reflect ecological principles aligned with NbS.The study further highlights the socio-economic significance of aquaculture as both a livelihood resource and a contributor to food security in rural peatland communities.Linking traditional knowledge with scientifically guided NbS-such as Integrated Multi-Trophic Aquaculture(IMTA),aquaponics,and biofiltration systems-can enhance ecosystem resilience and livelihood security.In addition,strengthening gender-inclusive participation and providing equitable access to training and financial support are critical to improving resilience.This study concludes that targeted capacity-building,financial support mechanisms,and multi-stakeholder partnerships are needed to facilitate inclusive,sustainable,and climate-resilient aquaculture systems in peatland environments.Beyond addressing immediate livelihood changes,these strategies also contribute to biodiversity conservation,ecosystem restoration,and climate adaptation in fragile wetland landscapes.
文摘Nature-based solutions(NBS)involve the sustainable maintenance,management,and restoration of natural or modified ecosystems.Flooding is a major problem in Phnom Penh,Cambodia,and has significant social and economic ramifications.This study tries to suggest creative solutions that support human welfare and biodiversity while simultaneously resolving social problems by adopting NBS.An online survey using convenience and snowball sampling was conducted to assess the openness of Phnom Penh residents to adopting NBS for flood mitigation in their homes or buildings.The survey investigated perceptions of NBS effectiveness based on previous knowledge and flood risk perception.Results revealed a strong correlation between perceived efficacy and willingness to adopt NBS.Specifically,flood risk perception and prior knowledge significantly influenced the perceived effectiveness of NBS.Key findings indicate that high installation and maintenance costs,lack of awareness,limited space,cultural factors,and perceived ineffectiveness are primary barriers to NBS adoption.Additionally,specific regional factors contribute to reluctance in certain areas of Phnom Penh.To overcome these barriers,the study recommends that the Cambodian government and other stakeholders invest in public education campaigns to raise awareness about the benefits of NBS.Financial incentives and subsidies should be provided to reduce the economic burden on residents.Furthermore,integrating NBS into urban planning and infrastructure development is crucial to enhance community resilience against floods.
基金supported by the National Natural Science Foundation of China(72173004 and 71773003)the Major Consulting Project of Chinese Academy of Engineering(2022-HZ-09)。
文摘Rotational grazing is considered as one of the nature-based solutions(NbS)to grassland protection by natural scientists.However,its effects on improving grassland quality are still unclear when it is adopted by herders.Using a householdlevel panel data from field survey in two main pastoral provinces of China,empirical results from fixed-effect model and instrumental approach show that rotational grazing practices have insignificant short-term effects on grassland quality,but have positive long-term effects.In addition,rotational grazing practices can improve grassland quality when villages invest public infrastructure or herders have private supporting measures for more efficiency livestock production.Further analysis shows that herders adopting rotational grazing have higher grazing intensity,higher supplementary intensity and more livestock-house-feeding days,which indicate herders can utilize more efficient livestock management without increasing pressure on natural grassland.We also find that herders with pastoral income are more likely to adopt rotational grazing practice.These insightful findings offer policy implications on promoting grassroot NbS for ecosystem protection and resource utilization in developing pastoral countries.
文摘This manuscript is an attempt to demonstrate effectiveness of nature-based solutions (NBS) and measures to reduce risk of flooding and environmental impact in urban settings. The nature-based solutions (NBS) were assessed as scenarios from experience of urban storm drainage and sewerage systems based on practices that improve urban water management through modelling using urban stormwater management model (SWMM). The model has been applied in a typical urban environment in the second city in Botswana, the City of Francistown, which has a population of more than one hundred thousand. By considering the 2-yr and 10-year storm events in a calibrated SWMM, NBS scenarios from a mix of low impact and drainage measures were considered. The considered NBS scenarios were used to determine their effectiveness in terms of reducing and controlling peak runoff, flood volumes, infiltration and evapotranspiration in the study area, which are vital in assessing the opportunity and challenge for sustainable management of water resources and associated tradeoff of investments in the urban contexts. The study demonstrates the usefulness of implementing effective measures for achieving NBS in urban context and possibility of outscaling at basin and regional levels.
基金Sponsored by Beijing Urban Governance Research Base of North China University of Technology(2024CSZL07)。
文摘The rapid pace of urbanization has led to the exacerbation of issues such as urban flooding,air pollution,and ecological degradation.In this context,the natural regulatory functions of urban open green spaces have emerged as crucial elements in mitigating these challenges.From the perspective of nature-based solutions(NBS),Chulalongkorn Centennial Park serves as a case study for in-depth analysis.The objective is to investigate the role of urban open green spaces in environmental regulation.Furthermore,the research proposes scientific strategies for planning,design,and construction to enhance the ecological service functions and natural regulatory capacities of such spaces.
文摘After an international contest announced by the City of Abu Dhabi “Cool Abu Dhabi Challenge”<sup>1</sup> and the article published as a digest of a paper titled A Nature-based Solution [1], the decision has been made to take part in improving thermal comfort in public spaces by mitigating the impact of the effect of Urban Heat Islands (UHI)<sup>2</sup> in the city of the Belgrade. The basic research aims at achieving the balance between the conflicting impacts when the buildings with their infrastructure and water-green surrounding area are in such correlation that it fulfils acceptable living and heating standards and reduces the use of fossil fuels for cooling the urban areas (buildings). By implementing the remote detection it is possible to analyze and quantify the impact of over-building on the temperature rise in urban areas as well as the disturbance of the heating comfort and the increased demand for additional cooling. Now it is possible to create virtual models that will incorporate this newly-added urban vegetation into urban plans, depending on the evaporation potential that will affect the microclimate of the urban area. Such natural cooling can be measured and adapted and hence aimed at a potential decrease in areas with UHI emissions [2]. Suitable greenery in the summer season can be a useful improvement which concurrently enables and complements several cooling mechanisms—evaporative cooling and evapotranspiration, i.e. natural cooling systems. The remote detection shall establish and map the “healthy” and “unhealthy” greenery zones—that is the vegetation zones with the highest evaporative potential with the “cooling by evaporation” effect and also, by implementing the urban prediction model, it shall propose green infrastructure corridors aimed at a potential decrease in the Urban Heat Island Emission.
文摘Coastal erosion poses a major threat to low-elevation coastal zones such as Saint-Louis in Senegal,where rapid shoreline retreat has led to community displacement and infrastructure degradation.To address this challenge,naturebased solutions(NbS)have been deployed within the Saint-Louis Marine Protected Area(MPA),notably the installation of“Typhavelles”structures made from Typha australis designed to promote dune formation and reduce erosion.This study assesses the effectiveness of“Typhavelles”using field data collected from 2019 to 2022,complemented by diachronic satellite imagery analysis.Results indicate a notable increase in beach width and dune development across the majority of monitored profiles.Shoreline change analysis reveals a dramatic shift from severe erosion(up to−94.5 m/year between 2017 and 2019)to significant accretion,reaching up to+136 m/year during the 2019-2021 period following the installation of the“Typhavelles”.These findings demonstrate that“Typhavelles”are effective in trapping sediment and stabilizing the coastline.However,their long-term viability may be compromised by sea level rise,sediment supply limitations,maintenance needs,and material biodegradation.The study highlights the promise of bio-inspired NbS for coastal protection and recommends enhancing“Typhavelles”durability through protective treatments to support broader replication in similar vulnerable coastal zones.
基金financially supported by the National Natural Science Foundation of China(Nos.42477224 and 41773123).
文摘The global community is seeking novel approaches to address major global challenges such as climate change,sea-level rise,biodiversity loss,and public health.Nature-based Solutions(NbS)and the One Health Approach(OHA)are two promising pathways.NbS are actions to leverage the power of healthy ecosystems to protect people and nature and safeguard a stable and sustainable future[1].OHA is a pathway to safeguard water,food,and nutrient security and enhance our ability to tackle global health threats by emphasizing the interdependence be-tween people,plants,animals,and their shared environment[2].Obvi-ously,these two concepts share identical core values,that is,promoting ecosystem sustainability,mitigating global change,and benefiting nature and people in an integrative way.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No.XDA19030105.
文摘Background In the climate change context,nature-based solution(NBS)is considered one of the effective tools to increase the resilience of socio-ecological system.The concept coincides with the government’s attempts of afforestation and reforestation programs that have been going on for 60 years in Bangladesh.This study,therefore,envisaged understanding how NBS(mangrove afforestation and reforestation)works to promote climate change resilience through the synthetization of remote sensing-based big earth data,statistical tools,and models.The study took the entire coast of Bangladesh except for Sundarbans Reserve Forest and rolled back to 1962 to work on 60 years’time series data.Declassified CORONA satellite imagery along with Landsat satellite imagery was used,which is the first-ever attempt in the remote sensing-based ecosystem work in Bangladesh.Results The study’s main innovation is to spatially establish the effectiveness of the NBS.The study critically assessed and estimated stable lands and their socio-economic benefits as part of the effectiveness of the NBS.As part of the NBS-derived benefits in the context of climate change,it estimated the sequestrated carbon in mangrove forests.A significant positive relationship was observed between the increase of mangroves and stable lands.Near about 448,011 ha of agricultural land was stabilized due to the NBS intervention whose economic value is 18,837 million USD.In addition,29,755.71 kt of carbon have been sequestrated due to NBS program.Conclusions The concept of NBS is still in the development stage and very little or no work has been done so far in measuring and labeling the effectiveness of the NBS.Therefore,our study can innovatively contribute to the scientific community to show the effectiveness of the NBS in three domains(social,economic and ecological)in the changing climatic scenario.
基金the support from the German Academic Exchange Service(DAAD)the support received from the Horizon 2020 RECONECT(Regenerating ECOsystems with Nature-based solutions for hydro-meteorological risk r EduCTion)project,under the Grant Agreement No.776866。
文摘Nature-based solutions(NBS)are seen as a promising adaptation measure that sustainably deals with diverse societal challenges,while simultaneously delivering multiple benefits.Nature-based solutions have been highlighted as a resilient and sustainable means of mitigating floods and other hazards globally.This study examined diverging conceptualizations of NBS,as well as the attitudinal(for example,emotions and beliefs)and contextual(for example,legal and political aspects)barriers and drivers of NBS for flood risks in South Korea.Semistructured interviews were conducted with 11 experts and focused on the topic of flood risk measures and NBS case studies.The analysis found 11 barriers and five drivers in the attitudinal domain,and 13 barriers and two drivers in the contextual domain.Most experts see direct monetary benefits as an important attitudinal factor for the public.Meanwhile,the cost-effectiveness of NBS and their capacity to cope with flood risks were deemed influential factors that could lead decision makers to opt for NBS.Among the contextual factors,insufficient systems to integrate NBS in practice and the ideologicalization of NBS policy were found to be peculiar barriers,which hinder consistent realization of initiatives and a long-term national plan for NBS.Understanding the barriers and drivers related to the mainstreaming of NBS is critical if we are to make the most of such solutions for society and nature.It is also essential that we have a shared definition,expectation,and vision of NBS.
基金Supported by the Doctoral Research Start-up Project of Yuncheng University(YQ-2023067)Project of Shanxi Natural Science Foundation(202303021211189)+1 种基金Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Provinces(20220036)Shanxi ProvinceIntelligent Optoelectronic Sensing Application Technology Innovation Center and Shanxi Province Optoelectronic Information Science and TechnologyLaboratory,Yuncheng University.
文摘In this study,a straightforward one-step hydrothermal method was successfully utilized to synthesize the solid solution Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)-Na_(2)Ni_(2)Ti_(6)O_(16)(NNMTO-x),where x denotes the molar percentage of Na_(2)Ni_(2)Ti_(6)O_(16)(NNTO)within Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)(NMTO),with x values of 10,20,30,40,and 50.Both XPS(X-ray Photoelectron Spectroscopy)and EDX(Energy Dispersive X-ray Spectroscopy)analyses unequivocally validated the formation of the NNMTO-x solid solutions.It was observed that when x is below 40,the NNMTO-x solid solution retains the structural characteristics of the original NMTO.However,beyond this threshold,significant alterations in crystal morphology were noted,accompanied by a noticeable decline in photocatalytic activity.Notably,the absorption edge of NNMTO-x(x<40)exhibited a shift towards the visible-light spectrum,thereby substantially broadening the absorption range.The findings highlight that NNMTO-30 possesses the most pronounced photocatalytic activity for the reduction of CO_(2).Specifically,after a 6 h irradiation period,the production rates of CO and CH_(4)were recorded at 42.38 and 1.47μmol/g,respectively.This investigation provides pivotal insights that are instrumental in the advancement of highly efficient and stable photocatalysts tailored for CO_(2)reduction processes.
基金supported by the China Agriculture Research System(Grant No.CARS-23-D06)the Key Research and Development Program of Shaanxi Province(Grant Nos.2024NC2-GJHX-29 and 2024NC-ZDCYL-05-08)Shaanxi Agricultural Collaborative Innovation and Extension Alliance Project(Grant No.LMZD202202).
文摘Substrate and nutrient supply are essential for vegetable cultivation in greenhouse.The strategies for plant nutrient supply vary depending on the cultivation methods or substrate dosages employed.With the development of mechanization,wide-row spacing substrate cultivation became an optimize mode of the greenhouse cucumber cultivation,aligning with the trend of intelligent agriculture.To determine the optimal nutrient solution supply amount(NS)and supply frequency(SF)for promoting the integrated growth of cucumber under wide-row spacing substrate cultivation,we explored the effects of substrate supply amount(SS),NS,and SF on cucumber yield,quality,and element utilization efficiency.A five-level quadratic orthogonal rotation combination design with three experimental factors(NS,SF,and SS)was implemented for 23 coupling treatments over three growing seasons,including spring(2022S and 2023S)and autumn(2022A).The technique for order preference by similarity to ideal solution(TOPSIS)combining weights based on game theory was applied to construct cucumber comprehensive growth evaluation model.Single and two experimental factors analyses revealed significant effects of single factors and the coupling of NS-SS,NS-SF and SS-SF on the integrated growth of cucumber for all three growing seasons.For the NS-SF-SS combination,the optimal parameters for comprehensive cucumber growth were determined as follows:levels of^(-1).68 for NS,-0.7 for SF,and^(-1).682 for SS in 2022A;-0.43 for NS,-0.06 for SF,and 0.34 for SS in 2022S;0.3 for NS,-0.02 for SF,and 0.04 for SS in 2023S.Furthermore,for SS ranges of 2.00-3.01,3.01-4.50,4.50-5.99,5.99-7.00(L·plant^(-1)),the corresponding NS and SF intervals maximizing cucumber integrated growth in spring were:0.28-0.30(L·plant^(-1))and 6(times·d^(-1)),0.26-0.30(L·plant^(-1))and 6(times·d^(-1)),0.25-0.30(L·plant^(-1))and 6(times·d^(-1)),0.23-0.30(L·plant^(-1))and 6(times·d^(-1)),respectively.With the same SS,the corresponding NS and SF intervals that maximized cucumber integrated growth in autumn were:0.10(L·plant^(-1))and 8(times·d^(-1)),0.18(L·plant^(-1))and 7(times·d^(-1)),0.30(L·plant^(-1))and 6(times·d^(-1)),0.49(L·plant^(-1))and 5(times·d^(-1)),respectively.The results provide a theoretical basis for solution management,and further in-depth research on cucumber cultivation.
基金supported by the National Key R&D Program of China (No. 2018YFA0707300)the National Natural Science Foundation of China (No. 52374376)the Introduction Plan for High end Foreign Experts, China (No. G2023105001L)。
文摘Titanium plates with a Ti−O solid solution surface-hardened layer were cold roll-bonded with 304 stainless steel plates with high work hardening rates.The evolution and mechanisms affecting the interfacial bonding strength in titanium/stainless steel laminated composites were investigated.Results indicate that the hardened layer reduces the interfacial bonding strength from over 261 MPa to less than 204 MPa.During the cold roll-bonding process,the hardened layer fractures,leading to the formation of multi-scale cracks that are difficult for the stainless steel to fill.This not only hinders the development of an interlocking interface but also leads to the presence of numerous microcracks and hardened blocks along the nearly straight interface,consequently weakening the interfacial bonding strength.In metals with high work hardening rates,the conventional approach of enhancing interface interlocking and improving interfacial bonding strength by using a surface-hardened layer becomes less effective.
基金Supported by Science and Technology Department of Sichuan Province,No.2020YFS0376National Natural Science Foundation of China,No.81900599Science and Technology Program of Hospital of TCM,Southwest Medical University,No.2022-CXTD-01.
文摘BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD.AIM To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus post-ESD.METHODS Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential ESD.Endoscopic examinations occurred on days 7 and 21 post-ESD.In vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was assessed.Profibrotic signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after ESD.After treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal layer.Additionally,the expression of fibrotic effector molecules was notably inhibited.Mechanistically,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/3.In vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen I.The 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated pEsF.CONCLUSION KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.
基金supported by the National Natural Science Foun-dation of China(Nos.52025028,52332008,52372214,52202273,and U22A20137)the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
文摘Tin(Sn)-lead(Pb)mixed halide perovskites have attracted widespread interest due to their wider re-sponse wavelength and lower toxicity than lead halide perovskites,Among the preparation methods,the two-step method more easily controls the crystallization rate and is suitable for preparing large-area per-ovskite devices.However,the residual low-conductivity iodide layer in the two-step method can affect carrier transport and device stability,and the different crystallization rates of Sn-and Pb-based per-ovskites may result in poor film quality.Therefore,Sn-Pb mixed perovskites are mainly prepared by a one-step method.Herein,a MAPb_(0.5)Sn_(0.5)I_(3)-based self-powered photodetector without a hole transport layer is fabricated by a two-step method.By adjusting the concentration of the ascorbic acid(AA)addi-tive,the final perovskite film exhibited a pure phase without residues,and the optimal device exhibited a high responsivity(0.276 A W^(-1)),large specific detectivity(2.38×10^(12) Jones),and enhanced stability.This enhancement is mainly attributed to the inhibition of Sn2+oxidation,the control of crystal growth,and the sufficient reaction between organic ammonium salts and bottom halides due to the AA-induced pore structure.
基金supported by the National Natural Science Foundation of China(Nos.22379019,52172184)Sichuan Science and Technology Program(No.2024YFHZ0313)S&T Special Program of Huzhou(No.2023GZ03)。
文摘Ultrathin Li-rich Li-Cu binary alloy has become a competitive anode material for Li metal batteries of high energy density.However,due to the poor-lithiophilicity of the single skeleton structure of Li-Cu alloy,it has limitations in inducing Li nucleation and improving electrochemical performance.Hence,we introduced Ag species to Li-Cu alloy to form a 30μm thick Li-rich Li-Cu-Ag ternary alloy(LCA)anode,with Li-Ag infinite solid solution as the active phase,and Cu-based finite solid solutions as three-dimensional(3D)skeleton.Such nano-wire networks with LiCu4 and CuxAgy finite solid solution phases were prepared through a facile melt coating technique,where Ag element can act as lithiophilic specie to enhance the lithiophilicity of built-in skeleton,and regulate the deposition behavior of Li effectively.Notably,the formation of CuxAgy solid solution can strengthen the structural stability of the skeleton,ensuring the geometrical integrity of Li anode,even at the fully delithiated state.Meanwhile,the Li-Ag infinite solid solution phase can promote the Li plating/stripping reversibility of the LCA anode with an improved coulombic efficiency(CE).The synergistic effect between infinite and finite solid solutions could render an enhanced electrochemical performance of Li metal batteries.The LCA|LCA symmetric cells showed a long lifespan of over 600 h with stable polarization voltage of 40 mV,in 1 mA·cm^(-2)/1 mAh·cm^(-2).In addition,the full cells matching our ultrathin LCA anode with 17.2 mg·cm^(-2)mass loading of LiFePO_(4) cathode,can continuously operate beyond 110 cycles at 0.5C,with a high capacity retention of 91.5%.Kindly check and confirm the edit made in the article title.
文摘Colorectal cancer(CRC)is a prevalent malignancy worldwide,posing a significant public health concern.Mounting evidence has confirmed that timely early screening facilitates the detection of incipient CRC,thereby enhancing patient prognosis.Obviously,non-participation of asymptomatic individuals in screening programs hampers early diagnosis and may adversely affect long-term outcomes for CRC patients.In this letter,we provide a comprehensive overview of the current status of early screening practices,while also thoroughly examine the dilemmas and potential solutions associated with early screening for CRC.In response to these issues,we proffer a set of recommendations directed at governmental authorities and the general public,which focus on augmenting financial investment,establishing standardized screening protocols,advancing technological capabilities,and bolstering public awareness campaigns.The importance of collaborative efforts from various stakeholders cannot be overstated in the quest to enhance early detection rates and alleviate the societal burden of CRC.
基金financially supported by National Natural Science Foundation of China(grant numbers:52171100,U20A20234)National Key R&D Program of China(grant number:2021YFB3701100)。
文摘The performance of Mg alloys is significantly influenced by the concentrations and solid solution behavior of the alloying elements.In this work,the solid solution behavior of 20 alloying elements in 190 ternary Mg alloy systems at 500℃are systematically investigated.The solid solution behavior of a set of two different alloying elements in Mg alloy systems are suggested to be classified into three categories:inclusivity,exclusivity and proportionality.Inclusivity classification indicates that the two alloying elements are inclusive inα-Mg,increasing the joint solubility of both elements.Exclusivity classification suggests that the two alloying elements have a low joint solid solubility inα-Mg,since they prefer to form stable second phases.For the proportionality classification,the solubility curve of the ternary Mg alloy systems is a straight line connecting the solubility points of the two sub-binary systems.The proposed classification theory was validated by key experiments and the calculation of formation energies.The interaction effects between alloying elements and the preference of formation of second phases are the main factors determining the solid solution behavior classifications.Based on the observed solid solution features of multi-component Mg alloys,principles for alloy design of different types of high-performance Mg alloys were proposed in this work.
文摘Background:Isotonic crystalloids are recommended as the first choice for fluid therapy in acute pan-creatitis(AP),with normal saline(NS)and lactate Ringer’s(LR)used most often.Evidence based recom-mendations on the type of fluid are conflicting and generally come from small single-center randomized controlled trials(RCTs).We therefore conducted a systematic review and meta-analysis to compare the effect of balanced solutions(BS)versus NS on patient-centered clinical outcomes in AP.Methods:From four databases searched up to October 2024,we included only RCTs of adult patients with AP that compared the use of BS(including LR,acetate Ringer’s,etc.)with NS.The primary out-come was the disease advances from AP to moderately severe and severe AP(MSAP/SAP).Trial sequential analyses(TSA)were conducted to control for type-I and type-II errors and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)was used to assess the quality of evidence.Results:Six RCTs were identified and included,involving 260 patients treated with BS and 298 patients with NS.Patients who received the BS had less MSAP/SAP[odds ratio(OR)=0.50,95%confidence in-terval(CI):0.29 to 0.85,P=0.01,I^(2)=0%;5 studies,299 patients],reduced the need of ICU admission(OR=0.60,95%CI:0.39 to 0.93,P=0.02,I^(2)=0%;5 studies,507 patients)and shorter length of hospital stay[mean difference(MD)=-0.88,95%CI:-1.48 to-0.28,P=0.004,I^(2)=0%;6 studies,558 patients;confirmed by TSA with high certainty]compared with those who received NS.The evidence for most of the clinical outcomes was rated as moderate to low due to the risk of bias,imprecision and inconsistency.Conclusions:BS,compared with NS,was associated with improved clinical outcomes in patients with AP.However,given the moderate to low quality of evidence for most of the outcomes assessed,further trials are warranted.
