BACKGROUND Not all neuropsychiatric(NP)manifestations in patients with systemic lupus erythematosus(SLE)are secondary to lupus.The clarification of the cause of NP symptoms influences therapeutic strategies for SLE.AI...BACKGROUND Not all neuropsychiatric(NP)manifestations in patients with systemic lupus erythematosus(SLE)are secondary to lupus.The clarification of the cause of NP symptoms influences therapeutic strategies for SLE.AIM To understand the attribution of psychiatric manifestations in a cohort of Chinese patients with SLE.METHODS This retrospective single-center study analyzed 160 inpatient medical records.Clinical diagnosis,which is considered the gold standard,was used to divide the subjects into a psychiatric SLE(PSLE)group(G1)and a secondary psychiatric symptoms group(G2).Clinical features were compared between these two groups.The sensitivity and specificity of the Italian attribution model were explored.RESULTS A total of 171 psychiatric syndromes were recorded in 138 patients,including 87 cases of acute confusional state,40 cases of cognitive dysfunction,18 cases of psychosis,and 13 cases each of depressive disorder and mania or hypomania.A total of 141(82.5%)syndromes were attributed to SLE.In contrast to G2 patients,G1 patients had higher SLE Disease Activity Index-2000 scores(21 vs 12,P=0.001),a lower prevalence of anti-beta-2-glycoprotein 1 antibodies(8.6%vs 25.9%,P=0.036),and a higher prevalence of anti-ribosomal ribonucleoprotein particle(rRNP)antibodies(39.0%vs 22.2%,P=0.045).The Italian attribution model exhibited a sensitivity of 95.0%and a specificity of 70.0%when the threshold value was set at 7.CONCLUSION Patients with PSLE exhibited increased disease activity.There is a correlation between PSLE and anti-rRNP antibodies.The Italian model effectively assesses multiple psychiatric manifestations in Chinese SLE patients who present with NP symptoms.展开更多
Estimation and attribution of evapotranspiration(ET)and its components under changing environment is still a challenge but is essential for understanding the mechanisms of water and energy transfer for regional water ...Estimation and attribution of evapotranspiration(ET)and its components under changing environment is still a challenge but is essential for understanding the mechanisms of water and energy transfer for regional water resources management.In this study,an improved hydrological model is developed to estimate evapotranspiration and its components,i.e.,evaporation(E)and transpiration(T)by integrated the advantages of hydrological modeling constrained by water balance and the water-carbon close relationships.Results show that the improved hydrological model could captures ET and its components well in the study region.During the past years,annual ET and E increase obviously about 2.40 and 1.42 mm/a,particularly in spring and summer accounting for 90%.T shows less increasement and mainly increases in spring while it decreases in summer.Precipitation is the dominant factor and contributes 74.1%and 90.0%increases of annual ET and E,while the attribution of T changes is more complex by coupling of the positive effects of precipitation,rising temperature and interactive influences,the negative effects of solar diming and elevated CO_(2).In the future,ET and its components tend to increase under most of the Shared Socioeconomic Pathways(SSP)scenarios except for T decreases under the very high emissions scenario(SSP5-8.5)based on the projections.From seasonal perspective,the changes of ET and the components are mainly in spring and summer accounting for 75%,while more slight changes are found in autumn and winter.This study highlights the effectiveness of estimating ET and its components by improving hydrological models within water-carbon coupling relationships,and more complex mechanisms of transpiration changes than evapotranspiration and evaporation changes under the interactive effects of climate variability and vegetation dynamics.Besides,decision makers should pay attention to the more increases in the undesirable E than desirable T.展开更多
Drought significantly constrains vegetation growth and reduces terrestrial carbon sinks.Currently,the spatiotemporal patterns and mechanisms of the differential impacts of soil and meteorological droughts on vegetatio...Drought significantly constrains vegetation growth and reduces terrestrial carbon sinks.Currently,the spatiotemporal patterns and mechanisms of the differential impacts of soil and meteorological droughts on vegetation productivity remain inadequately understood.In this study,we analyzed soil moisture(SM),vapor pressure deficit(VPD),and gross primary productivity(GPP)to investigate their spatiotemporal patterns and the combined effects on GPP over China.The results revealed that:(1)Soil drought and meteorological drought generally exhibited temporally synchronous trends across China.(2)GPP was predominantly affected by the combined and synchronous effects of both SM and VPD,although their effects displayed directional variability differences in certain regions.(3)SM demonstrated a greater relative importance on GPP than VPD across more than half of the regions in China,whereas deciduous broadleaf forests were the only vegetation type primarily affected by VPD.(4)Under the lag effects,both SM and VPD exhibited bidirectional Granger causality with GPP,with the interaction between VPD and GPP proving more pronounced than that of SM.Our research provides valuable insights into the mechanisms through which SM and VPD influence GPP,contributing to improved predictions vegetation productivity and implementing ecological restoration.展开更多
The discrepancy in the trends of the global zonal mean(GZM)intensity of the Hadley circulation(HCI)between reanalysis data and model simulations has been a problem for understanding the changes in HCI and the influenc...The discrepancy in the trends of the global zonal mean(GZM)intensity of the Hadley circulation(HCI)between reanalysis data and model simulations has been a problem for understanding the changes in HCI and the influence of external forcings.To understand the reason for this discrepancy,this study investigates the trends of intensity of regional HCI of the Northern Hemisphere over the eastern Pacific(EPA),western Pacific(WPA),Atlantic(ATL),Africa(AFR),the Indian Ocean(IDO),and residual area(RA),based on six reanalysis datasets and 13 CMIP6 models.In reanalysis data,the trends in regional HCI over EPA and ATL(WPA and AFR)contribute to(partially offset)the increasing trend in GZM HCI,while the trends in regional HCI over IDO are different in different reanalysis data.The CMIP6 models skillfully reproduce the trends in regional HCI over EPA,ATL,WPA,and AFR,but simulate notable decreasing trends in regional HCI over IDO,which is a key reason for the opposite trends in GZM HCI between reanalysis data and models.The discrepancy in IDO can be attributed to differences in the simulation of diabatic heating and zonal friction between reanalysis data and models.Optimal fingerprint analysis indicates that anthropogenic(ANT)and non-greenhouse gas(NOGHG)forcings are the dominant drivers of the HCI trends in the EPA and ATL regions.In the WPA(AFR)region,NOGHG(ANT)forcing serves as the primary driver.The findings contribute to improving the representation of regional HCI trends in models and improving the attribution of external forcings.展开更多
Attribute-Based Encryption(ABE)has emerged as a fundamental access control mechanism in data sharing,enabling data owners to define flexible access policies.A critical aspect of ABE is key revocation,which plays a piv...Attribute-Based Encryption(ABE)has emerged as a fundamental access control mechanism in data sharing,enabling data owners to define flexible access policies.A critical aspect of ABE is key revocation,which plays a pivotal role in maintaining security.However,existing key revocation mechanisms face two major challenges:(1)High overhead due to ciphertext and key updates,primarily stemming from the reliance on revocation lists during attribute revocation,which increases computation and communication costs.(2)Limited universality,as many attribute revocation mechanisms are tailored to specific ABE constructions,restricting their broader applicability.To address these challenges,we propose LUAR(Lightweight and Universal Attribute Revocation),a novel revocation mechanism that leverages Intel Software Guard Extensions(SGX)while minimizing its inherent limitations.Given SGX’s constrained memory(≈90 MB in a personal computer)and susceptibility to side-channel attacks,we carefully manage its usage to reduce reliance while mitigating potential collusion risks between cloud service providers and users.To evaluate LUAR’s lightweight and universality,we integrate it with the classic BSW07 scheme,which can be seamlessly replaced with other ABE constructions.Experimental results demonstrate that LUAR enables secure attribute revocation with low computation and communication overhead.The processing time within the SGX environment remains stable at approximately 55 ms,regardless of the complexity of access policies,ensuring no additional storage or computational burden on SGX.Compared to the Hardware-based Revocable Attribute-Based Encryption(HR-ABE)scheme(IEEE S&P 2024),LUAR incurs a slightly higher computational cost within SGX;however,the overall time from initiating a data request to obtaining plaintext is shorter.As access policies grow more complex,LUAR’s advantages become increasingly evident,showcasing its superior efficiency and broader applicability.展开更多
Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and mi...Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and middleincome countries(LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China.Methods: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction(PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus(HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method.Results: A total of 22.2%(2,112/9,526) of women were HR-HPV positive and HPV52(21.7%) was the most common HR-HPV genotype, followed by HPV58(18.2%), HPV53(18.2%) and HPV16(16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia(CIN)1 were HPV16(36.7%), HPV58(20.4%), HPV56(15.3%). Among CIN2+, the most frequent genotypes were HPV16(75.6%), HPV52(17.8%),HPV58(16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions,and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions.Conclusions: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population.展开更多
This study describes a previously unidentified Neoproterozoic mafic dyke emplaced in the northern flank of the Langshan Tectonic Belt. This dyke intruded into the micaquartz schist of the Zhaertaishan Group, and yield...This study describes a previously unidentified Neoproterozoic mafic dyke emplaced in the northern flank of the Langshan Tectonic Belt. This dyke intruded into the micaquartz schist of the Zhaertaishan Group, and yielded an age of 908 ± 8 Ma. The youngest U-Pb ages of micaquartz schist from the Zhaertaishan Group in the Langshan area were 1118 ± 33 Ma,1187 ± 3 Ma and 1189 ± 39 Ma,suggesting that the depositional age of the protolith of the schist was between 908 ± 8 Ma and 1118 ± 33 Ma. In addition, 436 U-Pb age data and 155 Lu-Hf isotopic data from six samples in the Langshan Tectonic Belt and one Permian greywacke from the Wuhai area show distinct differences between the northern and southern flanks of the Main Langshan area. The U-Pb ages of the northern flank are primarily Meso-Neoproterozoic; similar ages have not been identified in the southern flank to date.Moreover, two-stage Hf model ages of the northern flank feature three age peaks at ～900 Ma,～1700 Ma and ～2600 Ma; this differs from Hf model ages of the southern flank, which feature one strong age peak at ～2700 Ma. These results suggest that the northern and southern flanks of the Main Langshan area have different geochronologic characteristics and should be divided further. Based on the U-Pb ages and Hf model ages, the northern and southern flanks of the Main Langshan area are named the North and South Langshan Tectonic Belts. Comparison of the U-Pb age and two-stage Hf model age distributions from the North Langshan Tectonic Belt, South Langshan Tectonic Belt, Alxa Block and the North China Craton(NCC) reveal that the North Langshan Tectonic Belt is similar to the Alxa Block and that the South Langshan Tectonic Belt is similar to the NCC. In addition, the zircon U-Pb age of 860 ±7 Ma commonly observed in the Alxa Block was detected in the Permian greywacke from the Wuhai area of the NCC, which suggests that the amalgamation of the North and South Langshan Tectonic belts(i.e.,the amalgamation of the Alxa Block and the NCC), occurred between Devonian and late Permian.展开更多
The aim of this present study is to examine the efficacy of attribution retraining group therapy （ARGT） and to compare the responses of outpatients with major depression disorder （MDD）, generalized anxiety disord...The aim of this present study is to examine the efficacy of attribution retraining group therapy （ARGT） and to compare the responses of outpatients with major depression disorder （MDD）, generalized anxiety disorder （GAD） and obsessive-compulsive disorder （OCD）. We carried out a prospective uncontrolled intervention study with a 8-weeks of ARGT on sixty three outpatients with MDD, GAD or OCD. Hamilton rating scale for depression, Hamilton rating scale for anxiety, Yale-Brown obsessive-compulsive scale, attribution style questionnaire, self-esteem scale, index of well-being, and social disability screening schedule were administered before and after treatment. Significant improvement in symptoms and psychological and social functions from pre- to posttreatment occurred for all participants. The changes favored MDD patients. Our study suggested that ARGT may improve the symptoms and psychological-social functions of MDD, GAD, and OCD patients. MDD patients showed the best response.展开更多
To enable local water resource management and maintenance of ecosystem integrity and to protect and mitigate against flood and drought, it is necessary to determine changes in long-term series of streamflow and to dis...To enable local water resource management and maintenance of ecosystem integrity and to protect and mitigate against flood and drought, it is necessary to determine changes in long-term series of streamflow and to distinguish the roles that climate change and human disturbance play in these changes. A review of previous research on the detection and attribution of observed changes in annual runoff in China shows a decrease in annual runoff since the 1950s in northern China in areas such as the Songhuajiang River water resources zone, the Liaohe River water resources zone, the Haihe River water resources zone, the Yellow River water resources zone, and the Huaihe River water resources Zone. Furthermore, abrupt changes in annual runoff occurred mostly in the 1970s and 1980s in all the above zones, except for some of the sub-basins in the middle Yellow River where abrupt change occurred in the 1990s. Changes in annual runoff are found to be mainly caused by climate change in the western Songhuajiang River basin, the upper mainstream of the Yangtze River, and the western Pearl River basin, which shows that studies on the impact of climate change on future water resources under different climate change scenarios are required to enable planning and management by agencies in these river basins. However, changes in annual runoff were found to be mainly caused by human activities in most of the catchments in northern China (such as the southern Songhuajiang River, Liaohe River, Haihe River, the lower reach and some of the catchments within the middle Yellow River basin) and in middle-eastern China, such as the Huaihe River and lower mainstream of the Yangtze River. This suggests that current hydro-climatic data can continue to be used in water-use planning and that policymakers need to focus on water resource management and protection.展开更多
Extreme weather events and their consequential impacts have been a key feature of the climate in recent years in many parts of the world,with many partly attributed to ongoing global-scale warming.The past year,2022,h...Extreme weather events and their consequential impacts have been a key feature of the climate in recent years in many parts of the world,with many partly attributed to ongoing global-scale warming.The past year,2022,has been no exception,with further records being broken.The year was marked by unprecedented heatwaves and droughts with highly unusual spatial extent,duration and intensity,with one measure indicating an aggregated and overall intensity of extreme heat events worldwide not seen since at least 1950.The extreme drought measured by surface soil moisture covered 47.3%of global land areas in 2022,which was the second most widespread year since 1980.Here,we examine notable events of the year in five major regions of the world:China’s Yangtze River region,western Europe,the western U.S.,the Horn of Africa and central South America.For each event,we review the potential roles of circulation,oceanic forcing(especially the“triple-dip”La Niña)and anthropogenic climate change,with an aim of understanding the extreme events in 2022 from a global perspective.This will serve as a reference for mechanism understanding,prediction and attribution of extreme events.展开更多
Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem services.Capturing long-term forest disturbance and drivers at a regional scale is cruci...Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem services.Capturing long-term forest disturbance and drivers at a regional scale is crucial for sustainable forest management and biodiversity conservation.Methods:We used 30-m resolution Landsat time series images and the LandTrendr algorithm on the Google Earth Engine cloud platform to map forest disturbances at an annual time scale between 1990 and 2020 and attributed causal agents of forest disturbance,including fire,logging,road construction and insects,using disturbance properties and spectral and topographic variables in the random forest model.Results:The conventional and area-adjusted overall accuracies(OAs)of the forest disturbance map were 92.3% and 97.70%±0.06%,respectively,and the OA of mapping disturbance agents was 85.80%.The estimated disturbed forest area totalled 3313.13 km^(2)(approximately 2.31% of the total forest area in 1990)from 1990 to 2020,with considerable interannual fluctuations and significant regional differences.The predominant disturbance agent was fire,which comprised approximately 83.33% of the forest area disturbance,followed by logging(12.2%),insects(2.4%)and road construction(2.0%).Massive forest disturbances occurred mainly before 2000,and the post-2000 annual disturbance area significantly dropped by 55% compared with the pre-2000 value.Conclusions:This study provided spatially explicit and retrospective information on annual forest disturbance and associated agents in the HDMR.The findings suggest that China’s logging bans in natural forests combined with other forest sustainability programmes have effectively curbed forest disturbances in the HDMR,which has implications for enhancing future forest management and biodiversity conservation.展开更多
Ecosystem services,which include water yield services,have been incorporated into decision processes of regional land use planning and sustainable development.Spatial pattern characteristics and identification of fact...Ecosystem services,which include water yield services,have been incorporated into decision processes of regional land use planning and sustainable development.Spatial pattern characteristics and identification of factors that influence water yield are the basis for decision making.However,there are limited studies on the driving mechanisms that affect the spatial heterogeneity of ecosystem services.In this study,we used the Hengduan Mountain region in southwest China,with obvious spatial heterogeneity,as the research site.The water yield module in the InVEST software was used to simulate the spatial distribution of water yield.Also,quantitative attribution analysis was conducted for various geomorphological and climatic zones in the Hengduan Mountain region by using the geographical detector method.Influencing factors,such as climate,topography,soil,vegetation type,and land use type and pattern,were taken into consideration for this analysis.Four key findings were obtained.First,water yield spatial heterogeneity is influenced most by climate-related factors,where precipitation and evapotranspiration are the dominant factors.Second,the relative importance of each impact factor to the water yield heterogeneity differs significantly by geomorphological and climatic zones.In flat areas,the influence of evapotranspiration is higher than that of precipitation.As relief increases,the importance of precipitation increases and eventually,it becomes the most influential factor.Evapotranspiration is the most influential factor in a plateau climate zone,while in the mid-subtropical zone,precipitation is the main controlling factor.Third,land use type is also an important driving force in flat areas.Thus,more attention should be paid to urbanization and land use planning,which involves land use changes,to mitigate the impact on water yield spatial pattern.The fourth finding was that a risk detector showed that Primarosol and Anthropogenic soil areas,shrub areas,and areas with slope<5°and 250-350 should be recognized as water yield important zones,while the corresponding elevation values are different among different geomorphological and climatic zones.Therefore,the spatial heterogeneity and influencing factors in different zones should be fully con-sidered while planning the maintenance and protection of water yield services in the Hengduan Mountain region.展开更多
Using lAP AGCM simulation results for the period 1961-2005, summer hot days in China were calculated and then compared with observations. Generally, the spatial pattern of hot days is reasonably reproduced, with more ...Using lAP AGCM simulation results for the period 1961-2005, summer hot days in China were calculated and then compared with observations. Generally, the spatial pattern of hot days is reasonably reproduced, with more hot days found in northern China, the Yangtze and Huaihe River basin, the Chuan-Yu region, and southern Xinjiang. However, the model tends to overestimate the number of hot days in the above-mentioned regions, particularly in the Yangtze and Huaihe River basin where the simulated summer-mean hot days is 13 days more than observed when averaged over the whole region, and the maximum overestimation of hot days can reach 23 days in the region. Analysis of the probability distribution of daily maximum temperature （Trnax） suggests that the warm bias in the model-simulated Tmax contributes largely to the overestimation of hot days in the model. Furthermore, the discrepancy in the simulated variance of the Tmax distribution also plays a non- negligible role in the overestimation of hot days. Indeed, the latter can even account for 22% of the total bias of simulated hot days in August in the Yangtze and Huaihe River basin. The quantification of model bias from the mean value and variability can provide more information for further model improvement.展开更多
This review paper focuses on the application of the Granger causality technique to the study of the causes of recent global warming (a case of climatic attribution). A concise but comprehensive review is performed and...This review paper focuses on the application of the Granger causality technique to the study of the causes of recent global warming (a case of climatic attribution). A concise but comprehensive review is performed and particular attention is paid to the direct role of anthropogenic and natural forcings, and to the influence of patterns of natural variability. By analyzing both in-sample and out-of-sample results, clear evidences are obtained (e.g., the major role of greenhousegases radiative forcing in driving temperature, a recent causal decoupling between solar irradiance and temperature itself) together with interesting prospects of further research.展开更多
Long-term memory(LTM)in the climate system has been well recognized and applied in different research fields,but the origins of this property are still not clear.In this work,the authors contribute to this issue by st...Long-term memory(LTM)in the climate system has been well recognized and applied in different research fields,but the origins of this property are still not clear.In this work,the authors contribute to this issue by studying model simulations under different scenarios.The global mean temperatures from pre-industrial control runs(pi Control),historical(all forcings)simulations,natural forcing only simulations(Historical Nat),greenhouse gas forcing only simulations(Historical GHG),etc.,are analyzed using the detrended fluctuation analysis.The authors find that the LTM already exists in the pi Control simulations,indicating the important roles of internal natural variability in producing the LTM.By comparing the results among different scenarios,the LTM from the piControl runs is further found to be strengthened by adding natural forcings such as the volcanic forcing and the solar forcing.Accordingly,the observed LTM in the climate system is suggested to be mainly controlled by both the‘internal’natural variability and the‘external’natural forcings.The anthropogenic forcings,however,may weaken the LTM.In the projections from RCP2.6 to RCP8.5,a weakening trend of the LTM strength is found.In view of the close relations between the climate memory and the climate predictability,a reduced predictability may be expected in a warming climate.展开更多
A simple and facile gas chromatography-mass spectrometer （GC-MS） fingerprint of Su-He-Xiang-Wan （SHXW） was developed, the similarity analysis was conducted, and attribution of the major characteristic peaks was id...A simple and facile gas chromatography-mass spectrometer （GC-MS） fingerprint of Su-He-Xiang-Wan （SHXW） was developed, the similarity analysis was conducted, and attribution of the major characteristic peaks was identified for SHXW quality control. GC-MS analysis was performed on a QP2010 instrument （Shimadzu, Japan） equipped with a capillary column of RTX-5MS. The column temperature was initiated at 50℃, held for 5 min, increased at the rate of 3 ℃/min to 120 ℃, held for 2 min, and then increased at the rate of 4 ℃/min to 220℃, held for 10 min. Helium carrier gas was used at a constant flow rate of 1.3 mL/min. Mass conditions were ionization voltage, 70 eV; injector temperature, 250℃; ion source temperature, 250 ℃; splitting ratio, 30：1; full scan mode in the 40-500 Da mass ranges with rate of 0.2 s per scan. Attribution of the major characteristic peaks was identified for SHXW by comparing the chemical standards, references of Chinese herbal medicines and the negative controls of prescription samples （NC） of SHXW. With the help of the temperature-programmed retention indices （PTRIs） used together with mass spectra and chemical standards, 25 major characteristic peaks have been identified. Nine volatile medicinal materials were identified in the prescription of SHXW by attributing to the 27 major characteristic peaks. The results demonstrate that the proposed method is a powerful approach to quality control of complex herbal medicines.展开更多
The progress and advances of the detection and attribution of changes in the hydrological cycle in the IPCC Assessment Reports of WGI and WGII from 1990 to 2007 are reviewed. Accomplishment and endorsed by the joint E...The progress and advances of the detection and attribution of changes in the hydrological cycle in the IPCC Assessment Reports of WGI and WGII from 1990 to 2007 are reviewed. Accomplishment and endorsed by the joint Expert Meeting on Detection and Attribution in 2009, the Good Practice Guidance Paper （GPGP） for IPCC Lead Authors with its main content and characteristics are briefly introduced. Based on the review and the purpose of the GPGP, some characteristics on the detection and attribution of global warming and of changes in the hydrological cycle are presented.展开更多
基金Supported by STI2030-Major Projects,No.2021ZD0202001National Natural Science Foundation of China,No.T2341003Capital Funds for Health Improvement and Research,No.CFH 2022-2-4012.
文摘BACKGROUND Not all neuropsychiatric(NP)manifestations in patients with systemic lupus erythematosus(SLE)are secondary to lupus.The clarification of the cause of NP symptoms influences therapeutic strategies for SLE.AIM To understand the attribution of psychiatric manifestations in a cohort of Chinese patients with SLE.METHODS This retrospective single-center study analyzed 160 inpatient medical records.Clinical diagnosis,which is considered the gold standard,was used to divide the subjects into a psychiatric SLE(PSLE)group(G1)and a secondary psychiatric symptoms group(G2).Clinical features were compared between these two groups.The sensitivity and specificity of the Italian attribution model were explored.RESULTS A total of 171 psychiatric syndromes were recorded in 138 patients,including 87 cases of acute confusional state,40 cases of cognitive dysfunction,18 cases of psychosis,and 13 cases each of depressive disorder and mania or hypomania.A total of 141(82.5%)syndromes were attributed to SLE.In contrast to G2 patients,G1 patients had higher SLE Disease Activity Index-2000 scores(21 vs 12,P=0.001),a lower prevalence of anti-beta-2-glycoprotein 1 antibodies(8.6%vs 25.9%,P=0.036),and a higher prevalence of anti-ribosomal ribonucleoprotein particle(rRNP)antibodies(39.0%vs 22.2%,P=0.045).The Italian attribution model exhibited a sensitivity of 95.0%and a specificity of 70.0%when the threshold value was set at 7.CONCLUSION Patients with PSLE exhibited increased disease activity.There is a correlation between PSLE and anti-rRNP antibodies.The Italian model effectively assesses multiple psychiatric manifestations in Chinese SLE patients who present with NP symptoms.
基金supported by the Chongqing Natural Science Foundation Innovation-Driven Development Joint Funds(No.CSTB2025NSCQ-LZX0055)the Youth Innovation Promotion Association,CAS(No.2021385)+4 种基金the Fundamental Research Funds for the Central Universities of South-Central Minzu University(No.CZQ24028)the Hubei Provincial Natural Science Foundation of China(No.2023AFB782)the Program of China Scholarship Council(No.202407780001)the National Natural Science Foundation of China(No.51809008)the Fund for Academic Innovation Teams of South-Central Minzu University(No.XTZ24019).
文摘Estimation and attribution of evapotranspiration(ET)and its components under changing environment is still a challenge but is essential for understanding the mechanisms of water and energy transfer for regional water resources management.In this study,an improved hydrological model is developed to estimate evapotranspiration and its components,i.e.,evaporation(E)and transpiration(T)by integrated the advantages of hydrological modeling constrained by water balance and the water-carbon close relationships.Results show that the improved hydrological model could captures ET and its components well in the study region.During the past years,annual ET and E increase obviously about 2.40 and 1.42 mm/a,particularly in spring and summer accounting for 90%.T shows less increasement and mainly increases in spring while it decreases in summer.Precipitation is the dominant factor and contributes 74.1%and 90.0%increases of annual ET and E,while the attribution of T changes is more complex by coupling of the positive effects of precipitation,rising temperature and interactive influences,the negative effects of solar diming and elevated CO_(2).In the future,ET and its components tend to increase under most of the Shared Socioeconomic Pathways(SSP)scenarios except for T decreases under the very high emissions scenario(SSP5-8.5)based on the projections.From seasonal perspective,the changes of ET and the components are mainly in spring and summer accounting for 75%,while more slight changes are found in autumn and winter.This study highlights the effectiveness of estimating ET and its components by improving hydrological models within water-carbon coupling relationships,and more complex mechanisms of transpiration changes than evapotranspiration and evaporation changes under the interactive effects of climate variability and vegetation dynamics.Besides,decision makers should pay attention to the more increases in the undesirable E than desirable T.
基金National Key Research and Development Program,No.2021xjkk0303。
文摘Drought significantly constrains vegetation growth and reduces terrestrial carbon sinks.Currently,the spatiotemporal patterns and mechanisms of the differential impacts of soil and meteorological droughts on vegetation productivity remain inadequately understood.In this study,we analyzed soil moisture(SM),vapor pressure deficit(VPD),and gross primary productivity(GPP)to investigate their spatiotemporal patterns and the combined effects on GPP over China.The results revealed that:(1)Soil drought and meteorological drought generally exhibited temporally synchronous trends across China.(2)GPP was predominantly affected by the combined and synchronous effects of both SM and VPD,although their effects displayed directional variability differences in certain regions.(3)SM demonstrated a greater relative importance on GPP than VPD across more than half of the regions in China,whereas deciduous broadleaf forests were the only vegetation type primarily affected by VPD.(4)Under the lag effects,both SM and VPD exhibited bidirectional Granger causality with GPP,with the interaction between VPD and GPP proving more pronounced than that of SM.Our research provides valuable insights into the mechanisms through which SM and VPD influence GPP,contributing to improved predictions vegetation productivity and implementing ecological restoration.
基金the National Key Research and Development Program of China[grant number 2022YFF0801704].
文摘The discrepancy in the trends of the global zonal mean(GZM)intensity of the Hadley circulation(HCI)between reanalysis data and model simulations has been a problem for understanding the changes in HCI and the influence of external forcings.To understand the reason for this discrepancy,this study investigates the trends of intensity of regional HCI of the Northern Hemisphere over the eastern Pacific(EPA),western Pacific(WPA),Atlantic(ATL),Africa(AFR),the Indian Ocean(IDO),and residual area(RA),based on six reanalysis datasets and 13 CMIP6 models.In reanalysis data,the trends in regional HCI over EPA and ATL(WPA and AFR)contribute to(partially offset)the increasing trend in GZM HCI,while the trends in regional HCI over IDO are different in different reanalysis data.The CMIP6 models skillfully reproduce the trends in regional HCI over EPA,ATL,WPA,and AFR,but simulate notable decreasing trends in regional HCI over IDO,which is a key reason for the opposite trends in GZM HCI between reanalysis data and models.The discrepancy in IDO can be attributed to differences in the simulation of diabatic heating and zonal friction between reanalysis data and models.Optimal fingerprint analysis indicates that anthropogenic(ANT)and non-greenhouse gas(NOGHG)forcings are the dominant drivers of the HCI trends in the EPA and ATL regions.In the WPA(AFR)region,NOGHG(ANT)forcing serves as the primary driver.The findings contribute to improving the representation of regional HCI trends in models and improving the attribution of external forcings.
基金support from the National Key Research and Development Program of China(Grant No.2021YFF0704102)the Chongqing Education Commission Key Project of Science and Technology Research(Grant No.KJZD-K202400610)the Chongqing Natural Science Foundation General Project(Grant No.CSTB2025NSCQ-GPX1263).
文摘Attribute-Based Encryption(ABE)has emerged as a fundamental access control mechanism in data sharing,enabling data owners to define flexible access policies.A critical aspect of ABE is key revocation,which plays a pivotal role in maintaining security.However,existing key revocation mechanisms face two major challenges:(1)High overhead due to ciphertext and key updates,primarily stemming from the reliance on revocation lists during attribute revocation,which increases computation and communication costs.(2)Limited universality,as many attribute revocation mechanisms are tailored to specific ABE constructions,restricting their broader applicability.To address these challenges,we propose LUAR(Lightweight and Universal Attribute Revocation),a novel revocation mechanism that leverages Intel Software Guard Extensions(SGX)while minimizing its inherent limitations.Given SGX’s constrained memory(≈90 MB in a personal computer)and susceptibility to side-channel attacks,we carefully manage its usage to reduce reliance while mitigating potential collusion risks between cloud service providers and users.To evaluate LUAR’s lightweight and universality,we integrate it with the classic BSW07 scheme,which can be seamlessly replaced with other ABE constructions.Experimental results demonstrate that LUAR enables secure attribute revocation with low computation and communication overhead.The processing time within the SGX environment remains stable at approximately 55 ms,regardless of the complexity of access policies,ensuring no additional storage or computational burden on SGX.Compared to the Hardware-based Revocable Attribute-Based Encryption(HR-ABE)scheme(IEEE S&P 2024),LUAR incurs a slightly higher computational cost within SGX;however,the overall time from initiating a data request to obtaining plaintext is shorter.As access policies grow more complex,LUAR’s advantages become increasingly evident,showcasing its superior efficiency and broader applicability.
基金supported by the China Medical Board (CMB) (No: 16-255)Chinese Academy of Medical Science Initiative for Innovative Medicine (No: 2017-I2M1-002)
文摘Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and middleincome countries(LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China.Methods: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction(PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus(HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method.Results: A total of 22.2%(2,112/9,526) of women were HR-HPV positive and HPV52(21.7%) was the most common HR-HPV genotype, followed by HPV58(18.2%), HPV53(18.2%) and HPV16(16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia(CIN)1 were HPV16(36.7%), HPV58(20.4%), HPV56(15.3%). Among CIN2+, the most frequent genotypes were HPV16(75.6%), HPV52(17.8%),HPV58(16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions,and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions.Conclusions: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population.
基金supported by the National Natural Science Foundation of China (Grant No. 41473015)a research grant from the Institute of Crustal Dynamics, CEA (ZDJ2014-02+2 种基金 ZDJ2017-05)the Tutor Foundation of the China University of Geosciences (Beijing) (Grant No. 53200859400)the China Geological Survey Projects (Grant Nos. 12120114041401 and 12120113015700)
文摘This study describes a previously unidentified Neoproterozoic mafic dyke emplaced in the northern flank of the Langshan Tectonic Belt. This dyke intruded into the micaquartz schist of the Zhaertaishan Group, and yielded an age of 908 ± 8 Ma. The youngest U-Pb ages of micaquartz schist from the Zhaertaishan Group in the Langshan area were 1118 ± 33 Ma,1187 ± 3 Ma and 1189 ± 39 Ma,suggesting that the depositional age of the protolith of the schist was between 908 ± 8 Ma and 1118 ± 33 Ma. In addition, 436 U-Pb age data and 155 Lu-Hf isotopic data from six samples in the Langshan Tectonic Belt and one Permian greywacke from the Wuhai area show distinct differences between the northern and southern flanks of the Main Langshan area. The U-Pb ages of the northern flank are primarily Meso-Neoproterozoic; similar ages have not been identified in the southern flank to date.Moreover, two-stage Hf model ages of the northern flank feature three age peaks at ～900 Ma,～1700 Ma and ～2600 Ma; this differs from Hf model ages of the southern flank, which feature one strong age peak at ～2700 Ma. These results suggest that the northern and southern flanks of the Main Langshan area have different geochronologic characteristics and should be divided further. Based on the U-Pb ages and Hf model ages, the northern and southern flanks of the Main Langshan area are named the North and South Langshan Tectonic Belts. Comparison of the U-Pb age and two-stage Hf model age distributions from the North Langshan Tectonic Belt, South Langshan Tectonic Belt, Alxa Block and the North China Craton(NCC) reveal that the North Langshan Tectonic Belt is similar to the Alxa Block and that the South Langshan Tectonic Belt is similar to the NCC. In addition, the zircon U-Pb age of 860 ±7 Ma commonly observed in the Alxa Block was detected in the Permian greywacke from the Wuhai area of the NCC, which suggests that the amalgamation of the North and South Langshan Tectonic belts(i.e.,the amalgamation of the Alxa Block and the NCC), occurred between Devonian and late Permian.
基金supported by national science and technology support projects (No.2009BA177B07)Natural Science Foundation of Jiangsu Province,China (No.PBBS1-102350)
文摘The aim of this present study is to examine the efficacy of attribution retraining group therapy （ARGT） and to compare the responses of outpatients with major depression disorder （MDD）, generalized anxiety disorder （GAD） and obsessive-compulsive disorder （OCD）. We carried out a prospective uncontrolled intervention study with a 8-weeks of ARGT on sixty three outpatients with MDD, GAD or OCD. Hamilton rating scale for depression, Hamilton rating scale for anxiety, Yale-Brown obsessive-compulsive scale, attribution style questionnaire, self-esteem scale, index of well-being, and social disability screening schedule were administered before and after treatment. Significant improvement in symptoms and psychological and social functions from pre- to posttreatment occurred for all participants. The changes favored MDD patients. Our study suggested that ARGT may improve the symptoms and psychological-social functions of MDD, GAD, and OCD patients. MDD patients showed the best response.
文摘To enable local water resource management and maintenance of ecosystem integrity and to protect and mitigate against flood and drought, it is necessary to determine changes in long-term series of streamflow and to distinguish the roles that climate change and human disturbance play in these changes. A review of previous research on the detection and attribution of observed changes in annual runoff in China shows a decrease in annual runoff since the 1950s in northern China in areas such as the Songhuajiang River water resources zone, the Liaohe River water resources zone, the Haihe River water resources zone, the Yellow River water resources zone, and the Huaihe River water resources Zone. Furthermore, abrupt changes in annual runoff occurred mostly in the 1970s and 1980s in all the above zones, except for some of the sub-basins in the middle Yellow River where abrupt change occurred in the 1990s. Changes in annual runoff are found to be mainly caused by climate change in the western Songhuajiang River basin, the upper mainstream of the Yangtze River, and the western Pearl River basin, which shows that studies on the impact of climate change on future water resources under different climate change scenarios are required to enable planning and management by agencies in these river basins. However, changes in annual runoff were found to be mainly caused by human activities in most of the catchments in northern China (such as the southern Songhuajiang River, Liaohe River, Haihe River, the lower reach and some of the catchments within the middle Yellow River basin) and in middle-eastern China, such as the Huaihe River and lower mainstream of the Yangtze River. This suggests that current hydro-climatic data can continue to be used in water-use planning and that policymakers need to focus on water resource management and protection.
基金supported by the National Natural Science Foundation of China(Grant No.42075037 and 42275033)the UK–China Research and Innovation Partnership Fund through the Met Office Climate Science for Service Partnership(CSSP)-China programme as part of the Newton Fund.
文摘Extreme weather events and their consequential impacts have been a key feature of the climate in recent years in many parts of the world,with many partly attributed to ongoing global-scale warming.The past year,2022,has been no exception,with further records being broken.The year was marked by unprecedented heatwaves and droughts with highly unusual spatial extent,duration and intensity,with one measure indicating an aggregated and overall intensity of extreme heat events worldwide not seen since at least 1950.The extreme drought measured by surface soil moisture covered 47.3%of global land areas in 2022,which was the second most widespread year since 1980.Here,we examine notable events of the year in five major regions of the world:China’s Yangtze River region,western Europe,the western U.S.,the Horn of Africa and central South America.For each event,we review the potential roles of circulation,oceanic forcing(especially the“triple-dip”La Niña)and anthropogenic climate change,with an aim of understanding the extreme events in 2022 from a global perspective.This will serve as a reference for mechanism understanding,prediction and attribution of extreme events.
基金jointly funded by the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK04020103)National Natural Science Foundation of China(41971239)programme for provincial innovative team of the climate change study of the Greater Mekong Subregion(2019HC027).
文摘Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem services.Capturing long-term forest disturbance and drivers at a regional scale is crucial for sustainable forest management and biodiversity conservation.Methods:We used 30-m resolution Landsat time series images and the LandTrendr algorithm on the Google Earth Engine cloud platform to map forest disturbances at an annual time scale between 1990 and 2020 and attributed causal agents of forest disturbance,including fire,logging,road construction and insects,using disturbance properties and spectral and topographic variables in the random forest model.Results:The conventional and area-adjusted overall accuracies(OAs)of the forest disturbance map were 92.3% and 97.70%±0.06%,respectively,and the OA of mapping disturbance agents was 85.80%.The estimated disturbed forest area totalled 3313.13 km^(2)(approximately 2.31% of the total forest area in 1990)from 1990 to 2020,with considerable interannual fluctuations and significant regional differences.The predominant disturbance agent was fire,which comprised approximately 83.33% of the forest area disturbance,followed by logging(12.2%),insects(2.4%)and road construction(2.0%).Massive forest disturbances occurred mainly before 2000,and the post-2000 annual disturbance area significantly dropped by 55% compared with the pre-2000 value.Conclusions:This study provided spatially explicit and retrospective information on annual forest disturbance and associated agents in the HDMR.The findings suggest that China’s logging bans in natural forests combined with other forest sustainability programmes have effectively curbed forest disturbances in the HDMR,which has implications for enhancing future forest management and biodiversity conservation.
基金National Basic Research Program of China,No.2015CB452702National Natural Science Foundation of China,No.41571098.No.41530749+1 种基金National Key R&D Program of China,No.2017YFC1502903Major Consulting Project of Strategic Development Institute,Chinese Academy of Sciences,No.Y02015001。
文摘Ecosystem services,which include water yield services,have been incorporated into decision processes of regional land use planning and sustainable development.Spatial pattern characteristics and identification of factors that influence water yield are the basis for decision making.However,there are limited studies on the driving mechanisms that affect the spatial heterogeneity of ecosystem services.In this study,we used the Hengduan Mountain region in southwest China,with obvious spatial heterogeneity,as the research site.The water yield module in the InVEST software was used to simulate the spatial distribution of water yield.Also,quantitative attribution analysis was conducted for various geomorphological and climatic zones in the Hengduan Mountain region by using the geographical detector method.Influencing factors,such as climate,topography,soil,vegetation type,and land use type and pattern,were taken into consideration for this analysis.Four key findings were obtained.First,water yield spatial heterogeneity is influenced most by climate-related factors,where precipitation and evapotranspiration are the dominant factors.Second,the relative importance of each impact factor to the water yield heterogeneity differs significantly by geomorphological and climatic zones.In flat areas,the influence of evapotranspiration is higher than that of precipitation.As relief increases,the importance of precipitation increases and eventually,it becomes the most influential factor.Evapotranspiration is the most influential factor in a plateau climate zone,while in the mid-subtropical zone,precipitation is the main controlling factor.Third,land use type is also an important driving force in flat areas.Thus,more attention should be paid to urbanization and land use planning,which involves land use changes,to mitigate the impact on water yield spatial pattern.The fourth finding was that a risk detector showed that Primarosol and Anthropogenic soil areas,shrub areas,and areas with slope<5°and 250-350 should be recognized as water yield important zones,while the corresponding elevation values are different among different geomorphological and climatic zones.Therefore,the spatial heterogeneity and influencing factors in different zones should be fully con-sidered while planning the maintenance and protection of water yield services in the Hengduan Mountain region.
基金supported by the Special Scientific Research Fund of the Meteorological Public Welfare Profession of China[grant number GYHY01406021]National Key Research and Development Program[grant number 2016YFC0402702]the National Natural Science Foundation of China[grant numbers 41575095,41175073]
文摘Using lAP AGCM simulation results for the period 1961-2005, summer hot days in China were calculated and then compared with observations. Generally, the spatial pattern of hot days is reasonably reproduced, with more hot days found in northern China, the Yangtze and Huaihe River basin, the Chuan-Yu region, and southern Xinjiang. However, the model tends to overestimate the number of hot days in the above-mentioned regions, particularly in the Yangtze and Huaihe River basin where the simulated summer-mean hot days is 13 days more than observed when averaged over the whole region, and the maximum overestimation of hot days can reach 23 days in the region. Analysis of the probability distribution of daily maximum temperature （Trnax） suggests that the warm bias in the model-simulated Tmax contributes largely to the overestimation of hot days in the model. Furthermore, the discrepancy in the simulated variance of the Tmax distribution also plays a non- negligible role in the overestimation of hot days. Indeed, the latter can even account for 22% of the total bias of simulated hot days in August in the Yangtze and Huaihe River basin. The quantification of model bias from the mean value and variability can provide more information for further model improvement.
文摘This review paper focuses on the application of the Granger causality technique to the study of the causes of recent global warming (a case of climatic attribution). A concise but comprehensive review is performed and particular attention is paid to the direct role of anthropogenic and natural forcings, and to the influence of patterns of natural variability. By analyzing both in-sample and out-of-sample results, clear evidences are obtained (e.g., the major role of greenhousegases radiative forcing in driving temperature, a recent causal decoupling between solar irradiance and temperature itself) together with interesting prospects of further research.
基金supported by the National Natural Science Foundation of China grant number 41675088the CAS Pioneer Hundred Talents Program。
文摘Long-term memory(LTM)in the climate system has been well recognized and applied in different research fields,but the origins of this property are still not clear.In this work,the authors contribute to this issue by studying model simulations under different scenarios.The global mean temperatures from pre-industrial control runs(pi Control),historical(all forcings)simulations,natural forcing only simulations(Historical Nat),greenhouse gas forcing only simulations(Historical GHG),etc.,are analyzed using the detrended fluctuation analysis.The authors find that the LTM already exists in the pi Control simulations,indicating the important roles of internal natural variability in producing the LTM.By comparing the results among different scenarios,the LTM from the piControl runs is further found to be strengthened by adding natural forcings such as the volcanic forcing and the solar forcing.Accordingly,the observed LTM in the climate system is suggested to be mainly controlled by both the‘internal’natural variability and the‘external’natural forcings.The anthropogenic forcings,however,may weaken the LTM.In the projections from RCP2.6 to RCP8.5,a weakening trend of the LTM strength is found.In view of the close relations between the climate memory and the climate predictability,a reduced predictability may be expected in a warming climate.
基金Foundation item： Projects（21275164, 21075138） supported by the National Natural Science Foundation of China
文摘A simple and facile gas chromatography-mass spectrometer （GC-MS） fingerprint of Su-He-Xiang-Wan （SHXW） was developed, the similarity analysis was conducted, and attribution of the major characteristic peaks was identified for SHXW quality control. GC-MS analysis was performed on a QP2010 instrument （Shimadzu, Japan） equipped with a capillary column of RTX-5MS. The column temperature was initiated at 50℃, held for 5 min, increased at the rate of 3 ℃/min to 120 ℃, held for 2 min, and then increased at the rate of 4 ℃/min to 220℃, held for 10 min. Helium carrier gas was used at a constant flow rate of 1.3 mL/min. Mass conditions were ionization voltage, 70 eV; injector temperature, 250℃; ion source temperature, 250 ℃; splitting ratio, 30：1; full scan mode in the 40-500 Da mass ranges with rate of 0.2 s per scan. Attribution of the major characteristic peaks was identified for SHXW by comparing the chemical standards, references of Chinese herbal medicines and the negative controls of prescription samples （NC） of SHXW. With the help of the temperature-programmed retention indices （PTRIs） used together with mass spectra and chemical standards, 25 major characteristic peaks have been identified. Nine volatile medicinal materials were identified in the prescription of SHXW by attributing to the 27 major characteristic peaks. The results demonstrate that the proposed method is a powerful approach to quality control of complex herbal medicines.
基金supported by the National Basic Research Program of China(2010CB428406)the Ministry of Water Resources Commonwealth Project (200801001)
文摘The progress and advances of the detection and attribution of changes in the hydrological cycle in the IPCC Assessment Reports of WGI and WGII from 1990 to 2007 are reviewed. Accomplishment and endorsed by the joint Expert Meeting on Detection and Attribution in 2009, the Good Practice Guidance Paper （GPGP） for IPCC Lead Authors with its main content and characteristics are briefly introduced. Based on the review and the purpose of the GPGP, some characteristics on the detection and attribution of global warming and of changes in the hydrological cycle are presented.
