AIM: To track the short-term neck narrowing changes in Birmingham metal-on-metal hip resurfacing(MOMHR) patients. METHODS: Since 2001, the Center for Hip and Knee Replacement started a registry to prospectively collec...AIM: To track the short-term neck narrowing changes in Birmingham metal-on-metal hip resurfacing(MOMHR) patients. METHODS: Since 2001, the Center for Hip and Knee Replacement started a registry to prospectively collect data on hip and knee replacement patients. From June 2006 to October 2008, 139 MOMHR were performed at our center by two participate surgeons using Birmingham MOMHR prosthesis(Smith Nephew, United States). It is standard of care for patients to obtain low, anteriorposterior(LAP) pelvis radiographs immediately after MOMHR procedure and then at 3 mo, 1 year and 2 year follow up office visits. Inclusion criteria for the present study included patients who came back for follow up office visit at above mentioned time points and got LAP radiographs. Exclusion criteria include patients who missed more than two follow up time points and those with poor-quality X-rays. Two orthopaedic residency trained research fellows reviewed the X-rays independently at 4 time points, i.e., immediate after surgery, 3 mo, 1 year and 2 year. Neck-to-prosthesis ratio(NPR) was used as main outcome measure. Twenty cases were used as subjects to identify the reliability between two observers. An intraclass correlation coefficient at 0.8 was considered as satisfied. A paired t-test was used to evaluate the significant difference between different time points with P < 0.05 considered to be statistically significant.RESULTS: The mean NPRs were 0.852 ± 0.056, 0.839 ± 0.052, 0.835 ± 0.051, 0.83 ± 0.04 immediately, 3 mo, 1 year and 2 years post-operatively respectively. At 3 mo, NPR was significantly different from immediate postoperative X-ray(P < 0.001). There was no difference between 3 mo and 1 year(P = 0.14) and 2 years(P = 0.53). Femoral neck narrowing(FNN) exceeding 10% of the diameter of the neck was observed in only 4 patients(5.6%) at two years follow up. None of these patients developed a femoral neck fracture(FNF). CONCLUSION: Femoral neck narrowing after MOMHR occurred as early as 3 mo postoperatively, and stabilized thereafter. Excessive FNN was not common in patients within the first two years of surgery and was not correlated with risk of FNF.展开更多
We present here our investigations of the features of focused electron beam transport in free space at elevated pressures of a few pascals.We have explored the effect of the beam accelerating voltage,operating gas pre...We present here our investigations of the features of focused electron beam transport in free space at elevated pressures of a few pascals.We have explored the effect of the beam accelerating voltage,operating gas pressure,and magnetic focusing upon the trajectory of beam electrons in the crossover region,in particular on the beam convergence and divergence angles.It is shown that for the forevacuum pressure range of 2-5 Pa explored,a distinctive feature of the propagation of a focused electron beam with a current of up to 20 mA at an accelerating voltage of 10-20 kV is the difference in the angles of convergence(before the focus)and divergence(after the focus).Whereas at a low pressure of 2 Pa the divergence angle is smaller than the convergence angle,as the pressure increases the divergence angle increases and for pressures greater than 5 Pa the divergence angle is greater than the convergence angle.The results obtained were used in experiments on electron beam transport through a long narrow metal tube with a diameter of 5.8-9.2 mm and length of 10-30 cm.We show that for a 30 cm long tube of 7.5 mm diameter,the focused beam transmission can exceed 70%.展开更多
Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functi...Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome(BAC)clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated.This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC,outlining their genomic origins,molecular mechanisms,and biological significance.We highlight their roles in metabolic reprogramming,microRNA network modulation,and tumor progression,as well as their diagnostic and prognostic value in tissue and serum-based analyses.Finally,we discuss therapeutic opportunities and propose future directions to translate RP11-derived lncRNAs into clinically actionable biomarkers and targets for precision liver cancer therapy.展开更多
Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,...Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,genetics alone is not the decisive factor-environmental conditions also play a vital role in achieving a long life(Selinus O,2013).展开更多
This investigation focuses on the utilization of cucurbit[6]uril(Q[6])as the host compound for the development of long-lasting afterglow materials.By strategically manipulating the outer surface interactions of Q[6],c...This investigation focuses on the utilization of cucurbit[6]uril(Q[6])as the host compound for the development of long-lasting afterglow materials.By strategically manipulating the outer surface interactions of Q[6],classical aggregation-caused quenching(ACQ)compounds such as fluorescein sodium(FluNa)and calcein sodium(CalNa)were transformed into afterglow materials with varying colors and durations upon exposure to ultraviolet light.This transformation was facilitated through a host-vip doping method combined with coordination with metal ions.Even at a reduced doping concentration of 5×10^(-5)wt%,the materials exhibit remarkable afterglow properties,lasting up to 2 s,with a phosphorescence lifetime of up to 150 ms.Moreover,by adjusting the concentration of the vip compound,the persistent luminescence color of the materials could be easily transitioned from orange to yellow and subsequently to green.These findings suggest that the developed afterglow materials hold significant potential for multilevel anti-counterfeiting and information encryption applications when exposed to ultraviolet light.The supramolecular assembly strategy,which relies on the outer surface interactions of cucurbit[n]uril,offers a simpler and more efficient approach to crafting multi-color luminescent materials.Additionally,this method opens avenues for enhancing the application potential of aggregation-caused quenching(ACQ)compounds in various technological domains.展开更多
Hepatocellular carcinoma(HCC)is a highly lethal malignancy with limited treatment options,particularly for patients with advanced stages of the disease.Sorafenib,the standard first-line therapy,faces significant chall...Hepatocellular carcinoma(HCC)is a highly lethal malignancy with limited treatment options,particularly for patients with advanced stages of the disease.Sorafenib,the standard first-line therapy,faces significant challenges due to the development of drug resistance.Yu et al explored the mechanisms by which lncRNA KIF9-AS1 regulates the stemness and sorafenib resistance in HCC using a combination of cell culture,transfection,RNA immunoprecipitation,co-immunoprecipitation,and xenograft tumor models.They demonstrate that N6-methyladenosine-modified long non-coding RNA KIF9-AS1 acts as an oncogene in HCC.This modification involves methyltransferase-like 3 and insulin-like growth factor 2 mRNA-binding protein 1,which play critical roles in regulating KIF9-AS1.Furthermore,KIF9-AS1 stabilizes and upregulates short stature homeobox 2 by promoting its deubiquitination through ubiquitin-specific peptidase 1,thereby enhancing stemness and contributing to sorafenib resistance in HCC cells.These findings provide a theoretical basis for KIF9-AS1 as a diagnostic marker and therapeutic target for HCC,highlighting the need for further investigation into its clinical application potential.展开更多
This paper mainly studies the well-posedness of steady incompressible impinging jet flow problem through a 3D axisymmetric finitely long nozzle.This problem originates from the physical phenomena encountered in practi...This paper mainly studies the well-posedness of steady incompressible impinging jet flow problem through a 3D axisymmetric finitely long nozzle.This problem originates from the physical phenomena encountered in practical engineering fields,such as in short take-off and vertical landing(STOVL)aircraft.Nowadays many intricate phenomena associated with impinging jet flows remain inadequately elucidated,which limits the ability to optimize aircraft design.Given a boundary condition in the inlet,the impinging jet problem is transformed into a Bernoulli-type free boundary problem according to the stream function.Then the variational method is used to study the corresponding variational problem with one parameter,thereby the wellposedness is established.The main conclusion is as follows.For a 3D axisymmetric finitely long nozzle and an infinitely long vertical wall,given an axial velocity in the inlet of nozzle,there exists a unique smooth incom‑pressible impinging jet flow such that the free boundary initiates smoothly at the endpoint of the nozzle and extends to infinity along the vertical wall at far fields.The key point is to investigate the regularity of the corner where the nozzle and the vertical axis intersect.展开更多
Deep learning plays a vital role in real-life applications, for example object identification, human face recognition, speech recognition, biometrics identification, and short and long-term forecasting of data. The ma...Deep learning plays a vital role in real-life applications, for example object identification, human face recognition, speech recognition, biometrics identification, and short and long-term forecasting of data. The main objective of our work is to predict the market performance of the Dhaka Stock Exchange (DSE) on day closing price using different Deep Learning techniques. In this study, we have used the LSTM (Long Short-Term Memory) network to forecast the data of DSE for the convenience of shareholders. We have enforced LSTM networks to train data as well as forecast the future time series that has differentiated with test data. We have computed the Root Mean Square Error (RMSE) value to scrutinize the error between the forecasted value and test data that diminished the error by updating the LSTM networks. As a consequence of the renovation of the network, the LSTM network provides tremendous performance which outperformed the existing works to predict stock market prices.展开更多
BACKGROUND Intracranial blister-like microaneurysms are an extremely rare disease.Rupture of intracranial aneurysms can lead to subarachnoid hemorrhage(SAH).Patients with SAH may experience severe neurological symptom...BACKGROUND Intracranial blister-like microaneurysms are an extremely rare disease.Rupture of intracranial aneurysms can lead to subarachnoid hemorrhage(SAH).Patients with SAH may experience severe neurological symptoms,including severe headache,nausea,vomiting,transient or persistent loss of consciousness,limb weakness,and blurred vision.Ruptured aneurysms should be surgically treated as soon as possible.Intravascular electrocoagulation is becoming a promising treatment method for intracranial blister-like microaneurysms.The short-term follow-up results demonstrated that this method is safe and effective.This article presents a case of endovascular electrocoagulation for the treatment of a blisterlike microaneurysm.CASE SUMMARY This article reports the case of 71-year-old female patient with an intracranial aneurysm.The patient experienced a sudden headache with vomiting for 3 hours.Brain computed tomography(CT)scan showed a subarachnoid hemorrhage.She was diagnosed with rupture of an aneurysm and subarachnoid hemorrhage.The aneurysm was located in the choroidal segment of the right internal carotid artery.The size of the aneurysm was 2.00 mm×1.80 mm×1.97 mm,and the neck of the aneurysm was less than 0.5 mm wide.We successfully treated this aneurysm with endovascular electrocoagulation,and the patient was safely returned to the ward and discharged after subsequent supportive treatment.CT angiography reexamination 3 months after surgery revealed no contrast agent extravasation in the original lesion,with a good prognosis.CONCLUSION Endovascular electrocoagulation is an effective and safe method for the treatment of intracranial blister-like microaneurysms.展开更多
Narrow backfill earth pressure estimation is applied to study the stability of supporting structures in the vicinity of existing buildings.Previous narrow backfill earth pressure studies have neglected seismic-unsatur...Narrow backfill earth pressure estimation is applied to study the stability of supporting structures in the vicinity of existing buildings.Previous narrow backfill earth pressure studies have neglected seismic-unsaturated seepage multi-field coupling,resulting in inaccurate estimates.To address these deficiencies,this paper proposed a calculation method for seismic passive earth pressure in unsaturated narrow backfill,based on inclined thin-layer units.It considers the interlayer shear stress,arching effect,and the multi-field coupling of seismic-unsaturated seepage.Additionally,this paper includes a parametric sensitivity analysis.The outcomes indicate that the earthquake passive ground pressure of unsaturated narrow backfill can be reduced by increasing the aspect ratio,seismic acceleration coefficient,and unsaturation parameterα.It can also be reduced by decreasing the effective interior friction angle,soil cohesion,wallearth friction angle,and vertical discharge.Furthermore,for any width soil,lowering the elevation of the action point of passive thrust can be attained by raising the effective interior friction angle,wall-earth friction angle,and unsaturation parameterα.Reducing soil cohesion,seismic acceleration coefficient,and vertical discharge can also lower the height of the application point of passive thrust.展开更多
Organic-inorganic hybrid solar cells consisting of organic conjugated materials and inorganic quantum dots(QDs)have been of great interest during the past two decades.However,it is still challenging to select desired ...Organic-inorganic hybrid solar cells consisting of organic conjugated materials and inorganic quantum dots(QDs)have been of great interest during the past two decades.However,it is still challenging to select desired organic functional materials for fabricating hybrid films to maximize their photovoltaic performance.Herein,we report the synthesis of three narrow bandgap non-fullerene conjugated polymers and further demonstrate the importance and impact of polymer crystallinity in tuning the organic-inorganic hybrid interface towards improved photovoltaic performance.In specific,we develop an organic-inorganic hybrid active layer using a newly synthesized polymer with relatively weaker crystallinity and FAPbI_(3)QDs,enabling complementary absorption and favorable interface/morphology for efficient charge separation and transport.The champion PCDOT-T/FAPbI_(3)QD hybrid device achieves a record-high efficiency of 13.11%based on the one-step coating organic/QD hybrid bulk heterojunction blend,which is significantly improved relative to the semi-crystalline polymer PYIT-based hybrid device(11.23%)and pristine QD(10.51%).We believe these findings would provide new insight into the organic/QD interface to construct desired hybrid films for high-performing optoelectronic applications.展开更多
Background:Over 65 million people have long COVID.Evidence for using Chinese herbal medicine(CHM)to treat long COVID is growing.A systematic review of evidence for guiding clinical decision is warranted.Objective:To e...Background:Over 65 million people have long COVID.Evidence for using Chinese herbal medicine(CHM)to treat long COVID is growing.A systematic review of evidence for guiding clinical decision is warranted.Objective:To examine the effects and safety of CHM in alleviating the severity of dyspnea,fatigue,exercise intolerance,depression,anxiety and insomnia in long COVID adults based on registered randomized clinical trials(RCT).Search strategy:World Health Organization International Clinical Trials Registry Platform and Chinese Clinical Trial Registry were searched for registered trial protocols from database inception to February 10,2023.English(PubM ed,Embase,AMED and CINAHL)and Chinese databases(CNKI,Wanfang Data and CQVIP)were then searched to identify relevant publications from December 2019 through April 6,2023.Inclusion criteria:Registered RCTs that compared the effects of Chinese herbal medicines or Chinese herbal formulas against a control treatment(i.e.,the placebo or usual care)in adults with persistent symptoms of long COVID.The primary outcome of dyspnea,and secondary outcomes of fatigue,exercise intolerance,depression,anxiety and insomnia were measured using validated tools at the end of the treatment.Data extraction and analysis:Data were extracted,and eligible RCTs were evaluated using version 2 of the Cochrane risk-of-bias tool for randomized trials and Grading of Recommendations,Assessment,Development and Evaluations independently by two researchers.Effect sizes were estimated by randomeffects modelling and mean difference(MD).Heterogeneity between trials was quantified by I^(2).Results:Among the 38 registered clinical trials we identified,seven RCTs(1,519 patients)were included in the systematic review.One RCT had a low overall risk of bias.Compared to the control,CHM reduces dyspnea on the Borg Dyspnea Scale score(MD=–0.2,95%confidence interval[CI]=–0.65 to 0.25)with moderate certainty,and reduces fatigue on the Borg Scale(MD=–0.48,95%CI=–0.74 to–0.22)with low certainty.CHM clinically reduces depression on Hamilton Depression Rating Scale score(MD=–6.00,95%CI=–7.56 to–4.44)and anxiety on Hamilton Anxiety Rating Scale score(MD=–6.10,95%CI=–7.67 to–4.53),and reduces insomnia on the Insomnia Severity Index(MD=–4.86,95%CI=–12.50 to 2.79)with moderate certainty.Meta-analysis of two RCTs(517 patients)showed that CHM clinically improves exercise intolerance by increasing 6-minute walking distance(MD=–15.92,95%CI=–10.20 to 42.05)with substantial heterogeneity(I^(2)=68%)and low certainty.Conclusion:CHM is associated with a post-treatment clinical reduction in depression and anxiety in long COVID adults,compared to the control,but it does not have a strong treatment effect on dyspnea and insomnia.Effects of CHM on exercise intolerance and fatigue are uncertain,and the safety of using CHM remains questionable.展开更多
The reignition of aero-engine combustors at high altitudes poses significant challenges due to the low-temperature and low-pressure environment.A novel Long Pulse-Width Plasma Ignition(LPWPI)system has been developed ...The reignition of aero-engine combustors at high altitudes poses significant challenges due to the low-temperature and low-pressure environment.A novel Long Pulse-Width Plasma Ignition(LPWPI)system has been developed to enhance ignition performance.The LPWPI system can effectively prolong the discharge duration time,improve ignition efficacy,and increase the plasma penetration depth.Experimental comparisons with the traditional Spark Ignition(SI)system demonstrate that the LPWPI increased discharge duration to 2.03 ms,which is 45 times longer than that of the SI system,while also doubling the spark penetration depth to 24.1 mm.The LPWPI system achieved a discharge efficiency of 61.1%,significantly surpassing the SI system's efficiency of23.3%.These advancements facilitated an extension of the lean ignition boundary by approximately 22.7%to 39.3%.High-speed camera recordings reveal that the spark duration of the LPWPI system was extended to 2.1 ms,compared to 0.6 ms in the SI system.Ignition progress with LPWPI shows a sustained spark kernel without the flame residence stage observed in the SI system.The impressive performance of the LPWPI system suggests that it is a promising alternative for aero-engine ignition systems.展开更多
The published article titled“Overexpression of long noncoding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells”has been retracted from Oncology Research,Vol.26,N...The published article titled“Overexpression of long noncoding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells”has been retracted from Oncology Research,Vol.26,No.6,2018,pp.869–878.展开更多
The published article titled“Long Noncoding RNA SChLAP1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Targeting miR-198 and Promoting the MAPK1 Pathway”has been retracted from Oncology Research...The published article titled“Long Noncoding RNA SChLAP1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Targeting miR-198 and Promoting the MAPK1 Pathway”has been retracted from Oncology Research,Vol.26,No.1,2018,pp.131–143.展开更多
Soybean seed isoflavones are a type of secondary metabolites that can provide health and nutrition benefits for humans. In our previous study, a stable quantitative trait locus(QTL) qIF05-1 controlling the seed isofla...Soybean seed isoflavones are a type of secondary metabolites that can provide health and nutrition benefits for humans. In our previous study, a stable quantitative trait locus(QTL) qIF05-1 controlling the seed isoflavone content in soybean was detected on chromosome(Chr.) 05 in a recombinant inbred line(RIL) population from a cross of Huachun 2×Wayao. In this study, the parental lines were re-sequenced using the Illumina Solexa System with deep coverage. A total of 63,099 polymorphic long insertions and deletions(InDels)(≥15 bp)were identified between the parents Huachun 2 and Wayao. The InDels were unevenly distributed on 20chromosomes of soybean, varying from 1,826 in Chr. 12 to 4,544 in Chr. 18. A total of 10,002 long InDels(15.85% of total) were located in genic regions, including 1,139 large-effect long InDels which resulted in truncated or elongated protein sequences. In the qIF05-1 region, 68 long InDels were detected between the two parents. Using a progeny recombination experiment and genotype analysis, the qIF05-1 locus was mapped into a 102.2 kb genomic region, and this region contained 12 genes. By RNA-seq data analysis, genome sequence comparison and functional validation through ectopic expression in Arabidopsis thaliana, Glyma.05G208300(described as GmEGL3), which is a basic helix-loop-helix(bHLH) transcription factor in plants, emerged as the most likely confirmed gene in qIF05-1. These long InDels can be used as a type of complementary genetic method for QTL fine mapping, and they can facilitate genetic studies and molecular-assisted selection breeding in soybean.展开更多
Over the past few years,Malware attacks have become more and more widespread,posing threats to digital assets throughout the world.Although numerous methods have been developed to detect malicious attacks,these malwar...Over the past few years,Malware attacks have become more and more widespread,posing threats to digital assets throughout the world.Although numerous methods have been developed to detect malicious attacks,these malware detection techniques need to be more efficient in detecting new and progressively sophisticated variants of malware.Therefore,the development of more advanced and accurate techniques is necessary for malware detection.This paper introduces a comprehensive Dual-Channel Attention Deep Bidirectional Long Short-Term Memory(DCADBiLSTM)model for malware detection and riskmitigation.The Dual Channel Attention(DCA)mechanism improves themodel’s capability to concentrate on the features that aremost appropriate in the input data,which reduces the false favourable rates.The Bidirectional Long,Short-Term Memory framework helps capture crucial interdependence from past and future circumstances,which is essential for enhancing the model’s understanding of malware behaviour.As soon as malware is detected,the risk mitigation phase is implemented,which evaluates the severity of each threat and helps mitigate threats earlier.The outcomes of the method demonstrate better accuracy of 98.96%,which outperforms traditional models.It indicates the method detects and mitigates several kinds of malware threats,thereby providing a proactive defence mechanism against the emerging challenges in cybersecurity.展开更多
Chronic long-segment iliac artery occlusion represents a relatively rare and particularly severe form of iliac artery disease,often associated with complex anatomical challenges.When symptomatic,these patients are typ...Chronic long-segment iliac artery occlusion represents a relatively rare and particularly severe form of iliac artery disease,often associated with complex anatomical challenges.When symptomatic,these patients are typically candidates for surgical revascularization.展开更多
Gastric cancer(GC)is one of the most aggressive malignancies worldwide and is characterized by its poor prognosis and resistance to conventional therapies.Autophagy and long non-coding RNAs(lncRNAs)play critical yet c...Gastric cancer(GC)is one of the most aggressive malignancies worldwide and is characterized by its poor prognosis and resistance to conventional therapies.Autophagy and long non-coding RNAs(lncRNAs)play critical yet complex roles in GC,functioning as both tumor suppressors and promoters depending on the disease stage and context.Autophagy influences cellular homeostasis and metabolism,whereas lncRNAs regulate gene expression through epigenetic modifications,RNA sponging,and protein interactions.Notably,the interplay between lncRNAs and autophagy modulates tumor progression,metastasis,chemoresistance,and the tumor microenvironment.This study explored the intricate relationship between lncRNAs and autophagy in GC,highlighting their roles in pathogenesis and treatment resistance.By addressing current knowledge gaps and proposing innovative therapeutic strategies,we have emphasized the potential of targeting this dynamic interplay for improved diagnostic and therapeutic outcomes.展开更多
文摘AIM: To track the short-term neck narrowing changes in Birmingham metal-on-metal hip resurfacing(MOMHR) patients. METHODS: Since 2001, the Center for Hip and Knee Replacement started a registry to prospectively collect data on hip and knee replacement patients. From June 2006 to October 2008, 139 MOMHR were performed at our center by two participate surgeons using Birmingham MOMHR prosthesis(Smith Nephew, United States). It is standard of care for patients to obtain low, anteriorposterior(LAP) pelvis radiographs immediately after MOMHR procedure and then at 3 mo, 1 year and 2 year follow up office visits. Inclusion criteria for the present study included patients who came back for follow up office visit at above mentioned time points and got LAP radiographs. Exclusion criteria include patients who missed more than two follow up time points and those with poor-quality X-rays. Two orthopaedic residency trained research fellows reviewed the X-rays independently at 4 time points, i.e., immediate after surgery, 3 mo, 1 year and 2 year. Neck-to-prosthesis ratio(NPR) was used as main outcome measure. Twenty cases were used as subjects to identify the reliability between two observers. An intraclass correlation coefficient at 0.8 was considered as satisfied. A paired t-test was used to evaluate the significant difference between different time points with P < 0.05 considered to be statistically significant.RESULTS: The mean NPRs were 0.852 ± 0.056, 0.839 ± 0.052, 0.835 ± 0.051, 0.83 ± 0.04 immediately, 3 mo, 1 year and 2 years post-operatively respectively. At 3 mo, NPR was significantly different from immediate postoperative X-ray(P < 0.001). There was no difference between 3 mo and 1 year(P = 0.14) and 2 years(P = 0.53). Femoral neck narrowing(FNN) exceeding 10% of the diameter of the neck was observed in only 4 patients(5.6%) at two years follow up. None of these patients developed a femoral neck fracture(FNF). CONCLUSION: Femoral neck narrowing after MOMHR occurred as early as 3 mo postoperatively, and stabilized thereafter. Excessive FNN was not common in patients within the first two years of surgery and was not correlated with risk of FNF.
文摘We present here our investigations of the features of focused electron beam transport in free space at elevated pressures of a few pascals.We have explored the effect of the beam accelerating voltage,operating gas pressure,and magnetic focusing upon the trajectory of beam electrons in the crossover region,in particular on the beam convergence and divergence angles.It is shown that for the forevacuum pressure range of 2-5 Pa explored,a distinctive feature of the propagation of a focused electron beam with a current of up to 20 mA at an accelerating voltage of 10-20 kV is the difference in the angles of convergence(before the focus)and divergence(after the focus).Whereas at a low pressure of 2 Pa the divergence angle is smaller than the convergence angle,as the pressure increases the divergence angle increases and for pressures greater than 5 Pa the divergence angle is greater than the convergence angle.The results obtained were used in experiments on electron beam transport through a long narrow metal tube with a diameter of 5.8-9.2 mm and length of 10-30 cm.We show that for a 30 cm long tube of 7.5 mm diameter,the focused beam transmission can exceed 70%.
基金supported by the National Research Foundation of Korea(NRF),funded by the Ministry of Science and ICT(MSIT),Republic of Korea(grant numbers:RS-2022-NR070489 and RS-2023-00210847)the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health and Welfare,Republic of Korea(grant number HR21C1003).
文摘Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome(BAC)clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated.This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC,outlining their genomic origins,molecular mechanisms,and biological significance.We highlight their roles in metabolic reprogramming,microRNA network modulation,and tumor progression,as well as their diagnostic and prognostic value in tissue and serum-based analyses.Finally,we discuss therapeutic opportunities and propose future directions to translate RP11-derived lncRNAs into clinically actionable biomarkers and targets for precision liver cancer therapy.
文摘Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,genetics alone is not the decisive factor-environmental conditions also play a vital role in achieving a long life(Selinus O,2013).
基金support of the National Natural Science Foundation of China(No.22361011)Guizhou Provincial Science and Technology Projects(No.ZK[2023]General 040)the Guizhou Provincial Key Laboratory Platform Project(No.ZSYS[2025]008)。
文摘This investigation focuses on the utilization of cucurbit[6]uril(Q[6])as the host compound for the development of long-lasting afterglow materials.By strategically manipulating the outer surface interactions of Q[6],classical aggregation-caused quenching(ACQ)compounds such as fluorescein sodium(FluNa)and calcein sodium(CalNa)were transformed into afterglow materials with varying colors and durations upon exposure to ultraviolet light.This transformation was facilitated through a host-vip doping method combined with coordination with metal ions.Even at a reduced doping concentration of 5×10^(-5)wt%,the materials exhibit remarkable afterglow properties,lasting up to 2 s,with a phosphorescence lifetime of up to 150 ms.Moreover,by adjusting the concentration of the vip compound,the persistent luminescence color of the materials could be easily transitioned from orange to yellow and subsequently to green.These findings suggest that the developed afterglow materials hold significant potential for multilevel anti-counterfeiting and information encryption applications when exposed to ultraviolet light.The supramolecular assembly strategy,which relies on the outer surface interactions of cucurbit[n]uril,offers a simpler and more efficient approach to crafting multi-color luminescent materials.Additionally,this method opens avenues for enhancing the application potential of aggregation-caused quenching(ACQ)compounds in various technological domains.
基金Supported by National Natural Science Foundation of China,No.82405223Yunling Scholars Program,No.XDYC-YLXZ-2022-0027.
文摘Hepatocellular carcinoma(HCC)is a highly lethal malignancy with limited treatment options,particularly for patients with advanced stages of the disease.Sorafenib,the standard first-line therapy,faces significant challenges due to the development of drug resistance.Yu et al explored the mechanisms by which lncRNA KIF9-AS1 regulates the stemness and sorafenib resistance in HCC using a combination of cell culture,transfection,RNA immunoprecipitation,co-immunoprecipitation,and xenograft tumor models.They demonstrate that N6-methyladenosine-modified long non-coding RNA KIF9-AS1 acts as an oncogene in HCC.This modification involves methyltransferase-like 3 and insulin-like growth factor 2 mRNA-binding protein 1,which play critical roles in regulating KIF9-AS1.Furthermore,KIF9-AS1 stabilizes and upregulates short stature homeobox 2 by promoting its deubiquitination through ubiquitin-specific peptidase 1,thereby enhancing stemness and contributing to sorafenib resistance in HCC cells.These findings provide a theoretical basis for KIF9-AS1 as a diagnostic marker and therapeutic target for HCC,highlighting the need for further investigation into its clinical application potential.
文摘This paper mainly studies the well-posedness of steady incompressible impinging jet flow problem through a 3D axisymmetric finitely long nozzle.This problem originates from the physical phenomena encountered in practical engineering fields,such as in short take-off and vertical landing(STOVL)aircraft.Nowadays many intricate phenomena associated with impinging jet flows remain inadequately elucidated,which limits the ability to optimize aircraft design.Given a boundary condition in the inlet,the impinging jet problem is transformed into a Bernoulli-type free boundary problem according to the stream function.Then the variational method is used to study the corresponding variational problem with one parameter,thereby the wellposedness is established.The main conclusion is as follows.For a 3D axisymmetric finitely long nozzle and an infinitely long vertical wall,given an axial velocity in the inlet of nozzle,there exists a unique smooth incom‑pressible impinging jet flow such that the free boundary initiates smoothly at the endpoint of the nozzle and extends to infinity along the vertical wall at far fields.The key point is to investigate the regularity of the corner where the nozzle and the vertical axis intersect.
文摘Deep learning plays a vital role in real-life applications, for example object identification, human face recognition, speech recognition, biometrics identification, and short and long-term forecasting of data. The main objective of our work is to predict the market performance of the Dhaka Stock Exchange (DSE) on day closing price using different Deep Learning techniques. In this study, we have used the LSTM (Long Short-Term Memory) network to forecast the data of DSE for the convenience of shareholders. We have enforced LSTM networks to train data as well as forecast the future time series that has differentiated with test data. We have computed the Root Mean Square Error (RMSE) value to scrutinize the error between the forecasted value and test data that diminished the error by updating the LSTM networks. As a consequence of the renovation of the network, the LSTM network provides tremendous performance which outperformed the existing works to predict stock market prices.
文摘BACKGROUND Intracranial blister-like microaneurysms are an extremely rare disease.Rupture of intracranial aneurysms can lead to subarachnoid hemorrhage(SAH).Patients with SAH may experience severe neurological symptoms,including severe headache,nausea,vomiting,transient or persistent loss of consciousness,limb weakness,and blurred vision.Ruptured aneurysms should be surgically treated as soon as possible.Intravascular electrocoagulation is becoming a promising treatment method for intracranial blister-like microaneurysms.The short-term follow-up results demonstrated that this method is safe and effective.This article presents a case of endovascular electrocoagulation for the treatment of a blisterlike microaneurysm.CASE SUMMARY This article reports the case of 71-year-old female patient with an intracranial aneurysm.The patient experienced a sudden headache with vomiting for 3 hours.Brain computed tomography(CT)scan showed a subarachnoid hemorrhage.She was diagnosed with rupture of an aneurysm and subarachnoid hemorrhage.The aneurysm was located in the choroidal segment of the right internal carotid artery.The size of the aneurysm was 2.00 mm×1.80 mm×1.97 mm,and the neck of the aneurysm was less than 0.5 mm wide.We successfully treated this aneurysm with endovascular electrocoagulation,and the patient was safely returned to the ward and discharged after subsequent supportive treatment.CT angiography reexamination 3 months after surgery revealed no contrast agent extravasation in the original lesion,with a good prognosis.CONCLUSION Endovascular electrocoagulation is an effective and safe method for the treatment of intracranial blister-like microaneurysms.
基金Project(42277175)supported by the National Natural Science Foundation of ChinaProject(NRMSSHR-2022-Z08)supported by the Key Laboratory of Natural Resources Monitoring and Supervision in Southern Hilly Region,Ministry of Natural Resources,China。
文摘Narrow backfill earth pressure estimation is applied to study the stability of supporting structures in the vicinity of existing buildings.Previous narrow backfill earth pressure studies have neglected seismic-unsaturated seepage multi-field coupling,resulting in inaccurate estimates.To address these deficiencies,this paper proposed a calculation method for seismic passive earth pressure in unsaturated narrow backfill,based on inclined thin-layer units.It considers the interlayer shear stress,arching effect,and the multi-field coupling of seismic-unsaturated seepage.Additionally,this paper includes a parametric sensitivity analysis.The outcomes indicate that the earthquake passive ground pressure of unsaturated narrow backfill can be reduced by increasing the aspect ratio,seismic acceleration coefficient,and unsaturation parameterα.It can also be reduced by decreasing the effective interior friction angle,soil cohesion,wallearth friction angle,and vertical discharge.Furthermore,for any width soil,lowering the elevation of the action point of passive thrust can be attained by raising the effective interior friction angle,wall-earth friction angle,and unsaturation parameterα.Reducing soil cohesion,seismic acceleration coefficient,and vertical discharge can also lower the height of the application point of passive thrust.
基金financially supported by the National Key Research and Development Program of China(2022YFE0110300)the National Natural Science Foundation of China(52261145696 and 52473187)+1 种基金the“111”Projectthe Collaborative Innovation Center of Suzhou Nano Science and Technology,Soochow University。
文摘Organic-inorganic hybrid solar cells consisting of organic conjugated materials and inorganic quantum dots(QDs)have been of great interest during the past two decades.However,it is still challenging to select desired organic functional materials for fabricating hybrid films to maximize their photovoltaic performance.Herein,we report the synthesis of three narrow bandgap non-fullerene conjugated polymers and further demonstrate the importance and impact of polymer crystallinity in tuning the organic-inorganic hybrid interface towards improved photovoltaic performance.In specific,we develop an organic-inorganic hybrid active layer using a newly synthesized polymer with relatively weaker crystallinity and FAPbI_(3)QDs,enabling complementary absorption and favorable interface/morphology for efficient charge separation and transport.The champion PCDOT-T/FAPbI_(3)QD hybrid device achieves a record-high efficiency of 13.11%based on the one-step coating organic/QD hybrid bulk heterojunction blend,which is significantly improved relative to the semi-crystalline polymer PYIT-based hybrid device(11.23%)and pristine QD(10.51%).We believe these findings would provide new insight into the organic/QD interface to construct desired hybrid films for high-performing optoelectronic applications.
文摘Background:Over 65 million people have long COVID.Evidence for using Chinese herbal medicine(CHM)to treat long COVID is growing.A systematic review of evidence for guiding clinical decision is warranted.Objective:To examine the effects and safety of CHM in alleviating the severity of dyspnea,fatigue,exercise intolerance,depression,anxiety and insomnia in long COVID adults based on registered randomized clinical trials(RCT).Search strategy:World Health Organization International Clinical Trials Registry Platform and Chinese Clinical Trial Registry were searched for registered trial protocols from database inception to February 10,2023.English(PubM ed,Embase,AMED and CINAHL)and Chinese databases(CNKI,Wanfang Data and CQVIP)were then searched to identify relevant publications from December 2019 through April 6,2023.Inclusion criteria:Registered RCTs that compared the effects of Chinese herbal medicines or Chinese herbal formulas against a control treatment(i.e.,the placebo or usual care)in adults with persistent symptoms of long COVID.The primary outcome of dyspnea,and secondary outcomes of fatigue,exercise intolerance,depression,anxiety and insomnia were measured using validated tools at the end of the treatment.Data extraction and analysis:Data were extracted,and eligible RCTs were evaluated using version 2 of the Cochrane risk-of-bias tool for randomized trials and Grading of Recommendations,Assessment,Development and Evaluations independently by two researchers.Effect sizes were estimated by randomeffects modelling and mean difference(MD).Heterogeneity between trials was quantified by I^(2).Results:Among the 38 registered clinical trials we identified,seven RCTs(1,519 patients)were included in the systematic review.One RCT had a low overall risk of bias.Compared to the control,CHM reduces dyspnea on the Borg Dyspnea Scale score(MD=–0.2,95%confidence interval[CI]=–0.65 to 0.25)with moderate certainty,and reduces fatigue on the Borg Scale(MD=–0.48,95%CI=–0.74 to–0.22)with low certainty.CHM clinically reduces depression on Hamilton Depression Rating Scale score(MD=–6.00,95%CI=–7.56 to–4.44)and anxiety on Hamilton Anxiety Rating Scale score(MD=–6.10,95%CI=–7.67 to–4.53),and reduces insomnia on the Insomnia Severity Index(MD=–4.86,95%CI=–12.50 to 2.79)with moderate certainty.Meta-analysis of two RCTs(517 patients)showed that CHM clinically improves exercise intolerance by increasing 6-minute walking distance(MD=–15.92,95%CI=–10.20 to 42.05)with substantial heterogeneity(I^(2)=68%)and low certainty.Conclusion:CHM is associated with a post-treatment clinical reduction in depression and anxiety in long COVID adults,compared to the control,but it does not have a strong treatment effect on dyspnea and insomnia.Effects of CHM on exercise intolerance and fatigue are uncertain,and the safety of using CHM remains questionable.
基金co-supported by the National Natural Science Foundation of China(Nos.52376138 and 52025064)the Science Center for Gas Turbine Project,China(No.P2022B-Ⅱ-018-001)the Foundation Research Project,China(No.1002TJA22010)。
文摘The reignition of aero-engine combustors at high altitudes poses significant challenges due to the low-temperature and low-pressure environment.A novel Long Pulse-Width Plasma Ignition(LPWPI)system has been developed to enhance ignition performance.The LPWPI system can effectively prolong the discharge duration time,improve ignition efficacy,and increase the plasma penetration depth.Experimental comparisons with the traditional Spark Ignition(SI)system demonstrate that the LPWPI increased discharge duration to 2.03 ms,which is 45 times longer than that of the SI system,while also doubling the spark penetration depth to 24.1 mm.The LPWPI system achieved a discharge efficiency of 61.1%,significantly surpassing the SI system's efficiency of23.3%.These advancements facilitated an extension of the lean ignition boundary by approximately 22.7%to 39.3%.High-speed camera recordings reveal that the spark duration of the LPWPI system was extended to 2.1 ms,compared to 0.6 ms in the SI system.Ignition progress with LPWPI shows a sustained spark kernel without the flame residence stage observed in the SI system.The impressive performance of the LPWPI system suggests that it is a promising alternative for aero-engine ignition systems.
文摘The published article titled“Overexpression of long noncoding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells”has been retracted from Oncology Research,Vol.26,No.6,2018,pp.869–878.
文摘The published article titled“Long Noncoding RNA SChLAP1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Targeting miR-198 and Promoting the MAPK1 Pathway”has been retracted from Oncology Research,Vol.26,No.1,2018,pp.131–143.
基金supported by the China Agriculture Research System of MOF and MARA(CARS-04-PS12)the Research and Development Program in the Key-Areas of Guangdong Province,China(2020B020220008)the Guangdong Agricultural Research System,China(2023KJ136-03).
文摘Soybean seed isoflavones are a type of secondary metabolites that can provide health and nutrition benefits for humans. In our previous study, a stable quantitative trait locus(QTL) qIF05-1 controlling the seed isoflavone content in soybean was detected on chromosome(Chr.) 05 in a recombinant inbred line(RIL) population from a cross of Huachun 2×Wayao. In this study, the parental lines were re-sequenced using the Illumina Solexa System with deep coverage. A total of 63,099 polymorphic long insertions and deletions(InDels)(≥15 bp)were identified between the parents Huachun 2 and Wayao. The InDels were unevenly distributed on 20chromosomes of soybean, varying from 1,826 in Chr. 12 to 4,544 in Chr. 18. A total of 10,002 long InDels(15.85% of total) were located in genic regions, including 1,139 large-effect long InDels which resulted in truncated or elongated protein sequences. In the qIF05-1 region, 68 long InDels were detected between the two parents. Using a progeny recombination experiment and genotype analysis, the qIF05-1 locus was mapped into a 102.2 kb genomic region, and this region contained 12 genes. By RNA-seq data analysis, genome sequence comparison and functional validation through ectopic expression in Arabidopsis thaliana, Glyma.05G208300(described as GmEGL3), which is a basic helix-loop-helix(bHLH) transcription factor in plants, emerged as the most likely confirmed gene in qIF05-1. These long InDels can be used as a type of complementary genetic method for QTL fine mapping, and they can facilitate genetic studies and molecular-assisted selection breeding in soybean.
基金funded by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant No.(IPP:421-611-2025).
文摘Over the past few years,Malware attacks have become more and more widespread,posing threats to digital assets throughout the world.Although numerous methods have been developed to detect malicious attacks,these malware detection techniques need to be more efficient in detecting new and progressively sophisticated variants of malware.Therefore,the development of more advanced and accurate techniques is necessary for malware detection.This paper introduces a comprehensive Dual-Channel Attention Deep Bidirectional Long Short-Term Memory(DCADBiLSTM)model for malware detection and riskmitigation.The Dual Channel Attention(DCA)mechanism improves themodel’s capability to concentrate on the features that aremost appropriate in the input data,which reduces the false favourable rates.The Bidirectional Long,Short-Term Memory framework helps capture crucial interdependence from past and future circumstances,which is essential for enhancing the model’s understanding of malware behaviour.As soon as malware is detected,the risk mitigation phase is implemented,which evaluates the severity of each threat and helps mitigate threats earlier.The outcomes of the method demonstrate better accuracy of 98.96%,which outperforms traditional models.It indicates the method detects and mitigates several kinds of malware threats,thereby providing a proactive defence mechanism against the emerging challenges in cybersecurity.
文摘Chronic long-segment iliac artery occlusion represents a relatively rare and particularly severe form of iliac artery disease,often associated with complex anatomical challenges.When symptomatic,these patients are typically candidates for surgical revascularization.
文摘Gastric cancer(GC)is one of the most aggressive malignancies worldwide and is characterized by its poor prognosis and resistance to conventional therapies.Autophagy and long non-coding RNAs(lncRNAs)play critical yet complex roles in GC,functioning as both tumor suppressors and promoters depending on the disease stage and context.Autophagy influences cellular homeostasis and metabolism,whereas lncRNAs regulate gene expression through epigenetic modifications,RNA sponging,and protein interactions.Notably,the interplay between lncRNAs and autophagy modulates tumor progression,metastasis,chemoresistance,and the tumor microenvironment.This study explored the intricate relationship between lncRNAs and autophagy in GC,highlighting their roles in pathogenesis and treatment resistance.By addressing current knowledge gaps and proposing innovative therapeutic strategies,we have emphasized the potential of targeting this dynamic interplay for improved diagnostic and therapeutic outcomes.
