Rare earth luminescent materials have attracted extensive attention in the biomedical field as noncontact temperature monitoring devices with microscopic resolution due to their properties in the visible and near-infr...Rare earth luminescent materials have attracted extensive attention in the biomedical field as noncontact temperature monitoring devices with microscopic resolution due to their properties in the visible and near-infrared regions.At the application level,it is required to have a certain temperature monitoring capability in the near-infrared region II window to enhance the tissue penetration depth.Here,two kinds of YOFs:Er^(3+),Yb^(3+)were prepared by co-precipitation and hydrothermal method,and the luminescence was enhanced by ion doping.An Er^(3+)-based ratiometric nanothermometer of ^(4)F_(9∕2)→4 I_(15∕2)(672nm,upconversion luminescence)to ^(4)I _(13∕2)→^(4) I_(15∕2)(1580nm/1566nm,NIR II downshifting luminescence)were designed with the Stark energy level.When doped with 2%Zn^(2+),the relative temperature sensitivity of YOF prepared by co-precipitation method was improved from 0.30%℃^(-1)(30℃)to 0.59%℃^(-1)(30℃),expanding its use as a temperature monitoring device possibility.The temperature sensitivity of YOF prepared by hydrothermal method was 1.01%℃^(-1)(30℃).Finally,the NIR II luminescence of the prepared nanothermometer was used as a control for temperature monitoring of heating sites in mice.The results showed that it can distinguish heating site from control site and no significant cytotoxicity or damage to the tissues was revealed,indicating its broad prospects in the biomedical field and other temperature monitoring scenarios in the future.展开更多
Electromechanical carbon nanothermometers are devices that work based on the interactions and relative mo- tions of double-walled carbon nanotubes （DWCNTs）. In this paper, the mechanics of carbon nanotubes （CNTs） ...Electromechanical carbon nanothermometers are devices that work based on the interactions and relative mo- tions of double-walled carbon nanotubes （DWCNTs）. In this paper, the mechanics of carbon nanotubes （CNTs） con- stituting two welt-known configurations for nanothermome- ter, namely shuttle configuration and telescope configuration are fully investigated. Lennard-Jones （LJ） potential func- tion along with the continuum approximation is employed to investigate van der Waals （vdW） interactions between the in- teracting entities. Accordingly, semi-analytical expressions in terms of single integrals are obtained for vdW interactions. Acceptance condition and suction energy are studied for the shuttle configuration. In addition, a universal potential en- ergy is presented for the shuttle configuration consisting of two finite CNTs. Also, for the telescope configuration, ex- tensive studies are performed on the distributions of potential energy and interaction force for various radii and lengths of CNTs. It is found that these geometrical parameters have a considerable effect on the potential energy.展开更多
Fluorescent nanothermometers for remote temperature measurement at the micro/nanoscale have stimulated growing efforts in developing efficient temperature-responsive materials and detection procedures.However,the effi...Fluorescent nanothermometers for remote temperature measurement at the micro/nanoscale have stimulated growing efforts in developing efficient temperature-responsive materials and detection procedures.However,the efficient collection and transmission of optical signals have been a tremendous challenge for practical applications of these nanothermometers.Herein,we design an all-fiberized thermometry based on a fiber-coupled microsphere cavity coated with thermo-sensitive NaYF_(4)∶20%Yb^(3+);2%Er^(3+)@NaYF_(4)nanocrystals(NCs),allowing for spatial temperature sensing with resolution down to the few-micrometer scale.In our design,the microsphere efficiently excites the NCs and collects their upconversion emissions,and the use of a fiber splitter coupled with the microsphere allows for lossless routing of excitation and emitted light.We demonstrate the use of this all-fiber temperature sensor in diverse environments,especially in strongly acidic and alkaline conditions.Leveraging the high flexibility of commercial silica fiber,this all-fiber temperature ensor was employed for stable fixed-point real-time temperature measurement and multipurpose temperature recording/mapping in opaque environments,microscale areas,various solutions,and complicated bent structures.Thus,the demonstrated design could have strong implications for the practical use of nanothermometers in various possible scenarios,especially monitoring temperatures in diverse physiological settings.展开更多
Temperature measurement in biology and medical diagnostics, along with sensitive temperature probing in living cells, is of great importance; however, it still faces significant challenges. Metal nanoclusters （NCs） ...Temperature measurement in biology and medical diagnostics, along with sensitive temperature probing in living cells, is of great importance; however, it still faces significant challenges. Metal nanoclusters （NCs） with attractive luminescent properties may be promising candidates to overcome such challenges. Here, a novel one-step synthetic method is presented to prepare highly fluorescent copper NCs （CuNCs） in ambient conditions by using glutathione （GSH） as both the reducing agent and the protective layer preventing the aggregation of the as-formed NCs. The resultant CuNCs, with an average diameter of 2.3 nm, contain 1-3 atoms and exhibit red fluorescence （A^m = 610 nm） with high quantum yields （QYs, up to 5.0%）. Interestingly, the fluorescence signal of the CuNCs is reversibly responsive to the environmental temperature in the range of 15-80 ℃. Furthermore, as the CuNCs exhibit good biocompatibility, they can pervade the MC3T3-E1 cells and enable measurements over the physiological temperature range of 15-45 ℃ with the use of the confocal fluorescence imaging method. In view of the facile synthesis method and attractive fluorescence properties, the as-prepared CuNCs may be used as photoluminescence thermometers and biosensors.展开更多
基金supported by the Key Research and Development Program of Shaanxi(Program No.2023-YBSF-479)the National Natural Science Foundation of China(NSFC 22075249)the Fundamental Research Funds for the Central Universities.
文摘Rare earth luminescent materials have attracted extensive attention in the biomedical field as noncontact temperature monitoring devices with microscopic resolution due to their properties in the visible and near-infrared regions.At the application level,it is required to have a certain temperature monitoring capability in the near-infrared region II window to enhance the tissue penetration depth.Here,two kinds of YOFs:Er^(3+),Yb^(3+)were prepared by co-precipitation and hydrothermal method,and the luminescence was enhanced by ion doping.An Er^(3+)-based ratiometric nanothermometer of ^(4)F_(9∕2)→4 I_(15∕2)(672nm,upconversion luminescence)to ^(4)I _(13∕2)→^(4) I_(15∕2)(1580nm/1566nm,NIR II downshifting luminescence)were designed with the Stark energy level.When doped with 2%Zn^(2+),the relative temperature sensitivity of YOF prepared by co-precipitation method was improved from 0.30%℃^(-1)(30℃)to 0.59%℃^(-1)(30℃),expanding its use as a temperature monitoring device possibility.The temperature sensitivity of YOF prepared by hydrothermal method was 1.01%℃^(-1)(30℃).Finally,the NIR II luminescence of the prepared nanothermometer was used as a control for temperature monitoring of heating sites in mice.The results showed that it can distinguish heating site from control site and no significant cytotoxicity or damage to the tissues was revealed,indicating its broad prospects in the biomedical field and other temperature monitoring scenarios in the future.
文摘Electromechanical carbon nanothermometers are devices that work based on the interactions and relative mo- tions of double-walled carbon nanotubes （DWCNTs）. In this paper, the mechanics of carbon nanotubes （CNTs） con- stituting two welt-known configurations for nanothermome- ter, namely shuttle configuration and telescope configuration are fully investigated. Lennard-Jones （LJ） potential func- tion along with the continuum approximation is employed to investigate van der Waals （vdW） interactions between the in- teracting entities. Accordingly, semi-analytical expressions in terms of single integrals are obtained for vdW interactions. Acceptance condition and suction energy are studied for the shuttle configuration. In addition, a universal potential en- ergy is presented for the shuttle configuration consisting of two finite CNTs. Also, for the telescope configuration, ex- tensive studies are performed on the distributions of potential energy and interaction force for various radii and lengths of CNTs. It is found that these geometrical parameters have a considerable effect on the potential energy.
基金supported by the National Natural Science Foundation of China(Grant Nos.52202004,62122027,12204179,62205109,and 62075063)the Key R&D Program of Guangzhou(Grant No.202007020003)+4 种基金the fellowship of China Postdoctoral Science Foundation(Grant Nos.2021M691054 and 2022M711185)the Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2021A1515110475,2021A1515110911,2022A1515011289,and 2023A1515012666)the Guangzhou Basic and Applied Basic Research Foundation(Grant Nos.202201010428 and 202201010407)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(Grant No.2017BT01X137)the State Key Lab of Luminescent Materials and Devices,South China University of Technology.
文摘Fluorescent nanothermometers for remote temperature measurement at the micro/nanoscale have stimulated growing efforts in developing efficient temperature-responsive materials and detection procedures.However,the efficient collection and transmission of optical signals have been a tremendous challenge for practical applications of these nanothermometers.Herein,we design an all-fiberized thermometry based on a fiber-coupled microsphere cavity coated with thermo-sensitive NaYF_(4)∶20%Yb^(3+);2%Er^(3+)@NaYF_(4)nanocrystals(NCs),allowing for spatial temperature sensing with resolution down to the few-micrometer scale.In our design,the microsphere efficiently excites the NCs and collects their upconversion emissions,and the use of a fiber splitter coupled with the microsphere allows for lossless routing of excitation and emitted light.We demonstrate the use of this all-fiber temperature sensor in diverse environments,especially in strongly acidic and alkaline conditions.Leveraging the high flexibility of commercial silica fiber,this all-fiber temperature ensor was employed for stable fixed-point real-time temperature measurement and multipurpose temperature recording/mapping in opaque environments,microscale areas,various solutions,and complicated bent structures.Thus,the demonstrated design could have strong implications for the practical use of nanothermometers in various possible scenarios,especially monitoring temperatures in diverse physiological settings.
基金This work was supported by National Natural Science Foundation of China （Nos. 51372265 and 21175060）, the Natural Science Foundation of Jiangsu Province, China （No. BK20140392）, the Open Foundation of State Key Laboratory of Materials-Oriented Chemical Engineering of Nanjing University of Technology （2014, KL14-12）, the Postdoctoral Research Foundation of Jiangsu Province, China （No. 1401058B）, and the Science and Technology Project of Suzhou, China （Nos~ ZXG201428 and ZXG201401）~
文摘Temperature measurement in biology and medical diagnostics, along with sensitive temperature probing in living cells, is of great importance; however, it still faces significant challenges. Metal nanoclusters （NCs） with attractive luminescent properties may be promising candidates to overcome such challenges. Here, a novel one-step synthetic method is presented to prepare highly fluorescent copper NCs （CuNCs） in ambient conditions by using glutathione （GSH） as both the reducing agent and the protective layer preventing the aggregation of the as-formed NCs. The resultant CuNCs, with an average diameter of 2.3 nm, contain 1-3 atoms and exhibit red fluorescence （A^m = 610 nm） with high quantum yields （QYs, up to 5.0%）. Interestingly, the fluorescence signal of the CuNCs is reversibly responsive to the environmental temperature in the range of 15-80 ℃. Furthermore, as the CuNCs exhibit good biocompatibility, they can pervade the MC3T3-E1 cells and enable measurements over the physiological temperature range of 15-45 ℃ with the use of the confocal fluorescence imaging method. In view of the facile synthesis method and attractive fluorescence properties, the as-prepared CuNCs may be used as photoluminescence thermometers and biosensors.
