Repolarizing tumor-associated macrophages(TAMs)toward the proinflammatory M1 phenotype represents a promising strategy to reverse the immunosuppressive tumor microenvironment(TME)and enhance antitumor immunotherapy.Re...Repolarizing tumor-associated macrophages(TAMs)toward the proinflammatory M1 phenotype represents a promising strategy to reverse the immunosuppressive tumor microenvironment(TME)and enhance antitumor immunotherapy.Recent studies have demonstrated that exogenous electrical stimulation can effectively repolarize TAMs toward the M1 phenotype.However,conventional electrical stimulation methods,relying on invasive implanted electrodes,are restricted to targeting localized tumor regions and pose inherent risks to patients.Notably,biological neural networks,distributed systems of interconnected neurons,can naturally permeate tissues and orchestrate cellular activities with high spatial efficiency.Inspired by this natural system,we developed a global in situ electric field network using piezoelectric BaTiO_(3)nanoparticles.Upon ultrasound stimulation,the nanoparticles generate a wireless electric field throughout the TME.In addtion,their nanoscale size enables them to function as synthetic“neurons”,allowing for uniform penetration throughout the tumor tissue and inducing significant repolarization of TAMs via the Ca^(2+)influx-activated nuclear factor-kappa B(NF-κB)signaling pathway.The repolarized M1 TAMs restore anti-tumor immunostimulatory functions and secrete key proinflammatory cytokines(e.g.,tumor necrosis factor-alpha(TNF-α)and interleukin-1 beta(IL-1β)),which enhance immunostimulation within the TME and directly contribute to tumor cell elimination.Remarkably,this strategy achieved robust in vivo tumor growth inhibition with excellent biosafety in a 4T1 breast tumor model.Overall,this work establishes a non-invasive,wireless electric field platform capable of globally repolarizing TAMs,offering a safe and efficient strategy to advance cancer immunotherapy and accelerate the clinical translation of bioelectronic therapies.展开更多
Changes in solution chemistry and transport conditions can lead to the release of deposited MnO2 nanoparticles from a solid interface,allowing them to re-enter the aqueous environment.Understanding the release behavio...Changes in solution chemistry and transport conditions can lead to the release of deposited MnO2 nanoparticles from a solid interface,allowing them to re-enter the aqueous environment.Understanding the release behavior of Mn02 nanoparticles from naturally occurring surfaces is critical for better prediction of the transport potential and environmental fate of Mn02 nanoparticles.In this study,the release of Mn02 nanoparticles was investigated using a quartz crystal microbalance with dissipation monitoring(QCM-D),and different environmental surface types,solution pH values and representative macromolecular organics were considered.Mn02 nanoparticles were first deposited on crystal sensors at elevated NaN03 concentrations before being rinsed with double-deionized water to induce their remobilization.The results reveal that the release rate of Mn02 depends on the surface type,in the decreasing order:SiO2>Fe304>Al2 O3,resulting from electrostatic interactions between the surface and particles.Moreover,differences in solution pH can lead to variance in the release behavior of Mn02 nanoparticles.The release rate from surfaces was significantly higher at pH 9.8 that at 4.5,indicating that alkaline conditions were more favorable for the mobilization of Mn02 in the aquatic environment.In the presence of macromolecular organics,bovine serum albumin(BSA)can inhibit the release of Mn02 from the surfaces due to attractive forces.In presence of humic acid(HA)and sodium alginate(SA),the Mn02 nanoparticles were more likely to be mobile,which may be associated with a large repulsive barrier imparted by steric effects.展开更多
Entomopathogenic viruses,such as baculoviruses and cypoviruses,have been employed as biological pesticides against agricultural and forestry pests.However,their susceptibility to inactivation under field UV radiation ...Entomopathogenic viruses,such as baculoviruses and cypoviruses,have been employed as biological pesticides against agricultural and forestry pests.However,their susceptibility to inactivation under field UV radiation has hindered their broader application.In this study,we effectively improved the UV resistance of insect virus occlusion bodies(OBs)by coating their surfaces with silica nanoparticles(SiO_(2)NPs).Monodisperse SiO_(2)NPs with uniform size distribution and excellent colloidal stability were synthesized using the Stober method.Subsequent amination modification of the SiO_(2)NPs with a silane coupling agent shifted their isoelectric point from 3.2 to 8.1.This modification imparted a strong positive charge to the NPs within the pH range of 4.5-5.5,while the OBs of insect viruses remained negatively charged in this range.Consequently,the amino-functionalized SiO_(2)NPs were successfully coated onto the surfaces of OBs of three representative insect viruses:nucleopolyhedrovirus,granulovirus,and cypovirus,through electrostatic interactions.Laboratory bioassays confirmed that Mamestra brassicae multiple nucleopolyhedrovirus(MbMNPV)coated with SiO_(2)-NH2 NPs retained its native viral pathogenicity against Spodoptera exigua larvae under normal laboratory condition,while it demonstrated 2.299-2.712 folds higher potency than MbMNPV physically mixed with unmodified SiO_(2)NPs after UV irradiation.Outdoor trials revealed that SiO_(2)-NH_(2)NPs coating significantly improved the survival time of MbMNPV,with the median survival time increased from 1.43 days to 5.15 days.This nanoparticle coating strategy establishes a robust platform for developing photostable biopesticides while preserving their ecological safety profiles.The modular nature of this approach suggests its broad applicability across different entomopathogenic virus formulations.展开更多
Wound healing remains a critical challenge in medical treatment,particularly for infected and complex wounds.This study introduces a novel spray able nanocomposite hydrogel dressing(SA/CaCl_(2)/CeO_(2),SCC)that demons...Wound healing remains a critical challenge in medical treatment,particularly for infected and complex wounds.This study introduces a novel spray able nanocomposite hydrogel dressing(SA/CaCl_(2)/CeO_(2),SCC)that demonstrates exceptional potential for accelerated wound healing and bacterial infection control.By integrating cerium oxide nanoparticles(CeO_(2)NPs)with sodium alginate(SA)and calcium chloride(CaCl_(2)),we developed a versatile and portable wound healing solution that possesses the ability to scavenge reactive oxygen species(ROS),remarkable biocompatibility,antibacterial properties,and regenerative capabilities.The synthesized SCC hydrogel was comprehensively characterized through advanced microscopic and spectroscopic techniques,revealing a unique nanostructured composition with intrinsic redox capacity.In vitro assessments demonstrated excellent cytocompatibility,hemocompatibility,and potent antibacterial activity against both gram-positive and gramnegative bacteria.In vivo rat wound model experiments further validated the hydrogel's therapeutic efficacy,showing significantly accelerated wound closure,reduced inflammatory responses,and enhanced tissue regeneration.Key innovations include the hydrothermal synthesis of CeO_(2)nanoparticles,a simple spray-induced crosslinking process,and the strategic incorporation of nanoparticles to modulate wound healing mechanisms.The SCC hydrogel exhibited superior performance in promoting granulation tissue formation,collagen deposition,and bacterial elimination,positioning it as a promising candidate for advanced wound management strategies.展开更多
In this paper,polyamide(PA)woven fabric was used as the base fabric,and polyurethane(PU)solution containing silica nanoparticles(PU@SiO_(2)NPs)was used as the coating solution to prepare composite tent fabric(PA/PU@Si...In this paper,polyamide(PA)woven fabric was used as the base fabric,and polyurethane(PU)solution containing silica nanoparticles(PU@SiO_(2)NPs)was used as the coating solution to prepare composite tent fabric(PA/PU@SiO_(2)).The morphology,structure,and durability of the tent fabric under ultraviolet(UV)radiation,waterstained,or thermal conditions were investigated.The results show that compared with PA/PU fabric without SiO_(2)NPs,when the mass fraction of SiO_(2)NPs in PU coating is 5%,the air permeability of PA/PU@SiO_(2)fabric decreases from about 7.5 to 6.0 nm/s,while the reflectivity to UVvisible light is significantly improved.The surface wettability decreases,as indicated by the average water contact angle(WCA)on PA/PU@SiO_(2)remaining stable at 47°after 9 min.After thermal treatment,the PA/PU@SiO_(2)fabric shows superior mechanical stability.The degradation rate of the tensile strength is only 6.3%,approximately half that of the PA/PU fabric.Meanwhile,the elongation at break increases to 98.9%,compared to 61.8%for the PA/PU fabric.展开更多
As a typical reactive composite hydrogen storage system,2LiBH_(4)-MgH_(2)holds an ultrahigh hydrogen storage capacity of 11.5 wt%.However,it suffers from sluggish hydrogen storage kinetics due to the difficult nucleat...As a typical reactive composite hydrogen storage system,2LiBH_(4)-MgH_(2)holds an ultrahigh hydrogen storage capacity of 11.5 wt%.However,it suffers from sluggish hydrogen storage kinetics due to the difficult nucleation of MgB_(2).Herein,amorphous VB_(2)nanoparticles with an average size of approximately 32 nm are synthesized to enhance the hydrogen storage performance of 2LiBH_(4)-MgH_(2)composite.VB_(2),sharing the same hexagonal structure with MgB_(2)with a d-value mismatch ratio of only 2.28%,could serve as effective nucleation sites for promoting the formation of MgB_(2).Theoretical calculations reveal that the introduction of VB_(2)significantly reduces the binding energies of B and Mg,facilitating in situ nucleation of MgB_(2).As a result,after the introduction of VB_(2)nanoparticles,complete hydrogen desorption of 9.23 wt%is achieved for 2LiBH_(4)-MgH_(2)within 2 h at 400℃,which is 4 times shorter than the time required for pure 2LiBH_(4)-MgH_(2),and no nucleation incubation period for hydrogen desorption is observed even at a low temperature of380℃.More importantly,a reversible capacity of9.3 wt%,corresponding to a capacity retention of 100%,could be preserved after 10 cycles of hydrogen storage,demonstrating stable reversible hydrogen storage performance.This study provides a novel technological pathway for improving the reversible hydrogen storage performance of composite metal hydrides and offers significant insights into the development of high-performance hydrogen storage materials.展开更多
Pure TiO_(2)and copper-modified titania(Cu/TiO_(2))nanoparticles were synthesized through sol gel combined with the pyrolysis method for the removal of Congo red(CR)in wastewater treatment.Surface morphology and struc...Pure TiO_(2)and copper-modified titania(Cu/TiO_(2))nanoparticles were synthesized through sol gel combined with the pyrolysis method for the removal of Congo red(CR)in wastewater treatment.Surface morphology and structural evaluation utilized XRD,TEM,Raman,FTIR and BET techniques.Cu/TiO_(2)showed rich defects and a higher specific surface area than that of TiO_(2).The 1Cu/TiO_(2)(molar ratio Cu/TiO_(2)of 1/100)showed the best performance to adsorption of CR solution at different reaction conditions(contact duration,CR concentration,adsorbent dose,temperature,and initial pH).Adsorption kinetics and equilibrium isotherms were well-described with a pseudo-second-order kinetics and Freundlich model,respectively.The negative ΔG indicates stable adsorption of CR on the Cu/TiO_(2)surface.The adsorption efficiency only decreases by 6%after 5 cycles of adsorption regeneration.The successful synthesis of Cu/TiO_(2)offers a new possibility to address the problems related to CR dye from aqueous solutions.展开更多
Water electrolysis to produce hydrogen has broad prospects due to its pollution-free feature,yet its electrolysis efficiency is limited by the slow kinetics of the anodic oxygen evolution reaction(OER).In this study,w...Water electrolysis to produce hydrogen has broad prospects due to its pollution-free feature,yet its electrolysis efficiency is limited by the slow kinetics of the anodic oxygen evolution reaction(OER).In this study,we develop a synergistic catalyst which integrates MXene/TiO_(2)-supported Ru nanoparticles and oxygen-coordinated Co single atoms(RuCo-MXene/TiO_(2))for efficient OER.This double-tuned structure enables both high-density active sites and precise microenvironment control.Moreover,the interaction between metals during annealing process provides the generation of metallic-bonded Ru-Co pairs between Ru nanoparticles and Co single atoms,facilitating Ru nanoparticles-to-support charge transfer,resulting in optimized electronic properties of the catalyst.As expected,the as-synthesized RuCo-MXene/TiO_(2) catalyst at 10 mA·cm^(-2) current density exhibits 208 mV low overportential and a longterm stability of up to 500 h,which is superior to Ru-MXene/TiO_(2) and Co-MXene/TiO_(2).This work provides a promising strategy for designing efficient and stable electrocatalysts for renewable energy applications.展开更多
The p-block metal(In,Sn,Bi,etc.)-based electrocatalysts have exhibited excellent activity in the electrocatalytic CO_(2)reduction(ECR)to formate.However,the rapid decrease in catalytic activity caused by catalyst reco...The p-block metal(In,Sn,Bi,etc.)-based electrocatalysts have exhibited excellent activity in the electrocatalytic CO_(2)reduction(ECR)to formate.However,the rapid decrease in catalytic activity caused by catalyst reconstruction and agglomeration under ECR conditions significantly restricts their practical applications.Herein,we developed a sulfur anchoring strategy to stabilize the high-density sub-3 nm In_(2)S_(3)nanoparticles on sulfur-doped porous carbon substrates(i-In_(2)S_(3)/S-C)for formate production.Systematic characterizations evidenced that the as-prepared catalyst exhibited a strong metal sulfide-support interaction(MSSI),which effectively regulated the electronic states of In_(2)S_(3),achieving a high formate Faradaic efficiency of 91%at−0.95 V vs.RHE.More importantly,the sulfur anchoring effectively immobilized the sub-3 nm In_(2)S_(3)nanoparticles to prevent them from agglomeration.It enabled the catalysts to exhibit much higher durability than the In_(2)S_(3)samples without sulfur anchoring,demonstrating that the strong MSSI and fast charge transfer on the catalytic interface could significantly promote the structural stability of In_(2)S_(3)catalysts.These results provide a viable approach for developing efficient and stable electrocatalysts for CO_(2)reduction.展开更多
Gemcitabine(Gem)is the gold-standard chemotherapeutic drug for pancreatic cancer therapy in clinic.However,intratumoral bacteria can metabolize Gem into an inactive form,leading to Gem resistance.To address this chall...Gemcitabine(Gem)is the gold-standard chemotherapeutic drug for pancreatic cancer therapy in clinic.However,intratumoral bacteria can metabolize Gem into an inactive form,leading to Gem resistance.To address this challenge,Zn^(2+)-containing nanoparticles(ZGP NPs)are used to eliminate intracellular bacteria to enhance the therapeutic efficacy of Gem in pancreatic therapy.ZGP NPs are prepared via a facile one-pot method using Zn2+,epigallocatechin gallate(EGCG),and polyethylene glycol(PEG),which prevents metal ion chelation by proteins and ensures antibacterial activity.Leveraging the pH-responsive disassembly of metal-phenolic networks,ZGP NPs can be degraded in acidic lysosomes after cellular uptake,releasing Zn^(2+)to eliminate intracellular bacteria and thereby protecting Gem from bacteria-mediated inactivation.Moreover,the elimination of intratumoral bacteria enhances immunotherapy.The delivery of Zn^(2+)via ZGP NPs presents a promising strategy to eliminate intratumoral bacteria to overcome Gem resistance in pancreatic cancer therapy.展开更多
In this study,the corrosion resistance and the stability of passive films on the laser melting depositionprocessed 316L austenitic stainless steel with varying CeO_(2)contents in the environment of proton exchange mem...In this study,the corrosion resistance and the stability of passive films on the laser melting depositionprocessed 316L austenitic stainless steel with varying CeO_(2)contents in the environment of proton exchange membrane fuel cells were investigated using a combination of electrochemical and microstructural analyses.The findings reveal that 316L austenitic stainless steel with 0.20 wt%CeO_(2)exhibits a superior corrosion resistance,primarily due to grain refinement,a high proportion of low-angle grain boundaries and low∑coincidence site lattice grain boundaries,as well as increased dislocation density.The addition of CeO_(2)optimizes the type and size of inclusions and exerts a drag effect on grain boundaries,promoting the refinement of grains in the laser melting deposition-processed 316L auste nitic stainless steel.Moreover,the combined effect of these factors provides more active sites for the formation of a dense passive film with fewer point defects.展开更多
Synergistic interplays involving multiple active centers originating from TiO2 nanotube layers(TNT)and ruthenium(Ru)species comprising of both single atoms(SAs)and nanoparticles(NPs)augment the alkaline hydrogen evolu...Synergistic interplays involving multiple active centers originating from TiO2 nanotube layers(TNT)and ruthenium(Ru)species comprising of both single atoms(SAs)and nanoparticles(NPs)augment the alkaline hydrogen evolution reaction(HER)by enhancing Volmer kinetics from rapid water dissociation and improving Tafel kinetics from efficient H*desorption.Atomic layer deposition of Ru with 50 process cycles results in a mixture of Ru SAs and 2.8-0.4 nm NPs present on TNT layers,and it emerges with the highest HER activity among all the electrodes synthesized.A detailed study of the Ti and Ru species using different high-resolution techniques confirmed the presence of Ti^(3+)states and the coexistence of Ru SAs and NPs.With insights from literature,the role of Ti^(3+),appropriate work functions of TNT layers and Ru,and the synergistic effect of Ru SAs and Ru NPs in improving the performance of alkaline HER were elaborated and justified.The aforementioned characteristics led to a remarkable performance by having 9mV onset potentials and 33 mV dec^(-1) of Tafel slopes and a higher turnover frequency of 1.72 H2 s^(-1) at 30 mV.Besides,a notable stability from 28 h staircase chronopotentiometric measurements for TNT@Ru surpasses TNT@Pt in comparison.展开更多
The insulating nature and dissolution of vanadium-based oxides in aqueous electrolytes result in low capacity and lifespan during charge/discharge process, which is unable to meet the demands for the development and a...The insulating nature and dissolution of vanadium-based oxides in aqueous electrolytes result in low capacity and lifespan during charge/discharge process, which is unable to meet the demands for the development and application of high-energy-density aqueous zinc-ion batteries(AZIBs). Herein, a novel V_(2)O_(5-x)@C composite cathode consisting of conductive carbon coatings with abundant oxygen vacancies is specifically designed through plasma-enhanced chemical vapor deposition(PECVD) method. As expected,the ideal microstructure of V_(2)O_(5-x)@C cathode enables large specific surface areas, fast electron/ion diffusion kinetics, and superior interfacial stability, which can realize outstanding cycling stability and electrochemical performance. Consequently, the V_(2)O_(5-x)@C composite cathode delivers a high reversible rate capacity of 130.6 mAh/g at 10 A/g and remains 277.6 mAh/g when returned to 1 A/g. In addition, the Zn//V_(2)O_(5-x)@C full cell can stably cycle for 1000 cycles with a high initial specific capacity of 149.2 m Ah/g,possessing 83.8% capacity retention at 5 A/g. The process of constructing a conductive layer on the surface of cathode materials while increasing oxygen vacancies in the structure through PECVD provides new insight into the design of high-performance cathode materials for AZIBs.展开更多
Photoheranostics have emerged as a promising tool for cancer theranostics owing to their real-time feedback on treatment and their precise diagnosis.Among them,how to improve the photothermal conversion efficiency(PCE...Photoheranostics have emerged as a promising tool for cancer theranostics owing to their real-time feedback on treatment and their precise diagnosis.Among them,how to improve the photothermal conversion efficiency(PCE)of phototheranostic agents(PTAs)is the key factor for phototheranostic systems.Herein,we provided an efficient method to improve PCE and constructed a biocompatible nano-material ICR-Qu@NH_(2)-Fe_(3)O_(4)@PEG(QNFP)by combing near-infrared second region(NIR-Ⅱ)molecular dye ICR-Qu and amino-modified magnetic nanoparticles and then encapsulated by DSPE-m PEG2000.QNFP exhibited excellent performance for photothermal therapy with a high PCE of 95.6%.Both in vitro and in vivo experiments indicated that QNFP could inhibit the growth of tumors under laser irradiation with low toxicity and realized real-time NIR-Ⅱfiuorescent imaging of tumors.In general,we realized a simple but efficient method to improve the PCE of NIR-Ⅱmolecular dye without reduce its quantum yield,which is an ideal choice for cancer diagnosis and treatment.展开更多
A new combination method consisting of ball milling, carbothermic reduction and hydrochloric acid leaching was proposed for the preparation of nanosized synthetic rutile from natural ilmenite. The ball milling was emp...A new combination method consisting of ball milling, carbothermic reduction and hydrochloric acid leaching was proposed for the preparation of nanosized synthetic rutile from natural ilmenite. The ball milling was employed to grind ilmenite into small particles. The carbothermic reduction was carried out to yield a high titanium slag, which would be easily purified by subsequent leaching procedure. Factors affecting the hydrochloric acid process, namely the leaching time, temperature, and acid concentration, were studied. After leaching and calcining the milled and annealed mixture of FeTiO3/C under the optimal conditions, the TiO2 nanoparticles with size of 10-200 nm and purity〉98.0% were obtained.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52373235 and 52573322)the National Natural Science Foundation of Hubei Province of China(No.2024AFB568).
文摘Repolarizing tumor-associated macrophages(TAMs)toward the proinflammatory M1 phenotype represents a promising strategy to reverse the immunosuppressive tumor microenvironment(TME)and enhance antitumor immunotherapy.Recent studies have demonstrated that exogenous electrical stimulation can effectively repolarize TAMs toward the M1 phenotype.However,conventional electrical stimulation methods,relying on invasive implanted electrodes,are restricted to targeting localized tumor regions and pose inherent risks to patients.Notably,biological neural networks,distributed systems of interconnected neurons,can naturally permeate tissues and orchestrate cellular activities with high spatial efficiency.Inspired by this natural system,we developed a global in situ electric field network using piezoelectric BaTiO_(3)nanoparticles.Upon ultrasound stimulation,the nanoparticles generate a wireless electric field throughout the TME.In addtion,their nanoscale size enables them to function as synthetic“neurons”,allowing for uniform penetration throughout the tumor tissue and inducing significant repolarization of TAMs via the Ca^(2+)influx-activated nuclear factor-kappa B(NF-κB)signaling pathway.The repolarized M1 TAMs restore anti-tumor immunostimulatory functions and secrete key proinflammatory cytokines(e.g.,tumor necrosis factor-alpha(TNF-α)and interleukin-1 beta(IL-1β)),which enhance immunostimulation within the TME and directly contribute to tumor cell elimination.Remarkably,this strategy achieved robust in vivo tumor growth inhibition with excellent biosafety in a 4T1 breast tumor model.Overall,this work establishes a non-invasive,wireless electric field platform capable of globally repolarizing TAMs,offering a safe and efficient strategy to advance cancer immunotherapy and accelerate the clinical translation of bioelectronic therapies.
基金financially supported by the National Natural Science Foundation of China(Nos.51878092,51608067)the Scientific and Technological Innovation Special Program of Social Livelihood of Chongqing(No.cstc2015shmsztzx0053)the Fundamental Research Funds for the Central Universities(No.2019CDXYCH0026)
文摘Changes in solution chemistry and transport conditions can lead to the release of deposited MnO2 nanoparticles from a solid interface,allowing them to re-enter the aqueous environment.Understanding the release behavior of Mn02 nanoparticles from naturally occurring surfaces is critical for better prediction of the transport potential and environmental fate of Mn02 nanoparticles.In this study,the release of Mn02 nanoparticles was investigated using a quartz crystal microbalance with dissipation monitoring(QCM-D),and different environmental surface types,solution pH values and representative macromolecular organics were considered.Mn02 nanoparticles were first deposited on crystal sensors at elevated NaN03 concentrations before being rinsed with double-deionized water to induce their remobilization.The results reveal that the release rate of Mn02 depends on the surface type,in the decreasing order:SiO2>Fe304>Al2 O3,resulting from electrostatic interactions between the surface and particles.Moreover,differences in solution pH can lead to variance in the release behavior of Mn02 nanoparticles.The release rate from surfaces was significantly higher at pH 9.8 that at 4.5,indicating that alkaline conditions were more favorable for the mobilization of Mn02 in the aquatic environment.In the presence of macromolecular organics,bovine serum albumin(BSA)can inhibit the release of Mn02 from the surfaces due to attractive forces.In presence of humic acid(HA)and sodium alginate(SA),the Mn02 nanoparticles were more likely to be mobile,which may be associated with a large repulsive barrier imparted by steric effects.
基金supported by the Key R&D Program of Ningxia Hui Autonomous Region(2023BCF01045).
文摘Entomopathogenic viruses,such as baculoviruses and cypoviruses,have been employed as biological pesticides against agricultural and forestry pests.However,their susceptibility to inactivation under field UV radiation has hindered their broader application.In this study,we effectively improved the UV resistance of insect virus occlusion bodies(OBs)by coating their surfaces with silica nanoparticles(SiO_(2)NPs).Monodisperse SiO_(2)NPs with uniform size distribution and excellent colloidal stability were synthesized using the Stober method.Subsequent amination modification of the SiO_(2)NPs with a silane coupling agent shifted their isoelectric point from 3.2 to 8.1.This modification imparted a strong positive charge to the NPs within the pH range of 4.5-5.5,while the OBs of insect viruses remained negatively charged in this range.Consequently,the amino-functionalized SiO_(2)NPs were successfully coated onto the surfaces of OBs of three representative insect viruses:nucleopolyhedrovirus,granulovirus,and cypovirus,through electrostatic interactions.Laboratory bioassays confirmed that Mamestra brassicae multiple nucleopolyhedrovirus(MbMNPV)coated with SiO_(2)-NH2 NPs retained its native viral pathogenicity against Spodoptera exigua larvae under normal laboratory condition,while it demonstrated 2.299-2.712 folds higher potency than MbMNPV physically mixed with unmodified SiO_(2)NPs after UV irradiation.Outdoor trials revealed that SiO_(2)-NH_(2)NPs coating significantly improved the survival time of MbMNPV,with the median survival time increased from 1.43 days to 5.15 days.This nanoparticle coating strategy establishes a robust platform for developing photostable biopesticides while preserving their ecological safety profiles.The modular nature of this approach suggests its broad applicability across different entomopathogenic virus formulations.
基金financially supported by the National Natural Science Foundation of China(No.81802690)the Natural Science Foundation of Shaanxi Province(No.S2024-JCYB-1354)
文摘Wound healing remains a critical challenge in medical treatment,particularly for infected and complex wounds.This study introduces a novel spray able nanocomposite hydrogel dressing(SA/CaCl_(2)/CeO_(2),SCC)that demonstrates exceptional potential for accelerated wound healing and bacterial infection control.By integrating cerium oxide nanoparticles(CeO_(2)NPs)with sodium alginate(SA)and calcium chloride(CaCl_(2)),we developed a versatile and portable wound healing solution that possesses the ability to scavenge reactive oxygen species(ROS),remarkable biocompatibility,antibacterial properties,and regenerative capabilities.The synthesized SCC hydrogel was comprehensively characterized through advanced microscopic and spectroscopic techniques,revealing a unique nanostructured composition with intrinsic redox capacity.In vitro assessments demonstrated excellent cytocompatibility,hemocompatibility,and potent antibacterial activity against both gram-positive and gramnegative bacteria.In vivo rat wound model experiments further validated the hydrogel's therapeutic efficacy,showing significantly accelerated wound closure,reduced inflammatory responses,and enhanced tissue regeneration.Key innovations include the hydrothermal synthesis of CeO_(2)nanoparticles,a simple spray-induced crosslinking process,and the strategic incorporation of nanoparticles to modulate wound healing mechanisms.The SCC hydrogel exhibited superior performance in promoting granulation tissue formation,collagen deposition,and bacterial elimination,positioning it as a promising candidate for advanced wound management strategies.
文摘In this paper,polyamide(PA)woven fabric was used as the base fabric,and polyurethane(PU)solution containing silica nanoparticles(PU@SiO_(2)NPs)was used as the coating solution to prepare composite tent fabric(PA/PU@SiO_(2)).The morphology,structure,and durability of the tent fabric under ultraviolet(UV)radiation,waterstained,or thermal conditions were investigated.The results show that compared with PA/PU fabric without SiO_(2)NPs,when the mass fraction of SiO_(2)NPs in PU coating is 5%,the air permeability of PA/PU@SiO_(2)fabric decreases from about 7.5 to 6.0 nm/s,while the reflectivity to UVvisible light is significantly improved.The surface wettability decreases,as indicated by the average water contact angle(WCA)on PA/PU@SiO_(2)remaining stable at 47°after 9 min.After thermal treatment,the PA/PU@SiO_(2)fabric shows superior mechanical stability.The degradation rate of the tensile strength is only 6.3%,approximately half that of the PA/PU fabric.Meanwhile,the elongation at break increases to 98.9%,compared to 61.8%for the PA/PU fabric.
基金financially supported by the National Key R&D Program of China(No.2021YFB 3802400)the National Natural Science Foundation of China(Nos.U2130208,22279020 and 52301264)the Science and Technology Commission of Shanghai Municipality(Nos.23ZR1406500 and 22ZR1406500)
文摘As a typical reactive composite hydrogen storage system,2LiBH_(4)-MgH_(2)holds an ultrahigh hydrogen storage capacity of 11.5 wt%.However,it suffers from sluggish hydrogen storage kinetics due to the difficult nucleation of MgB_(2).Herein,amorphous VB_(2)nanoparticles with an average size of approximately 32 nm are synthesized to enhance the hydrogen storage performance of 2LiBH_(4)-MgH_(2)composite.VB_(2),sharing the same hexagonal structure with MgB_(2)with a d-value mismatch ratio of only 2.28%,could serve as effective nucleation sites for promoting the formation of MgB_(2).Theoretical calculations reveal that the introduction of VB_(2)significantly reduces the binding energies of B and Mg,facilitating in situ nucleation of MgB_(2).As a result,after the introduction of VB_(2)nanoparticles,complete hydrogen desorption of 9.23 wt%is achieved for 2LiBH_(4)-MgH_(2)within 2 h at 400℃,which is 4 times shorter than the time required for pure 2LiBH_(4)-MgH_(2),and no nucleation incubation period for hydrogen desorption is observed even at a low temperature of380℃.More importantly,a reversible capacity of9.3 wt%,corresponding to a capacity retention of 100%,could be preserved after 10 cycles of hydrogen storage,demonstrating stable reversible hydrogen storage performance.This study provides a novel technological pathway for improving the reversible hydrogen storage performance of composite metal hydrides and offers significant insights into the development of high-performance hydrogen storage materials.
基金supported by the Inner Mongolia Natural Science Foundation(2024QN02011)basic scientific research business expense project of colleges and universities directly under Inner Mongolia(2023QNJS131 and 2024QNJS127)Science and Technology Plan Program of Inner Mongolia Autonomous Region(2023YFDZ0031).
文摘Pure TiO_(2)and copper-modified titania(Cu/TiO_(2))nanoparticles were synthesized through sol gel combined with the pyrolysis method for the removal of Congo red(CR)in wastewater treatment.Surface morphology and structural evaluation utilized XRD,TEM,Raman,FTIR and BET techniques.Cu/TiO_(2)showed rich defects and a higher specific surface area than that of TiO_(2).The 1Cu/TiO_(2)(molar ratio Cu/TiO_(2)of 1/100)showed the best performance to adsorption of CR solution at different reaction conditions(contact duration,CR concentration,adsorbent dose,temperature,and initial pH).Adsorption kinetics and equilibrium isotherms were well-described with a pseudo-second-order kinetics and Freundlich model,respectively.The negative ΔG indicates stable adsorption of CR on the Cu/TiO_(2)surface.The adsorption efficiency only decreases by 6%after 5 cycles of adsorption regeneration.The successful synthesis of Cu/TiO_(2)offers a new possibility to address the problems related to CR dye from aqueous solutions.
基金supported by the National Natural Science Foundation of China(No.22568017)Guizhou Provincial Science and Technology Projects(No.ZKZD2023004)+2 种基金Key Laboratory of Carbon-based Energy Molecular Chemical Utilization Technology in Guizhou Province(No.2023008)One Hundred Person Project of Guizhou Province(No.GCC 2023013)Scientific and Technological Innovation Talents Team Project of Guizhou Province(No.CXTD2023029).
文摘Water electrolysis to produce hydrogen has broad prospects due to its pollution-free feature,yet its electrolysis efficiency is limited by the slow kinetics of the anodic oxygen evolution reaction(OER).In this study,we develop a synergistic catalyst which integrates MXene/TiO_(2)-supported Ru nanoparticles and oxygen-coordinated Co single atoms(RuCo-MXene/TiO_(2))for efficient OER.This double-tuned structure enables both high-density active sites and precise microenvironment control.Moreover,the interaction between metals during annealing process provides the generation of metallic-bonded Ru-Co pairs between Ru nanoparticles and Co single atoms,facilitating Ru nanoparticles-to-support charge transfer,resulting in optimized electronic properties of the catalyst.As expected,the as-synthesized RuCo-MXene/TiO_(2) catalyst at 10 mA·cm^(-2) current density exhibits 208 mV low overportential and a longterm stability of up to 500 h,which is superior to Ru-MXene/TiO_(2) and Co-MXene/TiO_(2).This work provides a promising strategy for designing efficient and stable electrocatalysts for renewable energy applications.
文摘The p-block metal(In,Sn,Bi,etc.)-based electrocatalysts have exhibited excellent activity in the electrocatalytic CO_(2)reduction(ECR)to formate.However,the rapid decrease in catalytic activity caused by catalyst reconstruction and agglomeration under ECR conditions significantly restricts their practical applications.Herein,we developed a sulfur anchoring strategy to stabilize the high-density sub-3 nm In_(2)S_(3)nanoparticles on sulfur-doped porous carbon substrates(i-In_(2)S_(3)/S-C)for formate production.Systematic characterizations evidenced that the as-prepared catalyst exhibited a strong metal sulfide-support interaction(MSSI),which effectively regulated the electronic states of In_(2)S_(3),achieving a high formate Faradaic efficiency of 91%at−0.95 V vs.RHE.More importantly,the sulfur anchoring effectively immobilized the sub-3 nm In_(2)S_(3)nanoparticles to prevent them from agglomeration.It enabled the catalysts to exhibit much higher durability than the In_(2)S_(3)samples without sulfur anchoring,demonstrating that the strong MSSI and fast charge transfer on the catalytic interface could significantly promote the structural stability of In_(2)S_(3)catalysts.These results provide a viable approach for developing efficient and stable electrocatalysts for CO_(2)reduction.
基金the National Natural Science Foundation of China(Nos.52473152,and 52273154)the Key Project of Natural Science Foundation of Zhejiang Province(No.LZ23B040002)is gratefully acknowledged.
文摘Gemcitabine(Gem)is the gold-standard chemotherapeutic drug for pancreatic cancer therapy in clinic.However,intratumoral bacteria can metabolize Gem into an inactive form,leading to Gem resistance.To address this challenge,Zn^(2+)-containing nanoparticles(ZGP NPs)are used to eliminate intracellular bacteria to enhance the therapeutic efficacy of Gem in pancreatic therapy.ZGP NPs are prepared via a facile one-pot method using Zn2+,epigallocatechin gallate(EGCG),and polyethylene glycol(PEG),which prevents metal ion chelation by proteins and ensures antibacterial activity.Leveraging the pH-responsive disassembly of metal-phenolic networks,ZGP NPs can be degraded in acidic lysosomes after cellular uptake,releasing Zn^(2+)to eliminate intracellular bacteria and thereby protecting Gem from bacteria-mediated inactivation.Moreover,the elimination of intratumoral bacteria enhances immunotherapy.The delivery of Zn^(2+)via ZGP NPs presents a promising strategy to eliminate intratumoral bacteria to overcome Gem resistance in pancreatic cancer therapy.
基金Project supported by National Natural Science Foundation of China(52071227)Central Government Guidance to Local Science and Technology Development(YDZJSK20231A046)Key Scientific Research Project in Shanxi Province(202102050201003,202102050201010)。
文摘In this study,the corrosion resistance and the stability of passive films on the laser melting depositionprocessed 316L austenitic stainless steel with varying CeO_(2)contents in the environment of proton exchange membrane fuel cells were investigated using a combination of electrochemical and microstructural analyses.The findings reveal that 316L austenitic stainless steel with 0.20 wt%CeO_(2)exhibits a superior corrosion resistance,primarily due to grain refinement,a high proportion of low-angle grain boundaries and low∑coincidence site lattice grain boundaries,as well as increased dislocation density.The addition of CeO_(2)optimizes the type and size of inclusions and exerts a drag effect on grain boundaries,promoting the refinement of grains in the laser melting deposition-processed 316L auste nitic stainless steel.Moreover,the combined effect of these factors provides more active sites for the formation of a dense passive film with fewer point defects.
基金support from the European Union Horizon 2020 program(project HERMES,nr.952184)the Ministry of Education,Youth and Sports of the Czech Republic for supporting CEMNAT(LM2023037)+1 种基金Czech-NanoLab(LM2023051)infrastructures for providing ALD,SEM,EDX,XPS,TEM,and XRDCzech Science Foundation(project 23-08019X,EXPRO).
文摘Synergistic interplays involving multiple active centers originating from TiO2 nanotube layers(TNT)and ruthenium(Ru)species comprising of both single atoms(SAs)and nanoparticles(NPs)augment the alkaline hydrogen evolution reaction(HER)by enhancing Volmer kinetics from rapid water dissociation and improving Tafel kinetics from efficient H*desorption.Atomic layer deposition of Ru with 50 process cycles results in a mixture of Ru SAs and 2.8-0.4 nm NPs present on TNT layers,and it emerges with the highest HER activity among all the electrodes synthesized.A detailed study of the Ti and Ru species using different high-resolution techniques confirmed the presence of Ti^(3+)states and the coexistence of Ru SAs and NPs.With insights from literature,the role of Ti^(3+),appropriate work functions of TNT layers and Ru,and the synergistic effect of Ru SAs and Ru NPs in improving the performance of alkaline HER were elaborated and justified.The aforementioned characteristics led to a remarkable performance by having 9mV onset potentials and 33 mV dec^(-1) of Tafel slopes and a higher turnover frequency of 1.72 H2 s^(-1) at 30 mV.Besides,a notable stability from 28 h staircase chronopotentiometric measurements for TNT@Ru surpasses TNT@Pt in comparison.
基金financially supported by the National Natural Science Foundation of China (No. 52377222)Natural Science Foundation of Hunan Province (No. 2023JJ20064)。
文摘The insulating nature and dissolution of vanadium-based oxides in aqueous electrolytes result in low capacity and lifespan during charge/discharge process, which is unable to meet the demands for the development and application of high-energy-density aqueous zinc-ion batteries(AZIBs). Herein, a novel V_(2)O_(5-x)@C composite cathode consisting of conductive carbon coatings with abundant oxygen vacancies is specifically designed through plasma-enhanced chemical vapor deposition(PECVD) method. As expected,the ideal microstructure of V_(2)O_(5-x)@C cathode enables large specific surface areas, fast electron/ion diffusion kinetics, and superior interfacial stability, which can realize outstanding cycling stability and electrochemical performance. Consequently, the V_(2)O_(5-x)@C composite cathode delivers a high reversible rate capacity of 130.6 mAh/g at 10 A/g and remains 277.6 mAh/g when returned to 1 A/g. In addition, the Zn//V_(2)O_(5-x)@C full cell can stably cycle for 1000 cycles with a high initial specific capacity of 149.2 m Ah/g,possessing 83.8% capacity retention at 5 A/g. The process of constructing a conductive layer on the surface of cathode materials while increasing oxygen vacancies in the structure through PECVD provides new insight into the design of high-performance cathode materials for AZIBs.
基金financially supported by the National Natural Science Foundation of China(Nos.U21A20308,22077088)Foundation from Science and Technology Major Project of Tibetan Autonomous Region of China(No.XZ202201ZD0001G)Foundation from Science and Technology Department of Sichuan Province(No.2021ZHCG0025)。
文摘Photoheranostics have emerged as a promising tool for cancer theranostics owing to their real-time feedback on treatment and their precise diagnosis.Among them,how to improve the photothermal conversion efficiency(PCE)of phototheranostic agents(PTAs)is the key factor for phototheranostic systems.Herein,we provided an efficient method to improve PCE and constructed a biocompatible nano-material ICR-Qu@NH_(2)-Fe_(3)O_(4)@PEG(QNFP)by combing near-infrared second region(NIR-Ⅱ)molecular dye ICR-Qu and amino-modified magnetic nanoparticles and then encapsulated by DSPE-m PEG2000.QNFP exhibited excellent performance for photothermal therapy with a high PCE of 95.6%.Both in vitro and in vivo experiments indicated that QNFP could inhibit the growth of tumors under laser irradiation with low toxicity and realized real-time NIR-Ⅱfiuorescent imaging of tumors.In general,we realized a simple but efficient method to improve the PCE of NIR-Ⅱmolecular dye without reduce its quantum yield,which is an ideal choice for cancer diagnosis and treatment.
基金Project (2007CB613601) supported by the National Basic Research Program of ChinaProject supported by the Postdoctoral Science Foundation of Central South University, China
文摘A new combination method consisting of ball milling, carbothermic reduction and hydrochloric acid leaching was proposed for the preparation of nanosized synthetic rutile from natural ilmenite. The ball milling was employed to grind ilmenite into small particles. The carbothermic reduction was carried out to yield a high titanium slag, which would be easily purified by subsequent leaching procedure. Factors affecting the hydrochloric acid process, namely the leaching time, temperature, and acid concentration, were studied. After leaching and calcining the milled and annealed mixture of FeTiO3/C under the optimal conditions, the TiO2 nanoparticles with size of 10-200 nm and purity〉98.0% were obtained.
