Radiotherapy is widely used clinically, but the toxic and side effects of nonselective killing of high-energy radiation limit its application. Finding biocompatible materials to assemble radiotherapy sensitizers and s...Radiotherapy is widely used clinically, but the toxic and side effects of nonselective killing of high-energy radiation limit its application. Finding biocompatible materials to assemble radiotherapy sensitizers and studying their sensitization patterns are of great significance for the clinical application. Here, biocompatible zinc porphyrin was chosen as sub-unit to construct various dimensional coordination frameworks. By employing top-down approach, suitable nanoframeworks with various dimensional zinc porphyrin were synthesized as radiosensitizers. The experimental data showed that high-dimensional zinc porphyrin nanoframeworks exhibit higher X-ray response performance.展开更多
Radiotherapy is one of the main therapeutic methods for cancers;however,nonselective killing of normal cells and tumor cells by X-ray inevitably results in toxicity and side effects.Developing low-toxicity and high-ef...Radiotherapy is one of the main therapeutic methods for cancers;however,nonselective killing of normal cells and tumor cells by X-ray inevitably results in toxicity and side effects.Developing low-toxicity and high-efficiency radiosensitizers to reduce the practical dose of X-ray is a promising approach to overcoming these side effects.Here,we report the use of carboxylatecontaining organic ligands to construct one-dimensional high-Z lanthanide chains for efficient response to X-ray.The onedimensional lanthanide chains are stacked through weak interactions to form coordination nanoframeworks in the presence of polyethylenimine(PEI).The morphology and activity of the synthesized nanoframeworks can be regulated through selenium atom engineering.This study presents a promising approach for effective radiotherapy through selenium-engineering stable lanthanide nanoframeworks with precise coordination structures as radiosensitizers to mitigate X-ray side effects.展开更多
The sluggish kinetics and high cost of the noble-metal based electrocatalyst for oxygen evolution reaction(OER)still seriously limits the efficiencies of water splitting.Herein,for the first time,we rationally design ...The sluggish kinetics and high cost of the noble-metal based electrocatalyst for oxygen evolution reaction(OER)still seriously limits the efficiencies of water splitting.Herein,for the first time,we rationally design a porous hierarchical nanoarchitecture,constructed by ultrathin CoSe_(2)embedded Fe-CoO nanosheets(CoSe_(2)@Fe-CoO),which is synthesized via self-assembly hydrolysis driven in-situ synergetic selenization of Fe/Co/O/Se precursor followed by Ostwald ripening.As an OER catalyst,the porous CoSe_(2)@Fe-CoO hybrid with abundant CoOOH electroactive sites delivers a small Tafel of 56.2 m V/dec with very low onset overpotential of 280 m V@10 m A/cm~2and excellent long-term physicochemical stability till 62h without obvious decay,which outperforms well-established benchmark electrocatalysts(RuO_(2)).The boosted OER performance of CoSe_(2)@Fe-CoO nanosheets is mainly attributed to its iron-doping effect,porous nanoarchitecture,and multicomponent synergetic/interfacial effect between ultrathin cobalt(II)oxide and conductive cobalt selenide(CoSe_(2))nanoframework.This work presents a facile construction strategy to find a nonprecious hybrid OER electrocatalyst with excellent performance and long-term stability.展开更多
基金supported by National Natural Science Foundation of China (Nos. 21877049, 22177038, 32171296)Guangdong Natural Science Foundation (Nos. 2020B1515120043, 2022A1515012235)+2 种基金Major Program for Tackling Key Problems of Industrial Technology in Guangzhou (Nos. 201902020013)Guangdong Pearl River Talent Program (No. 2017GC010354)Innovation Team Project in Guangdong Colleges and Universities (Nos. 2019KCXTD008, 2019KTSCX012)。
文摘Radiotherapy is widely used clinically, but the toxic and side effects of nonselective killing of high-energy radiation limit its application. Finding biocompatible materials to assemble radiotherapy sensitizers and studying their sensitization patterns are of great significance for the clinical application. Here, biocompatible zinc porphyrin was chosen as sub-unit to construct various dimensional coordination frameworks. By employing top-down approach, suitable nanoframeworks with various dimensional zinc porphyrin were synthesized as radiosensitizers. The experimental data showed that high-dimensional zinc porphyrin nanoframeworks exhibit higher X-ray response performance.
基金supported by the National Natural Science Foundation of China(Nos.21877049,22177038,and 32171296)Guangdong Natural Science Foundation(Nos.2022A1515012235 and 2020B1515120043)+1 种基金Guangdong Pearl River Talent Program(No.2017GC010354)Innovation Team Project in Guangdong Colleges and Universities(Nos.2019KCXTD008 and 2019KTSCX012).
文摘Radiotherapy is one of the main therapeutic methods for cancers;however,nonselective killing of normal cells and tumor cells by X-ray inevitably results in toxicity and side effects.Developing low-toxicity and high-efficiency radiosensitizers to reduce the practical dose of X-ray is a promising approach to overcoming these side effects.Here,we report the use of carboxylatecontaining organic ligands to construct one-dimensional high-Z lanthanide chains for efficient response to X-ray.The onedimensional lanthanide chains are stacked through weak interactions to form coordination nanoframeworks in the presence of polyethylenimine(PEI).The morphology and activity of the synthesized nanoframeworks can be regulated through selenium atom engineering.This study presents a promising approach for effective radiotherapy through selenium-engineering stable lanthanide nanoframeworks with precise coordination structures as radiosensitizers to mitigate X-ray side effects.
基金the National Natural Science Foundation of China(Grant Nos.21773024,51372033)。
文摘The sluggish kinetics and high cost of the noble-metal based electrocatalyst for oxygen evolution reaction(OER)still seriously limits the efficiencies of water splitting.Herein,for the first time,we rationally design a porous hierarchical nanoarchitecture,constructed by ultrathin CoSe_(2)embedded Fe-CoO nanosheets(CoSe_(2)@Fe-CoO),which is synthesized via self-assembly hydrolysis driven in-situ synergetic selenization of Fe/Co/O/Se precursor followed by Ostwald ripening.As an OER catalyst,the porous CoSe_(2)@Fe-CoO hybrid with abundant CoOOH electroactive sites delivers a small Tafel of 56.2 m V/dec with very low onset overpotential of 280 m V@10 m A/cm~2and excellent long-term physicochemical stability till 62h without obvious decay,which outperforms well-established benchmark electrocatalysts(RuO_(2)).The boosted OER performance of CoSe_(2)@Fe-CoO nanosheets is mainly attributed to its iron-doping effect,porous nanoarchitecture,and multicomponent synergetic/interfacial effect between ultrathin cobalt(II)oxide and conductive cobalt selenide(CoSe_(2))nanoframework.This work presents a facile construction strategy to find a nonprecious hybrid OER electrocatalyst with excellent performance and long-term stability.
