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Artificial Neural Network Model for Thermal Conductivity Estimation of Metal Oxide Water-Based Nanofluids
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作者 Nikhil S.Mane Sheetal Kumar Dewangan +3 位作者 Sayantan Mukherjee Pradnyavati Mane Deepak Kumar Singh Ravindra Singh Saluja 《Computers, Materials & Continua》 2026年第1期316-331,共16页
The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids.Researchers rely on experimental investigations to explore nanofluid properties,as it is a n... The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids.Researchers rely on experimental investigations to explore nanofluid properties,as it is a necessary step before their practical application.As these investigations are time and resource-consuming undertakings,an effective prediction model can significantly improve the efficiency of research operations.In this work,an Artificial Neural Network(ANN)model is developed to predict the thermal conductivity of metal oxide water-based nanofluid.For this,a comprehensive set of 691 data points was collected from the literature.This dataset is split into training(70%),validation(15%),and testing(15%)and used to train the ANN model.The developed model is a backpropagation artificial neural network with a 4–12–1 architecture.The performance of the developed model shows high accuracy with R values above 0.90 and rapid convergence.It shows that the developed ANN model accurately predicts the thermal conductivity of nanofluids. 展开更多
关键词 Artificial neural networks nanofluids thermal conductivity PREDICTION
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Effect of N-doped GO quantum dots with MoS_(2) and Al_(2)O_(3)nanofluids on the surface quality of hot rolling of copper and steel plates
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作者 Sang Xiong Chenyi Yan Yue Qi 《Nano Materials Science》 2026年第1期78-92,共15页
A solvothermal approach was used to generate N-doped graphene oxide quantum dots(NGOQDs)using MoS_(2) and Al_(2)O_(3)nanocomposites.Through the use of TEM,XRD,Raman,ATR-FTIR,and XPS,the produced composites'shape,c... A solvothermal approach was used to generate N-doped graphene oxide quantum dots(NGOQDs)using MoS_(2) and Al_(2)O_(3)nanocomposites.Through the use of TEM,XRD,Raman,ATR-FTIR,and XPS,the produced composites'shape,composition,and structure were described.Tribological behavior and lubrication properties of NGOQDsMoS_(2) and NGOQDs-Al_(2)O_(3)nanocomposites as additive in nanofluids during hot roll cladding of copper and steel were studied and rolling lubrication mechanism was disclosed.The outcome demonstrates that tribological performance may be greatly enhanced by combining NGOQDs,and surface quality of the rolled copper and steel,and the addition of NGOQDs-MoS_(2) and NGOQDs-Al_(2)O_(3)nanoparticles can further improve the hot-rolling lubrication properties.The tribofilm,formed through the tribochemically induced lubrication process,significantly enhances the wear and corrosion resistance of rolled copper and steel surfaces. 展开更多
关键词 Graphene oxide quantum dots Tribological behavior ADDITIVES NANOFLUID
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Irreversibility analysis and multiple cubic regression based efficiency evaluation of ternary nanofluids(TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O and TiO_(2)+SiO_(2)+Cu/H_(2)O)via converging/diverging channels 被引量:1
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作者 Siddhant Taneja Sapna Sharma Bhuvaneshvar Kumar 《Acta Mechanica Sinica》 2025年第6期63-75,共13页
This study numerically examines the heat and mass transfer characteristics of two ternary nanofluids via converging and diverg-ing channels.Furthermore,the study aims to assess two ternary nanofluids combinations to d... This study numerically examines the heat and mass transfer characteristics of two ternary nanofluids via converging and diverg-ing channels.Furthermore,the study aims to assess two ternary nanofluids combinations to determine which configuration can provide better heat and mass transfer and lower entropy production,while ensuring cost efficiency.This work bridges the gap be-tween academic research and industrial feasibility by incorporating cost analysis,entropy generation,and thermal efficiency.To compare the velocity,temperature,and concentration profiles,we examine two ternary nanofluids,i.e.,TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O and TiO_(2)+SiO_(2)+Cu/H_(2)O,while considering the shape of nanoparticles.The velocity slip and Soret/Dufour effects are taken into consideration.Furthermore,regression analysis for Nusselt and Sherwood numbers of the model is carried out.The Runge-Kutta fourth-order method with shooting technique is employed to acquire the numerical solution of the governed system of ordinary differential equations.The flow pattern attributes of ternary nanofluids are meticulously examined and simulated with the fluc-tuation of flow-dominating parameters.Additionally,the influence of these parameters is demonstrated in the flow,temperature,and concentration fields.For variation in Eckert and Dufour numbers,TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O has a higher temperature than TiO_(2)+SiO_(2)+Cu/H_(2)O.The results obtained indicate that the ternary nanofluid TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O has a higher heat transfer rate,lesser entropy generation,greater mass transfer rate,and lower cost than that of TiO_(2)+SiO_(2)+Cu/H_(2)O ternary nanofluid. 展开更多
关键词 Converging/Diverging channels Ternary nanofluids Multiple cubic regression Entropy generation
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Thermo-Hydrodynamic Characteristics of Hybrid Nanofluids for Chip-Level Liquid Cooling in Data Centers: A Review of Numerical Investigations 被引量:1
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作者 Yifan Li Congzhe Zhu +2 位作者 Zhihan Lyu Bin Yang Thomas Olofsson 《Energy Engineering》 2025年第9期3525-3553,共29页
The growth of computing power in data centers(DCs)leads to an increase in energy consumption and noise pollution of air cooling systems.Chip-level cooling with high-efficiency coolant is one of the promising methods t... The growth of computing power in data centers(DCs)leads to an increase in energy consumption and noise pollution of air cooling systems.Chip-level cooling with high-efficiency coolant is one of the promising methods to address the cooling challenge for high-power devices in DCs.Hybrid nanofluid(HNF)has the advantages of high thermal conductivity and good rheological properties.This study summarizes the numerical investigations of HNFs in mini/micro heat sinks,including the numerical methods,hydrothermal characteristics,and enhanced heat transfer technologies.The innovations of this paper include:(1)the characteristics,applicable conditions,and scenarios of each theoretical method and numerical method are clarified;(2)the molecular dynamics(MD)simulation can reveal the synergy effect,micro motion,and agglomeration morphology of different nanoparticles.Machine learning(ML)presents a feasiblemethod for parameter prediction,which provides the opportunity for the intelligent regulation of the thermal performance of HNFs;(3)the HNFs flowboiling and the synergy of passive and active technologies may further improve the overall efficiency of liquid cooling systems in DCs.This review provides valuable insights and references for exploring the multi-phase flow and heat transport mechanisms of HNFs,and promoting the practical application of HNFs in chip-level liquid cooling in DCs. 展开更多
关键词 Data centers chip-level liquid cooling hybrid nanofluid energy transport characteristic hydrodynamic performance numerical investigation
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Improving Heat Transfer Performance of Flat Plate Water Solar Collectors Using Nanofluids
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作者 Barhm Mohamad 《Journal of Harbin Institute of Technology(New Series)》 2025年第2期80-89,共10页
This study delves into both experimental and analytical examinations of heat exchange in a straight channel, where Al_(2)O_(3)-water nanofluids are utilized, spanning the Reynolds number spectrum from 100 to 1800. Div... This study delves into both experimental and analytical examinations of heat exchange in a straight channel, where Al_(2)O_(3)-water nanofluids are utilized, spanning the Reynolds number spectrum from 100 to 1800. Diverse volume fractions(1%, 2%, and 3%) of Al_(2)O_(3)-water nanofluids are meticulously prepared and analyzed. The essential physical properties of these nanofluids, critical for evaluating their thermal and flow characteristics, have been comprehensively assessed. From a quantitative perspective, numerical simulations are employed to predict the Nusselt number(Nu) and friction factor(f). The empirical findings reveal intriguing trends: the friction factor experiences an upward trend with diminishing velocity, attributed to heightened molecular cohesion. Conversely, the friction factor demonstrates a decline with diminishing volume fractions, a consequence of reduced particle size. Both the nanofluid's viscosity and heat transfer coefficient exhibit a rise in tandem with augmented volume flow rate and concentration gradient. Notably, the simulation results harmonize remarkably well with experimental data. Rigorous validation against prior studies underscores the robust consistency of these outcomes. In the pursuit of augmenting heat transfer, a volume fraction of 3% emerges as particularly influential, yielding an impressive 53.8% enhancement. Minor increments in the friction factor, while present, prove negligible and can be safely overlooked. 展开更多
关键词 Nusselt number friction factor nanofluids flat plate solar collectors solar energy
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Hybrid Nanofluids Mixed Convection inside a Partially Heated Square Enclosure with Driven Sidewalls
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作者 Meriem Bounib Aicha Bouhezza +4 位作者 Abdelkrim Khelifa Mohamed Teggar Hasan Köen Aissa Atia Yassine Cherif 《Frontiers in Heat and Mass Transfer》 2025年第4期1323-1350,共28页
This study investigates laminar convection in three regimes(forced convection,mixed convection,and natural convection)of a bi-nanofluid(Cu-Al_(2)O_(3)-water)/mono-nanofluid(Al_(2)O_(3)-water)inside a square enclosure ... This study investigates laminar convection in three regimes(forced convection,mixed convection,and natural convection)of a bi-nanofluid(Cu-Al_(2)O_(3)-water)/mono-nanofluid(Al_(2)O_(3)-water)inside a square enclosure of sliding vertical walls which are kept at cold temperature and moving up,down,or in opposite directions.The enclosure bottom is heated partially by a central heat source of various sizes while the horizontal walls are considered adiabatic.The thermal conductivity and dynamic viscosity are dependent on temperature and nanoparticle size.The conservation equations are implemented in the solver ANSYS R2(2020).The numerical predictions are successfully validated by comparison with data from the literature.Numerical simulations are carried out for various volume fractions of solid mono/hybrid-nanoparticles(0≤ϕ≤5%),Richardson numbers(0.001≤Ri≤10),and hot source lengths((1/5)H≤ε≤(4/5)H).Isothermal lines,streamlines,and average Nusselt numbers are analyzed.The thermal performance of nanofluids is compared to that of the base heat transfer fluid(water).Outcomes illustrate the flow characteristics significantly affected by the convection regime,hot source size,sidewall motion,and concentration of solid nanoparticles.In the case of sidewalls moving downward,using hybrid nanofluid(Cu-Al_(2)O_(3)-water)shows the highest heat transfer rate in the enclosure at Ri=1,ε=(4/5)H and volume fraction ofφ=5%where a significant increment(25.14%)of Nusselt number is obtained. 展开更多
关键词 Mixed convection heat transfer enhancement hybrid nanofluid nanoparticles Richardson number
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Analysis of Heat Transfer inside Rectangular Micro-Channel with Wavy Surface and Hybrid Nanofluids
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作者 Banan Najim Abdullah Karam Hashim Mohammed +2 位作者 Ammar Hassan Soheel Bashar Mahmood Ali Omar Rafae Alomar 《Frontiers in Heat and Mass Transfer》 2025年第5期1681-1700,共20页
The current work aims to numerically investigate the impact of using(50%ZnO and 50%Al_(2)O_(3))hybrid nanofluid(HNf)on the performance of convective heat transfer inside a horizontal wavy micro-channel.This issue repr... The current work aims to numerically investigate the impact of using(50%ZnO and 50%Al_(2)O_(3))hybrid nanofluid(HNf)on the performance of convective heat transfer inside a horizontal wavy micro-channel.This issue represents a novel approach that has not been extensively covered in previous research and provides more valuable insights into the performance of HNfs in complex flow geometries.The conjugate heat transfer approach is used to demonstrate the influence of adding hybrid nanoparticles(50%Al_(2)O_(3) and 50%ZnO)to pure water on the rate of heat transfer.The governing equations are numerically solved by using ANSYS FLUENT(2021 R2).The behaviors of convective heat transfer coefficient(HTC),Nusselt number(Nu)and pressure drop are presented under various volume concentrations of(1%,2%and 3%)and Reynolds numbers(Re=600,1200 and 1800).The numerical results are validated against the experimental one,where the validation test shows a good agreement between them.The findings display that the highest HTC enhancement is reached at 59.5%when using a volume concentration of 3%and Re=1800.TheNusselt number is increased with the rise in volume concentration of nanoparticles,where the value of the Nusselt number is improved by 42.25%at 3%volume concentration.The reduction in pressure is raised with an increase in volume concentration and Re.The results also show that the combination of dispersion characteristics,Brownian movement and nanoparticles leads to an improvement in the rate of heat transfer.It is concluded that Nu and the behavior of heat transfer are considerably enhanced when using a hybrid nanofluid inside a wavy micro-channel. 展开更多
关键词 Hybrid nanofluid conjugate heat transfer wavy channel Brownian motion
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Experimental Study of Forced Convective Heat Transfer in a Copper Tube Using Three Types of Nanofluids
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作者 Zahraa N.Hussain Jamal M.Ali +2 位作者 Hasan S.Majdi Abbas J.Sultan H.Al-Naseri 《Fluid Dynamics & Materials Processing》 2025年第2期351-370,共20页
The use of nanofluids as heat transfer media represents an innovative strategy to enhance heat transfer performances.This study investigates experimentally the turbulent convective heat transfer characteristics of wat... The use of nanofluids as heat transfer media represents an innovative strategy to enhance heat transfer performances.This study investigates experimentally the turbulent convective heat transfer characteristics of waterbased nanofluids containing TiO_(2),CuO,and graphene nanoplatelet(GNP)nanoparticles as they flow through a copper tube.Both the dynamic viscosity and thermal conductivity of these nanofluids were modeled and experimentally measured across varying nanoparticle concentrations(0.01,0.02,and 0.03 vol.%)and temperatures(25℃,35℃,and 45℃).The findings indicate that the behavior of nanofluids depends on the parameter used for comparison with the base fluid.Notably,both the friction factor and heat transfer coefficient increase with higher nanoparticle volume concentrations at a constant Reynolds number.The results further reveal that the GNP/water nanofluid,with a volume concentration of 0.03%at 45℃,exhibit the highest Nusselt number,followed by the CuO/water and TiO_(2)/water nanofluids,with respective increases of 17.8%,11.09%,and 8.11%. 展开更多
关键词 NANOFLUID heat transfer coefficient thermal conductivity heat transfer enhancement
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Applications of variable thermal features for the bioconvective flow of Jeffrey nanofluids due to stretching surface with masssuction effects:Cattaneo-Christov model
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作者 S.U.KHAN M.GARAYEV +4 位作者 ADNAN K.RAMESH M.EL MELIGY D.ABDUVALIEVA M.I.KHAN 《Applied Mathematics and Mechanics(English Edition)》 2025年第2期391-402,共12页
The thermal nanofluids have garnered widespread attention for their use in multiple thermal systems,including heating processes,sustainable energy,and nuclear reactions.Research on nanofluids has revealed that the the... The thermal nanofluids have garnered widespread attention for their use in multiple thermal systems,including heating processes,sustainable energy,and nuclear reactions.Research on nanofluids has revealed that the thermal efficiencies of such materials are adversely affected by various thermal features.The purpose of the current work is to demonstrate the thermal analysis of Jeffrey nanofluids with the suspension of microorganisms in the presence of variable thermal sources.The variable effects of thermal conductivity,Brownian diffusivity,and motile density are utilized.The investigated model also reveals the contributions of radiation phenomena and chemical reactions.A porous,saturated,moving surface with a suction phenomenon promotes flow.The modeling of the problem is based on the implementation of the Cattaneo-Christov approach.The convective thermal constraints are used to promote the heat transfer features.A simplified form of the governing model is treated with the assistance of a shooting technique.The physical effects of different parameters for the problem are presented.The current problem justifies its applications in heat transfer,coating processes,heat exchangers,cooling systems in microelectronics,solar systems,chemical processes,etc. 展开更多
关键词 Jeffrey nanofluid bioconvection effect variable thermal consequence chemical reaction numerical simulation
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Performance Analysis of Solar Porous Media Collector Integrated with Thermal Energy Storage Charged by CuFe_(2)O_(4)/Water Nanofluids Coil Tubes
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作者 Ahmad Mola Sahira H.Ibrahim +1 位作者 Nagham Q.Shari Hasanain A.Abdul Wahhab 《Energy Engineering》 2025年第6期2239-2255,共17页
High-efficiency solar energy systems are characterized by their designs,which primarily rely on effective concentration and conversion methods of solar radiation.Evaluation of the performance enhancement of flat plate... High-efficiency solar energy systems are characterized by their designs,which primarily rely on effective concentration and conversion methods of solar radiation.Evaluation of the performance enhancement of flat plate solar collectors by integration with thermal energy storage could be achieved through simulation of proposed designs.The work aims to analyze a new solar collector integrated with a porous medium and shell and coiled tube heat exchanger.The heat transfer enhancement was investigated by varying the geometrical parameters in shell and helically coiled tubes operating with CuFe_(2)O_(4)/water with different volume fractions of 0.02%,0.05%,and 0.1 vol.%.This study presents an experimental and numerical investigation of the performance of the flat plate solar collector integrated with a helical coil heat exchanger using nanofluids.The solar collector has a dimension of 180 cm×80 cm and works with close-loop systems operated by the thermo siphon method.Two types of helical coil heat exchangers,Coil-A and Coil-B have been investigated.The diameter of the glass porous media was investigated at 2,5,and 10 mm.The results manifested that the enhancement in the Nusselt number of the nanofluid reached maximum values of 15%,18%,and 22%for nanofluid ferrofluid with volume concentrations of 0.02%,0.05%,and 0.1%,respectively,for Coil-A.The maximum values of Nusselt number enhancement were 14%,17%,and 20%for ferrofluid concentrations of 0.02%,0.05%,and 0.1 vol.%,respectively,for Coil-B.The results also elucidated that the nanofluid mass flow and heat transfer rates could be noticeably compared to water.Where the increase is 5%,10%,and 20%for each concentration and diameter of the porous media,it specifies the enormous ranges of operational and geometrical parameters. 展开更多
关键词 nanofluids porous medium solar collector solar water heater thermal storage materials
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SRM Simulation of Thermal Convective on MHD Nanofluids across Moving Flat Plate
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作者 Shahina Akter Muhammad Amer Qureshi Mohammad Ferdows 《Frontiers in Heat and Mass Transfer》 2025年第3期1013-1036,共24页
This study explores free convective heat transfer in an electrically conducting nanofluid flow over a moving semi-infinite flat plate under the influence of an induced magnetic field and viscous dissipation.The veloci... This study explores free convective heat transfer in an electrically conducting nanofluid flow over a moving semi-infinite flat plate under the influence of an induced magnetic field and viscous dissipation.The velocity and magnetic field vectors are aligned at a distance from the plate.The Spectral Relaxation Method(SRM)is used to numerically solve the coupled nonlinear partial differential equations,analyzing the effects of the Eckert number on heat and mass transfer.Various nanofluids containing Cu,Ag,Al_(2)O_(3),and TiO_(2) nanoparticles are examined to assess how external magnetic fields influence fluid behavior.Key parameters,including the nanoparticle volume fraction ϕ,magnetic parameter M,magnetic Prandtl number Prm,and Eckert number Ec,are evaluated for their impact on velocity,induced magnetic field,and heat transfer.Results indicate that increasing the magnetic parameter reduces velocity and magnetic field components in alumina-water nanofluids,while a higher nanoparticle volume fraction enhances the thermal boundary layer.Greater viscous dissipation(Ec)increases temperature,and Al_(2)O_(3) nanofluids exhibit higher speeds than Cu,Ag,and TiO_(2) due to density differences.Silver-water nanofluids,with their higher density,move more slowly.The SRM results closely align with those from Maple,confirming the method’s accuracy. 展开更多
关键词 Aligned induced magnetic field MATLAB NANOFLUID spectral relaxation method(SRM) viscous dissipation
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Radiative Flow of Ag-Fe_(3)O_(4)/Water Hybrid Nanofluids Induced by a Shrinking/Stretching Disk with Influence of Velocity and Thermal Slip Conditions
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作者 Muhammad Zubair Mustafa Sumera Dero +2 位作者 Liaquat Ali Lund Mehboob Ul Hassan Umair Khan 《Computer Modeling in Engineering & Sciences》 2025年第4期499-513,共15页
This paper discusses the model of the boundary layer(BL)flow and the heat transfer characteristics of hybrid nanofluid(HNF)over shrinking/stretching disks.In addition,the thermal radiation and the impact of velocity a... This paper discusses the model of the boundary layer(BL)flow and the heat transfer characteristics of hybrid nanofluid(HNF)over shrinking/stretching disks.In addition,the thermal radiation and the impact of velocity and thermal slip boundary conditions are also examined.The considered hybrid nano-fluid contains silver(Ag)and iron oxide(Fe_(3)O_(4))nanoparticles dispersed in the water to prepare the Ag-Fe_(3)O_(4)/water-based hybrid nanofluid.The requisite posited partial differential equations model is converted to ordinary differential equations using similarity transformations.For a numerical solution,the shooting method in Maple is employed.Moreover,the duality in solutions is achieved for both cases of the disk(stretching(λ>0)and shrinking(λ<0)).At the same time,a unique solution is observed for λ=0.No solution is found for them at λ<λ_(c),whereas the solutions are split at the λ=λ_(c).Besides,the value of the λ_(c) is dependent on the φ_(hnf).Meanwhile,the values of f″(0)and -θ′(0)intensified with increasing φ_(hnf).Stability analysis has been applied using bvp4c in MATLAB software due to a dual solution.Furthermore,analysis shows that the first solution is stable and feasible physically.For the slip parameters,an increase in the velocity slip parameter increases the velocity and shear stress profiles while increasing the temperature profile in the first solutions.While the rise in thermal slip parameter reduces the temperature profile nanoparticle volume fractions increase it. 展开更多
关键词 Dual solutions slip and radiation hybrid nanofluid shrinking/stretching disk stability analysis
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Double Diffusion Convection in Sisko Nanofluids with Thermal Radiation and Electroosmotic Effects: A Morlet-Wavelet Neural Network Approach
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作者 Arshad Riaz Misbah Ilyas +3 位作者 Muhammad Naeem Aslam Safia Akram Sami Ullah Khan Ghaliah Alhamzi 《Computer Modeling in Engineering & Sciences》 2025年第12期3481-3509,共29页
Peristaltic transport of non-Newtonian nanofluids with double diffusion is essential to biological engineering,microfluidics,and manufacturing processes.The authors tackle the key problem of Sisko nanofluids under dou... Peristaltic transport of non-Newtonian nanofluids with double diffusion is essential to biological engineering,microfluidics,and manufacturing processes.The authors tackle the key problem of Sisko nanofluids under double diffusion convection with thermal radiations and electroosmotic effects.Thestudy proposes a solution approach by using Morlet-Wavelet Neural Networks that can effectively solve this complex problem by their superior ability in the capture of nonlinear dynamics.These convergence analyses were calculated across fifty independent runs.Theil’s Inequality Coefficient and theMean Squared Error values range from 10^(-7) to 10^(-5) and 10^(-7) to 10^(-10),respectively.These values showed the proposed method is scientifically reliable and fast converging.Studies reveal that the intensity of the magnetic field causes a reduction in the flow velocity profile in the center of the channel.It is also evaluated that thermal radiations enhance the energy of the system,which promotes thermally induced diffusion and particle flow.The physical applications of this work pertain to improving fluid flow and heat transfer in engineering structures like converters or cooling devices or magnetic fluids in electronics,energy,and biomedical applications,where optimal control of fluid behavior is of paramount importance. 展开更多
关键词 Sisko nanofluid double diffusion induced magnetic field thermal radiations Morlet-Wavelet Neural Networks(MWNNs) electroosmosis
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纳米流体在页岩表面的吸附规律与机理
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作者 赵宇 张剑 +4 位作者 蒋庞露 邓森 贺亮 宫连杰 梁立豪 《大庆石油地质与开发》 北大核心 2026年第2期76-81,共6页
纳米流体常被用于提高非常规油藏采收率,为明确其在页岩表面吸附规律与机理,利用Lambert-Beer定律,通过吸光度与吸附量的关系对纳米流体在页岩表面的吸附规律进行研究。将纳米流体与页岩粉末混合、振荡并控制温度以达到吸附平衡,测量溶... 纳米流体常被用于提高非常规油藏采收率,为明确其在页岩表面吸附规律与机理,利用Lambert-Beer定律,通过吸光度与吸附量的关系对纳米流体在页岩表面的吸附规律进行研究。将纳米流体与页岩粉末混合、振荡并控制温度以达到吸附平衡,测量溶液浓度的变化以计算吸附量。研究了3种不同纳米流体的最佳浓度和平衡吸附时间,明确了纳米流体在页岩表面的吸附类型以及温度对其吸附规律的影响,进一步探讨了纳米流体改变润湿性的吸附机理。结果表明:SD、GP、DG 3种纳米流体的平衡吸附时间均为25 min;随着温度升高,纳米流体的平衡吸附量出现不同程度减少,纳米流体在页岩颗粒表面的吸附规律符合Langmuir单层吸附曲线;纳米流体均能够改变页岩表面的润湿性,SD、GP纳米流体能够实现页岩表面的润湿反转。研究成果为纳米流体在页岩油藏增产中的进一步应用推广提供了依据。 展开更多
关键词 纳米流体 页岩 润湿性 吸附量 吸附规律
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MG53通过调节NF-κB/Snail信号通路对子宫内膜损伤大鼠的影响
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作者 王欣欣 韩丽萍 +2 位作者 吴军卫 谢娅 郭瑞霞 《郑州大学学报(医学版)》 北大核心 2026年第2期66-70,共5页
目的:探讨MG53通过调节NF-κB/Snail信号通路对子宫内膜损伤大鼠的影响。方法:将36只雌性SD大鼠随机分为对照组、模型组、MG53组,每组12只。对照组用生理盐水冲洗腹腔后关腹,模型组采用搔刮和LPS损伤子宫内膜,MG53组造模后尾静脉注射MG... 目的:探讨MG53通过调节NF-κB/Snail信号通路对子宫内膜损伤大鼠的影响。方法:将36只雌性SD大鼠随机分为对照组、模型组、MG53组,每组12只。对照组用生理盐水冲洗腹腔后关腹,模型组采用搔刮和LPS损伤子宫内膜,MG53组造模后尾静脉注射MG53(每天4 mg/kg)。给药后第3天采用ELISA法检测子宫内膜组织匀浆中IL-6和TNF-α水平。给药后第14天采用HE染色和Masson染色观察内膜修复情况及纤维化程度;免疫荧光染色法检测子宫内膜组织中上皮标志物E-钙黏附蛋白(E-cadherin)、间质细胞标志物波形蛋白(Vimentin)、雌激素受体(ER)和孕激素受体(PR)表达;Western blot法检测子宫内膜组织中容受性指标整合素β3、白血病抑制因子及NF-κB/Snail信号通路中关键因子P65、p-P65和Snail蛋白表达。结果:与对照组比较,模型组子宫内膜组织匀浆中IL-6、TNF-α水平升高;子宫内膜厚度变薄,腺体减少,纤维化面积百分比升高;子宫内膜组织中E-cadherin、ER、PR、整合素β3和白血病抑制因子表达降低,p-P65/P65及Vimentin、Snail蛋白表达升高(P<0.01)。与模型组比较,MG53组上述指标变化趋势相反(P<0.01)。结论:MG53可通过调节NF-κB/Snail信号通路减轻炎症反应、抑制子宫内膜间质化、促进大鼠子宫内膜修复。 展开更多
关键词 MG53 NF-κB/Snail信号通路 子宫内膜损伤 大鼠
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丹参酮IIA基于NF-κB/TLR4信号通路对急性肺栓塞大鼠的作用研究
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作者 胡琼 鄢顺 +4 位作者 余倩 张昌志 韩婧 刘琳 刘维佳 《中国免疫学杂志》 北大核心 2026年第2期278-282,共5页
目的:探讨丹参酮IIA调控核因子-κB(NF-κB)/Toll样受体-4(TLR4)信号通路对急性肺栓塞(APE)大鼠的影响。方法:将42只SD大鼠随机抽取7只作为对照组,其余大鼠采用自体血栓复制法建立APE模型,将模型大鼠分为APE组,低分子肝素组(0.01 mL/kg... 目的:探讨丹参酮IIA调控核因子-κB(NF-κB)/Toll样受体-4(TLR4)信号通路对急性肺栓塞(APE)大鼠的影响。方法:将42只SD大鼠随机抽取7只作为对照组,其余大鼠采用自体血栓复制法建立APE模型,将模型大鼠分为APE组,低分子肝素组(0.01 mL/kg,皮下注射),丹参酮IIA低、中、高剂量组(4、8、16 mg/kg,腹腔注射),每组7只。建模1 h后对各组大鼠行肺动脉压(mPAP)、右心室压力(RVP)检测,建模3 h后处死大鼠并采集血清及肺组织标本,肺组织HE染色后行病理检查,ELISA检测大鼠血清TNF-α、IL-6、IL-1β、内皮素-1(ET-1)、一氧化氮(NO)水平,Western blot检测大鼠肺组织TLR4、NF-κB及核转录因子抑制蛋白α(IκBα)蛋白表达。结果:与对照组比较,APE组大鼠肺动脉腔内见血栓形成,肺泡内和间质水肿出血并伴有炎症细胞浸润,与APE组比较,丹参酮IIA各组随着剂量增加,炎症细胞浸润及病理损伤逐渐减轻。与对照组比较,APE组大鼠mPAP、RVP水平、血清TNF-α、IL-6、IL-1β、ET-1水平及肺组织TLR4、NF-κB蛋白表达显著升高,血清NO水平和肺组织IκBα蛋白表达降低(P<0.05)。与APE组比较,不同剂量丹参酮IIA组大鼠mPAP、RVP水平、血清TNF-α、IL-6、IL-1β、ET-1水平及肺组织TLR4、NF-κB蛋白表达显著降低,肺组织IκBα蛋白表达升高,且剂量越高,变化越显著(P<0.05)。结论:自体血栓复制法可成功建立APE大鼠模型,丹参酮IIA可减轻APE大鼠炎症反应,改善内皮细胞损伤,降低肺动脉压及右心室压,可能与调控TLR4/NF-κB通路,下调NF-κB、TLR4表达,上调IκBα表达有关。 展开更多
关键词 急性肺栓塞 丹参酮IIA NF-κB/TLR4信号通路
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基于TLR-4/MyD88/NF-κB信号通路探究温针灸干预膝骨关节炎的作用机制
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作者 王树东 董宝强 +5 位作者 盛泽伟 胡哲 于冬冬 王列 丁学峰 薛亚楠 《中华中医药学刊》 北大核心 2026年第2期24-27,I0008-I0012,共9页
目的基于Toll样受体-4(Toll-like receptors 4,TLR-4)/髓样分化因子88(Myeloid differentiation factor 88,MyD88)/核转录因子-κB(Nuclear transcription factor-kappa B,NF-κB)信号通路观察温针灸对膝骨关节炎(Knee osteoarthritis,K... 目的基于Toll样受体-4(Toll-like receptors 4,TLR-4)/髓样分化因子88(Myeloid differentiation factor 88,MyD88)/核转录因子-κB(Nuclear transcription factor-kappa B,NF-κB)信号通路观察温针灸对膝骨关节炎(Knee osteoarthritis,KOA)家兔模型的调控作用,探讨温针灸治疗膝骨关节炎的作用机制。方法健康大耳白兔40只,随机分为空白组、模型组、温针灸组、西药组,每组10只,以改良Hulth法建立膝骨关节炎模型,经4周干预后,随机处死两只,病理检查出现关节软骨表面不平整、炎性细胞浸润等改变即表明造模成功。采用HE染色法观察家兔膝关节形态学变化并进行光镜软骨检测评价标准(Mankin score,Mankin’s)评分;采用免疫组化法观察家兔膝关节软骨组织TLR-4、MyD88、NF-κB的表达,并进行半定量分析;采用酶联免疫吸附(Enzyme-linked immunosorbent assay,ELISA)法检测家兔血清中白细胞介素-6(Interleukin-6,IL-6)、白细胞介素-1β(Interleukin-1β,IL-1β)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)的含量;采用Wes全自动蛋白质印迹定量分析系统检测软骨组织TLR-4、MyD88、NF-κB的蛋白表达水平。结果HE染色可见空白组家兔膝关节软骨组织平整,无任何病理变化。模型组软骨组织表面粗糙,软骨细胞呈簇状堆积或减少。温针灸组以及西药组软骨组织表面欠平整,少量裂隙,伴有少量炎性细胞浸润。与空白组相比,模型组血清中IL-6、IL-1β、TNF-α含量显著升高(P<0.05),与模型组相比,温针灸组和西药组血清中IL-6、IL-1β、TNF-α含量显著下降(P<0.05);与空白组相比,模型组软骨组织TLR-4、MyD88、NF-κB蛋白表达显著升高(P<0.05),与模型组相比,温针灸组和西药组软骨组织TLR-4、MyD88、NF-κB蛋白表达显著下降(P<0.05),且温针灸组效果更为显著。结论温针灸可以通过抑制TLR-4/MyD88/NF-κB信号通路被激活,减少下游IL-6、IL-1β、TNF-α的含量以缓解炎症反应,延缓病程进展,达到治疗KOA的目的,并能够对软骨组织起到一定程度的修复作用。 展开更多
关键词 膝骨关节炎 温针灸 炎症反应 TLR-4 MYD88 NF-ΚB
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软坚散结胶囊介导炎症与血管新生通路抑制大肠癌生长的实验研究
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作者 许洁 侯桐欣 +2 位作者 侯佳宜 王晞星 高宇 《世界中医药》 北大核心 2026年第1期25-31,38,共8页
目的:明确软坚散结胶囊中药活性化学成分,以及其靶向肿瘤微环境达到治疗肠癌的目的。方法:采用质谱仪和化合物分析软件明确软坚散结胶囊的中药活性化学成分;利用鼠源肠癌CT26细胞建立肠癌荷瘤鼠模型,分为模型对照组,软坚散结低、中、高... 目的:明确软坚散结胶囊中药活性化学成分,以及其靶向肿瘤微环境达到治疗肠癌的目的。方法:采用质谱仪和化合物分析软件明确软坚散结胶囊的中药活性化学成分;利用鼠源肠癌CT26细胞建立肠癌荷瘤鼠模型,分为模型对照组,软坚散结低、中、高剂量组,分别予生理盐水和软坚散结低中高剂量灌胃,观察各组肿瘤体积,检测各组小鼠肠道肿瘤标志物、血管内皮生长因子(VEGF);免疫组织化学检测各组小鼠移植瘤组织中核因子κB(NF-κB)表达率及VEGF表达;检测荷瘤鼠肝功能、肾功能。结果:软坚散结胶囊质谱分析结果具有多种抗肿瘤的药理活性。与模型组比较,软坚散结低、中、高剂量组小鼠移植瘤体积、瘤重均低于模型组(P<0.05),消化道肿瘤标志物及VEGF低于模型组(P<0.05),移植瘤组织NF-κB及VEGF表达低于模型组(P<0.05),且均具有剂量依赖性;与模型组比较,各软坚散结组小鼠肝肾功能指标、体质量差异无统计学意义(P>0.05)。结论:软坚散结胶囊具有抗肿瘤活性,通过NF-κB、VEGF信号通路影响肠癌炎症及血管微环境干预肠癌生长,且安全性高。 展开更多
关键词 软坚散结胶囊 大肠癌 核因子ΚB 血管内皮生长因子 炎症 血管新生 肿瘤微环境
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生慧颗粒通过调控HMGB1/TLR4/NF-κB通路对AD模型小鼠认知功能及神经炎症的影响
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作者 陈雨萌 李非洲 +1 位作者 杨杰 王平 《世界科学技术-中医药现代化》 北大核心 2026年第2期611-620,共10页
目的 观察生慧颗粒对HMGB1/TLR4/NF-κB信号通路的影响,探讨生慧颗粒改善AD模型小鼠认知障碍的机制。方法 采用随机分组法将60只雄性C57BL/6品系小鼠(8周龄)分配至5个实验组,分别为空白对照组、模型组、生慧颗粒低剂量组(3.9 g/kg)、生... 目的 观察生慧颗粒对HMGB1/TLR4/NF-κB信号通路的影响,探讨生慧颗粒改善AD模型小鼠认知障碍的机制。方法 采用随机分组法将60只雄性C57BL/6品系小鼠(8周龄)分配至5个实验组,分别为空白对照组、模型组、生慧颗粒低剂量组(3.9 g/kg)、生慧颗粒高剂量组(7.8 g/kg)以及多奈哌齐组(0.65 mg/kg)。除空白组每日皮下注射生理盐水外,其余各组小鼠每日口服AlCl_(3)(20 mg/kg)和腹腔注射D-gal(120 mg/kg)8周,生慧颗粒组和多奈哌齐组自第5周开始,给予生慧颗粒和多奈哌齐灌胃4周,每日一次。运用Morris水迷宫检测学习记忆能力,HE染色观察海马CA3区病理变化,免疫组化检测海马CA3区Aβ_(1-42)蛋白表达,透射电镜观察海马神经元超微结构,ELISA检测脑组织中TNF-α、IL-6、IL-1β表达水平,免疫印迹检测HMGB1/TLR4/NF-κB通路蛋白表达水平。结果 与空白组小鼠比较,模型组小鼠的游泳总路程、平台潜伏期显著增加(P<0.01),穿越平台次数、目标象限停留时间均显著减少(P<0.01);模型组小鼠海马CA3区神经元密度显著降低,细胞排列稀疏,胞体结构异常,部分神经元出现核固缩,染色明显;神经元胞体结构受损,形态异常,核膜不完整,线粒体肿胀伴嵴结构紊乱或断裂,出现空泡样变;CA3区Aβ_(1-42)蛋白表达增多;脑组织中TNF-α、IL-6、IL-1β水平显著增高(P<0.01),HMGB1、TLR4、p-NF-κB p65/NF-κB p65蛋白表达差异显著升高(P<0.01)。与模型组小鼠比较,生慧颗粒组和多奈哌齐小鼠游泳总路程及平台潜伏期显著降低(P<0.01),穿越平台次数、目标象限停留时间显著增加(P<0.05,P<0.01);CA3区神经元数量增加,排列较有序且结构损伤改善;神经元结构现修复,核膜结构完整,线粒体肿胀程度减轻,空泡化现象明显改善;Aβ_(1-42)蛋白表达减少;脑组织中TNF-α、IL-6、IL-1β水平均显著降低(P<0.01),HMGB1、TLR4、p-NF-κB p65/NF-κB p65蛋白表达均显著降低(P<0.05)。结论 生慧颗粒可以通过抑制HMGB1/TLR4/NF-κB信号通路缓解AD病理,减轻神经炎症损伤,改善认知功能,且呈剂量依赖性。 展开更多
关键词 阿尔茨海默病 生慧颗粒 神经炎症 HMGB1/TLR4/NF-κB
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NF-κB在黏膜炎预防与治疗中的作用研究进展
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作者 冯永笑 张桂琼 +8 位作者 韩鹏炳 张强 董方 杨凯 张彦萍 崔阳阳 李凤菊 巨玉莲 高力英 《甘肃医药》 2026年第1期11-14,23,共5页
黏膜炎是癌症患者化疗和放疗的并发症之一,严重影响患者生活质量,目前仍无有效的治疗方法。近年来,细胞内信号通路为癌症治疗提供了研究方向。NF-κB信号通路是黏膜炎发生发展的主要节点,其表达与黏膜损伤密切相关,因此调节NF-κB活化... 黏膜炎是癌症患者化疗和放疗的并发症之一,严重影响患者生活质量,目前仍无有效的治疗方法。近年来,细胞内信号通路为癌症治疗提供了研究方向。NF-κB信号通路是黏膜炎发生发展的主要节点,其表达与黏膜损伤密切相关,因此调节NF-κB活化可能是临床治疗黏膜炎的有效策略,从而为有效靶向治疗和临床应用创造新方法。本文针对NF-κB这一潜在治疗靶点,系统综述其在化疗与放疗所致黏膜炎治疗中的作用及相关机制。 展开更多
关键词 黏膜炎 化疗 放疗 癌症 NF-ΚB 治疗靶点
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