Although notable progress has been made on novel cancer treatments,the overall survival rate and therapeutic effects are still unsatisfactory for cancer patients.Chemoimmunotherapy,combining chemotherapeutics and immu...Although notable progress has been made on novel cancer treatments,the overall survival rate and therapeutic effects are still unsatisfactory for cancer patients.Chemoimmunotherapy,combining chemotherapeutics and immunotherapeutic drugs,has emerged as a promising approach for cancer treatment,with the advantages of cooperating two kinds of treatment mechanism,reducing the dosage of the drug and enhancing therapeutic effect.Moreover,nano-based drug delivery system(NDDS)was applied to encapsulate chemotherapeutic agents and exhibited outstanding properties such as targeted delivery,tumor microenvironment response and site-specific release.Several nanocarriers have been approved in clinical cancer chemotherapy and showed significant improvement in therapeutic efficiency compared with traditional formulations,such as liposomes(Doxil R,Lipusu R),nanoparticles(Abraxane R)and micelles(Genexol-PM R).The applications of NDDS to chemoimmunotherapy would be a powerful strategy for future cancer treatment,which could greatly enhance the therapeutic efficacy,reduce the side effects and optimize the clinical outcomes of cancer patients.Herein,the current approaches of cancer immunotherapy and chemoimmunotherapy were discussed,and recent advances of NDDS applied for chemoimmunotherapy were further reviewed.展开更多
Atherosclerosis(AS), mainly caused by the changed immune system functions and inflammation, is the central pathogenesis of cardiovascular disease, which is a leading cause of death in the world. In modern medicine, th...Atherosclerosis(AS), mainly caused by the changed immune system functions and inflammation, is the central pathogenesis of cardiovascular disease, which is a leading cause of death in the world. In modern medicine, the development of carriers precisely delivering the therapeutic agents to the target sites is the primary goal, which could minimize the potential adverse effects and be more effective in treating lesions. Due to the precise location, real-time monitoring, AS microenvironment response, and low toxicity, stimuli-responsive nano-based drug delivery systems(NDDSs) have been a promising approach in AS treatments. Herein, we will systematically summarize the recent advances in stimuli-responsive NDDSs for AS treatment, including internal stimuli(reactive oxygen species, enzyme, shear stress, and pH) and external stimuli(light, ultrasound, and magnetism) responsive NDDSs. Besides, we will also summarize in detail the classification of stimuli-responsive NDDSs for AS, such as organic NDDSs(e.g., lipid-based and polymer-based nanomaterials), inorganic NDDSs(e.g., metal-based nanoparticles and nonmetallic nanomaterials), and composite multifunctional NDDSs. Finally, the critical challenges and prospects of this field will also be proposed and discussed.展开更多
Targeted protein degradation(TPD)technologies have emerged as a powerful strategy for eliminating disease-causing proteins by hijacking endogenous degradation systems.Over the past decade,multiple TPD modalities—such...Targeted protein degradation(TPD)technologies have emerged as a powerful strategy for eliminating disease-causing proteins by hijacking endogenous degradation systems.Over the past decade,multiple TPD modalities—such as proteolysis-targeting chimeras(PROTACs),molecular glues,lysosometargeting chimeras(LYTACs),autophagy-targeting chimeras(AUTACs),and others—have been developed to engage distinct cellular degradation pathways including the proteasome and lysosome systems.Despite their therapeutic promise,current TPD agents still face challenges of poor solubility,limited bioavailability,and inefficient delivery.To address these barriers,this review highlights the integration of nanotechnology with TPD as a promising approach.We summarize recent progress in proteasome-and lysosome-directed TPD strategies and describe how nanomaterials—including liposomes,polymers,inorganic nanoparticles,carbon dots,and ferritin—are applied to construct multivalent degraders,enhance pharmacokinetics,and demonstrate synergistic efficacy when combined with chemotherapy,immunotherapy,or catalytic therapies.In addition,we discuss the emerging convergence of nanozymes with TPD,where catalytic generation of reactive oxygen species not only regulates ubiquitination–deubiquitination balance but also facilitates endosomal disruption and boosts therapeutic efficacy.By bridging mechanistic innovation with nano-enabled platforms,nano-based TPD technologies offer enhanced precision,safety,and multifunctionality.Their continued advancement is poised to accelerate clinical translation and reshape strategies for treating complex and previously intractable diseases.展开更多
Polymeric nanomaterials,which have tuneable chemical structures,versatile functionalities,and good compatibility with polymeric matrices,have attracted increasing interest from researchers for the construction of poly...Polymeric nanomaterials,which have tuneable chemical structures,versatile functionalities,and good compatibility with polymeric matrices,have attracted increasing interest from researchers for the construction of polymeric nano-based separation membranes.With their distinctive nanofeatures,polymeric nano-based membranes show great promise in overcoming bottlenecks in polymer membranes,namely,the trade-off between permeability and selectivity,low stability,and fouling issues.Accordingly,recent studies have focused on tuning the structures and tailoring the surface properties of polymeric nano-based membranes via exploitation of membrane fabrication techniques and surface modification strategies,with the objective of pushing the performance of polymeric nano-based membranes to a new level.In this review,first,the approaches for fabricating polymeric nano-based mixed matrix membranes and homogeneous membranes are summarized,such as surface coating,phase inversion,interfacial polymerization,and self-assembly methods.Next,the manipulation strategies of membrane surface properties,namely,the hydrophilicity/hydrophobicity,charge characteristics,and surface roughness,and interior microstructural properties,namely,the pore size and content,channel construction and regulation,are comprehensively discussed.Subsequently,the separation performances of liquid ions/molecules and gas molecules through polymeric nano-based membranes are systematically reported.Finally,we conclude this review with an overview of various unsolved scientific and technical challenges that are associated with new opportunities in the development of advanced polymeric nano-based membranes.展开更多
Over the past decade,research has increasingly identified unique dysregulations in lipid metabolism within the tumor microenvironment(TME).Lipids,diverse biomolecules,not only constitute biological membranes but also ...Over the past decade,research has increasingly identified unique dysregulations in lipid metabolism within the tumor microenvironment(TME).Lipids,diverse biomolecules,not only constitute biological membranes but also function as signaling molecules and energy sources.Enhanced synthesis or uptake of lipids in the TME significantly promotes tumorigenesis and proliferation.Moreover,lipids secreted into the TME influence tumor-resident immune cells(TRICs),thereby aiding tumor survival against chemotherapy and immunotherapy.This review aims to highlight recent advancements in under-standing lipid metabolism in both tumor cells and TRICs,with a particular emphasis on exogenous lipid uptake and endogenous lipid de novo synthesis.Targeting lipid metabolism for intervention in anticancer therapies offers a promising therapeutic avenue for cancer treatment.Nano-drug delivery systems(NDDSs)have emerged as a means to maximize anti-tumor effects by rewiring tumor metabolism.This review provides a comprehensive overview of recent literature on the development of NDDSs targeting tumor lipid metabolism,particularly in the context of tumor immunotherapy.It covers four key aspects:reprogramming lipid uptake,reprogramming lipolysis,reshaping fatty acid oxidation(FAO),and reshuf-fing lipid composition on the cell membrane.The review concludes with a discussion of future prospects and challenges in this burgeoning field of research.展开更多
The emergence of COVID-19 has caused extensive harm and is recognized as a significant threat to human life worldwide. Currently, the application of nanomedicine techniques in pre-clinical studies related to various i...The emergence of COVID-19 has caused extensive harm and is recognized as a significant threat to human life worldwide. Currently, the application of nanomedicine techniques in pre-clinical studies related to various infections, such as respiratory viruses, herpes viruses, human papillomavirus, and HIV, has demonstrated success. Nanoparticles, due to their specific attributes, have garnered considerable attention in combating COVID-19. Strategies employing nanomaterials for COVID-19 prevention encompass the development of rapid, precise diagnostic tools, the creation of effective disinfectants, the delivery of mRNA vaccines to the biological system, and the administration of antiretroviral medications within the body. This article focuses on recent research regarding the effectiveness of nano platforms as antiviral measures against coronaviruses. It delves into the molecular characteristics of coronaviruses and the affected target systems, highlighting challenges and limitations in combating SARS-CoV-2. Additionally, it explores potential nanotechnology-based treatments to confront current and future variants of coronaviruses associated with COVID-19 infections.展开更多
基金supported by the National Natural Science Foundation of China(No.81974498,No.81773652)。
文摘Although notable progress has been made on novel cancer treatments,the overall survival rate and therapeutic effects are still unsatisfactory for cancer patients.Chemoimmunotherapy,combining chemotherapeutics and immunotherapeutic drugs,has emerged as a promising approach for cancer treatment,with the advantages of cooperating two kinds of treatment mechanism,reducing the dosage of the drug and enhancing therapeutic effect.Moreover,nano-based drug delivery system(NDDS)was applied to encapsulate chemotherapeutic agents and exhibited outstanding properties such as targeted delivery,tumor microenvironment response and site-specific release.Several nanocarriers have been approved in clinical cancer chemotherapy and showed significant improvement in therapeutic efficiency compared with traditional formulations,such as liposomes(Doxil R,Lipusu R),nanoparticles(Abraxane R)and micelles(Genexol-PM R).The applications of NDDS to chemoimmunotherapy would be a powerful strategy for future cancer treatment,which could greatly enhance the therapeutic efficacy,reduce the side effects and optimize the clinical outcomes of cancer patients.Herein,the current approaches of cancer immunotherapy and chemoimmunotherapy were discussed,and recent advances of NDDS applied for chemoimmunotherapy were further reviewed.
基金financial support from the Young Elite Scientists Sponsorship Program by Tianjin (No. 0701320001)Major Special Project of Tianjin (No. 0402080005)+1 种基金Program for Excellent Innovative Talents in Universities of Hebei Province (No. BJ2021019)Vietnam National University,Ho Chi Minh City (VNU-HCM,NCM2020-28-01)。
文摘Atherosclerosis(AS), mainly caused by the changed immune system functions and inflammation, is the central pathogenesis of cardiovascular disease, which is a leading cause of death in the world. In modern medicine, the development of carriers precisely delivering the therapeutic agents to the target sites is the primary goal, which could minimize the potential adverse effects and be more effective in treating lesions. Due to the precise location, real-time monitoring, AS microenvironment response, and low toxicity, stimuli-responsive nano-based drug delivery systems(NDDSs) have been a promising approach in AS treatments. Herein, we will systematically summarize the recent advances in stimuli-responsive NDDSs for AS treatment, including internal stimuli(reactive oxygen species, enzyme, shear stress, and pH) and external stimuli(light, ultrasound, and magnetism) responsive NDDSs. Besides, we will also summarize in detail the classification of stimuli-responsive NDDSs for AS, such as organic NDDSs(e.g., lipid-based and polymer-based nanomaterials), inorganic NDDSs(e.g., metal-based nanoparticles and nonmetallic nanomaterials), and composite multifunctional NDDSs. Finally, the critical challenges and prospects of this field will also be proposed and discussed.
基金financially supported by the National Natural Science Foundation of China(No.32000996)the Key Program of Nanozyme Laboratory in Zhongyuan(No.NLZ-KP2024NIC02)+1 种基金the Henan AIMS Professional Development Fund(No.JBKY250304)the Grant for International Joint Research Project of the Institute of Medical Science,the University of Tokyo(No.Extension-2019-K3005).
文摘Targeted protein degradation(TPD)technologies have emerged as a powerful strategy for eliminating disease-causing proteins by hijacking endogenous degradation systems.Over the past decade,multiple TPD modalities—such as proteolysis-targeting chimeras(PROTACs),molecular glues,lysosometargeting chimeras(LYTACs),autophagy-targeting chimeras(AUTACs),and others—have been developed to engage distinct cellular degradation pathways including the proteasome and lysosome systems.Despite their therapeutic promise,current TPD agents still face challenges of poor solubility,limited bioavailability,and inefficient delivery.To address these barriers,this review highlights the integration of nanotechnology with TPD as a promising approach.We summarize recent progress in proteasome-and lysosome-directed TPD strategies and describe how nanomaterials—including liposomes,polymers,inorganic nanoparticles,carbon dots,and ferritin—are applied to construct multivalent degraders,enhance pharmacokinetics,and demonstrate synergistic efficacy when combined with chemotherapy,immunotherapy,or catalytic therapies.In addition,we discuss the emerging convergence of nanozymes with TPD,where catalytic generation of reactive oxygen species not only regulates ubiquitination–deubiquitination balance but also facilitates endosomal disruption and boosts therapeutic efficacy.By bridging mechanistic innovation with nano-enabled platforms,nano-based TPD technologies offer enhanced precision,safety,and multifunctionality.Their continued advancement is poised to accelerate clinical translation and reshape strategies for treating complex and previously intractable diseases.
基金We are grateful for the financial support of the National Natural Science Foundation of China(Grants No.21376206,21306163,21676233,21776252 and 22125801).
文摘Polymeric nanomaterials,which have tuneable chemical structures,versatile functionalities,and good compatibility with polymeric matrices,have attracted increasing interest from researchers for the construction of polymeric nano-based separation membranes.With their distinctive nanofeatures,polymeric nano-based membranes show great promise in overcoming bottlenecks in polymer membranes,namely,the trade-off between permeability and selectivity,low stability,and fouling issues.Accordingly,recent studies have focused on tuning the structures and tailoring the surface properties of polymeric nano-based membranes via exploitation of membrane fabrication techniques and surface modification strategies,with the objective of pushing the performance of polymeric nano-based membranes to a new level.In this review,first,the approaches for fabricating polymeric nano-based mixed matrix membranes and homogeneous membranes are summarized,such as surface coating,phase inversion,interfacial polymerization,and self-assembly methods.Next,the manipulation strategies of membrane surface properties,namely,the hydrophilicity/hydrophobicity,charge characteristics,and surface roughness,and interior microstructural properties,namely,the pore size and content,channel construction and regulation,are comprehensively discussed.Subsequently,the separation performances of liquid ions/molecules and gas molecules through polymeric nano-based membranes are systematically reported.Finally,we conclude this review with an overview of various unsolved scientific and technical challenges that are associated with new opportunities in the development of advanced polymeric nano-based membranes.
基金National Natural Science Foundation of China(82174095,China)Natural Science Foundation of Zhejiang Province(LZ22H290001,China)Zhejiang Province Traditional Chinese Medicine Science and Technology Project(2023ZL362,China).
文摘Over the past decade,research has increasingly identified unique dysregulations in lipid metabolism within the tumor microenvironment(TME).Lipids,diverse biomolecules,not only constitute biological membranes but also function as signaling molecules and energy sources.Enhanced synthesis or uptake of lipids in the TME significantly promotes tumorigenesis and proliferation.Moreover,lipids secreted into the TME influence tumor-resident immune cells(TRICs),thereby aiding tumor survival against chemotherapy and immunotherapy.This review aims to highlight recent advancements in under-standing lipid metabolism in both tumor cells and TRICs,with a particular emphasis on exogenous lipid uptake and endogenous lipid de novo synthesis.Targeting lipid metabolism for intervention in anticancer therapies offers a promising therapeutic avenue for cancer treatment.Nano-drug delivery systems(NDDSs)have emerged as a means to maximize anti-tumor effects by rewiring tumor metabolism.This review provides a comprehensive overview of recent literature on the development of NDDSs targeting tumor lipid metabolism,particularly in the context of tumor immunotherapy.It covers four key aspects:reprogramming lipid uptake,reprogramming lipolysis,reshaping fatty acid oxidation(FAO),and reshuf-fing lipid composition on the cell membrane.The review concludes with a discussion of future prospects and challenges in this burgeoning field of research.
文摘The emergence of COVID-19 has caused extensive harm and is recognized as a significant threat to human life worldwide. Currently, the application of nanomedicine techniques in pre-clinical studies related to various infections, such as respiratory viruses, herpes viruses, human papillomavirus, and HIV, has demonstrated success. Nanoparticles, due to their specific attributes, have garnered considerable attention in combating COVID-19. Strategies employing nanomaterials for COVID-19 prevention encompass the development of rapid, precise diagnostic tools, the creation of effective disinfectants, the delivery of mRNA vaccines to the biological system, and the administration of antiretroviral medications within the body. This article focuses on recent research regarding the effectiveness of nano platforms as antiviral measures against coronaviruses. It delves into the molecular characteristics of coronaviruses and the affected target systems, highlighting challenges and limitations in combating SARS-CoV-2. Additionally, it explores potential nanotechnology-based treatments to confront current and future variants of coronaviruses associated with COVID-19 infections.
