Chinese cabbage(Brassica rapa subsp.pekinensis)is a widely cultivated vegetable crop in Asia with significant economic importance(Li et al.,2024;Yu et al.,2024).As a potyvirus with the broad host range,turnip mosaic v...Chinese cabbage(Brassica rapa subsp.pekinensis)is a widely cultivated vegetable crop in Asia with significant economic importance(Li et al.,2024;Yu et al.,2024).As a potyvirus with the broad host range,turnip mosaic virus(TuMV)is a major pathogen affecting Chinese cabbages,leading to severe yield losses(Li et al.,2019).Traditional control measures have shown limited efficacy,and the long-term use of chemical pesticides has led to significant issues such as environmental pollution and pathogen resistance(Samara et al.,2021;Lu et al.,2022).Biologicallyderived pesticides have garnered considerable attention owing to their eco-friendly attributes(Ayilara et al.,2023).γ-Aminobutyric acid(GABA),initially discovered in potato tubers,has been proven to regulate immune responses and enhance resistance to fungal and bacterial pathogens by modulating reactive oxygen species and stress-related hormone signals(Tarkowski et al.,2020;Wang et al.,2025).But biologically-derived agents typically face challenges such as large particle size and instability,which limit their practical application and bioavailability(Daraban et al.,2023).展开更多
Neem(Azadirachta indica A.Juss),prominently known as conventional medication is a local plant in India.Neem is regarded as a promising tree species which can be utilized in variety ways to benefit agricultural communi...Neem(Azadirachta indica A.Juss),prominently known as conventional medication is a local plant in India.Neem is regarded as a promising tree species which can be utilized in variety ways to benefit agricultural communities throughout the world.Neem based insect sprays were productive for the control of different insect species,yet their low lingering impact and absence of normalized definitions are issues for field application.Additionally,neem is fairly have harmful impact in nature.The use of nanotechnology as a mean for nanopesticides is in the beginning time of improvement.All things considered,the nanosphere definition demonstrated upgraded systemicity of the dynamic fixings and made its infiltration better in the plant,because of their little size.Nanoencapsulated pesticides can give controlled discharge energy,while proficiently upgrading piousness,dependability,and solvency.Nanoencapsulation can improve the vermin control proficiency over expanded spans by forestalling debasement of dynamic fixings under ecological conditions.This survey is hence composed to fundamentally evaluate the toxicological impacts i.e to examine the manifestations,systems and identifications of poisoning vertebrates particularly people.The prepared neem nano-plants contrasted with the bulk one have will be assessed on albino mice through two main approaches,i.e.determination of acute oral LD50 and study the toxic effect of sublethal dose(LD10)on some biochemical parameters.The effect of the prepared nano-formulations compared to the bulk one on various biomarkers,i.e.hematological,hepatotoxicity and nephrotoxicity in albino mice after an oral administration of sub-lethal dose during sub-acute treatment were taken in consideration.Hence,this review should thus offer an important guide for building up potential advantages are underlined,while little is known on security or the antagonistic impacts of nanoadvances in the agro-foodsystem.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.32402564,32330096,32372631)Hebei Natural Science Foundation(Grant No.C2024204246)+1 种基金the Pinduoduo-China Agricultural University Research Fund(Grant No.PC2023B02018)the 2115 Talent Development Program of China Agricultural University.
文摘Chinese cabbage(Brassica rapa subsp.pekinensis)is a widely cultivated vegetable crop in Asia with significant economic importance(Li et al.,2024;Yu et al.,2024).As a potyvirus with the broad host range,turnip mosaic virus(TuMV)is a major pathogen affecting Chinese cabbages,leading to severe yield losses(Li et al.,2019).Traditional control measures have shown limited efficacy,and the long-term use of chemical pesticides has led to significant issues such as environmental pollution and pathogen resistance(Samara et al.,2021;Lu et al.,2022).Biologicallyderived pesticides have garnered considerable attention owing to their eco-friendly attributes(Ayilara et al.,2023).γ-Aminobutyric acid(GABA),initially discovered in potato tubers,has been proven to regulate immune responses and enhance resistance to fungal and bacterial pathogens by modulating reactive oxygen species and stress-related hormone signals(Tarkowski et al.,2020;Wang et al.,2025).But biologically-derived agents typically face challenges such as large particle size and instability,which limit their practical application and bioavailability(Daraban et al.,2023).
文摘Neem(Azadirachta indica A.Juss),prominently known as conventional medication is a local plant in India.Neem is regarded as a promising tree species which can be utilized in variety ways to benefit agricultural communities throughout the world.Neem based insect sprays were productive for the control of different insect species,yet their low lingering impact and absence of normalized definitions are issues for field application.Additionally,neem is fairly have harmful impact in nature.The use of nanotechnology as a mean for nanopesticides is in the beginning time of improvement.All things considered,the nanosphere definition demonstrated upgraded systemicity of the dynamic fixings and made its infiltration better in the plant,because of their little size.Nanoencapsulated pesticides can give controlled discharge energy,while proficiently upgrading piousness,dependability,and solvency.Nanoencapsulation can improve the vermin control proficiency over expanded spans by forestalling debasement of dynamic fixings under ecological conditions.This survey is hence composed to fundamentally evaluate the toxicological impacts i.e to examine the manifestations,systems and identifications of poisoning vertebrates particularly people.The prepared neem nano-plants contrasted with the bulk one have will be assessed on albino mice through two main approaches,i.e.determination of acute oral LD50 and study the toxic effect of sublethal dose(LD10)on some biochemical parameters.The effect of the prepared nano-formulations compared to the bulk one on various biomarkers,i.e.hematological,hepatotoxicity and nephrotoxicity in albino mice after an oral administration of sub-lethal dose during sub-acute treatment were taken in consideration.Hence,this review should thus offer an important guide for building up potential advantages are underlined,while little is known on security or the antagonistic impacts of nanoadvances in the agro-foodsystem.
