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Cooperative robust parallel operation of multiple actuators
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作者 XU Liang XU Xiang LIU Tao 《控制理论与应用》 北大核心 2026年第1期3-11,共9页
This paper studies cooperative robust parallel operation of multiple actuators over an undirected communication graph.The plant is modeled as an uncertain linear system,and the actuators are linear and identical.Based... This paper studies cooperative robust parallel operation of multiple actuators over an undirected communication graph.The plant is modeled as an uncertain linear system,and the actuators are linear and identical.Based on the internal model principle,a distributed dynamic output feedback control law is proposed to achieve both robust output regulation of the closed-loop system and plant input sharing among the actuators.A practical example of five motors cooperatively driving an uncertain shaft under an external load torque is presented to show the effectiveness of the proposed control law. 展开更多
关键词 cooperative parallel operation multiple actuators robust output regulation CONSENSUS
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Role of Multiscale Interactions within the Westerly Wind Bursts in MJO Prediction
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作者 Jian LING Yuanwen ZHANG Chongyin LI 《Advances in Atmospheric Sciences》 2026年第3期489-503,共15页
This study reveals the critical role of multiscale interaction within the westerly wind bursts(WWBs)west of the MJO convection in modulating the prediction skill for the November MJO event during the DYNAMO(Dynamics o... This study reveals the critical role of multiscale interaction within the westerly wind bursts(WWBs)west of the MJO convection in modulating the prediction skill for the November MJO event during the DYNAMO(Dynamics of the Madden–Julian Oscillation)field campaign.The characteristics of the MJO convection envelope are obtained by the largescale precipitation tracking method,and a novel metric is introduced to quantify the prediction skill for the MJO convection in the ECMWF reforecast.The ECMWF forecast exhibits approximately 17 days in skillful prediction for the MJO convection—significantly lower than that derived from the global measure.The reforecast ensembles are further classified into high and low skill catalogs based on the mean prediction skill during the observed WWBs period.High-skill ensembles exhibit significantly enhanced low-level westerlies,amplified MJO convection,and reduced spatial separation between the low-level westerlies and MJO convection during the WWBs period,indicating stronger coupling between the large-scale circulation and the convection.Mechanistic analysis reveals that enhanced westerlies in high-skill ensembles can transfer more high-frequency energy to the MJO convection through the flux convergence of interaction energy for MJO convection development,resulting in better prediction skill. 展开更多
关键词 MJO convection envelope PREDICTION multiscale interaction
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Multi-Area Path Planning for Multiple Unmanned Surface Vessels
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作者 Jianing Wu Yufeng Chen +2 位作者 Li Yin Huajun He Panshuan Jin 《Computers, Materials & Continua》 2026年第4期1093-1110,共18页
To conduct marine surveys,multiple unmanned surface vessels(Multi-USV)with different capabilities perform collaborative mapping in multiple designated areas.This paper proposes a task allocation algorithm based on int... To conduct marine surveys,multiple unmanned surface vessels(Multi-USV)with different capabilities perform collaborative mapping in multiple designated areas.This paper proposes a task allocation algorithm based on integer linear programming(ILP)with flow balance constraints,ensuring the fair and efficient distribution of sub-areas among USVs and maintaining strong connectivity of assigned regions.In the established gridmap,a search-based path planning algorithm is performed on the sub-areas according to the allocation scheme.It uses the greedy algorithm and the A*algorithm to achieve complete coverage of the barrier-free area and obtain an efficient trajectory of each USV.The greedy algorithm enables fast local traversal of unvisited grids,while the A*algorithm ensures navigation to escape from deadlock areas and maintains global path continuity.The comparison of task allocation results proves that the task allocation algorithm based on ILP improves the mapping efficiency and task distribution fairness.The proposed allocation method and result analysis provide a certain reference for the practical application ofMulti-USV to perform survey tasks collaboratively. 展开更多
关键词 multiple unmanned surface vessels multiple areas integer linear programming
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Illusion of inactivity:Revisiting progressive multiple sclerosis treatment paradigms
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作者 Tal Ganz Tamir Ben-Hur 《Neural Regeneration Research》 2026年第3期1134-1135,共2页
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v... Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven. 展开更多
关键词 inflammatory versus degenerative dichotomythis treatment paradigms illusion inactivity multiple sclerosis traditionallythe central nervous system cns which progressive multiple sclerosis active inflammation progressive multiple sclerosis pms
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Impact of multiscale flow structures on mixing and losses in turbine blade tip region
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作者 Zhengping ZOU Lin HUANG Yifan WANG 《Chinese Journal of Aeronautics》 2026年第2期44-79,共36页
Multiscale mixing of the turbine blade tip leakage and mainstream flows causes considerable aerodynamic loss.Understanding it is crucial to correctly estimating the mixing loss and thus improving the turbine's per... Multiscale mixing of the turbine blade tip leakage and mainstream flows causes considerable aerodynamic loss.Understanding it is crucial to correctly estimating the mixing loss and thus improving the turbine's performance.The multiscale mixing phenomenon in a typical high-pressure turbine rotor flow was studied in this work.The contributions of various scale flows to entropy production and mixing properties were identified.The corresponding physical mechanisms at different scales were explored.It is shown that the large-scale and time-averaged flow contributions to mixing are significant,accounting for approximately 37.1% and 25% of the total.Time-averaged and large-scale flows cause the majority of the fluid deformation of the material surface,while mesoand small-scale flows just generate finer deformations.It raises the area stretch coefficient and the virtual concentration gradient.Thus,mixing is enhanced.Furthermore,time-averaged and large-scale flows account for the majority of the losses in the upstream and downstream regions of the blade tip respectively,accounting for approximately 53.8%and 33.5%of the total.The sheet-like structures—rather than the tip leaking vortex—are the primary source of the loss.High-dissipation regions are produced by the sheet-like structures via the pressure Hessian term and the self-amplification terms. 展开更多
关键词 Entropy production analysis MIXING multiscale flows Tip leakage flow TURBINE
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Steel Surface Defect Detection via the Multiscale Edge Enhancement Method
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作者 Yuanyuan Wang Yemeng Zhu +2 位作者 Xiuchuan Chen Tongtong Yin Shiwei Su 《Computers, Materials & Continua》 2026年第3期1006-1032,共27页
To solve the false detection and missed detection problems caused by various types and sizes of defects in the detection of steel surface defects,similar defects and background features,and similarities between differ... To solve the false detection and missed detection problems caused by various types and sizes of defects in the detection of steel surface defects,similar defects and background features,and similarities between different defects,this paper proposes a lightweight detection model named multiscale edge and squeeze-and-excitation attention detection network(MSESE),which is built upon the You Only Look Once version 11 nano(YOLOv11n).To address the difficulty of locating defect edges,we first propose an edge enhancement module(EEM),apply it to the process of multiscale feature extraction,and then propose a multiscale edge enhancement module(MSEEM).By obtaining defect features from different scales and enhancing their edge contours,the module uses the dual-domain selection mechanism to effectively focus on the important areas in the image to ensure that the feature images have richer information and clearer contour features.By fusing the squeeze-and-excitation attention mechanism with the EEM,we obtain a lighter module that can enhance the representation of edge features,which is named the edge enhancement module with squeeze-and-excitation attention(EEMSE).This module was subsequently integrated into the detection head.The enhanced detection head achieves improved edge feature enhancement with reduced computational overhead,while effectively adjusting channel-wise importance and further refining feature representation.Experiments on the NEU-DET dataset show that,compared with the original YOLOv11n,the improved model achieves improvements of 4.1%and 2.2%in terms of mAP@0.5 and mAP@0.5:0.95,respectively,and the GFLOPs value decreases from the original value of 6.4 to 6.2.Furthermore,when compared to current mainstream models,Mamba-YOLOT and RTDETR-R34,our method achieves superior performance with 6.5%and 8.9%higher mAP@0.5,respectively,while maintaining a more compact parameter footprint.These results collectively validate the effectiveness and efficiency of our proposed approach. 展开更多
关键词 Steel defects object detection algorithms small target multiscale attention mechanism
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GLMCNet: A Global-Local Multiscale Context Network for High-Resolution Remote Sensing Image Semantic Segmentation
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作者 Yanting Zhang Qiyue Liu +4 位作者 Chuanzhao Tian Xuewen Li Na Yang Feng Zhang Hongyue Zhang 《Computers, Materials & Continua》 2026年第1期2086-2110,共25页
High-resolution remote sensing images(HRSIs)are now an essential data source for gathering surface information due to advancements in remote sensing data capture technologies.However,their significant scale changes an... High-resolution remote sensing images(HRSIs)are now an essential data source for gathering surface information due to advancements in remote sensing data capture technologies.However,their significant scale changes and wealth of spatial details pose challenges for semantic segmentation.While convolutional neural networks(CNNs)excel at capturing local features,they are limited in modeling long-range dependencies.Conversely,transformers utilize multihead self-attention to integrate global context effectively,but this approach often incurs a high computational cost.This paper proposes a global-local multiscale context network(GLMCNet)to extract both global and local multiscale contextual information from HRSIs.A detail-enhanced filtering module(DEFM)is proposed at the end of the encoder to refine the encoder outputs further,thereby enhancing the key details extracted by the encoder and effectively suppressing redundant information.In addition,a global-local multiscale transformer block(GLMTB)is proposed in the decoding stage to enable the modeling of rich multiscale global and local information.We also design a stair fusion mechanism to transmit deep semantic information from deep to shallow layers progressively.Finally,we propose the semantic awareness enhancement module(SAEM),which further enhances the representation of multiscale semantic features through spatial attention and covariance channel attention.Extensive ablation analyses and comparative experiments were conducted to evaluate the performance of the proposed method.Specifically,our method achieved a mean Intersection over Union(mIoU)of 86.89%on the ISPRS Potsdam dataset and 84.34%on the ISPRS Vaihingen dataset,outperforming existing models such as ABCNet and BANet. 展开更多
关键词 multiscale context attention mechanism remote sensing images semantic segmentation
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Impact of machine learning-driven analysis of blood transcriptomes in multiple sclerosis
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作者 Alessandro Digilio Cinthia Farina 《Neural Regeneration Research》 2026年第8期3557-3558,共2页
Multiple sclerosis(MS)is a chronic disorder of the central nervous system characterized by multifocal lesions where inflammation,demyelination,and neurodegeneration occur(Jakimovski et al.,2024).MS diagnosis primarily... Multiple sclerosis(MS)is a chronic disorder of the central nervous system characterized by multifocal lesions where inflammation,demyelination,and neurodegeneration occur(Jakimovski et al.,2024).MS diagnosis primarily relies on the demonstration of dissemination in time and space of the lesions based on clinical,magnetic resonance imaging(MRI),and cerebrospinal fluid assessments(Jakimovski et al.,2024). 展开更多
关键词 multifocal lesions INFLAMMATION cerebrospinal fluid assessments jakimovski blood transcriptomes DIAGNOSIS multiple sclerosis ms multiple sclerosis resonance imaging mri
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Antigen presentation at the brain barriers in multiple sclerosis
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作者 Joshua Brands Jeroen Bogie Bieke Broux 《Neural Regeneration Research》 2026年第7期2932-2933,共2页
Loss of immune tolerance to central nervous system(CNS)antigens lies at the heart of multiple sclerosis(MS),the most common chronic autoimmune disease of the CNS.MS affects nearly2 million people wo rldwide and is cha... Loss of immune tolerance to central nervous system(CNS)antigens lies at the heart of multiple sclerosis(MS),the most common chronic autoimmune disease of the CNS.MS affects nearly2 million people wo rldwide and is chara cterized by focal areas of demyelination,inflammation,axonal injury,and neurodegeneration(Bronge et al.,2022;Magliozzi et al.,2023). 展开更多
关键词 brain barriers central nervous system antigen presentation multiple sclerosis loss immune tolerance loss immune multiple sclerosis ms chronic autoimmune disease
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Multiscale characterization of shale softening induced by water-based fluids
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作者 Jianting Du Andrew J.Whittle +2 位作者 Liming Hu Thibaut Divoux Jay N.Meegoda 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第3期1830-1841,共12页
Characterization of mechanical alterations of shale constituent phases is critical for an in-depth understanding of the underlying mechanisms of shale softening.In this study,a hydro-thermal reaction system is set up ... Characterization of mechanical alterations of shale constituent phases is critical for an in-depth understanding of the underlying mechanisms of shale softening.In this study,a hydro-thermal reaction system is set up to mimic the interactions between shale and water-based fluids under the subsurface environment in shale formations.Using a coupled analysis of grid nanoindentation and in situ mineralogical identification,mechanical alterations of shale constituent mineral phases are revealed.Mechanical degradation of carbonate and clay phases is 10 times greater than quartz,pyrite and organic phases.The KCl additive greatly mitigates mechanical degradation of the clay phase.The high temperature and pressure results in a mechanical degradation of carbonate minerals as much as three times of that occurs at room temperature and atmospheric pressure.Multiscale mechanical models,which are established based on Mori-Tanaka(MT)and self-consistent(SC)schemes,predict more accurate elastic softening of shale composite than the microindentation experiments,due to the microcracks generated in the experiments.Based on the calculation of the multiscale mechanical model,under the subsurface environment of shale formations(e.g.80℃ and 8 MPa),the carbonate dissolution leads to a reduction in Young's modulus of shale composite by about 30%,while the degradation of clay minerals only causes a reduction by up to 9%. 展开更多
关键词 Grid nanoindentation Hydro-thermal treatment Morphological and mineralogical identification multiscale mechanical model Shale softening
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Durable and Crack-Resistant Dual-Network C-Lignin-Based Triboelectric Materials Enabled by Multiscale Crosslinking Strategy for Gait Monitoring and Identification
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作者 Boyu Du Jiajun Zhang +6 位作者 Yuxin Yang Tian Tang Yuwen Wang Yuxuan Xie Xing Wang Ting Xu Chuanling Si 《Aggregate》 2026年第2期283-298,共16页
With the continuous advancement of social technology and the increasing awareness of health management,biomass-based triboelectric nanogenerator(TENG)displayed significant potential as flexible wearable electronics fo... With the continuous advancement of social technology and the increasing awareness of health management,biomass-based triboelectric nanogenerator(TENG)displayed significant potential as flexible wearable electronics for continuous foot gait monitoring.Nevertheless,existing biomass-based TENG often faces challenges of insufficient mechanical robustness and durability in practical applications,where they are prone to surface abrasion and structural fracture under continuous compression and friction,severely limiting their long-term performances.In order to address these challenges,this work proposed a multiscale crosslinking strategy,which strengthened the noncovalent interactions within the polymer by constructing multiple reinforcement networks,successfully fabricating a dual-network C-lignin-based triboelectric material(CLTM)with excellent durability and crack resistance.Among them,the optimal CLTM(PSGCL-0.2)exhibited high mechanical strength(strain 445%,tensile strength 41.56 MPa,Young's modulus 41.25 MPa,toughness 159.67 MJ/m^(3))and excellent cyclic stability(300 cycles)with versatile functionalities,including antibacterial,antioxidant,and UV-shielding properties,water stabilization(255.51 g/m^(2)/d),efficient photothermal conversion,and full recyclability.Furthermore,biomass-based TENG device assembled from PSGCL-0.2 achieved stable triboelectric output properties(102.5 V,2.9μA,and 61.3 nC),and sustainable for 2000 cycles,fast response time(68 ms),and excellent power density(325.9 mW/m^(2)),effectively converting mechanical energy into electrical energy.Especially,PSGCL 0.2 was also integrated into the wireless self-powered smart insole,successfully enabling real-time visual monitoring of plantar pressure distribution and dynamic gait.Meanwhile,combined with the machine learning algorithm,the self-powered smart insole achieved precise recognition and classification of eight different motion states with an accuracy of 98%.This study provides the feasible strategy for developing extremely stable and durable biomass-based TENG,aimed at advancing sustainable intelligent healthcare systems. 展开更多
关键词 C-lignin gait monitoring and identification machine learning multiscale crosslinking self-powered triboelectric material
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Arginine-derived inhibitor-based anticorrosion coating for carbon steel in 3-nitro-1,2,4-triazol-5-one (NTO) medium: Integration of experimental and multiscale simulations
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作者 Ziyang Guo Zhe Zhang +3 位作者 Shuai Zhao Manman Wang Yujie Qiang Qinghai Shu 《Defence Technology(防务技术)》 2026年第3期307-322,共16页
As a representative insensitive high explosive,3-nitro-1,2,4-triazol-5-one(NTO)has garnered significant attention due to its ability to substantially reduce the risk of accidental detonation in munitions.However,its i... As a representative insensitive high explosive,3-nitro-1,2,4-triazol-5-one(NTO)has garnered significant attention due to its ability to substantially reduce the risk of accidental detonation in munitions.However,its inherent acidity induces severe interfacial corrosion of metal casings,thereby limiting its engineering applications.Based on the micro-corrosion mechanism of NTO on carbon steel(CS),this study designs an arginine-derived corrosion inhibitor,N2-[(phenylamino)thioxomethyl]-arginine(PTA).Electrochemical tests reveal that PTA exhibits an outstanding corrosion inhibition efficiency of 98.0%in NTO solution.Density functional theory(DFT)and molecular dynamics(MD)simulations elucidate the inhibition mechanism of PTA,demonstrating that it not only co-adsorbs with NTO^(−) onto the CS surface to form a dense and stable protective film but also disrupts the strong interactions between NTO^(−) and Fe,thereby suppressing nitro group-induced reduction,decomposition,and excessive surface oxidation.Furthermore,a PTA-loaded mesoporous silica(mSiO_(2))nanoparticles(NPs)-reinforced epoxy resin(EP)composite coating was constructed.Benefiting from the enhanced barrier properties of PTA@mSiO_(2) NPs and the synergistic effect between PTA and NTO^(−),the low-frequency impedance of the composite coating remained as high as 1.29×10^(9)Ω·cm^(2) after 30 days of immersion in NTO solution,exhibiting a two-order-of-magnitude improvement compared to the pure EP coating.This study proposes an effective corrosion control strategy to mitigate NTO-induced corrosion,providing insights into the development of advanced corrosion protection strategies for broader applications. 展开更多
关键词 Carbon steel 3-Nitro-1 2 4-triazol-5-one Corrosion inhibitor Composite coating multiscale simulations
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Formation control for multiple spacecraft with disturbances and sensor failures
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作者 LI Yufei LYU Yuezu PENG Wenliang 《Journal of Systems Engineering and Electronics》 2026年第1期18-25,共8页
Formation control of multiple spacecraft has attracted extensive research attention.However,achieving reliable performance under sensor failures remains a significant challenge.This paper develops an integrated framew... Formation control of multiple spacecraft has attracted extensive research attention.However,achieving reliable performance under sensor failures remains a significant challenge.This paper develops an integrated framework that jointly designs distributed observers and local controllers to ensure robust formation control in the presence of external disturbances and sensor malfunctions.Treating the spacecraft formation as a single interconnected system,each spacecraft constructs a distributed observer that estimates the overall system state by incorporating both its own measurements and the predicted control information shared among the spacecraft.Based on the observer estimates,a local control law is synthesized to maintain the desired formation.Rigorous theoretical analysis and numerical simulations demonstrate that the proposed integrated approach effectively guarantees formation stability and resilience against sensor failures and disturbances. 展开更多
关键词 formation control multiple spacecraft DISTURBANCE sensor failure
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Field Application of SeMNPV(Spodoptera exigua Multiple Nucleopolyhedrovirus)for Controlling Spodoptera exigua on Shallot and Scallion in the Mekong Delta,Vietnam
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作者 Xuan Trinh Thi Lien Truong Thanh Xuan Son Pham Kim 《Research in Ecology》 2026年第1期40-51,共12页
Shallot and scallion are among the essential horticultural crops in the Mekong Delta of Vietnam,and their yields and quality are affected by the beet armyworm,Spodoptera exigua.To control this pest,farmers have used a... Shallot and scallion are among the essential horticultural crops in the Mekong Delta of Vietnam,and their yields and quality are affected by the beet armyworm,Spodoptera exigua.To control this pest,farmers have used a large number of insecticides,which has led to resistance due to continuous use and environmental harm,thereby increasing interest in biological methods,including the Spodoptera exigua multiple nucleopolyhedrovirus(SeMNPV).The study aims to assess the efficacy of the liquid and powder formulation of SeMNPV against Spodoptera exigua under the actual agricultural conditions of Soc Trang(Shallot)and Vinh Long provinces(Scallion).The experimental arrangement used four treatments:SeMNPV liquid,SeMNPV powder,Radiant 60SC(a chemical insecticide),and the control.Some of the factors evaluated were larval density,level of leaf damage,yield,and natural enemies attack.The SeMNPV powder had the least damage,only 0.97 per cent(damage of plant),and a yield of 28.59 t/ha,and was almost equally good as the Radiant 60SC,which produced a damage of 2.53 per cent(damage of plant)and a yield of 29.41 t/ha.SeMNPV treatments significantly reduced larval numbers(down to fewer than 10 larvae/m2 by day 40)and enhanced natural enemies,parasitoids,and microsporidia.The untreated one had the highest damage(8.03%),while the yield was lowest at 19.61 t/ha.Therefore,SeMNPV in powder form has the potential to control S.exigua infestations and to encourage biological control,making it a favourable,environmentally friendly addition to synthetic insecticides in the cultivation of shallot and scallion. 展开更多
关键词 Beet Armyworm Spodoptera exigua multiple Nucleopolyhedrovirus SHALLOT Scallion
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FIXED-TIME PASSIVITY AND SYNCHRONIZATION OF SPATIOTEMPORAL DIRECTED NETWORKS WITH MULTIPLE WEIGHTS
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作者 Yujie MA Cheng HU Leimin WANG 《Acta Mathematica Scientia》 2026年第1期361-382,共22页
This paper is dedicated to fixed-time passivity and synchronization for multi-weighted spatiotemporal directed networks.First,to achieve fixed-time passivity,a type of decentralized power-law controller is developed,i... This paper is dedicated to fixed-time passivity and synchronization for multi-weighted spatiotemporal directed networks.First,to achieve fixed-time passivity,a type of decentralized power-law controller is developed,in which only one parameter needs to be adjusted in the power-law terms;this greatly decreases the inconvenience of parameter adjustment.Second,several fixed-time passivity criteria with LMI forms are derived by using a Gauss divergence theorem to deal with the spatial diffusion of nodes and by applying the Hölder’s inequality to dispose rigorously the power-law term greater than one in the designed control scheme;this improves the previous theoretical analysis.Additionally,the fixed-time synchronization of spatiotemporal directed networks with multi-weights is addressed as a direct result of fixed-time strict passivity.Finally,a numerical example is presented in order to show the validity of the theoretical analysis. 展开更多
关键词 fixed-time passivity fixed-time synchronization spatiotemporal networks multiple weights directed topology
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The adhesive interlayer effect on the thermoelectric structure with multiple electrodes
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作者 Xiaojuan TIAN Yueting ZHOU 《Applied Mathematics and Mechanics(English Edition)》 2026年第3期573-598,共26页
Driven by the trend of device miniaturization and high-density integration,the interaction between adjacent electrodes has become a critical factor affecting the interfacial reliability of thermoelectric(TE)structures... Driven by the trend of device miniaturization and high-density integration,the interaction between adjacent electrodes has become a critical factor affecting the interfacial reliability of thermoelectric(TE)structures.This study investigates the influence of adjoining electrode interactions on the interfacial response of a multi-electrode/TE substrate structure,including interfacial stresses and stress intensity factors at the electrode ends.To solve the corresponding boundary-value problem,the Fourier transforms are adopted to derive a governing integro-differential equation for the interfacial shear stress in multi-electrode systems,incorporating the TE effects as generalized forces on the right-hand side.The results show that both the interfacial tension and transverse stress in the electrodes are significantly affected by the presence of adjacent electrodes.The interaction between neighboring electrodes diminishes as their spacing increases or when an adhesive interlayer is introduced.Furthermore,the softer and thinner electrodes,the softer and thicker adhesive interlayer,and the smaller TE loads are found to be beneficial for improving the interfacial performance.These findings may contribute to the accurate measurement in surface sensors and layout design of multi-point health monitoring systems for TE structures. 展开更多
关键词 thermoelectric(TE)material multiple electrodes adhesive interlayer interface behavior
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Predicting lymph node metastasis in colorectal cancer using caselevel multiple instance learning
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作者 Ling-Feng Zou Xuan-Bing Wang +4 位作者 Jing-Wen Li Xin Ouyang Yi-Ying Luo Yan Luo Cheng-Long Wang 《World Journal of Gastroenterology》 2026年第1期110-125,共16页
BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning ofte... BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation. 展开更多
关键词 Colorectal cancer Lymph node metastasis Deep learning multiple instance learning HISTOPATHOLOGY
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Retinal layers thickness and retinal vascular parameters in patients with multiple sclerosis
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作者 Mehdi Moghaddasi Mahsa Sardarinia +3 位作者 Mostafa Soltansanjari Ahmad Vafajoo Nafise Mohebi Simin Zare 《国际眼科杂志》 2026年第3期368-374,共7页
AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patie... AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patients diagnosed with MS and a control group of 43 healthy hospital staff matched in terms of age and sex at Iran University,department of neurology and ophthalmology from March 2020 to March 2021.The ophthalmic parameters of each patient were recorded,and optical coherence tomography was used to evaluate the retinal thickness in the layers.RESULTS:This study enrolled a total of 85 participants,with a mean age of 40.44±11.52 years,including 61 females(72%).The control group consisted of 43 individuals with a mean age of 39.49±11.07 years,while the MS group comprised 42 participants with a mean age of 41.40±12.01 years.The mean disease duration in the MS group was 8.45±6.04 a.The thickness of the ganglion cell layer in the right eye was significantly lower in the MS group compared to the control group(P=0.034).In addition,except for the left nasal sector(P=0.106),the mean peripapillary neurofibrillation in all examined sectors were significantly lower in the MS group than in the control group(P<0.05).The average vessel density in both the deep and superficial capillary plexuses across all regions of both eyes was lower in the MS group than in the control group,with all comparisons for the superficial capillary plexus showing statistical significance(P<0.05 for all except the left nasal sector).CONCLUSION:The thickness of the retina of patients with MS is significantly reduced.Therefore,optical coherence tomography results can be used as a reliable tool to evaluate disease progression and prognosis in MS patients. 展开更多
关键词 multiple sclerosis optical coherence tomography RETINA retinal vascular disorder retinal layer thickness
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Oligodendrocyte ferroptosis:Novel mechanisms in multiple sclerosis
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作者 Valentina Saverio Dmitry Lim Marco Corazzari 《Neural Regeneration Research》 2026年第8期3561-3562,共2页
Myelination in the central nervous system(CNS)is a highly intricate process,exclusive to vertebrates,that relies on the coordinated interaction between oligodendrocytes(OLs)and neurons.In addition to their role in for... Myelination in the central nervous system(CNS)is a highly intricate process,exclusive to vertebrates,that relies on the coordinated interaction between oligodendrocytes(OLs)and neurons.In addition to their role in forming myelin,accumulating evidence indicates that OLs provide crucial trophic support to axons,contributing to normal CNS function.Notably,OL injury and loss are observed in a variety of human conditions,including stroke,traumatic injuries of the brain and spinal cord,as well as neurodegenerative disorders such as multiple sclerosis(MS). 展开更多
关键词 central nervous system central nervous system cns ferroptosis OLIGODENDROCYTE MYELINATION multiple sclerosis vertebrates trophic support
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Incorporating multiple scenarios and landscape ecological risk to optimize ecological security patterns: A Wei River Basin case study
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作者 Xueting Wu Jinghu Pan 《Chinese Journal of Population,Resources and Environment》 2026年第1期94-109,共16页
Under the influence of human activities,landscape fragmentation in the Wei River Basin(WRB)has become increasingly severe.Upstream development has intensified soil erosion,and industrial and agricultural pollution in ... Under the influence of human activities,landscape fragmentation in the Wei River Basin(WRB)has become increasingly severe.Upstream development has intensified soil erosion,and industrial and agricultural pollution in the middle reaches has degraded water quality.Rapid urbanization has further caused habitat fragmentation and biodiversity loss.Collectively,these challenges threaten human well-being and hinder sustainable development,making the construction and optimization of an ecological security pattern(ESP)urgently necessary.However,existing studies often fail to systematically integrate future landscape ecological risk(LER)assessment with ESP optimization.This study evaluated regional LER using the“ecological patches-ecological resistance surface(ERS)-ecological corridor”framework,combined with land-use predictions under three development scenarios,and optimized the ESP by adjusting the ERS and extracting ecological corridors.The results indicate that the LER in the WRB follows an“inverted N”distribution,with low-risk areas concentrated in forested mountain regions and high-risk areas mainly in cultivated land subject to intensive human activity.Across future scenarios,ESPs showed fewer ecological breakpoints and improved landscape connectivity than the 2020 baseline.Scenario-based differences emerged in the spatial configuration of ERS adjustments,with the ecological protection scenario yielding the lowest LER and most favorable ESP.This study demonstrates the deep integration of multi-scenario simulation with LER assessment,providing a new framework for ESP optimization.The findings have guiding significance for ecological protection and coordinated development in the WRB and offer a novel paradigm for sustainable development in ecologically fragile basins worldwide. 展开更多
关键词 Ecological security pattern multiple scenarios Landscape ecological risk Ecological security pattern optimization
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