When components overlap, the aircraft multiple-hit vulnerability analysis usually consists of two steps. The first is to determine the aircraft unique existent states using vulnerable area decomposition method, and th...When components overlap, the aircraft multiple-hit vulnerability analysis usually consists of two steps. The first is to determine the aircraft unique existent states using vulnerable area decomposition method, and the second is to calculate the aircraft cumulated probability of kill using Markov chain method for exact solution or Monte Carlo method for solving the combinatorial explosion problem. This article proposes a direct simulation method for calculating the aircraft multiple-hit vulnerability in order to avoid the complex vulnerable area decomposition issue. In this method, random method is adopted to produce the multiple-hit locations and Bernoulli trial is used to determine the kill or no kill of each component hit by one shot line, and kill tree is checked to determine aircraft existent states during one simulation. When the number of times of simulation is large enough, the aircraft multiple-hit vulnerability can be statistically obtained. Analysis shows that the proposed direct simulation method can provide good accuracy compared with Markov chain method and avoid the combinatorial explosion problem, and does not need the complex vulnerable area decomposition and can directly calculate the aircraft multiple-hit vulnerability. Another important finding is the binomial or Poisson simplified approach is sometimes very poor in accuracy, and should be used cautiously.展开更多
Nonalcoholic fatty liver disease(NAFLD)refers to fatty liver disease caused by liver injury factors other than alcohol.The disease is characterized by diffuse fat infiltration,including simple steatosis(no inflammator...Nonalcoholic fatty liver disease(NAFLD)refers to fatty liver disease caused by liver injury factors other than alcohol.The disease is characterized by diffuse fat infiltration,including simple steatosis(no inflammatory fat deposition),nonalcoholic fatty hepatitis,liver fibrosis,and so on,which may cause liver cirrhosis,liver failure,and even liver cancer in the later stage of disease progression.At present,the pathogenesis of NAFLD is still being studied.The"two-hit"theory,represented by lipid metabolism disorder and inflammatory reactions,is gradually enriched by the"multiple-hit"theory,which includes multiple factors,such as insulin resistance and adipocyte dysfunction.In recent years,vascular endothelial growth factor B(VEGFB)has been reported to have the potential to regulate lipid metabolism and is expected to become a novel target for ameliorating metabolic diseases,such as obesity and type 2 diabetes.This review summarizes the regulatory role of VEGFB in the onset and development of NAFLD and illustrates its underlying molecular mechanism.In conclusion,the signaling pathway mediated by VEGFB in the liver may provide an innovative approach to the diagnosis and treatment of NAFLD.展开更多
基金Ph.D. Programs Foundation of Ministry of Education of China （200806991002） Natural Science Foundation of Shaanxi Province （SJ08A11）+2 种基金 NPU Foundation for Fundamental Research （NPU- FFR-JC200804） Young Teacher Foundation of NPU （W016208） ＂Aoxiang Star Project＂ of NPU.
文摘When components overlap, the aircraft multiple-hit vulnerability analysis usually consists of two steps. The first is to determine the aircraft unique existent states using vulnerable area decomposition method, and the second is to calculate the aircraft cumulated probability of kill using Markov chain method for exact solution or Monte Carlo method for solving the combinatorial explosion problem. This article proposes a direct simulation method for calculating the aircraft multiple-hit vulnerability in order to avoid the complex vulnerable area decomposition issue. In this method, random method is adopted to produce the multiple-hit locations and Bernoulli trial is used to determine the kill or no kill of each component hit by one shot line, and kill tree is checked to determine aircraft existent states during one simulation. When the number of times of simulation is large enough, the aircraft multiple-hit vulnerability can be statistically obtained. Analysis shows that the proposed direct simulation method can provide good accuracy compared with Markov chain method and avoid the combinatorial explosion problem, and does not need the complex vulnerable area decomposition and can directly calculate the aircraft multiple-hit vulnerability. Another important finding is the binomial or Poisson simplified approach is sometimes very poor in accuracy, and should be used cautiously.
文摘Nonalcoholic fatty liver disease(NAFLD)refers to fatty liver disease caused by liver injury factors other than alcohol.The disease is characterized by diffuse fat infiltration,including simple steatosis(no inflammatory fat deposition),nonalcoholic fatty hepatitis,liver fibrosis,and so on,which may cause liver cirrhosis,liver failure,and even liver cancer in the later stage of disease progression.At present,the pathogenesis of NAFLD is still being studied.The"two-hit"theory,represented by lipid metabolism disorder and inflammatory reactions,is gradually enriched by the"multiple-hit"theory,which includes multiple factors,such as insulin resistance and adipocyte dysfunction.In recent years,vascular endothelial growth factor B(VEGFB)has been reported to have the potential to regulate lipid metabolism and is expected to become a novel target for ameliorating metabolic diseases,such as obesity and type 2 diabetes.This review summarizes the regulatory role of VEGFB in the onset and development of NAFLD and illustrates its underlying molecular mechanism.In conclusion,the signaling pathway mediated by VEGFB in the liver may provide an innovative approach to the diagnosis and treatment of NAFLD.
