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Prognostic value of peripheral eosinophil counts in patients with newly diagnosed multiple myeloma
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作者 Xu Chen Xiaoyan Yue +10 位作者 Hao Jiang Qianqian Yang Jinwen Huang Wenjue Pan Xiujie Zhao Xiufeng Yin Panpan Wang Liangning Hu Xiaoli Guo Fangfei Shao Haowen Xiao 《Cancer Biology & Medicine》 2025年第5期481-487,共7页
Precise risk stratification is crucial for selecting the optimal risk-adapted treatment for newly diagnosed multiple myeloma (NDMM) patients. Various prognostic factors and staging systems have been developed to predi... Precise risk stratification is crucial for selecting the optimal risk-adapted treatment for newly diagnosed multiple myeloma (NDMM) patients. Various prognostic factors and staging systems have been developed to predict NDMM patient outcomes. The Durie-Salmon (D-S) staging system reflects tumor burden and clinical progression staging with prognostic value. 展开更多
关键词 clinical progression peripheral eosinophil counts multiple myeloma prognostic value prognostic factors staging systems precise risk stratification risk stratification staging system
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FAULT DETECTION FOR MULTIPLE-VALUED LOGIC CIRCUITS WITH FANOUT-FREE 被引量:1
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作者 PanZhongliang 《Journal of Electronics(China)》 2004年第5期376-383,共8页
The single fault and multiple fault detections for multiple-valued logic circuits are studied in this paper. Firstly, it is shown that the cardinality of optimal single fault test set for fanout-free m-valued circuits... The single fault and multiple fault detections for multiple-valued logic circuits are studied in this paper. Firstly, it is shown that the cardinality of optimal single fault test set for fanout-free m-valued circuits with n primary inputs is not more than n + 1, for linear tree circuits is two, and for multiplication modulo circuits is two if n is an odd number or if n is an even number and m > 3, where the optimal test set of a circuit has minimal number of test vectors. Secondly,it is indicated that the cardinality of optimal multiple fault test set for linear tree circuits with n primary inputs is 1 + [n/(m - 1)], for multiplication modulo circuits is n+ 1, for fanout-free circuits that consist of 2-input linear tree circuits and 2-input multiplication modulo circuits is not greater than n+ 1, where [x] denotes the smallest integer greater than or equal to x. Finally,the single fault location approaches of linear tree circuits and multiplication modulo circuits are presented, and all faults in the two types of circuits can be located by using a test set with n + 1 vectors. 展开更多
关键词 multiple-valued logic Digital circuits Fault detection Single fault multiple faults
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SPECTRAL ANALYSIS OF SOME INDEPENDENCES OF MULTIPLE-VALUED LOGICAL FUNCTIONS ON THEIR VARIABLES
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作者 武传坤 《Journal of Electronics(China)》 1993年第3期217-226,共10页
There are many kinds of special relationships between multiple-valued logical func-tions and their variables, and they are difficult to be judged from their expressions. In thispaper, some sufficient and necessary con... There are many kinds of special relationships between multiple-valued logical func-tions and their variables, and they are difficult to be judged from their expressions. In thispaper, some sufficient and necessary conditions of the independence and statistical independenceof multiple-valued logical functions on their variables are given. Some conditions of algebraicindependence of multiple-valued logical functions on some of their variables and the way to de-generate a function to the greatest extent are proposed, and some applications of these resultsare indicated. All the results are studied by using Chrestenson spectral techniques. 展开更多
关键词 multiple-valued logical function Chrestenson SPECTRUM DEGENERATION Correlationimmunity Linear code
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Phase I clinical study of humanized BCMA-single-domain antibodies targeting CAR-T in patients with relapsed or refractory multiple myeloma
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作者 Gaofeng Zheng Ruyi Xu +6 位作者 Heng Mei Xiaoyan Han Donghua He Yanling Weng Cheng Wen Zhuoxiao Cao Zhen Cai 《Cancer Biology & Medicine》 2025年第11期1377-1380,共4页
Multiple myeloma(MM),one of the most common hemato logical neoplasms worldwide,originates from malignant plasma cells in the bone marrow.MM remains an incurable disease,although continued treatment advancements have m... Multiple myeloma(MM),one of the most common hemato logical neoplasms worldwide,originates from malignant plasma cells in the bone marrow.MM remains an incurable disease,although continued treatment advancements have markedly increased overall survival.Many patients with MM eventually experience relapse or become treatment-refractory1.Patients with relapsed or refractory multiple myeloma(RRMM)become progressively more challenging to manage and have poor prognosis2. 展开更多
关键词 CAR T relapsed refractory multiple myeloma bone marrowmm phase I clinical study hemato logical neoplasms multiple myeloma rrmm become malignant plasma cells multiple myeloma mm one
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Spatial heterogeneity of groundwater depths in coastal cities and their responses to multiple factors interactions by interpretable machine learning models
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作者 Yuming Mo Jing Xu +5 位作者 Senlin Zhu Beibei Xu Jinran Wu Guangqiu Jin You-Gan Wang Ling Li 《Geoscience Frontiers》 2025年第3期223-241,共19页
Understanding spatial heterogeneity in groundwater responses to multiple factors is critical for water resource management in coastal cities.Daily groundwater depth(GWD)data from 43 wells(2018-2022)were collected in t... Understanding spatial heterogeneity in groundwater responses to multiple factors is critical for water resource management in coastal cities.Daily groundwater depth(GWD)data from 43 wells(2018-2022)were collected in three coastal cities in Jiangsu Province,China.Seasonal and Trend decomposition using Loess(STL)together with wavelet analysis and empirical mode decomposition were applied to identify tide-influenced wells while remaining wells were grouped by hierarchical clustering analysis(HCA).Machine learning models were developed to predict GWD,then their response to natural conditions and human activities was assessed by the Shapley Additive exPlanations(SHAP)method.Results showed that eXtreme Gradient Boosting(XGB)was superior to other models in terms of prediction performance and computational efficiency(R^(2)>0.95).GWD in Yancheng and southern Lianyungang were greater than those in Nantong,exhibiting larger fluctuations.Groundwater within 5 km of the coastline was affected by tides,with more pronounced effects in agricultural areas compared to urban areas.Shallow groundwater(3-7 m depth)responded immediately(0-1 day)to rainfall,primarily influenced by farmland and topography(slope and distance from rivers).Rainfall recharge to groundwater peaked at 50%farmland coverage,but this effect was suppressed by high temperatures(>30℃)which intensified as distance from rivers increased,especially in forest and grassland.Deep groundwater(>10 m)showed delayed responses to rainfall(1-4 days)and temperature(10-15 days),with GDP as the primary influence,followed by agricultural irrigation and population density.Farmland helped to maintain stable GWD in low population density regions,while excessive farmland coverage(>90%)led to overexploitation.In the early stages of GDP development,increased industrial and agricultural water demand led to GWD decline,but as GDP levels significantly improved,groundwater consumption pressure gradually eased.This methodological framework is applicable not only to coastal cities in China but also could be extended to coastal regions worldwide. 展开更多
关键词 Groundwater depth Spatial heterogeneity multiple influence factorsCoastal cities Machine Learning models SHAP values
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Enterprise Value Valuation-BYD as an Example Based on SWOT Model and Multiple Regression Model
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作者 YANG Siqi 《Management Studies》 2024年第4期197-217,共21页
BYD is one of the largest new energy vehicle companies in China.Analyzing its scenario and the factors that affect its value helps to understand and identify development opportunities and potential problems.On one han... BYD is one of the largest new energy vehicle companies in China.Analyzing its scenario and the factors that affect its value helps to understand and identify development opportunities and potential problems.On one hand,this paper makes a qualitative analysis of BYD,using SWOT model to study the internal capability and external environment of BYD.On the other hand,the multiple regression model is used for quantitative analysis of BYD’s enterprise value,and the model is established based on three factors:enterprise fundamentals,investor behavior and psychology,and macroeconomic policy uncertainty,and the stepwise regression is carried out.The results show that the increase of institutional investors’shareholding ratio,the increase of investor sentiment index,and the increase of M2 growth rate will increase the overall enterprise value,while the increase of economic policy uncertainty will decrease the enterprise value. 展开更多
关键词 BYD enterprise value multiple regression analysis investor behavior and psychology macroeconomic policy uncertainty
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ON MULTIPLE WIENER INTEGRAL EXPANSIONS FOR D'-VALUED NONLINEAR RANDOM FUNCTIONALS
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作者 Wu Jianglun 《Acta Mathematica Scientia》 SCIE CSCD 1993年第2期220-228,共9页
In this paper,the multiple stochastic integral with respect to a Wiener D'-process is defined.And also it is shown that for a D'-valued nonlinear random functional there exists a sequence of multiple integral ... In this paper,the multiple stochastic integral with respect to a Wiener D'-process is defined.And also it is shown that for a D'-valued nonlinear random functional there exists a sequence of multiple integral kernels such that the nonlinear functional can be expanded by series of multiple Wiener integrals of the integral kernels with respect to the Wiener D'-process. 展开更多
关键词 valued NONLINEAR RANDOM FUNCTIONALS ON multiple WIENER INTEGRAL EXPANSIONS FOR D ONB
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The Biorthogonality of Multiple Vector-valued Bivariate Wavelet Packets
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作者 CHEN Shao-dong HUANG Na 《Chinese Quarterly Journal of Mathematics》 CSCD 2010年第2期208-213,共6页
The notion of a sort of biorthogonal multiple vector-valued bivariate wavelet packets,which are associated with a quantity dilation matrix,is introduced.The biorthogonality property of the multiple vector-valued wavel... The notion of a sort of biorthogonal multiple vector-valued bivariate wavelet packets,which are associated with a quantity dilation matrix,is introduced.The biorthogonality property of the multiple vector-valued wavelet packets in higher dimensions is studied by means of Fourier transform and integral transform biorthogonality formulas concerning these wavelet packets are obtained. 展开更多
关键词 BIVARIATE multiple vector-valued multiresolution analysis multiple vectorvalued scaling function multiple vector-valued wavelet packets biorthogonality
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Multiplier Design Utilizing Tri Valued Logic for RLNS Based DSP Applications
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作者 Shalini Radakirishnan Valliammal Sampath Palaniswami 《Circuits and Systems》 2016年第4期417-433,共17页
Residue Number System (RNS) has proved shaping the Digital Signal Processing (DSP) units into highly parallel, faster and secured entities. The computational complexity of the multiplication process for a RNS based de... Residue Number System (RNS) has proved shaping the Digital Signal Processing (DSP) units into highly parallel, faster and secured entities. The computational complexity of the multiplication process for a RNS based design can be reduced by indulging Logarithmic Number System (LNS). The combination of these unusual number systems forms Residue Logarithmic Number System (RLNS) that provides simple internal architectures. Till date RLNS based processing units are designed for binary logic based circuits. In order to reduce the number of input output signals in a system, the concept of Multiple Valued Logic (MVL) is introduced in literature. In that course of research, this paper uses Tri Valued Logic (TVL) in RLNS technique proposed, to further reduce the chip area and delay value. Thus in this research work three different concepts are proposed, it includes the design of multiplier for RLNS based application for number of bits 8, 16 and 32. Next is the utilization of TVL in the proposed multiplication structure for RLNS based system along with the error correction circuits for the ternary logarithmic and antilogarithmic conversion process. Finally the comparison of the two multiplication schemes with the existing research of multiplier design for RNS based system using booth encoding concepts. It can be found that the proposed technique using TVL saves on an average of about 63% of area occupied and 97% of delay value respectively than the existing technique. 展开更多
关键词 Residue Number System (RNS) Residue Logarithmic Number System (RLNS) Tri valued logic (TVL) Binary logic Error Correction Circuits
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Multiple positive solutions for a class of nonlinear four-point boundary value problem with p-Laplacian 被引量:10
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作者 LI Xiang-feng 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2008年第2期143-150,共8页
This paper deals with the existence of multiple positive solutions for a class of nonlinear singular four-point boundary value problem with p-Laplacian:{(φ(u′))′+a(t)f(u(t))=0, 0〈t〈1, αφ(u(... This paper deals with the existence of multiple positive solutions for a class of nonlinear singular four-point boundary value problem with p-Laplacian:{(φ(u′))′+a(t)f(u(t))=0, 0〈t〈1, αφ(u(0))-βφ(u′(ξ))=0,γφ(u(1))+δφ(u′(η))0,where φ(x) = |x|^p-2x,p 〉 1, a(t) may be singular at t = 0 and/or t = 1. By applying Leggett-Williams fixed point theorem and Schauder fixed point theorem, the sufficient conditions for the existence of multiple (at least three) positive solutions to the above four-point boundary value problem are provided. An example to illustrate the importance of the results obtained is also given. 展开更多
关键词 p-Laplacian operator multiple positive solution four-point singular boundary value problem fixed-point theorem.
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Multiple Positive Solutions of Boundary Value Problems for Systems of Nonlinear Third-Order Differential Equations 被引量:2
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作者 Yaohong LI Xiaoyan ZHANG 《Journal of Mathematical Research with Applications》 CSCD 2013年第3期321-329,共9页
In this paper, we consider boundary value problems for systems of nonlinear third- order differential equations. By applying the fixed point theorems of cone expansion and compression of norm type and Leggett-Williams... In this paper, we consider boundary value problems for systems of nonlinear third- order differential equations. By applying the fixed point theorems of cone expansion and compression of norm type and Leggett-Williams fixed point theorem, the existence of multiple positive solutions is obtained. As application, we give some examples to demonstrate our results. 展开更多
关键词 boundary value problem multiple positive solutions fixed-point theorem.
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Existence of Multiple Positive Solutions for Fourth Order Two-point Boundary Value Problems 被引量:1
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作者 戚仕硕 《Northeastern Mathematical Journal》 CSCD 2002年第1期63-72,共10页
The present paper tackles two-point boundary value problems for fourth-order differential equations as follows:Several existence theorems on multiple positive solutions to the problems are obtained, and some examples ... The present paper tackles two-point boundary value problems for fourth-order differential equations as follows:Several existence theorems on multiple positive solutions to the problems are obtained, and some examples are given to show the validity of these results. 展开更多
关键词 existence theorem multiple positive solution fourth-order boundary value problem
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Efficient Load Balancing with MANET Propagation of Least Common Multiple Routing and Fuzzy Logic 被引量:1
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作者 V.Gayatri M.Senthil Kumaran 《Computers, Materials & Continua》 SCIE EI 2022年第7期1831-1845,共15页
Mobile Ad Hoc Network(MANET)is a group of node that would interrelate among each other through onemulti-hop wireless link,wherein the nodes were able to move in response to sudden modifications.The objective of MANET ... Mobile Ad Hoc Network(MANET)is a group of node that would interrelate among each other through onemulti-hop wireless link,wherein the nodes were able to move in response to sudden modifications.The objective of MANET routing protocol is to quantify the route and compute the best path,but there exists a major decrease in energy efficiency,difficulty in hop selection,cost estimation,and efficient load-balancing.In this paper,a novel least common multipath-based routing has been proposed.Multipath routing is used to find a multipath route from source and destination.Load balancing is of primary importance in the mobile ad-hoc networks,due to limited bandwidth among the nodes and the initiator of the load routing discovery phase in the multipath routing protocol.Fuzzy logic for load balancing multipath routing in MANETs is proposed,which ensures the data packets are sent through a path with the variance of binary sets to predict the original transformation of the data to be received in the system.The main objective of the proposed system is to reduce the routing time of data packets and avoid the traffic based on multipath source and destination.The experimental results have to verify 96.7%efficiency in balancing the load. 展开更多
关键词 MANETS multipath routing least common multiple routing(LCMR)and fuzzy logic route requests(RREQs) route replies(RREPs)
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Ideal Resolution Principle for Lattice-Valued First-Order Logic Based on Lattice Implication Algebra 被引量:1
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作者 许伟涛 徐扬 《Journal of Shanghai Jiaotong university(Science)》 EI 2012年第2期178-181,共4页
As a continuate work,ideal-based resolution principle for lattice-valued first-order logic system LF(X) is proposed,which is an extension of α-resolution principle in lattice-valued logic system based on lattice impl... As a continuate work,ideal-based resolution principle for lattice-valued first-order logic system LF(X) is proposed,which is an extension of α-resolution principle in lattice-valued logic system based on lattice implication algebra.In this principle,the resolution level is an ideal of lattice implication algebra,instead of an element in truth-value field.Moreover,the soundness theorem is given.In the light of lifting lemma,the completeness theorem is established.This can provide a new tool for automated reasoning. 展开更多
关键词 automated reasoning lattice-valued logic lattice implication algebra generalized clause
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The Theory of Membership Degree of Γ-Conclusion in Several n-Valued Logic Systems 被引量:2
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作者 Jiancheng Zhang 《American Journal of Operations Research》 2012年第2期147-152,共6页
Based on the analysis of the properties of Γ-conclusion by means of deduction theorems, completeness theorems and the theory of truth degree of formulas, the present papers introduces the concept of the membership de... Based on the analysis of the properties of Γ-conclusion by means of deduction theorems, completeness theorems and the theory of truth degree of formulas, the present papers introduces the concept of the membership degree of formulas A is a consequence of Γ (or Γ-conclusion) in Lukasiewicz n-valued propositional logic systems, Godel n-valued propositional logic system and the R0 n-valued propositional logic systems. The condition and related calculations of formulas A being Γ-conclusion were discussed by extent method. At the same time, some properties of membership degree of formulas A is a Γ-conclusion were given. We provide its algorithm of the membership degree of formulas A is a Γ-conclusion by the constructions of theory root. 展开更多
关键词 N-valued Propositional logic Γ-Conclusion Theory ROOT MEMBERSHIP Degree
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The Uniqueness of Meromorphic Functions Sharing Small Functions Dealing with Multiple Values
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作者 Yang TAN Yinying KONG 《Journal of Mathematical Research with Applications》 CSCD 2020年第6期609-616,共8页
In this paper,we investigate two meromorphic functions which share small functions dealing with multiple values.By constructing auxiliary functions,especially by the deep analysis of counting functions we obtain some ... In this paper,we investigate two meromorphic functions which share small functions dealing with multiple values.By constructing auxiliary functions,especially by the deep analysis of counting functions we obtain some results which extend the existing results of some scholars. 展开更多
关键词 meromorphic function small function UNIQUENESS multiple value
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Research on Fuzzy Multiple Attribute Route Evaluation Decision Method
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作者 Geng Yu Qing Liu 《World Journal of Engineering and Technology》 2019年第2期65-72,共8页
The route evaluation is an important basis for airlines to make route decisions. In order to solve the fuzzy multiple attribute route decision problem, route attribute weight was completely unknown, and the route eval... The route evaluation is an important basis for airlines to make route decisions. In order to solve the fuzzy multiple attribute route decision problem, route attribute weight was completely unknown, and the route evaluation fuzzy language information was given, the fuzzy language and preference information were converted into trapezoidal fuzzy numbers. A programming model was constructed by minimizing the total deviation between trapezoidal fuzzy numbers to determining the weight of each attribute in the route decision, By weighting the average of the route attribute value and the weights value, compared the expected value of fuzzy comprehensive evaluation for each route, and ranking alternatives by using the expected value operator of fuzzy variable. Finally, a numerical example was used to illustrate the proposed method. The results show that the method can be used by air-lines to solve multiple attribute route decision problems with unknown weights, and the method is scientific and effective. 展开更多
关键词 ROUTE DECISION FUZZY Language multiple ATTRIBUTE DECISION MAKING Trapezoidal FUZZY Number EXPECTED value
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Lewisian Connexive Logics
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作者 Chen Huang Xuefeng Wen 《逻辑学研究》 2025年第3期96-114,共19页
In connexive logic,two fundamental ideas are observed:first,no proposition im-plies or is implied by its own negation;second,if a proposition implies p then it will not imply the negation of 4p.In classical logic,neit... In connexive logic,two fundamental ideas are observed:first,no proposition im-plies or is implied by its own negation;second,if a proposition implies p then it will not imply the negation of 4p.In classical logic,neither of the ideas holds,which makes it difficult to give a natural semantics for connexive logic.By combining Kleene's three valued logic and Lewis'conditional logic,we propose a new natural semantics for connexive logic.We give four ax-iomatic systems characterizing different classes of selection models in the new semantics.We prove soundness and completeness of these logics and compare them with some comexive 1og-ics in the literature. 展开更多
关键词 natural semantics Lewisian Kleenes Three valued combining kleenes three valued logic Connexive logic lewisconditional logicwe
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MULTIPLE POSITIVE SOLUTIONS OF A SINGULAR (n-1,1) CONJUGATE BOUNDARY VALUE PROBLEM WITH DELAY 被引量:2
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作者 Weng Peixuan\ Tian YanlingDept. of Math.,South China Normal Univ.,Guangzhou 51 0 631 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2000年第2期128-136,共9页
This paper discusses the singular ( n\|1,1 ) conjugate boundary value problem as follows by using a fixed point index theorem in cones[HL(2:1,Z;2,Z]u (n) (t)+a(t)f(u(w(t)))=0,(0<t<1), u(t)=φ(t),(-τ≤t&l... This paper discusses the singular ( n\|1,1 ) conjugate boundary value problem as follows by using a fixed point index theorem in cones[HL(2:1,Z;2,Z]u (n) (t)+a(t)f(u(w(t)))=0,(0<t<1), u(t)=φ(t),(-τ≤t<0), u (j) (0)=u(1)=0,(1≤j≤n-2).Effort is devoted to give some sufficient conditions for which the equation has at least two positive solutions.An example to illustrate the application of this theorem is given. [FQ(6*2。39,X-W] 展开更多
关键词 Conjugate boundary value problem functional differential equation multiple positive solution.Keywords:Conjugateboundaryvalueproblem functionaldifferentialequation multiplepositivesolu-tion.
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Estimating the expected value of multiple prospects in bidding blocks
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作者 Jun Li Xuebin Huang 《Energy Geoscience》 2022年第3期263-269,共7页
In recent years,China has accelerated the reform of its oil and gas management system,especially in competitive transfer of mining rights.Evaluating the expected value(EV)of lease blocks is crucial for the bidding dec... In recent years,China has accelerated the reform of its oil and gas management system,especially in competitive transfer of mining rights.Evaluating the expected value(EV)of lease blocks is crucial for the bidding decision of oil companies.When bidding for a block with several individual prospects,the simple addition of each prospect EV usually leads to overly high and optimistic resource volume and value estimates.For the assessment of the EV of a multi-prospect block,two factors should be considered.Firstly,the geological setting of the prospects,including their relative spatial relationship,their chance of geological success,their resources and their geological dependency,etc.The second factor is the exploration strategy of oil companies,concerned with the dry hole tolerance,the committed wells and the drilling priorities for the prospects,etc.A probabilistic method to assess the EV of a multi-prospect block is proposed,which proves to be favorable for formulating a bidding strategy for oil companies.In addition,a case study on two specific blocks with several prospects is presented to illustrate the effect of the above mentioned factors on the EV. 展开更多
关键词 Expected value(EV) multiple prospects Bidding block Probabilistic method
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