During the development blasting of circular tunnels, the detonation of multiple blastholes arranged onconcentric circles induces a complex dynamic response in the surrounding rocks. This process involvesmultiple blast...During the development blasting of circular tunnels, the detonation of multiple blastholes arranged onconcentric circles induces a complex dynamic response in the surrounding rocks. This process involvesmultiple blast loadings, static stress unloadings, and stress redistributions. In this study, the dynamicstresses of the surrounding rocks during development blasting, considering multiple blasting-unloadingstages with exponential paths and triangular paths (linear simplified paths of exponential paths), aresolved based on the dynamic theory and the Fourier transform method. Then, a corresponding discreteelement model is established using particle flow code (PFC). The multiple-stage dynamic stress andfracture distribution under different in situ stress levels and lateral coefficients are investigated. Theoreticalresults indicate that the peak compressive stresses in the surrounding rocks induced by bothtriangular and exponential paths are equal, while the triangular path generates greater additional dynamictensile stresses, particularly in the circumferential direction, compared to the exponential path.Numerical results show that the exponential path causes less dynamic circumferential tensile damageand forms fewer radial fractures than the triangular path in the first few blast stages;conversely, itexacerbates the damage and instability in the final blasting-unloading stage and forms more circumferentialfractures. Furthermore, the in situ stress determines which of the two opposite effects isdominant. Therefore, when using overly simplified triangular paths to evaluate the stability of surroundingrocks, potential overestimation or underestimation caused by different failure mechanismsshould be considered. Specifically, under high horizontal and vertical stresses, the static stress redistributionwith layer-by-layer blasting suppresses dynamic circumferential tensile and radial compressivedamage. The damage evolution of surrounding rocks in multi-stage blasting under different in situstresses is summarized and classified according to the damage mechanism and characteristics, which canguide blasting and support design.展开更多
Understanding spatial heterogeneity in groundwater responses to multiple factors is critical for water resource management in coastal cities.Daily groundwater depth(GWD)data from 43 wells(2018-2022)were collected in t...Understanding spatial heterogeneity in groundwater responses to multiple factors is critical for water resource management in coastal cities.Daily groundwater depth(GWD)data from 43 wells(2018-2022)were collected in three coastal cities in Jiangsu Province,China.Seasonal and Trend decomposition using Loess(STL)together with wavelet analysis and empirical mode decomposition were applied to identify tide-influenced wells while remaining wells were grouped by hierarchical clustering analysis(HCA).Machine learning models were developed to predict GWD,then their response to natural conditions and human activities was assessed by the Shapley Additive exPlanations(SHAP)method.Results showed that eXtreme Gradient Boosting(XGB)was superior to other models in terms of prediction performance and computational efficiency(R^(2)>0.95).GWD in Yancheng and southern Lianyungang were greater than those in Nantong,exhibiting larger fluctuations.Groundwater within 5 km of the coastline was affected by tides,with more pronounced effects in agricultural areas compared to urban areas.Shallow groundwater(3-7 m depth)responded immediately(0-1 day)to rainfall,primarily influenced by farmland and topography(slope and distance from rivers).Rainfall recharge to groundwater peaked at 50%farmland coverage,but this effect was suppressed by high temperatures(>30℃)which intensified as distance from rivers increased,especially in forest and grassland.Deep groundwater(>10 m)showed delayed responses to rainfall(1-4 days)and temperature(10-15 days),with GDP as the primary influence,followed by agricultural irrigation and population density.Farmland helped to maintain stable GWD in low population density regions,while excessive farmland coverage(>90%)led to overexploitation.In the early stages of GDP development,increased industrial and agricultural water demand led to GWD decline,but as GDP levels significantly improved,groundwater consumption pressure gradually eased.This methodological framework is applicable not only to coastal cities in China but also could be extended to coastal regions worldwide.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning ofte...BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.展开更多
A multiple round quantum dense coding scheme based on the quantum phase estimation algorithm is proposed and implemented in a three qubit nuclear magnetic resonance (NMR) quantum computer. Using an m + 1 qubit system,...A multiple round quantum dense coding scheme based on the quantum phase estimation algorithm is proposed and implemented in a three qubit nuclear magnetic resonance (NMR) quantum computer. Using an m + 1 qubit system, Bob can transmit one of 2m+1 messages to Alice, through manipulating only one qubit and exchanging it between Alice and Bob for m rounds. The information capacity is enhanced to m + 1 bits as compared to m bits in a classical scheme. The scheme has been demonstrated in NMR system, and the experimental results show a good agreement between theory and experiment.展开更多
The development of a multiple level underground mine is a complex task in which geology,engineering,ground control,and unit operations are integrated into a single mine design.The components are interdependent and mus...The development of a multiple level underground mine is a complex task in which geology,engineering,ground control,and unit operations are integrated into a single mine design.The components are interdependent and must function cohesively to ensure a profitable underground mining operation.To optimize reserve recovery,mine planning should begin from the lowest level and progress up.This limits any misjudgments or oversights of a given level affecting the underlying levels and ensures the ability to maximize recovery from each level.Mine planning should start with the exploration and characterization of the geologic setting.Once the reserve geology and quality is well understood,then mine planning can begin with respect to the following:(1)orientation of mine works with respect to horizontal stress;(2)access to the reserve;(3)determination of opening widths;(4)selection of back,floor horizons and pillar centers;(5)selection of development and secondary mining heights;(6)appropriate inter-burden thicknesses;and(7)examining the stability of the multiple level mine through numerical modeling.The multiple level mine design process and decisions are presented through a case history example.The theme is that there is one opportunity to"get it right"and many chances to overlook a small aspect within the design that will plague the mine throughout all levels and through the entirety of its operating life.展开更多
Fluid resonance within narrow gaps in multiple-box systems with sharp and round inlet configurations are investigated by using the potential flow and viscous fluid flow models in the OpenFOAM^(■)package.Evident discr...Fluid resonance within narrow gaps in multiple-box systems with sharp and round inlet configurations are investigated by using the potential flow and viscous fluid flow models in the OpenFOAM^(■)package.Evident discrepancy between two numerical models can be observed for sharp inlet configurations.In addition to the dramatical decrease of resonant amplitude in narrow gaps,some peak values at the higher resonant frequencies predicted by the potential flow model even disappear in the viscous fluid flow results.The decreased normalized resonant amplitudes with the increase of incident wave amplitude can be observed for sharp inlet configurations.However,the hydrodynamic behaviors of multiple-box system with round inlet configurations between potential flow and viscous fluid flow models are quite similar with each other.The normalized resonant amplitudes are nearly independent of incident wave amplitudes for multiple-box systems with round inlet configurations.This implies that the energy dissipation associated with fluid viscosity and flow rotation plays an important role in the gap resonance for sharp inlet configurations;while it is insignificant for round inlet configurations.展开更多
The core of smoothed particle hydrodynamics （SPH） is the nearest neighbor search subroutine. In this paper, a nearest neighbor search algorithm which is based on multiple background grids and support variable smooth...The core of smoothed particle hydrodynamics （SPH） is the nearest neighbor search subroutine. In this paper, a nearest neighbor search algorithm which is based on multiple background grids and support variable smooth length is introduced. Through tested on lid driven cavity flow, it is clear that this method can provide high accuracy. Analysis and experiments have been made on its parallelism, and the results show that this method has better parallelism and with adding processors its accuracy become higher, thus it achieves that efficiency grows in pace with accuracy.展开更多
During underground coal gasification （UCG）, whereby coal is converted to syngas in situ, a cavity is formed in the coal seam. The cavity growth rate （CGR） or the moving rate of the gasification face is affected by...During underground coal gasification （UCG）, whereby coal is converted to syngas in situ, a cavity is formed in the coal seam. The cavity growth rate （CGR） or the moving rate of the gasification face is affected by controllable （operation pressure, gasification time, geometry of UCG panel） and uncontrollable （coal seam properties） factors. The CGR is usually predicted by mathematical models and laboratory experiments, which are time consuming, cumbersome and expensive. In this paper, a new simple model for CGR is developed using non-linear regression analysis, based on data from 1 l UCG field trials. The empirical model compares satisfactorily with Perkins model and can reliably predict CGR.展开更多
There are various analytical, empirical and numerical methods to calculate groundwater inflow into tun- nels excavated in rocky media. Analytical methods have been widely applied in prediction of groundwa- ter inflow ...There are various analytical, empirical and numerical methods to calculate groundwater inflow into tun- nels excavated in rocky media. Analytical methods have been widely applied in prediction of groundwa- ter inflow to tunnels due to their simplicity and practical base theory. Investigations show that the real amount of water infiltrating into jointed tunnels is much less than calculated amount using analytical methods and obtained results are very dependent on tunnel＇s geometry and environmental situations. In this study, using multiple regression analysis, a new empirical model for estimation of groundwater seepage into circular tunnels was introduced. Our data was acquired from field surveys and laboratory analysis of core samples. New regression variables were defined after perusing single and two variables relationship between groundwater seepage and other variables. Finally, an appropriate model for estima- tion of leakage was obtained using the stepwise algorithm. Statistics like R, R2, R2e and the histogram of residual values in the model represent a good reputation and fitness for this model to estimate the groundwater seepage into tunnels. The new experimental model was used for the test data and results were satisfactory. Therefore, multiple regression analysis is an effective and efficient way to estimate the groundwater seeoage into tunnels.展开更多
An explicit model management framework is introduced for predictive Groundwater Levels(GWL),particularly suitable to Observation Wells(OWs)with sparse and possibly heterogeneous data.The framework implements Multiple ...An explicit model management framework is introduced for predictive Groundwater Levels(GWL),particularly suitable to Observation Wells(OWs)with sparse and possibly heterogeneous data.The framework implements Multiple Models(MM)under the architecture of organising them at levels,as follows:(i)Level 0:treat heterogeneity in the data,e.g.Self-Organised Mapping(SOM)to classify the OWs;and decide on model structure,e.g.formulate a grey box model to predict GWLs.(ii)Level 1:construct MMs,e.g.two Fuzzy Logic(FL)and one Neurofuzzy(NF)models.(iii)Level 2:formulate strategies to combine the MM at Level 1,for which the paper uses Artificial Neural Networks(Strategy 1)and simple averaging(Strategy 2).Whilst the above model management strategy is novel,a critical view is presented,according to which modelling practices are:Inclusive Multiple Modelling(IMM)practices contrasted with existing practices,branded by the paper as Exclusionary Multiple Modelling(EMM).Scientific thinking over IMMs is captured as a framework with four dimensions:Model Reuse(MR),Hierarchical Recursion(HR),Elastic Learning Environment(ELE)and Goal Orientation(GO)and these together make the acronym of RHEO.Therefore,IMM-RHEO is piloted in the aquifer of Tabriz Plain with sparse and possibly heterogeneous data.The results provide some evidence that(i)IMM at two levels improves on the accuracy of individual models;and(ii)model combinations in IMM practices bring‘model-learning’into fashion for learning with the goal to explain baseline conditions and impacts of subsequent management changes.展开更多
The calculations of unsteady flow to a multiple well system with the application of boundary elementmethod (BEM) are discussed. The mathematical model of unsteady well flow is a boundary value problem ofparabolic diff...The calculations of unsteady flow to a multiple well system with the application of boundary elementmethod (BEM) are discussed. The mathematical model of unsteady well flow is a boundary value problem ofparabolic differential equation. It is changed into an elliptic one by Laplace transform to eliminate time varia-ble. The image function of water head H can be solved by BEM. We derived the boundary integral equation ofthe transformed variable H and the discretization form of it, so that there is no need to discretize the bounda-ries of well walls and it becomes easier to solve the groundwater head H by numerical inversion.展开更多
Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple rol...Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.展开更多
A credible method of calculating the detection threshold is presented for the multiple target situations, which appear frequently in the lower Doppler velocity region during the surveillance of sea with HF ground wave...A credible method of calculating the detection threshold is presented for the multiple target situations, which appear frequently in the lower Doppler velocity region during the surveillance of sea with HF ground wave radar. This method defines a whole-peak-outlier elimination （WPOE） criterion, which is based on in-peak-samples correlation of each target echo spectra, to trim off the target signals and abnormal disturbances with great amplitude from the complex spectra. Therefore, cleaned background noise samples are obtained to improve the accuracy and reliability of noise level estimation. When the background noise is nonhomogeneous, the detection samples are limited and often occupied heavily with outliers. In this case, the problem that the detection threshold is overvalued can be solved. In applications on experimental data, it is verified that this method can reduce the miss alarm rate of signal detection effectively in multiple target situations as well as make the adaptability of the detector better.展开更多
In this paper,the investigation of a novel compact 2×2,2×1,and 1×1 Ultra-Wide Band(UWB)based Multiple-Input Multiple-Output(MIMO)antenna with Defected Ground Structure(DGS)is employed.The proposed Elect...In this paper,the investigation of a novel compact 2×2,2×1,and 1×1 Ultra-Wide Band(UWB)based Multiple-Input Multiple-Output(MIMO)antenna with Defected Ground Structure(DGS)is employed.The proposed Electromagnetic Radiation Structures(ERS)is composed of multiple radiating elements.These MIMO antennas are designed and analyzed with and without DGS.The feeding is introduced by a microstrip-fed line to significantly moderate the radiating structure’s overall size,which is 60×40×1 mm.The high directivity and divergence characteristics are attained by introducing the microstripfed lines perpendicular to each other.And the projected MIMO antenna structures are compared with others by using parameters like Return Loss(RL),Voltage Standing Wave Ratio(VSWR),Radiation Pattern(RP),radiation efficiency,and directivity.The same MIMO set-up is redesigned with DGS,and the resultant parameters are compared.Finally,the Multiple Input and Multiple Output Radiating Structures with and without DGS are compared for result considerations like RL,VSWR,RP,radiation efficiency,and directivity.This projected antenna displays an omnidirectional RP with moderate gain,which is highly recommended for human healthcare applications.By introducing the defected ground structure in bottom layer the lower cut-off frequencies of 2.3,4.5 and 6.0 GHz are achieved with few biological effects on radio propagation in human body communications.The proposed design covers numerous well-known wireless standards,along with dual-function DGS slots,and it can be easily integrated into Wireless Body Area Networks(WBAN)in medical applications.This WBAN links the autonomous nodes that may be situated either in the clothes,on-body or beneath the skin of a person.This system typically advances the complete human body and the inter-connected nodes through a wireless communication channel.展开更多
Multiple approaches have been used to estimate groundwater recharge in the Upper Awash river basin. The amount of recharge reaching the Upper Awash aquifer system from the Blue Nile sub-basins is also estimated. Water...Multiple approaches have been used to estimate groundwater recharge in the Upper Awash river basin. The amount of recharge reaching the Upper Awash aquifer system from the Blue Nile sub-basins is also estimated. Water Balance, Chloride Mass Balance and HYDRUS 1D infiltration model are used to estimate recharge. A total of 29 sites were selected for the HYDRUS 1D multiple “at point” recharge simulations. Base Flow Separation (BFS) methods, using both River Analysis Package software Version 3.0.3 and Excel-based Time Plot program are also used as a proxy for recharge. Besides, overlay analysis in Processing MODFLOW, ArcGIS, and SURFER environments has been done to thoroughly consider spatial heterogeneity between any two point estimates and appreciate the effect of lineament density, topography, slope and major urbanized land on pattern of spatial distribution of recharge. Because of differences inherent in the assumptions and datasets used, the various methods employed give wide range of differences in recharge estimates. Recharge estimated for the Upper Awash basin ranges from 51.5 mm/year to 157 mm/year and for the two southern left-bank sub-basins of the Middle Blue Nile basin (Mugher and Jema) ranges from 86 mm/year to 239 mm/year. Consequently, annual average volumetric recharge in the Upper Awash and annual groundwater flux from portion of the Blue Nile sub basins to the Upper Awash aquifer system are estimated to be 983 Mm3 and 365 Mm3 respectively. The significant flux joining the Upper Awash groundwater system from part of the Middle Blue Nile basin, which is almost 37% of the total annual recharge to the Upper Awash basin makes this part of the Middle Blue Nile basin an important recharge zone for the Upper Awash groundwater. Estimating recharge using integrated approaches was found to be useful to identify range of plausible recharge rates in the two basins. Besides, the new methodological approach of superimposing recharge governing factors on interpolation of point recharge estimates helps to produce physical based spatial distribution of recharge.展开更多
Recently, if you look at the trend of the Unmanned Combat Entities (UCE) on the world that are actually operational, a large number of personnel per one UCE has been operating the GCS. However, UCEs to perform the att...Recently, if you look at the trend of the Unmanned Combat Entities (UCE) on the world that are actually operational, a large number of personnel per one UCE has been operating the GCS. However, UCEs to perform the attack/reconnaissance mission are very expensive assets and require a considerable amount of time to train for UCE operations. Accordingly, the future battlefield environment has become important to develop multiple UCE ground control station. In this study, we developed a multiple UCE GCS that one operator can operate up to four UCEs. The software was built with a total of 6 displays using a Lockheed Martin Corporation’s prepar3D. Scenario of research takes into account the operation of the South Korea-type future multiple UCEs, to take advantage of the simulation system, in this paper, we propose for each of the concepts and technologies.展开更多
BACKGROUND The incidence of malignant gastrointestinal(GI)tumors is increasing,and advancements in medical care have significantly improved patient survival rates.As a result,the number of cases involving multiple pri...BACKGROUND The incidence of malignant gastrointestinal(GI)tumors is increasing,and advancements in medical care have significantly improved patient survival rates.As a result,the number of cases involving multiple primary cancers(MPC)has also increased.The rarity of MPC and the absence of sensitive and specific dia-gnostic markers often lead to missed or incorrect diagnoses.It is,therefore,of vital importance to improve the vigilance of clinicians and the accurate diagnosis of this disease.Patients with GI malignancies face a higher relative risk of deve-loping additional primary malignant tumors compared to those with other systemic tumors.Vigilant monitoring and follow-up are crucial,especially for high-risk groups,which include older adults,men,those with addictions to alcohol and tobacco,those with a family history of tumors,and those who have undergone radiotherapy.CASE SUMMARY In this article,we report three cases of MPC,each involving malignant tumors of the GI tract as the initial primary carcinoma,offering insights that may aid in effectively managing similar cases.CONCLUSION Patients with GI malignancies face a higher MPC risk.Developing screening and follow-up protocols may enhance detection and treatment outcomes.展开更多
Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate...Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate this impulse game problem with the modified objective function including interaction costs among the players in a discontinuous fashion,and subsequently,to derive a verification theorem for identifying the feedback Nash equilibrium strategy.展开更多
Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-targe...Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-target networks(DTNs),which could provide a promising avenue in network medicine.We demonstrated the utility of the method by introducing a deep learning and network perturbation-based framework,for drug repurposing of multiple sclerosis(MS).First,the MS comorbidity network was constructed by performing a random walk with restart algorithm based on shared genes between MS and other diseases as seed nodes.Then,based on topological analysis and functional annotation,the neurotransmission module was identified as the“therapeutic module”of MS.Further,perturbation scores of drugs on the module were calculated by constructing the DTN and introducing the PRS analysis,giving a list of repurposable drugs for MS.Mechanism of action analysis both at pathway and structural levels screened dihydroergocristine as a candidate drug of MS by targeting a serotonin receptor of se-rotonin 2B receptor(HTR2B).Finally,we established a cuprizone-induced chronic mouse model to evaluate the alteration of HTR2B in mouse brain regions and observed that HTR2B was significantly reduced in the cuprizone-induced mouse cortex.These findings proved that the network perturbation modeling is a promising avenue for drug repurposing of MS.As a useful systematic method,our approach can also be used to discover the new molecular mechanism and provide effective candidate drugs for other complex diseases.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.51927808 and 41630642)the Postgraduate Innovation Fund Project of Hunan Province(Grant No.CX20200242).
文摘During the development blasting of circular tunnels, the detonation of multiple blastholes arranged onconcentric circles induces a complex dynamic response in the surrounding rocks. This process involvesmultiple blast loadings, static stress unloadings, and stress redistributions. In this study, the dynamicstresses of the surrounding rocks during development blasting, considering multiple blasting-unloadingstages with exponential paths and triangular paths (linear simplified paths of exponential paths), aresolved based on the dynamic theory and the Fourier transform method. Then, a corresponding discreteelement model is established using particle flow code (PFC). The multiple-stage dynamic stress andfracture distribution under different in situ stress levels and lateral coefficients are investigated. Theoreticalresults indicate that the peak compressive stresses in the surrounding rocks induced by bothtriangular and exponential paths are equal, while the triangular path generates greater additional dynamictensile stresses, particularly in the circumferential direction, compared to the exponential path.Numerical results show that the exponential path causes less dynamic circumferential tensile damageand forms fewer radial fractures than the triangular path in the first few blast stages;conversely, itexacerbates the damage and instability in the final blasting-unloading stage and forms more circumferentialfractures. Furthermore, the in situ stress determines which of the two opposite effects isdominant. Therefore, when using overly simplified triangular paths to evaluate the stability of surroundingrocks, potential overestimation or underestimation caused by different failure mechanismsshould be considered. Specifically, under high horizontal and vertical stresses, the static stress redistributionwith layer-by-layer blasting suppresses dynamic circumferential tensile and radial compressivedamage. The damage evolution of surrounding rocks in multi-stage blasting under different in situstresses is summarized and classified according to the damage mechanism and characteristics, which canguide blasting and support design.
基金supported by the Natural Science Foundation of Jiangsu province,China(BK20240937)the Belt and Road Special Foundation of the National Key Laboratory of Water Disaster Prevention(2022491411,2021491811)the Basal Research Fund of Central Public Welfare Scientific Institution of Nanjing Hydraulic Research Institute(Y223006).
文摘Understanding spatial heterogeneity in groundwater responses to multiple factors is critical for water resource management in coastal cities.Daily groundwater depth(GWD)data from 43 wells(2018-2022)were collected in three coastal cities in Jiangsu Province,China.Seasonal and Trend decomposition using Loess(STL)together with wavelet analysis and empirical mode decomposition were applied to identify tide-influenced wells while remaining wells were grouped by hierarchical clustering analysis(HCA).Machine learning models were developed to predict GWD,then their response to natural conditions and human activities was assessed by the Shapley Additive exPlanations(SHAP)method.Results showed that eXtreme Gradient Boosting(XGB)was superior to other models in terms of prediction performance and computational efficiency(R^(2)>0.95).GWD in Yancheng and southern Lianyungang were greater than those in Nantong,exhibiting larger fluctuations.Groundwater within 5 km of the coastline was affected by tides,with more pronounced effects in agricultural areas compared to urban areas.Shallow groundwater(3-7 m depth)responded immediately(0-1 day)to rainfall,primarily influenced by farmland and topography(slope and distance from rivers).Rainfall recharge to groundwater peaked at 50%farmland coverage,but this effect was suppressed by high temperatures(>30℃)which intensified as distance from rivers increased,especially in forest and grassland.Deep groundwater(>10 m)showed delayed responses to rainfall(1-4 days)and temperature(10-15 days),with GDP as the primary influence,followed by agricultural irrigation and population density.Farmland helped to maintain stable GWD in low population density regions,while excessive farmland coverage(>90%)led to overexploitation.In the early stages of GDP development,increased industrial and agricultural water demand led to GWD decline,but as GDP levels significantly improved,groundwater consumption pressure gradually eased.This methodological framework is applicable not only to coastal cities in China but also could be extended to coastal regions worldwide.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
基金Supported by Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau),No.2023MSXM060.
文摘BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.
文摘A multiple round quantum dense coding scheme based on the quantum phase estimation algorithm is proposed and implemented in a three qubit nuclear magnetic resonance (NMR) quantum computer. Using an m + 1 qubit system, Bob can transmit one of 2m+1 messages to Alice, through manipulating only one qubit and exchanging it between Alice and Bob for m rounds. The information capacity is enhanced to m + 1 bits as compared to m bits in a classical scheme. The scheme has been demonstrated in NMR system, and the experimental results show a good agreement between theory and experiment.
文摘The development of a multiple level underground mine is a complex task in which geology,engineering,ground control,and unit operations are integrated into a single mine design.The components are interdependent and must function cohesively to ensure a profitable underground mining operation.To optimize reserve recovery,mine planning should begin from the lowest level and progress up.This limits any misjudgments or oversights of a given level affecting the underlying levels and ensures the ability to maximize recovery from each level.Mine planning should start with the exploration and characterization of the geologic setting.Once the reserve geology and quality is well understood,then mine planning can begin with respect to the following:(1)orientation of mine works with respect to horizontal stress;(2)access to the reserve;(3)determination of opening widths;(4)selection of back,floor horizons and pillar centers;(5)selection of development and secondary mining heights;(6)appropriate inter-burden thicknesses;and(7)examining the stability of the multiple level mine through numerical modeling.The multiple level mine design process and decisions are presented through a case history example.The theme is that there is one opportunity to"get it right"and many chances to overlook a small aspect within the design that will plague the mine throughout all levels and through the entirety of its operating life.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52171250,52061135107)。
文摘Fluid resonance within narrow gaps in multiple-box systems with sharp and round inlet configurations are investigated by using the potential flow and viscous fluid flow models in the OpenFOAM^(■)package.Evident discrepancy between two numerical models can be observed for sharp inlet configurations.In addition to the dramatical decrease of resonant amplitude in narrow gaps,some peak values at the higher resonant frequencies predicted by the potential flow model even disappear in the viscous fluid flow results.The decreased normalized resonant amplitudes with the increase of incident wave amplitude can be observed for sharp inlet configurations.However,the hydrodynamic behaviors of multiple-box system with round inlet configurations between potential flow and viscous fluid flow models are quite similar with each other.The normalized resonant amplitudes are nearly independent of incident wave amplitudes for multiple-box systems with round inlet configurations.This implies that the energy dissipation associated with fluid viscosity and flow rotation plays an important role in the gap resonance for sharp inlet configurations;while it is insignificant for round inlet configurations.
基金Project supported by the National Natural Science Foundation of China(Grant No.11002086)the Shanghai Leading Academic Discipline Project(Grant No.J50103)
文摘The core of smoothed particle hydrodynamics （SPH） is the nearest neighbor search subroutine. In this paper, a nearest neighbor search algorithm which is based on multiple background grids and support variable smooth length is introduced. Through tested on lid driven cavity flow, it is clear that this method can provide high accuracy. Analysis and experiments have been made on its parallelism, and the results show that this method has better parallelism and with adding processors its accuracy become higher, thus it achieves that efficiency grows in pace with accuracy.
文摘During underground coal gasification （UCG）, whereby coal is converted to syngas in situ, a cavity is formed in the coal seam. The cavity growth rate （CGR） or the moving rate of the gasification face is affected by controllable （operation pressure, gasification time, geometry of UCG panel） and uncontrollable （coal seam properties） factors. The CGR is usually predicted by mathematical models and laboratory experiments, which are time consuming, cumbersome and expensive. In this paper, a new simple model for CGR is developed using non-linear regression analysis, based on data from 1 l UCG field trials. The empirical model compares satisfactorily with Perkins model and can reliably predict CGR.
文摘There are various analytical, empirical and numerical methods to calculate groundwater inflow into tun- nels excavated in rocky media. Analytical methods have been widely applied in prediction of groundwa- ter inflow to tunnels due to their simplicity and practical base theory. Investigations show that the real amount of water infiltrating into jointed tunnels is much less than calculated amount using analytical methods and obtained results are very dependent on tunnel＇s geometry and environmental situations. In this study, using multiple regression analysis, a new empirical model for estimation of groundwater seepage into circular tunnels was introduced. Our data was acquired from field surveys and laboratory analysis of core samples. New regression variables were defined after perusing single and two variables relationship between groundwater seepage and other variables. Finally, an appropriate model for estima- tion of leakage was obtained using the stepwise algorithm. Statistics like R, R2, R2e and the histogram of residual values in the model represent a good reputation and fitness for this model to estimate the groundwater seepage into tunnels. The new experimental model was used for the test data and results were satisfactory. Therefore, multiple regression analysis is an effective and efficient way to estimate the groundwater seeoage into tunnels.
基金the University of Tabriz through a Grant scheme No.808.
文摘An explicit model management framework is introduced for predictive Groundwater Levels(GWL),particularly suitable to Observation Wells(OWs)with sparse and possibly heterogeneous data.The framework implements Multiple Models(MM)under the architecture of organising them at levels,as follows:(i)Level 0:treat heterogeneity in the data,e.g.Self-Organised Mapping(SOM)to classify the OWs;and decide on model structure,e.g.formulate a grey box model to predict GWLs.(ii)Level 1:construct MMs,e.g.two Fuzzy Logic(FL)and one Neurofuzzy(NF)models.(iii)Level 2:formulate strategies to combine the MM at Level 1,for which the paper uses Artificial Neural Networks(Strategy 1)and simple averaging(Strategy 2).Whilst the above model management strategy is novel,a critical view is presented,according to which modelling practices are:Inclusive Multiple Modelling(IMM)practices contrasted with existing practices,branded by the paper as Exclusionary Multiple Modelling(EMM).Scientific thinking over IMMs is captured as a framework with four dimensions:Model Reuse(MR),Hierarchical Recursion(HR),Elastic Learning Environment(ELE)and Goal Orientation(GO)and these together make the acronym of RHEO.Therefore,IMM-RHEO is piloted in the aquifer of Tabriz Plain with sparse and possibly heterogeneous data.The results provide some evidence that(i)IMM at two levels improves on the accuracy of individual models;and(ii)model combinations in IMM practices bring‘model-learning’into fashion for learning with the goal to explain baseline conditions and impacts of subsequent management changes.
基金supported by the National Natural Science Foundation of China
文摘The calculations of unsteady flow to a multiple well system with the application of boundary elementmethod (BEM) are discussed. The mathematical model of unsteady well flow is a boundary value problem ofparabolic differential equation. It is changed into an elliptic one by Laplace transform to eliminate time varia-ble. The image function of water head H can be solved by BEM. We derived the boundary integral equation ofthe transformed variable H and the discretization form of it, so that there is no need to discretize the bounda-ries of well walls and it becomes easier to solve the groundwater head H by numerical inversion.
基金supported by the National Natural Science Foundation of China,Nos.82060219,82271234the Natural Science Foundation of Jiangxi Province,Nos.20212ACB216009,20212BAB216048+1 种基金Jiangxi Province Thousands of Plans,No.jxsq2019201023Youth Team Project of the Second Affiliated Hospital of Nanchang University,No.2019YNTD12003(all to FH)。
文摘Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.
文摘A credible method of calculating the detection threshold is presented for the multiple target situations, which appear frequently in the lower Doppler velocity region during the surveillance of sea with HF ground wave radar. This method defines a whole-peak-outlier elimination （WPOE） criterion, which is based on in-peak-samples correlation of each target echo spectra, to trim off the target signals and abnormal disturbances with great amplitude from the complex spectra. Therefore, cleaned background noise samples are obtained to improve the accuracy and reliability of noise level estimation. When the background noise is nonhomogeneous, the detection samples are limited and often occupied heavily with outliers. In this case, the problem that the detection threshold is overvalued can be solved. In applications on experimental data, it is verified that this method can reduce the miss alarm rate of signal detection effectively in multiple target situations as well as make the adaptability of the detector better.
文摘In this paper,the investigation of a novel compact 2×2,2×1,and 1×1 Ultra-Wide Band(UWB)based Multiple-Input Multiple-Output(MIMO)antenna with Defected Ground Structure(DGS)is employed.The proposed Electromagnetic Radiation Structures(ERS)is composed of multiple radiating elements.These MIMO antennas are designed and analyzed with and without DGS.The feeding is introduced by a microstrip-fed line to significantly moderate the radiating structure’s overall size,which is 60×40×1 mm.The high directivity and divergence characteristics are attained by introducing the microstripfed lines perpendicular to each other.And the projected MIMO antenna structures are compared with others by using parameters like Return Loss(RL),Voltage Standing Wave Ratio(VSWR),Radiation Pattern(RP),radiation efficiency,and directivity.The same MIMO set-up is redesigned with DGS,and the resultant parameters are compared.Finally,the Multiple Input and Multiple Output Radiating Structures with and without DGS are compared for result considerations like RL,VSWR,RP,radiation efficiency,and directivity.This projected antenna displays an omnidirectional RP with moderate gain,which is highly recommended for human healthcare applications.By introducing the defected ground structure in bottom layer the lower cut-off frequencies of 2.3,4.5 and 6.0 GHz are achieved with few biological effects on radio propagation in human body communications.The proposed design covers numerous well-known wireless standards,along with dual-function DGS slots,and it can be easily integrated into Wireless Body Area Networks(WBAN)in medical applications.This WBAN links the autonomous nodes that may be situated either in the clothes,on-body or beneath the skin of a person.This system typically advances the complete human body and the inter-connected nodes through a wireless communication channel.
文摘Multiple approaches have been used to estimate groundwater recharge in the Upper Awash river basin. The amount of recharge reaching the Upper Awash aquifer system from the Blue Nile sub-basins is also estimated. Water Balance, Chloride Mass Balance and HYDRUS 1D infiltration model are used to estimate recharge. A total of 29 sites were selected for the HYDRUS 1D multiple “at point” recharge simulations. Base Flow Separation (BFS) methods, using both River Analysis Package software Version 3.0.3 and Excel-based Time Plot program are also used as a proxy for recharge. Besides, overlay analysis in Processing MODFLOW, ArcGIS, and SURFER environments has been done to thoroughly consider spatial heterogeneity between any two point estimates and appreciate the effect of lineament density, topography, slope and major urbanized land on pattern of spatial distribution of recharge. Because of differences inherent in the assumptions and datasets used, the various methods employed give wide range of differences in recharge estimates. Recharge estimated for the Upper Awash basin ranges from 51.5 mm/year to 157 mm/year and for the two southern left-bank sub-basins of the Middle Blue Nile basin (Mugher and Jema) ranges from 86 mm/year to 239 mm/year. Consequently, annual average volumetric recharge in the Upper Awash and annual groundwater flux from portion of the Blue Nile sub basins to the Upper Awash aquifer system are estimated to be 983 Mm3 and 365 Mm3 respectively. The significant flux joining the Upper Awash groundwater system from part of the Middle Blue Nile basin, which is almost 37% of the total annual recharge to the Upper Awash basin makes this part of the Middle Blue Nile basin an important recharge zone for the Upper Awash groundwater. Estimating recharge using integrated approaches was found to be useful to identify range of plausible recharge rates in the two basins. Besides, the new methodological approach of superimposing recharge governing factors on interpolation of point recharge estimates helps to produce physical based spatial distribution of recharge.
文摘Recently, if you look at the trend of the Unmanned Combat Entities (UCE) on the world that are actually operational, a large number of personnel per one UCE has been operating the GCS. However, UCEs to perform the attack/reconnaissance mission are very expensive assets and require a considerable amount of time to train for UCE operations. Accordingly, the future battlefield environment has become important to develop multiple UCE ground control station. In this study, we developed a multiple UCE GCS that one operator can operate up to four UCEs. The software was built with a total of 6 displays using a Lockheed Martin Corporation’s prepar3D. Scenario of research takes into account the operation of the South Korea-type future multiple UCEs, to take advantage of the simulation system, in this paper, we propose for each of the concepts and technologies.
基金Supported by Gansu Provincial Natural Science Foundation,No.21JR1RA010In-Hospital Research Fund of Gansu Provincial Hospital,No.23GSSYD-5.
文摘BACKGROUND The incidence of malignant gastrointestinal(GI)tumors is increasing,and advancements in medical care have significantly improved patient survival rates.As a result,the number of cases involving multiple primary cancers(MPC)has also increased.The rarity of MPC and the absence of sensitive and specific dia-gnostic markers often lead to missed or incorrect diagnoses.It is,therefore,of vital importance to improve the vigilance of clinicians and the accurate diagnosis of this disease.Patients with GI malignancies face a higher relative risk of deve-loping additional primary malignant tumors compared to those with other systemic tumors.Vigilant monitoring and follow-up are crucial,especially for high-risk groups,which include older adults,men,those with addictions to alcohol and tobacco,those with a family history of tumors,and those who have undergone radiotherapy.CASE SUMMARY In this article,we report three cases of MPC,each involving malignant tumors of the GI tract as the initial primary carcinoma,offering insights that may aid in effectively managing similar cases.CONCLUSION Patients with GI malignancies face a higher MPC risk.Developing screening and follow-up protocols may enhance detection and treatment outcomes.
基金supported in part by the National Natural Science Foundation of China(62173051)the Fundamental Research Funds for the Central Universities(2024CDJCGJ012,2023CDJXY-010)+1 种基金the Chongqing Technology Innovation and Application Development Special Key Project(CSTB2022TIADCUX0015,CSTB2022TIAD-KPX0162)the China Postdoctoral Science Foundation(2024M763865)
文摘Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate this impulse game problem with the modified objective function including interaction costs among the players in a discontinuous fashion,and subsequently,to derive a verification theorem for identifying the feedback Nash equilibrium strategy.
基金supported by the National Natural Science Foundation of China(Grant Nos.:32271292,31872723,32200778,and 22377089)the Jiangsu Students Innovation and Entrepre-neurship Training Program,China(Program No.:202210285081Z)+6 种基金the Project of MOE Key Laboratory of Geriatric Diseases and Immunology,China(Project No.:JYN202404)Proj-ect Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,Natural Science Foundation of Jiangsu Province,China(Project No.:BK20220494)Suzhou Medical and Health Technology Innovation Project,China(Grant No.:SKY2022107)the Clinical Research Center of Neuro-logical Disease in The Second Affiliated Hospital of Soochow University,China(Grant No.:ND2022A04)State Key Laboratory of Drug Research(Grant No.:SKLDR-2023-KF-05)Jiangsu Shuang-chuang Program for Doctor,Young Science Talents Promotion Project of Jiangsu Science and Technology Association(Program No.:TJ-2023-019)Young Science Talents Promotion Project of Suzhou Science and Technology Association,Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,and startup funding(Grant Nos.:NH21500221,NH21500122,and NH21500123)to Qifei Cong.
文摘Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-target networks(DTNs),which could provide a promising avenue in network medicine.We demonstrated the utility of the method by introducing a deep learning and network perturbation-based framework,for drug repurposing of multiple sclerosis(MS).First,the MS comorbidity network was constructed by performing a random walk with restart algorithm based on shared genes between MS and other diseases as seed nodes.Then,based on topological analysis and functional annotation,the neurotransmission module was identified as the“therapeutic module”of MS.Further,perturbation scores of drugs on the module were calculated by constructing the DTN and introducing the PRS analysis,giving a list of repurposable drugs for MS.Mechanism of action analysis both at pathway and structural levels screened dihydroergocristine as a candidate drug of MS by targeting a serotonin receptor of se-rotonin 2B receptor(HTR2B).Finally,we established a cuprizone-induced chronic mouse model to evaluate the alteration of HTR2B in mouse brain regions and observed that HTR2B was significantly reduced in the cuprizone-induced mouse cortex.These findings proved that the network perturbation modeling is a promising avenue for drug repurposing of MS.As a useful systematic method,our approach can also be used to discover the new molecular mechanism and provide effective candidate drugs for other complex diseases.
