BACKGROUND: Although the hepatoma-specific band of gamma-glutamyltransferase ( GGT ) is a highly sensitive marker in diagnosis of hepatocellular carcinoma, the kine- tic expression and the early alterations of GGT in ...BACKGROUND: Although the hepatoma-specific band of gamma-glutamyltransferase ( GGT ) is a highly sensitive marker in diagnosis of hepatocellular carcinoma, the kine- tic expression and the early alterations of GGT in the deve- lopment of hepatoma remain unclear. In this study, we in- vestigated the expression and the alterations of GGT multi- ple molecular forms in hepatotumorigenesis. METHODS: The expression of GGT in a chemically in- duced hepatocarcinogenesis model was examined by giving 0. 05% of 2-fluoenylacetamide in diet for 12 weeks. The ex- pression levels of total RNA and GGT, and the changes of liver pathology, GGT multiple molecular forms and sugar- chain heterogeneity were investigated at the different stages of rat hepatoma development. RESULTS: Pathological examination and biochemical ana- lysis found that liver GGT was over-expressed and secreted into blood during canceration. Serum total GGT and liver GGT specific activities (IU/g) including soluble and mem- brane-combined GGT were significantly higher (P <0.05) in experimental groups than those in control group, respec- tively. A highly positive correlation was found between to- tal GGT activities and total RNA levels (r =0.90, P <0.05) of the liver. Both were higher six weeks later than before. Con A-non-reactive-GGT was increased consistantly dur- ing the development of rat hepatoma. GGT multiple mo- lecular forms in the liver and sera of experimental rats showed that fetal liver-type GGT bands were associated with the development of hepatoma. CONCLUSIONS: Fetal liver-type GGT in sera and the liver of rats is closely related to hepatotumorigenesis. It can be used as a sensitive enzymatic marker for the early diagnosis of liver cancer.展开更多
We propose and simulate a method for generating a three-dimensional （3D） optical cage in the vicinity of focus by focusing a double-ring shaped radially and azimuthally polarized beam. Our study shows that the combi...We propose and simulate a method for generating a three-dimensional （3D） optical cage in the vicinity of focus by focusing a double-ring shaped radially and azimuthally polarized beam. Our study shows that the combination of an inner ring with an azimuthally polarized field and an outer ring with a radially polarized field and a phase factor can produce an optical cage with a dark region enclosed by higher intensity. The shape of the cage can be tailored by appropriately adjusting the parameters of double-mode beams. Furthermore, multiple 3D optical cages can be realized by applying the shift theorem of the Fourier transform and macro-pixel sampling algorithm to a double-ring shaped radially and azimuthally polarized beam.展开更多
First,we prove a decomposition formula for any multiplicative differential form on a Lie groupoid G.Next,we prove that if G is a Poisson Lie groupoid,then the spaceΩ_(mult)·(G)of multiplicative forms on G has a ...First,we prove a decomposition formula for any multiplicative differential form on a Lie groupoid G.Next,we prove that if G is a Poisson Lie groupoid,then the spaceΩ_(mult)·(G)of multiplicative forms on G has a differential graded Lie algebra(DGLA)structure.Furthermore,when combined withΩ·(M),which is the space of forms on the base manifold M of G,Ω_(mult)·(G)forms a canonical DGLA crossed module.This supplements a previously known fact that multiplicative multi-vector fields on G form a DGLA crossed module with the Schouten algebraΓ(∧·A)stemming from the Lie algebroid A of G.展开更多
Purpose:The purpose of this paper is to develop a novel interval Multi-Objective Optimization by a Ratio Analysis plus the Full Multiplicative Form(MULTIMOORA)with combination weights to evaluate the employment qualit...Purpose:The purpose of this paper is to develop a novel interval Multi-Objective Optimization by a Ratio Analysis plus the Full Multiplicative Form(MULTIMOORA)with combination weights to evaluate the employment quality of college graduates,where the criteria are expressed by interval numbers and the weights of criteria are completely unknown.Design/methodology/approach:Firstly,considering the subjective uncertainty of the weights of the criteria,the interval best worst method(I-BWM)was present to determine the subjective weights of the criteria.Secondly,bythe improvedinterval numberdistance measure,an improved interval deviationmaximizationmethod(I-MDM)was introduced to detemine the objective weights.In the following,based on the I-BWM and the improved I-MDM,a combination weighting method that takes into account the subjective and objective weights is proposed.Finally,a multi-criteria decision-making method based on the interval MULTIMOORA with combination weights is present toevaluate the employment quality of college graduates,and then a comparative analysis withsome of the existing distance measures of interval numberswas conducted to illustrate the flexibility.Findings:According to the data of the Report on Employment Quality of Chinese College Graduats released by MycosResearchInstitutein2016:2020and2021:2022,theproposedmethodwasusedtoevaluate theemployment quality of college graduates during the period before and after the COVID-19 epidemic.The results verify that the method is more reasonable because the subjective and objective weights of the criteria can be fully considered.Finally,the feasibility and practicability of the proposed method are further verified by varying parameters.Originality/value:Present an evaluation method on the employment quality of college graduates based on the Interval MULTIMOORA with combination weights considering the subjective and objective weights.And the proposed method is proved that it can provide a more reasonable evaluation results.At the same time,it is verified that the feasibility and the practicability of the proposed method are affected by varying parameters in the paper.展开更多
基金This study was supported by a grant from Key Projects of Medical Sciences Department of Health , Jiangsu Province, China ( RC2003100 ).
文摘BACKGROUND: Although the hepatoma-specific band of gamma-glutamyltransferase ( GGT ) is a highly sensitive marker in diagnosis of hepatocellular carcinoma, the kine- tic expression and the early alterations of GGT in the deve- lopment of hepatoma remain unclear. In this study, we in- vestigated the expression and the alterations of GGT multi- ple molecular forms in hepatotumorigenesis. METHODS: The expression of GGT in a chemically in- duced hepatocarcinogenesis model was examined by giving 0. 05% of 2-fluoenylacetamide in diet for 12 weeks. The ex- pression levels of total RNA and GGT, and the changes of liver pathology, GGT multiple molecular forms and sugar- chain heterogeneity were investigated at the different stages of rat hepatoma development. RESULTS: Pathological examination and biochemical ana- lysis found that liver GGT was over-expressed and secreted into blood during canceration. Serum total GGT and liver GGT specific activities (IU/g) including soluble and mem- brane-combined GGT were significantly higher (P <0.05) in experimental groups than those in control group, respec- tively. A highly positive correlation was found between to- tal GGT activities and total RNA levels (r =0.90, P <0.05) of the liver. Both were higher six weeks later than before. Con A-non-reactive-GGT was increased consistantly dur- ing the development of rat hepatoma. GGT multiple mo- lecular forms in the liver and sera of experimental rats showed that fetal liver-type GGT bands were associated with the development of hepatoma. CONCLUSIONS: Fetal liver-type GGT in sera and the liver of rats is closely related to hepatotumorigenesis. It can be used as a sensitive enzymatic marker for the early diagnosis of liver cancer.
基金supported in part by the National Natural Science Foundation of China(Nos.91750202,11530046,and 11474156)the National Key R&D Program of China(No.2017YFA0303700)+1 种基金the Collaborative Innovation Center of Advanced Microstructures of Chinathe Collaborative Innovation Center of Solid-State Lighting and Energy-Saving Electronics of China
文摘We propose and simulate a method for generating a three-dimensional （3D） optical cage in the vicinity of focus by focusing a double-ring shaped radially and azimuthally polarized beam. Our study shows that the combination of an inner ring with an azimuthally polarized field and an outer ring with a radially polarized field and a phase factor can produce an optical cage with a dark region enclosed by higher intensity. The shape of the cage can be tailored by appropriately adjusting the parameters of double-mode beams. Furthermore, multiple 3D optical cages can be realized by applying the shift theorem of the Fourier transform and macro-pixel sampling algorithm to a double-ring shaped radially and azimuthally polarized beam.
基金supported by National Natural Science Foundation of China(Grant No.12071241)the National Key Research and Development Program of China(Grant No.2021YFA1002000).
文摘First,we prove a decomposition formula for any multiplicative differential form on a Lie groupoid G.Next,we prove that if G is a Poisson Lie groupoid,then the spaceΩ_(mult)·(G)of multiplicative forms on G has a differential graded Lie algebra(DGLA)structure.Furthermore,when combined withΩ·(M),which is the space of forms on the base manifold M of G,Ω_(mult)·(G)forms a canonical DGLA crossed module.This supplements a previously known fact that multiplicative multi-vector fields on G form a DGLA crossed module with the Schouten algebraΓ(∧·A)stemming from the Lie algebroid A of G.
基金supported in part by the National Natural Science Foundation of China(No.11371130)the Youth Innovation Fund of Xiamen City(3-502Z20206020).
文摘Purpose:The purpose of this paper is to develop a novel interval Multi-Objective Optimization by a Ratio Analysis plus the Full Multiplicative Form(MULTIMOORA)with combination weights to evaluate the employment quality of college graduates,where the criteria are expressed by interval numbers and the weights of criteria are completely unknown.Design/methodology/approach:Firstly,considering the subjective uncertainty of the weights of the criteria,the interval best worst method(I-BWM)was present to determine the subjective weights of the criteria.Secondly,bythe improvedinterval numberdistance measure,an improved interval deviationmaximizationmethod(I-MDM)was introduced to detemine the objective weights.In the following,based on the I-BWM and the improved I-MDM,a combination weighting method that takes into account the subjective and objective weights is proposed.Finally,a multi-criteria decision-making method based on the interval MULTIMOORA with combination weights is present toevaluate the employment quality of college graduates,and then a comparative analysis withsome of the existing distance measures of interval numberswas conducted to illustrate the flexibility.Findings:According to the data of the Report on Employment Quality of Chinese College Graduats released by MycosResearchInstitutein2016:2020and2021:2022,theproposedmethodwasusedtoevaluate theemployment quality of college graduates during the period before and after the COVID-19 epidemic.The results verify that the method is more reasonable because the subjective and objective weights of the criteria can be fully considered.Finally,the feasibility and practicability of the proposed method are further verified by varying parameters.Originality/value:Present an evaluation method on the employment quality of college graduates based on the Interval MULTIMOORA with combination weights considering the subjective and objective weights.And the proposed method is proved that it can provide a more reasonable evaluation results.At the same time,it is verified that the feasibility and the practicability of the proposed method are affected by varying parameters in the paper.
