This study aims to advance the development of magnetic fluorescent polymer microspheres for biomedical detection applications.Conventionally,dopants have utilized europium(Ⅲ)(Eu(Ⅲ))organic complexes due to their hig...This study aims to advance the development of magnetic fluorescent polymer microspheres for biomedical detection applications.Conventionally,dopants have utilized europium(Ⅲ)(Eu(Ⅲ))organic complexes due to their high compatibility with polymers and strong fluorescence.However,as the common magnetic material Fe_(3)O_(4)can quench their fluorescence,it is hard to synthesize Eu complexdoped magnetic fluorescent materials.To maintain fluorescence in the presence of magnetic parts,in this work,we synthesized Eu-doped magnetic microspheres with multi-layered structure.Firstly,poly-(glycidyl methacrylate)(PGMA)microspheres were prepared as templates and subsequently coated with layers of Fe_(3)O_(4)and SiO_(2).Then,the synthesized Eu(TTA)_(3)(TPPO)_(2)were added into PGMA@Fe_(3)O_(4)@SiO_(2)microspheres in either basic or acidic conditions,and covered them with an extra sol-gel layer of silica at the same time.The microspheres exhibit a core-shell structure with sub-micron dimensions(580 nm)and possess favorable superparamagnetic properties(M_(s)=22.02 A·m^(2)/kg,Mr=1.37 A·m^(2)/kg,H_(c)=0.242 A/m).But the fluorescence of Eu^(3+)are significantly quenched by Fe_(3)O_(4),O-H oscillators,and N-H oscillators.Finally,to exclude the quenching mentioned above,the first pure SiO_(2)shielding layer and the second Eu(TTA)_(3)(TPPO)_(2)-dispersed SiO_(2)layer were coated onto PGMA@Fe_(3)O_(4)microspheres to prevent the energy transfer due to the quenching centers and hold the fluorescence of Eu^(3+).These findings underscore the considerable potential of these microspheres exhibiting rapid magnetic separation and stable fluorescence for bioimaging and biosensing applications.展开更多
Microflowers made of interconnected MnO2 nanosheets have been successfully synthesized in a microwave reactor through a hydrothermal reduction of KMnO4 with aqueous HCI at elevated temperatures in the presence of supe...Microflowers made of interconnected MnO2 nanosheets have been successfully synthesized in a microwave reactor through a hydrothermal reduction of KMnO4 with aqueous HCI at elevated temperatures in the presence of superparamagnetic Fe3O4SiO2 core-shell nanoparticles.Due to the chemical compatibility between SiO2 and MnO2,the heterogeneous reaction leads to the spontaneous encapsulation of the Fe3O4@SiO2 core-shell nanoparticles in the MnO2 microflowers.The resulting hybrid particles exhibit multiple properties including high surface area associated with the MnO2nanosheets and superparamagnetism originated from the Fe3O4@SiO2 core-shell nanoparticles.which are beneficial for applications requiring both high surface area and magnetic separation.展开更多
Ultrafast reaction kinetics is essential for rapid detection,synthesis,and process monitoring,but the intrinsic energy barrier as a basic material property is challenging to tailor.With the involvement of nanointerfac...Ultrafast reaction kinetics is essential for rapid detection,synthesis,and process monitoring,but the intrinsic energy barrier as a basic material property is challenging to tailor.With the involvement of nanointerfacial chemistry,we propose a carbonization-based strategy for achieving ultrafast chemical reaction.In a case study,ultrafast Griess reaction within 1 min through the carbonization of N-(1-naphthalene)ethylenediamine(NETH)was realized.The carbonization-mediated ultrafast reaction is attributed to the synergic action of reduced electrostatic repulsion,enriched reactant concentration,and boosted NETH nucleophilicity.The enhanced reaction kinetics in o-phenylenediamine-Cu^(2)+and ophenylenediamine-ascorbic acid systems validate the universality of carbonization-engineered ultrafast chemical reaction strategy.The finding of this work offers a novel and simple tactic for the fabrication of multifunctional nanoparticles as ultrafast and effective nanoreactants and/or reporters in analytical,biological,and material aspects.展开更多
Accurate diagnosis of tumors needs much detailed information. However, available single imaging modality cannot provide complete or comprehensive data. Nanomedicine is the application of nanotechnology to medicine, an...Accurate diagnosis of tumors needs much detailed information. However, available single imaging modality cannot provide complete or comprehensive data. Nanomedicine is the application of nanotechnology to medicine, and multimodality imaging based on nanoparticles has been receiving extensive attention. This new hybrid imaging technology could provide complementary information from different imaging modalities using only a single injection of contrast agent. In this review, we introduce recent developments in multifunctional nanoparticles and their biomedical applications to multimodal imaging and theragnosis as nanomedicine. Most of the reviewed studies are based on the intrinsic properties of nanoparticles and their application in clinical imaging technology. The imaging techniques include positron emission tomography, single-photon emission computed tomography, computerized tomography, magnetic resonance imaging, optical imaging, and ultrasound imaging.展开更多
We report the application of a versatile diblock copolymer,poly(ethylene oxide)-b-poly(γ-methacryloxypropyl trimethoxysilane)(PEO-b-PγMPS),to prepare nanocrystals such as iron oxide nanoparticles or quantum dots,wit...We report the application of a versatile diblock copolymer,poly(ethylene oxide)-b-poly(γ-methacryloxypropyl trimethoxysilane)(PEO-b-PγMPS),to prepare nanocrystals such as iron oxide nanoparticles or quantum dots,with either a single core or multi-core cluster,for biomedical applications.This amphiphilic copolymer comprises both a hydrophilic PEO segment and a hydrophobic segment with a“surface anchoring moiety”(the silane group)which can interact effectively with the hydrophobic nanocrystals through ligand exchange.One of the unique features of this work is that we can control the formation of either single core nanoparticles or multi-core nanoclusters by simply varying the conditions of ligand exchange and aging of the mixture of block copolymer and nanoparticles without needing to change the copolymer.The morphologies of the resulting single core nanoparticles or multi-core nanoclusters were confirmed by dynamic light scattering and transmission electron microscopy.The clustered nanoparticles exhibit enhanced physicochemical properties that are beyond those expected from a simple accumulation of individual nanoparticles.Additionally,the hybrid nanoparticles containing both magnetic iron oxide nanoparticles and optical quantum dots obtained using our strategy provide have combined magnetic and optical functionalities that allow for potential new and expanded biomedical applications,as demonstrated by their use for magnetic resonance imaging and biomarker-targeted cell imaging.展开更多
The vicious cycle between tumor cell proliferation and bone resorption remarkably elevates the progression and metastasis of bone tumors.Here,we fabricated polyethylene glycol-conjugated alendronate-functionalized and...The vicious cycle between tumor cell proliferation and bone resorption remarkably elevates the progression and metastasis of bone tumors.Here,we fabricated polyethylene glycol-conjugated alendronate-functionalized and chloroquine(CQ)-loaded polydopamine nanoparticles(PPA/CQ)for efficient treatment of bone tumors via breaking the vicious cycle.The nanoparticles were efficiently accumulated to the bone tissues,especially the osteolytic lesions around tumors.CQ released from PPA/CQ inhibited osteoclastogenesis via preventing the degradation of tumor necrosis factor(TNF)receptor-associated receptor 3 to attenuate the osteolysis in bone tumors.On the other hand,CQ blocked the autophagy in cancer cells,resulting in improved photothermal killing of cancer cells.Finally,the in vivo experiment revealed that PPA/CQ-associated treatment efficiently inhibited both tumor growth and osteolysis.This work suggests that autophagy inhibition-associated photothermal therapy could be a promising strategy for treating malignant bone tumors.展开更多
Hyperthermia has long been considered as an adjuvant therapy for treating various diseases. Cancer treatment exploiting hyperthermia shows great clinical potential for a wide range of tumors. Importantly, the efficacy...Hyperthermia has long been considered as an adjuvant therapy for treating various diseases. Cancer treatment exploiting hyperthermia shows great clinical potential for a wide range of tumors. Importantly, the efficacy of hyperthermal therapy has recently been enhanced by the development of functional nanomaterials. The unique physicochemical properties of nanomaterials afford the specific localization of hyperthermia to primary tumors and early-stage cancers. In particular, due to their high rate of light-to-heat conversion and their capacity to be activated by tissue-penetrating electromagnetic radiation, near-infrared （NIR） light-absorbing plasmonic nanomaterials have attracted considerable attention as candidates for noninvasive photothermal therapy. The purpose of this article is to provide a overview on the current development in multifunctional nanomaterials capable of combined hyperthermia-chemotherapy delivery.展开更多
Correction to:Sci China Chem,2025,68(10):5086-5096.https://doi.org/10.1007/s11426-025-2730-2 We regret that our article“Smart formation of multifunctional glyco-nanoparticles:glycoclusters delivering NIR photosensiti...Correction to:Sci China Chem,2025,68(10):5086-5096.https://doi.org/10.1007/s11426-025-2730-2 We regret that our article“Smart formation of multifunctional glyco-nanoparticles:glycoclusters delivering NIR photosensitizers for enhanced cell imaging and photodynamic therapy”(Sci China Chem,2025,68:5086-5096)contained errors.Specifically,the image in Figure 6d exhibiting the phototoxicity of control group at 0μM was inadvertently taken the incorrect image in the original paper.The correction version is given below.Nevertheless,this correction does not affect the results and conclusion of the paper.展开更多
Recently,nano theranostics,by integrating diagnostic and therapeutic functions into a nano system,have provided increasing opportunities for the design of personalized medicine in cancer.Among the construction method ...Recently,nano theranostics,by integrating diagnostic and therapeutic functions into a nano system,have provided increasing opportunities for the design of personalized medicine in cancer.Among the construction method of various theranostic nano systems,the design of single component nanoparticles which are composed of organic photosensitive dyes has become a promising approach to constructing multifunctional nano-theranostic systems,thanks to its unique advantages such as defined structure,100%loading,and high repeatability.Specifically,depending on the inherent photonic imaging and therapeutic properties of the photosensitive dyes,the multifunctional purpose which integrates theranostic effects and targeting abilities can be realized via reasonable molecular modification and supramolecular assembly.In this review,recent advances in the development of nanostructured self-assemblies of porphyrins,phthalocyanines,and boron-dipyrromethanes for theranostics are summarized.Emphasis on their design consideration and theranostic applications are presented.Additionally,prospects for clinical practice and potential challenges of this rapidly growing field are also provided.展开更多
基金Project supported by the"Leading Goose"R&D Program(2022C01142)of Zhejiang Provincethe National Key R&D Program of China(2022YFB3503700)。
文摘This study aims to advance the development of magnetic fluorescent polymer microspheres for biomedical detection applications.Conventionally,dopants have utilized europium(Ⅲ)(Eu(Ⅲ))organic complexes due to their high compatibility with polymers and strong fluorescence.However,as the common magnetic material Fe_(3)O_(4)can quench their fluorescence,it is hard to synthesize Eu complexdoped magnetic fluorescent materials.To maintain fluorescence in the presence of magnetic parts,in this work,we synthesized Eu-doped magnetic microspheres with multi-layered structure.Firstly,poly-(glycidyl methacrylate)(PGMA)microspheres were prepared as templates and subsequently coated with layers of Fe_(3)O_(4)and SiO_(2).Then,the synthesized Eu(TTA)_(3)(TPPO)_(2)were added into PGMA@Fe_(3)O_(4)@SiO_(2)microspheres in either basic or acidic conditions,and covered them with an extra sol-gel layer of silica at the same time.The microspheres exhibit a core-shell structure with sub-micron dimensions(580 nm)and possess favorable superparamagnetic properties(M_(s)=22.02 A·m^(2)/kg,Mr=1.37 A·m^(2)/kg,H_(c)=0.242 A/m).But the fluorescence of Eu^(3+)are significantly quenched by Fe_(3)O_(4),O-H oscillators,and N-H oscillators.Finally,to exclude the quenching mentioned above,the first pure SiO_(2)shielding layer and the second Eu(TTA)_(3)(TPPO)_(2)-dispersed SiO_(2)layer were coated onto PGMA@Fe_(3)O_(4)microspheres to prevent the energy transfer due to the quenching centers and hold the fluorescence of Eu^(3+).These findings underscore the considerable potential of these microspheres exhibiting rapid magnetic separation and stable fluorescence for bioimaging and biosensing applications.
基金supported by the U.S.Department of Energy,Office of Science,Office of Basic Energy Sciences,under Contract No.DE-AC02-06CH11357
文摘Microflowers made of interconnected MnO2 nanosheets have been successfully synthesized in a microwave reactor through a hydrothermal reduction of KMnO4 with aqueous HCI at elevated temperatures in the presence of superparamagnetic Fe3O4SiO2 core-shell nanoparticles.Due to the chemical compatibility between SiO2 and MnO2,the heterogeneous reaction leads to the spontaneous encapsulation of the Fe3O4@SiO2 core-shell nanoparticles in the MnO2 microflowers.The resulting hybrid particles exhibit multiple properties including high surface area associated with the MnO2nanosheets and superparamagnetism originated from the Fe3O4@SiO2 core-shell nanoparticles.which are beneficial for applications requiring both high surface area and magnetic separation.
基金supported by the National Natural Science Foundation of China(Nos.82160153,21505162,22074005,and 22101027)Natural Science Foundation of Hunan Province,China(No.2022SK2102)+1 种基金Hunan Provincial Department of Education Scientific Research Project(No.240994)the Natural Science Foundation of Beijing Municipality(No.2202038).
文摘Ultrafast reaction kinetics is essential for rapid detection,synthesis,and process monitoring,but the intrinsic energy barrier as a basic material property is challenging to tailor.With the involvement of nanointerfacial chemistry,we propose a carbonization-based strategy for achieving ultrafast chemical reaction.In a case study,ultrafast Griess reaction within 1 min through the carbonization of N-(1-naphthalene)ethylenediamine(NETH)was realized.The carbonization-mediated ultrafast reaction is attributed to the synergic action of reduced electrostatic repulsion,enriched reactant concentration,and boosted NETH nucleophilicity.The enhanced reaction kinetics in o-phenylenediamine-Cu^(2)+and ophenylenediamine-ascorbic acid systems validate the universality of carbonization-engineered ultrafast chemical reaction strategy.The finding of this work offers a novel and simple tactic for the fabrication of multifunctional nanoparticles as ultrafast and effective nanoreactants and/or reporters in analytical,biological,and material aspects.
文摘Accurate diagnosis of tumors needs much detailed information. However, available single imaging modality cannot provide complete or comprehensive data. Nanomedicine is the application of nanotechnology to medicine, and multimodality imaging based on nanoparticles has been receiving extensive attention. This new hybrid imaging technology could provide complementary information from different imaging modalities using only a single injection of contrast agent. In this review, we introduce recent developments in multifunctional nanoparticles and their biomedical applications to multimodal imaging and theragnosis as nanomedicine. Most of the reviewed studies are based on the intrinsic properties of nanoparticles and their application in clinical imaging technology. The imaging techniques include positron emission tomography, single-photon emission computed tomography, computerized tomography, magnetic resonance imaging, optical imaging, and ultrasound imaging.
基金work is supported in part by the Emory Molecular Translational Imaging Center with an in vivo Cellular and Molecular Imaging Center grant(ICMIC,No.P50CA128301-01A10003)from the National Cancer Institute(NCI)the Emory-Georgia Tech Nanotechnology Center for Personalized and Predictive Oncology with a grant from the Center of Cancer Nanotechnology Excellence(CCNE,No.U54CA119338-01)from NCI and a research grant from EmTech Bio,Inc.
文摘We report the application of a versatile diblock copolymer,poly(ethylene oxide)-b-poly(γ-methacryloxypropyl trimethoxysilane)(PEO-b-PγMPS),to prepare nanocrystals such as iron oxide nanoparticles or quantum dots,with either a single core or multi-core cluster,for biomedical applications.This amphiphilic copolymer comprises both a hydrophilic PEO segment and a hydrophobic segment with a“surface anchoring moiety”(the silane group)which can interact effectively with the hydrophobic nanocrystals through ligand exchange.One of the unique features of this work is that we can control the formation of either single core nanoparticles or multi-core nanoclusters by simply varying the conditions of ligand exchange and aging of the mixture of block copolymer and nanoparticles without needing to change the copolymer.The morphologies of the resulting single core nanoparticles or multi-core nanoclusters were confirmed by dynamic light scattering and transmission electron microscopy.The clustered nanoparticles exhibit enhanced physicochemical properties that are beyond those expected from a simple accumulation of individual nanoparticles.Additionally,the hybrid nanoparticles containing both magnetic iron oxide nanoparticles and optical quantum dots obtained using our strategy provide have combined magnetic and optical functionalities that allow for potential new and expanded biomedical applications,as demonstrated by their use for magnetic resonance imaging and biomarker-targeted cell imaging.
基金the National Natural Science Foundation of China(21725402,31871010,81971735,81871470 and 81901867)Shanghai Municipal Science and Technology Commission(17XD1401600)+1 种基金the Fok Ying Tong Education Foundation(151036)Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06C322)。
文摘The vicious cycle between tumor cell proliferation and bone resorption remarkably elevates the progression and metastasis of bone tumors.Here,we fabricated polyethylene glycol-conjugated alendronate-functionalized and chloroquine(CQ)-loaded polydopamine nanoparticles(PPA/CQ)for efficient treatment of bone tumors via breaking the vicious cycle.The nanoparticles were efficiently accumulated to the bone tissues,especially the osteolytic lesions around tumors.CQ released from PPA/CQ inhibited osteoclastogenesis via preventing the degradation of tumor necrosis factor(TNF)receptor-associated receptor 3 to attenuate the osteolysis in bone tumors.On the other hand,CQ blocked the autophagy in cancer cells,resulting in improved photothermal killing of cancer cells.Finally,the in vivo experiment revealed that PPA/CQ-associated treatment efficiently inhibited both tumor growth and osteolysis.This work suggests that autophagy inhibition-associated photothermal therapy could be a promising strategy for treating malignant bone tumors.
文摘Hyperthermia has long been considered as an adjuvant therapy for treating various diseases. Cancer treatment exploiting hyperthermia shows great clinical potential for a wide range of tumors. Importantly, the efficacy of hyperthermal therapy has recently been enhanced by the development of functional nanomaterials. The unique physicochemical properties of nanomaterials afford the specific localization of hyperthermia to primary tumors and early-stage cancers. In particular, due to their high rate of light-to-heat conversion and their capacity to be activated by tissue-penetrating electromagnetic radiation, near-infrared （NIR） light-absorbing plasmonic nanomaterials have attracted considerable attention as candidates for noninvasive photothermal therapy. The purpose of this article is to provide a overview on the current development in multifunctional nanomaterials capable of combined hyperthermia-chemotherapy delivery.
文摘Correction to:Sci China Chem,2025,68(10):5086-5096.https://doi.org/10.1007/s11426-025-2730-2 We regret that our article“Smart formation of multifunctional glyco-nanoparticles:glycoclusters delivering NIR photosensitizers for enhanced cell imaging and photodynamic therapy”(Sci China Chem,2025,68:5086-5096)contained errors.Specifically,the image in Figure 6d exhibiting the phototoxicity of control group at 0μM was inadvertently taken the incorrect image in the original paper.The correction version is given below.Nevertheless,this correction does not affect the results and conclusion of the paper.
基金supported by the National Natural Science Foundation of China(Grant Nos.22078066 and 22178065)
文摘Recently,nano theranostics,by integrating diagnostic and therapeutic functions into a nano system,have provided increasing opportunities for the design of personalized medicine in cancer.Among the construction method of various theranostic nano systems,the design of single component nanoparticles which are composed of organic photosensitive dyes has become a promising approach to constructing multifunctional nano-theranostic systems,thanks to its unique advantages such as defined structure,100%loading,and high repeatability.Specifically,depending on the inherent photonic imaging and therapeutic properties of the photosensitive dyes,the multifunctional purpose which integrates theranostic effects and targeting abilities can be realized via reasonable molecular modification and supramolecular assembly.In this review,recent advances in the development of nanostructured self-assemblies of porphyrins,phthalocyanines,and boron-dipyrromethanes for theranostics are summarized.Emphasis on their design consideration and theranostic applications are presented.Additionally,prospects for clinical practice and potential challenges of this rapidly growing field are also provided.
