Mesenchymal stem cells(MSC)are particularly effective in promoting cartilage regeneration due to their immunomodulatory,anti-inflammatory and regenerative repair functions of tissues and organs.Meanwhile,the intra-art...Mesenchymal stem cells(MSC)are particularly effective in promoting cartilage regeneration due to their immunomodulatory,anti-inflammatory and regenerative repair functions of tissues and organs.Meanwhile,the intra-articular delivery and synergy with other therapeutic drugs have been the key issues driving their further application.We report a mussel-inspired multifunctional hydrogel system,which could achieve co-delivery and synergism effect of MSC-derived exosomes(Exos)with icariin(ICA).The ICA and Exos co-delivered articular cavity injection system are expected to retain in the joint cavity and promote cartilage regeneration,due to the thermosensitive,self-healing and adhesion properties of the mussel-inspired multifunctional hydrogel.The experimental results proved that Exos enhanced the cellular uptake of ICA by more than 2-fold evenly,and the synergism of Exos and ICA efficiently improve the cell proliferation and migration.After synergic treatment,the content of matrix metalloproteinase 13 in the supernatant and intracellular decreased by 47%and 59%,respectively.In vivo study,ICA-loaded Exos exhibited prolonged retention behavior bymultifunctional hydrogel delivery,thus displayed an increased cartilage protection.In the model of osteoarthritis,co-delivery hydrogel system relieved the cartilage recession,ensuring appropriate cartilage thickness.展开更多
The treatment of diabetic wounds(DWs)poses a significant medical challenge.Mesenchymal stem cell-derived small extracellular vesicles(sEVs)have demonstrated potential in accelerating healing by delivering growth facto...The treatment of diabetic wounds(DWs)poses a significant medical challenge.Mesenchymal stem cell-derived small extracellular vesicles(sEVs)have demonstrated potential in accelerating healing by delivering growth factors and microRNAs.However,the rapid clearance by the circulatory system limits their concentration and bioavailability within cells.This study employed magnesium-doped bioactive glass(MgBG)to autonomously program sEVs into a vesicle cluster(EPPM),which was subsequently incorporated into a hydrogel to create a comprehensive repair system that enhanced the delivery of both sEVs and MgBG,thereby promoting rapid healing of diabetic wounds.This hydrogel exhibited excellent injectable,self-healing and bioadhesive properties,making it an ideal physical barrier for DWs.In addition,the hydrogels also possessed photoresponsive properties that facilitated their bactericidal activity.The released EPPM significantly increased the intracellular uptake and accumulation of sEVs,with approximately 8.2-fold enhancement in macrophages and 16.7-fold in endothelial cells.The EPPM clusters efficiently induce macrophage M2 polarization,reduce inflammatory responses at the wound site,and recruit cells,thereby promoting angiogenesis and collagen deposition.This integrated repair system provided a new platform for the comprehensive treatment of diabetic wounds。展开更多
Bacterial infection,tissue hypoxia and inflammatory response can hinder the infected wound repair process.To mitigate the above issues,tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets(MoS2@TA/Fe NSs)w...Bacterial infection,tissue hypoxia and inflammatory response can hinder the infected wound repair process.To mitigate the above issues,tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets(MoS2@TA/Fe NSs)with dual enzyme activities were developed and anchored to a multifunctional hydrogel.The hydrogel exhibited excellent antibacterial ability owing to the combined effects of photothermal therapy(PTT),glutathione(GSH)loss,and the peroxidase(POD)-like activity(catalyse H2O_(2)into⋅OH under acid condition)of MoS2@TA/Fe NSs.Benefitting from the catalase(CAT)-like activity,the hydrogel could decompose H2O_(2)into O_(2)at neutral pH to relieve hypoxia and supply adequate O_(2).POD-like activity was mainly attributed to MoS2 NSs,while CAT-like activity was primarily due to TA/Fe complex.Moreover,MoS2@TA/Fe NSs endowed the hydrogel with outstanding anti-oxidant ability to scavenge redundant reactive oxygen species(ROS)and reactive nitrogen species(RNS)under neutral environment to maintain the balance of antioxidant systems and prevent inflammation.In addition,the hydrogel could inhibit the release of inflammatory factors for the anti-inflammatory property of TA.TA retained partial phenolic hydroxyl groups,which cross-linked the nanosheets to the network structure of the hydrogel and promoted the adhesion of hydrogels.Due to the dynamic boron ester bonds between polyvinyl alcohol(PVA),dextran(Dex),MoS2@TA/Fe,and borax,the hydrogel demonstrated fast self-healing and rapid shape adaptability.This shape-adaptable adhesive hydrogel could fill the whole wound and closely contact the wound,ensuring that it achieved its functions with maximum efficiency.The MoS2@TA/Fe nanozyme-anchored multifunctional hydrogel showed high potential for bacteria-infected wound healing.展开更多
Flexibility and multifunctionality are now becoming inevitable worldwide tendencies for electronic devices to meet modern life's convenience,efficiency,and quality demand.To that end,developing flexible and wearab...Flexibility and multifunctionality are now becoming inevitable worldwide tendencies for electronic devices to meet modern life's convenience,efficiency,and quality demand.To that end,developing flexible and wearable energy storage devices is a must.Recently,aqueous zinc-ion batteries(ZIBs)and zinc-ion capacitors(ZICs)stand out as two of the most potent candidates for wearable electronics due to their excellent electrochemical performance,intrinsic safety,low cost,and functional controllability.Simultaneously,polymer electrolytes'introduction and rational design,especially various hydrogels,have endowed conventional ZIBs and ZICs with colorful functions,which has been regarded as a perfect answer for energy suppliers integrated into those advanced wearable electronic devices.This review focuses on the functional hydrogel electrolytes(HEs)and their application for ZIBs and ZICs.Previously reported HEs for ZIBs and ZICs were classified and analyzed,from the flexibility to mechanical endurance,temperature adaptability,electrochemical stability,and finally cell-level ZIBs and ZICs based on multifunctional HEs.Besides introducing the diverse and exciting functions of HEs,working principles were also analyzed.Ultimately,all the details of these examples were summarized,and the related challenges,constructive solutions,and futural prospects of functional ZIBs and ZICs were also dedicatedly evaluated.展开更多
Photothermal hydrogels with excellent photo responsive and thermal conversion ability had attract a great deal of attention from researchers to explore their biological applications.This review aimed to provide a comp...Photothermal hydrogels with excellent photo responsive and thermal conversion ability had attract a great deal of attention from researchers to explore their biological applications.This review aimed to provide a comprehensive overview of photothermal hydrogels,focusing on their design principles,various functions,and biological applications.Firstly,several classifications of photothermal hydrogels were given according to different photothermal agents(metal,metal sulfide/oxide,MXene,carbon-based,dyes,black phosphorus,and polymer)utilized in hydrogel construction.The photothermal conversion mechanism and hydrogel fabrication were also discussed in detail.Then,the relationship between their photothermal conversion property and functions,together with some indispensable property such as biocompatibility,adhesion,mechanical properties,and self-healing properties was fully introduced.Furthermore,the ap-plications of photothermal hydrogels in the biomedical(i.e.,wound healing,antibacterial treatments,con-trolled drug release,bone repair,and tumor treatment)was summarized.Finally,the future opportunities and challenges of photothermal hydrogels were proposed.We believe that this review could provide a new horizon for further preparation of photothermal hydrogels,and could promote their applications in widerfields.展开更多
Excessive production of reactive oxygen species(ROS)and bacterial infection are intractable obstacles for wound healing in diabetic foot ulcers.Here,we devised a novel approach using a multifunctional hydrogel to achi...Excessive production of reactive oxygen species(ROS)and bacterial infection are intractable obstacles for wound healing in diabetic foot ulcers.Here,we devised a novel approach using a multifunctional hydrogel to achieve self-cascade glucose depletion and ROS scavenging,thereby modifying the diabetic wound microenvironment.In this study,using polyvinyl alcohol(PVA),borax,oligomeric proanthocyanidins(OPC),and nanozymes(AuPt@PDA),a PVA/Borax/OPC/AuPt@PDA(PBON)hydrogel was prepared by a one-step process.The PBON hydrogel combined with near-infrared(NIR)treatment can match the complicated and changeable microenvironment in the diabetic high-mobility region through glucose depletion,ROS scavenging,photothermal therapy(photothermal conversion 81.9%),and deformation adaptation,thus promoting wound healing close to the hip in diabetic mice through angiogenesis and epidermal regeneration by collagen deposition.This approach provides a simple,safe,and efficient treatment for diabetic wounds in mobile regions.展开更多
Effective treatment of intervertebral disc degeneration with biomaterials remains a challenge,owing to the difficulty in simultaneously overcoming oxidative stress and its associated cascades in the nucleus pulposus m...Effective treatment of intervertebral disc degeneration with biomaterials remains a challenge,owing to the difficulty in simultaneously overcoming oxidative stress and its associated cascades in the nucleus pulposus microenvironment,which includes cellular senescence,apoptosis,inflammation,and extracellular matrix(ECM)degradation.To address these issues,a multifunctional hydrogel(HG-QNT)loaded with transforming growth factorβ1(TGFβ1)and quercetin-based nanoparticles(QUNPs)is developed through borate ester bonding and Schiffbase reaction-induced crosslinking.Specifically,QUNPs fabricated via coordination and hydrophobic interactions endow the hydrogel with extraordinary antioxidative properties.Benefiting from the multi-dynamic crosslinking,the hydrogel achieves self-healing,mechanical stability,and pH-responsive release of QUNPs and TGFβ1.The HG-QNT hydrogel is demonstrated to enhance the proliferation of encapsulated nucleus pulposus cells,thereby providing an ideal platform for cell transplantation.The cooperative antioxidation of QUNPs and the hydrogel carrier renders HG-QNT effective in mitigating oxidative stress,resulting in the suppression of cellular senescence,mitochondrial dysfunction,apoptosis,excessive inflammation,and abnormal catabolism.Afterwards,TGFβ1 and QUNPs act in synergy with the hydrogel to restore the anabolic/catabolic balance by enhancing ECM synthesis.Overall,the strategy orchestrating multiple modulation by HG-QNT hydrogel shows great potential for application in intervertebral disc regeneration.展开更多
X.Li,J.Gao,L.Gao,et al.,“Self-Aggregation-Induced Polymerization for Constructing Multifunctional Dynamic Zwitterionic Hydrogels,”Aggregate 6(2025):e70227.There was a graphical error in the chemical structures prese...X.Li,J.Gao,L.Gao,et al.,“Self-Aggregation-Induced Polymerization for Constructing Multifunctional Dynamic Zwitterionic Hydrogels,”Aggregate 6(2025):e70227.There was a graphical error in the chemical structures presented in Figure 1b and the Graphical Abstract.Figure 1b and the Graphical Abstract have been corrected to reflect the accurate chemical structure.展开更多
Flexible and perceptive sensors represent the pinnacle of wearable technology;nevertheless, most of the current hydrogel-based sensors encounter difficulties in concurrently achieving mechanical durability, biocompati...Flexible and perceptive sensors represent the pinnacle of wearable technology;nevertheless, most of the current hydrogel-based sensors encounter difficulties in concurrently achieving mechanical durability, biocompatibility, high sensitivity, and scalability. This work introduces an innovative multimodal hydrogel–textile composite sensor(WPU–ChCl hydrogel) developed using the free radical polymerization of acrylamide, integrating choline chloride(ChCl), EMIM TFSI ionic liquid, and waterborne polyurethane(WPU) to overcome existing constraints. The resultant hydrogel demonstrates a synergistic network of covalent and dynamic non-covalent connections, with remarkable stretchability(~900%), mechanical toughness(>250 kJ/m^(3)), and ionic conductivity(9.2 m S/cm at 600% strain). Comprehensive morphological and chemical analysis validated uniform structure, increased segmental ordering, and improved heat stability. The hydrogel exhibited swift strain responsiveness(gauge factor = 7.23), quick response/recovery times(~108/114 ms), exceptional durability over 500 cycles, and enhanced selfhealing and adherence to various surfaces. Into textiles, the composite demonstrated exceptional real-time touch and motion detection capabilities and retained sensing accuracy after 20 wash cycles. Code transmission and machine learningbased high-accuracy gesture recognition(93.65%) were examples of advanced uses. The wireless-enabled system demonstrated efficacy in IoT-based health monitoring, soft robotics, and human–machine interactions, representing a substantial advancement in next-generation wearable electronics.展开更多
The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluron...The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluronate(HA),Rhein,and Zn^(2+)(denoted as HRZn hydrogel)for enhanced deep burn wound healing.The HRZn hydrogel was readily prepared by directly mixing HA,Rhein,and Zn^(2+)and formed through a synergistic combination of in situ mineralization and dynamic crosslinking processes.Notably,we showed that Zn^(2+)could effectively induce the formation of Rhein nanofibers with the assistance of HA.This unique structure not only strengthened the hydrogel’s mechanical properties,but also endowed the HRZn hydrogel with sustained release ability towards Rhein and Zn^(2+).Leveraging the synergistic effects of Rhein and Zn^(2+),the HRZn hydrogel exhibited potent antimicrobial,anti-inflammatory,and pro-angiogenic properties.In vivo experiments demonstrated its efficacy in promoting the healing of Staphylococcus aureus(S.aureus)-infected deep burn wounds,highlighting its potential as an advanced wound dressing.Overall,this study presents a promising strategy for the development of multifunctional hydrogels tailored for the treatment of complex burn injuries.展开更多
Meniscal injury,a prevalent and challenging medical condition,is characterized by poor self-healing potential and a complex microenvironment.Tissue engineering scaffolds,particularly those made of silk fibroin(SF)/hya...Meniscal injury,a prevalent and challenging medical condition,is characterized by poor self-healing potential and a complex microenvironment.Tissue engineering scaffolds,particularly those made of silk fibroin(SF)/hyaluronic acid methacryloyl(HAMA)and encapsulating Mg^(2+),are promising options for meniscal repair.However,the inflammatory response following implantation is a significant concern.In this study,we prepared a composite SF/HAMA-Mg hydrogel scaffold,evaluated its physical and chemical properties,and detected its fibrochondrogenic differentiation effect in vitro and the healing effect in a rabbit meniscus defect model in vivo.Our results showed that the scaffold differentiates pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages after implantation,thereby reducing inflammation and facilitating the growth and repair of meniscus tissue.Further,the composite scaffold provided a conducive milieu for cell proliferation,anticipatory differentiation,and generation of extracellular matrix.In summary,composite SF/HAMA-Mg scaffolds exhibit exceptional biocompatibility and anti-inflammatory properties,demonstrating superior potential for meniscal repair.展开更多
Autologous and allogeneic bone grafts remain the gold standard for repairing bone defects.However,donor shortages and postoperative infections contribute to unsatisfactory treatment outcomes.Tissue engineering technol...Autologous and allogeneic bone grafts remain the gold standard for repairing bone defects.However,donor shortages and postoperative infections contribute to unsatisfactory treatment outcomes.Tissue engineering technology that utilizes biologically active composites to accelerate the healing and reconstruction of segmental bone defects has led to new ideas for in situ bone repair.Multifunctional nanocomposite hydrogels were constructed by covalently binding silver(Ag^(+))core-embedded mesoporous silica nanoparticles(Ag@MSN)to bone morphogenetic protein-2(BMP-2),which was encapsulated into silk fibroin methacryloyl(SilMA)and photo-crosslinked to form an Ag@MSN-BMP-2/SilMA hydrogel to preserve the biological activity of BMP-2 and slow its release.More importantly,multifunctional Ag^(+)-containing nanocomposite hydrogels showed antibacterial properties.These hydrogels possessed synergistic osteogenic and antibacterial effects to promote bone defect repair.Ag@MSN-BMP-2/SilMA exhibited good biocompatibility in vitro and in vivo owing to its interconnected porosity and improved hydrophilicity.Furthermore,the multifunctional nanocomposite hydrogel showed controllable sustained-release activity that promoted bone regeneration in repairing rat skull defects by inducing osteogenic differentiation and neovascularization.Overall,Ag@MSN-BMP-2/SilMA hydrogels enrich bone regeneration strategies and show great potential for bone regeneration.展开更多
Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial infection.As such,it is highly desired to design a nanocomposite hydrogel with ...Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial infection.As such,it is highly desired to design a nanocomposite hydrogel with excellent antibacterial activity to achieve high wound closure effectiveness.Here,based on ultrasound-triggered piezocatalytic therapy,a multifunctional hydrogel is designed to promote bacteria-infected wound healing.Under ultrasonic vibration,the surface of barium titanate(BaTiO_(3),BT)nanoparticles embedded in the hydrogel rapidly generate reactive oxygen species(ROS)owing to the established strong built-in electric field,endowing the hydrogel with superior antibacterial efficacy.This modality shows intriguing advantages over conventional photodynamic therapy,such as prominent soft tissue penetration ability and the avoidance of serious skin phototoxicity after systemic administration of photosensitizers.Moreover,the hydrogel based on N-[tris(hydroxymethyl)methyl]acrylamide(THM),N-(3-aminopropyl)methacrylamide hydrochloride(APMH)and oxidized hyaluronic acid(OHA)exhibits outstanding self-healing and bioadhesive properties able to accelerate full-thickness skin wound healing.Notably,compared with the widely reported mussel-inspired adhesive hydrogels,OHA/THM-APMH hydrogel due to the multiple hydrogen bonds from unique tri-hydroxyl structure overcomes the shortage that catechol groups are easily oxidized,giving it long-term and repeatable adhesion performance.Importantly,this hybrid hydrogel confines BT nanoparticles to wound area and locally induced piezoelectric catalysis under ultrasound to eradicate bacteria,markedly improving the therapeutic biosafety and exhibits great potential for harmless treatment of bacteria-infected tissues.展开更多
The repair and motor functional recovery after spinal cord injury(SCI)remains a worldwide challenge.The inflammatory microenvironment is one of main obstacles on inhibiting the recovery of SCI.Using mesenchymal stem c...The repair and motor functional recovery after spinal cord injury(SCI)remains a worldwide challenge.The inflammatory microenvironment is one of main obstacles on inhibiting the recovery of SCI.Using mesenchymal stem cells(MSCs)derived extracellular vesicles to replace MSCs transplantation and mimic cell paracrine secretions provides a potential strategy for microenvironment regulation.However,the effective preservation and controlled release of extracellular vesicles in the injured spinal cord tissue are still not satisfied.Herein,we fabricated an injectable adhesive anti-inflammatory F127-polycitrate-polyethyleneimine hydrogel(FE)with sustainable and long term extracellular vesicle release(FE@EVs)for improving motor functional recovery after SCI.The orthotopic injection of FE@EVs hydrogel could encapsulate extracellular vesicles on the injured spinal cord,thereby synergistically induce efficient integrated regulation through suppressing fibrotic scar formation,reducing inflammatory reaction,promoting remyelination and axonal regeneration.This study showed that combining extracellular vesicles into bioactive multifunctional hydrogel should have great potential in achieving satisfactory locomotor recovery of central nervous system diseases.展开更多
Bacterial infection is a vital factor to delay the wound healing process.The antibiotics abuse leads to drug resistance of some pathogenic bacteria.Non-antibiotic-dependent multifunctional biomaterials with accelerate...Bacterial infection is a vital factor to delay the wound healing process.The antibiotics abuse leads to drug resistance of some pathogenic bacteria.Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired.Herein,we reported a composite antibacterial hydrogel PDA-PAM/Mg^(2+)that shows excellent self-healing and tissue adhesive property,and photothermal antibacterial functions for accelerating wound healing.The gel was composed of polyacrylamide(PAM),polydopamine(PDA),and magnesium(Mg^(2+))and prepared via a two-step procedure:an alkali-induced dopamine pre-polymerization and followed radical polymerization process.The composite gel shows excellent tissue adhesiveness and Mg^(2+)-synergized photothermal antibacterial activity,inducing a survival rate of 5.29% for S.aureus and 7.06%for E.coli after near infrared light irradiation.The composite hydrogel further demonstrated efficient bacteria inhibition,enhanced wound healing and collagen deposition in a full-thickness skin defect rat model.Together,the PDA-PAM/Mg^(2+) hydrogel presents an excellent wound dressing with excellent tissue adhesion,wound healing,and antibacterial functions.展开更多
文摘Mesenchymal stem cells(MSC)are particularly effective in promoting cartilage regeneration due to their immunomodulatory,anti-inflammatory and regenerative repair functions of tissues and organs.Meanwhile,the intra-articular delivery and synergy with other therapeutic drugs have been the key issues driving their further application.We report a mussel-inspired multifunctional hydrogel system,which could achieve co-delivery and synergism effect of MSC-derived exosomes(Exos)with icariin(ICA).The ICA and Exos co-delivered articular cavity injection system are expected to retain in the joint cavity and promote cartilage regeneration,due to the thermosensitive,self-healing and adhesion properties of the mussel-inspired multifunctional hydrogel.The experimental results proved that Exos enhanced the cellular uptake of ICA by more than 2-fold evenly,and the synergism of Exos and ICA efficiently improve the cell proliferation and migration.After synergic treatment,the content of matrix metalloproteinase 13 in the supernatant and intracellular decreased by 47%and 59%,respectively.In vivo study,ICA-loaded Exos exhibited prolonged retention behavior bymultifunctional hydrogel delivery,thus displayed an increased cartilage protection.In the model of osteoarthritis,co-delivery hydrogel system relieved the cartilage recession,ensuring appropriate cartilage thickness.
基金the National Natural Science Foundation of China (Grant No. 52272276, 52073103, 52203164)the Fundamental Research Funds for the Central Universities (No. 2022ZYGXZR105)+1 种基金the Project funded by China Postdoctoral Science Foundation (No. 2022M711183)the Science and Technology Planning Project of Guangzhou (2023A04J0971).
文摘The treatment of diabetic wounds(DWs)poses a significant medical challenge.Mesenchymal stem cell-derived small extracellular vesicles(sEVs)have demonstrated potential in accelerating healing by delivering growth factors and microRNAs.However,the rapid clearance by the circulatory system limits their concentration and bioavailability within cells.This study employed magnesium-doped bioactive glass(MgBG)to autonomously program sEVs into a vesicle cluster(EPPM),which was subsequently incorporated into a hydrogel to create a comprehensive repair system that enhanced the delivery of both sEVs and MgBG,thereby promoting rapid healing of diabetic wounds.This hydrogel exhibited excellent injectable,self-healing and bioadhesive properties,making it an ideal physical barrier for DWs.In addition,the hydrogels also possessed photoresponsive properties that facilitated their bactericidal activity.The released EPPM significantly increased the intracellular uptake and accumulation of sEVs,with approximately 8.2-fold enhancement in macrophages and 16.7-fold in endothelial cells.The EPPM clusters efficiently induce macrophage M2 polarization,reduce inflammatory responses at the wound site,and recruit cells,thereby promoting angiogenesis and collagen deposition.This integrated repair system provided a new platform for the comprehensive treatment of diabetic wounds。
基金This work was supported by the National Natural Science Foundation of China(grant numbers 21878247)Key Program of the National Natural Science Foundation of China(grant numbers 21838009)+2 种基金National Key Research and Development Program(2019YFA0905200)and Xi’an Science and Technology Project(20191422315KYPT014JC016)The authors thank Dr.J.C.Li(School of Chemical Engineering,Northwest University,Xi’an,China)for improving the manuscript during revising.
文摘Bacterial infection,tissue hypoxia and inflammatory response can hinder the infected wound repair process.To mitigate the above issues,tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets(MoS2@TA/Fe NSs)with dual enzyme activities were developed and anchored to a multifunctional hydrogel.The hydrogel exhibited excellent antibacterial ability owing to the combined effects of photothermal therapy(PTT),glutathione(GSH)loss,and the peroxidase(POD)-like activity(catalyse H2O_(2)into⋅OH under acid condition)of MoS2@TA/Fe NSs.Benefitting from the catalase(CAT)-like activity,the hydrogel could decompose H2O_(2)into O_(2)at neutral pH to relieve hypoxia and supply adequate O_(2).POD-like activity was mainly attributed to MoS2 NSs,while CAT-like activity was primarily due to TA/Fe complex.Moreover,MoS2@TA/Fe NSs endowed the hydrogel with outstanding anti-oxidant ability to scavenge redundant reactive oxygen species(ROS)and reactive nitrogen species(RNS)under neutral environment to maintain the balance of antioxidant systems and prevent inflammation.In addition,the hydrogel could inhibit the release of inflammatory factors for the anti-inflammatory property of TA.TA retained partial phenolic hydroxyl groups,which cross-linked the nanosheets to the network structure of the hydrogel and promoted the adhesion of hydrogels.Due to the dynamic boron ester bonds between polyvinyl alcohol(PVA),dextran(Dex),MoS2@TA/Fe,and borax,the hydrogel demonstrated fast self-healing and rapid shape adaptability.This shape-adaptable adhesive hydrogel could fill the whole wound and closely contact the wound,ensuring that it achieved its functions with maximum efficiency.The MoS2@TA/Fe nanozyme-anchored multifunctional hydrogel showed high potential for bacteria-infected wound healing.
基金supported by the Natural Sciences and Engineering Research Council of Canada(NSERC),through the Discovery Grant Program(RGPIN-2018-06725)the Discovery Accelerator Supplement Grant Program(RGPAS-2018-522651)+1 种基金by the New Frontiers in Research Fund-Exploration Program(NFRFE-2019-00488)support from the Canada First Research Excellence Fund as part of the University of Alberta's Future Energy Systems research initiative(FES-T06-Q03).
文摘Flexibility and multifunctionality are now becoming inevitable worldwide tendencies for electronic devices to meet modern life's convenience,efficiency,and quality demand.To that end,developing flexible and wearable energy storage devices is a must.Recently,aqueous zinc-ion batteries(ZIBs)and zinc-ion capacitors(ZICs)stand out as two of the most potent candidates for wearable electronics due to their excellent electrochemical performance,intrinsic safety,low cost,and functional controllability.Simultaneously,polymer electrolytes'introduction and rational design,especially various hydrogels,have endowed conventional ZIBs and ZICs with colorful functions,which has been regarded as a perfect answer for energy suppliers integrated into those advanced wearable electronic devices.This review focuses on the functional hydrogel electrolytes(HEs)and their application for ZIBs and ZICs.Previously reported HEs for ZIBs and ZICs were classified and analyzed,from the flexibility to mechanical endurance,temperature adaptability,electrochemical stability,and finally cell-level ZIBs and ZICs based on multifunctional HEs.Besides introducing the diverse and exciting functions of HEs,working principles were also analyzed.Ultimately,all the details of these examples were summarized,and the related challenges,constructive solutions,and futural prospects of functional ZIBs and ZICs were also dedicatedly evaluated.
基金the support of the General Project of Sichuan Natural Science Foundation(No.2022NSFSC0349)National Natural Science Foundation of China Youth Fund Project(No.5180316).
文摘Photothermal hydrogels with excellent photo responsive and thermal conversion ability had attract a great deal of attention from researchers to explore their biological applications.This review aimed to provide a comprehensive overview of photothermal hydrogels,focusing on their design principles,various functions,and biological applications.Firstly,several classifications of photothermal hydrogels were given according to different photothermal agents(metal,metal sulfide/oxide,MXene,carbon-based,dyes,black phosphorus,and polymer)utilized in hydrogel construction.The photothermal conversion mechanism and hydrogel fabrication were also discussed in detail.Then,the relationship between their photothermal conversion property and functions,together with some indispensable property such as biocompatibility,adhesion,mechanical properties,and self-healing properties was fully introduced.Furthermore,the ap-plications of photothermal hydrogels in the biomedical(i.e.,wound healing,antibacterial treatments,con-trolled drug release,bone repair,and tumor treatment)was summarized.Finally,the future opportunities and challenges of photothermal hydrogels were proposed.We believe that this review could provide a new horizon for further preparation of photothermal hydrogels,and could promote their applications in widerfields.
基金supported by the National Natural Science Foundation of China (No. U1804198) to MHYZhongyuan Thousand Talents Project (No. 204200510013) to FXG+1 种基金Key Scientific and Technological Research Projects in Henan Province (No. 232102311098) to RMJthe Center for Modern Analysis and Gene Sequencing, Zhengzhou University, for the facility support.
文摘Excessive production of reactive oxygen species(ROS)and bacterial infection are intractable obstacles for wound healing in diabetic foot ulcers.Here,we devised a novel approach using a multifunctional hydrogel to achieve self-cascade glucose depletion and ROS scavenging,thereby modifying the diabetic wound microenvironment.In this study,using polyvinyl alcohol(PVA),borax,oligomeric proanthocyanidins(OPC),and nanozymes(AuPt@PDA),a PVA/Borax/OPC/AuPt@PDA(PBON)hydrogel was prepared by a one-step process.The PBON hydrogel combined with near-infrared(NIR)treatment can match the complicated and changeable microenvironment in the diabetic high-mobility region through glucose depletion,ROS scavenging,photothermal therapy(photothermal conversion 81.9%),and deformation adaptation,thus promoting wound healing close to the hip in diabetic mice through angiogenesis and epidermal regeneration by collagen deposition.This approach provides a simple,safe,and efficient treatment for diabetic wounds in mobile regions.
基金supported by the National Natural Science Foun-dation of China(Grant No.52073103,52272276,51873069,and 52373128)Beijing Municipal Health Commission(BMHC-2021-6,BJRITO-RDP-2024)Beijing Municipal Public Welfare Devel-opment and Reform Pilot Project for Medical Research Institutes(JYY2023-11,JYY2023-8).
文摘Effective treatment of intervertebral disc degeneration with biomaterials remains a challenge,owing to the difficulty in simultaneously overcoming oxidative stress and its associated cascades in the nucleus pulposus microenvironment,which includes cellular senescence,apoptosis,inflammation,and extracellular matrix(ECM)degradation.To address these issues,a multifunctional hydrogel(HG-QNT)loaded with transforming growth factorβ1(TGFβ1)and quercetin-based nanoparticles(QUNPs)is developed through borate ester bonding and Schiffbase reaction-induced crosslinking.Specifically,QUNPs fabricated via coordination and hydrophobic interactions endow the hydrogel with extraordinary antioxidative properties.Benefiting from the multi-dynamic crosslinking,the hydrogel achieves self-healing,mechanical stability,and pH-responsive release of QUNPs and TGFβ1.The HG-QNT hydrogel is demonstrated to enhance the proliferation of encapsulated nucleus pulposus cells,thereby providing an ideal platform for cell transplantation.The cooperative antioxidation of QUNPs and the hydrogel carrier renders HG-QNT effective in mitigating oxidative stress,resulting in the suppression of cellular senescence,mitochondrial dysfunction,apoptosis,excessive inflammation,and abnormal catabolism.Afterwards,TGFβ1 and QUNPs act in synergy with the hydrogel to restore the anabolic/catabolic balance by enhancing ECM synthesis.Overall,the strategy orchestrating multiple modulation by HG-QNT hydrogel shows great potential for application in intervertebral disc regeneration.
文摘X.Li,J.Gao,L.Gao,et al.,“Self-Aggregation-Induced Polymerization for Constructing Multifunctional Dynamic Zwitterionic Hydrogels,”Aggregate 6(2025):e70227.There was a graphical error in the chemical structures presented in Figure 1b and the Graphical Abstract.Figure 1b and the Graphical Abstract have been corrected to reflect the accurate chemical structure.
文摘Flexible and perceptive sensors represent the pinnacle of wearable technology;nevertheless, most of the current hydrogel-based sensors encounter difficulties in concurrently achieving mechanical durability, biocompatibility, high sensitivity, and scalability. This work introduces an innovative multimodal hydrogel–textile composite sensor(WPU–ChCl hydrogel) developed using the free radical polymerization of acrylamide, integrating choline chloride(ChCl), EMIM TFSI ionic liquid, and waterborne polyurethane(WPU) to overcome existing constraints. The resultant hydrogel demonstrates a synergistic network of covalent and dynamic non-covalent connections, with remarkable stretchability(~900%), mechanical toughness(>250 kJ/m^(3)), and ionic conductivity(9.2 m S/cm at 600% strain). Comprehensive morphological and chemical analysis validated uniform structure, increased segmental ordering, and improved heat stability. The hydrogel exhibited swift strain responsiveness(gauge factor = 7.23), quick response/recovery times(~108/114 ms), exceptional durability over 500 cycles, and enhanced selfhealing and adherence to various surfaces. Into textiles, the composite demonstrated exceptional real-time touch and motion detection capabilities and retained sensing accuracy after 20 wash cycles. Code transmission and machine learningbased high-accuracy gesture recognition(93.65%) were examples of advanced uses. The wireless-enabled system demonstrated efficacy in IoT-based health monitoring, soft robotics, and human–machine interactions, representing a substantial advancement in next-generation wearable electronics.
基金supported by the National Natural Science Foundation of China(Nos.52222307 and 52303214)the Department of Science and Technology of Jilin Province(No.20230204086YY).
文摘The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluronate(HA),Rhein,and Zn^(2+)(denoted as HRZn hydrogel)for enhanced deep burn wound healing.The HRZn hydrogel was readily prepared by directly mixing HA,Rhein,and Zn^(2+)and formed through a synergistic combination of in situ mineralization and dynamic crosslinking processes.Notably,we showed that Zn^(2+)could effectively induce the formation of Rhein nanofibers with the assistance of HA.This unique structure not only strengthened the hydrogel’s mechanical properties,but also endowed the HRZn hydrogel with sustained release ability towards Rhein and Zn^(2+).Leveraging the synergistic effects of Rhein and Zn^(2+),the HRZn hydrogel exhibited potent antimicrobial,anti-inflammatory,and pro-angiogenic properties.In vivo experiments demonstrated its efficacy in promoting the healing of Staphylococcus aureus(S.aureus)-infected deep burn wounds,highlighting its potential as an advanced wound dressing.Overall,this study presents a promising strategy for the development of multifunctional hydrogels tailored for the treatment of complex burn injuries.
基金supported by grants from the Beijing Natural Science Foundation,China(No.7244431)the Postdoctoral Science Foundation of China(No.2022M710260)the National Natural Science Foundation of China(No.82202723).
文摘Meniscal injury,a prevalent and challenging medical condition,is characterized by poor self-healing potential and a complex microenvironment.Tissue engineering scaffolds,particularly those made of silk fibroin(SF)/hyaluronic acid methacryloyl(HAMA)and encapsulating Mg^(2+),are promising options for meniscal repair.However,the inflammatory response following implantation is a significant concern.In this study,we prepared a composite SF/HAMA-Mg hydrogel scaffold,evaluated its physical and chemical properties,and detected its fibrochondrogenic differentiation effect in vitro and the healing effect in a rabbit meniscus defect model in vivo.Our results showed that the scaffold differentiates pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages after implantation,thereby reducing inflammation and facilitating the growth and repair of meniscus tissue.Further,the composite scaffold provided a conducive milieu for cell proliferation,anticipatory differentiation,and generation of extracellular matrix.In summary,composite SF/HAMA-Mg scaffolds exhibit exceptional biocompatibility and anti-inflammatory properties,demonstrating superior potential for meniscal repair.
基金supported by grants from the 512 Talents Development Project of Bengbu Medical College(Grant Nos by51202302 and by51202309)the Domestic Visiting and Training Program for Outstanding Young Backbone Teachers in High Schools(Grant No.gxgnfx2022036)+2 种基金the Natural Science Research Project of the Anhui Educational Committee(Grant Nos KJ2021ZD0089 and 2022AH020086)the Scientific Research Foundation of Bengbu Medical College(Grant No.2021bypd006)the Distinguished Young Scholars of First Affiliated Hospital of Bengbu Medical College(Grant No.2021byyfyjq01).
文摘Autologous and allogeneic bone grafts remain the gold standard for repairing bone defects.However,donor shortages and postoperative infections contribute to unsatisfactory treatment outcomes.Tissue engineering technology that utilizes biologically active composites to accelerate the healing and reconstruction of segmental bone defects has led to new ideas for in situ bone repair.Multifunctional nanocomposite hydrogels were constructed by covalently binding silver(Ag^(+))core-embedded mesoporous silica nanoparticles(Ag@MSN)to bone morphogenetic protein-2(BMP-2),which was encapsulated into silk fibroin methacryloyl(SilMA)and photo-crosslinked to form an Ag@MSN-BMP-2/SilMA hydrogel to preserve the biological activity of BMP-2 and slow its release.More importantly,multifunctional Ag^(+)-containing nanocomposite hydrogels showed antibacterial properties.These hydrogels possessed synergistic osteogenic and antibacterial effects to promote bone defect repair.Ag@MSN-BMP-2/SilMA exhibited good biocompatibility in vitro and in vivo owing to its interconnected porosity and improved hydrophilicity.Furthermore,the multifunctional nanocomposite hydrogel showed controllable sustained-release activity that promoted bone regeneration in repairing rat skull defects by inducing osteogenic differentiation and neovascularization.Overall,Ag@MSN-BMP-2/SilMA hydrogels enrich bone regeneration strategies and show great potential for bone regeneration.
基金supported by Jiangsu Provincial Key Medical Center(No.YXZXA2016009)National Key Research and Development Program of China(No.2017YFA0701301)+2 种基金National Natural Science Foundation of China(No.22205127,21875101 and 22175085)Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX22-0030)Jiangsu Funding Program for Excellent Postdoctoral Talent(NO.2022ZB692)。
文摘Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial infection.As such,it is highly desired to design a nanocomposite hydrogel with excellent antibacterial activity to achieve high wound closure effectiveness.Here,based on ultrasound-triggered piezocatalytic therapy,a multifunctional hydrogel is designed to promote bacteria-infected wound healing.Under ultrasonic vibration,the surface of barium titanate(BaTiO_(3),BT)nanoparticles embedded in the hydrogel rapidly generate reactive oxygen species(ROS)owing to the established strong built-in electric field,endowing the hydrogel with superior antibacterial efficacy.This modality shows intriguing advantages over conventional photodynamic therapy,such as prominent soft tissue penetration ability and the avoidance of serious skin phototoxicity after systemic administration of photosensitizers.Moreover,the hydrogel based on N-[tris(hydroxymethyl)methyl]acrylamide(THM),N-(3-aminopropyl)methacrylamide hydrochloride(APMH)and oxidized hyaluronic acid(OHA)exhibits outstanding self-healing and bioadhesive properties able to accelerate full-thickness skin wound healing.Notably,compared with the widely reported mussel-inspired adhesive hydrogels,OHA/THM-APMH hydrogel due to the multiple hydrogen bonds from unique tri-hydroxyl structure overcomes the shortage that catechol groups are easily oxidized,giving it long-term and repeatable adhesion performance.Importantly,this hybrid hydrogel confines BT nanoparticles to wound area and locally induced piezoelectric catalysis under ultrasound to eradicate bacteria,markedly improving the therapeutic biosafety and exhibits great potential for harmless treatment of bacteria-infected tissues.
基金supported by National Natural Science Foundation of China(Grant No.51872224,81772379,81972096 and 81902238)Zhejiang Province Health Foundation,China(Grant No.2018KY092,WKJ-ZJ-1903)Nature Science Foundation of Zhejiang Province,China(Grant No.LQ18H060003).
文摘The repair and motor functional recovery after spinal cord injury(SCI)remains a worldwide challenge.The inflammatory microenvironment is one of main obstacles on inhibiting the recovery of SCI.Using mesenchymal stem cells(MSCs)derived extracellular vesicles to replace MSCs transplantation and mimic cell paracrine secretions provides a potential strategy for microenvironment regulation.However,the effective preservation and controlled release of extracellular vesicles in the injured spinal cord tissue are still not satisfied.Herein,we fabricated an injectable adhesive anti-inflammatory F127-polycitrate-polyethyleneimine hydrogel(FE)with sustainable and long term extracellular vesicle release(FE@EVs)for improving motor functional recovery after SCI.The orthotopic injection of FE@EVs hydrogel could encapsulate extracellular vesicles on the injured spinal cord,thereby synergistically induce efficient integrated regulation through suppressing fibrotic scar formation,reducing inflammatory reaction,promoting remyelination and axonal regeneration.This study showed that combining extracellular vesicles into bioactive multifunctional hydrogel should have great potential in achieving satisfactory locomotor recovery of central nervous system diseases.
基金supported by the National Natural Science Foundation of China(No.51773130,52073216 and 51903172)National Science Foundation of Zhejiang province(LY20B040004).
文摘Bacterial infection is a vital factor to delay the wound healing process.The antibiotics abuse leads to drug resistance of some pathogenic bacteria.Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired.Herein,we reported a composite antibacterial hydrogel PDA-PAM/Mg^(2+)that shows excellent self-healing and tissue adhesive property,and photothermal antibacterial functions for accelerating wound healing.The gel was composed of polyacrylamide(PAM),polydopamine(PDA),and magnesium(Mg^(2+))and prepared via a two-step procedure:an alkali-induced dopamine pre-polymerization and followed radical polymerization process.The composite gel shows excellent tissue adhesiveness and Mg^(2+)-synergized photothermal antibacterial activity,inducing a survival rate of 5.29% for S.aureus and 7.06%for E.coli after near infrared light irradiation.The composite hydrogel further demonstrated efficient bacteria inhibition,enhanced wound healing and collagen deposition in a full-thickness skin defect rat model.Together,the PDA-PAM/Mg^(2+) hydrogel presents an excellent wound dressing with excellent tissue adhesion,wound healing,and antibacterial functions.
