OBJECTIVE:To eliminate ineffective or interfering compounds from the eight absorbed compounds(8ACs),identify the primary ACs that represent the multifunctional therapeutic effects of Zhiqiao(Fructus Aurantii Submaturu...OBJECTIVE:To eliminate ineffective or interfering compounds from the eight absorbed compounds(8ACs),identify the primary ACs that represent the multifunctional therapeutic effects of Zhiqiao(Fructus Aurantii Submaturus)and Houpo(Cortex Magnoliae Officinalis)(FM),along with elucidating their underlying mechanisms.METHODS:Key multifunctional ACs were screened through ex vivo-to-in vitro extrapolation(ex vivo dose=serum concentration)and validated in vivo,with efficacy assessed via contribution(dose=FM content).Functional magnetic resonance imaging analyzed brain regions's blood oxygen level-dependent(BOLD)changes,and the molecular mechanisms were analyzed by transcriptome of the dentate gyrus(DG).RESULTS:The results showed that representative 2ACs(Nobiletin+Magnolol)and 3ACs(Nobiletin+Magnolol+Meranzin hydrate)screened on ex vivo experiment by the criteria of contribution ranking contributed 80.72%-126.74%of the antidepressant and prokinetic effects of the FM(improvement of depressive-like behaviours,gastrointestinal disorder,monoamine neurotransmitters,ghrelin,endocrine hormones,pro-inflammatory factors,oxidative stress indicators).In addition,3ACs demonstrated superiority over 2ACs in improving depression and levels of multiple stress mediators.Zhiqiao(Fructus Aurantii Submaturus)(FRA)reduced acute stress-induced hyperactivation of the cingulate cortex,thalamus,hypothalamus,and entorhinal cortex and elevated BOLD signaling in the insular cortex,temporal association cortex.Furthermore,FRA upregulated pathways of neurotransmitter receptor activity and serotonergic synaptic function and downregulated inflammation-related pathways at the genetic level.CONCLUSION:2ACs and 3ACs closely reflected FM's multifunctional effect in antidepressant and prokinetic.FRA restores stress-impaired neural connectivity in functional brain regions and improves synaptic plasticity and neurogenesis at the genetic level.展开更多
A novel β-cyclodextrin(β-CD)derivative bearing diethanolamine moiety was synthesized by a convenient method with 63% yield,and the new host compound was characterized by (13)~C-NMR,FT-IR spectra etc,
A Convenient method for the synthesis of fused phosphorusheterocycle 1,3,2-oxazaphosphorin-[3.2-a]-8-oxo-10-thio(or seleno)-[1,3,2]-benzodiazaphosphorines was carried out in one pot by the reaction of Tris(diethylamin...A Convenient method for the synthesis of fused phosphorusheterocycle 1,3,2-oxazaphosphorin-[3.2-a]-8-oxo-10-thio(or seleno)-[1,3,2]-benzodiazaphosphorines was carried out in one pot by the reaction of Tris(diethylamino)phosphine with multifunctional compounds 2-(N-(beta or gamma-hydroxyl) alkylene) amino-benzamides 1. When PCL3 was used, only chlorinated product was obtained.展开更多
Multifunctional compounds have attracted significant attention due to their wide-ranging applications in advanced technologies.In this study,we synthesized two semiconductor hybrid Cd/Hg-selenidostannates,(H_(2)BPP)_(...Multifunctional compounds have attracted significant attention due to their wide-ranging applications in advanced technologies.In this study,we synthesized two semiconductor hybrid Cd/Hg-selenidostannates,(H_(2)BPP)_(2)CdSn_(3)Se_(9) and(H_(2)DMP)_(2)Hg_(4)Sn_(4)Se_(15),employing 1,3-bis(4-piperidinyl)propane and 1,5-diamino-2-methylpentane through a surfactant-assisted thermal method.Remarkably,these hybrid chalcogenides are highly soluble in DMF,facilitating the formation of smooth,pinhole-free thin films via a spin-coating method.(H_(2)BPP)_(2)CdSn_(3)Se_(9) and(H_(2)DMP)_(2)Hg_(4)Sn_(4)Se_(15) films exhibit exceptional stability under high humidity and heat,with semiconducting band gaps of 2.12 eV and 2.21 eV,respectively.These band gaps enable strong light absorption and charge carrier generation,which directly contribute to their significant photocurrent responses.Specifically,photocurrent measurements show Ilight values of 1.5μA cm^(-2) and 1μA cm^(-2) at 0.8 V for(H_(2)BPP)_(2)CdSn_(3)Se_(9) and(H_(2)DMP)_(2)Hg_(4)Sn_(4)Se_(15),notably higher than the 0.30μA cm^(-2) observed for the commercially available SnSe_(2) electrode under the same conditions.Building on these interesting electrical properties,(H_(2)BPP)_(2)CdSn_(3)Se_(9) also showed notable piezoelectric properties,resulting from its unique structural framework that supports both efficient charge transport and mechanical responsiveness.These promising stability and multifunctional characteristics highlight the potential of these hybrid selenidostannates for advanced optoelectronic and piezoelectric applications.展开更多
基金Supported by the Jiangsu Province’s Colleges and Universities(Integration of Chinese and Western Medicine)the National Natural Science Foundation of China[Methanism on Molecular and Hippocampus-Thalamus Neurocircuitry of Rapid Prokinetic and Antidepressant by Shugan Following Acute Stress(81973589)]The Relationship Between Stress,Ghrelin Signaling,Liver-Soothing and Antidepressant Prokinetic Mechanisms(81573797)。
文摘OBJECTIVE:To eliminate ineffective or interfering compounds from the eight absorbed compounds(8ACs),identify the primary ACs that represent the multifunctional therapeutic effects of Zhiqiao(Fructus Aurantii Submaturus)and Houpo(Cortex Magnoliae Officinalis)(FM),along with elucidating their underlying mechanisms.METHODS:Key multifunctional ACs were screened through ex vivo-to-in vitro extrapolation(ex vivo dose=serum concentration)and validated in vivo,with efficacy assessed via contribution(dose=FM content).Functional magnetic resonance imaging analyzed brain regions's blood oxygen level-dependent(BOLD)changes,and the molecular mechanisms were analyzed by transcriptome of the dentate gyrus(DG).RESULTS:The results showed that representative 2ACs(Nobiletin+Magnolol)and 3ACs(Nobiletin+Magnolol+Meranzin hydrate)screened on ex vivo experiment by the criteria of contribution ranking contributed 80.72%-126.74%of the antidepressant and prokinetic effects of the FM(improvement of depressive-like behaviours,gastrointestinal disorder,monoamine neurotransmitters,ghrelin,endocrine hormones,pro-inflammatory factors,oxidative stress indicators).In addition,3ACs demonstrated superiority over 2ACs in improving depression and levels of multiple stress mediators.Zhiqiao(Fructus Aurantii Submaturus)(FRA)reduced acute stress-induced hyperactivation of the cingulate cortex,thalamus,hypothalamus,and entorhinal cortex and elevated BOLD signaling in the insular cortex,temporal association cortex.Furthermore,FRA upregulated pathways of neurotransmitter receptor activity and serotonergic synaptic function and downregulated inflammation-related pathways at the genetic level.CONCLUSION:2ACs and 3ACs closely reflected FM's multifunctional effect in antidepressant and prokinetic.FRA restores stress-impaired neural connectivity in functional brain regions and improves synaptic plasticity and neurogenesis at the genetic level.
文摘A novel β-cyclodextrin(β-CD)derivative bearing diethanolamine moiety was synthesized by a convenient method with 63% yield,and the new host compound was characterized by (13)~C-NMR,FT-IR spectra etc,
文摘A Convenient method for the synthesis of fused phosphorusheterocycle 1,3,2-oxazaphosphorin-[3.2-a]-8-oxo-10-thio(or seleno)-[1,3,2]-benzodiazaphosphorines was carried out in one pot by the reaction of Tris(diethylamino)phosphine with multifunctional compounds 2-(N-(beta or gamma-hydroxyl) alkylene) amino-benzamides 1. When PCL3 was used, only chlorinated product was obtained.
基金supported by the National Natural Science Foundation of China(No.W2433042 and 22375157)the State Key Laboratory of Electrical Insulation and Power Equipment(No.EIPE23409)+5 种基金the Programme of Introducing Talents of Discipline to Universities(B23025)the Medical-Engineering Cross Project of the First Affiliated Hospital of XJTU(QYJC02)the Key Scientific and Technological Innovation Team of Shaanxi Province(No.2020TD-001)the Fundamental Research Funds for Central Universities(No.xtr052023002)the“Scientists engineers”Team Building Project of Qin Chuang Yuan in Shaanxi Province of China(2022KXJ-088)the Instrument Analysis Center of Xi’an Jiaotong University for assistance.
文摘Multifunctional compounds have attracted significant attention due to their wide-ranging applications in advanced technologies.In this study,we synthesized two semiconductor hybrid Cd/Hg-selenidostannates,(H_(2)BPP)_(2)CdSn_(3)Se_(9) and(H_(2)DMP)_(2)Hg_(4)Sn_(4)Se_(15),employing 1,3-bis(4-piperidinyl)propane and 1,5-diamino-2-methylpentane through a surfactant-assisted thermal method.Remarkably,these hybrid chalcogenides are highly soluble in DMF,facilitating the formation of smooth,pinhole-free thin films via a spin-coating method.(H_(2)BPP)_(2)CdSn_(3)Se_(9) and(H_(2)DMP)_(2)Hg_(4)Sn_(4)Se_(15) films exhibit exceptional stability under high humidity and heat,with semiconducting band gaps of 2.12 eV and 2.21 eV,respectively.These band gaps enable strong light absorption and charge carrier generation,which directly contribute to their significant photocurrent responses.Specifically,photocurrent measurements show Ilight values of 1.5μA cm^(-2) and 1μA cm^(-2) at 0.8 V for(H_(2)BPP)_(2)CdSn_(3)Se_(9) and(H_(2)DMP)_(2)Hg_(4)Sn_(4)Se_(15),notably higher than the 0.30μA cm^(-2) observed for the commercially available SnSe_(2) electrode under the same conditions.Building on these interesting electrical properties,(H_(2)BPP)_(2)CdSn_(3)Se_(9) also showed notable piezoelectric properties,resulting from its unique structural framework that supports both efficient charge transport and mechanical responsiveness.These promising stability and multifunctional characteristics highlight the potential of these hybrid selenidostannates for advanced optoelectronic and piezoelectric applications.
