Aim To investigate the chemical constituents from Potentilla multifida L..Methods Chromatographic technique was employed for the isolation and purification of theconstituents, and the structures were identified by spe...Aim To investigate the chemical constituents from Potentilla multifida L..Methods Chromatographic technique was employed for the isolation and purification of theconstituents, and the structures were identified by spectral evidence. Results Four compounds wereisolated involving ade-nosine (1), apigenin-6-C-arabinopyranosyl-8-C-glucopyranoside (2),apigenin-7-O-β-D-glucuronide (3) and luteolin-7-O-β-D-glucuronide (4). Conclusion The fourcompounds were obtained from the genus Potentilla for the first time.展开更多
Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.Methods:The methanolic stem bark extract of Jatroph...Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.Methods:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses lo obtain three known metabolites,microcyclic lathyrane dilerpenoids(1-3).Structures were confirmed by comparison of 1D and 2D spectral data with literature.Results:The three compounds exhibited inhibition of antileishmanial,antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC_(50)of 82 and 8.7 μg/ml,respectively.Conclusions:The research lends support to the ethnomedicinal use of the plant in combating microbial infections,leishmaniasis and malarial infections.展开更多
Biebersteinia multifida DC. has been used for the purpose of development of physical strength in iranian folk medicine. In the present study, we investigated the effect of Biebersteinia multifida DC. root extract on p...Biebersteinia multifida DC. has been used for the purpose of development of physical strength in iranian folk medicine. In the present study, we investigated the effect of Biebersteinia multifida DC. root extract on performance of the Forced Swimming Test (FST), and on blood biochemical parameters related to fatigue: Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), Glucose (Glc), and Total Protein (TP). Biebersteinia multifida DC. root extract was orally administered to mice at the doses 4, 7 and 10 mg/kg continuously once per day for 1 and 7 days using a feeding atraumatic needle. After 7 days, on FST the immobility time was decreased in the treated-groups at the doses 4 and 7 mg/kg, but after 1 day, only the immobility time of the treated- group at the dose of 4 mg/kg was decreased significantly. In addition, the content of Glc and TP in the blood serum was significantly increased in the groups receiving 4 and 7 mg/kg of Biebersteinia multifida DC. root extract for 7 days and LDH was decreased significantly. However, the levels of BUN and CK did not show a significant change. The results predict a potential benefit of Biebersteinia multifida DC. root extract as an anti-fatigue treatment and for improving physical stamina.展开更多
Introduction: Jatropha multifida Lin was a plant of traditional Beninese medicine used as an antibiotic. This study aimed to evaluate the antibacterial activity and the toxicity of the sap and the aqueous extract of J...Introduction: Jatropha multifida Lin was a plant of traditional Beninese medicine used as an antibiotic. This study aimed to evaluate the antibacterial activity and the toxicity of the sap and the aqueous extract of Jatropha multifida leaves. Methods: Phytochemical screening of Jatropha multifida leaves was carried out. The extract was obtained by maceration. The antimicrobial activity of sap and leaves was evaluated on the five strains of hospital germs. Acute oral toxicity by forced gavage in a single dose of 2000 mg/kg body weight was performed on female Wistar rats. Biochemical and hematological parameters were determined. Results: The presence of flavonoids, tannins, alkaloids, anthocyanins, mucilages, leuco-anthocyanins and saponosides was noted in the leaves of Jatropha multifida. The aqueous extracts of the leaves inhibited two strains of Staphylococcus aureus out of three, while the sap of Jatropha multifida was 100% bactericidal against the strains of Staphylococcus aureus and Streptococcus D. The sap and aqueous leaf extract were not bactericidal on strains of Escherichia coli, Klebsiella oxytoca and Pseudomonas aeruginosa. For the toxicity, there was no death of rats and the aqueous extract of the leaves did not significantly vary the weight of the rats, the creatinine, the ALAT transaminase, the hemoglobin level, the number of white blood cells and blood platelets. Conclusion: The sap of Jatropha multifida exerted a more effective antibacterial activity than the aqueous extract of its leaves. The leaves were not acutely toxic.展开更多
文摘Aim To investigate the chemical constituents from Potentilla multifida L..Methods Chromatographic technique was employed for the isolation and purification of theconstituents, and the structures were identified by spectral evidence. Results Four compounds wereisolated involving ade-nosine (1), apigenin-6-C-arabinopyranosyl-8-C-glucopyranoside (2),apigenin-7-O-β-D-glucuronide (3) and luteolin-7-O-β-D-glucuronide (4). Conclusion The fourcompounds were obtained from the genus Potentilla for the first time.
基金supported by the Fulbright Senior Scholar program granted to Dr A.Falodun to study at the School of Pharmacy,University of Mississippisupported by NIH,NIAID,Division of AIDS.Grant No.Al 27094(antifungal)+1 种基金the USDA Agricultural Research Service Specific Cooperative Agreement No.58-6408-1-603(antibacterial)TETFUND/DESS/RP/UNIV/BENIN/VOL.111 2013 and URPC VC.23
文摘Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.Methods:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses lo obtain three known metabolites,microcyclic lathyrane dilerpenoids(1-3).Structures were confirmed by comparison of 1D and 2D spectral data with literature.Results:The three compounds exhibited inhibition of antileishmanial,antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC_(50)of 82 and 8.7 μg/ml,respectively.Conclusions:The research lends support to the ethnomedicinal use of the plant in combating microbial infections,leishmaniasis and malarial infections.
文摘Biebersteinia multifida DC. has been used for the purpose of development of physical strength in iranian folk medicine. In the present study, we investigated the effect of Biebersteinia multifida DC. root extract on performance of the Forced Swimming Test (FST), and on blood biochemical parameters related to fatigue: Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), Glucose (Glc), and Total Protein (TP). Biebersteinia multifida DC. root extract was orally administered to mice at the doses 4, 7 and 10 mg/kg continuously once per day for 1 and 7 days using a feeding atraumatic needle. After 7 days, on FST the immobility time was decreased in the treated-groups at the doses 4 and 7 mg/kg, but after 1 day, only the immobility time of the treated- group at the dose of 4 mg/kg was decreased significantly. In addition, the content of Glc and TP in the blood serum was significantly increased in the groups receiving 4 and 7 mg/kg of Biebersteinia multifida DC. root extract for 7 days and LDH was decreased significantly. However, the levels of BUN and CK did not show a significant change. The results predict a potential benefit of Biebersteinia multifida DC. root extract as an anti-fatigue treatment and for improving physical stamina.
文摘Introduction: Jatropha multifida Lin was a plant of traditional Beninese medicine used as an antibiotic. This study aimed to evaluate the antibacterial activity and the toxicity of the sap and the aqueous extract of Jatropha multifida leaves. Methods: Phytochemical screening of Jatropha multifida leaves was carried out. The extract was obtained by maceration. The antimicrobial activity of sap and leaves was evaluated on the five strains of hospital germs. Acute oral toxicity by forced gavage in a single dose of 2000 mg/kg body weight was performed on female Wistar rats. Biochemical and hematological parameters were determined. Results: The presence of flavonoids, tannins, alkaloids, anthocyanins, mucilages, leuco-anthocyanins and saponosides was noted in the leaves of Jatropha multifida. The aqueous extracts of the leaves inhibited two strains of Staphylococcus aureus out of three, while the sap of Jatropha multifida was 100% bactericidal against the strains of Staphylococcus aureus and Streptococcus D. The sap and aqueous leaf extract were not bactericidal on strains of Escherichia coli, Klebsiella oxytoca and Pseudomonas aeruginosa. For the toxicity, there was no death of rats and the aqueous extract of the leaves did not significantly vary the weight of the rats, the creatinine, the ALAT transaminase, the hemoglobin level, the number of white blood cells and blood platelets. Conclusion: The sap of Jatropha multifida exerted a more effective antibacterial activity than the aqueous extract of its leaves. The leaves were not acutely toxic.
