Objectives:To assess the effects of a wearable-sensorassisted multicomponent exercise program on physical fitness,cognition and quality of life in a practical setting involving frail older adults.Methods:Frail older a...Objectives:To assess the effects of a wearable-sensorassisted multicomponent exercise program on physical fitness,cognition and quality of life in a practical setting involving frail older adults.Methods:Frail older adults(n=130)were randomly divided into a control(CG,n=68)group and an exercise group(EG,n=62)in a 12-week intervention,which included stride gait training with wearable sensors;aerobic exercise;and resistance,flexibility,balance,and cognitive training.Primary outcomes(physical fitness)were evaluated via the SPPB and SFT.Secondary outcomes(cognitive ability,quality of life and frailty)were evaluated via the MoCA-BC,SF-36 and Fried frailty criteria,respectively.Results:After the 12-week intervention,the EG demonstrated significant improvements(p<0.05)vs.the CG in gait speed(β_(3)=0.424,coefficient of interaction effect between group and time from the generalized linear mixed model),chair stand(β_(3)=0.501)and total score(β_(3)=65.466)of SPPB and all SFT components including 6MWT(walked distance,β_(3)=1.098;walking speed,β_(3)=0.105;stride length,β_(3)=0.041),back scratch(β_(3)=4.926),chair sit and reach(β_(3)=3.762),30s arm curl(β_(3)=6.124),30s sit-to-stand(β_(3)=3.04),and TUG(β_(3)=−6.712).The MoCA-BC total,verbal fluency and delayed recall scores;the physical function,general health,vitality,and mental health scores of the SF-36;and the frailty phenotype in the EG were significantly improved compared with those of the CG.Conclusions:The progressive wearable-sensor-assisted multicomponent exercise program designed in this study enhanced physical fitness,cognitive ability and quality of life and slowed down the progression of frailty in frail older adults,supporting its potential as a feasible communitybased health intervention.展开更多
Demographic aging is one of the most serious challenges facing our society.Although we live longer,we do not live better because it is considered that approximately 16–20%of our life is spent in late-life morbidity.O...Demographic aging is one of the most serious challenges facing our society.Although we live longer,we do not live better because it is considered that approximately 16–20%of our life is spent in late-life morbidity.Older people have the greatest risk of developing frailty increasing the risk of presenting various adverse health events such as low quality of life,disability,hospitalization and even death.Frail men and women over 65 years old have lower muscle quality and muscle mass and higher percentage of body fat than non-frail people of the same age.In this review we will address the main physiological changes in the muscular and nervous system associated to aging.More specifically we will review the changes in muscle mass,quality,and strength relating them with the decrease in capillarization and muscular oxidative capacity as well as with the alterations in protein synthesis in the muscle with aging.The last section of the manuscript will be devoted to the animal models of frailty and the indexes developed to measure frailty in these models.We will finally address the importance of exercise training as an intervention to delay or even reverse frailty.展开更多
基金supported by the project of Guangzhou Sports Science and Technology Collaborative Innovation Center(No.SL2022B04J00034)National Key Research and Development Program of China(No.2020YFC2002900)。
文摘Objectives:To assess the effects of a wearable-sensorassisted multicomponent exercise program on physical fitness,cognition and quality of life in a practical setting involving frail older adults.Methods:Frail older adults(n=130)were randomly divided into a control(CG,n=68)group and an exercise group(EG,n=62)in a 12-week intervention,which included stride gait training with wearable sensors;aerobic exercise;and resistance,flexibility,balance,and cognitive training.Primary outcomes(physical fitness)were evaluated via the SPPB and SFT.Secondary outcomes(cognitive ability,quality of life and frailty)were evaluated via the MoCA-BC,SF-36 and Fried frailty criteria,respectively.Results:After the 12-week intervention,the EG demonstrated significant improvements(p<0.05)vs.the CG in gait speed(β_(3)=0.424,coefficient of interaction effect between group and time from the generalized linear mixed model),chair stand(β_(3)=0.501)and total score(β_(3)=65.466)of SPPB and all SFT components including 6MWT(walked distance,β_(3)=1.098;walking speed,β_(3)=0.105;stride length,β_(3)=0.041),back scratch(β_(3)=4.926),chair sit and reach(β_(3)=3.762),30s arm curl(β_(3)=6.124),30s sit-to-stand(β_(3)=3.04),and TUG(β_(3)=−6.712).The MoCA-BC total,verbal fluency and delayed recall scores;the physical function,general health,vitality,and mental health scores of the SF-36;and the frailty phenotype in the EG were significantly improved compared with those of the CG.Conclusions:The progressive wearable-sensor-assisted multicomponent exercise program designed in this study enhanced physical fitness,cognitive ability and quality of life and slowed down the progression of frailty in frail older adults,supporting its potential as a feasible communitybased health intervention.
基金supported by the following grants:Instituto de Salud Carlos III and co-funded by FEDER[grant number PIE15/00013]SAF2016-75508-R from the Spanish Ministry of Education and Science(MEC),CB16/10/00435(CIBERFES),PROMETEOII2014/056 from“Conselleria,de Sanitat de la Generalitat Valenciana(GV/2018/118)EU Funded CM1001 and FRAILOMIC-HEALTH.2012.2.1.1-2,ADVANTAGE-724099 Join Action(HP-JA)3rd EU Health Programme and DIALBFRAIL-LATAM(825546 H2020-SC1-BHC).A.S-P was funded with a FPU grant from the Spanish MECD.
文摘Demographic aging is one of the most serious challenges facing our society.Although we live longer,we do not live better because it is considered that approximately 16–20%of our life is spent in late-life morbidity.Older people have the greatest risk of developing frailty increasing the risk of presenting various adverse health events such as low quality of life,disability,hospitalization and even death.Frail men and women over 65 years old have lower muscle quality and muscle mass and higher percentage of body fat than non-frail people of the same age.In this review we will address the main physiological changes in the muscular and nervous system associated to aging.More specifically we will review the changes in muscle mass,quality,and strength relating them with the decrease in capillarization and muscular oxidative capacity as well as with the alterations in protein synthesis in the muscle with aging.The last section of the manuscript will be devoted to the animal models of frailty and the indexes developed to measure frailty in these models.We will finally address the importance of exercise training as an intervention to delay or even reverse frailty.
