Drug repurposing offers a promising alternative to traditional drug development and significantly re-duces costs and timelines by identifying new therapeutic uses for existing drugs.However,the current approaches ofte...Drug repurposing offers a promising alternative to traditional drug development and significantly re-duces costs and timelines by identifying new therapeutic uses for existing drugs.However,the current approaches often rely on limited data sources and simplistic hypotheses,which restrict their ability to capture the multi-faceted nature of biological systems.This study introduces adaptive multi-view learning(AMVL),a novel methodology that integrates chemical-induced transcriptional profiles(CTPs),knowledge graph(KG)embeddings,and large language model(LLM)representations,to enhance drug repurposing predictions.AMVL incorporates an innovative similarity matrix expansion strategy and leverages multi-view learning(MVL),matrix factorization,and ensemble optimization techniques to integrate heterogeneous multi-source data.Comprehensive evaluations on benchmark datasets(Fdata-set,Cdataset,and Ydataset)and the large-scale iDrug dataset demonstrate that AMVL outperforms state-of-the-art(SOTA)methods,achieving superior accuracy in predicting drug-disease associations across multiple metrics.Literature-based validation further confirmed the model's predictive capabilities,with seven out of the top ten predictions corroborated by post-2011 evidence.To promote transparency and reproducibility,all data and codes used in this study were open-sourced,providing resources for pro-cessing CTPs,KG,and LLM-based similarity calculations,along with the complete AMVL algorithm and benchmarking procedures.By unifying diverse data modalities,AMVL offers a robust and scalable so-lution for accelerating drug discovery,fostering advancements in translational medicine and integrating multi-omics data.We aim to inspire further innovations in multi-source data integration and support the development of more precise and efficient strategies for advancing drug discovery and translational medicine.展开更多
Multi-view learning is an emerging field that aims to enhance learning performance by leveraging multiple views or sources of data across various domains.By integrating information from diverse perspectives,multi-view...Multi-view learning is an emerging field that aims to enhance learning performance by leveraging multiple views or sources of data across various domains.By integrating information from diverse perspectives,multi-view learning methods effectively enhance accuracy,robustness,and generalization capabilities.The existing research on multi-view learning can be broadly categorized into four groups in the survey based on the tasks it encompasses,namely multi-view classification approaches,multi-view semi-supervised classification approaches,multi-view clustering approaches,and multi-view semi-supervised clustering approaches.Despite its potential advantages,multi-view learning poses several challenges,including view inconsistency,view complementarity,optimal view fusion,the curse of dimensionality,scalability,limited labels,and generalization across domains.Nevertheless,these challenges have not discouraged researchers from exploring the potential of multiview learning.It continues to be an active and promising research area,capable of effectively addressing complex realworld problems.展开更多
The interactions between drugs and microbes affecting microbial abundance can lead to various diseases or reduce the effectiveness of pharmaceutical treatments.Traditional Microbe-Drug Association(MDA)determination th...The interactions between drugs and microbes affecting microbial abundance can lead to various diseases or reduce the effectiveness of pharmaceutical treatments.Traditional Microbe-Drug Association(MDA)determination through biological assays is time-consuming and costly.With the accumulation of MDA data,computational methods have become a promising approach to infer potential MDAs.Although existing methods focus on predicting whether a drug interacts with a microbe,they can rarely infer whether a drug promotes or inhibits the abundance of a given microbe.Moreover,the extreme imbalance among abundance-promoted,abundance-inhibited,and non-impacted cases remains a challenge for computational prediction methods.To address these issues,we propose a framework for predicting the imbalanced Impact of Drugs on Microbial Abundance by leveraging Multi-view Learning and Data Augmentation,named IDMA-MLDA.IDMA-MLDA employs a novel method of transforming a bipartite graph into a hypergraph,uses hypergraph convolutions to capture high-order vertex neighborhoods(macro-view),and employs graph neural networks to learn individual features of drugs and microbes(micro-view).It integrates features from both macro-view and micro-view to obtain more comprehensive representations,incorporates a data augmentation module to handle class imbalance,and uses a multilayer perceptron to predict the impact of drugs on microbial abundance.We demonstrate the superiority of IDMA-MLDA through comparisons with six baseline methods,and ablation studies affirm the contributions of each key module in IDMA-MLDA’s prediction.Furthermore,a comprehensive literature review verifies the abundance types of twelve MDAs predicted by IDMA-MLDA.展开更多
The accurate prediction of drug absorption,distribution,metabolism,excretion,and toxicity(ADMET)properties represents a crucial step in early drug development for reducing failure risk.Current deep learning approaches...The accurate prediction of drug absorption,distribution,metabolism,excretion,and toxicity(ADMET)properties represents a crucial step in early drug development for reducing failure risk.Current deep learning approaches face challenges with data sparsity and information loss due to single-molecule representation limitations and isolated predictive tasks.This research proposes molecular properties prediction with parallel-view and collaborative learning(MolP-PC),a multi-view fusion and multi-task deep learning framework that integrates 1D molecular fingerprints(MFs),2D molecular graphs,and 3D geometric representations,incorporating an attention-gated fusion mechanism and multi-task adaptive learning strategy for precise ADMET property predictions.Experimental results demonstrate that MolP-PC achieves optimal performance in 27 of 54 tasks,with its multi-task learning(MTL)mechanism significantly enhancing predictive performance on small-scale datasets and surpassing single-task models in 41 of 54 tasks.Additional ablation studies and interpretability analyses confirm the significance of multi-view fusion in capturing multi-dimensional molecular information and enhancing model generalization.A case study examining the anticancer compound Oroxylin A demonstrates MolP-PC’s effective generalization in predicting key pharmacokinetic parameters such as half-life(T0.5)and clearance(CL),indicating its practical utility in drug modeling.However,the model exhibits a tendency to underestimate volume of distribution(VD),indicating potential for improvement in analyzing compounds with high tissue distribution.This study presents an efficient and interpretable approach for ADMET property prediction,establishing a novel framework for molecular optimization and risk assessment in drug development.展开更多
BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning ofte...BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.展开更多
Background:Stomach cancer(SC)is one of the most lethal malignancies worldwide due to late-stage diagnosis and limited treatment.The transcriptomic,epigenomic,and proteomic,etc.,omics datasets generated by high-through...Background:Stomach cancer(SC)is one of the most lethal malignancies worldwide due to late-stage diagnosis and limited treatment.The transcriptomic,epigenomic,and proteomic,etc.,omics datasets generated by high-throughput sequencing technology have become prominent in biomedical research,and they reveal molecular aspects of cancer diagnosis and therapy.Despite the development of advanced sequencing technology,the presence of high-dimensionality in multi-omics data makes it challenging to interpret the data.Methods:In this study,we introduce RankXLAN,an explainable ensemble-based multi-omics framework that integrates feature selection(FS),ensemble learning,bioinformatics,and in-silico validation for robust biomarker detection,potential therapeutic drug-repurposing candidates’identification,and classification of SC.To enhance the interpretability of the model,we incorporated explainable artificial intelligence(SHapley Additive exPlanations analysis),as well as accuracy,precision,F1-score,recall,cross-validation,specificity,likelihood ratio(LR)+,LR−,and Youden index results.Results:The experimental results showed that the top four FS algorithms achieved improved results when applied to the ensemble learning classification model.The proposed ensemble model produced an area under the curve(AUC)score of 0.994 for gene expression,0.97 for methylation,and 0.96 for miRNA expression data.Through the integration of bioinformatics and ML approach of the transcriptomic and epigenomic multi-omics dataset,we identified potential marker genes,namely,UBE2D2,HPCAL4,IGHA1,DPT,and FN3K.In-silico molecular docking revealed a strong binding affinity between ANKRD13C and the FDA-approved drug Everolimus(binding affinity−10.1 kcal/mol),identifying ANKRD13C as a potential therapeutic drug-repurposing target for SC.Conclusion:The proposed framework RankXLAN outperforms other existing frameworks for serum biomarker identification,therapeutic target identification,and SC classification with multi-omics datasets.展开更多
Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human-machine interfaces for real-time health monitoring,clinical diagnosis,and robotic applications.Nevertheless,...Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human-machine interfaces for real-time health monitoring,clinical diagnosis,and robotic applications.Nevertheless,it remains a critical challenge to simultaneously achieve desirable mechanical and electrical performance along with biocompatibility,adhesion,self-healing,and environmental robustness with excellent sensing metrics.Herein,we report a multifunctional,anti-freezing,selfadhesive,and self-healable organogel pressure sensor composed of cobalt nanoparticle encapsulated nitrogen-doped carbon nanotubes(CoN CNT)embedded in a polyvinyl alcohol-gelatin(PVA/GLE)matrix.Fabricated using a binary solvent system of water and ethylene glycol(EG),the CoN CNT/PVA/GLE organogel exhibits excellent flexibility,biocompatibility,and temperature tolerance with remarkable environmental stability.Electrochemical impedance spectroscopy confirms near-stable performance across a broad humidity range(40%-95%RH).Freeze-tolerant conductivity under sub-zero conditions(-20℃)is attributed to the synergistic role of CoN CNT and EG,preserving mobility and network integrity.The Co N CNT/PVA/GLE organogel sensor exhibits high sensitivity of 5.75 k Pa^(-1)in the detection range from 0 to 20 k Pa,ideal for subtle biomechanical motion detection.A smart human-machine interface for English letter recognition using deep learning achieved 98%accuracy.The organogel sensor utility was extended to detect human gestures like finger bending,wrist motion,and throat vibration during speech.展开更多
Gastrointestinal(GI)cancers remain a leading cause of cancer-related morbidity and mortality worldwide.Artificial intelligence(AI),particularly machine learning and deep learning(DL),has shown promise in enhancing can...Gastrointestinal(GI)cancers remain a leading cause of cancer-related morbidity and mortality worldwide.Artificial intelligence(AI),particularly machine learning and deep learning(DL),has shown promise in enhancing cancer detection,diagnosis,and prognostication.A narrative review of literature published from January 2015 to march 2025 was conducted using PubMed,Web of Science,and Scopus.Search terms included"gastrointestinal cancer","artificial intelligence","machine learning","deep learning","radiomics","multimodal detection"and"predictive modeling".Studies were included if they focused on clinically relevant AI applications in GI oncology.AI algorithms for GI cancer detection have achieved high performance across imaging modalities,with endoscopic DL systems reporting accuracies of 85%-97%for polyp detection and segmentation.Radiomics-based models have predicted molecular biomarkers such as programmed cell death ligand 2 expression with area under the curves up to 0.92.Large language models applied to radiology reports demonstrated diagnostic accuracy comparable to junior radiologists(78.9%vs 80.0%),though without incremental value when combined with human interpretation.Multimodal AI approaches integrating imaging,pathology,and clinical data show emerging potential for precision oncology.AI in GI oncology has reached clinically relevant accuracy levels in multiple diagnostic tasks,with multimodal approaches and predictive biomarker modeling offering new opportunities for personalized care.However,broader validation,integration into clinical workflows,and attention to ethical,legal,and social implications remain critical for widespread adoption.展开更多
While reinforcement learning-based underwater acoustic adaptive modulation shows promise for enabling environment-adaptive communication as supported by extensive simulation-based research,its practical performance re...While reinforcement learning-based underwater acoustic adaptive modulation shows promise for enabling environment-adaptive communication as supported by extensive simulation-based research,its practical performance remains underexplored in field investigations.To evaluate the practical applicability of this emerging technique in adverse shallow sea channels,a field experiment was conducted using three communication modes:orthogonal frequency division multiplexing(OFDM),M-ary frequency-shift keying(MFSK),and direct sequence spread spectrum(DSSS)for reinforcement learning-driven adaptive modulation.Specifically,a Q-learning method is used to select the optimal modulation mode according to the channel quality quantified by signal-to-noise ratio,multipath spread length,and Doppler frequency offset.Experimental results demonstrate that the reinforcement learning-based adaptive modulation scheme outperformed fixed threshold detection in terms of total throughput and average bit error rate,surpassing conventional adaptive modulation strategies.展开更多
Automated classification of gas flow states in blast furnaces using top-camera imagery typically demands a large volume of labeled data,whose manual annotation is both labor-intensive and cost-prohibitive.To mitigate ...Automated classification of gas flow states in blast furnaces using top-camera imagery typically demands a large volume of labeled data,whose manual annotation is both labor-intensive and cost-prohibitive.To mitigate this challenge,we present an enhanced semi-supervised learning approach based on the Mean Teacher framework,incorporating a novel feature loss module to maximize classification performance with limited labeled samples.The model studies show that the proposed model surpasses both the baseline Mean Teacher model and fully supervised method in accuracy.Specifically,for datasets with 20%,30%,and 40%label ratios,using a single training iteration,the model yields accuracies of 78.61%,82.21%,and 85.2%,respectively,while multiple-cycle training iterations achieves 82.09%,81.97%,and 81.59%,respectively.Furthermore,scenario-specific training schemes are introduced to support diverse deployment need.These findings highlight the potential of the proposed technique in minimizing labeling requirements and advancing intelligent blast furnace diagnostics.展开更多
Deep learning-based methods have become alternatives to traditional numerical weather prediction systems,offering faster computation and the ability to utilize large historical datasets.However,the application of deep...Deep learning-based methods have become alternatives to traditional numerical weather prediction systems,offering faster computation and the ability to utilize large historical datasets.However,the application of deep learning to medium-range regional weather forecasting with limited data remains a significant challenge.In this work,three key solutions are proposed:(1)motivated by the need to improve model performance in data-scarce regional forecasting scenarios,the authors innovatively apply semantic segmentation models,to better capture spatiotemporal features and improve prediction accuracy;(2)recognizing the challenge of overfitting and the inability of traditional noise-based data augmentation methods to effectively enhance model robustness,a novel learnable Gaussian noise mechanism is introduced that allows the model to adaptively optimize perturbations for different locations,ensuring more effective learning;and(3)to address the issue of error accumulation in autoregressive prediction,as well as the challenge of learning difficulty and the lack of intermediate data utilization in one-shot prediction,the authors propose a cascade prediction approach that effectively resolves these problems while significantly improving model forecasting performance.The method achieves a competitive result in The East China Regional AI Medium Range Weather Forecasting Competition.Ablation experiments further validate the effectiveness of each component,highlighting their contributions to enhancing prediction performance.展开更多
Underwater pipeline inspection plays a vital role in the proactive maintenance and management of critical marine infrastructure and subaquatic systems.However,the inspection of underwater pipelines presents a challeng...Underwater pipeline inspection plays a vital role in the proactive maintenance and management of critical marine infrastructure and subaquatic systems.However,the inspection of underwater pipelines presents a challenge due to factors such as light scattering,absorption,restricted visibility,and ambient noise.The advancement of deep learning has introduced powerful techniques for processing large amounts of unstructured and imperfect data collected from underwater environments.This study evaluated the efficacy of the You Only Look Once(YOLO)algorithm,a real-time object detection and localization model based on convolutional neural networks,in identifying and classifying various types of pipeline defects in underwater settings.YOLOv8,the latest evolution in the YOLO family,integrates advanced capabilities,such as anchor-free detection,a cross-stage partial network backbone for efficient feature extraction,and a feature pyramid network+path aggregation network neck for robust multi-scale object detection,which make it particularly well-suited for complex underwater environments.Due to the lack of suitable open-access datasets for underwater pipeline defects,a custom dataset was captured using a remotely operated vehicle in a controlled environment.This application has the following assets available for use.Extensive experimentation demonstrated that YOLOv8 X-Large consistently outperformed other models in terms of pipe defect detection and classification and achieved a strong balance between precision and recall in identifying pipeline cracks,rust,corners,defective welds,flanges,tapes,and holes.This research establishes the baseline performance of YOLOv8 for underwater defect detection and showcases its potential to enhance the reliability and efficiency of pipeline inspection tasks in challenging underwater environments.展开更多
Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the ...Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the authors present a machine learning-based risk prediction approach using routinely available clinical and laboratory parameters.Among the evaluated algorithms,a decision tree model demonstrated excellent discrimination,achieving an area under the curve of 0.951 in the validation set and notably identifying all true cases of delayed wound healing at the Youden index threshold.The inclusion of variables such as drainage duration,preoperative white blood cell and neutrophil counts,alongside age and sex,highlights the pragmatic appeal of the model for early postoperative monitoring.Nevertheless,several aspects warrant critical reflection,including the reliance on a postoperative variable(drainage duration),internal validation only,and certain reporting inconsistencies.This letter underscores both the promise and the limitations of adopting interpretable machine learning models in perioperative care.We advocate for transparent reporting,external validation,and careful consideration of clinically actionable timepoints before integration into practice.Ultimately,this work represents a valuable step toward precision risk stratification in gastric cancer surgery,and sets the stage for multicenter,prospective evaluations.展开更多
Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening pa...Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening particles also deteriorates the processability and it is of great importance to establish accurate processing maps to guide the thermomechanical processes to enhance the formability.In this study,we performed particle swarm optimization-based back propagation artificial neural network model to predict the high temperature flow behavior of 0.25wt%Al2O3 particle-reinforced Cu alloys,and compared the accuracy with that of derived by Arrhenius-type constitutive model and back propagation artificial neural network model.To train these models,we obtained the raw data by fabricating ODS Cu alloys using the internal oxidation and reduction method,and conducting systematic hot compression tests between 400 and800℃with strain rates of 10^(-2)-10 S^(-1).At last,processing maps for ODS Cu alloys were proposed by combining processing parameters,mechanical behavior,microstructure characterization,and the modeling results achieved a coefficient of determination higher than>99%.展开更多
An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction...An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction,was conducted to extract useful feature information and recognize and classify rock images using Tensor Flow-based convolutional neural network(CNN)and Py Qt5.A rock image dataset was established and separated into workouts,confirmation sets,and test sets.The framework was subsequently compiled and trained.The categorization approach was evaluated using image data from the validation and test datasets,and key metrics,such as accuracy,precision,and recall,were analyzed.Finally,the classification model conducted a probabilistic analysis of the measured data to determine the equivalent lithological type for each image.The experimental results indicated that the method combining deep learning,Tensor Flow-based CNN,and Py Qt5 to recognize and classify rock images has an accuracy rate of up to 98.8%,and can be successfully utilized for rock image recognition.The system can be extended to geological exploration,mine engineering,and other rock and mineral resource development to more efficiently and accurately recognize rock samples.Moreover,it can match them with the intelligent support design system to effectively improve the reliability and economy of the support scheme.The system can serve as a reference for supporting the design of other mining and underground space projects.展开更多
The rapid growth of biomedical data,particularly multi-omics data including genomes,transcriptomics,proteomics,metabolomics,and epigenomics,medical research and clinical decision-making confront both new opportunities...The rapid growth of biomedical data,particularly multi-omics data including genomes,transcriptomics,proteomics,metabolomics,and epigenomics,medical research and clinical decision-making confront both new opportunities and obstacles.The huge and diversified nature of these datasets cannot always be managed using traditional data analysis methods.As a consequence,deep learning has emerged as a strong tool for analysing numerous omics data due to its ability to handle complex and non-linear relationships.This paper explores the fundamental concepts of deep learning and how they are used in multi-omics medical data mining.We demonstrate how autoencoders,variational autoencoders,multimodal models,attention mechanisms,transformers,and graph neural networks enable pattern analysis and recognition across all omics data.Deep learning has been found to be effective in illness classification,biomarker identification,gene network learning,and therapeutic efficacy prediction.We also consider critical problems like as data quality,model explainability,whether findings can be repeated,and computational power requirements.We now consider future elements of combining omics with clinical and imaging data,explainable AI,federated learning,and real-time diagnostics.Overall,this study emphasises the need of collaborating across disciplines to advance deep learning-based multi-omics research for precision medicine and comprehending complicated disorders.展开更多
Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML...Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML)has emerged as a powerful data analysis tool,widely applied in the prediction,diagnosis,and mechanistic study of kidney transplant rejection.This mini-review systematically summarizes the recent applications of ML techniques in post-kidney transplant rejection,covering areas such as the construction of predictive models,identification of biomarkers,analysis of pathological images,assessment of immune cell infiltration,and formulation of personalized treatment strategies.By integrating multi-omics data and clinical information,ML has significantly enhanced the accuracy of early rejection diagnosis and the capability for prognostic evaluation,driving the development of precision medicine in the field of kidney transplantation.Furthermore,this article discusses the challenges faced in existing research and potential future directions,providing a theoretical basis and technical references for related studies.展开更多
With the enhancement of data collection capabilities,massive streaming data have been accumulated in numerous application scenarios.Specifically,the issue of classifying data streams based on mobile sensors can be for...With the enhancement of data collection capabilities,massive streaming data have been accumulated in numerous application scenarios.Specifically,the issue of classifying data streams based on mobile sensors can be formalized as a multi-task multi-view learning problem with a specific task comprising multiple views with shared features collected from multiple sensors.Existing incremental learning methods are often single-task single-view,which cannot learn shared representations between relevant tasks and views.An adaptive multi-task multi-view incremental learning framework for data stream classification called MTMVIS is proposed to address the above challenges,utilizing the idea of multi-task multi-view learning.Specifically,the attention mechanism is first used to align different sensor data of different views.In addition,MTMVIS uses adaptive Fisher regularization from the perspective of multi-task multi-view learning to overcome catastrophic forgetting in incremental learning.Results reveal that the proposed framework outperforms state-of-the-art methods based on the experiments on two different datasets with other baselines.展开更多
Label noise is often contained in the training data due to various human factors or measurement errors,which significantly causes a negative effect on classifiers.Despite many previous methods that have been proposed ...Label noise is often contained in the training data due to various human factors or measurement errors,which significantly causes a negative effect on classifiers.Despite many previous methods that have been proposed to learn robust classifiers,they are mainly based on the single-view feature.On the other hand,although existing multi-view classification methods benefit from the more comprehensive information,they rarely consider label noise.In this paper,we propose a novel label-noise robust classification model with multi-view learning to overcome these limitations.In the proposed model,not only the classifier learning but also the label-noise removal can benefit from the multi-view information.Specifically,we relax the label matrix of the basic multi-view least squares regression model,and develop a nonlinear transformation with a natural probabilistic approximation in the process of labels,which is conveniently optimized and beneficial to improve the discriminative ability of classifiers.Moreover,we preserve the intrinsic manifold structure of multi-view data on the relaxed label matrix,facilitating the process of label relaxation.For optimizing the proposed model with the nonlinear transformation,we derive a lemma about the partial derivation of the softmax related function,and develop an efficient alternating algorithm.Experimental evaluations on six real-world datasets confirm the advantages of the proposed method,compared to the related state-of-the-art methods.展开更多
Human action recognition is currently one of the most active research areas in computer vision. It has been widely used in many applications, such as intelligent surveillance, perceptual interface, and content-based v...Human action recognition is currently one of the most active research areas in computer vision. It has been widely used in many applications, such as intelligent surveillance, perceptual interface, and content-based video retrieval. However, some extrinsic factors are barriers for the development of action recognition; e.g., human actions may be observed from arbitrary camera viewpoints in realistic scene. Thus, view-invariant analysis becomes important for action recognition algorithms, and a number of researchers have paid much attention to this issue. In this paper, we present a multi-view learning approach to recognize human actions from different views. As most existing multi-view learning algorithms often suffer from the problem of lacking data adaptiveness in the nearest neighborhood graph construction procedure, a robust locally adaptive multi-view learning algorithm based on learning multiple local L 1-graphs is proposed. Moreover, an efficient iterative optimization method is proposed to solve the proposed objective function. Experiments on three public view-invariant action recognition datasets, i.e., ViHASi, IXMAS, and WVU, demonstrate data adaptiveness, effectiveness, and efficiency of our algorithm. More importantly, when the feature dimension is correctly selected （i.e., 〉60）, the proposed algorithm stably outperforms state-of-the-art counterparts and obtains about 6% improvement in recognition accuracy on the three datasets.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.:62101087)the China Postdoctoral Science Foundation(Grant No.:2021MD703942)+2 种基金the Chongqing Postdoctoral Research Project Special Funding,China(Grant No.:2021XM2016)the Science Foundation of Chongqing Municipal Commission of Education,China(Grant No.:KJQN202100642)the Chongqing Natural Science Foundation,China(Grant No.:cstc2021jcyj-msxmX0834).
文摘Drug repurposing offers a promising alternative to traditional drug development and significantly re-duces costs and timelines by identifying new therapeutic uses for existing drugs.However,the current approaches often rely on limited data sources and simplistic hypotheses,which restrict their ability to capture the multi-faceted nature of biological systems.This study introduces adaptive multi-view learning(AMVL),a novel methodology that integrates chemical-induced transcriptional profiles(CTPs),knowledge graph(KG)embeddings,and large language model(LLM)representations,to enhance drug repurposing predictions.AMVL incorporates an innovative similarity matrix expansion strategy and leverages multi-view learning(MVL),matrix factorization,and ensemble optimization techniques to integrate heterogeneous multi-source data.Comprehensive evaluations on benchmark datasets(Fdata-set,Cdataset,and Ydataset)and the large-scale iDrug dataset demonstrate that AMVL outperforms state-of-the-art(SOTA)methods,achieving superior accuracy in predicting drug-disease associations across multiple metrics.Literature-based validation further confirmed the model's predictive capabilities,with seven out of the top ten predictions corroborated by post-2011 evidence.To promote transparency and reproducibility,all data and codes used in this study were open-sourced,providing resources for pro-cessing CTPs,KG,and LLM-based similarity calculations,along with the complete AMVL algorithm and benchmarking procedures.By unifying diverse data modalities,AMVL offers a robust and scalable so-lution for accelerating drug discovery,fostering advancements in translational medicine and integrating multi-omics data.We aim to inspire further innovations in multi-source data integration and support the development of more precise and efficient strategies for advancing drug discovery and translational medicine.
基金supported in part by the Major Key Project of PCL,China(PCL2023AS7-1 and PCL2023A09)in part by the National Key R&D Program of China(2023YFA1011601)+1 种基金in part by the National Natural Science Foundation of China(Grant Nos.62106224 and U21A20478)in part by the Guangzhou Science and Technology Plan Project(2024A04J3749).
文摘Multi-view learning is an emerging field that aims to enhance learning performance by leveraging multiple views or sources of data across various domains.By integrating information from diverse perspectives,multi-view learning methods effectively enhance accuracy,robustness,and generalization capabilities.The existing research on multi-view learning can be broadly categorized into four groups in the survey based on the tasks it encompasses,namely multi-view classification approaches,multi-view semi-supervised classification approaches,multi-view clustering approaches,and multi-view semi-supervised clustering approaches.Despite its potential advantages,multi-view learning poses several challenges,including view inconsistency,view complementarity,optimal view fusion,the curse of dimensionality,scalability,limited labels,and generalization across domains.Nevertheless,these challenges have not discouraged researchers from exploring the potential of multiview learning.It continues to be an active and promising research area,capable of effectively addressing complex realworld problems.
基金supported by the National Natural Science Foundation of China(No.62372375)the Shaanxi Province Key R&D Program(No.2023-YBSF-114)the CAAI-Huawei MindSpore Open Fund(No.CAAIXSJLJJ-2022-035A).
文摘The interactions between drugs and microbes affecting microbial abundance can lead to various diseases or reduce the effectiveness of pharmaceutical treatments.Traditional Microbe-Drug Association(MDA)determination through biological assays is time-consuming and costly.With the accumulation of MDA data,computational methods have become a promising approach to infer potential MDAs.Although existing methods focus on predicting whether a drug interacts with a microbe,they can rarely infer whether a drug promotes or inhibits the abundance of a given microbe.Moreover,the extreme imbalance among abundance-promoted,abundance-inhibited,and non-impacted cases remains a challenge for computational prediction methods.To address these issues,we propose a framework for predicting the imbalanced Impact of Drugs on Microbial Abundance by leveraging Multi-view Learning and Data Augmentation,named IDMA-MLDA.IDMA-MLDA employs a novel method of transforming a bipartite graph into a hypergraph,uses hypergraph convolutions to capture high-order vertex neighborhoods(macro-view),and employs graph neural networks to learn individual features of drugs and microbes(micro-view).It integrates features from both macro-view and micro-view to obtain more comprehensive representations,incorporates a data augmentation module to handle class imbalance,and uses a multilayer perceptron to predict the impact of drugs on microbial abundance.We demonstrate the superiority of IDMA-MLDA through comparisons with six baseline methods,and ablation studies affirm the contributions of each key module in IDMA-MLDA’s prediction.Furthermore,a comprehensive literature review verifies the abundance types of twelve MDAs predicted by IDMA-MLDA.
基金supported by the research on key technologies for monitoring and identifying drug abuse of anesthetic drugs and psychotropic drugs,and intervention for addiction(No.2023YFC3304200)the program of a study on the diagnosis of addiction to synthetic cannabinoids and methods of assessing the risk of abuse(No.2022YFC3300905)+1 种基金the program of Ab initio design and generation of AI models for small molecule ligands based on target structures(No.2022PE0AC03)ZHIJIANG LAB.
文摘The accurate prediction of drug absorption,distribution,metabolism,excretion,and toxicity(ADMET)properties represents a crucial step in early drug development for reducing failure risk.Current deep learning approaches face challenges with data sparsity and information loss due to single-molecule representation limitations and isolated predictive tasks.This research proposes molecular properties prediction with parallel-view and collaborative learning(MolP-PC),a multi-view fusion and multi-task deep learning framework that integrates 1D molecular fingerprints(MFs),2D molecular graphs,and 3D geometric representations,incorporating an attention-gated fusion mechanism and multi-task adaptive learning strategy for precise ADMET property predictions.Experimental results demonstrate that MolP-PC achieves optimal performance in 27 of 54 tasks,with its multi-task learning(MTL)mechanism significantly enhancing predictive performance on small-scale datasets and surpassing single-task models in 41 of 54 tasks.Additional ablation studies and interpretability analyses confirm the significance of multi-view fusion in capturing multi-dimensional molecular information and enhancing model generalization.A case study examining the anticancer compound Oroxylin A demonstrates MolP-PC’s effective generalization in predicting key pharmacokinetic parameters such as half-life(T0.5)and clearance(CL),indicating its practical utility in drug modeling.However,the model exhibits a tendency to underestimate volume of distribution(VD),indicating potential for improvement in analyzing compounds with high tissue distribution.This study presents an efficient and interpretable approach for ADMET property prediction,establishing a novel framework for molecular optimization and risk assessment in drug development.
基金Supported by Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau),No.2023MSXM060.
文摘BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.
基金the Deanship of Research and Graduate Studies at King Khalid University,KSA,for funding this work through the Large Research Project under grant number RGP2/164/46.
文摘Background:Stomach cancer(SC)is one of the most lethal malignancies worldwide due to late-stage diagnosis and limited treatment.The transcriptomic,epigenomic,and proteomic,etc.,omics datasets generated by high-throughput sequencing technology have become prominent in biomedical research,and they reveal molecular aspects of cancer diagnosis and therapy.Despite the development of advanced sequencing technology,the presence of high-dimensionality in multi-omics data makes it challenging to interpret the data.Methods:In this study,we introduce RankXLAN,an explainable ensemble-based multi-omics framework that integrates feature selection(FS),ensemble learning,bioinformatics,and in-silico validation for robust biomarker detection,potential therapeutic drug-repurposing candidates’identification,and classification of SC.To enhance the interpretability of the model,we incorporated explainable artificial intelligence(SHapley Additive exPlanations analysis),as well as accuracy,precision,F1-score,recall,cross-validation,specificity,likelihood ratio(LR)+,LR−,and Youden index results.Results:The experimental results showed that the top four FS algorithms achieved improved results when applied to the ensemble learning classification model.The proposed ensemble model produced an area under the curve(AUC)score of 0.994 for gene expression,0.97 for methylation,and 0.96 for miRNA expression data.Through the integration of bioinformatics and ML approach of the transcriptomic and epigenomic multi-omics dataset,we identified potential marker genes,namely,UBE2D2,HPCAL4,IGHA1,DPT,and FN3K.In-silico molecular docking revealed a strong binding affinity between ANKRD13C and the FDA-approved drug Everolimus(binding affinity−10.1 kcal/mol),identifying ANKRD13C as a potential therapeutic drug-repurposing target for SC.Conclusion:The proposed framework RankXLAN outperforms other existing frameworks for serum biomarker identification,therapeutic target identification,and SC classification with multi-omics datasets.
基金supported by the Basic Science Research Program(2023R1A2C3004336,RS-202300243807)&Regional Leading Research Center(RS-202400405278)through the National Research Foundation of Korea(NRF)grant funded by the Korea Government(MSIT)。
文摘Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human-machine interfaces for real-time health monitoring,clinical diagnosis,and robotic applications.Nevertheless,it remains a critical challenge to simultaneously achieve desirable mechanical and electrical performance along with biocompatibility,adhesion,self-healing,and environmental robustness with excellent sensing metrics.Herein,we report a multifunctional,anti-freezing,selfadhesive,and self-healable organogel pressure sensor composed of cobalt nanoparticle encapsulated nitrogen-doped carbon nanotubes(CoN CNT)embedded in a polyvinyl alcohol-gelatin(PVA/GLE)matrix.Fabricated using a binary solvent system of water and ethylene glycol(EG),the CoN CNT/PVA/GLE organogel exhibits excellent flexibility,biocompatibility,and temperature tolerance with remarkable environmental stability.Electrochemical impedance spectroscopy confirms near-stable performance across a broad humidity range(40%-95%RH).Freeze-tolerant conductivity under sub-zero conditions(-20℃)is attributed to the synergistic role of CoN CNT and EG,preserving mobility and network integrity.The Co N CNT/PVA/GLE organogel sensor exhibits high sensitivity of 5.75 k Pa^(-1)in the detection range from 0 to 20 k Pa,ideal for subtle biomechanical motion detection.A smart human-machine interface for English letter recognition using deep learning achieved 98%accuracy.The organogel sensor utility was extended to detect human gestures like finger bending,wrist motion,and throat vibration during speech.
文摘Gastrointestinal(GI)cancers remain a leading cause of cancer-related morbidity and mortality worldwide.Artificial intelligence(AI),particularly machine learning and deep learning(DL),has shown promise in enhancing cancer detection,diagnosis,and prognostication.A narrative review of literature published from January 2015 to march 2025 was conducted using PubMed,Web of Science,and Scopus.Search terms included"gastrointestinal cancer","artificial intelligence","machine learning","deep learning","radiomics","multimodal detection"and"predictive modeling".Studies were included if they focused on clinically relevant AI applications in GI oncology.AI algorithms for GI cancer detection have achieved high performance across imaging modalities,with endoscopic DL systems reporting accuracies of 85%-97%for polyp detection and segmentation.Radiomics-based models have predicted molecular biomarkers such as programmed cell death ligand 2 expression with area under the curves up to 0.92.Large language models applied to radiology reports demonstrated diagnostic accuracy comparable to junior radiologists(78.9%vs 80.0%),though without incremental value when combined with human interpretation.Multimodal AI approaches integrating imaging,pathology,and clinical data show emerging potential for precision oncology.AI in GI oncology has reached clinically relevant accuracy levels in multiple diagnostic tasks,with multimodal approaches and predictive biomarker modeling offering new opportunities for personalized care.However,broader validation,integration into clinical workflows,and attention to ethical,legal,and social implications remain critical for widespread adoption.
基金funding from the National Key Research and Development Program of China(No.2018YFE0110000)the National Natural Science Foundation of China(No.11274259,No.11574258)the Science and Technology Commission Foundation of Shanghai(21DZ1205500)in support of the present research.
文摘While reinforcement learning-based underwater acoustic adaptive modulation shows promise for enabling environment-adaptive communication as supported by extensive simulation-based research,its practical performance remains underexplored in field investigations.To evaluate the practical applicability of this emerging technique in adverse shallow sea channels,a field experiment was conducted using three communication modes:orthogonal frequency division multiplexing(OFDM),M-ary frequency-shift keying(MFSK),and direct sequence spread spectrum(DSSS)for reinforcement learning-driven adaptive modulation.Specifically,a Q-learning method is used to select the optimal modulation mode according to the channel quality quantified by signal-to-noise ratio,multipath spread length,and Doppler frequency offset.Experimental results demonstrate that the reinforcement learning-based adaptive modulation scheme outperformed fixed threshold detection in terms of total throughput and average bit error rate,surpassing conventional adaptive modulation strategies.
基金financial support provided by the Natural Science Foundation of Hebei Province,China(No.E2024105036)the Tangshan Talent Funding Project,China(Nos.B202302007 and A2021110015)+1 种基金the National Natural Science Foundation of China(No.52264042)the Australian Research Council(No.IH230100010)。
文摘Automated classification of gas flow states in blast furnaces using top-camera imagery typically demands a large volume of labeled data,whose manual annotation is both labor-intensive and cost-prohibitive.To mitigate this challenge,we present an enhanced semi-supervised learning approach based on the Mean Teacher framework,incorporating a novel feature loss module to maximize classification performance with limited labeled samples.The model studies show that the proposed model surpasses both the baseline Mean Teacher model and fully supervised method in accuracy.Specifically,for datasets with 20%,30%,and 40%label ratios,using a single training iteration,the model yields accuracies of 78.61%,82.21%,and 85.2%,respectively,while multiple-cycle training iterations achieves 82.09%,81.97%,and 81.59%,respectively.Furthermore,scenario-specific training schemes are introduced to support diverse deployment need.These findings highlight the potential of the proposed technique in minimizing labeling requirements and advancing intelligent blast furnace diagnostics.
基金supported by the National Natural Science Foundation of China[grant number 62376217]the Young Elite Scientists Sponsorship Program by CAST[grant number 2023QNRC001]the Joint Research Project for Meteorological Capacity Improvement[grant number 24NLTSZ003]。
文摘Deep learning-based methods have become alternatives to traditional numerical weather prediction systems,offering faster computation and the ability to utilize large historical datasets.However,the application of deep learning to medium-range regional weather forecasting with limited data remains a significant challenge.In this work,three key solutions are proposed:(1)motivated by the need to improve model performance in data-scarce regional forecasting scenarios,the authors innovatively apply semantic segmentation models,to better capture spatiotemporal features and improve prediction accuracy;(2)recognizing the challenge of overfitting and the inability of traditional noise-based data augmentation methods to effectively enhance model robustness,a novel learnable Gaussian noise mechanism is introduced that allows the model to adaptively optimize perturbations for different locations,ensuring more effective learning;and(3)to address the issue of error accumulation in autoregressive prediction,as well as the challenge of learning difficulty and the lack of intermediate data utilization in one-shot prediction,the authors propose a cascade prediction approach that effectively resolves these problems while significantly improving model forecasting performance.The method achieves a competitive result in The East China Regional AI Medium Range Weather Forecasting Competition.Ablation experiments further validate the effectiveness of each component,highlighting their contributions to enhancing prediction performance.
文摘Underwater pipeline inspection plays a vital role in the proactive maintenance and management of critical marine infrastructure and subaquatic systems.However,the inspection of underwater pipelines presents a challenge due to factors such as light scattering,absorption,restricted visibility,and ambient noise.The advancement of deep learning has introduced powerful techniques for processing large amounts of unstructured and imperfect data collected from underwater environments.This study evaluated the efficacy of the You Only Look Once(YOLO)algorithm,a real-time object detection and localization model based on convolutional neural networks,in identifying and classifying various types of pipeline defects in underwater settings.YOLOv8,the latest evolution in the YOLO family,integrates advanced capabilities,such as anchor-free detection,a cross-stage partial network backbone for efficient feature extraction,and a feature pyramid network+path aggregation network neck for robust multi-scale object detection,which make it particularly well-suited for complex underwater environments.Due to the lack of suitable open-access datasets for underwater pipeline defects,a custom dataset was captured using a remotely operated vehicle in a controlled environment.This application has the following assets available for use.Extensive experimentation demonstrated that YOLOv8 X-Large consistently outperformed other models in terms of pipe defect detection and classification and achieved a strong balance between precision and recall in identifying pipeline cracks,rust,corners,defective welds,flanges,tapes,and holes.This research establishes the baseline performance of YOLOv8 for underwater defect detection and showcases its potential to enhance the reliability and efficiency of pipeline inspection tasks in challenging underwater environments.
文摘Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the authors present a machine learning-based risk prediction approach using routinely available clinical and laboratory parameters.Among the evaluated algorithms,a decision tree model demonstrated excellent discrimination,achieving an area under the curve of 0.951 in the validation set and notably identifying all true cases of delayed wound healing at the Youden index threshold.The inclusion of variables such as drainage duration,preoperative white blood cell and neutrophil counts,alongside age and sex,highlights the pragmatic appeal of the model for early postoperative monitoring.Nevertheless,several aspects warrant critical reflection,including the reliance on a postoperative variable(drainage duration),internal validation only,and certain reporting inconsistencies.This letter underscores both the promise and the limitations of adopting interpretable machine learning models in perioperative care.We advocate for transparent reporting,external validation,and careful consideration of clinically actionable timepoints before integration into practice.Ultimately,this work represents a valuable step toward precision risk stratification in gastric cancer surgery,and sets the stage for multicenter,prospective evaluations.
基金financial support of the National Natural Science Foundation of China(No.52371103)the Fundamental Research Funds for the Central Universities,China(No.2242023K40028)+1 种基金the Open Research Fund of Jiangsu Key Laboratory for Advanced Metallic Materials,China(No.AMM2023B01).financial support of the Research Fund of Shihezi Key Laboratory of AluminumBased Advanced Materials,China(No.2023PT02)financial support of Guangdong Province Science and Technology Major Project,China(No.2021B0301030005)。
文摘Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening particles also deteriorates the processability and it is of great importance to establish accurate processing maps to guide the thermomechanical processes to enhance the formability.In this study,we performed particle swarm optimization-based back propagation artificial neural network model to predict the high temperature flow behavior of 0.25wt%Al2O3 particle-reinforced Cu alloys,and compared the accuracy with that of derived by Arrhenius-type constitutive model and back propagation artificial neural network model.To train these models,we obtained the raw data by fabricating ODS Cu alloys using the internal oxidation and reduction method,and conducting systematic hot compression tests between 400 and800℃with strain rates of 10^(-2)-10 S^(-1).At last,processing maps for ODS Cu alloys were proposed by combining processing parameters,mechanical behavior,microstructure characterization,and the modeling results achieved a coefficient of determination higher than>99%.
基金financially supported by the National Science and Technology Major Project——Deep Earth Probe and Mineral Resources Exploration(No.2024ZD1003701)the National Key R&D Program of China(No.2022YFC2905004)。
文摘An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction,was conducted to extract useful feature information and recognize and classify rock images using Tensor Flow-based convolutional neural network(CNN)and Py Qt5.A rock image dataset was established and separated into workouts,confirmation sets,and test sets.The framework was subsequently compiled and trained.The categorization approach was evaluated using image data from the validation and test datasets,and key metrics,such as accuracy,precision,and recall,were analyzed.Finally,the classification model conducted a probabilistic analysis of the measured data to determine the equivalent lithological type for each image.The experimental results indicated that the method combining deep learning,Tensor Flow-based CNN,and Py Qt5 to recognize and classify rock images has an accuracy rate of up to 98.8%,and can be successfully utilized for rock image recognition.The system can be extended to geological exploration,mine engineering,and other rock and mineral resource development to more efficiently and accurately recognize rock samples.Moreover,it can match them with the intelligent support design system to effectively improve the reliability and economy of the support scheme.The system can serve as a reference for supporting the design of other mining and underground space projects.
文摘The rapid growth of biomedical data,particularly multi-omics data including genomes,transcriptomics,proteomics,metabolomics,and epigenomics,medical research and clinical decision-making confront both new opportunities and obstacles.The huge and diversified nature of these datasets cannot always be managed using traditional data analysis methods.As a consequence,deep learning has emerged as a strong tool for analysing numerous omics data due to its ability to handle complex and non-linear relationships.This paper explores the fundamental concepts of deep learning and how they are used in multi-omics medical data mining.We demonstrate how autoencoders,variational autoencoders,multimodal models,attention mechanisms,transformers,and graph neural networks enable pattern analysis and recognition across all omics data.Deep learning has been found to be effective in illness classification,biomarker identification,gene network learning,and therapeutic efficacy prediction.We also consider critical problems like as data quality,model explainability,whether findings can be repeated,and computational power requirements.We now consider future elements of combining omics with clinical and imaging data,explainable AI,federated learning,and real-time diagnostics.Overall,this study emphasises the need of collaborating across disciplines to advance deep learning-based multi-omics research for precision medicine and comprehending complicated disorders.
文摘Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML)has emerged as a powerful data analysis tool,widely applied in the prediction,diagnosis,and mechanistic study of kidney transplant rejection.This mini-review systematically summarizes the recent applications of ML techniques in post-kidney transplant rejection,covering areas such as the construction of predictive models,identification of biomarkers,analysis of pathological images,assessment of immune cell infiltration,and formulation of personalized treatment strategies.By integrating multi-omics data and clinical information,ML has significantly enhanced the accuracy of early rejection diagnosis and the capability for prognostic evaluation,driving the development of precision medicine in the field of kidney transplantation.Furthermore,this article discusses the challenges faced in existing research and potential future directions,providing a theoretical basis and technical references for related studies.
文摘With the enhancement of data collection capabilities,massive streaming data have been accumulated in numerous application scenarios.Specifically,the issue of classifying data streams based on mobile sensors can be formalized as a multi-task multi-view learning problem with a specific task comprising multiple views with shared features collected from multiple sensors.Existing incremental learning methods are often single-task single-view,which cannot learn shared representations between relevant tasks and views.An adaptive multi-task multi-view incremental learning framework for data stream classification called MTMVIS is proposed to address the above challenges,utilizing the idea of multi-task multi-view learning.Specifically,the attention mechanism is first used to align different sensor data of different views.In addition,MTMVIS uses adaptive Fisher regularization from the perspective of multi-task multi-view learning to overcome catastrophic forgetting in incremental learning.Results reveal that the proposed framework outperforms state-of-the-art methods based on the experiments on two different datasets with other baselines.
基金supported by the Key-Area Research and Development Program of Guangdong Province(Grant No.2019B010154002)the Guangdong Natural Science Foundation(Grant No.2022A1515010688)the National Natural Science Foundation of China(Grant No.61722304)。
文摘Label noise is often contained in the training data due to various human factors or measurement errors,which significantly causes a negative effect on classifiers.Despite many previous methods that have been proposed to learn robust classifiers,they are mainly based on the single-view feature.On the other hand,although existing multi-view classification methods benefit from the more comprehensive information,they rarely consider label noise.In this paper,we propose a novel label-noise robust classification model with multi-view learning to overcome these limitations.In the proposed model,not only the classifier learning but also the label-noise removal can benefit from the multi-view information.Specifically,we relax the label matrix of the basic multi-view least squares regression model,and develop a nonlinear transformation with a natural probabilistic approximation in the process of labels,which is conveniently optimized and beneficial to improve the discriminative ability of classifiers.Moreover,we preserve the intrinsic manifold structure of multi-view data on the relaxed label matrix,facilitating the process of label relaxation.For optimizing the proposed model with the nonlinear transformation,we derive a lemma about the partial derivation of the softmax related function,and develop an efficient alternating algorithm.Experimental evaluations on six real-world datasets confirm the advantages of the proposed method,compared to the related state-of-the-art methods.
基金Project supported by the National Natural Science Foundation of China(No.61572431)the National Key Technology R&D Program(No.2013BAH59F00)+1 种基金the Zhejiang Provincial Natural Science Foundation of China(No.LY13F020001)the Zhejiang Province Public Technology Applied Research Projects,China(No.2014C33090)
文摘Human action recognition is currently one of the most active research areas in computer vision. It has been widely used in many applications, such as intelligent surveillance, perceptual interface, and content-based video retrieval. However, some extrinsic factors are barriers for the development of action recognition; e.g., human actions may be observed from arbitrary camera viewpoints in realistic scene. Thus, view-invariant analysis becomes important for action recognition algorithms, and a number of researchers have paid much attention to this issue. In this paper, we present a multi-view learning approach to recognize human actions from different views. As most existing multi-view learning algorithms often suffer from the problem of lacking data adaptiveness in the nearest neighborhood graph construction procedure, a robust locally adaptive multi-view learning algorithm based on learning multiple local L 1-graphs is proposed. Moreover, an efficient iterative optimization method is proposed to solve the proposed objective function. Experiments on three public view-invariant action recognition datasets, i.e., ViHASi, IXMAS, and WVU, demonstrate data adaptiveness, effectiveness, and efficiency of our algorithm. More importantly, when the feature dimension is correctly selected （i.e., 〉60）, the proposed algorithm stably outperforms state-of-the-art counterparts and obtains about 6% improvement in recognition accuracy on the three datasets.
