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Short-chain fatty acids mediate enteric and central nervous system homeostasis in Parkinson’s disease:Innovative therapies and their translation 被引量:1
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作者 Shimin Pang Zhili Ren +1 位作者 Hui Ding Piu Chan 《Neural Regeneration Research》 2026年第3期938-956,共19页
Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’... Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease. 展开更多
关键词 ALPHA-SYNUCLEIN blood-brain barrier blood circulation central nervous system ENDOCRINE enteric nervous system glial cell gut-brain axis gut microbiota intestinal barrier neuron Parkinson’s disease short chain fatty acids vagus nerve
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An Improved Method Based on TODIM and TOPSIS for Multi-Attribute Decision-Making with Multi-Valued Neutrosophic Sets 被引量:4
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作者 Dongsheng Xu Lijuan Peng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2021年第11期907-926,共20页
Due to the complexity of decision-making problems and the subjectivity of decision-makers in practical application,it is necessary to adopt different forms of information expression according to the actual situation o... Due to the complexity of decision-making problems and the subjectivity of decision-makers in practical application,it is necessary to adopt different forms of information expression according to the actual situation of specific decision-making problems and choose the best method to solve them.Multi-valued neutrosophic set,as an extension of neutrosophic set,can more effectively and accurately describe incomplete,uncertain or inconsistent information.TODIM and TOPSIS methods are two commonly used multi-attribute decision-making methods,each of which has its advantages and disadvantages.This paper proposes a new method based on TODIM and TOPSIS to solve multi-attribute decision-making problems under multi-valued neutrosophic environment.After introducing the related theory of multi-valued neutrosophic set and the traditional TODIM and TOPSIS methods,the new method based on a combination of TODIM and TOPSIS methods is described.And then,two illustrative examples proved the feasibility and validity of the proposed method.Finally,the result has been compared with some existing methods under the same examples and the proposed method’s superiority has been proved.This paper studies this kind of decision-making problem from algorithm idea,algorithm steps and decision-making influencing factors. 展开更多
关键词 multi-valued neutrosophic set TODIM TOPSIS multi-attribute decision-making
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Multi-valued responses and dynamic stability of a nonlinear vibro-impact system with a unilateral non-zero offset barrier 被引量:1
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作者 徐伟 黄冬梅 谢文贤 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第3期91-99,共9页
In this paper, multi-valued responses and dynamic properties of a nonlinear vibro-impact system with a unilateral nonzero offset barrier are studied. Based on the Krylov-Bogoliubov averaging method and Zhuravlev non-s... In this paper, multi-valued responses and dynamic properties of a nonlinear vibro-impact system with a unilateral nonzero offset barrier are studied. Based on the Krylov-Bogoliubov averaging method and Zhuravlev non-smooth trans- formation, the frequency response, stability conditions, and the equation of backbone curve are derived. Results show that in some conditions impact system may have two or four steady-state solutions, which are interesting and not mentioned for a vibro-impact system with the existence of frequency island phenomena. Then, the classification of the steady-state solutions is discussed, and it is shown that the nontrivial steady-state solutions may lose stability by saddle node bifurcation and Hopf bifurcation. Furthermore, a criterion for avoiding the jump phenomenon is derived and verified. Lastly, it is found that the distance between the system's static equilibrium position and the barrier can lead to jump phenomenon under hardening type of nonlinearity stiffness. 展开更多
关键词 vibro-impact system multi-valued response frequency island stability
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Fixed Point of a Countable Family of Uniformly Totally Quasi- <i>&Oslash</i>-Asymptotically Nonexpansive Multi-Valued Mappings in Reflexive Banach Spaces with Applications 被引量:1
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作者 Yi Li 《Applied Mathematics》 2013年第9期6-12,共7页
The purpose of this article is to discuss a modified Halpern-type iteration algorithm for a countable family of uniformly totally quasi- ? -asymptotically nonexpansive multi-valued mappings and establish some strong c... The purpose of this article is to discuss a modified Halpern-type iteration algorithm for a countable family of uniformly totally quasi- ? -asymptotically nonexpansive multi-valued mappings and establish some strong convergence theorems under certain conditions. We utilize the theorems to study a modified Halpern-type iterative algorithm for a system of equilibrium problems. The results improve and extend the corresponding results of Chang et al. (Applied Mathematics and Computation, 218, 6489-6497). 展开更多
关键词 multi-valueD Mapping Totally Quasi- Ø -Asymptotically NONEXPANSIVE Countable FAMILY of UNIFORMLY Totally Quasi- Ø -Asymptotically NONEXPANSIVE multi-valueD Mappings Firmly Convergence
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Multi-Valued Neuron with Sigmoid Activation Function for Pattern Classification 被引量:2
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作者 Shen-Fu Wu Yu-Shu Chiou Shie-Jue Lee 《Journal of Computer and Communications》 2014年第4期172-181,共10页
Multi-Valued Neuron (MVN) was proposed for pattern classification. It operates with complex-valued inputs, outputs, and weights, and its learning algorithm is based on error-correcting rule. The activation function of... Multi-Valued Neuron (MVN) was proposed for pattern classification. It operates with complex-valued inputs, outputs, and weights, and its learning algorithm is based on error-correcting rule. The activation function of MVN is not differentiable. Therefore, we can not apply backpropagation when constructing multilayer structures. In this paper, we propose a new neuron model, MVN-sig, to simulate the mechanism of MVN with differentiable activation function. We expect MVN-sig to achieve higher performance than MVN. We run several classification benchmark datasets to compare the performance of MVN-sig with that of MVN. The experimental results show a good potential to develop a multilayer networks based on MVN-sig. 展开更多
关键词 PATTERN Classification multi-valueD NEURON (MVN) DIFFERENTIABLE ACTIVATION Function Backpropagation
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Importance Analysis of a Multi-state System Based on Direct Partial Logic Derivatives and Multi-valued Decision Diagrams 被引量:1
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作者 古莹奎 李晶 《Journal of Donghua University(English Edition)》 EI CAS 2014年第6期789-792,共4页
Importance analysis quantifies the critical degree of individual component. Compared with the traditional binary state system,importance analysis of the multi-state system is more aligned with the practice. Because th... Importance analysis quantifies the critical degree of individual component. Compared with the traditional binary state system,importance analysis of the multi-state system is more aligned with the practice. Because the multi-valued decision diagram( MDD) can reflect the relationship between the components and the system state bilaterally, it was introduced into the reliability calculation of the multi-state system( MSS). The building method,simplified criteria,and path search and probability algorithm of MSS structure function MDD were given,and the reliability of the system was calculated. The computing methods of importance based on MDD and direct partial logic derivatives( DPLD) were presented. The diesel engine fuel supply system was taken as an example to illustrate the proposed method. The results show that not only the probability of the system in each state can be easily obtained,but also the influence degree of each component and its state on the system reliability can be obtained,which is conducive to the condition monitoring and structure optimization of the system. 展开更多
关键词 multi-state system(MSS) importance analysis reliability multi-valued decision diagram(MDD) direct partial logic derivative(DPLD) diesel engine fuel supply system
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MULTI-VALUED TOTALLY QUASI-φ-ASYMPTOTICALLY NONEXPANSIVE SEMI-GROUPS AND STRONG CONVERGENCE THEOREMS IN BANACH SPACES
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作者 张石生 王林 赵云河 《Acta Mathematica Scientia》 SCIE CSCD 2013年第2期589-599,共11页
The purpose of this article is first to introduce the concept of multi-valued to- tally Quasi-φ-asymptotically nonexpansive semi-groups, which contains many kinds of semi- groups as its special cases, and then to mod... The purpose of this article is first to introduce the concept of multi-valued to- tally Quasi-φ-asymptotically nonexpansive semi-groups, which contains many kinds of semi- groups as its special cases, and then to modify the Halpern-Mann-type iteration algorithm for multi-valued totally Quasi-cS-asymptotically nonexpansive semi-groups to have the strong convergence under a limit condition only in the framework of Banach spaces. The results presented in this article improve and extend the corresponding results announced by many authors recently. 展开更多
关键词 multi-valued totally Quasi-q^-asymptotically nonexpansive semi-groups mod-ified Halpern-Mann-type iteration multi-valued quasi-qS-symptotically nonex-pansive semi-groups multi-valued quasi-~b-nonexpansive semi-groups multi-valued relatively nonexpansive semi-groups generalized projection
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Reliability Analysis of Satellite Turntable System under Multiple Operation Modes Based on Multi-Valued Decision Diagrams
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作者 Peng Zhang Zhijie Zhou +2 位作者 Yao Ding Dao Zhao Yijun Zhang 《Journal of Beijing Institute of Technology》 EI CAS 2023年第1期52-68,共17页
As a payload support system deployed on satellites,the turntable system is often switched among different working modes during the on-orbit operation,which can experience great state changes.In each mode,the missions ... As a payload support system deployed on satellites,the turntable system is often switched among different working modes during the on-orbit operation,which can experience great state changes.In each mode,the missions to be completed are different,consecutive and non-over-lapping,from which the turntable system can be considered to be a phased-mission system(PMS).Reliability analysis for PMS has been widely studied.However,the system mode cycle characteristic has not been taken into account before.In this paper,reliability analysis method of the satellite turntable system is proposed considering its multiple operation modes and mode cycle characteristic.Firstly,the multi-valued decision diagrams(MDD)manipulation rules between two adjacent mission cycles are proposed.On this basis,MDD models for the turntable system in different states are established and the reliability is calculated using the continuous time Markov chains(CTMC)method.Finally,the comparative study is carried out to show the effectiveness of our proposed method. 展开更多
关键词 phased-mission systems multi-valued decision diagrams continuous time Markov chains(CTMC) reliability analysis satellite turntable system
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The Uniform Convergence Topology On Multi-valued Mapping Space
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作者 辛玉梅 谢鸿政 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 1996年第2期1-5,共5页
Some convergences of topology are discussed. The definitions of almost uniform convergence topology and compatible topology are given. It is shown that the quasiuniform convergence and generalized uniform convergence ... Some convergences of topology are discussed. The definitions of almost uniform convergence topology and compatible topology are given. It is shown that the quasiuniform convergence and generalized uniform convergence have no compatible topology,but the almost uniform convergence has compatible topology. Moreover, the description of all uniform convergence limits and their mutual relation are investigated[1]. 展开更多
关键词 ss: TOPOLOGICAL SPACE multi-valueD mapping limit-cluster line
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COMMON FIXED POINT THEOREMS FOR MULTI-VALUED MAPS
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作者 Boško Damjanovic Bessem Samet Calogero Vetro 《Acta Mathematica Scientia》 SCIE CSCD 2012年第2期818-824,共7页
We establish some results on coincidence and common fixed points for a twopair of multi-valued and single-valued maps in complete metric spaces. Presented theorems generalize recent results of Gordji et al [4] and sev... We establish some results on coincidence and common fixed points for a twopair of multi-valued and single-valued maps in complete metric spaces. Presented theorems generalize recent results of Gordji et al [4] and several results existing in the literature. 展开更多
关键词 Coincidence point common fixed point multi-valued maps
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Common Fixed Point Theorems of Multi-Valued Maps in Ultra Metric Space
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作者 Qiulin Wang Meimei Song 《Applied Mathematics》 2013年第2期417-420,共4页
We establish some results on coincidence and common fixed point for a two pair of multi-valued and single-valued maps in ultra metric spaces.
关键词 multi-valueD Maps COINCIDENCE POINT Common Fixed POINT
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A NOVEL MULTI-VALUED BAM MODEL WITH IMPROVED ERROR-CORRECTING CAPABILITY
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作者 Zhang Daoqiang Chen Songcan (College of Info. Sci. Tech., Nanjing Univ. of Aeronautics and Astronautics, Nanjing 210016) 《Journal of Electronics(China)》 2003年第3期220-223,共4页
A Hyperbolic Tangent multi-valued Bi-directional Associative Memory (HTBAM) model is proposed in this letter. Two general energy functions are defined to prove the stability of one class of multi-valued Bi-directional... A Hyperbolic Tangent multi-valued Bi-directional Associative Memory (HTBAM) model is proposed in this letter. Two general energy functions are defined to prove the stability of one class of multi-valued Bi-directional Associative Mernorys(BAMs), with HTBAM being the special case. Simulation results show that HTBAM has a competitive storage capacity and much more error-correcting capability than other multi-valued BAMs. 展开更多
关键词 Bi-directional associative memory Recurrent neural network multi-value
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A Fixed Point Theorem for Multi-valued Composite Increasing Operators
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作者 李凤友 刘云生 《Chinese Quarterly Journal of Mathematics》 CSCD 1995年第3期59-61,共3页
In this paper,we give a fixed point theorem for multi-valued composite increasing operators, which generalizes the theorem of the paper [1] under not only multi-valued mappings but also single-valued mappings. And we... In this paper,we give a fixed point theorem for multi-valued composite increasing operators, which generalizes the theorem of the paper [1] under not only multi-valued mappings but also single-valued mappings. And we generalizes the corresponding results of [2]-[5]. 展开更多
关键词 semiordered topological space multi-valued increasing operator upper-semiclosed set fixed point
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A Fixed Point Theorem for Multi-valued Composite Increasing Operators in Partially Ordered Spaces
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作者 杨新华 《Chinese Quarterly Journal of Mathematics》 CSCD 1997年第1期95-97, ,共3页
In this paper,we give a fixed point theorem for multi-valued composite increasing operators,in partially ordered spaces,which generalizes the results of [1]-[3] and [5]- [8].
关键词 semiordered topological space multi-valued increasing operator upper-semiclosed set fixed point
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Cotangent Similarity Measure of Consistent Neutrosophic Sets and Application to Multiple Attribute Decision-Making Problems in Neutrosophic Multi-Valued Setting
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作者 Angyan Tu Jiancheng Chen Bing Wang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2022年第11期377-387,共11页
A neutrosophic multi-valued set(NMVS)is a crucial representation for true,false,and indeterminate multivalued information.Then,a consistent single-valued neutrosophic set(CSVNS)can effectively reflect the mean and con... A neutrosophic multi-valued set(NMVS)is a crucial representation for true,false,and indeterminate multivalued information.Then,a consistent single-valued neutrosophic set(CSVNS)can effectively reflect the mean and consistency degree of true,false,and indeterminate multi-valued sequences and solve the operational issues between different multi-valued sequence lengths in NMVS.However,there has been no research on consistent single-valued neutrosophic similarity measures in the existing literature.This paper proposes cotangent similarity measures and weighted cotangent similarity measures between CSVNSs based on cotangent function in the neutrosophic multi-valued setting.The cosine similarity measures showthe cosine of the angle between two vectors projected into amultidimensional space,rather than their distance.The cotangent similaritymeasures in this study can alleviate several shortcomings of cosine similarity measures in vector space to a certain extent.Then,a decisionmaking approach is presented in viewof the established cotangent similarity measures in the case of NMVSs.Finally,the developed decision-making approach is applied to selection problems of potential cars.The proposed approach has obtained two different results,which have the same sort sequence as the compared literature.The decision results prove its validity and effectiveness.Meantime,it also provides a new manner for neutrosophic multi-valued decision-making issues. 展开更多
关键词 Neutrosophic multi-valued set consistency single-valued neutrosophic sets cotangent similarity measure multiple attribute decision-making
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ALGORITHMS FOR A SYSTEM OF GENERALIZED MIXED EQUILIBRIUM PROBLEMS AND A COUNTABLE FAMILY OF SOME NONLINEAR MULTI-VALUED NONEXPANSIVE-TYPE MAPS
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作者 Ogonnaya Michael ROMANUS Ukamaka Victoria NNYABA Monday Ogudu NNAKWE 《Acta Mathematica Scientia》 SCIE CSCD 2018年第6期1805-1820,共16页
In this paper, relaxed iterative algorithms of Krasnoselskii-type and Halpern-type that approximate a solution of a system of a generalized mixed equilibrium problem anda common fixed point of a countable family of to... In this paper, relaxed iterative algorithms of Krasnoselskii-type and Halpern-type that approximate a solution of a system of a generalized mixed equilibrium problem anda common fixed point of a countable family of totally quasi-C-asymptotically nonexpansivemulti-valued maps are constructed. Strong convergence of the sequence generated by thesealgorithms is proved in uniformly smooth and strictly convex real Banach spaces with Kadec-Klee property. Furthermore, several applications of our theorems are also presented. Finally,our theorems are significant improvements on several important recent results for this classof nonlinear problems. 展开更多
关键词 Halpern-type algorithm Krasnoselskii-type algorithm system of generalizedmixed equilibrium problems totally quasi-C-asymptotically nonexpansive multi-valued maps equally continuous maps
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On the (<i>r</i>,<i>φ</i>,<i>ψ</i>)-Suzuki Contraction for the Multi-Valued Mappings
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作者 Zamir Selko 《Journal of Applied Mathematics and Physics》 2021年第2期211-219,共9页
In this work we try to give a new contraction type in multi-valued mapping on complete metric spaces. We prove the existence of fixed point for (<i>r</i>,<i>φ</i>,<i>ψ</i>)-Suzuki... In this work we try to give a new contraction type in multi-valued mapping on complete metric spaces. We prove the existence of fixed point for (<i>r</i>,<i>φ</i>,<i>ψ</i>)-Suzuki contraction in such spaces. Around our paper, the function <i>ψ</i> is absolutely continuous, and in this case, the contraction proposed by as has a fixed point. 展开更多
关键词 Suzuki-Contraction multi-valued Mappings Fixed Point Theorem Absolutely Continuous Functions
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Cybersecurity Challenges and Technological Integration in Military Supply Chain 4.0 被引量:1
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作者 Nathalie Essi Afefa Takpah Victor Nosakhare Oriakhi 《Journal of Information Security》 2025年第1期131-148,共18页
The concept of Supply Chain 4.0 represents a transformative phase in supply chain management through advanced digital technologies like IoT, AI, blockchain, and cyber-physical systems. While these innovations deliver ... The concept of Supply Chain 4.0 represents a transformative phase in supply chain management through advanced digital technologies like IoT, AI, blockchain, and cyber-physical systems. While these innovations deliver operational improvements, the heightened interconnectivity introduces significant cybersecurity challenges, particularly within military logistics, where mission-critical operations and life-safety concerns are paramount. This paper examines these unique cybersecurity requirements, focusing on advanced persistent threats, supply chain poisoning, and data breaches that could compromise sensitive operations. The study proposes a hybrid cybersecurity framework tailored to military logistics, integrating resilience, redundancy, and cross-jurisdictional security measures. Real-world applicability is validated through simulations, offering strategies for securing supply chains while balancing security, efficiency, and flexibility. 展开更多
关键词 CYBERSECURITY Supply chain IOT Blockchain Artificial Intelligence
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Epoxy-Based Chain Extenders in Polylactic Acid (PLA): A Comprehensive Review of Structure, Performance, and Challenges 被引量:1
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作者 Hao Duan Xiaoyan Shang +3 位作者 Xihao Wu Liuliu Ma Chen Xing Jun Zhu 《Journal of Materials Science and Chemical Engineering》 2025年第1期20-44,共25页
Amid the escalating plastic pollution issue, the development of biodegradable and recyclable polymeric materials has become a focus within the scientific community. Chain extenders, which are an important class of com... Amid the escalating plastic pollution issue, the development of biodegradable and recyclable polymeric materials has become a focus within the scientific community. Chain extenders, which are an important class of compounds, facilitate the elongation of polymer chains through reactive functional groups, thereby enhancing the performance of the materials. Epoxy-based chain extenders, due to their cost-effectiveness, low toxicity, high reaction efficiency, and effective reactivity with hydroxyl and carboxyl groups, have emerged as a promising class of chain extenders. This manuscript comprehensively elaborates on the varieties, structural characteristics, and performance of chain extenders, the challenges they face, and the methods for their modification. Special emphasis is placed on the application of epoxy-based chain extenders in biodegradable polymers, such as polylactic acid (PLA), and their subsequent influence on the structural and performance properties of these materials. 展开更多
关键词 chain Extender Epoxy Type GMA BIODEGRADABLE PLA RECYCLE
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