Facing the economic challenges of significant frequency regulation wear and tear on thermal power units and short energy storage lifespan in thermal-energy storage combined systems participating in grid primary freque...Facing the economic challenges of significant frequency regulation wear and tear on thermal power units and short energy storage lifespan in thermal-energy storage combined systems participating in grid primary frequency regulation(PFR),this paper proposes a novel hybrid energy storage system(HESS)control strategy based on Newton-Raphson optimization algorithm(NRBO)-VMD and a fuzzy neural network(FNN)for PFR.In the primary power allocation stage,the high inertia and slow response of thermal power units prevent them from promptly responding to the high-frequency components of PFR signals,leading to increased mechanical stress.To address the distinct response characteristics of thermal units and HESS,an NRBO-VMD based decomposition method for PFR signals is proposed,enabling a flexible system response to grid frequency deviations.Within the HESS,an adaptive coordinated control strategy and a State of Charge(SOC)self-recovery strategy are introduced.These strategies autonomously adjust the virtual inertia and droop coefficients based on the depth of frequency regulation and the real-time SOC.Furthermore,a FNN is constructed to perform secondary refinement of the internal power distribution within the HESS.Finally,simulations under various operational conditions demonstrate that the proposed strategy effectively mitigates frequent power adjustments of the thermal unit during PFR,adaptively achieves optimal power decomposition and distribution,maintains the flywheel energy storage’s SOC within an optimal range,and ensures the long-term stable operation of the HESS.展开更多
Endochondral ossification is a physiological process involving a sequential formation of cartilage and bone tissues.Classically,cartilage and bone formation have been considered independent processes at cellular level...Endochondral ossification is a physiological process involving a sequential formation of cartilage and bone tissues.Classically,cartilage and bone formation have been considered independent processes at cellular level.However,the recently described multiple cell differentiation dynamics suggest that some bone cells are indeed the progeny of cartilage cells,or chondrocyte-derived osteoblasts.We hypothesized that the cartilage-to-bone phenotype transition is triggered by specific molecular events.First,the process was assessed in mouse bone tissue,and then,it was mimicked using in vivo cell implantation and in vitro serial differentiation protocols.Data indicates that cartilage cells transition to bone cell phenotype during postnatal physiological bone formation.This process can be reproduced using cartilage precursor cells coupled to specific implantation procedures or differentiation protocols.Gene expression profiling reveals that NOTCH,BMP and MAPK signaling pathways are relevant at the phenotype-switch,while the transcription factors Mesp1,Alx1,Grhl3 and Hmx3 are the feasible driver genes for chondrocyte-derived osteoblasts formation.Altogether,this report shows that endochondral ossification can be modeled using primary cell cultures and data indicate that this process is regulated by specific molecular events,previously described at skeleton morphogenesis during embryo development,and from now on also linkable to postnatal bone development and regeneration processes.展开更多
Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the reg...Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the regulatory mechanisms governing flavonoid biosynthesis in fruits.Phytohormones are involved in the regulation of flavonoid biosynthesis.The abscisic acid,ethylene,jasmonic acid,cytokinins,and brassinosteroids promote flavonoid biosynthesis,while auxin negatively regulates flavonoid biosynthesis.Subsequently,transcription factors from the MYB,bHLH,WRKY,NAC,and bZIP families are pivotal in regulating flavonoid biosynthesis.In addition,non-coding RNAs(microRNA and lncRNA)also participate in the regulation of flavonoids biosynthesis.MicroRNAs are generally believed to negatively regulate flavonoid metabolism in fruits,while lncRNAs have the opposite effect.Furthermore,the interactions between plant hormones,transcription factors,and non-coding RNAs in fruit flavonoid biosynthesis were analyzed.Ultimately,a foundational regulatory network for fruit flavonoid biosynthesis was hereby established.展开更多
Lymphatic vessel networks have been identified in the meninges of mice,non-human primates,and humans[1].Meningeal lymphatic vessels(mLVs),composed of meningeal lymphatic endothelial cells(mLECs),are present in both ze...Lymphatic vessel networks have been identified in the meninges of mice,non-human primates,and humans[1].Meningeal lymphatic vessels(mLVs),composed of meningeal lymphatic endothelial cells(mLECs),are present in both zebrafish and mammals,although their anatomical distributions differ;they reside in the dura mater in mice,but are situated within the meninges in zebrafish[2].Moreover,the lymphatic marker genes expressed in these vessels differ between species[2].展开更多
The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the exis...The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the existing research has not deeply explored the EV active-reactive synergistic regulating characteristics,and failed to realize themulti-timescale synergistic control with other regulatingmeans,For this reason,this paper proposes amultilevel linkage coordinated optimization strategy to reduce the voltage deviation of the distribution network.Firstly,a capacitor bank reactive power compensation voltage control model and a distributed photovoltaic(PV)activereactive power regulationmodel are established.Additionally,an external characteristicmodel of EVactive-reactive power regulation is developed considering the four-quadrant operational characteristics of the EVcharger.Amultiobjective optimization model of the distribution network is then constructed considering the time-series coupling constraints of multiple types of voltage regulators.A multi-timescale control strategy is proposed by considering the impact of voltage regulators on active-reactive EV energy consumption and PV energy consumption.Then,a four-stage voltage control optimization strategy is proposed for various types of voltage regulators with multiple time scales.Themulti-objective optimization is solved with the improvedDrosophila algorithmto realize the power fluctuation control of the distribution network and themulti-stage voltage control optimization.Simulation results validate that the proposed voltage control optimization strategy achieves the coordinated control of decentralized voltage control resources in the distribution network.It effectively reduces the voltage deviation of the distribution network while ensuring the energy demand of EV users and enhancing the stability and economic efficiency of the distribution network.展开更多
Under the dual background of global urbanization and climate change,challenges such as urban waterlogging,degradation of water environment,and fragmentation of biological habitats are intensifying.Advancing the transf...Under the dual background of global urbanization and climate change,challenges such as urban waterlogging,degradation of water environment,and fragmentation of biological habitats are intensifying.Advancing the transformation of blue-green infrastructure from a single function to multiple coordinated functions has emerged as a critical path for enhancing urban ecological resilience.The Catharijnesingel Canal Park in Utrecht,the Netherlands,serves as a case study to investigate the synergistic interaction of hydrological regulation and habitat network construction through the transformation of historical canals from grey to blue-green infrastructure.Initially,the implementation path of this“blue-green renaissance”is analyzed,followed by a detailed examination of the spatial realization patterns and mechanisms underlying hydrology and habitat synergy,focusing on river form remodeling,vegetation community alignment,and precise habitat design.The results indicate that the collaborative model of“hydrology and habitat”coupling not only enhances rain-flood resilience,biodiversity,and the quality of public spaces in urban areas but also serves as a reference model for high-density urban regeneration by integrating space,ecology,and efficiency.This model offers both a theoretical foundation and practical guidance for Chinese cities aiming to achieve functional integration and synergistic interaction in ecological restoration and the development of bluegreen spaces.展开更多
Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the p...Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the production line,the manufacturing layer and the workshop layer.The dynamics of re-entrant production lines are governed by hyperbolic partial differential equations(PDEs)based on the law of mass conservation.展开更多
In the energy regulation based varibable-speed electrohydraulic drive system, the supply energy and the demanded energy, which will affect the control performance greatly, are crucial. However, they are hard to be obt...In the energy regulation based varibable-speed electrohydraulic drive system, the supply energy and the demanded energy, which will affect the control performance greatly, are crucial. However, they are hard to be obtained via conventional methods for some reasons. This paper tries to a new route： the definitive numerical values of the supply energy and the demanded energy are not required, except for their relationship which is called energy state. A three-layer back propagation（BP） neural network was built up to act as an energy analysis unit to deduce the energy state. The neural network has three inputs： the reference displacement, the actual displacement of cylinder rod and the system flowrate supply. The output of the neural network is energy state. A Chebyshev type II filter was designed to calculate the cylinder speed for the estimation of system flowrate supply. The training and testing samples of neural network were collected by the system accurate simulation model. After off-line training, the neural network was tested by the testing data. And the testing result demonstrates that the designed neural network was successful. Then, the neural network acts as the energy analysis unit in real-time experiments of cylinder position control, where it works efficiently under square-wave and sine-wave reference displacement. The experimental results validate its feasibility and adaptability. Only a position sensor and some pressure sensors, which are cheap and have quick dynamic response, are necessary for the system control. And the neural network plays the role of identifying the energy state.展开更多
OBJECTIVE: To analyze part of the mechanism of electroacupuncture on Sishencong(EX-HN1) for strokerelated sleep disorders(SSD) and post-stroke cognitive impairment(PSCI). METHODS: Using a randomized controlled trial(R...OBJECTIVE: To analyze part of the mechanism of electroacupuncture on Sishencong(EX-HN1) for strokerelated sleep disorders(SSD) and post-stroke cognitive impairment(PSCI). METHODS: Using a randomized controlled trial(RCT) design, 72 patients were assigned to the electroacupuncture(EA) group or the sham acupuncture(SA) group. A healthy control(HC) group was also included. Both groups were given routine rehabilitation treatment. Then, patients in the EA group were given additional electroacupuncture at Sishencong(EX_HN1). Meanwhile, patients in the SA group were given a flat-head needle sham/placebo treatment placed at the bilateral Jianyu (LI15) and Binao(LI14) line midpoints and the Jianyu(LI15) and Jianzhen(SI9) line midpoints. Before and after treatment, scales were collected and analyzed. In the second phase of the study, some subjects from the EA group were selected for functional magnetic resonance imaging(f MRI) data acquisition and comparative analysis with the HC group using a non-RCT design. RESULTS: The EA group performed better than the SA group on the Pittsburgh sleep quality index(PSQI), Montreal cognitive assessment basic(Mo CA_B), selfrating anxiety scale(SAS), and self-rating depression scale(SDS). Analysis of the f MRI showed that lowfrequency(2 Hz) electroacupuncture stimulation at Sishencong(EX_HN1) can restrain frontal sup medial right(SFGmed.R), precuneus right(PCUN.R), and posterior cingulate cortex right(PCC.R) and enhance angular left(ANG.L), parietal inf left(IPL.L) and occipital mid left(MOG.L). The functional connectivity(FC) of SFGmed.R was positively correlated with PSQI. Electroacupuncture stimulation at Sishencong(EX_HN1) can reduce the side efficiency of the whole brain connection with the Thalamus.L, Hippocampus.L, and Occipital.Mid.L. CONCLUSIONS: Low frequency(2 Hz) electroacupuncture stimulation at Sishencong(EX_HN1) can simultaneously improve sleep quality, negative emotions, and cognitive functions, the first two of which may be related to SFGmed.R restraint. Electroacupuncture can make some brain areas approach the physiological bias state, which is characterized by dominant hemispheric enhancement and non-dominant hemispheric weakening. The reduced whole brain connection side efficiency with some key nodes of the brain net may relate to sleep quality improvements in SSD patients.展开更多
The aviation oxygen mask,which has a small volume of less than 1L and strong air tightness,imposes extremely high requirements on control performance of the oxygen regulator.Based on analyses of the operation principl...The aviation oxygen mask,which has a small volume of less than 1L and strong air tightness,imposes extremely high requirements on control performance of the oxygen regulator.Based on analyses of the operation principle of oxygen supply system,the dynamic model is established through the combination of mechanism analysis and experimental data.Considering that the traditional fixed-parameter controllers are difficult to meet the control requirements with changes in pulmonary ventilation,this paper presents an online feedback controller based on neural network compensation(NNC),with connection weights that can be updated without pre-training.Then mathematical simulations at different respiratory parameters,such as respiratory rate,are performed to verify the superior lower inspiratory resistance of controller with NNC.In terms of hardware,an embedded AI control platform is to complete the experimental verification.Furthermore,the work may have downward compatibility to achieve stable oxygen supply in civil fields,such as medical ventilators,high-altitude expeditions.展开更多
We are deeply interested in the recent findings onβ-arrestin 2.Liu et al demonstrated thatβ-arrestin 2 knockout provides significant protection in diabetic nephropathy,underscoring its potential as a promising thera...We are deeply interested in the recent findings onβ-arrestin 2.Liu et al demonstrated thatβ-arrestin 2 knockout provides significant protection in diabetic nephropathy,underscoring its potential as a promising therapeutic target for diabetic nephropathy treatment.Furthermore,the role ofβ-arrestin 2 in metabolic regulation is equally critical,particularly in insulin signaling,hepatic glucose production,and adipose tissue function.Althoughβ-arrestin 2 plays a distinct role in metabolism and kidney protection,its tissue-specific regulation opens up valuable avenues for developing targeted therapeutic strategies centered onβ-arrestin 2.展开更多
Regulation plays a pivotal role in mitigating the spread of rumors, serving as a vital tool for maintaining social stability and facilitating its evolution. A central challenge lies in establishing an effective regula...Regulation plays a pivotal role in mitigating the spread of rumors, serving as a vital tool for maintaining social stability and facilitating its evolution. A central challenge lies in establishing an effective regulatory framework despite limited resources available for combating rumor propagation. To address this challenge, this paper proposes a dynamic and adaptive regulatory system. First, based on observed regulatory patterns in real-world social networks, the rumor propagation process is divided into two distinct phases: regulation and intervention. Regulatory intensity is introduced as an indicator of user state transitions. Unlike traditional, non-adaptive regulatory models that allocate costs uniformly,the adaptive model facilitates flexible cost distribution through a manageable individual regulatory intensity. Moreover,by introducing adaptive strength, the two cost allocation models are integrated within a unified framework, leading to the development of a dynamic model for rumor suppression. Finally, simulation experiments on Barabási–Albert(BA)networks demonstrate that the adaptive regulatory mechanism significantly reduces both the scope and duration of rumor propagation. Furthermore, when traditional non-adaptive regulatory models show limited effectiveness, the adaptive model effectively curbs rumor propagation by optimizing cost allocation between regulatory and intervention processes, and by adjusting per-unit cost benefit differentials.展开更多
First, the paper analyzes the advantages and disadvantages of all kinds of reactive power compensation technology, and then proposes a principle and integrated control strategy of the composite operation of TSC and SV...First, the paper analyzes the advantages and disadvantages of all kinds of reactive power compensation technology, and then proposes a principle and integrated control strategy of the composite operation of TSC and SVG, also the paper designs and develops the main controller of Network based composite power quality regulation device, based on RTDS, the real-time digital simulation model of The Device is established, and finally the prototype of the device is developed with the function of filter and split-phase compensation. The main controller determines the cooperative operation of both TSC and SVG, and the switching strategy of TSC. The simulation result in RTDS can verify the precision of the measure system and the validity of the control logic, the prototype has finished the type test according to the national standard.展开更多
Although the significant roles of magnetic induction and electromagnetic radiation in the neural system have been widely studied,their influence on Parkinson’s disease(PD)has yet to be well explored.By virtue of the ...Although the significant roles of magnetic induction and electromagnetic radiation in the neural system have been widely studied,their influence on Parkinson’s disease(PD)has yet to be well explored.By virtue of the magnetic flux variable,this paper studies the transition of firing patterns induced by magnetic induction and the regulation effect of external magnetic radiation on the firing activities of the subthalamopallidal network in basal ganglia.We find:(i)The network reproduces five typical waveforms corresponding to the severity of symptoms:weak cluster,episodic,continuous cluster,episodic,and continuous wave.(ii)Magnetic induction is a double-edged sword for the treatment of PD.Although the increase of magnetic coefficient may lead the physiological firing activity to transfer to pathological firing activity,it also can regulate the pathological intensity firing activity with excessiveβ-band power transferring to the physiological firing pattern with weakβ-band power.(iii)External magnetic radiation could inhibit continuous tremulous firing andβ-band power of subthalamic nucleus(STN),which means the severity of symptoms weakened.Especially,the bi-parameter plane of the regulation region shows that a short pulse period of magnetic radiation and a medium level of pulse percentage can well regulate pathological oscillation.This work helps to understand the firing activity of the subthalamopallidal network under electromagnetic effect.It may also provide insights into the mechanisms behind the electromagnetic therapy of PD-related firing activity.展开更多
The advent of the Next Generation Network(NGN),a new service-driven network,urges the telecom service operators to consider transforming from single-service providers to full-service providers.During the transformatio...The advent of the Next Generation Network(NGN),a new service-driven network,urges the telecom service operators to consider transforming from single-service providers to full-service providers.During the transformation,they should be concerned about the network user number and the network quality as well as the value added network information.The low threshold for service provision brings a new breed of service providers,which impacts upon the current regulation policy.To adapt to the development of the NGN,it is a necessity to improve the regulation policy in terms of service operators management,user management,Quality of Service(QoS)assurance,service monitoring,charging,and settlement.Meanwhile,regulatory authorities should establish a new body as quickly as possible to meet the trend of the NGN convergence.The new regulatory body would be responsible for regulating operators who will be awarded full-service licenses,and managing new service providers effectively to guarantee the user’s interests.展开更多
With the national electrification level getting higher and higher, peoples dependence on electric energy in production and life is also getting higher and higher. Therefore, people will pay more and more attention to ...With the national electrification level getting higher and higher, peoples dependence on electric energy in production and life is also getting higher and higher. Therefore, people will pay more and more attention to the stable operation of the power system. Electricity is also indispensable to the mechanical work in industry, to all kinds of mechanical work in rural areas, and to all kinds of household appliances in daily life. Therefore, to ensure the stable operation of the urban distribution network can not only meet the needs of peoples lives, but also the inevitable needs of economic and social production development. This paper focuses on the in-depth analysis of the operation and management of the urban distribution network, and also gives some suggestions on the operation and management of the county distribution network.展开更多
In this paper,a dynamic flow-regulation algorithm-oriented network overload control is proposed.It can proportion-ally distribute the load between the high-degree nodes and the low-degree nodes.According to the theore...In this paper,a dynamic flow-regulation algorithm-oriented network overload control is proposed.It can proportion-ally distribute the load between the high-degree nodes and the low-degree nodes.According to the theoretical analysis,the net-work transmission performance of the proposed algorithm is in inverse proportion to the usage rate of the high-degree nodes.Simulations show that the new algorithm is more flexible and can enhance the network capability in most circumstances compared with the shortest path routing algorithm.Moreover,the compari-son with the efficient routing algorism also reveals the prominent performance of the new algorithm.展开更多
Objectives:The current treatment options and therapeutic targets for triple-negative breast cancer(TNBC),an aggressive subtype of breast cancer(BrCA),are limited.This study aimed to identify novel biomarkers and trans...Objectives:The current treatment options and therapeutic targets for triple-negative breast cancer(TNBC),an aggressive subtype of breast cancer(BrCA),are limited.This study aimed to identify novel biomarkers and transcriptional regulatory networks(TRN)inherent in TNBC samples.Methods:We analyzed pan-cancer BrCA datasets from The Cancer Genome Atlas(TCGA)to compare triple-positive breast cancer(TPBC)with TNBC.TRN algorithms and virtual inference of protein-enriched regulon(VIPER)were used to identify master regulators and their target genes.Utilizing TNBC cells(MDA-MB-231 and MDA-MB-468),we validated the relationship of nuclear factor erythroid 2-like 3(NFE2L3)and basic helix-loop-helix family member E 40(BHLHE40)by performing a luciferase assay.The expression levels of these targets were measured after transfections with plasmid and siRNA via qRT-PCR and western blots.The effect of these genes on cell proliferation and migration was studied using phenotypic assays.Results:Using computational approaches,we identified NFE2L3 as a master regulator with BHLHE40 as its target gene.NFE2L3 protein binds to the promoter region of BHLHE40 and regulates its transcriptional activity.Additionally,silencing and overexpressing NFE2L3 and BHLHE40 in TNBC cell lines MDA-MB-231 and MDA-MB-468 showed that NFE2L3 directly regulates BHLHE40 at both transcriptional and translational levels.We found that BHLHE40 requires NFE2L3 for cell proliferation and migration in TNBC.Conclusion:These findings underscore the significance of NFE2L3 and BHLHE40 in TNBC,highlighting NFE2L3’s role in regulating the oncogenic activity of BHLHE40 in TNBC cells.展开更多
Multi-target tracking(MTT) is a research hotspot of wireless sensor networks at present.A self-organized dynamic cluster task allocation scheme is used to implement collaborative task allocation for MTT in WSN and a s...Multi-target tracking(MTT) is a research hotspot of wireless sensor networks at present.A self-organized dynamic cluster task allocation scheme is used to implement collaborative task allocation for MTT in WSN and a special cluster member(CM) node selection method is put forward in the scheme.An energy efficiency model was proposed under consideration of both energy consumption and remaining energy balance in the network.A tracking accuracy model based on area-sum principle was also presented through analyzing the localization accuracy of triangulation.Then,the two models mentioned above were combined to establish dynamic cluster member selection model for MTT where a comprehensive performance index function was designed to guide the CM node selection.This selection was fulfilled using genetic algorithm.Simulation results show that this method keeps both energy efficiency and tracking quality in optimal state,and also indicate the validity of genetic algorithm in implementing CM node selection.展开更多
The acute effect of acupuncture on Alzheimer's disease,i.e.,on brain activation during treatment,has been reported.However,the effect of long-term acupuncture on brain activation in Alzheimer's disease is uncl...The acute effect of acupuncture on Alzheimer's disease,i.e.,on brain activation during treatment,has been reported.However,the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear.Therefore,in this study,we performed long-term needling at Zusanli(ST36)or a sham point(1.5 mm lateral to ST36)in a rat Alzheimer's disease model,for 30 minutes,once per day,for 30 days.The rats underwent 18F-fluorodeoxyglucose positron emission tomography scanning.Positron emission tomography images were processed with SPM2.The brain areas activated after needling at ST36 included the left hippocampus,the left orbital cortex,the left infralimbic cortex,the left olfactory cortex,the left cerebellum and the left pons.In the sham-point group,the activated regions were similar to those in the ST36 group.However,the ST36 group showed greater activation in the cerebellum and pons than the sham-point group.These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer's disease.展开更多
基金supported by the Lanzhou Science and Technology Plan Project(XM1753694781389).
文摘Facing the economic challenges of significant frequency regulation wear and tear on thermal power units and short energy storage lifespan in thermal-energy storage combined systems participating in grid primary frequency regulation(PFR),this paper proposes a novel hybrid energy storage system(HESS)control strategy based on Newton-Raphson optimization algorithm(NRBO)-VMD and a fuzzy neural network(FNN)for PFR.In the primary power allocation stage,the high inertia and slow response of thermal power units prevent them from promptly responding to the high-frequency components of PFR signals,leading to increased mechanical stress.To address the distinct response characteristics of thermal units and HESS,an NRBO-VMD based decomposition method for PFR signals is proposed,enabling a flexible system response to grid frequency deviations.Within the HESS,an adaptive coordinated control strategy and a State of Charge(SOC)self-recovery strategy are introduced.These strategies autonomously adjust the virtual inertia and droop coefficients based on the depth of frequency regulation and the real-time SOC.Furthermore,a FNN is constructed to perform secondary refinement of the internal power distribution within the HESS.Finally,simulations under various operational conditions demonstrate that the proposed strategy effectively mitigates frequent power adjustments of the thermal unit during PFR,adaptively achieves optimal power decomposition and distribution,maintains the flywheel energy storage’s SOC within an optimal range,and ensures the long-term stable operation of the HESS.
基金funded by Grants PID2021-127191OB-I00,RTI2018-101708-A-I00,PRE2018-084542 and PRE2022-102680 funded by MCIN/AEI/10.13039/501100011033 and by“ERDF A way of making Europe”Grant RYC2018-025502-I is funded by MCIN/AEI/10.13039/501100011033 and by“ESF Investing in your future”+1 种基金Grant MDM-20170720 Maria de Maeztu Units of Excellence Program funded by the Spanish State Research Agencysupported by Instituto de Salud CarlosⅢ,Infrastructure of Precision Medicine associated with Science and Technology(IMPaCT)of the Strategic Action in Health(iDATA-MP)。
文摘Endochondral ossification is a physiological process involving a sequential formation of cartilage and bone tissues.Classically,cartilage and bone formation have been considered independent processes at cellular level.However,the recently described multiple cell differentiation dynamics suggest that some bone cells are indeed the progeny of cartilage cells,or chondrocyte-derived osteoblasts.We hypothesized that the cartilage-to-bone phenotype transition is triggered by specific molecular events.First,the process was assessed in mouse bone tissue,and then,it was mimicked using in vivo cell implantation and in vitro serial differentiation protocols.Data indicates that cartilage cells transition to bone cell phenotype during postnatal physiological bone formation.This process can be reproduced using cartilage precursor cells coupled to specific implantation procedures or differentiation protocols.Gene expression profiling reveals that NOTCH,BMP and MAPK signaling pathways are relevant at the phenotype-switch,while the transcription factors Mesp1,Alx1,Grhl3 and Hmx3 are the feasible driver genes for chondrocyte-derived osteoblasts formation.Altogether,this report shows that endochondral ossification can be modeled using primary cell cultures and data indicate that this process is regulated by specific molecular events,previously described at skeleton morphogenesis during embryo development,and from now on also linkable to postnatal bone development and regeneration processes.
基金supported by the China Agricultural Research System(Grant No.CARS-09)the Central Government Guiding Local Science and Technology Development Project(Grant No.YDZX2023029)the Gansu Planning Projects on Science and Technology(Grant No.23CXNJ0013).
文摘Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the regulatory mechanisms governing flavonoid biosynthesis in fruits.Phytohormones are involved in the regulation of flavonoid biosynthesis.The abscisic acid,ethylene,jasmonic acid,cytokinins,and brassinosteroids promote flavonoid biosynthesis,while auxin negatively regulates flavonoid biosynthesis.Subsequently,transcription factors from the MYB,bHLH,WRKY,NAC,and bZIP families are pivotal in regulating flavonoid biosynthesis.In addition,non-coding RNAs(microRNA and lncRNA)also participate in the regulation of flavonoids biosynthesis.MicroRNAs are generally believed to negatively regulate flavonoid metabolism in fruits,while lncRNAs have the opposite effect.Furthermore,the interactions between plant hormones,transcription factors,and non-coding RNAs in fruit flavonoid biosynthesis were analyzed.Ultimately,a foundational regulatory network for fruit flavonoid biosynthesis was hereby established.
基金supported by the National Natural Science Foundation of China(32220103006 and 82271524).
文摘Lymphatic vessel networks have been identified in the meninges of mice,non-human primates,and humans[1].Meningeal lymphatic vessels(mLVs),composed of meningeal lymphatic endothelial cells(mLECs),are present in both zebrafish and mammals,although their anatomical distributions differ;they reside in the dura mater in mice,but are situated within the meninges in zebrafish[2].Moreover,the lymphatic marker genes expressed in these vessels differ between species[2].
基金funded by the State Grid Corporation Science and Technology Project(5108-202218280A-2-391-XG).
文摘The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the existing research has not deeply explored the EV active-reactive synergistic regulating characteristics,and failed to realize themulti-timescale synergistic control with other regulatingmeans,For this reason,this paper proposes amultilevel linkage coordinated optimization strategy to reduce the voltage deviation of the distribution network.Firstly,a capacitor bank reactive power compensation voltage control model and a distributed photovoltaic(PV)activereactive power regulationmodel are established.Additionally,an external characteristicmodel of EVactive-reactive power regulation is developed considering the four-quadrant operational characteristics of the EVcharger.Amultiobjective optimization model of the distribution network is then constructed considering the time-series coupling constraints of multiple types of voltage regulators.A multi-timescale control strategy is proposed by considering the impact of voltage regulators on active-reactive EV energy consumption and PV energy consumption.Then,a four-stage voltage control optimization strategy is proposed for various types of voltage regulators with multiple time scales.Themulti-objective optimization is solved with the improvedDrosophila algorithmto realize the power fluctuation control of the distribution network and themulti-stage voltage control optimization.Simulation results validate that the proposed voltage control optimization strategy achieves the coordinated control of decentralized voltage control resources in the distribution network.It effectively reduces the voltage deviation of the distribution network while ensuring the energy demand of EV users and enhancing the stability and economic efficiency of the distribution network.
基金Sponsored by 2025 Postgraduate Teaching Reform Project of North China University of Technology。
文摘Under the dual background of global urbanization and climate change,challenges such as urban waterlogging,degradation of water environment,and fragmentation of biological habitats are intensifying.Advancing the transformation of blue-green infrastructure from a single function to multiple coordinated functions has emerged as a critical path for enhancing urban ecological resilience.The Catharijnesingel Canal Park in Utrecht,the Netherlands,serves as a case study to investigate the synergistic interaction of hydrological regulation and habitat network construction through the transformation of historical canals from grey to blue-green infrastructure.Initially,the implementation path of this“blue-green renaissance”is analyzed,followed by a detailed examination of the spatial realization patterns and mechanisms underlying hydrology and habitat synergy,focusing on river form remodeling,vegetation community alignment,and precise habitat design.The results indicate that the collaborative model of“hydrology and habitat”coupling not only enhances rain-flood resilience,biodiversity,and the quality of public spaces in urban areas but also serves as a reference model for high-density urban regeneration by integrating space,ecology,and efficiency.This model offers both a theoretical foundation and practical guidance for Chinese cities aiming to achieve functional integration and synergistic interaction in ecological restoration and the development of bluegreen spaces.
文摘Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the production line,the manufacturing layer and the workshop layer.The dynamics of re-entrant production lines are governed by hyperbolic partial differential equations(PDEs)based on the law of mass conservation.
基金supported by National Natural Science Foundation of China (Grant No. 50505042)
文摘In the energy regulation based varibable-speed electrohydraulic drive system, the supply energy and the demanded energy, which will affect the control performance greatly, are crucial. However, they are hard to be obtained via conventional methods for some reasons. This paper tries to a new route： the definitive numerical values of the supply energy and the demanded energy are not required, except for their relationship which is called energy state. A three-layer back propagation（BP） neural network was built up to act as an energy analysis unit to deduce the energy state. The neural network has three inputs： the reference displacement, the actual displacement of cylinder rod and the system flowrate supply. The output of the neural network is energy state. A Chebyshev type II filter was designed to calculate the cylinder speed for the estimation of system flowrate supply. The training and testing samples of neural network were collected by the system accurate simulation model. After off-line training, the neural network was tested by the testing data. And the testing result demonstrates that the designed neural network was successful. Then, the neural network acts as the energy analysis unit in real-time experiments of cylinder position control, where it works efficiently under square-wave and sine-wave reference displacement. The experimental results validate its feasibility and adaptability. Only a position sensor and some pressure sensors, which are cheap and have quick dynamic response, are necessary for the system control. And the neural network plays the role of identifying the energy state.
基金the National Natural Science Foundation of China Project:the Study of Central Mechanism of Electroacupuncture on Sishencong (EX-HN1) Improving Sleep Architecture and Neurocognitive Function Using Electroencephalogram-Functional Magnetic Resonance Imaging (No. 81774426)Major Scientific Research Project of Wuxi Health Commission:Clinical Study of Intelligent Hand Rehabilitation Training System for Nerve Function Reconstruction of Patients with Hand Dysfunction after Cerebral Infarction (No. Z202121)。
文摘OBJECTIVE: To analyze part of the mechanism of electroacupuncture on Sishencong(EX-HN1) for strokerelated sleep disorders(SSD) and post-stroke cognitive impairment(PSCI). METHODS: Using a randomized controlled trial(RCT) design, 72 patients were assigned to the electroacupuncture(EA) group or the sham acupuncture(SA) group. A healthy control(HC) group was also included. Both groups were given routine rehabilitation treatment. Then, patients in the EA group were given additional electroacupuncture at Sishencong(EX_HN1). Meanwhile, patients in the SA group were given a flat-head needle sham/placebo treatment placed at the bilateral Jianyu (LI15) and Binao(LI14) line midpoints and the Jianyu(LI15) and Jianzhen(SI9) line midpoints. Before and after treatment, scales were collected and analyzed. In the second phase of the study, some subjects from the EA group were selected for functional magnetic resonance imaging(f MRI) data acquisition and comparative analysis with the HC group using a non-RCT design. RESULTS: The EA group performed better than the SA group on the Pittsburgh sleep quality index(PSQI), Montreal cognitive assessment basic(Mo CA_B), selfrating anxiety scale(SAS), and self-rating depression scale(SDS). Analysis of the f MRI showed that lowfrequency(2 Hz) electroacupuncture stimulation at Sishencong(EX_HN1) can restrain frontal sup medial right(SFGmed.R), precuneus right(PCUN.R), and posterior cingulate cortex right(PCC.R) and enhance angular left(ANG.L), parietal inf left(IPL.L) and occipital mid left(MOG.L). The functional connectivity(FC) of SFGmed.R was positively correlated with PSQI. Electroacupuncture stimulation at Sishencong(EX_HN1) can reduce the side efficiency of the whole brain connection with the Thalamus.L, Hippocampus.L, and Occipital.Mid.L. CONCLUSIONS: Low frequency(2 Hz) electroacupuncture stimulation at Sishencong(EX_HN1) can simultaneously improve sleep quality, negative emotions, and cognitive functions, the first two of which may be related to SFGmed.R restraint. Electroacupuncture can make some brain areas approach the physiological bias state, which is characterized by dominant hemispheric enhancement and non-dominant hemispheric weakening. The reduced whole brain connection side efficiency with some key nodes of the brain net may relate to sleep quality improvements in SSD patients.
基金supported by the National Natural Science Foundation of China(Nos.61973172,62003177,62003175 and 61973175).
文摘The aviation oxygen mask,which has a small volume of less than 1L and strong air tightness,imposes extremely high requirements on control performance of the oxygen regulator.Based on analyses of the operation principle of oxygen supply system,the dynamic model is established through the combination of mechanism analysis and experimental data.Considering that the traditional fixed-parameter controllers are difficult to meet the control requirements with changes in pulmonary ventilation,this paper presents an online feedback controller based on neural network compensation(NNC),with connection weights that can be updated without pre-training.Then mathematical simulations at different respiratory parameters,such as respiratory rate,are performed to verify the superior lower inspiratory resistance of controller with NNC.In terms of hardware,an embedded AI control platform is to complete the experimental verification.Furthermore,the work may have downward compatibility to achieve stable oxygen supply in civil fields,such as medical ventilators,high-altitude expeditions.
基金Supported by National Natural Science Foundation of China,No.82471616,No.82170418,and No.82271618Natural Science Foundation of Hubei Province,No.2022CFA015+2 种基金Central Guiding Local Science and Technology Development Project,No.2022BGE237Key Research and Development Program of Hubei Province,No.2022BCE001,and No.2023BCB139Hubei Provincial Health Commission Project,No.WJ2023M151。
文摘We are deeply interested in the recent findings onβ-arrestin 2.Liu et al demonstrated thatβ-arrestin 2 knockout provides significant protection in diabetic nephropathy,underscoring its potential as a promising therapeutic target for diabetic nephropathy treatment.Furthermore,the role ofβ-arrestin 2 in metabolic regulation is equally critical,particularly in insulin signaling,hepatic glucose production,and adipose tissue function.Althoughβ-arrestin 2 plays a distinct role in metabolism and kidney protection,its tissue-specific regulation opens up valuable avenues for developing targeted therapeutic strategies centered onβ-arrestin 2.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 62266030 and 61863025)。
文摘Regulation plays a pivotal role in mitigating the spread of rumors, serving as a vital tool for maintaining social stability and facilitating its evolution. A central challenge lies in establishing an effective regulatory framework despite limited resources available for combating rumor propagation. To address this challenge, this paper proposes a dynamic and adaptive regulatory system. First, based on observed regulatory patterns in real-world social networks, the rumor propagation process is divided into two distinct phases: regulation and intervention. Regulatory intensity is introduced as an indicator of user state transitions. Unlike traditional, non-adaptive regulatory models that allocate costs uniformly,the adaptive model facilitates flexible cost distribution through a manageable individual regulatory intensity. Moreover,by introducing adaptive strength, the two cost allocation models are integrated within a unified framework, leading to the development of a dynamic model for rumor suppression. Finally, simulation experiments on Barabási–Albert(BA)networks demonstrate that the adaptive regulatory mechanism significantly reduces both the scope and duration of rumor propagation. Furthermore, when traditional non-adaptive regulatory models show limited effectiveness, the adaptive model effectively curbs rumor propagation by optimizing cost allocation between regulatory and intervention processes, and by adjusting per-unit cost benefit differentials.
文摘First, the paper analyzes the advantages and disadvantages of all kinds of reactive power compensation technology, and then proposes a principle and integrated control strategy of the composite operation of TSC and SVG, also the paper designs and develops the main controller of Network based composite power quality regulation device, based on RTDS, the real-time digital simulation model of The Device is established, and finally the prototype of the device is developed with the function of filter and split-phase compensation. The main controller determines the cooperative operation of both TSC and SVG, and the switching strategy of TSC. The simulation result in RTDS can verify the precision of the measure system and the validity of the control logic, the prototype has finished the type test according to the national standard.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11972292,12172291,and 12072265)the 111 Project(Grant No.BP0719007)。
文摘Although the significant roles of magnetic induction and electromagnetic radiation in the neural system have been widely studied,their influence on Parkinson’s disease(PD)has yet to be well explored.By virtue of the magnetic flux variable,this paper studies the transition of firing patterns induced by magnetic induction and the regulation effect of external magnetic radiation on the firing activities of the subthalamopallidal network in basal ganglia.We find:(i)The network reproduces five typical waveforms corresponding to the severity of symptoms:weak cluster,episodic,continuous cluster,episodic,and continuous wave.(ii)Magnetic induction is a double-edged sword for the treatment of PD.Although the increase of magnetic coefficient may lead the physiological firing activity to transfer to pathological firing activity,it also can regulate the pathological intensity firing activity with excessiveβ-band power transferring to the physiological firing pattern with weakβ-band power.(iii)External magnetic radiation could inhibit continuous tremulous firing andβ-band power of subthalamic nucleus(STN),which means the severity of symptoms weakened.Especially,the bi-parameter plane of the regulation region shows that a short pulse period of magnetic radiation and a medium level of pulse percentage can well regulate pathological oscillation.This work helps to understand the firing activity of the subthalamopallidal network under electromagnetic effect.It may also provide insights into the mechanisms behind the electromagnetic therapy of PD-related firing activity.
文摘The advent of the Next Generation Network(NGN),a new service-driven network,urges the telecom service operators to consider transforming from single-service providers to full-service providers.During the transformation,they should be concerned about the network user number and the network quality as well as the value added network information.The low threshold for service provision brings a new breed of service providers,which impacts upon the current regulation policy.To adapt to the development of the NGN,it is a necessity to improve the regulation policy in terms of service operators management,user management,Quality of Service(QoS)assurance,service monitoring,charging,and settlement.Meanwhile,regulatory authorities should establish a new body as quickly as possible to meet the trend of the NGN convergence.The new regulatory body would be responsible for regulating operators who will be awarded full-service licenses,and managing new service providers effectively to guarantee the user’s interests.
文摘With the national electrification level getting higher and higher, peoples dependence on electric energy in production and life is also getting higher and higher. Therefore, people will pay more and more attention to the stable operation of the power system. Electricity is also indispensable to the mechanical work in industry, to all kinds of mechanical work in rural areas, and to all kinds of household appliances in daily life. Therefore, to ensure the stable operation of the urban distribution network can not only meet the needs of peoples lives, but also the inevitable needs of economic and social production development. This paper focuses on the in-depth analysis of the operation and management of the urban distribution network, and also gives some suggestions on the operation and management of the county distribution network.
基金Supported by the National Natural Science Foundation of China (60970114 , 41104010)the National Natural Science Foundation of Hubei Province (ZRZ0041)+2 种基金the Science and Technology Project of Wuhan City (201110921292)the Open Fund of the Ministry of Public Security of the Information Network Security Key Laboratory (C10607)the Independent Scientific Research Projects of the Wuhan University Graduate Student (201121102020002)
文摘In this paper,a dynamic flow-regulation algorithm-oriented network overload control is proposed.It can proportion-ally distribute the load between the high-degree nodes and the low-degree nodes.According to the theoretical analysis,the net-work transmission performance of the proposed algorithm is in inverse proportion to the usage rate of the high-degree nodes.Simulations show that the new algorithm is more flexible and can enhance the network capability in most circumstances compared with the shortest path routing algorithm.Moreover,the compari-son with the efficient routing algorism also reveals the prominent performance of the new algorithm.
文摘Objectives:The current treatment options and therapeutic targets for triple-negative breast cancer(TNBC),an aggressive subtype of breast cancer(BrCA),are limited.This study aimed to identify novel biomarkers and transcriptional regulatory networks(TRN)inherent in TNBC samples.Methods:We analyzed pan-cancer BrCA datasets from The Cancer Genome Atlas(TCGA)to compare triple-positive breast cancer(TPBC)with TNBC.TRN algorithms and virtual inference of protein-enriched regulon(VIPER)were used to identify master regulators and their target genes.Utilizing TNBC cells(MDA-MB-231 and MDA-MB-468),we validated the relationship of nuclear factor erythroid 2-like 3(NFE2L3)and basic helix-loop-helix family member E 40(BHLHE40)by performing a luciferase assay.The expression levels of these targets were measured after transfections with plasmid and siRNA via qRT-PCR and western blots.The effect of these genes on cell proliferation and migration was studied using phenotypic assays.Results:Using computational approaches,we identified NFE2L3 as a master regulator with BHLHE40 as its target gene.NFE2L3 protein binds to the promoter region of BHLHE40 and regulates its transcriptional activity.Additionally,silencing and overexpressing NFE2L3 and BHLHE40 in TNBC cell lines MDA-MB-231 and MDA-MB-468 showed that NFE2L3 directly regulates BHLHE40 at both transcriptional and translational levels.We found that BHLHE40 requires NFE2L3 for cell proliferation and migration in TNBC.Conclusion:These findings underscore the significance of NFE2L3 and BHLHE40 in TNBC,highlighting NFE2L3’s role in regulating the oncogenic activity of BHLHE40 in TNBC cells.
基金Projects(90820302,60805027)supported by the National Natural Science Foundation of ChinaProject(200805330005)supported by the Research Fund for the Doctoral Program of Higher Education,ChinaProject(2009FJ4030)supported by Academician Foundation of Hunan Province,China
文摘Multi-target tracking(MTT) is a research hotspot of wireless sensor networks at present.A self-organized dynamic cluster task allocation scheme is used to implement collaborative task allocation for MTT in WSN and a special cluster member(CM) node selection method is put forward in the scheme.An energy efficiency model was proposed under consideration of both energy consumption and remaining energy balance in the network.A tracking accuracy model based on area-sum principle was also presented through analyzing the localization accuracy of triangulation.Then,the two models mentioned above were combined to establish dynamic cluster member selection model for MTT where a comprehensive performance index function was designed to guide the CM node selection.This selection was fulfilled using genetic algorithm.Simulation results show that this method keeps both energy efficiency and tracking quality in optimal state,and also indicate the validity of genetic algorithm in implementing CM node selection.
基金supported by the National Basic Research Program of China(973 Program),No.2006CB504505,2012CB518504the National Natural Science Foundation of China,No.90709027+1 种基金the Student's Platform for Innovation and Entrepreneurship Training Program of Southern Medical University of China,No.201512121165the Doctoral Foundation of Guangdong Medical University of China,No.2XB13058
文摘The acute effect of acupuncture on Alzheimer's disease,i.e.,on brain activation during treatment,has been reported.However,the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear.Therefore,in this study,we performed long-term needling at Zusanli(ST36)or a sham point(1.5 mm lateral to ST36)in a rat Alzheimer's disease model,for 30 minutes,once per day,for 30 days.The rats underwent 18F-fluorodeoxyglucose positron emission tomography scanning.Positron emission tomography images were processed with SPM2.The brain areas activated after needling at ST36 included the left hippocampus,the left orbital cortex,the left infralimbic cortex,the left olfactory cortex,the left cerebellum and the left pons.In the sham-point group,the activated regions were similar to those in the ST36 group.However,the ST36 group showed greater activation in the cerebellum and pons than the sham-point group.These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer's disease.
