Skin cancer is the abnormal development of cells on the surface of the skin and is one of the most fatal diseases in humans.It usually appears in locations that are exposed to the sun,but can also appear in areas that...Skin cancer is the abnormal development of cells on the surface of the skin and is one of the most fatal diseases in humans.It usually appears in locations that are exposed to the sun,but can also appear in areas that are not regularly exposed to the sun.Due to the striking similarities between benign and malignant lesions,skin cancer detection remains a problem,even for expert dermatologists.Considering the inability of dermatologists to di-agnose skin cancer accurately,a convolutional neural network(CNN)approach was used for skin cancer diag-nosis.However,the CNN model requires a significant number of image datasets for better performance;thus,image augmentation and transfer learning techniques have been used in this study to boost the number of images and the performance of the model,because there are a limited number of medical images.This study proposes an ensemble transfer-learning-based model that can efficiently classify skin lesions into one of seven categories to aid dermatologists in skin cancer detection:(i)actinic keratoses,(ii)basal cell carcinoma,(iii)benign keratosis,(iv)dermatofibroma,(v)melanocytic nevi,(vi)melanoma,and(vii)vascular skin lesions.Five transfer learning models were used as the basis of the ensemble:MobileNet,EfficientNetV2B2,Xception,ResNeXt101,and Den-seNet201.In addition to the stratified 10-fold cross-validation,the results of each individual model were fused to achieve greater classification accuracy.An annealing learning rate scheduler and test time augmentation(TTA)were also used to increase the performance of the model during the training and testing stages.A total of 10,015 publicly available dermoscopy images from the HAM10000(Human Against Machine)dataset,which contained samples from the seven common skin lesion categories,were used to train and evaluate the models.The proposed technique attained 94.49%accuracy on the dataset.These results suggest that this strategy can be useful for improving the accuracy of skin cancer classification.However,the weighted average of F1-score,recall,and precision were obtained to be 94.68%,94.49%,and 95.07%,respectively.展开更多
The reaction rate constant is a crucial kinetic parameter that governs the charge and discharge performance of batteries,particularly in high-rate and thick-electrode applications.However,conventional estimation or fi...The reaction rate constant is a crucial kinetic parameter that governs the charge and discharge performance of batteries,particularly in high-rate and thick-electrode applications.However,conventional estimation or fitting methods often overestimate the charge transfer overpotential,leading to substantial errors in reaction rate constant measurements.These inaccuracies hinder the accurate prediction of voltage profiles and overall cell performance.In this study,we propose the characteristic time-decomposed overpotential(CTDO)method,which employs a single-layer particle electrode(SLPE)structure to eliminate interference overpotentials.By leveraging the distribution of relaxation times(DRT),our method effectively isolates the characteristic time of the charge transfer process,enabling a more precise determination of the reaction rate constant.Simulation results indicate that our approach reduces measurement errors to below 2%,closely aligning with theoretical values.Furthermore,experimental validation demonstrates an 80% reduction in error compared to the conventional galvanostatic intermittent titration technique(GITT)method.Overall,this study provides a novel voltage-based approach for determining the reaction rate constant,enhancing the applicability of theoretical analysis in electrode structural design and facilitating rapid battery optimization.展开更多
Transferring patients with critical illnesses from general wards to intensive care units (ICUs) is a crucial and time-sensitive process. This article presents strategies for improving the efficiency of patient transfe...Transferring patients with critical illnesses from general wards to intensive care units (ICUs) is a crucial and time-sensitive process. This article presents strategies for improving the efficiency of patient transfers, particularly in hospitals where intensive care units are located in buildings separate from general wards. Patient transfers comprise several steps: physicians issue orders, relatives are notified, equipment is prepared, and medical staff coordinate. We identified three factors that influence transfer time: preparation time for bed transfer, time required for shift handovers, and time required for between-ward patient movement. Unfamiliarity with transfer routes and long elevator wait times were factors that also influenced transfer time. The following strategies were proposed: develop a standardized material checklist, design key notes for patient transfers, and optimize transfer routes. These strategies reduced transfer times by 40% to 43%. This study demonstrates that by addressing logistical challenges and streamlining relevant procedures, hospitals can enhance safety and quality of care during patient transfers.展开更多
The exfoliation corrosion （EFC） behavior of 7050-T6 aluminum alloy treated with various quench transfer time after solution heat treatment was investigated by standard EFC immersion tests, strength loss measurements...The exfoliation corrosion （EFC） behavior of 7050-T6 aluminum alloy treated with various quench transfer time after solution heat treatment was investigated by standard EFC immersion tests, strength loss measurements after EFC tests and electrochemical impedance spectroscope （EIS） technique. The results showed that EFC resistance of the alloy decreased with increasing quench transfer time. Backscattered electron scanning electron microscope （SEM） together with transmission electron microscope （TEM） observations revealed that the coverage ratio and microstructure of precipitates at grain boundary area are the most important factors which influence the EFC susceptibility of the alloy, while precipitate-free zone （PFZ） near grain boundary has no or only a minor effect on it. In addition, galvanostatic measurements of the alloy present a good correlation between EFC resistance and transients in potential. The cumulated number of transients in potential can be used to evaluate EFC resistance of the alloy.展开更多
[Objective] The study aimed to provide references for the time of oocyte maturation in vitro and enucleation in the course of sheep nuclear transfer(NT).[Method] Compared the effects of different maturation time of oo...[Objective] The study aimed to provide references for the time of oocyte maturation in vitro and enucleation in the course of sheep nuclear transfer(NT).[Method] Compared the effects of different maturation time of oocytes on enucleation efficiency and reconstructed embryo development by means of blind enucleation and fluorescence microscopy.[Result] Treatment of IVM(in vitro maturation)19-21 h was significantly higher than IVM 16-18 h treatment in oocyte maturation rate(P<0.05)and was significantly higher than IVM 22-24 h treatment in enucleation rate(P<0.05).Three treatments had no significant difference in cleavage rate and blastocyst rate(P>0.05),but IVM 19-21 h treatment was significantly higher than the other 2 treatments in average cell number of blastocysts(P<0.05).[Conclusion] The appropriate in vitro maturation time of oocytes was 19-21 h for sheep nuclear transfer,which could significantly improve the quality of blastocysts according to the cell number per blastocyst(P<0.05).展开更多
Lot scheduling problem with idle time transfer between processes to minimize mean flow time is very important because to minimize mean flow time is to minimize work in process. But the problem is NP hard and no polyn...Lot scheduling problem with idle time transfer between processes to minimize mean flow time is very important because to minimize mean flow time is to minimize work in process. But the problem is NP hard and no polynomial algorithm exists to guarantee optimal solution. Based the analysis the mathematical structure of the problem, the paper presents a new heuristic algorithm. Computer simulation shows that the proposed heuristic algorithm performs well in terms of both quality of solution and execution speed.展开更多
In this paper, by defining new state vectors and developing new transfer matrices of various elements mov- ing in space, the discrete time transfer matrix method of multi-rigid-flexible-body system is expanded to stud...In this paper, by defining new state vectors and developing new transfer matrices of various elements mov- ing in space, the discrete time transfer matrix method of multi-rigid-flexible-body system is expanded to study the dynamics of multibody system with flexible beams moving in space. Formulations and numerical example of a rigid- flexible-body three pendulums system moving in space are given to validate the method. Using the new method to study the dynamics of multi-rigid-flexible-body system mov- ing in space, the global dynamics equations of system are not needed, the orders of involved matrices of the system are very low and the computational speed is high, irrespec- tive of the size of the system. The new method is simple, straightforward, practical, and provides a powerful tool for multi-rigid-flexible-body system dynamics.展开更多
A system of jointly transferring time signals with a rate of 1 pulse per second （PPS） and frequency signals of 10 MHz via a dense wavelength division multiplex-based （DWDM） fiber is demonstrated in this paper. The...A system of jointly transferring time signals with a rate of 1 pulse per second （PPS） and frequency signals of 10 MHz via a dense wavelength division multiplex-based （DWDM） fiber is demonstrated in this paper. The noises of the fiber links are suppressed and compensated for by a controlled fiber delay line. A method of calibrating and characterizing time is described. The 1PPS is synchronized by feed-forward calibrating the fiber delays precisely. The system is experimen- tally examined via a 110 km spooled fiber in laboratory. The frequency stabilities of the user end with compensation are 1.8x 10-14 at 1 s and 2.0x 10-17 at 104 s average time. The calculated uncertainty of time synchronization is 13.1 ps, whereas the direct measurement of the uncertainty is 12 ps. Next, the frequency and 1PPS are transferred via a metropoli- tan area optical fiber network from one central site to two remote sites with distances of 14 km and 110 km. The frequency stabilities of 14 km link reach 3.0x 10-14 averaged in 1 s and 1.4x 10-17 in 104 s respectively; and the stabilities of 110 km link are 8.3 x 10-14 and 1.7 x 10-17, respectively. The accuracies of synchronization are estimated to be 12.3 ps for the 14 km link and 13.1 ps for the 110 km link, respectively.展开更多
Three functional models, polynomial, spectral analysis, and modified AR model, are studied and compared in fitting and predicting clock deviation based on the data sequence derived from two-way satellite time and freq...Three functional models, polynomial, spectral analysis, and modified AR model, are studied and compared in fitting and predicting clock deviation based on the data sequence derived from two-way satellite time and frequency transfer. A robust equivalent weight is applied, which controls the significant influence of outlying observations. Some conclusions show that the prediction precision of robust estimation is better than that of LS. The prediction precision calculated from smoothed observations is higher than that calculated from sampling observations. As a count of the obvious period variations in the clock deviation sequence, the predicted values of polynomial model are implausible. The prediction precision of spectral analysis model is very low, but the principal periods can be determined. The prediction RMS of 6-hour extrapolation interval is Ins or so, when modified AR model is used.展开更多
In the big data environment, enterprises must constantly assimilate big dataknowledge and private knowledge by multiple knowledge transfers to maintain theircompetitive advantage. The optimal time of knowledge transfe...In the big data environment, enterprises must constantly assimilate big dataknowledge and private knowledge by multiple knowledge transfers to maintain theircompetitive advantage. The optimal time of knowledge transfer is one of the mostimportant aspects to improve knowledge transfer efficiency. Based on the analysis of thecomplex characteristics of knowledge transfer in the big data environment, multipleknowledge transfers can be divided into two categories. One is the simultaneous transferof various types of knowledge, and the other one is multiple knowledge transfers atdifferent time points. Taking into consideration the influential factors, such as theknowledge type, knowledge structure, knowledge absorptive capacity, knowledge updaterate, discount rate, market share, profit contributions of each type of knowledge, transfercosts, product life cycle and so on, time optimization models of multiple knowledgetransfers in the big data environment are presented by maximizing the total discountedexpected profits (DEPs) of an enterprise. Some simulation experiments have beenperformed to verify the validity of the models, and the models can help enterprisesdetermine the optimal time of multiple knowledge transfer in the big data environment.展开更多
The influence of quench transfer time on the microstructure and mechanical properties of 7055 aluminum alloy with and without zirconium was investigated by tensile properties test,optical microscopy,scanning electron ...The influence of quench transfer time on the microstructure and mechanical properties of 7055 aluminum alloy with and without zirconium was investigated by tensile properties test,optical microscopy,scanning electron microscopy and transmission electron microscopy.For the Zr-free alloy,the strength increases to the highest value at 20 s with transfer time,and then decreases slightly.The elongation decreases slowly with transfer time within 20 s,and more rapidly after 20 s.For the Zr-containing alloy,prolonging transfer time within 20 s results in slight decrease in the strength and elongation,and rapid drop of which is observed after 20 s.For the Zr-free alloy,prolonging transfer time can increase the percentage of intergranular fracture,which is mainly caused by wide grain boundary precipitate free zone.The failure mode of the Zr-containing alloy is modified from the predominant transgranular void growth and intergranular fracture to transgranular shear and intergranular fracture with increase in the transfer time,which is attributed to the wider grain boundary precipitate free zone and coarse equilibrium η phases in the matrix.展开更多
Efficient real time data exchange over the Internet plays a crucial role in the successful application of web-based systems. In this paper, a data transfer mechanism over the Internet is proposed for real time web bas...Efficient real time data exchange over the Internet plays a crucial role in the successful application of web-based systems. In this paper, a data transfer mechanism over the Internet is proposed for real time web based applications. The mechanism incorporates the eXtensible Markup Language （XML） and Hierarchical Data Format （HDF） to provide a flexible and efficient data format. Heterogeneous transfer data is classified into light and heavy data, which are stored using XML and HDF respectively; the HDF data format is then mapped to Java Document Object Model （JDOM） objects in XML in the Java environment. These JDOM data objects are sent across computer networks with the support of the Java Remote Method Invocation （RMI） data transfer infrastructure. Client＇s defined data priority levels are implemented in RMI, which guides a server to transfer data objects at different priorities. A remote monitoring system for an industrial reactor process simulator is used as a case study to illustrate the proposed data transfer mechanism.展开更多
Two methods for smoothing pseudorange observable by Carrier and Doppler are discussed.Then the procedure based on the RINEX observation files is tested using the Ashtech Z-XII3T geodetic receivers driven by a stable e...Two methods for smoothing pseudorange observable by Carrier and Doppler are discussed.Then the procedure based on the RINEX observation files is tested using the Ashtech Z-XII3T geodetic receivers driven by a stable external frequency at UNSO.This paper proposes to adapt this procedure for the links between geodetic receivers,in order to take advantage of the P codes available on L 1 and L 2.This new procedure uses the 30-second RINEX observations files,the standard of the International GPS Service(IGS),and processes the ionosphere-free combination of the codes P 1 and P 2;the satellite positions are deduced from the IGS rapid orbits,available after two days.展开更多
A millimeter scale butterfly-shaped reactor was proposed based on sizing-up strategy and fabricated via femtosecond laser engraving. An improvement of mixing performance and residence time distribution was realized by...A millimeter scale butterfly-shaped reactor was proposed based on sizing-up strategy and fabricated via femtosecond laser engraving. An improvement of mixing performance and residence time distribution was realized by means of contraction and expansion of the reaction channel. The liquid holdup was greatly increased through connection of multiple mixing units. Structure optimization of the reactor was carried out by computational fluid dynamics simulation, from which the effect of reactor internals on mixing and the influence of parallel branching structure on heat transfer were discussed. The UV–vis absorption spectroscopy was used to determine the residence time distribution in the reactor, and characteristic parameters such as skewness and dimensionless variance were obtained. Further, a chained stagnant flow model was proposed to precisely describe the trailing phenomenon caused by fluid stagnation and laminar flow in small scale reactors, which enables a better fit for the experimental results of the asymmetric residence time distribution. In addition, the heat transfer performance of the reactor was investigated, and the overall heat transfer coefficient was 110–600 W m^(-2)K-1in the flow rate range of 10–40 m L/min.展开更多
Background Key performance indices such as door-to-balloon times have long been recognized as quality metrics in reducing time to care for patients with acute coronary syndromes(ACS). In the situation where patients d...Background Key performance indices such as door-to-balloon times have long been recognized as quality metrics in reducing time to care for patients with acute coronary syndromes(ACS). In the situation where patients do not present to a facility capable of 24/7 percutaneous coronary interventions(PCI) delays in time to therapy can exceed the recommendation of 90 min or less. This study aimed to evaluate the impact of transfers on performance indices for patients diagnosed with ST-segment elevation myocardial infarction(STEMI). Methods Over a seven month collection period, all patients presenting with symptoms suggestive of ACS and admitted for PCI were studied. Patients were divided into dichotomous groups of direct presentations or transfers from a secondary non-PCI capable hospital with key times recorded, including symptom-onset, first hospital and PCI-capable hospital arrival and balloon inflation times to evaluate time of treatment for STEMI patients. Results Of the 87 patients diagnosed with STEMI, transferred patients experienced statistically significant delays in symptom-onset to the PCI-capable hospital(PCI-H) arrival(215 vs. 95 min, P < 0.001), symptom-onset to balloon inflation(225 vs. 160 min, P = 0.009) and first hospital arrival to balloon inflation times(106 vs. 56 min, P < 0.001). Only 28%(n = 9) of transferred patients underwent balloon inflation within 90 min from first hospital arrival, while 60%(n = 19) did within 120 min, although all received balloon inflation within 90 min from arrival at the PCI-H. After controlling for confounding factors of socio-economic status, presentation date/time and diagnostic category, transferred patients experienced an average 162% longer delays from symptom-onset to PCI-H door arrival, and 98% longer delays in symptom-onset to balloon inflation;compared to patients who present directly to the PCI-H. No statistically significant differences were noted between transferred and direct patients when measured from PCI-H door-to-balloon times. Conclusions This study shows that transferred patients experience a greater overall system delay, compared to patients who present directly for PCI, significantly increasing their time to treatment and therefore infarct times. Despite the majority of transfers experiencing pre-hospital activation, their treatment hospital arrival to balloon times are no less than direct presenters after controlling for confounding factors, further compounding the overall delay to therapy.展开更多
High-precision time transfer plays an important role in the areas of fundamental research and applications. Accompanying w ith the remarkable improvements in the ability of generating and measuring high-accuracy time-...High-precision time transfer plays an important role in the areas of fundamental research and applications. Accompanying w ith the remarkable improvements in the ability of generating and measuring high-accuracy time-frequency signal,seeking for new time-transfer techniques betw een distant clocks w ith much further improved accuracy attracts attentions w orld-w idely. The time-transfer technique based on optical pulses has the highest precision presently,and the further improvement in the accuracy is heavily dependent on the time-domain properties of the pulse as w ell as the sensitivity of the applied measurement on the exchanged pulse. The application of optical frequency comb in time transfer for a precision up to femtosecond level are currently the focus of much interest,and has recently achieved many breakthroughs. Further investigations show that,utilizing quantum techniques,i.e. quantum measurement technique and quantum optical pulse source,can lead to a new limit on the measured timing information. Furthermore,it can be immune from atmospheric parameters,such as pressure,temperature,humidity and so on.Such quantum improvements on time-transfer have a bright prospect in the future applications requiring extremely high-accuracy timing and ranging. The potential achievements w ill form a technical basis for the future realization of sub-femtosecond time transfer system.展开更多
Correlations between two time series,including the linear Pearson correlation and the nonlinear transfer entropy,have attracted significant attention.In this work,we studied the correlations between multiple stock dat...Correlations between two time series,including the linear Pearson correlation and the nonlinear transfer entropy,have attracted significant attention.In this work,we studied the correlations between multiple stock data with the introduction of a time delay and a rolling window.In most cases,the Pearson correlation and transfer entropy share the same tendency,where a higher correlation provides more information for predicting future trends from one stock to another,but a lower correlation provides less.Considering the computational complexity of the transfer entropy and the simplicity of the Pearson correlation,using the linear correlation with time delays and a rolling window is a robust and simple method to quantify the mutual information between stocks.Predictions made by the long short-term memory method with mutual information outperform those made only with selfinformation when there are high correlations between two stocks.展开更多
A self-adaptive precise algorithm in the time domain was employed to solve 2-D nonlinear coupled heat and moisture transfer problems. By expanding variables at a discretized time interval, the variations of variables ...A self-adaptive precise algorithm in the time domain was employed to solve 2-D nonlinear coupled heat and moisture transfer problems. By expanding variables at a discretized time interval, the variations of variables can be described more precisely,and a nonlinear coupled initial and boundary value problem was converted into a series of recurrent linear boundary value problems which are solved by FE technique. In the computation, no additional assumption and the nonlinear iteration are required, and a criterion for self-adaptive computation is proposed to maintain sufficient computing accuracy for the change sizes of time steps. In the numerical comparison, the variations of material properties with temperature, moisture content, and both temperature and moisture content are taken into account, respectively. Satisfactory results have been obtained, indicating that the proposed approach is capable of dealing with complex nonlinear problems.展开更多
Objective:To explore the effect of different fertilization time after human chorionic gonadotropin(HCG)injection on the outcome of fertilization in vitro fertilization-embryo transfer(IVF-ET).Methods:One thousand one ...Objective:To explore the effect of different fertilization time after human chorionic gonadotropin(HCG)injection on the outcome of fertilization in vitro fertilization-embryo transfer(IVF-ET).Methods:One thousand one hundred and forty IVF-ET cycles from January 2016 to August 2018 were analyzed retrospectively.According to the different fertilization time after injection of HCG divided into four groups:Group A(38.0 h~39.0 h),Group B(39.1 h~40.0 h),Group C(40.1 h~41.0 h),and Group D(41.1 h~42.0 h).The normal fertilization rate,the normal cleavage rate,the embryo utilization rate,the high-quality embryo rate,the clinical pregnancy rate,the implantation rate,and the spontaneous abortion rate were analyzed among the groups.Then we investigated the effect of different promotion methods on the outcome of fertilization during the optimal fertilization time.Results:There was no significant difference in 2PN cleavage rate,available embryo rate,clinical pregnancy rate,implantation rate and abortion rate among the four groups(P>0.05).The high-quality embryo rate in Group D(44.6%)was the highest,and was significantly different among the four groups(P<0.05).The normal fertilization rate in Group D(71.6%)was the highest,and was significantly different among the four groups(P<0.05).The normal fertilization rate(78.1%)of antagonist group was significantly higher than other groups(P<0.05).Conclusion:The different fertilization time after HCG injection have effects on high-quality embryo rate and normal fertilization rate of patients in IVF-ET.The appropriate fertilization time of patients in IVF-ET was 41 h~42 h after HCG injection in our reproductive center,improved the clinical pregnancy rate and reduced the early abortion rate.The GnRH-ant protocol is superior to other protocol in IVF-ET.展开更多
文摘Skin cancer is the abnormal development of cells on the surface of the skin and is one of the most fatal diseases in humans.It usually appears in locations that are exposed to the sun,but can also appear in areas that are not regularly exposed to the sun.Due to the striking similarities between benign and malignant lesions,skin cancer detection remains a problem,even for expert dermatologists.Considering the inability of dermatologists to di-agnose skin cancer accurately,a convolutional neural network(CNN)approach was used for skin cancer diag-nosis.However,the CNN model requires a significant number of image datasets for better performance;thus,image augmentation and transfer learning techniques have been used in this study to boost the number of images and the performance of the model,because there are a limited number of medical images.This study proposes an ensemble transfer-learning-based model that can efficiently classify skin lesions into one of seven categories to aid dermatologists in skin cancer detection:(i)actinic keratoses,(ii)basal cell carcinoma,(iii)benign keratosis,(iv)dermatofibroma,(v)melanocytic nevi,(vi)melanoma,and(vii)vascular skin lesions.Five transfer learning models were used as the basis of the ensemble:MobileNet,EfficientNetV2B2,Xception,ResNeXt101,and Den-seNet201.In addition to the stratified 10-fold cross-validation,the results of each individual model were fused to achieve greater classification accuracy.An annealing learning rate scheduler and test time augmentation(TTA)were also used to increase the performance of the model during the training and testing stages.A total of 10,015 publicly available dermoscopy images from the HAM10000(Human Against Machine)dataset,which contained samples from the seven common skin lesion categories,were used to train and evaluate the models.The proposed technique attained 94.49%accuracy on the dataset.These results suggest that this strategy can be useful for improving the accuracy of skin cancer classification.However,the weighted average of F1-score,recall,and precision were obtained to be 94.68%,94.49%,and 95.07%,respectively.
基金supported by the National Key R&D Program of China 2022YFB2404300the National Natural Science Foundation of China U22B2069the China Postdoctoral Science Foundation 2024M761006。
文摘The reaction rate constant is a crucial kinetic parameter that governs the charge and discharge performance of batteries,particularly in high-rate and thick-electrode applications.However,conventional estimation or fitting methods often overestimate the charge transfer overpotential,leading to substantial errors in reaction rate constant measurements.These inaccuracies hinder the accurate prediction of voltage profiles and overall cell performance.In this study,we propose the characteristic time-decomposed overpotential(CTDO)method,which employs a single-layer particle electrode(SLPE)structure to eliminate interference overpotentials.By leveraging the distribution of relaxation times(DRT),our method effectively isolates the characteristic time of the charge transfer process,enabling a more precise determination of the reaction rate constant.Simulation results indicate that our approach reduces measurement errors to below 2%,closely aligning with theoretical values.Furthermore,experimental validation demonstrates an 80% reduction in error compared to the conventional galvanostatic intermittent titration technique(GITT)method.Overall,this study provides a novel voltage-based approach for determining the reaction rate constant,enhancing the applicability of theoretical analysis in electrode structural design and facilitating rapid battery optimization.
文摘Transferring patients with critical illnesses from general wards to intensive care units (ICUs) is a crucial and time-sensitive process. This article presents strategies for improving the efficiency of patient transfers, particularly in hospitals where intensive care units are located in buildings separate from general wards. Patient transfers comprise several steps: physicians issue orders, relatives are notified, equipment is prepared, and medical staff coordinate. We identified three factors that influence transfer time: preparation time for bed transfer, time required for shift handovers, and time required for between-ward patient movement. Unfamiliarity with transfer routes and long elevator wait times were factors that also influenced transfer time. The following strategies were proposed: develop a standardized material checklist, design key notes for patient transfers, and optimize transfer routes. These strategies reduced transfer times by 40% to 43%. This study demonstrates that by addressing logistical challenges and streamlining relevant procedures, hospitals can enhance safety and quality of care during patient transfers.
基金Project(2012CB619502)supported by the National Basic Research Program of China
文摘The exfoliation corrosion （EFC） behavior of 7050-T6 aluminum alloy treated with various quench transfer time after solution heat treatment was investigated by standard EFC immersion tests, strength loss measurements after EFC tests and electrochemical impedance spectroscope （EIS） technique. The results showed that EFC resistance of the alloy decreased with increasing quench transfer time. Backscattered electron scanning electron microscope （SEM） together with transmission electron microscope （TEM） observations revealed that the coverage ratio and microstructure of precipitates at grain boundary area are the most important factors which influence the EFC susceptibility of the alloy, while precipitate-free zone （PFZ） near grain boundary has no or only a minor effect on it. In addition, galvanostatic measurements of the alloy present a good correlation between EFC resistance and transients in potential. The cumulated number of transients in potential can be used to evaluate EFC resistance of the alloy.
基金Supported by School Program of Henan Institute of Science and Technology(20060516)~~
文摘[Objective] The study aimed to provide references for the time of oocyte maturation in vitro and enucleation in the course of sheep nuclear transfer(NT).[Method] Compared the effects of different maturation time of oocytes on enucleation efficiency and reconstructed embryo development by means of blind enucleation and fluorescence microscopy.[Result] Treatment of IVM(in vitro maturation)19-21 h was significantly higher than IVM 16-18 h treatment in oocyte maturation rate(P<0.05)and was significantly higher than IVM 22-24 h treatment in enucleation rate(P<0.05).Three treatments had no significant difference in cleavage rate and blastocyst rate(P>0.05),but IVM 19-21 h treatment was significantly higher than the other 2 treatments in average cell number of blastocysts(P<0.05).[Conclusion] The appropriate in vitro maturation time of oocytes was 19-21 h for sheep nuclear transfer,which could significantly improve the quality of blastocysts according to the cell number per blastocyst(P<0.05).
文摘Lot scheduling problem with idle time transfer between processes to minimize mean flow time is very important because to minimize mean flow time is to minimize work in process. But the problem is NP hard and no polynomial algorithm exists to guarantee optimal solution. Based the analysis the mathematical structure of the problem, the paper presents a new heuristic algorithm. Computer simulation shows that the proposed heuristic algorithm performs well in terms of both quality of solution and execution speed.
基金supported by the Natural Science Foundation of China Government (10902051)the Natural Science Foundation of Jiangsu Province (BK2008046)the German Science Foundation
文摘In this paper, by defining new state vectors and developing new transfer matrices of various elements mov- ing in space, the discrete time transfer matrix method of multi-rigid-flexible-body system is expanded to study the dynamics of multibody system with flexible beams moving in space. Formulations and numerical example of a rigid- flexible-body three pendulums system moving in space are given to validate the method. Using the new method to study the dynamics of multi-rigid-flexible-body system mov- ing in space, the global dynamics equations of system are not needed, the orders of involved matrices of the system are very low and the computational speed is high, irrespec- tive of the size of the system. The new method is simple, straightforward, practical, and provides a powerful tool for multi-rigid-flexible-body system dynamics.
基金supported by the National Natural Science Foundation of China(Grant No.61405227)
文摘A system of jointly transferring time signals with a rate of 1 pulse per second （PPS） and frequency signals of 10 MHz via a dense wavelength division multiplex-based （DWDM） fiber is demonstrated in this paper. The noises of the fiber links are suppressed and compensated for by a controlled fiber delay line. A method of calibrating and characterizing time is described. The 1PPS is synchronized by feed-forward calibrating the fiber delays precisely. The system is experimen- tally examined via a 110 km spooled fiber in laboratory. The frequency stabilities of the user end with compensation are 1.8x 10-14 at 1 s and 2.0x 10-17 at 104 s average time. The calculated uncertainty of time synchronization is 13.1 ps, whereas the direct measurement of the uncertainty is 12 ps. Next, the frequency and 1PPS are transferred via a metropoli- tan area optical fiber network from one central site to two remote sites with distances of 14 km and 110 km. The frequency stabilities of 14 km link reach 3.0x 10-14 averaged in 1 s and 1.4x 10-17 in 104 s respectively; and the stabilities of 110 km link are 8.3 x 10-14 and 1.7 x 10-17, respectively. The accuracies of synchronization are estimated to be 12.3 ps for the 14 km link and 13.1 ps for the 110 km link, respectively.
基金Supported by the National Natural Science Foundations of China （No. 40474001, No. 40274002, No. 40604003）.
文摘Three functional models, polynomial, spectral analysis, and modified AR model, are studied and compared in fitting and predicting clock deviation based on the data sequence derived from two-way satellite time and frequency transfer. A robust equivalent weight is applied, which controls the significant influence of outlying observations. Some conclusions show that the prediction precision of robust estimation is better than that of LS. The prediction precision calculated from smoothed observations is higher than that calculated from sampling observations. As a count of the obvious period variations in the clock deviation sequence, the predicted values of polynomial model are implausible. The prediction precision of spectral analysis model is very low, but the principal periods can be determined. The prediction RMS of 6-hour extrapolation interval is Ins or so, when modified AR model is used.
基金supported by the National Natural Science Foundation ofChina (Grant No. 71704016,71331008, 71402010)the Natural Science Foundation of HunanProvince (Grant No. 2017JJ2267)+1 种基金the Educational Economy and Financial Research Base ofHunan Province (Grant No. 13JCJA2)the Project of China Scholarship Council forOverseas Studies (201508430121, 201208430233).
文摘In the big data environment, enterprises must constantly assimilate big dataknowledge and private knowledge by multiple knowledge transfers to maintain theircompetitive advantage. The optimal time of knowledge transfer is one of the mostimportant aspects to improve knowledge transfer efficiency. Based on the analysis of thecomplex characteristics of knowledge transfer in the big data environment, multipleknowledge transfers can be divided into two categories. One is the simultaneous transferof various types of knowledge, and the other one is multiple knowledge transfers atdifferent time points. Taking into consideration the influential factors, such as theknowledge type, knowledge structure, knowledge absorptive capacity, knowledge updaterate, discount rate, market share, profit contributions of each type of knowledge, transfercosts, product life cycle and so on, time optimization models of multiple knowledgetransfers in the big data environment are presented by maximizing the total discountedexpected profits (DEPs) of an enterprise. Some simulation experiments have beenperformed to verify the validity of the models, and the models can help enterprisesdetermine the optimal time of multiple knowledge transfer in the big data environment.
基金Project(2005CB623706) supported by the Major State Basic Research Development Program of ChinaProject(50230310) supported by the National Natural Science Foundation of China
文摘The influence of quench transfer time on the microstructure and mechanical properties of 7055 aluminum alloy with and without zirconium was investigated by tensile properties test,optical microscopy,scanning electron microscopy and transmission electron microscopy.For the Zr-free alloy,the strength increases to the highest value at 20 s with transfer time,and then decreases slightly.The elongation decreases slowly with transfer time within 20 s,and more rapidly after 20 s.For the Zr-containing alloy,prolonging transfer time within 20 s results in slight decrease in the strength and elongation,and rapid drop of which is observed after 20 s.For the Zr-free alloy,prolonging transfer time can increase the percentage of intergranular fracture,which is mainly caused by wide grain boundary precipitate free zone.The failure mode of the Zr-containing alloy is modified from the predominant transgranular void growth and intergranular fracture to transgranular shear and intergranular fracture with increase in the transfer time,which is attributed to the wider grain boundary precipitate free zone and coarse equilibrium η phases in the matrix.
文摘Efficient real time data exchange over the Internet plays a crucial role in the successful application of web-based systems. In this paper, a data transfer mechanism over the Internet is proposed for real time web based applications. The mechanism incorporates the eXtensible Markup Language （XML） and Hierarchical Data Format （HDF） to provide a flexible and efficient data format. Heterogeneous transfer data is classified into light and heavy data, which are stored using XML and HDF respectively; the HDF data format is then mapped to Java Document Object Model （JDOM） objects in XML in the Java environment. These JDOM data objects are sent across computer networks with the support of the Java Remote Method Invocation （RMI） data transfer infrastructure. Client＇s defined data priority levels are implemented in RMI, which guides a server to transfer data objects at different priorities. A remote monitoring system for an industrial reactor process simulator is used as a case study to illustrate the proposed data transfer mechanism.
基金Funded by the Key Laboratory of Geospace Environment and Geodesy,Ministry of Education,China(No.02090.5)the National Natural ScienceFoundation of China(No.40174005).
文摘Two methods for smoothing pseudorange observable by Carrier and Doppler are discussed.Then the procedure based on the RINEX observation files is tested using the Ashtech Z-XII3T geodetic receivers driven by a stable external frequency at UNSO.This paper proposes to adapt this procedure for the links between geodetic receivers,in order to take advantage of the P codes available on L 1 and L 2.This new procedure uses the 30-second RINEX observations files,the standard of the International GPS Service(IGS),and processes the ionosphere-free combination of the codes P 1 and P 2;the satellite positions are deduced from the IGS rapid orbits,available after two days.
基金funded by the National Natural Science Foundation of China (Nos. 21991103, 21991104, 22008074, 22008072)Natural Science Foundation of Shanghai (No. 20ZR1415700)China Postdoctoral Science Foundation (Nos. 2020M671025,2019TQ0093)。
文摘A millimeter scale butterfly-shaped reactor was proposed based on sizing-up strategy and fabricated via femtosecond laser engraving. An improvement of mixing performance and residence time distribution was realized by means of contraction and expansion of the reaction channel. The liquid holdup was greatly increased through connection of multiple mixing units. Structure optimization of the reactor was carried out by computational fluid dynamics simulation, from which the effect of reactor internals on mixing and the influence of parallel branching structure on heat transfer were discussed. The UV–vis absorption spectroscopy was used to determine the residence time distribution in the reactor, and characteristic parameters such as skewness and dimensionless variance were obtained. Further, a chained stagnant flow model was proposed to precisely describe the trailing phenomenon caused by fluid stagnation and laminar flow in small scale reactors, which enables a better fit for the experimental results of the asymmetric residence time distribution. In addition, the heat transfer performance of the reactor was investigated, and the overall heat transfer coefficient was 110–600 W m^(-2)K-1in the flow rate range of 10–40 m L/min.
文摘Background Key performance indices such as door-to-balloon times have long been recognized as quality metrics in reducing time to care for patients with acute coronary syndromes(ACS). In the situation where patients do not present to a facility capable of 24/7 percutaneous coronary interventions(PCI) delays in time to therapy can exceed the recommendation of 90 min or less. This study aimed to evaluate the impact of transfers on performance indices for patients diagnosed with ST-segment elevation myocardial infarction(STEMI). Methods Over a seven month collection period, all patients presenting with symptoms suggestive of ACS and admitted for PCI were studied. Patients were divided into dichotomous groups of direct presentations or transfers from a secondary non-PCI capable hospital with key times recorded, including symptom-onset, first hospital and PCI-capable hospital arrival and balloon inflation times to evaluate time of treatment for STEMI patients. Results Of the 87 patients diagnosed with STEMI, transferred patients experienced statistically significant delays in symptom-onset to the PCI-capable hospital(PCI-H) arrival(215 vs. 95 min, P < 0.001), symptom-onset to balloon inflation(225 vs. 160 min, P = 0.009) and first hospital arrival to balloon inflation times(106 vs. 56 min, P < 0.001). Only 28%(n = 9) of transferred patients underwent balloon inflation within 90 min from first hospital arrival, while 60%(n = 19) did within 120 min, although all received balloon inflation within 90 min from arrival at the PCI-H. After controlling for confounding factors of socio-economic status, presentation date/time and diagnostic category, transferred patients experienced an average 162% longer delays from symptom-onset to PCI-H door arrival, and 98% longer delays in symptom-onset to balloon inflation;compared to patients who present directly to the PCI-H. No statistically significant differences were noted between transferred and direct patients when measured from PCI-H door-to-balloon times. Conclusions This study shows that transferred patients experience a greater overall system delay, compared to patients who present directly for PCI, significantly increasing their time to treatment and therefore infarct times. Despite the majority of transfers experiencing pre-hospital activation, their treatment hospital arrival to balloon times are no less than direct presenters after controlling for confounding factors, further compounding the overall delay to therapy.
文摘High-precision time transfer plays an important role in the areas of fundamental research and applications. Accompanying w ith the remarkable improvements in the ability of generating and measuring high-accuracy time-frequency signal,seeking for new time-transfer techniques betw een distant clocks w ith much further improved accuracy attracts attentions w orld-w idely. The time-transfer technique based on optical pulses has the highest precision presently,and the further improvement in the accuracy is heavily dependent on the time-domain properties of the pulse as w ell as the sensitivity of the applied measurement on the exchanged pulse. The application of optical frequency comb in time transfer for a precision up to femtosecond level are currently the focus of much interest,and has recently achieved many breakthroughs. Further investigations show that,utilizing quantum techniques,i.e. quantum measurement technique and quantum optical pulse source,can lead to a new limit on the measured timing information. Furthermore,it can be immune from atmospheric parameters,such as pressure,temperature,humidity and so on.Such quantum improvements on time-transfer have a bright prospect in the future applications requiring extremely high-accuracy timing and ranging. The potential achievements w ill form a technical basis for the future realization of sub-femtosecond time transfer system.
文摘Correlations between two time series,including the linear Pearson correlation and the nonlinear transfer entropy,have attracted significant attention.In this work,we studied the correlations between multiple stock data with the introduction of a time delay and a rolling window.In most cases,the Pearson correlation and transfer entropy share the same tendency,where a higher correlation provides more information for predicting future trends from one stock to another,but a lower correlation provides less.Considering the computational complexity of the transfer entropy and the simplicity of the Pearson correlation,using the linear correlation with time delays and a rolling window is a robust and simple method to quantify the mutual information between stocks.Predictions made by the long short-term memory method with mutual information outperform those made only with selfinformation when there are high correlations between two stocks.
文摘A self-adaptive precise algorithm in the time domain was employed to solve 2-D nonlinear coupled heat and moisture transfer problems. By expanding variables at a discretized time interval, the variations of variables can be described more precisely,and a nonlinear coupled initial and boundary value problem was converted into a series of recurrent linear boundary value problems which are solved by FE technique. In the computation, no additional assumption and the nonlinear iteration are required, and a criterion for self-adaptive computation is proposed to maintain sufficient computing accuracy for the change sizes of time steps. In the numerical comparison, the variations of material properties with temperature, moisture content, and both temperature and moisture content are taken into account, respectively. Satisfactory results have been obtained, indicating that the proposed approach is capable of dealing with complex nonlinear problems.
基金National Natural Science Foundation of China(No.81460236)Major Science and Technology Program of Hainan Province(No.ZDKJ2017007)Innovative Project for Postgraduate of Hainan Province(No.Hys2018-281)。
文摘Objective:To explore the effect of different fertilization time after human chorionic gonadotropin(HCG)injection on the outcome of fertilization in vitro fertilization-embryo transfer(IVF-ET).Methods:One thousand one hundred and forty IVF-ET cycles from January 2016 to August 2018 were analyzed retrospectively.According to the different fertilization time after injection of HCG divided into four groups:Group A(38.0 h~39.0 h),Group B(39.1 h~40.0 h),Group C(40.1 h~41.0 h),and Group D(41.1 h~42.0 h).The normal fertilization rate,the normal cleavage rate,the embryo utilization rate,the high-quality embryo rate,the clinical pregnancy rate,the implantation rate,and the spontaneous abortion rate were analyzed among the groups.Then we investigated the effect of different promotion methods on the outcome of fertilization during the optimal fertilization time.Results:There was no significant difference in 2PN cleavage rate,available embryo rate,clinical pregnancy rate,implantation rate and abortion rate among the four groups(P>0.05).The high-quality embryo rate in Group D(44.6%)was the highest,and was significantly different among the four groups(P<0.05).The normal fertilization rate in Group D(71.6%)was the highest,and was significantly different among the four groups(P<0.05).The normal fertilization rate(78.1%)of antagonist group was significantly higher than other groups(P<0.05).Conclusion:The different fertilization time after HCG injection have effects on high-quality embryo rate and normal fertilization rate of patients in IVF-ET.The appropriate fertilization time of patients in IVF-ET was 41 h~42 h after HCG injection in our reproductive center,improved the clinical pregnancy rate and reduced the early abortion rate.The GnRH-ant protocol is superior to other protocol in IVF-ET.
