To obtain high-performance tissue-adhesive hydrogel embodying excellent mechanical integrity,a supramo-lecular hydrogel patch is fabricated through in situ copolymerization of a liquid-liquid phase separation pre-curs...To obtain high-performance tissue-adhesive hydrogel embodying excellent mechanical integrity,a supramo-lecular hydrogel patch is fabricated through in situ copolymerization of a liquid-liquid phase separation pre-cursor composed of self-complementary 2-2-ureido-4-pyrimidone-based monomer and acrylic acid coupled with subsequent corporation of bioactive epigallocatechin gallate.Remarkably,the prepared supramolecular hydrogel leverages hierarchical multi-strength hydrogen-bonds hinged strategy assisted by alkyl-based hydrophobic pockets,broadening the distribution of binding strength of physical junctions,striking a canonical balance be-tween superb mechanical performance and robust adhesive capacity.Ultimately,the fabricated supramolecular hydrogel patch stands out as a high stretchability(1500%),an excellent tensile strength(2.6 MPa),a superhigh toughness(12.6 MJ m^(-3)),an instant and robust tissue adhesion strength(263.2 kPa for porcine skin),the considerable endurance under cyclic loading and reversible adhesion,a superior burst pressure tolerance(108 kPa)to those of commercially-available tissue sealants,and outstanding anti-swelling behavior.The resultant supramolecular hydrogel patch demonstrates the rapid hemorrhage control within 60 s in liver injury and efficient wound closure and healing effects with alleviated inflammation and reduced scarring in full-thickness skin incision,confirming its medical translation as a promising self-rescue tissue-adhesive patch for hemorrhage prevention and sutureless wound closure.展开更多
连续化制造技术是热轧带钢制造技术发展的重要方向,通过将传统制造流程中独立分散的连铸、加热、轧制等工序高效集成,实现了从钢水到钢卷的连续化生产。它是实现钢铁工业低碳、高效、高质量发展的重要技术路径,是新质生产力的代表。针对...连续化制造技术是热轧带钢制造技术发展的重要方向,通过将传统制造流程中独立分散的连铸、加热、轧制等工序高效集成,实现了从钢水到钢卷的连续化生产。它是实现钢铁工业低碳、高效、高质量发展的重要技术路径,是新质生产力的代表。针对MCCR(multi-modo continuous casting and rolling)多模式连续铸轧产线工艺特点,分析了其实现连续化制造面临的关键技术问题,并基于生产实践提出了成套的解决方案。首先,针对高钢通量连铸需求,构建了涵盖超高拉速连铸、高钢水洁净度控制以及流场稳定控制技术的高钢通量连铸技术体系,突破传统工艺的钢通量与品质瓶颈;其次,开发了耐火材料、结晶器和轧辊3大长寿化关键技术,大幅降低设备损耗并提高运行时间,保障了连续化制造的长周期稳定运行;同时,基于隧道式均热炉的多模式解决方案,实现了单坯/半连续/全连续多模式灵活转换,并配套开发了在线、动态、宽域、高精度厚度/宽度调控技术,有效解决连续化制造生产灵活性不足的问题。此外,通过集成高精度凸度控制、高稳定性能控制、高性能材料制备技术,形成了高品质制造技术体系,以满足全系列高强度钢的高精度制造。最后探讨了连续化制造技术的发展方向,即深度融合绿色低碳、高品质生产和智能化赋能,以期助力未来钢铁工业的转型升级。展开更多
基金supported by National Key Research and Develop-ment Program of China(No.2021YFE0105400)the National Nat-ural Science Foundation of China grant(No.32371404).
文摘To obtain high-performance tissue-adhesive hydrogel embodying excellent mechanical integrity,a supramo-lecular hydrogel patch is fabricated through in situ copolymerization of a liquid-liquid phase separation pre-cursor composed of self-complementary 2-2-ureido-4-pyrimidone-based monomer and acrylic acid coupled with subsequent corporation of bioactive epigallocatechin gallate.Remarkably,the prepared supramolecular hydrogel leverages hierarchical multi-strength hydrogen-bonds hinged strategy assisted by alkyl-based hydrophobic pockets,broadening the distribution of binding strength of physical junctions,striking a canonical balance be-tween superb mechanical performance and robust adhesive capacity.Ultimately,the fabricated supramolecular hydrogel patch stands out as a high stretchability(1500%),an excellent tensile strength(2.6 MPa),a superhigh toughness(12.6 MJ m^(-3)),an instant and robust tissue adhesion strength(263.2 kPa for porcine skin),the considerable endurance under cyclic loading and reversible adhesion,a superior burst pressure tolerance(108 kPa)to those of commercially-available tissue sealants,and outstanding anti-swelling behavior.The resultant supramolecular hydrogel patch demonstrates the rapid hemorrhage control within 60 s in liver injury and efficient wound closure and healing effects with alleviated inflammation and reduced scarring in full-thickness skin incision,confirming its medical translation as a promising self-rescue tissue-adhesive patch for hemorrhage prevention and sutureless wound closure.
文摘连续化制造技术是热轧带钢制造技术发展的重要方向,通过将传统制造流程中独立分散的连铸、加热、轧制等工序高效集成,实现了从钢水到钢卷的连续化生产。它是实现钢铁工业低碳、高效、高质量发展的重要技术路径,是新质生产力的代表。针对MCCR(multi-modo continuous casting and rolling)多模式连续铸轧产线工艺特点,分析了其实现连续化制造面临的关键技术问题,并基于生产实践提出了成套的解决方案。首先,针对高钢通量连铸需求,构建了涵盖超高拉速连铸、高钢水洁净度控制以及流场稳定控制技术的高钢通量连铸技术体系,突破传统工艺的钢通量与品质瓶颈;其次,开发了耐火材料、结晶器和轧辊3大长寿化关键技术,大幅降低设备损耗并提高运行时间,保障了连续化制造的长周期稳定运行;同时,基于隧道式均热炉的多模式解决方案,实现了单坯/半连续/全连续多模式灵活转换,并配套开发了在线、动态、宽域、高精度厚度/宽度调控技术,有效解决连续化制造生产灵活性不足的问题。此外,通过集成高精度凸度控制、高稳定性能控制、高性能材料制备技术,形成了高品质制造技术体系,以满足全系列高强度钢的高精度制造。最后探讨了连续化制造技术的发展方向,即深度融合绿色低碳、高品质生产和智能化赋能,以期助力未来钢铁工业的转型升级。
