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Reliability Analysis of Excavator Rectifier Feedback System with Multi-State Components Based on Belief Universal Generating Function Method
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作者 米金华 李彦锋 +2 位作者 黄洪钟 李爱峰 王晓明 《Journal of Shanghai Jiaotong university(Science)》 EI 2015年第3期344-348,共5页
In view of the complexity and uncertainty of system, both the state performances and state probabilities of multi-state components can be expressed by interval numbers. The belief function theory is used to characteri... In view of the complexity and uncertainty of system, both the state performances and state probabilities of multi-state components can be expressed by interval numbers. The belief function theory is used to characterize the uncertainty caused by various factors. A modified Markov model is proposed to obtain the state probabilities of components at any given moment and subsequently the mass function is used to represent the precise belief degree of state probabilities. Based on the primary studies of universal generating function(UGF)method, a belief UGF(BUGF) method is utilized to analyze the reliability and the uncertainty of excavator rectifier feedback system. This paper provides an available method to evaluate the reliability of multi-state systems(MSSs) with interval state performances and state probabilities, and also avoid the interval expansion problem. 展开更多
关键词 excavator rectifier feedback system multi-state components Markov model belief universal generating function
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Probabilistic distribution and stochastic P-bifurcation of a nonlinear energy-regenerative suspension system with time-delayed feedback control
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作者 Zhao-Bin Zeng Ya-Hui Sun Yang Liu 《Chinese Physics B》 2026年第1期322-330,共9页
Energy-regenerative suspension combined with piezoelectric and electromagnetic transduction has evolved into a core technological pathway in advancing automotive design paradigms.With the aim of improving energy harve... Energy-regenerative suspension combined with piezoelectric and electromagnetic transduction has evolved into a core technological pathway in advancing automotive design paradigms.With the aim of improving energy harvesting performance,time-delayed feedback control is widely used in an energy-regenerative suspension system under different external disturbances in this paper.Meanwhile,limited research has addressed the stochastic dynamics of time-delayed nonlinear energy-regenerative suspension systems.Different from previous studies,this work studies the stochastic response and P-bifurcation of the nonlinear energy-regenerative suspension system with time-delayed feedback control.Firstly,an approximately equivalent dimension reduction system is established by the variable transformation method,and then the stationary probability density function of amplitude is obtained by the stochastic averaging method.Secondly,the precision of the method used in this work is verified by comparing the numerical solutions with the analytical results.Finally,based on the stationary probability density function,the influence of system parameters on stochastic P-bifurcation and the mean output power is discussed. 展开更多
关键词 energy-regenerative suspension stochastic P-bifurcation stochastic resonance time-delayed feedback control
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Differential Vegetation Feedback on the Global Land Monsoon System during the Mid-Holocene and Last Interglacial
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作者 Zhenqian WANG Qiong ZHANG +1 位作者 Jie CHEN Zixuan HAN 《Advances in Atmospheric Sciences》 2026年第1期103-119,共17页
This study investigates the impact of vegetation-climate feedback on the global land monsoon system during the Last Interglacial(LIG,127000 years BP)and the mid-Holocene(MH,6000 years BP)using the earth system model E... This study investigates the impact of vegetation-climate feedback on the global land monsoon system during the Last Interglacial(LIG,127000 years BP)and the mid-Holocene(MH,6000 years BP)using the earth system model EC-Earth3.Our findings indicate that vegetation changes significantly influence the global monsoon area and precipitation patterns,especially in the North African and Indian monsoon regions.The North African monsoon region experienced the most substantial increase in vegetation during both the LIG and MH,resulting in significant increases in monsoonal precipitation by 9.8%and 6.0%,respectively.The vegetation feedback also intensified the Saharan Heat Low,strengthened monsoonal flows,and enhanced precipitation over the North African monsoon region.In contrast,the Indian monsoon region exhibited divergent responses to vegetation changes.During the LIG,precipitation in the Indian monsoon region decreased by 2.2%,while it increased by 1.6%during the MH.These differences highlight the complex and region-specific impacts of vegetation feedback on monsoon systems.Overall,this study demonstrates that vegetation feedback exerts distinct influences on the global monsoon during the MH and LIG.These findings highlight the importance of considering vegetation-climate feedback in understanding past monsoon variability and in predicting future climate change impacts on monsoon systems. 展开更多
关键词 Last Interglacial MID-HOLOCENE global land monsoon vegetation feedback
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Establishing positive feedback between polysulfide conversion and lithium-ion migration in Li-S battery
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作者 Bin Han Xingfa Liu +5 位作者 Yue Chen Kaicheng Yang Ding Ding Kai Chen Jun Xu Qingchi Xu 《Journal of Energy Chemistry》 2026年第2期207-216,I0006,共11页
The performance of lithium-sulfur batteries(LSBs)is severely limited by a detrimental negative feedback loop:sluggish polysulfide conversion kinetics lead to Li_(2)S accumulation,which further hinders lithiumion trans... The performance of lithium-sulfur batteries(LSBs)is severely limited by a detrimental negative feedback loop:sluggish polysulfide conversion kinetics lead to Li_(2)S accumulation,which further hinders lithiumion transport and exacerbates capacity decay.To address this,we propose a positive feedback strategy that simultaneously enhances lithium polysulfides(LiPSs)conversion and lithium-ion diffusion through a rationally designed separator.By modifying the separator with phosphorus-doped two-dimensional hollow holey carbon nanosheets(Hollow HCNS),we establish an interconnected network where rapid LiPSs confinement and conversion within the hollow cavities promote efficient lithium-ion transport,while the improved ion flux further accelerates reaction kinetics.This mutual reinforcement mechanism ensures stable cycling by suppressing the shuttle effect and promoting uniform Li_(2)S deposition,as verified by in situ spectroscopic and electrochemical analysis.The resulting LSBs exhibit high-rate capability,ultralow capacity decay,and exceptional stability under high sulfur loading.This work presents a general approach to overcoming the persistent negative feedback problem in high-energy battery systems by synergistically optimizing catalytic conversion and ionic transport. 展开更多
关键词 Lithium-sulfur batteries Hollow holey carbon nanosheet Positive feedback
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Coprime factors based robust control-oriented identification of errors-in-variables systems in output feedbacks
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作者 Li-Hui Geng Guo-Feng Ji Yong-Li Zhang 《Control Theory and Technology》 2026年第1期127-142,共16页
This paper proposes a robust control-oriented identification method for errors-in-variables(EIV)systems in output feedbacks using frequency-response(FR)experimental data.An important relation between such a closed-loo... This paper proposes a robust control-oriented identification method for errors-in-variables(EIV)systems in output feedbacks using frequency-response(FR)experimental data.An important relation between such a closed-loop EIV system and its coprime factor(CF)uncertainty description is first derived,based on which the FR measurements suitable for plant CF identification are able to be generated.Different factorizations of a given controller in the closed-loop system can be made best use to adjust right coprime factors(RCFs)of the plant so as to realize an improvement on the signal-to-noise ratio of identification experimental data.Subsequently,a nominal RCF model is estimated by linear matrix inequalities from the applicable FR measurements and its associated worst-case errors are quantified from a priori and a posteriori information on the underlying system.A resulting RCF perturbation model set can then be described by the nominal RCF model and its worst-case error bounds.Such a model set capable of being stabilized by the given controller is ready for its robust stabilizing controller redesign and robust performance analysis.Finally,a numerical simulation is given to show the efficacy of the proposed identification method. 展开更多
关键词 Robust control-oriented identification Errors-in-variables system Output feedback Right coprime factors Frequency response
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Insights into Student Perceptions of Error Feedback and Improvement Preferences in Online Programming Education
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作者 Li Zhang Tianze Wang +1 位作者 Jing Jiang Yufei Zhou 《计算机教育》 2026年第3期176-189,共14页
Online programming platforms are popular in programming education.However,there has been no research investigating students’real opinions and expectations of the error feedback mechanisms,leaving educators without a ... Online programming platforms are popular in programming education.However,there has been no research investigating students’real opinions and expectations of the error feedback mechanisms,leaving educators without a solid data foundation when attempting to improve the error feedback mechanisms.This paper makes a survey of 834 students across various programming courses and investigates student perceptions of error feedback mechanisms on online programming platforms.It explores the effectiveness of existing feedback,student satisfaction,and preferences for potential improvements,focusing on automatic error localization and program repair mechanisms.Results reveal a significant portion of students are dissatisfied with current feedback due to its limited informativeness.Students also express a clear demand for stronger feedback mechanisms,such as error localization and repair hints.Nevertheless,they prefer feedback that subtly guides them toward solutions,rather than providing direct and explicit answers,valuing the opportunity to enhance their debugging skills.The findings suggest a need for balanced,educational-focused feedback mechanisms that aid learning while promoting independent problem-solving. 展开更多
关键词 Error feedback Online programming education Program error localization Automated program repair
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DANet:CSI Feedback for Massive MIMO Systems Based on Dual Attention Mechanism
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作者 Li Jun Wang Yukai +3 位作者 Zhang Zhichen He Bo Zheng Wenjing Lin Fei 《China Communications》 2026年第2期285-297,共13页
In massive multiple-input multiple-output(MIMO)systems utilizing frequency division duplexing,optimizing system performance requires user equipment(UE)to compress downlink channel state information(CSI)and transmit it... In massive multiple-input multiple-output(MIMO)systems utilizing frequency division duplexing,optimizing system performance requires user equipment(UE)to compress downlink channel state information(CSI)and transmit it to the base station(BS).As the number of antennas increases,there is a significant rise in the overhead related to CSI feedback,posing considerable challenges to the precise acquisition of CSI by the BS.Existing approaches to CSI feedback utilizing deep learning techniques face challenges such as significant feedback overhead and limited precision in the reconstruction process.This study presents a novel lightweight CSI feedback framework known as the dual attention neural network(DANet).Within the DANet architecture,a dual attention module(DAM)is designed to enhance the network's performance.This DAM includes both channel attention blocks and spatial attention blocks.The channel attention blocks direct the model's focus toward channel features rich in information content while simultaneously suppressing less significant features.This approach enables the extraction of temporal correlations within the CSI matrix.The spatial attention block aids in extracting the correlation between the delay domain and the angle domain in the CSI matrix.By enhancing neural network performance,the DAM reduces information dispersion while enhancing the representation of global interactions.Simulation results demonstrate that DANet exhibits superior normalized mean square error and cosine similarity with comparable complexity compared to existing advanced CSI feedback methods. 展开更多
关键词 CSI feedback deep learning dual attention module(DAM) massive MIMO
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Reliability Modeling and Evaluation of Complex Multi-State System Based on Bayesian Networks Considering Fuzzy Dynamic of Faults 被引量:5
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作者 Fangjun Zuo Meiwei Jia +2 位作者 Guang Wen Huijie Zhang Pingping Liu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2021年第11期993-1012,共20页
In the traditional reliability evaluation based on the Bayesian method,the failure probability of nodes is usually expressed by the average failure rate within a period of time.Aiming at the shortcomings of traditiona... In the traditional reliability evaluation based on the Bayesian method,the failure probability of nodes is usually expressed by the average failure rate within a period of time.Aiming at the shortcomings of traditional Bayesian network reliability evaluation methods,this paper proposes a Bayesian network reliability evaluation method considering dynamics and fuzziness.The fuzzy theory and the dynamic of component failure probability are introduced to construct the dynamic fuzzy set function.Based on the solving characteristics of the dynamic fuzzy set and Bayesian network,the fuzzy dynamic probability and fuzzy dynamic importance degree of the fault state of leaf nodes are solved.Finally,through the dynamic fuzzy reliability analysis of CNC machine tool hydraulic system balance circuit,the application of this method in system reliability evaluation is verified,which provides support for fault diagnosis of CNC machine tools. 展开更多
关键词 Bayesian network(BN) dynamics FUZZY multi-state
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Importance measure of system reliability upgrade for multi-state consecutive k-out-of-n systems 被引量:3
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作者 HonQvan Dui Shubin si +2 位作者 Zhiqiang Cai Shudong Sun Yingfeng Zhang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第6期936-942,共7页
Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system.Traditional importance measures mainly concerned the changing value of the system reli... Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system.Traditional importance measures mainly concerned the changing value of the system reliability caused by the change of the reliability of the component,and seldom considered the joint effect of the probability distribution,improvement rate of the object component.This paper studies the rate of the system reliability upgrading with an improvement of the component reliability for the multi-state consecutive k-out-of-n system.To verify the multi-state consecutive k-out-of-n system reliability upgrading by improving one component based on its improvement rate,an increasing potential importance(IPI)and its physical meaning are described at first.Secondly,the relationship between the IPI and Birnbaum importance measures are discussed.And the IPI for some different improvement actions of the component is further discussed.Thirdly,the characteristics of the IPI are analyzed.Finally,an application to an oil pipeline system is given. 展开更多
关键词 system reliability multi-state consecutive k-out-of-nsystem IMPROVEMENT Birnbaum importance.
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Capacitated stochastic coloured Petri net-based approach for computing two-terminal reliability of multi-state network 被引量:3
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作者 Tao Zhang Bo Guo 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第2期304-313,共10页
Classical network reliability problems assume both net- works and components have only binary states, fully working or fully failed states. But many actual networks are multi-state, such as communication networks and ... Classical network reliability problems assume both net- works and components have only binary states, fully working or fully failed states. But many actual networks are multi-state, such as communication networks and transportation networks. The nodes and arcs in the networks may be in intermediate states which are not fully working either fully failed. A simulation ap- proach for computing the two-terminal reliability of a multi-state network is described. Two-terminal reliability is defined as the probability that d units of demand can be supplied from the source to sink nodes under the time threshold T. The capacities of arcs may be in a stochastic state following any discrete or continuous distribution. The transmission time of each arc is also not a fixed number but stochastic according to its current capacity and de- mand. To solve this problem, a capacitated stochastic coloured Petri net is proposed for modelling the system behaviour. Places and transitions respectively stand for the nodes and arcs of a net- work. Capacitated transition and self-modified token colour with route information are defined to describe the multi-state network. By the simulation, the two-terminal reliability and node importance can be estimated and the optimal route whose reliability is highest can also be given. Finally, two examples of different kinds of multi- state networks are given. 展开更多
关键词 two-terminal reliability multi-state network Petri net (PN) simulation node importance.
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Reliability Analysis of Retracting Actuator with Multi-State Based on Goal Oriented Methodology 被引量:3
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作者 周琳玕 董海平 +2 位作者 伊枭剑 李媛媛 赖岳华 《Journal of Shanghai Jiaotong university(Science)》 EI 2015年第3期307-311,共5页
In order to conduct effective reliability analysis of retracting actuator with multi-state(success state,safety failure state and action failure state), we redefine type-3 operator in goal oriented(GO) method to descr... In order to conduct effective reliability analysis of retracting actuator with multi-state(success state,safety failure state and action failure state), we redefine type-3 operator in goal oriented(GO) method to describe three states of main charge of retracting actuator and improve type-15 operator in GO method to describe the logic relations of multi-state output. The quantitative and qualitative reliability analyses of retracting actuator are made based on GO method in this paper. The system state probability of retracting actuator is obtained through quantitative analysis, and its weakness is found through qualitative analysis. The analysis results show that GO method is effective to improve the reliability of retracting actuator, and this method is also feasible for reliability analysis of other complicated initiating explosive systems. 展开更多
关键词 retracting actuator goal oriented(GO) methodology OPERATOR multi-state reliability analysis
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Integrated importance measure for multi-state coherent systems of k level 被引量:2
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作者 Xibin Zhao Shubin Si +2 位作者 Hongyan Dui Zhiqiang Cai Shudong Sun 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2013年第6期1029-1037,共9页
To verify the effectiveness of the integrated importance measure (IIM) for multi-state coherent systems of k level, the definition and physical meaning of IIM are demonstrated. Then, the improvement potential and Δ... To verify the effectiveness of the integrated importance measure (IIM) for multi-state coherent systems of k level, the definition and physical meaning of IIM are demonstrated. Then, the improvement potential and Δ-importance measures are generalized to multi-state coherent systems based on the system performance level, and the relationships between IIM and traditional importance measures are discussed. The characteristics of IIM are demonstrated in both series and parallel systems. Also, an application to an oil transportation system is given. The comparison results show that: (i) IIM has some useful properties that are not possessed by traditional importance measures; (ii) IIM is effective in evaluating the component role in multi-state systems when the component reliability and the failure rate are simultaneously considered. 展开更多
关键词 multi-state coherent system system performance level integrated importance measure system reliability
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A voltage support control strategy based on three-port flexible multi-state switch in distribution networks 被引量:1
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作者 Bo PENG Guorong ZHANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2020年第8期192-202,共11页
Voltage sags in power system may lead to serious problems such as the off-grid of distributed generation and electrical equipment failures.As a novel type of power electronic equipment,a flexible multi-state switch(FM... Voltage sags in power system may lead to serious problems such as the off-grid of distributed generation and electrical equipment failures.As a novel type of power electronic equipment,a flexible multi-state switch(FMSS)is capable to support the voltage during the grid faults.In this paper,a voltage control strategy to support the voltage in a distribution network is proposed by introducing three-port FMSS.The positive-negative-sequence compensation(PNSC)scheme is adopted to control the active and reactive current.This control scheme eliminates active power oscillations at the port of voltage sags and reduces coupling oscillations of other ports.Based on the characteristics of the voltage support under PNSC scheme,two voltage support strategies are proposed.A proportional-integral controller is introduced to provide the reactive power references,which eliminates the errors when estimating the grid voltage and impedance.A current limiting scheme is adopted to keep the port current in a safe range by adjusting the active and reactive power references.The voltage support strategies in two different voltage sags are simulated,and results show the feasibility and effectiveness of the proposed control strategies. 展开更多
关键词 FLEXIBLE multi-state SWITCH voltage support low-voltage ride-through reactive power control
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Optimal transmission lines assignment with maximal reliabilities in multi-source multi-sink multi-state computer network 被引量:1
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作者 章筠 徐正国 +2 位作者 王文海 卢建刚 孙优贤 《Journal of Central South University》 SCIE EI CAS 2013年第7期1868-1877,共10页
The optimal transmission lines assignment with maximal reliabilities (OTLAMR) in the multi-source multi-sink multi-state computer network (MMMCN) was investigated. The OTLAMR problem contains two sub-problems: the MMM... The optimal transmission lines assignment with maximal reliabilities (OTLAMR) in the multi-source multi-sink multi-state computer network (MMMCN) was investigated. The OTLAMR problem contains two sub-problems: the MMMCN reliabilities evaluation and multi-objective transmission lines assignment optimization. First, a reliability evaluation with a transmission line assignment (RETLA) algorithm is proposed to calculate the MMMCN reliabilities under the cost constraint for a certain transmission lines configuration. Second, the non-dominated sorting genetic algorithm II (NSGA-II) is adopted to find the non-dominated set of the transmission lines assignments based on the reliabilities obtained from the RETLA algorithm. By combining the RETLA and the NSGA-II algorithms together, the RETLA-NSGA II algorithm is proposed to solve the OTLAMR problem. The experiments result show that the RETLA-NSGA II algorithm can provide efficient solutions in a reasonable time, from which the decision makers can choose the best solution based on their preferences and experiences. 展开更多
关键词 multi-state network reliability evaluation transmission lines assignments multi-objective optimization non-dominatedsorting genetic algorithm II
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Importance Analysis of a Multi-state System Based on Direct Partial Logic Derivatives and Multi-valued Decision Diagrams 被引量:1
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作者 古莹奎 李晶 《Journal of Donghua University(English Edition)》 EI CAS 2014年第6期789-792,共4页
Importance analysis quantifies the critical degree of individual component. Compared with the traditional binary state system,importance analysis of the multi-state system is more aligned with the practice. Because th... Importance analysis quantifies the critical degree of individual component. Compared with the traditional binary state system,importance analysis of the multi-state system is more aligned with the practice. Because the multi-valued decision diagram( MDD) can reflect the relationship between the components and the system state bilaterally, it was introduced into the reliability calculation of the multi-state system( MSS). The building method,simplified criteria,and path search and probability algorithm of MSS structure function MDD were given,and the reliability of the system was calculated. The computing methods of importance based on MDD and direct partial logic derivatives( DPLD) were presented. The diesel engine fuel supply system was taken as an example to illustrate the proposed method. The results show that not only the probability of the system in each state can be easily obtained,but also the influence degree of each component and its state on the system reliability can be obtained,which is conducive to the condition monitoring and structure optimization of the system. 展开更多
关键词 multi-state system(MSS) importance analysis reliability multi-valued decision diagram(MDD) direct partial logic derivative(DPLD) diesel engine fuel supply system
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A multi-state weather generator for daily precipitation for the Torne River basin, northern Sweden/western Finland
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作者 David RAYNER Christine ACHBERGER Deliang CHEN 《Advances in Climate Change Research》 SCIE CSCD 2016年第1期70-81,共12页
This paper describes a new weather generator e the 10-state empirical model e that combines a 10-state, first-order Markov chain with a non-parametric precipitation amounts model. Using a doubly-stochastic transition-... This paper describes a new weather generator e the 10-state empirical model e that combines a 10-state, first-order Markov chain with a non-parametric precipitation amounts model. Using a doubly-stochastic transition-matrix results in a weather generator for which the overall precipitation distribution(including both wet and dry days) and the temporal-correlation can be modified independently for climate change studies. This paper assesses the ability of the 10-state empirical model to simulate daily area-average precipitation in the Torne River catchment in northern Sweden/western Finland in the context of 3 other models: a 10-state model with a parametric(Gamma) amounts model; a wet/dry chain with the empirical amounts model; and a wet/dry chain with the parametric amounts model. The ability to accurately simulate the distribution of multi-day precipitation in the catchment is the primary consideration.Results showed that the 10-state empirical model represented accumulated 2- to 14-day precipitation most realistically. Further, the distribution of precipitation on wet days in the catchment is related to the placement of a wet day within a wet-spell, and the 10-state models represented this realistically, while the wet/dry models did not. Although all four models accurately reproduced the annual and monthly averages in the training data, all models underestimated inter-annual and inter-seasonal variance. Even so, the 10-state empirical model performed best.We conclude that the multi-state model is a promising candidate for hydrological applications, as it simulates multi-day precipitation well, but that further development is required to improve the simulation of interannual variation. 展开更多
关键词 Weather generator multi-state Torne River PRECIPITATION
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The Mechanical Stabilization and Multi-States of the Stretched VWF A2 Domain
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作者 Xubin Xie Ying Fang Jianhua Wu 《医用生物力学》 EI CAS CSCD 北大核心 2019年第A01期80-81,共2页
At the vascular injury sites,the ultra-large (UL) multimeric von willebrand Factor (VWF) is released in response to physiological and pathophysiological stimuli,and mediates platelet adhesion,aggregation,and cross-lin... At the vascular injury sites,the ultra-large (UL) multimeric von willebrand Factor (VWF) is released in response to physiological and pathophysiological stimuli,and mediates platelet adhesion,aggregation,and cross-linking to maintain hemostasis.This UL-VWF is specifically cleaved by ADAMTS13(A Disintegrin And Metalloprotease with a ThromboSpondintype-1 motif,member 13)to prevent microvascular thrombosis.Each VWF monomer consists of five types of repeat domains in the order of D1-D2-D’-D3-A1-A2-A3-D4-C1-C2-C3-C4-C5-C6-CK,in which the A2 domain contains the ADAMTS13cleavage site(Tyr1605-Met1606),exposure of which requires mechanical or chemical stimuli.Under flows,fluid shear stress regulates VWF degradation and size distribution through opening the A2 domain and exposing its cleavage site for ADAMTS13.VWF A2 domain contains a C-terminal vicinal disulfide bond,a calcium binding sites,and a flexibleα4-less-loop.These unique structure features together make A2 more sensitive to mechanical signal than other VWF A subdomains,i.e.A1 and A3 domains.It is believed that A2 is first bound with and then cleaved by ADAMTS13,together with force-induced conformation transformation.To reveal molecular basis of this two-step model of VWF hydrolyzation by ADAMTS13,we here examined stretch-induced unfolding processes of VWF A2 domain in more detail by Steered molecular dynamics(SMD)simulations,with the use of crystal structure of VWF A2(PDB ID 3GXB),and observed that there were multiple quasi-stable conformations of stretched A2 until itsβ4-strand and a3-helix were pulled away the central hydrophobic core and the cleavage sites were fully accessible to solvent.Our MD simulation data showed that,in unfolding,at first,the cleavage site residue Tyr1605 was exposed partially and binding sites for Spacer domain of ADAMTS13 were exposed to a high level whenα6-helix was separated from A2 body;then,withβ6-strand and a5-helix been pulled away,the binding sites for Cysrich domain of ADAMTS13 was exposed completely while the exposure degree of Tyr1605 was not improved;further,separation ofβ5-strand andα4-less-loop made Tyr1605 and Met1606 and the respective binding sites for ADAMTS13 Spacer domain,Cys-rich domain,and Disintegrin-like domain be fully exposed to reach the optimal catalytic state;lastly,withβ4-strand separation,the cleavage sites and binding sites all were overstretched,leading to mismatch of ADAMTS13 and A2 conformation especially in the binding sites.This conformational mismatch may cause reduction of ADAMTS13 hydrolysis efficiency.Furthermore,the data of SMD simulations under constant forces demonstrated that,the stretched A2 conformation had different quasi-stable states,which all had the better mechanical stability within simulation time of 100 ns;and the conformational transformation from one state to another must overcome their respective potential barriers.The hydrolysis efficiency should depend on each state of the stretched A2 conformation,because of the exclusive matched-degree of A2 and ADMATS13.This computer prediction on the mechanical stability and multi-states of stretched A2 provides a novel insight into the mechano-chemical regulation on cleavage of A2 by ADAMTS13.It would be helpful for design of related drug targeting the binding sites on A2 and exosites on ADAMTS13 for the treatment of patients with acquired TTP. 展开更多
关键词 VWF PROTEIN UNFOLDING SMD ADMATS13 multi-state of PROTEIN
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Reliability Improvement of Large Multi-state Series-parallel Systems
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作者 Bozena Kwiatuszewska-Sarnecka 《International Journal of Automation and computing》 EI 2006年第2期157-164,共8页
In the paper, excess methods for improving the reliability of multi-state series-parallel systems are presented: for the hot reserve of single components, the cold reserve of single components, and the mixed (hot an... In the paper, excess methods for improving the reliability of multi-state series-parallel systems are presented: for the hot reserve of single components, the cold reserve of single components, and the mixed (hot and cold) reserve of single components. A process is also introduced to improve the reliability of these methods by replacing their components with more reliable ones. New theorems for multi-state limit reliability functions in homogeneous and non-homogeneous series-parallel large systems composed of components with improved reliability are presented, and applied to compare the effects of these systems in different reliability improving methods. 展开更多
关键词 Reliability improvement multi-state system large system limit reliability function.
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Reliability Evaluation and Sensitivity Analysis for Multi-state System Based on Time Degradation Measures
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作者 古莹奎 陈佳 张全新 《Journal of Donghua University(English Edition)》 EI CAS 2016年第2期171-176,共6页
The performance and state of multi-state system depend on its structure and different state combinations of the components. In order to evaluate the reliability of multi-state system effectively,a reliability evaluati... The performance and state of multi-state system depend on its structure and different state combinations of the components. In order to evaluate the reliability of multi-state system effectively,a reliability evaluation and sensitivity analysis method based on the time degradation measures was proposed. The equivalence sets of the multi-state system under different output performances were established. The state combinations were classified according to the performance level. The degradation probability models under different states were established,and the new reliability measures,such as dynamic probability of multi-state system,holding time in each state,dynamic expectation function and integrated expectation function of the performance,were proposed and used to implement the dynamic reliability evaluation and sensitivity analysis. A certain diesel engine fuel feeding system was taken as an application example to illustrate the proposed method. The results show that not only the holding time in the desired state of the components and the system can be predicted,but also the best state component in a certain time period can be obtained. 展开更多
关键词 multi-state system dynamic reliability evaluation performance degradation sensitivity analysis
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Component uncertainty importance measure in complex multi-state system considering epistemic uncertainties
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作者 Rentong CHEN Shaoping WANG +4 位作者 Chao ZHANG Hongyan DUI Yuwei ZHANG Yadong ZHANG Yang LI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第12期31-54,共24页
Importance measures can be used to identify the vulnerable components in an aviation system at the early design stage.However,due to lack of knowledge or less available information on the component or system,the epist... Importance measures can be used to identify the vulnerable components in an aviation system at the early design stage.However,due to lack of knowledge or less available information on the component or system,the epistemic uncertainties may be one of the challenging issues in importance evaluation.In addition,the properties of the aircraft system,which are the fundamentals of the component importance measure,including the hierarchy,dependency,randomness,and uncertainty,should be taken into consideration.To solve these problems,this paper proposes the component Uncertainty Integrated Importance Measure(component UIIM)which considers multiple epistemic uncertainties in the complex multi-state systems.The degradation process for the components is described by a Markov model,and the system reliability model is developed using the Markov hierarchal evidential network.The concept of integrated importance measure is then extended into component UIIM to evaluate the component criticality rather than the component state change criticality,from the perspective of system performance.A case study on displacement compensation hydraulic system is presented to show the effectiveness of the proposed uncertainty importance measure.The results show that the component UIIM can be an effective method for evaluating the component criticality from system performance perspective at the system early design. 展开更多
关键词 Importance measure Epistemic uncertainty multi-state system Evidence theory Markov hierarchal evidential network
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