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Machine learning of pyrite geochemistry reconstructs the multi-stage history of mineral deposits 被引量:1
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作者 Pengpeng Yu Yuan Liu +5 位作者 Hanyu Wang Xi Chen Yi Zheng Wei Cao Yiqu Xiong Hongxiang Shan 《Geoscience Frontiers》 2025年第3期81-93,共13页
The application of machine learning for pyrite discrimination establishes a robust foundation for constructing the ore-forming history of multi-stage deposits;however,published models face challenges related to limite... The application of machine learning for pyrite discrimination establishes a robust foundation for constructing the ore-forming history of multi-stage deposits;however,published models face challenges related to limited,imbalanced datasets and oversampling.In this study,the dataset was expanded to approximately 500 samples for each type,including 508 sedimentary,573 orogenic gold,548 sedimentary exhalative(SEDEX)deposits,and 364 volcanogenic massive sulfides(VMS)pyrites,utilizing random forest(RF)and support vector machine(SVM)methodologies to enhance the reliability of the classifier models.The RF classifier achieved an overall accuracy of 99.8%,and the SVM classifier attained an overall accuracy of 100%.The model was evaluated by a five-fold cross-validation approach with 93.8%accuracy for the RF and 94.9%for the SVM classifier.These results demonstrate the strong feasibility of pyrite classification,supported by a relatively large,balanced dataset and high accuracy rates.The classifier was employed to reveal the genesis of the controversial Keketale Pb-Zn deposit in NW China,which has been inconclusive among SEDEX,VMS,or a SEDEX-VMS transition.Petrographic investigations indicated that the deposit comprises early fine-grained layered pyrite(Py1)and late recrystallized pyrite(Py2).The majority voting classified Py1 as the VMS type,with an accuracy of RF and SVM being 72.2%and 75%,respectively,and confirmed Py2 as an orogenic type with 74.3% and 77.1%accuracy,respectively.The new findings indicated that the Keketale deposit originated from a submarine VMS mineralization system,followed by late orogenic-type overprinting of metamorphism and deformation,which is consistent with the geological and geochemical observations.This study further emphasizes the advantages of Machine learning(ML)methods in accurately and directly discriminating the deposit types and reconstructing the formation history of multi-stage deposits. 展开更多
关键词 Machine learning Random forest Support vector machine PYRITE multi-stage genesis Keketale deposit
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Multi-Stage Voltage Control Optimization Strategy for Distribution Networks Considering Active-Reactive Co-Regulation of Electric Vehicles
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作者 Shukang Lyu Fei Zeng +3 位作者 Huachun Han Huiyu Miao Yi Pan Xiaodong Yuan 《Energy Engineering》 EI 2025年第1期221-242,共22页
The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the exis... The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the existing research has not deeply explored the EV active-reactive synergistic regulating characteristics,and failed to realize themulti-timescale synergistic control with other regulatingmeans,For this reason,this paper proposes amultilevel linkage coordinated optimization strategy to reduce the voltage deviation of the distribution network.Firstly,a capacitor bank reactive power compensation voltage control model and a distributed photovoltaic(PV)activereactive power regulationmodel are established.Additionally,an external characteristicmodel of EVactive-reactive power regulation is developed considering the four-quadrant operational characteristics of the EVcharger.Amultiobjective optimization model of the distribution network is then constructed considering the time-series coupling constraints of multiple types of voltage regulators.A multi-timescale control strategy is proposed by considering the impact of voltage regulators on active-reactive EV energy consumption and PV energy consumption.Then,a four-stage voltage control optimization strategy is proposed for various types of voltage regulators with multiple time scales.Themulti-objective optimization is solved with the improvedDrosophila algorithmto realize the power fluctuation control of the distribution network and themulti-stage voltage control optimization.Simulation results validate that the proposed voltage control optimization strategy achieves the coordinated control of decentralized voltage control resources in the distribution network.It effectively reduces the voltage deviation of the distribution network while ensuring the energy demand of EV users and enhancing the stability and economic efficiency of the distribution network. 展开更多
关键词 Electric vehicle(EV) distribution network multi-stage optimization active-reactive power regulation voltage control
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Multi-stage Mineralization in the Giant Erdaokan Ag-Pb-Zn Deposit,Northeastern China:Evidence from Magnetite EPMA and LA-ICPMS Geochemistry
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作者 FU Anzong LI Chenglu +6 位作者 YANG Wenpeng Masroor ALAM DENG Changzhou YANG Yuanjiang ZHENG Bo ZHAO Ruijun YUAN Maowen 《Acta Geologica Sinica(English Edition)》 2025年第2期532-552,共21页
Although previous researchers have attempted to decipher ore genesis and mineralization in the Erdaokan Ag-Pb-Zn deposit,some uncertainties regarding the mineralization process and evolution of both ore-forming fluids... Although previous researchers have attempted to decipher ore genesis and mineralization in the Erdaokan Ag-Pb-Zn deposit,some uncertainties regarding the mineralization process and evolution of both ore-forming fluids and magnetite types still need to be addressed.In this study,we obtained new EPMA,LA-ICP-MS,and in situ Fe isotope data from magnetite from the Erdaokan deposit,in order to better understand the mineralization mechanism and evolution of both magnetite and the ore-forming fluids.Our results identified seven types of magnetite at Erdaokan:disseminated magnetite(Mag1),coarse-grained magnetite(Mag2a),radial magnetite(Mag2b),fragmented fine-grained magnetite(Mag2c),vermicular gel magnetite(Mag3a1 and Mag3a2),colloidal magnetite(Mag3b)and dark gray magnetite(Mag4).All of the magnetite types were hydrothermal in origin and generally low in Ti(<400 ppm)and Ni(<800 ppm),while being enriched in light Fe isotopes(δ^(56)Fe ranging from−1.54‰to−0.06‰).However,they exhibit different geochemical signatures and are thus classified into high-manganese magnetite(Mag1,MnO>5 wt%),low-silicon magnetite(Mag2a-c,SiO_(2)<1 wt%),high-silicon magnetite(Mag3a-b,SiO_(2)from 1 to 7 wt%)and high-silicon-manganese magnetite(Mag4,SiO_(2)>1 wt%,MnO>0.2 wt%),each being formed within distinct hydrothermal environments.Based on mineralogy,elemental geochemistry,Fe isotopes,temperature trends,TMg-mag and(Ti+V)vs.(Al+Mn)diagrams,we propose that the Erdaokan Ag-Pb-Zn deposit underwent multi-stage mineralization,which can be broken down into four stages and nine sub-stages.Mag1,Mag2a-c,Mag3a-b and Mag4 were formed during the first sub-stage of each of the four stages,respectively.Additionally,fluid mixing,cooling and depressurization boiling were identified as the main mechanisms for mineral precipitation.The enrichment of Ag was significantly enhanced by the superposition of multi-stage ore-forming hydrothermal fluids in the Erdaokan Ag-Pb-Zn deposit. 展开更多
关键词 multi-stage mineralization magnetite geochemistry in situ Fe isotope Erdaokan Ag-Pb-Zn deposit
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Self-supervised multi-stage deep learning network for seismic data denoising
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作者 Omar M.Saad Matteo Ravasi Tariq Alkhalifah 《Artificial Intelligence in Geosciences》 2025年第1期240-249,共10页
Seismic data denoising is a critical process usually applied at various stages of the seismic processing workflow,as our ability to mitigate noise in seismic data affects the quality of our subsequent analyses.However... Seismic data denoising is a critical process usually applied at various stages of the seismic processing workflow,as our ability to mitigate noise in seismic data affects the quality of our subsequent analyses.However,finding an optimal balance between preserving seismic signals and effectively reducing seismic noise presents a substantial challenge.In this study,we introduce a multi-stage deep learning model,trained in a self-supervised manner,designed specifically to suppress seismic noise while minimizing signal leakage.This model operates as a patch-based approach,extracting overlapping patches from the noisy data and converting them into 1D vectors for input.It consists of two identical sub-networks,each configured differently.Inspired by the transformer architecture,each sub-network features an embedded block that comprises two fully connected layers,which are utilized for feature extraction from the input patches.After reshaping,a multi-head attention module enhances the model’s focus on significant features by assigning higher attention weights to them.The key difference between the two sub-networks lies in the number of neurons within their fully connected layers.The first sub-network serves as a strong denoiser with a small number of neurons,effectively attenuating seismic noise;in contrast,the second sub-network functions as a signal-add-back model,using a larger number of neurons to retrieve some of the signal that was not preserved in the output of the first sub-network.The proposed model produces two outputs,each corresponding to one of the sub-networks,and both sub-networks are optimized simultaneously using the noisy data as the label for both outputs.Evaluations conducted on both synthetic and field data demonstrate the model’s effectiveness in suppressing seismic noise with minimal signal leakage,outperforming some benchmark methods. 展开更多
关键词 Seismic data denoising Self-supervised multi-stage deep learning
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New unloading criterion for enhancing multi-stage triaxial tests based on radial strain gradient
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作者 Guodong Jin Shujath Ali Syed +3 位作者 Héctor JoséGonzález-Pérez Hyung Tae Kwak Ali Abdullah Yousef Ali Abdullah Al Dhamen 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第8期4735-4744,共10页
This paper presents a new criterion for determining the unloading points quantitatively and consistently in a multi-stage triaxial test.The radial strain gradient(RSG)is first introduced as an arc tangent function of ... This paper presents a new criterion for determining the unloading points quantitatively and consistently in a multi-stage triaxial test.The radial strain gradient(RSG)is first introduced as an arc tangent function of the rate of change of radial strain to time.RSG is observed to correlate closely with the stress state of a compressed sample,and reaches a horizontal asymptote as approaching failure.For a given rock type,RSG value at peak stress is almost the same,irrespective of the porosity and permeability.These findings lead to the development of RSG criterion:Unloading points can be precisely determined at the time when RSG reaches a pre-determined value that is a little smaller than or equal to the RSG at peak stress.The RSG criterion is validated against other criteria and the single-stage triaxial test on various types of rocks.Failure envelopes from the RSG criterion match well with those from single-stage tests.A practical procedure is recommended to use the RSG criterion:an unconfined compression or single-stage test is first conducted to determine the RSG at peak stress for one sample,the unloading point is then selected to be a value close to the RSG at peak stress,and the multi-stage test is finally performed on another sample using the pre-selected RSG unloading criterion.Generally,the RSG criterion is applicable for any type of rocks,especially brittle rocks,where other criteria are not suitable.Further,it can be practically implemented on the most available rock mechanical testing instruments. 展开更多
关键词 Radial strain gradient Unloading criterion multi-stage triaxial test Mohr-coulomb failure envelope
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Multi-stage and multi-objective optimization of anti-typhoon evacuation strategy for riser with new hang-off system
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作者 Yan-Wei Li Xiu-Quan Liu +3 位作者 Peng-Ji Hu Xiao-Yu Hu Yuan-Jiang Chang Guo-Ming Chen 《Petroleum Science》 2025年第1期457-471,共15页
A new hang-off system has been proposed to improve the security of risers in hang-off modes during typhoons.However,efficient anti-typhoon evacuation strategies have not been investigated.Optimiza-tion model and metho... A new hang-off system has been proposed to improve the security of risers in hang-off modes during typhoons.However,efficient anti-typhoon evacuation strategies have not been investigated.Optimiza-tion model and method for the anti-typhoon evacuation strategies should be researched.Therefore,multi-objective functions are proposed based on operation time,evacuation speed stability,and steering stability.An evacuation path model and a dynamic model of risers with the new hang-off system are developed for design variables and constraints.A multi-objective optimization model with high-dimensional variables and complex constraints is established.Finally,a three-stage optimization method based on genetic algorithm,least square method,and the penalty function method is proposed to solve the multi-objective optimization model.Optimization results show that the operation time can be reduced through operation parameter optimization,especially evacuation heading optimization.The optimal anti-typhoon strategy is evacuation with all risers suspended along a variable path when the direction angle is large,while evacuation with all risers suspended along a straight path at another di-rection angle.Besides,the influencing factors on anti-typhoon evacuation strategies indicate that the proposed optimization model and method have strong applicability to working conditions and remarkable optimization effects. 展开更多
关键词 Anti-typhoon evacuation strategy RISER multi-stage and multi-objective Optimization Genetic algorithm Least square method
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Oxalate modification enabled advanced phosphate removal of nZVI:In Situ formed surface ternary complex and altered multi-stage adsorption process
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作者 Shiyu Cao Jiangshan Li +3 位作者 Yanbiao Shi Furong Guo Tingjuan Gao Lizhi Zhang 《Journal of Environmental Sciences》 2025年第3期79-87,共9页
Nano zero-valent iron(nZVI)is a promising phosphate adsorbent for advanced phosphate removal.However,the rapid passivation of nZVI and the low activity of adsorption sites seriously limit its phosphate removal perform... Nano zero-valent iron(nZVI)is a promising phosphate adsorbent for advanced phosphate removal.However,the rapid passivation of nZVI and the low activity of adsorption sites seriously limit its phosphate removal performance,accounting for its inapplicability to meet the emission criteria of 0.1 mg P/L phosphate.In this study,we report that the oxalate modification can inhibit the passivation of nZVI and alter the multi-stage phosphate adsorption mechanism by changing the adsorption sites.As expected,the stronger antipassivation ability of oxalate modified nZVI(OX-nZVI)strongly favored its phosphate adsorption.Interestingly,the oxalate modification endowed the surface Fe(III)sites with the lowest chemisorption energy and the fastest phosphate adsorption ability than the other adsorption sites,by in situ forming a Fe(III)-phosphate-oxalate ternary complex,therefore enabling an advanced phosphate removal process.At an initial phosphate concentration of 1.00 mg P/L,pH of 6.0 and a dosage of 0.3 g/L of adsorbents,OX-nZVI exhibited faster phosphate removal rate(0.11 g/mg/min)and lower residual phosphate level(0.02 mg P/L)than nZVI(0.055 g/mg/min and 0.19 mg P/L).This study sheds light on the importance of site manipulation in the development of high-performance adsorbents,and offers a facile surface modification strategy to prepare superior iron-basedmaterials for advanced phosphate removal. 展开更多
关键词 Oxalate modification Advanced phosphate removal Nano zero-valent iron(nZVI) Surface ternary complex multi-stage adsorption
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质子FLASH照射对人肝细胞及肝癌细胞辐射损伤比较
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作者 汪越 隋丽 +3 位作者 王巧娟 刘建成 苏鹏 黄志豪 《中华放射医学与防护杂志》 北大核心 2025年第11期1107-1114,共8页
目的研究质子FLASH与常规剂量率(CONV)照射下对人肝细胞WRL68与人肝癌细胞HepG2的差异作用。方法使用100 MeV强流质子回旋加速器对WRL68与HepG2细胞分别开展常规剂量率(0.8 Gy/min)与超高剂量率(40 Gy/s)的质子4 Gy照射,照射后在不同时... 目的研究质子FLASH与常规剂量率(CONV)照射下对人肝细胞WRL68与人肝癌细胞HepG2的差异作用。方法使用100 MeV强流质子回旋加速器对WRL68与HepG2细胞分别开展常规剂量率(0.8 Gy/min)与超高剂量率(40 Gy/s)的质子4 Gy照射,照射后在不同时间点检测细胞增殖、凋亡与周期阻滞变化,并通过转录组测序对不同细胞的基因表达谱变化进行分析。结果对于人肝细胞,相较于常规照射,质子FLASH照射提高了细胞增殖活力(t=10.18~16.67,P<0.05),降低了细胞凋亡率(t=3.21~8.30,P<0.05),同一时间点细胞G2期阻滞占比有所降低(t=34.08~65.16,P<0.05)。对于肝癌细胞,相较于常规照射,质子FLASH照射显著抑制了细胞增殖(t=2.57~9.39,P<0.05),细胞凋亡水平有所提升(t=3.25~66.70,P<0.05),周期变化同样集中于G2期阻滞(t=10.87~27.47,P<0.05)。转录组测序结果显示对于WRL68细胞,在FLASH组与CONV组间共发现906个差异表达基因;对于HepG2细胞,在FLASH组与CONV组间共发现1243个差异表达基因,差异表达基因的基因本体(GO)与京都基因与基因组百科全书(KEGG)分析表明,细胞黏附、氧效应等可能是FLASH-RT的重要微观作用机制。结论质子FLASH照射下人肝细胞放射损伤显著降低,而肝癌细胞损伤加重,相关差异表达基因涉及了多类放射生物学功能通路。 展开更多
关键词 flash照射 质子 肝脏 放射损伤 肝癌
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质子FLASH照射和常规照射对肾癌细胞周期和死亡的影响
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作者 张俊 张思倩 +3 位作者 王巧娟 隋丽 张永胜 曹志飞 《中华放射医学与防护杂志》 北大核心 2025年第11期1100-1106,共7页
目的探究质子FLASH照射(FLASH-IR)和常规照射(CONV-IR)对肾癌细胞周期、细胞凋亡和细胞焦亡的影响。方法分别给予人肾癌细胞株769-P 8 Gy质子照射,FLASH-IR的剂量率为40 Gy/s,CONV-IR的剂量率为0.4 Gy/s,对照(Ctrl)组不照射。照射后24 ... 目的探究质子FLASH照射(FLASH-IR)和常规照射(CONV-IR)对肾癌细胞周期、细胞凋亡和细胞焦亡的影响。方法分别给予人肾癌细胞株769-P 8 Gy质子照射,FLASH-IR的剂量率为40 Gy/s,CONV-IR的剂量率为0.4 Gy/s,对照(Ctrl)组不照射。照射后24 h收集细胞,采用流式细胞术检测细胞周期变化。采用实时荧光定量聚合酶链式反应(RT-qPCR)和蛋白免疫印迹实验,检测肾癌细胞周期、凋亡和焦亡信号通路相关基因与蛋白表达情况。结果质子FLASH-IR使G_(0)/G_(1)期肾癌细胞比例增加[FLASH-IR组vs.Ctrl组:(67.01±0.44)%vs.(38.68±0.63)%,t=-63.99,P<0.05],而CONV-IR使G_(2)/M期肾癌细胞比例增加[CONV-IR组vs.Ctrl组:(56.65±1.52)%vs.(23.67±0.51)%,t=-29.17,P<0.05]。质子FLASH-IR和CONV-IR均导致肾癌细胞发生凋亡(t_(FLASH)=-16.24~-5.01,P<0.05;t_(CONV)=-20.08~6.11,P<0.05)并且CONV-IR激活P53/P21通路(t=-16.86~-9.74,P<0.05)。质子FLASH-IR和CONV-IR同样诱导肾癌细胞发生焦亡(t_(FLASH)=-23.36~20.18,P<0.05;t_(CONV)=-41.62~13.95,P<0.05),且与CONV-IR相比,质子FLASH-IR使肾癌细胞发生焦亡的程度更高(FLASH-IR组vs.CONV-IR:0.96±0.01 vs.0.68±0.44,t=-10.46,P<0.05)。结论质子FLASH照射和常规照射均会影响肾癌细胞周期变化,促进细胞凋亡和焦亡,但两者存在差异,其机制有待进一步探索。质子FLASH照射在肾癌治疗中有潜在应用价值。 展开更多
关键词 flash照射 常规照射 细胞周期 细胞凋亡 细胞焦亡
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X射线FLASH放射治疗的射线来源、计量与防护研究现状
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作者 吴岱 羊奕伟 +3 位作者 张毅 唐瑛鸿 胡旭林 王青青 《中华放射医学与防护杂志》 北大核心 2025年第11期1041-1046,共6页
国际上诸多研究表明,电子线、X射线、质子和重离子都可以用于超高剂量率放疗,其中MV级X射线超高剂量率放疗具有广阔的临床前景。中国工程物理研究院应用电子学研究所基于其在强脉冲射线源领域多年的研究积累,在全球率先解决了兆伏级超... 国际上诸多研究表明,电子线、X射线、质子和重离子都可以用于超高剂量率放疗,其中MV级X射线超高剂量率放疗具有广阔的临床前景。中国工程物理研究院应用电子学研究所基于其在强脉冲射线源领域多年的研究积累,在全球率先解决了兆伏级超高剂量率X射线的产生和计量(剂量测量)难题,助力中国走在相关领域的国际前列。本文主要介绍超高剂量率X射线产生、计量和防护领域的发展历程、现状和未来趋势。这些数据将为研究人员在临床和临床前试验、设备研发和标准制定等多个方面提供可靠的参考,以便实现更精确、更可靠的超高剂量率兆伏级X射线产生和计量,期望对超高剂量率放疗技术的深入研究和临床应用提供支持。 展开更多
关键词 flash放射治疗 X射线 射线源 剂量学
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双源CT Flash扫描联合70 kV在儿童肺炎复查的可行性研究
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作者 张涛 曹永佩 李正正 《中国医学计算机成像杂志》 北大核心 2025年第5期732-737,共6页
目的:探讨双源CT Flash扫描联合70 kV在儿童肺炎复查中的可行性。方法:前瞻性收集2024年1—7月因肺炎就诊我院,并完成前后两次CT扫描的30例患者,其中男14例,女16例,平均年龄(7.3±3.5)岁(5个月~11.5岁),体重指数(BMI)为(15.45±... 目的:探讨双源CT Flash扫描联合70 kV在儿童肺炎复查中的可行性。方法:前瞻性收集2024年1—7月因肺炎就诊我院,并完成前后两次CT扫描的30例患者,其中男14例,女16例,平均年龄(7.3±3.5)岁(5个月~11.5岁),体重指数(BMI)为(15.45±2.62)kg/m^(2)。根据研究方案,均采用Flash模式扫描,首次检查使用80 kV管电压,复查使用70 kV管电压,其余参数相同。比较前后两次CT扫描图像质量、辐射剂量。结果:与首次检查相比,复查的辐射剂量指标CT剂量指数(CTDIvol)、剂量长度乘积(DLP)和全身有效剂量(ED)分别降低了40.38%[(0.31±0.11)mGy vs(0.52±0.20)mGy]、40.74%[(8.67±3.76)mGy·cm vs(14.63±7.18)mGy·cm]和40.91%[(0.13±0.05)mSv vs(0.22±0.10)mSv],差异有统计学意义(均P<0.001);与首次检查图像质量相比,复查图像的背景噪声值增高,信噪比(SNR)值、对比度噪声比(CNR)值分别下降21.14%、13.42%,差异具有统计学意义(均P<0.05);2名医师对两组图像的主观评分一致性高(Kappa=0.72~0.879),两组图像的肺窗和纵隔窗图像质量评分均存在差异(P<0.001),以肺窗图像为判断标准,首次检查图像质量中位评分为5分(4分,5分),复查图像质量的中位评分为4分(3分,5分),所有图像质量均满足诊断需求。结论:70 kV联合双源CT Flash扫描在儿童肺炎复查中具有很好的可行性,图像质量可以满足临床诊断和评价治疗效果需求,且辐射剂量显著降低,值得临床推广使用。 展开更多
关键词 低管电压 双源CT flash模式 低辐射剂量 儿童肺炎
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DSP片上Flash测试系统设计与实现
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作者 王涛 于鹏 钱昀莹 《电子技术应用》 2025年第2期41-45,共5页
在DSP芯片的可靠性筛选考核试验中,片上Flash擦写耐久和数据保持测试是最重要的试验之一。针对内建自测试和外部自动化机台测试的局限性,提出了一种DSP片上Flash测试系统的设计与实现方法。在分析了Flash故障类型和测试算法的基础上,给... 在DSP芯片的可靠性筛选考核试验中,片上Flash擦写耐久和数据保持测试是最重要的试验之一。针对内建自测试和外部自动化机台测试的局限性,提出了一种DSP片上Flash测试系统的设计与实现方法。在分析了Flash故障类型和测试算法的基础上,给出了硬件原理图和软件实现流程,并搭建了实物平台进行效果评估。测试结果表明:该系统可实现多工位DSP片上Flash自动化测试,无需人工参与。同时工作状态可实时显示,测试过程中的数据和结果自动保存在外部存储器中,便于后期进行测试结果统计分析。 展开更多
关键词 片上flash 擦写耐久 数据保持 测试系统
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基于Flash ActionScript语言的凸轮机构运动规律研究
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作者 刘先梅 张明存 《白城师范学院学报》 2025年第2期51-57,共7页
基于Flash ActionScript语言开发了一套参数驱动的平面凸轮机构运动仿真系统,通过设计不同的虚拟实验让使用者了解平面凸轮机构的组成、工作原理、特点及其运动形式.该系统可实现用户注册、密码登陆、凸轮从动件运动规律的实验设计等不... 基于Flash ActionScript语言开发了一套参数驱动的平面凸轮机构运动仿真系统,通过设计不同的虚拟实验让使用者了解平面凸轮机构的组成、工作原理、特点及其运动形式.该系统可实现用户注册、密码登陆、凸轮从动件运动规律的实验设计等不同功能,通过参数化输入时的运动分析与仿真,自动生成凸轮轮廓及不同运动规律下的升程、速度、位移三个线图.研究结果表明,基于Flash ActionScript的凸轮机构运动规律的系统设计,实现了凸轮从动件运动规律的分析. 展开更多
关键词 flash ActionScript语言 平面凸轮机构 运动分析与仿真 参数化
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T-Flash学习软件研发及其在病理学实验课中的U-应用效果研究
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作者 罗康华 刘昕 +2 位作者 吴亚东 刘嘉琪 蒋催蓉 《黔南民族医专学报》 2025年第2期230-233,共4页
目的:本研究旨在解决基础医学病理学实验课学习效果不佳的问题,通过研发手机端T-Flash学习软件,结合智能手机的自主、交互、便携、实时等特性,创新实验课学习方式,以激发学生的学习兴趣,提高学习效果。方法:本研究以Tips(知识小贴士)、T... 目的:本研究旨在解决基础医学病理学实验课学习效果不佳的问题,通过研发手机端T-Flash学习软件,结合智能手机的自主、交互、便携、实时等特性,创新实验课学习方式,以激发学生的学习兴趣,提高学习效果。方法:本研究以Tips(知识小贴士)、Training(训练)和Test(考核)(简称3T)为设计理念,采用消消乐Flash游戏为载体,建立病理标本图片、知识Tips等素材库;在Unity平台制作试用版软件,选取典型病理器官标本和组织切片标本图片制作游戏图标,在游戏载入、返场及点击图标时设计知识Tips闪现滚动;设置闯关关卡、竞技场及积分榜,对在线学习及互动情况进行实时监控和测评;开发基于AI技术的实验小助手,通过病理实验课考试和问卷调查进行软件应用效果评价。结果:设计并开发了T-Flash学习软件v1.0版申请软件著作权获授权。实验组的标本考试成绩与理论考试成绩较对照组显著提高(P<0.05)。T-Flash v1.0版能有效辅助学习,激发学习兴趣,提高学习成绩。50名学生的问卷调查反馈积极,软件受到学生的欢迎。结论:T-Flash消消乐学习软件在基础医学病理学实验课中的创新应用取得了显著成效,证明了其作为新型学习工具的可行性和有效性。该软件不仅能提升学生的学习效果和兴趣,还具有推广到其他学科领域的潜力。本研究为医学教育领域的学习模式创新提供了有益的探索和借鉴。 展开更多
关键词 T-flash学习软件 病理学 实验课 创新教学 flash游戏
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Flash开关单元编程及擦除阈值电压回归模型
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作者 翟培卓 洪根深 +3 位作者 王印权 郑若成 谢儒彬 张庆东 《半导体技术》 北大核心 2025年第2期154-160,共7页
Flash开关单元是实现Flash型现场可编程门阵列(FPGA)的重要配置单元,具有可重构、集成度高、功耗低的优势。采用正交试验设计方法,进行了n型Flash开关单元编程及擦除试验,获取了Sense管和Switch管编程及擦除阈值电压,构建了Sense管编程... Flash开关单元是实现Flash型现场可编程门阵列(FPGA)的重要配置单元,具有可重构、集成度高、功耗低的优势。采用正交试验设计方法,进行了n型Flash开关单元编程及擦除试验,获取了Sense管和Switch管编程及擦除阈值电压,构建了Sense管编程阈值电压、Sense管擦除阈值电压、Switch管编程阈值电压、Switch管擦除阈值电压共四个回归模型。结果表明:所建立模型预测阈值电压的最大误差均不超过0.15 V,平均误差均不超过0.06 V,均具有较高的显著性,模型可信度高;Sense管和Switch管编程阈值电压与编程时间的对数、编程正压、编程负压分别呈线性关系,Sense管和Switch管擦除阈值电压与擦除时间的对数、擦除正压、擦除负压亦分别呈线性关系。回归模型可为Flash开关单元操作波形的设计和优化提供参考依据。 展开更多
关键词 正交试验 flash 开关单元 阈值电压 回归模型
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双源CT Turbo-Flash扫描模式CTA评价冠状动脉狭窄的价值分析
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作者 雷力行 黄小华 +2 位作者 刘念 唐玲玲 马琳竣 《CT理论与应用研究(中英文)》 2025年第6期1128-1135,共8页
目的:分析双源CT Turbo-Flash扫描模式冠状动脉CT血管成像(CCTA)评价冠状动脉狭窄的价值。方法:选取2023年10月至2024年11月我院接受CCTA检查患者150例,依据所采用的扫描模式分为观察组(行双源CT Turbo-Flash扫描模式,n=75)、对照组(采... 目的:分析双源CT Turbo-Flash扫描模式冠状动脉CT血管成像(CCTA)评价冠状动脉狭窄的价值。方法:选取2023年10月至2024年11月我院接受CCTA检查患者150例,依据所采用的扫描模式分为观察组(行双源CT Turbo-Flash扫描模式,n=75)、对照组(采用回顾性心电门控扫描模式,n=75),分析两组扫描参数(CT-血流储备分数(CT-FFR)、管腔内CT强化密度值、Agatston钙化积分、钙化体积)、图像质量(CT值、信噪比(SNR))、辐射剂量(剂量长度乘积(DLP)、容积CT剂量指数(CTDIvol)、有效辐射剂量(ED))。结果:观察组CT-FFR、管腔内CT强化密度值、Agatston钙化积分高于对照组;双源CT Turbo-Flash扫描模式下,随冠状动脉狭窄程度增加,获得的CT-FFR、管腔内CT强化密度值、Agatston钙化积分增加;以数字减影血管造影(DSA)为金标准,观察组诊断冠状动脉中重度狭窄的敏感度、特异度、准确度分别为96.43%、87.23%和90.67%,与对照组差异均无统计学意义;两组CT值、SNR、图像质量比较差异无统计学意义;观察组DLP、CTDIvol、ED均低于对照组。结论:双源CT Turbo-Flash扫描模式下行CCTA检查,评估冠状动脉狭窄的准确性、图像质量较好,可通过定量参数对狭窄程度予以评估,同时其DLP、CTDIvol、ED均较少,值得在临床推广实践。 展开更多
关键词 双源CT Turbo-flash扫描模式 冠状动脉CT成像 冠状动脉狭窄 图像质量 有效辐射剂量
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应用于Flash型FPGA的正高压电荷泵 被引量:1
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作者 江少祥 禹胜林 +1 位作者 马金龙 吴楚彬 《电子科技》 2025年第3期75-81,共7页
Flash型FPGA(Filed Programmable Gate Array)在进行编程操作时,电荷泵为编程管栅端提供正高压。为满足Flash型FPGA的上电及时运行性和编程稳定性,要求电荷泵不仅能输出高压,还应具有较快的启动速度和较小的输出电压纹波。文中基于传统... Flash型FPGA(Filed Programmable Gate Array)在进行编程操作时,电荷泵为编程管栅端提供正高压。为满足Flash型FPGA的上电及时运行性和编程稳定性,要求电荷泵不仅能输出高压,还应具有较快的启动速度和较小的输出电压纹波。文中基于传统交叉耦合电荷泵提出一种正高压电荷泵。电荷泵的主体采取并联双支路结构,降低了输出电压纹波,采用六相不交叠时钟和新增时钟升压模块对电荷泵进行时序控制,在消除了反向电流影响的同时提高了电荷泵启动速度。在输出端设置稳压模块进行稳压调节,保证编程稳定性。仿真结果表明,在电源电压为3.3 V、时钟频率为20 MHz、负载电容为50 pF的条件下,电荷泵启动时间为6.6μs,输出电压稳定到15 V,输出纹波仅有23 mV。采用0.18μm CMOS(Complementary Metal Oxide Semiconductor)工艺流片后,测试结果满足Flash型FPGA的编程需求。 展开更多
关键词 flash型FPGA 编程 高压 交叉耦合 并联双支路 六相不交叠时钟 纹波 电荷泵
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高能X射线FLASH照射临床前研究专家共识
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作者 中国医学装备协会放射治疗设备与技术分会 杜小波 +2 位作者 曲宝林 林斌伟 高峰 《中华放射医学与防护杂志》 北大核心 2025年第11期1052-1060,共9页
FLASH技术是指剂量率≥40 Gy/s的照射,与常规剂量率放疗相比,可显著减轻正常组织损伤,同时具备同样的肿瘤杀伤能力,并且缩短了放疗时间。X-FLASH是一种全新的放疗技术,为了加速其临床转化,相关临床前研究数量快速增长,但缺乏操作规范共... FLASH技术是指剂量率≥40 Gy/s的照射,与常规剂量率放疗相比,可显著减轻正常组织损伤,同时具备同样的肿瘤杀伤能力,并且缩短了放疗时间。X-FLASH是一种全新的放疗技术,为了加速其临床转化,相关临床前研究数量快速增长,但缺乏操作规范共识。本共识旨在建立一套标准化的X-FLASH临床前研究体系,涵盖辐射剂量学、细胞、健康小鼠与荷瘤小鼠模型辐照等全流程规范,为解析FLASH效应机制、验证设备性能及指导临床研究提供可复制的临床前研究操作流程。 展开更多
关键词 高能X射线 flash照射 临床前研究 实验操作流程 专家共识
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重离子FLASH照射减轻急性肠道损伤及其调控机制
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作者 杨雨晨 韩佳颖 +5 位作者 李小波 张俊昱 周利荣 石健 邓小武 朱红玉 《中华放射医学与防护杂志》 北大核心 2025年第11期1092-1099,共8页
目的研究碳离子FLASH照射(FLASH-RT)和常规剂量率照射(CONV-RT)后小鼠的急性肠损伤差异及调控机制。方法将健康C57BL/6J小鼠27只按随机数表法抽取分为对照组(Control组)、FLASH-RT组(100 Gy/s)与CONV-RT组(0.1 Gy/s),每组9只,进行碳离... 目的研究碳离子FLASH照射(FLASH-RT)和常规剂量率照射(CONV-RT)后小鼠的急性肠损伤差异及调控机制。方法将健康C57BL/6J小鼠27只按随机数表法抽取分为对照组(Control组)、FLASH-RT组(100 Gy/s)与CONV-RT组(0.1 Gy/s),每组9只,进行碳离子全腹照射。通过磷酸化组蛋白H2AX(γ-H2AX)、细胞核相关抗原67(Ki67)免疫组织化学检测DNA双链断裂(DSB)及细胞增殖;末端脱氧核苷酸转移酶介导dUTP缺口末端标记法(TUNEL)分析凋亡;结合转录组测序解析FLASH-RT和CONV-RT后分子通路差异。结果与CONV-RT组相比,FLASH-RT组照射后3 h,肠道γ-H2AX信号显著降低(t=3.80,P<0.01);照射后6 h肠道隐窝基底Ki67表达显著增加(t=4.30,P<0.001);照射后12 h TUNEL阳性细胞数减少(t=3.08,P<0.01)。转录组测序分析显示,FLASH-RT特异性激活胰岛素样生长因子(IGF)通路,避免CONV-RT诱导的核因子κB(NF-κB)、B细胞受体炎症通路过度激活及能量代谢抑制。结论相较于CONV-RT,碳离子FLASH-RT可以减少DSB损伤,保留肠道干细胞增殖活性,且激活IGF通路及炎症、调控免疫及代谢通路,从而显著减轻急性肠道上皮损伤。其中,DSB减少介导的修复通路调控与炎症通路抑制是潜在的正常组织保护机制。 展开更多
关键词 碳离子放射治疗 flash 放射性肠道损伤 双链断裂 转录组学
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大规模Flash型FPGA整体功能仿真验证方法研究
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作者 蔺旭辉 马金龙 +3 位作者 曹杨 熊永生 曹靓 赵桂林 《电子与封装》 2025年第1期71-76,共6页
提出了一种大规模Flash型FPGA整体电路编程后功能仿真验证的方法。通过对核心Flash单元建立数字Verilog等效模型,采用整体数字仿真验证和模拟仿真验证的方法,结合编程功能案例,对器件内部所有的资源模块进行功能仿真验证,并且提出了加... 提出了一种大规模Flash型FPGA整体电路编程后功能仿真验证的方法。通过对核心Flash单元建立数字Verilog等效模型,采用整体数字仿真验证和模拟仿真验证的方法,结合编程功能案例,对器件内部所有的资源模块进行功能仿真验证,并且提出了加快整体电路数字仿真速度的方法。将提出的仿真验证方法成功应用于大规模Flash型FPGA芯片设计验证,得到了正确的验证结果,整体电路仿真验证速度得到了显著提升。 展开更多
关键词 flash FPGA VERILOG 验证
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