The spatial offset of bridge has a significant impact on the safety,comfort,and durability of high-speed railway(HSR)operations,so it is crucial to rapidly and effectively detect the spatial offset of operational HSR ...The spatial offset of bridge has a significant impact on the safety,comfort,and durability of high-speed railway(HSR)operations,so it is crucial to rapidly and effectively detect the spatial offset of operational HSR bridges.Drive-by monitoring of bridge uneven settlement demonstrates significant potential due to its practicality,cost-effectiveness,and efficiency.However,existing drive-by methods for detecting bridge offset have limitations such as reliance on a single data source,low detection accuracy,and the inability to identify lateral deformations of bridges.This paper proposes a novel drive-by inspection method for spatial offset of HSR bridge based on multi-source data fusion of comprehensive inspection train.Firstly,dung beetle optimizer-variational mode decomposition was employed to achieve adaptive decomposition of non-stationary dynamic signals,and explore the hidden temporal relationships in the data.Subsequently,a long short-term memory neural network was developed to achieve feature fusion of multi-source signal and accurate prediction of spatial settlement of HSR bridge.A dataset of track irregularities and CRH380A high-speed train responses was generated using a 3D train-track-bridge interaction model,and the accuracy and effectiveness of the proposed hybrid deep learning model were numerically validated.Finally,the reliability of the proposed drive-by inspection method was further validated by analyzing the actual measurement data obtained from comprehensive inspection train.The research findings indicate that the proposed approach enables rapid and accurate detection of spatial offset in HSR bridge,ensuring the long-term operational safety of HSR bridges.展开更多
Domain adaptation aims to reduce the distribution gap between the training data(source domain)and the target data.This enables effective predictions even for domains not seen during training.However,most conventional ...Domain adaptation aims to reduce the distribution gap between the training data(source domain)and the target data.This enables effective predictions even for domains not seen during training.However,most conventional domain adaptation methods assume a single source domain,making them less suitable for modern deep learning settings that rely on diverse and large-scale datasets.To address this limitation,recent research has focused on Multi-Source Domain Adaptation(MSDA),which aims to learn effectively from multiple source domains.In this paper,we propose Efficient Domain Transition for Multi-source(EDTM),a novel and efficient framework designed to tackle two major challenges in existing MSDA approaches:(1)integrating knowledge across different source domains and(2)aligning label distributions between source and target domains.EDTM leverages an ensemble-based classifier expert mechanism to enhance the contribution of source domains that are more similar to the target domain.To further stabilize the learning process and improve performance,we incorporate imitation learning into the training of the target model.In addition,Maximum Classifier Discrepancy(MCD)is employed to align class-wise label distributions between the source and target domains.Experiments were conducted using Digits-Five,one of the most representative benchmark datasets for MSDA.The results show that EDTM consistently outperforms existing methods in terms of average classification accuracy.Notably,EDTM achieved significantly higher performance on target domains such as Modified National Institute of Standards and Technolog with blended background images(MNIST-M)and Street View House Numbers(SVHN)datasets,demonstrating enhanced generalization compared to baseline approaches.Furthermore,an ablation study analyzing the contribution of each loss component validated the effectiveness of the framework,highlighting the importance of each module in achieving optimal performance.展开更多
Benthic habitat mapping is an emerging discipline in the international marine field in recent years,providing an effective tool for marine spatial planning,marine ecological management,and decision-making applications...Benthic habitat mapping is an emerging discipline in the international marine field in recent years,providing an effective tool for marine spatial planning,marine ecological management,and decision-making applications.Seabed sediment classification is one of the main contents of seabed habitat mapping.In response to the impact of remote sensing imaging quality and the limitations of acoustic measurement range,where a single data source does not fully reflect the substrate type,we proposed a high-precision seabed habitat sediment classification method that integrates data from multiple sources.Based on WorldView-2 multi-spectral remote sensing image data and multibeam bathymetry data,constructed a random forests(RF)classifier with optimal feature selection.A seabed sediment classification experiment integrating optical remote sensing and acoustic remote sensing data was carried out in the shallow water area of Wuzhizhou Island,Hainan,South China.Different seabed sediment types,such as sand,seagrass,and coral reefs were effectively identified,with an overall classification accuracy of 92%.Experimental results show that RF matrix optimized by fusing multi-source remote sensing data for feature selection were better than the classification results of simple combinations of data sources,which improved the accuracy of seabed sediment classification.Therefore,the method proposed in this paper can be effectively applied to high-precision seabed sediment classification and habitat mapping around islands and reefs.展开更多
In the heterogeneous power internet of things(IoT)environment,data signals are acquired to support different business systems to realize advanced intelligent applications,with massive,multi-source,heterogeneous and ot...In the heterogeneous power internet of things(IoT)environment,data signals are acquired to support different business systems to realize advanced intelligent applications,with massive,multi-source,heterogeneous and other characteristics.Reliable perception of information and efficient transmission of energy in multi-source heterogeneous environments are crucial issues.Compressive sensing(CS),as an effective method of signal compression and transmission,can accurately recover the original signal only by very few sampling.In this paper,we study a new method of multi-source heterogeneous data signal reconstruction of power IoT based on compressive sensing technology.Based on the traditional compressive sensing technology to directly recover multi-source heterogeneous signals,we fully use the interference subspace information to design the measurement matrix,which directly and effectively eliminates the interference while making the measurement.The measure matrix is optimized by minimizing the average cross-coherence of the matrix,and the reconstruction performance of the new method is further improved.Finally,the effectiveness of the new method with different parameter settings under different multi-source heterogeneous data signal cases is verified by using orthogonal matching pursuit(OMP)and sparsity adaptive matching pursuit(SAMP)for considering the actual environment with prior information utilization of signal sparsity and no prior information utilization of signal sparsity.展开更多
In order to estimate vehicular queue length at signalized intersections accurately and overcome the shortcomings and restrictions of existing studies especially those based on shockwave theory,a new methodology is pre...In order to estimate vehicular queue length at signalized intersections accurately and overcome the shortcomings and restrictions of existing studies especially those based on shockwave theory,a new methodology is presented for estimating vehicular queue length using data from both point detectors and probe vehicles. The methodology applies the shockwave theory to model queue evolution over time and space. Using probe vehicle locations and times as well as point detector measured traffic states,analytical formulations for calculating the maximum and minimum( residual) queue length are developed. The proposed methodology is verified using ground truth data collected from numerical experiments conducted in Shanghai,China. It is found that the methodology has a mean absolute percentage error of 17. 09%,which is reasonably effective in estimating the queue length at traffic signalized intersections. Limitations of the proposed models and algorithms are also discussed in the paper.展开更多
Vibration signals have the characteristics of multi-source strong shock coupling and strong noise interference owing to the complex structure of reciprocating machinery.Therefore,it is difficult to extract,analyze,and...Vibration signals have the characteristics of multi-source strong shock coupling and strong noise interference owing to the complex structure of reciprocating machinery.Therefore,it is difficult to extract,analyze,and diagnose mechanical fault features.To accurately extract sensitive features from the strong noise interference and unsteady monitoring signals of reciprocating machinery,a study on the time-frequency feature extraction method of multi-source shock signals is conducted.Combining the characteristics of reciprocating mechanical vibration signals,a targeted optimization method considering the variational modal decomposition(VMD)mode number and second penalty factor is proposed,which completed the adaptive decomposition of coupled signals.Aiming at the bilateral asymmetric attenuation characteristics of reciprocating mechanical shock signals,a new bilateral adaptive Laplace wavelet(BALW)is established.A search strategy for wavelet local parameters of multi-shock signals is proposed using the harmony search(HS)method.A multi-source shock simulation signal is established,and actual data on the valve fault are obtained through diesel engine fault experiments.The fault recognition rate of the intake and exhaust valve clearance is above 90%and the extraction accuracy of the shock start position is improved by 10°.展开更多
Accurate estimation of understory terrain has significant scientific importance for maintaining ecosystem balance and biodiversity conservation.Addressing the issue of inadequate representation of spatial heterogeneit...Accurate estimation of understory terrain has significant scientific importance for maintaining ecosystem balance and biodiversity conservation.Addressing the issue of inadequate representation of spatial heterogeneity when traditional forest topographic inversion methods consider the entire forest as the inversion unit,this study pro⁃poses a differentiated modeling approach to forest types based on refined land cover classification.Taking Puerto Ri⁃co and Maryland as study areas,a multi-dimensional feature system is constructed by integrating multi-source re⁃mote sensing data:ICESat-2 spaceborne LiDAR is used to obtain benchmark values for understory terrain,topo⁃graphic factors such as slope and aspect are extracted based on SRTM data,and vegetation cover characteristics are analyzed using Landsat-8 multispectral imagery.This study incorporates forest type as a classification modeling con⁃dition and applies the random forest algorithm to build differentiated topographic inversion models.Experimental re⁃sults indicate that,compared to traditional whole-area modeling methods(RMSE=5.06 m),forest type-based classi⁃fication modeling significantly improves the accuracy of understory terrain estimation(RMSE=2.94 m),validating the effectiveness of spatial heterogeneity modeling.Further sensitivity analysis reveals that canopy structure parame⁃ters(with RMSE variation reaching 4.11 m)exert a stronger regulatory effect on estimation accuracy compared to forest cover,providing important theoretical support for optimizing remote sensing models of forest topography.展开更多
To elucidate the fracturing mechanism of deep hard rock under complex disturbance environments,this study investigates the dynamic failure behavior of pre-damaged granite subjected to multi-source dynamic disturbances...To elucidate the fracturing mechanism of deep hard rock under complex disturbance environments,this study investigates the dynamic failure behavior of pre-damaged granite subjected to multi-source dynamic disturbances.Blasting vibration monitoring was conducted in a deep-buried drill-and-blast tunnel to characterize in-situ dynamic loading conditions.Subsequently,true triaxial compression tests incorporating multi-source disturbances were performed using a self-developed wide-low-frequency true triaxial system to simulate disturbance accumulation and damage evolution in granite.The results demonstrate that combined dynamic disturbances and unloading damage significantly accelerate strength degradation and trigger shear-slip failure along preferentially oriented blast-induced fractures,with strength reductions up to 16.7%.Layered failure was observed on the free surface of pre-damaged granite under biaxial loading,indicating a disturbance-induced fracture localization mechanism.Time-stress-fracture-energy coupling fields were constructed to reveal the spatiotemporal characteristics of fracture evolution.Critical precursor frequency bands(105-150,185-225,and 300-325 kHz)were identified,which serve as diagnostic signatures of impending failure.A dynamic instability mechanism driven by multi-source disturbance superposition and pre-damage evolution was established.Furthermore,a grouting-based wave-absorption control strategy was proposed to mitigate deep dynamic disasters by attenuating disturbance amplitude and reducing excitation frequency.展开更多
The SiO_(2) inverse opal photonic crystals(PC)with a three-dimensional macroporous structure were fabricated by the sacrificial template method,followed by infiltration of a pyrene derivative,1-(pyren-8-yl)but-3-en-1-...The SiO_(2) inverse opal photonic crystals(PC)with a three-dimensional macroporous structure were fabricated by the sacrificial template method,followed by infiltration of a pyrene derivative,1-(pyren-8-yl)but-3-en-1-amine(PEA),to achieve a formaldehyde(FA)-sensitive and fluorescence-enhanced sensing film.Utilizing the specific Aza-Cope rearrangement reaction of allylamine of PEA and FA to generate a strong fluorescent product emitted at approximately 480 nm,we chose a PC whose blue band edge of stopband overlapped with the fluorescence emission wavelength.In virtue of the fluorescence enhancement property derived from slow photon effect of PC,FA was detected highly selectively and sensitively.The limit of detection(LoD)was calculated to be 1.38 nmol/L.Furthermore,the fast detection of FA(within 1 min)is realized due to the interconnected three-dimensional macroporous structure of the inverse opal PC and its high specific surface area.The prepared sensing film can be used for the detection of FA in air,aquatic products and living cells.The very close FA content in indoor air to the result from FA detector,the recovery rate of 101.5%for detecting FA in aquatic products and fast fluorescence imaging in 2 min for living cells demonstrate the reliability and accuracy of our method in practical applications.展开更多
Due to the development of cloud computing and machine learning,users can upload their data to the cloud for machine learning model training.However,dishonest clouds may infer user data,resulting in user data leakage.P...Due to the development of cloud computing and machine learning,users can upload their data to the cloud for machine learning model training.However,dishonest clouds may infer user data,resulting in user data leakage.Previous schemes have achieved secure outsourced computing,but they suffer from low computational accuracy,difficult-to-handle heterogeneous distribution of data from multiple sources,and high computational cost,which result in extremely poor user experience and expensive cloud computing costs.To address the above problems,we propose amulti-precision,multi-sourced,andmulti-key outsourcing neural network training scheme.Firstly,we design a multi-precision functional encryption computation based on Euclidean division.Second,we design the outsourcing model training algorithm based on a multi-precision functional encryption with multi-sourced heterogeneity.Finally,we conduct experiments on three datasets.The results indicate that our framework achieves an accuracy improvement of 6%to 30%.Additionally,it offers a memory space optimization of 1.0×2^(24) times compared to the previous best approach.展开更多
Accurate monitoring of track irregularities is very helpful to improving the vehicle operation quality and to formulating appropriate track maintenance strategies.Existing methods have the problem that they rely on co...Accurate monitoring of track irregularities is very helpful to improving the vehicle operation quality and to formulating appropriate track maintenance strategies.Existing methods have the problem that they rely on complex signal processing algorithms and lack multi-source data analysis.Driven by multi-source measurement data,including the axle box,the bogie frame and the carbody accelerations,this paper proposes a track irregularities monitoring network(TIMNet)based on deep learning methods.TIMNet uses the feature extraction capability of convolutional neural networks and the sequence map-ping capability of the long short-term memory model to explore the mapping relationship between vehicle accelerations and track irregularities.The particle swarm optimization algorithm is used to optimize the network parameters,so that both the vertical and lateral track irregularities can be accurately identified in the time and spatial domains.The effectiveness and superiority of the proposed TIMNet is analyzed under different simulation conditions using a vehicle dynamics model.Field tests are conducted to prove the availability of the proposed TIMNet in quantitatively monitoring vertical and lateral track irregularities.Furthermore,comparative tests show that the TIMNet has a better fitting degree and timeliness in monitoring track irregularities(vertical R2 of 0.91,lateral R2 of 0.84 and time cost of 10 ms),compared to other classical regression.The test also proves that the TIMNet has a better anti-interference ability than other regression models.展开更多
This paper deeply discusses the causes of gear howling noise,the identification and analysis of multi-source excitation,the transmission path of dynamic noise,simulation and experimental research,case analysis,optimiz...This paper deeply discusses the causes of gear howling noise,the identification and analysis of multi-source excitation,the transmission path of dynamic noise,simulation and experimental research,case analysis,optimization effect,etc.,aiming to better provide a certain guideline and reference for relevant researchers.展开更多
With the acceleration of intelligent transformation of energy system,the monitoring of equipment operation status and optimization of production process in thermal power plants face the challenge of multi-source heter...With the acceleration of intelligent transformation of energy system,the monitoring of equipment operation status and optimization of production process in thermal power plants face the challenge of multi-source heterogeneous data integration.In view of the heterogeneous characteristics of physical sensor data,including temperature,vibration and pressure that generated by boilers,steam turbines and other key equipment and real-time working condition data of SCADA system,this paper proposes a multi-source heterogeneous data fusion and analysis platform for thermal power plants based on edge computing and deep learning.By constructing a multi-level fusion architecture,the platform adopts dynamic weight allocation strategy and 5D digital twin model to realize the collaborative analysis of physical sensor data,simulation calculation results and expert knowledge.The data fusion module combines Kalman filter,wavelet transform and Bayesian estimation method to solve the problem of data time series alignment and dimension difference.Simulation results show that the data fusion accuracy can be improved to more than 98%,and the calculation delay can be controlled within 500 ms.The data analysis module integrates Dymola simulation model and AERMOD pollutant diffusion model,supports the cascade analysis of boiler combustion efficiency prediction and flue gas emission monitoring,system response time is less than 2 seconds,and data consistency verification accuracy reaches 99.5%.展开更多
Multi-source data fusion provides high-precision spatial situational awareness essential for analyzing granular urban social activities.This study used Shanghai’s catering industry as a case study,leveraging electron...Multi-source data fusion provides high-precision spatial situational awareness essential for analyzing granular urban social activities.This study used Shanghai’s catering industry as a case study,leveraging electronic reviews and consumer data sourced from third-party restaurant platforms collected in 2021.By performing weighted processing on two-dimensional point-of-interest(POI)data,clustering hotspots of high-dimensional restaurant data were identified.A hierarchical network of restaurant hotspots was constructed following the Central Place Theory(CPT)framework,while the Geo-Informatic Tupu method was employed to resolve the challenges posed by network deformation in multi-scale processes.These findings suggest the necessity of enhancing the spatial balance of Shanghai’s urban centers by moderately increasing the number and service capacity of suburban centers at the urban periphery.Such measures would contribute to a more optimized urban structure and facilitate the outward dispersion of comfort-oriented facilities such as the restaurant industry.At a finer spatial scale,the distribution of restaurant hotspots demonstrates a polycentric and symmetric spatial pattern,with a developmental trend radiating outward along the city’s ring roads.This trend can be attributed to the efforts of restaurants to establish connections with other urban functional spaces,leading to the reconfiguration of urban spaces,expansion of restaurant-dedicated land use,and the reorganization of associated commercial activities.The results validate the existence of a polycentric urban structure in Shanghai but also highlight the instability of the restaurant hotspot network during cross-scale transitions.展开更多
Taking the Ming Tombs Forest Farm in Beijing as the research object,this research applied multi-source data fusion and GIS heat-map overlay analysis techniques,systematically collected bird observation point data from...Taking the Ming Tombs Forest Farm in Beijing as the research object,this research applied multi-source data fusion and GIS heat-map overlay analysis techniques,systematically collected bird observation point data from the Global Biodiversity Information Facility(GBIF),population distribution data from the Oak Ridge National Laboratory(ORNL)in the United States,as well as information on the composition of tree species in suitable forest areas for birds and the forest geographical information of the Ming Tombs Forest Farm,which is based on literature research and field investigations.By using GIS technology,spatial processing was carried out on bird observation points and population distribution data to identify suitable bird-watching areas in different seasons.Then,according to the suitability value range,these areas were classified into different grades(from unsuitable to highly suitable).The research findings indicated that there was significant spatial heterogeneity in the bird-watching suitability of the Ming Tombs Forest Farm.The north side of the reservoir was generally a core area with high suitability in all seasons.The deep-aged broad-leaved mixed forests supported the overlapping co-existence of the ecological niches of various bird species,such as the Zosterops simplex and Urocissa erythrorhyncha.In contrast,the shallow forest-edge coniferous pure forests and mixed forests were more suitable for specialized species like Carduelis sinica.The southern urban area and the core area of the mausoleums had relatively low suitability due to ecological fragmentation or human interference.Based on these results,this paper proposed a three-level protection framework of“core area conservation—buffer zone management—isolation zone construction”and a spatio-temporal coordinated human-bird co-existence strategy.It was also suggested that the human-bird co-existence space could be optimized through measures such as constructing sound and light buffer interfaces,restoring ecological corridors,and integrating cultural heritage elements.This research provided an operational technical approach and decision-making support for the scientific planning of bird-watching sites and the coordination of ecological protection and tourism development.展开更多
As coal mining progresses to greater depths,controlling the stability of surrounding rock in deep roadways has become an increasingly complex challenge.Although four-dimensional(4D)support theoretically offers unique ...As coal mining progresses to greater depths,controlling the stability of surrounding rock in deep roadways has become an increasingly complex challenge.Although four-dimensional(4D)support theoretically offers unique advantages in maintaining the stability of rock mass,the disaster evolution processes and multi-source information response characteristics in deep roadways with 4D support remain unclear.Consequently,a large-scale physical model testing system and self-designed 4D support components were employed to conduct similarity model tests on the surrounding rock failure process under unsupported(U-1),traditional bolt-mesh-cable support(T-2),and 4D support(4D-R-3)conditions.Combined with multi-source monitoring techniques,including stress–strain,digital image correlation(DIC),acoustic emission(AE),microseismic(MS),parallel electric(PE),and electromagnetic radiation(EMR),the mechanical behavior and multi-source information responses were comprehensively analyzed.The results show that the peak stress and displacement of the models are positively correlated with the support strength.The multi-source information exhibits distinct response characteristics under different supports.The response frequency,energy,and fluctuationsof AE,MS,and EMR signals,along with the apparent resistivity(AR)high-resistivity zone,follow the trend U-1>T-2>4D-R-3.Furthermore,multi-source information exhibits significantdifferences in sensitivity across different phases.The AE,MS,and EMR signals exhibit active responses to rock mass activity at each phase.However,AR signals are only sensitive to the fracture propagation during the plastic yield and failure phases.In summary,the 4D support significantlyenhances the bearing capacity and plastic deformation of the models,while substantially reducing the frequency,energy,and fluctuationsof multi-source signals.展开更多
In this paper,we propose a novel graph signal processing convolution recurrent network(GSP CRN)for signal enhancement against high suppressive interference(HSI)in wireless communications.GSPCRN consists of the short-t...In this paper,we propose a novel graph signal processing convolution recurrent network(GSP CRN)for signal enhancement against high suppressive interference(HSI)in wireless communications.GSPCRN consists of the short-time graph signal processing(SGSP)approach and a modified convolution recurrent network.Similar to the traditional shorttime time-frequency transformation,SGSP frames the complex-valued communication signal and transforms it to the graph-domain representations,where the connection and weight flexibility of each vertex are fully taken into account.In the presence of HSI,SGSP can extract signal features from new graph-domain dimensions and empower neural networks for weak signal enhancement.Two SGSP methods,adjacency singular value decomposition and implicit graph transformation,are designed to capture relationships among the sampling points in the segmented signals.Simulation results demonstrate that our proposed GSPCRN outperforms existing classic methods in extracting weak signals from the HSI environment.When the interference-to-signal ratio exceeds 27dB,only our proposed GSPCRN can achieve the interference mitigation.展开更多
Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging ...Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging complex networks and interacting with other phytohormones(Liu et al.,2022;Khan et al.,2023).Although phytomelatonin receptors(PMTRs)have been identified in many plants(Wei et al.,2018;Wang et al.,2022;Liu et al.,2025),the downstream signaling mechanisms,particularly receptor-mediated protein modifications and transcriptional regulation,remain poorly characterized.展开更多
Objectives:Postmenopausal osteoporosis is the most common form of osteoporosis in clinical practice,affecting millions of postmenopausal women worldwide.Postmenopausal osteoporosis demands safe and effective therapies...Objectives:Postmenopausal osteoporosis is the most common form of osteoporosis in clinical practice,affecting millions of postmenopausal women worldwide.Postmenopausal osteoporosis demands safe and effective therapies.This study aimed to evaluate the potential of hederagenin(Hed)for treating osteoporosis and to elucidate its underlying mechanisms of action.Methods:The anti-osteoporotic potential of Hed was assessed by investigating its effects on ovariectomy(OVX)-induced bone loss in mice and on receptor activator of NF-kappaB ligand(RANKL)-induced osteoclast differentiation in RAW264.7 cells.Network pharmacology analysis and molecular docking were employed to identify key targets,which were subsequently validated experimentally.Results:In vitro,Hed suppressed osteoclastogenesis by inhibiting the formation of osteoclasts and F-actin rings and by down-regulating osteoclastspecific genes(Atp6v0d2 and Acp5).In vivo,Hed significantly amelioratedOVX-induced bone loss,restoring trabecular bone volume fraction(BV/TV)and trabecular number(Tb.N),while reducing trabecular separation(Tb.Sp).Network pharmacology analysis identified 142 overlapping targets linking Hed to osteoporosis,including tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6),and IL-1β,with enrichment in innate immune signaling and osteoclast differentiation.Molecular docking analysis indicated strong binding affinities between Hed and targets such as TNF-α,IL-6,and IL-1β.Experimentally,Hed was found to decrease RANKL,elevate osteoprotegerin(OPG),and suppress intestinalmRNA levels of pro-inflammatory cytokines such as IL-1β,IL-6,IL-17A,and TNF-α.Conclusion:Hed exerts significant anti-osteoporotic effects inOVX-induced osteoporosis through a dualmechanism involving the suppression of both osteoclastogenesis and innate immune signaling pathways.These findings highlighted Hed’s novel role in modulating immune-bone crosstalk,offering a promising strategy for treating osteolytic diseases without estrogenic side effects.展开更多
The space gravitational wave detection aims to detect gravitational waves in the mHz band in order to study supermassive black hole mergers,galaxy evolution and the structure of the early universe.One of its core payl...The space gravitational wave detection aims to detect gravitational waves in the mHz band in order to study supermassive black hole mergers,galaxy evolution and the structure of the early universe.One of its core payloads is a transponder-type interstellar laser interferometer,designed to measure relative displacement changes at the pico-meter level.Among its components,phasemeter is tasked with extracting the phase and frequency of the interference signal.Currently,phase-locked loop(PLL)phasemeters are commonly employed.However,the second harmonic signal generated by the mixer can restrict both the dynamic range and phase measurement accuracy of the phasemeter.This paper analyzes the interstellar laser interferometer and the impact of the second harmonic signal on the phasemeter's performance.To address these challenges,a phasemeter incorporating a second harmonic signal filter is proposed.This new design mitigates second harmonic disturbances within the phasemeter's bandwidth by dynamically adjusting the filter's cutoff frequency to track the input signal frequency,thereby suppressing the second harmonic signal in real time.Theoretical and simulation analyses demonstrate that the proposed phasemeter with a second harmonic filter significantly enhances the dynamic range.Finally,experimental results verify that the phasemeter can achieve the tracking of sudden frequency changes up to4.8 MHz.展开更多
基金sponsored by the National Natural Science Foundation of China(Grant No.52178100).
文摘The spatial offset of bridge has a significant impact on the safety,comfort,and durability of high-speed railway(HSR)operations,so it is crucial to rapidly and effectively detect the spatial offset of operational HSR bridges.Drive-by monitoring of bridge uneven settlement demonstrates significant potential due to its practicality,cost-effectiveness,and efficiency.However,existing drive-by methods for detecting bridge offset have limitations such as reliance on a single data source,low detection accuracy,and the inability to identify lateral deformations of bridges.This paper proposes a novel drive-by inspection method for spatial offset of HSR bridge based on multi-source data fusion of comprehensive inspection train.Firstly,dung beetle optimizer-variational mode decomposition was employed to achieve adaptive decomposition of non-stationary dynamic signals,and explore the hidden temporal relationships in the data.Subsequently,a long short-term memory neural network was developed to achieve feature fusion of multi-source signal and accurate prediction of spatial settlement of HSR bridge.A dataset of track irregularities and CRH380A high-speed train responses was generated using a 3D train-track-bridge interaction model,and the accuracy and effectiveness of the proposed hybrid deep learning model were numerically validated.Finally,the reliability of the proposed drive-by inspection method was further validated by analyzing the actual measurement data obtained from comprehensive inspection train.The research findings indicate that the proposed approach enables rapid and accurate detection of spatial offset in HSR bridge,ensuring the long-term operational safety of HSR bridges.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2024-00406320)the Institute of Information&Communica-tions Technology Planning&Evaluation(IITP)-Innovative Human Resource Development for Local Intellectualization Program Grant funded by the Korea government(MSIT)(IITP-2026-RS-2023-00259678).
文摘Domain adaptation aims to reduce the distribution gap between the training data(source domain)and the target data.This enables effective predictions even for domains not seen during training.However,most conventional domain adaptation methods assume a single source domain,making them less suitable for modern deep learning settings that rely on diverse and large-scale datasets.To address this limitation,recent research has focused on Multi-Source Domain Adaptation(MSDA),which aims to learn effectively from multiple source domains.In this paper,we propose Efficient Domain Transition for Multi-source(EDTM),a novel and efficient framework designed to tackle two major challenges in existing MSDA approaches:(1)integrating knowledge across different source domains and(2)aligning label distributions between source and target domains.EDTM leverages an ensemble-based classifier expert mechanism to enhance the contribution of source domains that are more similar to the target domain.To further stabilize the learning process and improve performance,we incorporate imitation learning into the training of the target model.In addition,Maximum Classifier Discrepancy(MCD)is employed to align class-wise label distributions between the source and target domains.Experiments were conducted using Digits-Five,one of the most representative benchmark datasets for MSDA.The results show that EDTM consistently outperforms existing methods in terms of average classification accuracy.Notably,EDTM achieved significantly higher performance on target domains such as Modified National Institute of Standards and Technolog with blended background images(MNIST-M)and Street View House Numbers(SVHN)datasets,demonstrating enhanced generalization compared to baseline approaches.Furthermore,an ablation study analyzing the contribution of each loss component validated the effectiveness of the framework,highlighting the importance of each module in achieving optimal performance.
基金Supported by the National Natural Science Foundation of China(Nos.42376185,41876111)the Shandong Provincial Natural Science Foundation(No.ZR2023MD073)。
文摘Benthic habitat mapping is an emerging discipline in the international marine field in recent years,providing an effective tool for marine spatial planning,marine ecological management,and decision-making applications.Seabed sediment classification is one of the main contents of seabed habitat mapping.In response to the impact of remote sensing imaging quality and the limitations of acoustic measurement range,where a single data source does not fully reflect the substrate type,we proposed a high-precision seabed habitat sediment classification method that integrates data from multiple sources.Based on WorldView-2 multi-spectral remote sensing image data and multibeam bathymetry data,constructed a random forests(RF)classifier with optimal feature selection.A seabed sediment classification experiment integrating optical remote sensing and acoustic remote sensing data was carried out in the shallow water area of Wuzhizhou Island,Hainan,South China.Different seabed sediment types,such as sand,seagrass,and coral reefs were effectively identified,with an overall classification accuracy of 92%.Experimental results show that RF matrix optimized by fusing multi-source remote sensing data for feature selection were better than the classification results of simple combinations of data sources,which improved the accuracy of seabed sediment classification.Therefore,the method proposed in this paper can be effectively applied to high-precision seabed sediment classification and habitat mapping around islands and reefs.
基金supported by National Natural Science Foundation of China(12174350)Science and Technology Project of State Grid Henan Electric Power Company(5217Q0240008).
文摘In the heterogeneous power internet of things(IoT)environment,data signals are acquired to support different business systems to realize advanced intelligent applications,with massive,multi-source,heterogeneous and other characteristics.Reliable perception of information and efficient transmission of energy in multi-source heterogeneous environments are crucial issues.Compressive sensing(CS),as an effective method of signal compression and transmission,can accurately recover the original signal only by very few sampling.In this paper,we study a new method of multi-source heterogeneous data signal reconstruction of power IoT based on compressive sensing technology.Based on the traditional compressive sensing technology to directly recover multi-source heterogeneous signals,we fully use the interference subspace information to design the measurement matrix,which directly and effectively eliminates the interference while making the measurement.The measure matrix is optimized by minimizing the average cross-coherence of the matrix,and the reconstruction performance of the new method is further improved.Finally,the effectiveness of the new method with different parameter settings under different multi-source heterogeneous data signal cases is verified by using orthogonal matching pursuit(OMP)and sparsity adaptive matching pursuit(SAMP)for considering the actual environment with prior information utilization of signal sparsity and no prior information utilization of signal sparsity.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51138003)
文摘In order to estimate vehicular queue length at signalized intersections accurately and overcome the shortcomings and restrictions of existing studies especially those based on shockwave theory,a new methodology is presented for estimating vehicular queue length using data from both point detectors and probe vehicles. The methodology applies the shockwave theory to model queue evolution over time and space. Using probe vehicle locations and times as well as point detector measured traffic states,analytical formulations for calculating the maximum and minimum( residual) queue length are developed. The proposed methodology is verified using ground truth data collected from numerical experiments conducted in Shanghai,China. It is found that the methodology has a mean absolute percentage error of 17. 09%,which is reasonably effective in estimating the queue length at traffic signalized intersections. Limitations of the proposed models and algorithms are also discussed in the paper.
基金Supported by National Natural Science Foundation of China (Grant Nos.52101343,52201351)。
文摘Vibration signals have the characteristics of multi-source strong shock coupling and strong noise interference owing to the complex structure of reciprocating machinery.Therefore,it is difficult to extract,analyze,and diagnose mechanical fault features.To accurately extract sensitive features from the strong noise interference and unsteady monitoring signals of reciprocating machinery,a study on the time-frequency feature extraction method of multi-source shock signals is conducted.Combining the characteristics of reciprocating mechanical vibration signals,a targeted optimization method considering the variational modal decomposition(VMD)mode number and second penalty factor is proposed,which completed the adaptive decomposition of coupled signals.Aiming at the bilateral asymmetric attenuation characteristics of reciprocating mechanical shock signals,a new bilateral adaptive Laplace wavelet(BALW)is established.A search strategy for wavelet local parameters of multi-shock signals is proposed using the harmony search(HS)method.A multi-source shock simulation signal is established,and actual data on the valve fault are obtained through diesel engine fault experiments.The fault recognition rate of the intake and exhaust valve clearance is above 90%and the extraction accuracy of the shock start position is improved by 10°.
基金Supported by the National Natural Science Foundation of China(42401488,42071351)the National Key Research and Development Program of China(2020YFA0608501,2017YFB0504204)+4 种基金the Liaoning Revitalization Talents Program(XLYC1802027)the Talent Recruited Program of the Chinese Academy of Science(Y938091)the Project Supported Discipline Innovation Team of the Liaoning Technical University(LNTU20TD-23)the Liaoning Province Doctoral Research Initiation Fund Program(2023-BS-202)the Basic Research Projects of Liaoning Department of Education(JYTQN2023202)。
文摘Accurate estimation of understory terrain has significant scientific importance for maintaining ecosystem balance and biodiversity conservation.Addressing the issue of inadequate representation of spatial heterogeneity when traditional forest topographic inversion methods consider the entire forest as the inversion unit,this study pro⁃poses a differentiated modeling approach to forest types based on refined land cover classification.Taking Puerto Ri⁃co and Maryland as study areas,a multi-dimensional feature system is constructed by integrating multi-source re⁃mote sensing data:ICESat-2 spaceborne LiDAR is used to obtain benchmark values for understory terrain,topo⁃graphic factors such as slope and aspect are extracted based on SRTM data,and vegetation cover characteristics are analyzed using Landsat-8 multispectral imagery.This study incorporates forest type as a classification modeling con⁃dition and applies the random forest algorithm to build differentiated topographic inversion models.Experimental re⁃sults indicate that,compared to traditional whole-area modeling methods(RMSE=5.06 m),forest type-based classi⁃fication modeling significantly improves the accuracy of understory terrain estimation(RMSE=2.94 m),validating the effectiveness of spatial heterogeneity modeling.Further sensitivity analysis reveals that canopy structure parame⁃ters(with RMSE variation reaching 4.11 m)exert a stronger regulatory effect on estimation accuracy compared to forest cover,providing important theoretical support for optimizing remote sensing models of forest topography.
基金supported by the National Key R&D Program of China(No.2023YFB2603602)the National Natural Science Foundation of China(Nos.52222810 and 52178383).
文摘To elucidate the fracturing mechanism of deep hard rock under complex disturbance environments,this study investigates the dynamic failure behavior of pre-damaged granite subjected to multi-source dynamic disturbances.Blasting vibration monitoring was conducted in a deep-buried drill-and-blast tunnel to characterize in-situ dynamic loading conditions.Subsequently,true triaxial compression tests incorporating multi-source disturbances were performed using a self-developed wide-low-frequency true triaxial system to simulate disturbance accumulation and damage evolution in granite.The results demonstrate that combined dynamic disturbances and unloading damage significantly accelerate strength degradation and trigger shear-slip failure along preferentially oriented blast-induced fractures,with strength reductions up to 16.7%.Layered failure was observed on the free surface of pre-damaged granite under biaxial loading,indicating a disturbance-induced fracture localization mechanism.Time-stress-fracture-energy coupling fields were constructed to reveal the spatiotemporal characteristics of fracture evolution.Critical precursor frequency bands(105-150,185-225,and 300-325 kHz)were identified,which serve as diagnostic signatures of impending failure.A dynamic instability mechanism driven by multi-source disturbance superposition and pre-damage evolution was established.Furthermore,a grouting-based wave-absorption control strategy was proposed to mitigate deep dynamic disasters by attenuating disturbance amplitude and reducing excitation frequency.
基金supported by the National Natural Science Foundation of China(21663032 and 22061041)the Open Sharing Platform for Scientific and Technological Resources of Shaanxi Province(2021PT-004)the National Innovation and Entrepreneurship Training Program for College Students of China(S202110719044)。
文摘The SiO_(2) inverse opal photonic crystals(PC)with a three-dimensional macroporous structure were fabricated by the sacrificial template method,followed by infiltration of a pyrene derivative,1-(pyren-8-yl)but-3-en-1-amine(PEA),to achieve a formaldehyde(FA)-sensitive and fluorescence-enhanced sensing film.Utilizing the specific Aza-Cope rearrangement reaction of allylamine of PEA and FA to generate a strong fluorescent product emitted at approximately 480 nm,we chose a PC whose blue band edge of stopband overlapped with the fluorescence emission wavelength.In virtue of the fluorescence enhancement property derived from slow photon effect of PC,FA was detected highly selectively and sensitively.The limit of detection(LoD)was calculated to be 1.38 nmol/L.Furthermore,the fast detection of FA(within 1 min)is realized due to the interconnected three-dimensional macroporous structure of the inverse opal PC and its high specific surface area.The prepared sensing film can be used for the detection of FA in air,aquatic products and living cells.The very close FA content in indoor air to the result from FA detector,the recovery rate of 101.5%for detecting FA in aquatic products and fast fluorescence imaging in 2 min for living cells demonstrate the reliability and accuracy of our method in practical applications.
基金supported by Natural Science Foundation of China(Nos.62303126,62362008,author Z.Z,https://www.nsfc.gov.cn/,accessed on 20 December 2024)Major Scientific and Technological Special Project of Guizhou Province([2024]014)+2 种基金Guizhou Provincial Science and Technology Projects(No.ZK[2022]General149) ,author Z.Z,https://kjt.guizhou.gov.cn/,accessed on 20 December 2024)The Open Project of the Key Laboratory of Computing Power Network and Information Security,Ministry of Education under Grant 2023ZD037,author Z.Z,https://www.gzu.edu.cn/,accessed on 20 December 2024)Open Research Project of the State Key Laboratory of Industrial Control Technology,Zhejiang University,China(No.ICT2024B25),author Z.Z,https://www.gzu.edu.cn/,accessed on 20 December 2024).
文摘Due to the development of cloud computing and machine learning,users can upload their data to the cloud for machine learning model training.However,dishonest clouds may infer user data,resulting in user data leakage.Previous schemes have achieved secure outsourced computing,but they suffer from low computational accuracy,difficult-to-handle heterogeneous distribution of data from multiple sources,and high computational cost,which result in extremely poor user experience and expensive cloud computing costs.To address the above problems,we propose amulti-precision,multi-sourced,andmulti-key outsourcing neural network training scheme.Firstly,we design a multi-precision functional encryption computation based on Euclidean division.Second,we design the outsourcing model training algorithm based on a multi-precision functional encryption with multi-sourced heterogeneity.Finally,we conduct experiments on three datasets.The results indicate that our framework achieves an accuracy improvement of 6%to 30%.Additionally,it offers a memory space optimization of 1.0×2^(24) times compared to the previous best approach.
基金supported by the Sichuan Science and Technology Program(Nos.2024JDRC0100 and 2023YFQ0091)the National Natural Science Foundation of China(Nos.U21A20167 and 52475138)the Scientific Research Foundation of the State Key Laboratory of Rail Transit Vehicle System(No.2024RVL-T08).
文摘Accurate monitoring of track irregularities is very helpful to improving the vehicle operation quality and to formulating appropriate track maintenance strategies.Existing methods have the problem that they rely on complex signal processing algorithms and lack multi-source data analysis.Driven by multi-source measurement data,including the axle box,the bogie frame and the carbody accelerations,this paper proposes a track irregularities monitoring network(TIMNet)based on deep learning methods.TIMNet uses the feature extraction capability of convolutional neural networks and the sequence map-ping capability of the long short-term memory model to explore the mapping relationship between vehicle accelerations and track irregularities.The particle swarm optimization algorithm is used to optimize the network parameters,so that both the vertical and lateral track irregularities can be accurately identified in the time and spatial domains.The effectiveness and superiority of the proposed TIMNet is analyzed under different simulation conditions using a vehicle dynamics model.Field tests are conducted to prove the availability of the proposed TIMNet in quantitatively monitoring vertical and lateral track irregularities.Furthermore,comparative tests show that the TIMNet has a better fitting degree and timeliness in monitoring track irregularities(vertical R2 of 0.91,lateral R2 of 0.84 and time cost of 10 ms),compared to other classical regression.The test also proves that the TIMNet has a better anti-interference ability than other regression models.
文摘This paper deeply discusses the causes of gear howling noise,the identification and analysis of multi-source excitation,the transmission path of dynamic noise,simulation and experimental research,case analysis,optimization effect,etc.,aiming to better provide a certain guideline and reference for relevant researchers.
文摘With the acceleration of intelligent transformation of energy system,the monitoring of equipment operation status and optimization of production process in thermal power plants face the challenge of multi-source heterogeneous data integration.In view of the heterogeneous characteristics of physical sensor data,including temperature,vibration and pressure that generated by boilers,steam turbines and other key equipment and real-time working condition data of SCADA system,this paper proposes a multi-source heterogeneous data fusion and analysis platform for thermal power plants based on edge computing and deep learning.By constructing a multi-level fusion architecture,the platform adopts dynamic weight allocation strategy and 5D digital twin model to realize the collaborative analysis of physical sensor data,simulation calculation results and expert knowledge.The data fusion module combines Kalman filter,wavelet transform and Bayesian estimation method to solve the problem of data time series alignment and dimension difference.Simulation results show that the data fusion accuracy can be improved to more than 98%,and the calculation delay can be controlled within 500 ms.The data analysis module integrates Dymola simulation model and AERMOD pollutant diffusion model,supports the cascade analysis of boiler combustion efficiency prediction and flue gas emission monitoring,system response time is less than 2 seconds,and data consistency verification accuracy reaches 99.5%.
基金Under the auspices of the Key Program of National Natural Science Foundation of China(No.42030409)。
文摘Multi-source data fusion provides high-precision spatial situational awareness essential for analyzing granular urban social activities.This study used Shanghai’s catering industry as a case study,leveraging electronic reviews and consumer data sourced from third-party restaurant platforms collected in 2021.By performing weighted processing on two-dimensional point-of-interest(POI)data,clustering hotspots of high-dimensional restaurant data were identified.A hierarchical network of restaurant hotspots was constructed following the Central Place Theory(CPT)framework,while the Geo-Informatic Tupu method was employed to resolve the challenges posed by network deformation in multi-scale processes.These findings suggest the necessity of enhancing the spatial balance of Shanghai’s urban centers by moderately increasing the number and service capacity of suburban centers at the urban periphery.Such measures would contribute to a more optimized urban structure and facilitate the outward dispersion of comfort-oriented facilities such as the restaurant industry.At a finer spatial scale,the distribution of restaurant hotspots demonstrates a polycentric and symmetric spatial pattern,with a developmental trend radiating outward along the city’s ring roads.This trend can be attributed to the efforts of restaurants to establish connections with other urban functional spaces,leading to the reconfiguration of urban spaces,expansion of restaurant-dedicated land use,and the reorganization of associated commercial activities.The results validate the existence of a polycentric urban structure in Shanghai but also highlight the instability of the restaurant hotspot network during cross-scale transitions.
基金Sponsored by Beijing Youth Innovation Talent Support Program for Urban Greening and Landscaping——The 2024 Special Project for Promoting High-Quality Development of Beijing’s Landscaping through Scientific and Technological Innovation(KJCXQT202410).
文摘Taking the Ming Tombs Forest Farm in Beijing as the research object,this research applied multi-source data fusion and GIS heat-map overlay analysis techniques,systematically collected bird observation point data from the Global Biodiversity Information Facility(GBIF),population distribution data from the Oak Ridge National Laboratory(ORNL)in the United States,as well as information on the composition of tree species in suitable forest areas for birds and the forest geographical information of the Ming Tombs Forest Farm,which is based on literature research and field investigations.By using GIS technology,spatial processing was carried out on bird observation points and population distribution data to identify suitable bird-watching areas in different seasons.Then,according to the suitability value range,these areas were classified into different grades(from unsuitable to highly suitable).The research findings indicated that there was significant spatial heterogeneity in the bird-watching suitability of the Ming Tombs Forest Farm.The north side of the reservoir was generally a core area with high suitability in all seasons.The deep-aged broad-leaved mixed forests supported the overlapping co-existence of the ecological niches of various bird species,such as the Zosterops simplex and Urocissa erythrorhyncha.In contrast,the shallow forest-edge coniferous pure forests and mixed forests were more suitable for specialized species like Carduelis sinica.The southern urban area and the core area of the mausoleums had relatively low suitability due to ecological fragmentation or human interference.Based on these results,this paper proposed a three-level protection framework of“core area conservation—buffer zone management—isolation zone construction”and a spatio-temporal coordinated human-bird co-existence strategy.It was also suggested that the human-bird co-existence space could be optimized through measures such as constructing sound and light buffer interfaces,restoring ecological corridors,and integrating cultural heritage elements.This research provided an operational technical approach and decision-making support for the scientific planning of bird-watching sites and the coordination of ecological protection and tourism development.
基金supported by the National Natural Science Foundation of China(Grant Nos.U22A20598 and 52104107)the"Qinglan Project"of Jiangsu Colleges and Universities,Young Elite Scientists Sponsorship Program of Jiangsu Province(Grant No.TJ-2023-086).
文摘As coal mining progresses to greater depths,controlling the stability of surrounding rock in deep roadways has become an increasingly complex challenge.Although four-dimensional(4D)support theoretically offers unique advantages in maintaining the stability of rock mass,the disaster evolution processes and multi-source information response characteristics in deep roadways with 4D support remain unclear.Consequently,a large-scale physical model testing system and self-designed 4D support components were employed to conduct similarity model tests on the surrounding rock failure process under unsupported(U-1),traditional bolt-mesh-cable support(T-2),and 4D support(4D-R-3)conditions.Combined with multi-source monitoring techniques,including stress–strain,digital image correlation(DIC),acoustic emission(AE),microseismic(MS),parallel electric(PE),and electromagnetic radiation(EMR),the mechanical behavior and multi-source information responses were comprehensively analyzed.The results show that the peak stress and displacement of the models are positively correlated with the support strength.The multi-source information exhibits distinct response characteristics under different supports.The response frequency,energy,and fluctuationsof AE,MS,and EMR signals,along with the apparent resistivity(AR)high-resistivity zone,follow the trend U-1>T-2>4D-R-3.Furthermore,multi-source information exhibits significantdifferences in sensitivity across different phases.The AE,MS,and EMR signals exhibit active responses to rock mass activity at each phase.However,AR signals are only sensitive to the fracture propagation during the plastic yield and failure phases.In summary,the 4D support significantlyenhances the bearing capacity and plastic deformation of the models,while substantially reducing the frequency,energy,and fluctuationsof multi-source signals.
基金supported by he National Social Science Found of China(2022-SKJJ-B-112).
文摘In this paper,we propose a novel graph signal processing convolution recurrent network(GSP CRN)for signal enhancement against high suppressive interference(HSI)in wireless communications.GSPCRN consists of the short-time graph signal processing(SGSP)approach and a modified convolution recurrent network.Similar to the traditional shorttime time-frequency transformation,SGSP frames the complex-valued communication signal and transforms it to the graph-domain representations,where the connection and weight flexibility of each vertex are fully taken into account.In the presence of HSI,SGSP can extract signal features from new graph-domain dimensions and empower neural networks for weak signal enhancement.Two SGSP methods,adjacency singular value decomposition and implicit graph transformation,are designed to capture relationships among the sampling points in the segmented signals.Simulation results demonstrate that our proposed GSPCRN outperforms existing classic methods in extracting weak signals from the HSI environment.When the interference-to-signal ratio exceeds 27dB,only our proposed GSPCRN can achieve the interference mitigation.
基金supported by the grants from the Key Research and Development Program of Xinjiang Uygur autonomous region in China(Grant No.2023B02017)the National Key Research and Development Program of China(Grant No.2024YFD2300703)+1 种基金the financial support from the Beijing Rural Revitalization Agricultural Science and Technology Project(Grant No.NY2401080000),BAIC01-2025the 2115 Talent Development Program of China Agricultural University.
文摘Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging complex networks and interacting with other phytohormones(Liu et al.,2022;Khan et al.,2023).Although phytomelatonin receptors(PMTRs)have been identified in many plants(Wei et al.,2018;Wang et al.,2022;Liu et al.,2025),the downstream signaling mechanisms,particularly receptor-mediated protein modifications and transcriptional regulation,remain poorly characterized.
基金supported by the Scientific Research Project of Anhui ProvincialHealth Commission(Grant No.AHWJ2021b063)National Natural Scientific Foundation of China(Grant No.82160048)+1 种基金Natural Science Foundation Project of Anhui Province(Grant No.2308085MH265)Major Scientific Research Project of Anhui Provincial Department of Education(Grant No.2024AH040205).
文摘Objectives:Postmenopausal osteoporosis is the most common form of osteoporosis in clinical practice,affecting millions of postmenopausal women worldwide.Postmenopausal osteoporosis demands safe and effective therapies.This study aimed to evaluate the potential of hederagenin(Hed)for treating osteoporosis and to elucidate its underlying mechanisms of action.Methods:The anti-osteoporotic potential of Hed was assessed by investigating its effects on ovariectomy(OVX)-induced bone loss in mice and on receptor activator of NF-kappaB ligand(RANKL)-induced osteoclast differentiation in RAW264.7 cells.Network pharmacology analysis and molecular docking were employed to identify key targets,which were subsequently validated experimentally.Results:In vitro,Hed suppressed osteoclastogenesis by inhibiting the formation of osteoclasts and F-actin rings and by down-regulating osteoclastspecific genes(Atp6v0d2 and Acp5).In vivo,Hed significantly amelioratedOVX-induced bone loss,restoring trabecular bone volume fraction(BV/TV)and trabecular number(Tb.N),while reducing trabecular separation(Tb.Sp).Network pharmacology analysis identified 142 overlapping targets linking Hed to osteoporosis,including tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6),and IL-1β,with enrichment in innate immune signaling and osteoclast differentiation.Molecular docking analysis indicated strong binding affinities between Hed and targets such as TNF-α,IL-6,and IL-1β.Experimentally,Hed was found to decrease RANKL,elevate osteoprotegerin(OPG),and suppress intestinalmRNA levels of pro-inflammatory cytokines such as IL-1β,IL-6,IL-17A,and TNF-α.Conclusion:Hed exerts significant anti-osteoporotic effects inOVX-induced osteoporosis through a dualmechanism involving the suppression of both osteoclastogenesis and innate immune signaling pathways.These findings highlighted Hed’s novel role in modulating immune-bone crosstalk,offering a promising strategy for treating osteolytic diseases without estrogenic side effects.
基金the National Key Research&Development Program of China(Grant No.2022YFC2203901)the State Key Laboratory of Spatial Datum(Grant No.SKLSD2025-KF-03)+1 种基金Fundamental Research Funds for the Central UniversitiesSun Yat-sen University for the support。
文摘The space gravitational wave detection aims to detect gravitational waves in the mHz band in order to study supermassive black hole mergers,galaxy evolution and the structure of the early universe.One of its core payloads is a transponder-type interstellar laser interferometer,designed to measure relative displacement changes at the pico-meter level.Among its components,phasemeter is tasked with extracting the phase and frequency of the interference signal.Currently,phase-locked loop(PLL)phasemeters are commonly employed.However,the second harmonic signal generated by the mixer can restrict both the dynamic range and phase measurement accuracy of the phasemeter.This paper analyzes the interstellar laser interferometer and the impact of the second harmonic signal on the phasemeter's performance.To address these challenges,a phasemeter incorporating a second harmonic signal filter is proposed.This new design mitigates second harmonic disturbances within the phasemeter's bandwidth by dynamically adjusting the filter's cutoff frequency to track the input signal frequency,thereby suppressing the second harmonic signal in real time.Theoretical and simulation analyses demonstrate that the proposed phasemeter with a second harmonic filter significantly enhances the dynamic range.Finally,experimental results verify that the phasemeter can achieve the tracking of sudden frequency changes up to4.8 MHz.
