Objective:To compare and analyze the clinical diagnostic value of multi-slice spiral CT and enhanced MRI for primary liver cancer(PLC),and to summarize the imaging findings.Methods:The research subjects in this articl...Objective:To compare and analyze the clinical diagnostic value of multi-slice spiral CT and enhanced MRI for primary liver cancer(PLC),and to summarize the imaging findings.Methods:The research subjects in this article were 50 patients with PLC who were admitted to our hospital from 2017 April to 2018 September.After the patients were admitted,they were examined by multi-slice spiral CT and enhanced MRI scanning,and the pathological diagnosis results were followed up.Relevant information was reviewed and analyzed.Results:The detection rate of multi-slice spiral CT was higher than that of MRI in the portal venous phase lesion detection.The difference was statistically significant(P<0.05).The detection rate of lesions in the arterial phase and delayed phase was not statistically significant(P>0.05);the diagnostic accuracy of multi-slice spiral CT was 85.96%,and the diagnostic accuracy of enhanced MRI scanning was 91.11%,which was not statistically significant(P>0.05).MRI scans showed the capsules of primary liver cancer better than CT,but the difference was not statistically significant(P>0.05).Conclusion:In conclusion,both multi-slice spiral CT and enhanced MRI can be used for the effective diagnosis of primary liver cancer intrahepatic lesions.The diagnostic value of the two is equivalent,but enhanced MRI has a slightly higher diagnostic accuracy and can be used as the preferred method.展开更多
Objective: To analyze and study the diagnostic value of multi-slice spiral CT and magnetic resonance imaging in patients with occult fractures. Methods: Forty patients from our hospital with occult fractures were sele...Objective: To analyze and study the diagnostic value of multi-slice spiral CT and magnetic resonance imaging in patients with occult fractures. Methods: Forty patients from our hospital with occult fractures were selected as the observation group for MRI diagnosis, and 40 patients as the control group for ct diagnosis. The positive detection rates of patients in the two groups were compared. Results The diagnostic effect of MRI technique was superior to that of CT technique (P < 0.05), and the positive detection rate of patients in the control group was lower than that of patients in the observation group. Conclusion The value of MRI three-dimensional reconstruction in patients with occult fractures is higher than that of multi-slice spiral CT technology, the fracture data of patients detected are more accurate, and the effect of its application value is more significant in the case of occult complex fractures, which is worthy of promotion in all hospitals.展开更多
Objective: to study the characteristics and application of spiral CT in early lung cancer. Methods: from January 2020 to November 2021, 40 patients of suspected early lung cancer, all received 64 spiral CT scan and pa...Objective: to study the characteristics and application of spiral CT in early lung cancer. Methods: from January 2020 to November 2021, 40 patients of suspected early lung cancer, all received 64 spiral CT scan and pathological examination, referring to the diagnostic value of 64 layers of spiral CT, and the characteristics of 64 spiral CT imaging and CT of early lung cancer cases with CT perfusion parameters. Results: the pathological examination results of 40 patients suspected early lung cancer were 30 malignant, 10 benign, 64 spiral CT showed malignant, 11 benign, 64 layers of spiral CT was 97.50%, 96.67%, specificity was 100.00%;64 spiral CT confirmed malignant cases, deep segmentation, fine spur, spike, the detection rate of vascular tract collection and vacuolar signs was higher than that in benign cases. Blood flow, permeability, blood volume, and mean passage time CT perfusion parameters were higher than benign cases, and the difference was all statistically significant (P <0.05). Conclusion: the 64-layer spiral CT imaging features, fine burr features and spike features are common in the initial diagnosis of early lung cancer patients, and the blood flow, permeability and blood volume are at high levels, which can provide a practical basis for the differentiation between disease diagnosis and benign and malignant.展开更多
Thirty-four patients with cerebral infarction and 18 patients with transient ischemic attack were examined by multi-slice spiral CT scan, CT perfusion imaging, and CT angiography within 6 hours after onset. By CT perf...Thirty-four patients with cerebral infarction and 18 patients with transient ischemic attack were examined by multi-slice spiral CT scan, CT perfusion imaging, and CT angiography within 6 hours after onset. By CT perfusion imaging, 29 cases in the cerebral infarction group and 10 cases in the transient ischemic attack group presented with abnormal blood flow perfusion, which corresponded to the clinical symptoms. By CT angiography, various degrees of vascular stenosis could be detected in 41 patients, including 33 in the cerebral infarction group and eight in the transient ischemic attack group. The incidence of intracranial artery stenosis was higher than that of extracranial artery stenosis. The intracranial artery stenosis was located predominantly in the middle cerebral artery and carotid artery siphon, while the extracranial artery stenosis occurred mainly in the bifurcation of the common carotid artery and the opening of the vertebral artery. There were 34 cases （83%） with convict vascular stenosis and perfusion abnormalities, and five cases （45%） with perfusion abnormalities but without convict vascular stenosis. The incidence of cerebral infarction in patients with National Institutes of Health Stroke Scale scores 〉 5 points during onset was significantly higher than that in patients with National Institutes of Health Stroke Scale scores 〈 5 points. These experimental findings indicate that the combined application of various CT imaging methods allows early diagnosis of acute ischemic cerebrovascular disease, which can comprehensively analyze the pathogenesis and severity of acute ischemic cerebrovascular disease at the morphological and functional levels.展开更多
Background Multi-slice CT liver perfusion has been widely used in experimental studies of hemodynamic changes in liver lesions, and is usually performed as an adjunct to a conventional CT examination because of its hi...Background Multi-slice CT liver perfusion has been widely used in experimental studies of hemodynamic changes in liver lesions, and is usually performed as an adjunct to a conventional CT examination because of its high temporal and spatial resolution, simple protocol, good reproducibility, and ability to measure hemodynamic changes of liver tissues at the capillary level. Experimental rat models, especially those of induced liver cancer, are often used in studies of hemodynamic changes in liver cancer. Carcinogenesis in rats has a similar pathological progression and characteristics resembling those in human liver cancer; as a result, rat models are often used as ideal animal models in the study of human liver cancer. However, liver perfusion imaging in rats is difficult to perform, because rats＇ livers are so small that different concentrations, flow rates, and dose of contrast agents during the CT perfusion scanning can influence the quality of liver perfusion images in rats. The purpose of this study, therefore, was to investigate the optimal scan protocol for the imaging of hepatic perfusion using a deconvolution mathematical method in rats by comparing the results of rats in different injection conditions of the contrast agent, including concentration, rate and time. Methods Plain CT scan conditions in eighty 2-month-old male Wistar rats were 5.0 mm slice thickness, 5.0 mm interval, 1.0 pitch, 120 kV tube voltage, 60 mA tube current, 512x512 matrix, and FOV 9.6 cm. Perfusion scanning was carried out with different concentrations of diatrizoate （19%, 38%, 57%, and 76%）, different injection rates （0.3 and 0.5 ml/s）, and different injection times （1, 2-3, 4-5, and 6 seconds）. The above conditions were randomly matched and adjusted to determine the best perfusion scan protocol. Three-phase contrast-enhanced scanning was performed after CT perfusion. Histological examination of the liver tissues with hematoxylin and eosin stains was done after CT scanning. Results When the concentration of the contrast agent was 19% or 38%, no pseudo-color map was created. The viscosity increased when the concentration of the contrast agent was 76%; so it is difficult to inject the contrast agent at such a high concentration. Also no pseudo-color map was generated when the injection time was short （1, 2-3, and 4-5 seconds） or the injection rate was low （0.3 ml/s）. The best perfusion images and perfusion parameters were obtained during 50 seconds scanning. Each rat was given an injection of 57% diatrizoate at 0.5 mils via the tail vein using a high-pressure syringe for 6 seconds. The perfusion parameters included hepatic blood flow （HBF）, hepatic blood volume （HBV）, mean transit time （MTT） of the contrast agent, capillary permeability-surface area product （PS）, hepatic arterial index （HAl）, hepatic artery perfusion （HAP）, and hepatic portal perfusion （HPP）. All these parameters reflected the perfusion status of liver parenchyma in normal rats. Three phases of enhancement were modified according to the time-density curves （TDCs） of the perfusion imaging： hepatic arterial phase （7 seconds）, hepatic portal venous phase （15 seconds）, and a delayed phase （23-31 seconds）. On examination by microscopy, the liver tissues were pathologically normal. Conclusions The appropriate protocol with multi-slice spiral CT liver perfusion reflected normal liver hemodynamics in rats. This study laid a solid foundation for further investigation of the physiological characteristics of liver cancer in a rat model, and was an important supplement to and reference for conventional contrast-enhanced CT scans.展开更多
Objective:In the Radiology Department of Mzuzu Central Hospital(MCH),daily training for radiographers now includes content on Computed Tomography(CT)image quality control and equipment maintenance to ensure the normal...Objective:In the Radiology Department of Mzuzu Central Hospital(MCH),daily training for radiographers now includes content on Computed Tomography(CT)image quality control and equipment maintenance to ensure the normal,continuous,and stable operation of the 16-slice spiral CT scanner.Methods:Through comprehensive analysis of relevant equipment,we have identified key parameters that significantly impact CT image quality.Innovative optimization strategies and solutions targeting these parameters have been developed and integrated into daily training programs.Furthermore,starting from an examination of prevalent failure modes observed in CT equipment,we delve into essential maintenance and preservation techniques that CT technologists must master to ensure optimal system performance.Results:(1)Crucial factors affecting CT image quality include artifacts,noise,partial volume effects,and surrounding gap phenomena,alongside spatial and density resolutions,CT dose,reconstruction algorithms,and human factors during the scanning process.In the daily training for radiographers,emphasis is placed on strictly implementing image quality control measures at every stage of the CT scanning process and skillfully applying advanced scanning and image processing techniques.By doing so,we can provide clinicians with accurate and reliable imaging references for diagnosis and treatment.(2)Strategies for CT equipment maintenance:①Environmental inspection of the CT room to ensure cleanliness and hygiene.②Rational and accurate operation,including calibration software proficiency.③Regular maintenance and servicing for minimizing machine downtime.④Maintenance of the CT X-ray tube.CT technicians can become proficient in equipment maintenance and upkeep techniques through training,which can significantly extend the service life of CT systems and reduce the occurrence of malfunctions.Conclusion:Through the regular implementation of rigorous CT image quality control training for radiology technicians,coupled with diligent and proactive CT equipment maintenance,we have observed profound and beneficial impacts on improving image quality.The accuracy and fidelity of radiological data ultimately leads to more accurate diagnoses and effective treatments.展开更多
BACKGROUND： The various combination of multiphase enhancement multislice spiral CT （MSCT） makes the diagno- sis of a small hepatocellular carcinoma （sHCC） on the back- ground of liver cirrhosis possible. This stu...BACKGROUND： The various combination of multiphase enhancement multislice spiral CT （MSCT） makes the diagno- sis of a small hepatocellular carcinoma （sHCC） on the back- ground of liver cirrhosis possible. This study was to explore whether the combination of MSCT enhancement scan and alpha-fetoprotein （AFP） level ficiency for sHCC. could increase the diagnostic ef- METHODS： This study included 35 sHCC patients and 52 cir- rhotic patients without image evidence of HCC as a control group. The diagnoses were made by three radiologists em- ploying a 5-point rating scale, with postoperative pathologic results as the gold standard. Receiver operating characteristic （ROC） curve analysis was performed to evaluate the diag- nostic value of the three MSCT combination modes （arterial phase＋portal-venous phase, arterial phase＋delayed phase, arterial phase＋portal-venous phase＋delayed phase） and AFP levels for sHCC on the background of liver cirrhosis. RESULTS： The area under ROC curve （AUC）, sensitivity, and specificity of the combination of arterial phase＋portal- venous phase＋delayed phase were 0.93, 93%, and 82%, respectively. The average AUC of the arterial phase＋portal- venous phase＋delayed phase combination was significantly greater than that of the arterial phase＋portal-venous phase （AUC=0.84, P=0.01） and arterial phase＋delayed phase （AUC=0.85, P=0.03）. Arterial phase＋portal-venous phase had a smaller AUC （0.84） than arterial phase＋delayed phase （0.85）, but the difference was insignificant （P=0.15）. After combining MSCT enhancement scan with AFP, the AUC, sensitivity, and specificity were 0.95, 94%, and 83%, respectively, indicating a greatly increased diagnostic efficiency for sHCC. CONCLUSIONS： The combination of AFP and 3 phases MSCT enhancement scan could increase the diagnostic efficiency for sHCC on the background of liver cirrhosis. The application of ROC curve analysis has provided a new method and reference in HCC diagnosis.展开更多
目的:分析64排螺旋CT灌注成像(CT perfusion imaging,CTP)参数、血清(Targeting protein for Xenopus kinesin-like protein 2,TPX2)水平与肺癌患者病理特征及预后的相关性。方法:选取2021年6月-2023年11月期间本院收治的77例进行手术...目的:分析64排螺旋CT灌注成像(CT perfusion imaging,CTP)参数、血清(Targeting protein for Xenopus kinesin-like protein 2,TPX2)水平与肺癌患者病理特征及预后的相关性。方法:选取2021年6月-2023年11月期间本院收治的77例进行手术治疗的肺癌患者为研究组,另选取同期本院收治的77例良性病变患者为对照组。分析对比两组、不同病理特征及不同预后患者入院时CTP参数及血清TPX2水平,并分析其相关性。结果:研究组入院时参数血容积(Blood volume,BV)、血流量(Blood flow,BF)、通透性(Permeability surface,PMB)及血清TPX2水平均显著高于对照组(P<0.05)。≥3 cm的肿瘤患者参数BF、PMB及血清TPX2水平均显著高于<3 cm肿瘤患者,鳞癌患者参数BF水平显著高于腺癌患者、腺癌患者显著高于其他类型患者,肺癌患者参数BF、BV及血清TPX2水平随分化程度的加重显著升高,低分化>中分化>高分化,Ⅱ期患者参数BF、BV、PMB及血清TPX2水平均显著高于Ⅰ期患者(P<0.05)。预后不良患者入院时CTP参数BF、BV、PMB及血清TPX2水平均显著高于预后良好患者(P<0.05);参数BF、PEI及血清TPX2均与肿瘤大小呈正相关,参数BF与病理类型呈正相关,参数BF、BV及血清TPX2均于分化程度呈负相关,参数BF、BV、PEI及血清TPX2均于TNM分期及预后呈正相关(P<0.05)。结论:CTP参数及血清TPX2水平与肺癌患者病理特征相关,并在一定程度上反映患者预后情况。展开更多
文摘Objective:To compare and analyze the clinical diagnostic value of multi-slice spiral CT and enhanced MRI for primary liver cancer(PLC),and to summarize the imaging findings.Methods:The research subjects in this article were 50 patients with PLC who were admitted to our hospital from 2017 April to 2018 September.After the patients were admitted,they were examined by multi-slice spiral CT and enhanced MRI scanning,and the pathological diagnosis results were followed up.Relevant information was reviewed and analyzed.Results:The detection rate of multi-slice spiral CT was higher than that of MRI in the portal venous phase lesion detection.The difference was statistically significant(P<0.05).The detection rate of lesions in the arterial phase and delayed phase was not statistically significant(P>0.05);the diagnostic accuracy of multi-slice spiral CT was 85.96%,and the diagnostic accuracy of enhanced MRI scanning was 91.11%,which was not statistically significant(P>0.05).MRI scans showed the capsules of primary liver cancer better than CT,but the difference was not statistically significant(P>0.05).Conclusion:In conclusion,both multi-slice spiral CT and enhanced MRI can be used for the effective diagnosis of primary liver cancer intrahepatic lesions.The diagnostic value of the two is equivalent,but enhanced MRI has a slightly higher diagnostic accuracy and can be used as the preferred method.
文摘Objective: To analyze and study the diagnostic value of multi-slice spiral CT and magnetic resonance imaging in patients with occult fractures. Methods: Forty patients from our hospital with occult fractures were selected as the observation group for MRI diagnosis, and 40 patients as the control group for ct diagnosis. The positive detection rates of patients in the two groups were compared. Results The diagnostic effect of MRI technique was superior to that of CT technique (P < 0.05), and the positive detection rate of patients in the control group was lower than that of patients in the observation group. Conclusion The value of MRI three-dimensional reconstruction in patients with occult fractures is higher than that of multi-slice spiral CT technology, the fracture data of patients detected are more accurate, and the effect of its application value is more significant in the case of occult complex fractures, which is worthy of promotion in all hospitals.
文摘Objective: to study the characteristics and application of spiral CT in early lung cancer. Methods: from January 2020 to November 2021, 40 patients of suspected early lung cancer, all received 64 spiral CT scan and pathological examination, referring to the diagnostic value of 64 layers of spiral CT, and the characteristics of 64 spiral CT imaging and CT of early lung cancer cases with CT perfusion parameters. Results: the pathological examination results of 40 patients suspected early lung cancer were 30 malignant, 10 benign, 64 spiral CT showed malignant, 11 benign, 64 layers of spiral CT was 97.50%, 96.67%, specificity was 100.00%;64 spiral CT confirmed malignant cases, deep segmentation, fine spur, spike, the detection rate of vascular tract collection and vacuolar signs was higher than that in benign cases. Blood flow, permeability, blood volume, and mean passage time CT perfusion parameters were higher than benign cases, and the difference was all statistically significant (P <0.05). Conclusion: the 64-layer spiral CT imaging features, fine burr features and spike features are common in the initial diagnosis of early lung cancer patients, and the blood flow, permeability and blood volume are at high levels, which can provide a practical basis for the differentiation between disease diagnosis and benign and malignant.
基金supported by the Youth Fund of the First Clinical College of Liaoning Medical University, No. 2010C20
文摘Thirty-four patients with cerebral infarction and 18 patients with transient ischemic attack were examined by multi-slice spiral CT scan, CT perfusion imaging, and CT angiography within 6 hours after onset. By CT perfusion imaging, 29 cases in the cerebral infarction group and 10 cases in the transient ischemic attack group presented with abnormal blood flow perfusion, which corresponded to the clinical symptoms. By CT angiography, various degrees of vascular stenosis could be detected in 41 patients, including 33 in the cerebral infarction group and eight in the transient ischemic attack group. The incidence of intracranial artery stenosis was higher than that of extracranial artery stenosis. The intracranial artery stenosis was located predominantly in the middle cerebral artery and carotid artery siphon, while the extracranial artery stenosis occurred mainly in the bifurcation of the common carotid artery and the opening of the vertebral artery. There were 34 cases （83%） with convict vascular stenosis and perfusion abnormalities, and five cases （45%） with perfusion abnormalities but without convict vascular stenosis. The incidence of cerebral infarction in patients with National Institutes of Health Stroke Scale scores 〉 5 points during onset was significantly higher than that in patients with National Institutes of Health Stroke Scale scores 〈 5 points. These experimental findings indicate that the combined application of various CT imaging methods allows early diagnosis of acute ischemic cerebrovascular disease, which can comprehensively analyze the pathogenesis and severity of acute ischemic cerebrovascular disease at the morphological and functional levels.
文摘Background Multi-slice CT liver perfusion has been widely used in experimental studies of hemodynamic changes in liver lesions, and is usually performed as an adjunct to a conventional CT examination because of its high temporal and spatial resolution, simple protocol, good reproducibility, and ability to measure hemodynamic changes of liver tissues at the capillary level. Experimental rat models, especially those of induced liver cancer, are often used in studies of hemodynamic changes in liver cancer. Carcinogenesis in rats has a similar pathological progression and characteristics resembling those in human liver cancer; as a result, rat models are often used as ideal animal models in the study of human liver cancer. However, liver perfusion imaging in rats is difficult to perform, because rats＇ livers are so small that different concentrations, flow rates, and dose of contrast agents during the CT perfusion scanning can influence the quality of liver perfusion images in rats. The purpose of this study, therefore, was to investigate the optimal scan protocol for the imaging of hepatic perfusion using a deconvolution mathematical method in rats by comparing the results of rats in different injection conditions of the contrast agent, including concentration, rate and time. Methods Plain CT scan conditions in eighty 2-month-old male Wistar rats were 5.0 mm slice thickness, 5.0 mm interval, 1.0 pitch, 120 kV tube voltage, 60 mA tube current, 512x512 matrix, and FOV 9.6 cm. Perfusion scanning was carried out with different concentrations of diatrizoate （19%, 38%, 57%, and 76%）, different injection rates （0.3 and 0.5 ml/s）, and different injection times （1, 2-3, 4-5, and 6 seconds）. The above conditions were randomly matched and adjusted to determine the best perfusion scan protocol. Three-phase contrast-enhanced scanning was performed after CT perfusion. Histological examination of the liver tissues with hematoxylin and eosin stains was done after CT scanning. Results When the concentration of the contrast agent was 19% or 38%, no pseudo-color map was created. The viscosity increased when the concentration of the contrast agent was 76%; so it is difficult to inject the contrast agent at such a high concentration. Also no pseudo-color map was generated when the injection time was short （1, 2-3, and 4-5 seconds） or the injection rate was low （0.3 ml/s）. The best perfusion images and perfusion parameters were obtained during 50 seconds scanning. Each rat was given an injection of 57% diatrizoate at 0.5 mils via the tail vein using a high-pressure syringe for 6 seconds. The perfusion parameters included hepatic blood flow （HBF）, hepatic blood volume （HBV）, mean transit time （MTT） of the contrast agent, capillary permeability-surface area product （PS）, hepatic arterial index （HAl）, hepatic artery perfusion （HAP）, and hepatic portal perfusion （HPP）. All these parameters reflected the perfusion status of liver parenchyma in normal rats. Three phases of enhancement were modified according to the time-density curves （TDCs） of the perfusion imaging： hepatic arterial phase （7 seconds）, hepatic portal venous phase （15 seconds）, and a delayed phase （23-31 seconds）. On examination by microscopy, the liver tissues were pathologically normal. Conclusions The appropriate protocol with multi-slice spiral CT liver perfusion reflected normal liver hemodynamics in rats. This study laid a solid foundation for further investigation of the physiological characteristics of liver cancer in a rat model, and was an important supplement to and reference for conventional contrast-enhanced CT scans.
基金supported by the First Affiliated Hospital of Xi’an Jiaotong University Teaching Reform Project(Grant No.JG2023-0206 and JG2022-0324).
文摘Objective:In the Radiology Department of Mzuzu Central Hospital(MCH),daily training for radiographers now includes content on Computed Tomography(CT)image quality control and equipment maintenance to ensure the normal,continuous,and stable operation of the 16-slice spiral CT scanner.Methods:Through comprehensive analysis of relevant equipment,we have identified key parameters that significantly impact CT image quality.Innovative optimization strategies and solutions targeting these parameters have been developed and integrated into daily training programs.Furthermore,starting from an examination of prevalent failure modes observed in CT equipment,we delve into essential maintenance and preservation techniques that CT technologists must master to ensure optimal system performance.Results:(1)Crucial factors affecting CT image quality include artifacts,noise,partial volume effects,and surrounding gap phenomena,alongside spatial and density resolutions,CT dose,reconstruction algorithms,and human factors during the scanning process.In the daily training for radiographers,emphasis is placed on strictly implementing image quality control measures at every stage of the CT scanning process and skillfully applying advanced scanning and image processing techniques.By doing so,we can provide clinicians with accurate and reliable imaging references for diagnosis and treatment.(2)Strategies for CT equipment maintenance:①Environmental inspection of the CT room to ensure cleanliness and hygiene.②Rational and accurate operation,including calibration software proficiency.③Regular maintenance and servicing for minimizing machine downtime.④Maintenance of the CT X-ray tube.CT technicians can become proficient in equipment maintenance and upkeep techniques through training,which can significantly extend the service life of CT systems and reduce the occurrence of malfunctions.Conclusion:Through the regular implementation of rigorous CT image quality control training for radiology technicians,coupled with diligent and proactive CT equipment maintenance,we have observed profound and beneficial impacts on improving image quality.The accuracy and fidelity of radiological data ultimately leads to more accurate diagnoses and effective treatments.
基金supported by grants from the National Natural Science Foundation of China(81301275,81471736 and 81671760)the National Science and Technology Pillar Program during the Twelfth Five-Year Plan Period(2015BAI01B09)Heilongjiang Province Foundation for Returness(LC2013C38)
文摘BACKGROUND： The various combination of multiphase enhancement multislice spiral CT （MSCT） makes the diagno- sis of a small hepatocellular carcinoma （sHCC） on the back- ground of liver cirrhosis possible. This study was to explore whether the combination of MSCT enhancement scan and alpha-fetoprotein （AFP） level ficiency for sHCC. could increase the diagnostic ef- METHODS： This study included 35 sHCC patients and 52 cir- rhotic patients without image evidence of HCC as a control group. The diagnoses were made by three radiologists em- ploying a 5-point rating scale, with postoperative pathologic results as the gold standard. Receiver operating characteristic （ROC） curve analysis was performed to evaluate the diag- nostic value of the three MSCT combination modes （arterial phase＋portal-venous phase, arterial phase＋delayed phase, arterial phase＋portal-venous phase＋delayed phase） and AFP levels for sHCC on the background of liver cirrhosis. RESULTS： The area under ROC curve （AUC）, sensitivity, and specificity of the combination of arterial phase＋portal- venous phase＋delayed phase were 0.93, 93%, and 82%, respectively. The average AUC of the arterial phase＋portal- venous phase＋delayed phase combination was significantly greater than that of the arterial phase＋portal-venous phase （AUC=0.84, P=0.01） and arterial phase＋delayed phase （AUC=0.85, P=0.03）. Arterial phase＋portal-venous phase had a smaller AUC （0.84） than arterial phase＋delayed phase （0.85）, but the difference was insignificant （P=0.15）. After combining MSCT enhancement scan with AFP, the AUC, sensitivity, and specificity were 0.95, 94%, and 83%, respectively, indicating a greatly increased diagnostic efficiency for sHCC. CONCLUSIONS： The combination of AFP and 3 phases MSCT enhancement scan could increase the diagnostic efficiency for sHCC on the background of liver cirrhosis. The application of ROC curve analysis has provided a new method and reference in HCC diagnosis.
文摘目的:分析64排螺旋CT灌注成像(CT perfusion imaging,CTP)参数、血清(Targeting protein for Xenopus kinesin-like protein 2,TPX2)水平与肺癌患者病理特征及预后的相关性。方法:选取2021年6月-2023年11月期间本院收治的77例进行手术治疗的肺癌患者为研究组,另选取同期本院收治的77例良性病变患者为对照组。分析对比两组、不同病理特征及不同预后患者入院时CTP参数及血清TPX2水平,并分析其相关性。结果:研究组入院时参数血容积(Blood volume,BV)、血流量(Blood flow,BF)、通透性(Permeability surface,PMB)及血清TPX2水平均显著高于对照组(P<0.05)。≥3 cm的肿瘤患者参数BF、PMB及血清TPX2水平均显著高于<3 cm肿瘤患者,鳞癌患者参数BF水平显著高于腺癌患者、腺癌患者显著高于其他类型患者,肺癌患者参数BF、BV及血清TPX2水平随分化程度的加重显著升高,低分化>中分化>高分化,Ⅱ期患者参数BF、BV、PMB及血清TPX2水平均显著高于Ⅰ期患者(P<0.05)。预后不良患者入院时CTP参数BF、BV、PMB及血清TPX2水平均显著高于预后良好患者(P<0.05);参数BF、PEI及血清TPX2均与肿瘤大小呈正相关,参数BF与病理类型呈正相关,参数BF、BV及血清TPX2均于分化程度呈负相关,参数BF、BV、PEI及血清TPX2均于TNM分期及预后呈正相关(P<0.05)。结论:CTP参数及血清TPX2水平与肺癌患者病理特征相关,并在一定程度上反映患者预后情况。
