In order to meet people’s demand for various types of network services,researchers have conducted extensive research on authentication schemes for multi-server architecture.Although various schemes have been proposed...In order to meet people’s demand for various types of network services,researchers have conducted extensive research on authentication schemes for multi-server architecture.Although various schemes have been proposed,most of them still have safety defects and fail to meet safety requirements.Recently,Haq et al presented an efficient Hash-based authenticated key agreement scheme for multi-server scheme and claimed that their scheme can withstand all well-known attacks.However,we find that their scheme is vulnerable to replay attack,tracking attack and malicious server impersonation user attack.Then we propose an improved scheme.We also analyze the security of the improved scheme and compare with Haq et al’s scheme in security and computational efficiency.Furthermore,we use the AVISPA(Automated Validation of Internet Security Protocols and Applications)tool to verify the security of the improved scheme.展开更多
During the past decade,rapid advances in wireless communication technologies have made it possible for users to access desired services using hand-held devices.Service providers have hosted multiple servers to ensure ...During the past decade,rapid advances in wireless communication technologies have made it possible for users to access desired services using hand-held devices.Service providers have hosted multiple servers to ensure seamless online services to end-users.To ensure the security of this online communication,researchers have proposed several multi-server authentication schemes incorporating various cryptographic primitives.Due to the low power and computational capacities of mobile devices,the hash-based multi-server authenticated key agreement schemes with offline Registration Server(RS)are the most efficient choice.Recently,Kumar-Om presented such a scheme and proved its security against all renowned attacks.However,we find that their scheme bears an incorrect login phase,and is unsafe to the trace attack,the Session-Specific Temporary Information Attack(SSTIA),and the Key Compromise Impersonation Attack(KCIA).In fact,all of the existing multi-server authentication schemes(hash-based with offline RS)do not withstand KCLA.To deal with this situation,we propose an improved hash-based multi-server authentication scheme(with offline RS).We analyze the security of the proposed scheme under the random oracle model and use the t4Automated Validation of Internet Security Protocols and Applications''(AVISPA)tool.The comparative analysis of communication overhead and computational complexity metrics shows the efficiency of the proposed scheme.展开更多
Since network services are provided cooperatively by multiple servers in the lnternet, the authentication protocols for multiserver architecture are required by Internetbased services, such as online game, online trad...Since network services are provided cooperatively by multiple servers in the lnternet, the authentication protocols for multiserver architecture are required by Internetbased services, such as online game, online trade and so on. Recently, Li et al. analyzed Lee et al.＇s protocol and proposed an improved dynamic identity based authentication protocol for multi-server architecture. They claimed that their protocol provides user＇s anonymity, mutual authentication and the session key agreement against several kinds of attacks. In this paper, a cryptanalysis on Lee et al.＇s scheme shows that Lee et al＇s protocol is also vulnerable to malicious server attack, stolen smart card attack and leak-of-verifier attack. Moreover, Li e/ al.＇s improved protocol is also vulnerable to all these attacks. Further cryptanalysis reveals that Li et al.＇s improved protocol is susceptible to collusion attack.展开更多
Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the del...Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the delivery efficiency,we engineered three artesunate(ART) derivatives,AC_(15)-L(linear),AC_(15)-B(branched),and AC_(15)-C(cyclic) with distinct aliphatic chain architectures.Unexpectedly,we observed that AC_(15)-C exhibited superior cytotoxicity against 4T1 breast cancer cells,and had the highest binding affinity for Lon protease 1(LONP1)(-72.6 kcal/mol).Subsequently,disulfide bond-containing lipid-PEG(DSPESS-PEG2K) modified chain architecture-engineered ART derivatives nanoassemblies(NAs) were developed to mitigate solubility-related limitations while enhancing targeting precision.Molecular docking and experimental validation demonstrated that ART derivatives inhibited LONP1 through hydrophobic interactions while preserved Fe^(2+)-mediated Fenton-like reaction activity.In vitro and in vivo evaluations demonstrated that AC_(15)-C NAs outperformed free ART and other NAs,suppressing 4T1 tumor growth via dual action:LONP1-directed mitochondrial proteostasis collapse and reactive oxygen species(ROS) amplification through Fe^(2+)-ART interactions.This study elucidated a novel anti-tumor mechanism of ART through the rational design of derivatives with spatially configured aliphatic chains,and developed reductionresponsive NAs to provide an advanced delivery strategy.展开更多
Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key componen...Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key component in constructing fault-tolerant systems,particularly in areas such as national security,power networks,and banking private networks.DHR is transforming the cyberspace security industry chain by accommodating a broader range of applications and increasingly capturing the market.However,the development of applications for DHR architecture encounters challenges due to the complexities of handling heterogeneity,managing dynamism,and maintaining usability.To address these issues,we introduce MimicStudio,a comprehensive development framework with a standardized workflow.To our knowledge,MimicStudio is the first effective solution for DHR software development.We present a detailed implementation of MimicStudio with a heterogeneous microcontroller unit project,encompassing three CPUs with different instruction set architectures.The paper evaluates MimicStudio’s support for essential features,including zero-copy synchronization,parallelized build,multi-core collaborative debugging,and dynamic adjustment of the software system’s structure.Our results show that MimicStudio provides a flexible and efficient solution for supporting the dynamic,heterogeneous,and redundant features of fault-tolerant systems.展开更多
Improved yield potential is the goal of barley domestication and cultivation.During this process,two-and six-rowed barley types emerged and have been utilised in breeding and production.The six-rowed type could produc...Improved yield potential is the goal of barley domestication and cultivation.During this process,two-and six-rowed barley types emerged and have been utilised in breeding and production.The six-rowed type could produce three times as many grains as its ancestral two-rowed forms,thus dominating barley cultivation for thousands of years.The deficiens form of the two-rowed type,characterised by extremely suppressed lateral spikelets,has gained dominance over the past few decades in barley-growing regions worldwide.We hypothesised that the absence of lateral spikelets in deficiens barley affects spike architecture and spike-related traits,contributing to its superior yield potential of deficiens barley cultivation.Currently,a deficiens barley variety,RGT Planet,is the most popular barley variety in the world.In this study,we used two F_(2) populations derived from crossing RGT Planet with two canonical two-rowed barley and identified the functional allele Vrs1.t1 associated with deficiens morphology.We observed that the Vrs1.t1 allele may contribute to high yield potential by optimising spike architecture through increased spikelet length,grain number,and grain size.Phylogenetic analysis suggests that the deficiens mutation was likely present from the early stages of barley cultivation in the Fertile Crescent and spread to Ethiopia and beyond with agricultural expansion.We conclude that the ancient deficiens allele Vrs1.t1 has been a critical driver for the recent success of modern barley improvement by optimising spike architecture.展开更多
With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has surged.In this work,a novel gradient-layered architecture was design based on single-pore hollow lignin...With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has surged.In this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable supercapacitors.By depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene lamella.Moreover,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of lignin.All these strategies effectively enhanced the capacitive performance of the electrodes.In addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the electrodes.Flexible electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),respectively.Moreover,their capacitances were well preserved after 1000 times of 600%stretch-release cycling.This study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.展开更多
High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V1...High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V14 stage with three densities(60,000,75,000,and 90,000 plants ha-1,indicated by D1,D2,and D3,respectively)for two seasons.The results showed that the IC-treated wavy canopy featuring both natural height(IC-H)and dwarfed(IC-L)plants,improved light transmission by 8.54%,8.49%,and 16.49%on average than the corresponding controls(CK)at D1,D2,and D3,respectively.The alleviation of canopy crowding stimulated leaf photosynthesis,sugar availability,basal-internode strength,and decreased plant lodging ratios in both IC-H and IC-L,particularly under higher densities.Meanwhile,the IC populations produced significantly higher yield than CK,with an average increase of 3.38%,16.70%,and 15.28%at D1,D2,and D3,respectively.Collectively,this study proposed a new wavy canopy strategy using plant growth retardant to simultaneously increase yield performance and lodging resistance,thus offering a sustainable solution for further development of high-density maize production.展开更多
Modern aircraft tend to use fuel thermal management systems to cool onboard heat sources.However,the design of heat transfer architectures for fuel thermal management systems relies on the experience of the engineers ...Modern aircraft tend to use fuel thermal management systems to cool onboard heat sources.However,the design of heat transfer architectures for fuel thermal management systems relies on the experience of the engineers and lacks theoretical guidance.This paper proposes a concise graph representation method based on graph theory for fuel thermal management systems,which can represent all possible connections between subsystems.A generalized optimization algorithm is proposed for fuel thermal management system architecture to minimize the heat sink.This algorithm can autonomously arrange subsystems with heat production differences and efficiently utilize the architecture of the fuel heat sink.At the same time,two evaluation indices are proposed from the perspective of subsystems.These indices intuitively and clearly show that the reason for the high efficiency of heat sink utilization is the balanced and moderate cooling of each subsystem and verify the rationality of the architecture optimization method.A set of simulations are also conducted,which demonstrate that the fuel tank temperature has no effect on the performance of the architecture.This paper provides a reference for the architectural design of aircraft fuel thermal management systems.The metrics used in this paper can also be utilized to evaluate the existing architecture.展开更多
To address the discrepancies between well and seismic data in stratigraphic correlation of the Triassic Yanchang Formation in the Ordos Basin,NW China,traditional stratigraphic classification schemes,the latest 3D sei...To address the discrepancies between well and seismic data in stratigraphic correlation of the Triassic Yanchang Formation in the Ordos Basin,NW China,traditional stratigraphic classification schemes,the latest 3D seismic and drilling data,and reservoir sections are thoroughly investigated.Guided by the theory of sequence stratigraphy,the progradational sequence stratigraphic framework of the Yanchang Formation is systematically constructed to elucidate new deposition mechanisms in the depressed lacustrine basin,and it has been successfully applied to the exploration and development practices in the Qingcheng Oilfield.Key findings are obtained in three aspects.First,the seismic progradational reflections,marker tuff beds,and condensed sections of flooding surfaces in the Yanchang Formation are consistent and isochronous.Using flooding surface markers as a reference,a progradational sequence stratigraphic architecture is reconstructed for the middle-upper part of Yanchang Formation,and divided into seven clinoform units(CF1-CF7).Second,progradation predominantly occurs in semi-deep to deep lake environments,with the depositional center not always coinciding with the thickest strata.The lacustrine basin underwent an evolution of“oscillatory regression-progradational infilling-multi-phase superimposition”.Third,the case study of Qingcheng Oilfield reveals that the major pay zones consist of“isochronous but heterochronous”gravity-flow sandstone complexes.Guided by the progradational sequence stratigraphic architecture,horizontal well oil-layer penetration rates remain above 82%.The progradational sequence stratigraphic architecture and associated geological insights are more consistent with the sedimentary infilling mechanisms of large-scale continental depressed lacustrine basins and actual drilling results.The research results provide crucial theoretical and technical support for subsequent refined exploration and development of the Yanchang Formation,and are expected to offer a reference for research and production practice in similar continental lacustrine basins.展开更多
It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle acc...It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle access, or human drivers. To mitigate potential risks, this paper provides the inauguration study by proposing a theoretical framework in the physical, human and cyber triad. Its goal is to, at each time point, detect adversary control behaviors and protect control systems against malicious operations via integrating a variety of methods. This paper only proposes a theoretical framework which tries to indicate possible threats. With the support of the framework, the security system can lightly reduce the risk. The development and implementation of the system are out of scope.展开更多
Not always climate and cultural contexts are discussed at the forefront of architectural discussions on traditional or vernacular architecture,nevertheless,the construction material also plays a significant part in de...Not always climate and cultural contexts are discussed at the forefront of architectural discussions on traditional or vernacular architecture,nevertheless,the construction material also plays a significant part in defining places’architectural languages.Building from the local materials is an essential ingredient of the local distinctiveness,whilst forming the architectural grand gesture in its context.In Siwa oasis,salt architecture has formed that architectural grand gesture.The vernacular vocabularies adopted by old Bedouins using salt bricks generated Siwa’s unique spirit.In this paper,some examples are illustrated based on a series of site visits to three main sites in Siwa,namely:Old Shali,Abu Shuruf,and Aghourmy.This shows the evolution of Siwa’s vernacular architecture and the role of the architectural language or detrimental effect on the overall quality of architecture.From the site visits,it was observed that building with the traditional technique is now becoming abandoned in Siwa,explained by the local builders to be due to the huge costs required;forcing them to shifting to modern architecture.The influx to building using modern techniques has led to a significant transformation in the urban morphology and spirit of Siwa.Herein lies the scope of this paper:to discuss the impact of the evolution of vernacular architecture on the overall quality of architecture in Siwa and thus identifying the problems which will lead to policy formulation and guidelines for the redevelopment of Siwa in order to“revitalize/resuscitate”its vernacular style accordingly.展开更多
This paper adopts the Global Workspace Theory as a neuro-scientifically plausible theory for developing conscious cognitive architecture.The Global Workspace Theory’s compatibility with the working mechanisms underne...This paper adopts the Global Workspace Theory as a neuro-scientifically plausible theory for developing conscious cognitive architecture.The Global Workspace Theory’s compatibility with the working mechanisms underneath human brains is enhanced by the implementation of different cognitive features based on this framework.Amongst the topics in the literature for intelligent systems,we start with attention,memory and learning mechanisms,and corresponding experiments are summarized here.We also discuss how other topics of cognitive robotics could be developed based on these three basic components,and their correlations.This provides a foundation for future long-term development of cognitive architectures of cognitive robots.The research in this paper follows the incremental research pathway for the architecture implementation,which is consistent with the Biologically Inspired Cognitive Architecture roadmap.展开更多
A restoration concept has been developed based on the Baiyun Taoist Temple Map found in the Continuation of the Gaolan County Annals.This study systematically analyzes the architectural features of Baiyun Taoist Templ...A restoration concept has been developed based on the Baiyun Taoist Temple Map found in the Continuation of the Gaolan County Annals.This study systematically analyzes the architectural features of Baiyun Taoist Temple in Lanzhou during the Daoguang period of the Qing Dynasty from three perspectives:overall layout,spatial design,and garden artistic conception.The analysis offers a representative case for understanding the spatial organization principles and cultural connotation of Taoist architecture in the Lanzhou region during the Qing Dynasty.展开更多
The aim of this article is to present my interpretation of the holistic-phenomenological worldview in practice.This study demonstrates how this approach,as well as the planning process that I followed(a process fundam...The aim of this article is to present my interpretation of the holistic-phenomenological worldview in practice.This study demonstrates how this approach,as well as the planning process that I followed(a process fundamentally different from conventional ones)was implemented in a residential neighborhood I designed and built in the social,economic,and physical structure of the collective known in Israel as a‘kibbutz’.The intention is to raise a broad public discussion and pose a challenge to 21st-century architecture regarding how to intervene in a moral and human way within an existing environment,urban or natural,which must be respected and preserved,when integrating within it a new contemporary architecture.展开更多
Overview of root system architecture.The plant root system is a highly dynamic and multifunctional organ system composed of primary roots,lateral roots,adventitious roots,and root hairs.Based on topological morphology...Overview of root system architecture.The plant root system is a highly dynamic and multifunctional organ system composed of primary roots,lateral roots,adventitious roots,and root hairs.Based on topological morphology,root systems can be classified as taproot systems or fibrous root systems.Root system architecture(RSA)refers to the spatial distribution and extension patterns of roots within soil,encompassing characteristics such as root length,branching angle,density,and spatial arrangement.RSA not only determines the plant’s capacity to acquire water and nutrients but also influences other root functions,playing a decisive role in overall plant health.展开更多
Traditional architecture,as a crucial component of human cultural heritage,conveys significant historical context and cultural significance while reflecting regional traits and national identity.Nevertheless,in the fa...Traditional architecture,as a crucial component of human cultural heritage,conveys significant historical context and cultural significance while reflecting regional traits and national identity.Nevertheless,in the face of rapid modernization,traditional architecture is encountering challenges on an unprecedented scale.This study focuses on examining the strategies for preserving and transforming traditional architecture.By evaluating the importance,issues,and obstacles associated with safeguarding traditional architecture,this paper seeks to propose effective and rational conservation approaches and transformation techniques,ultimately aiming to ensure the sustainable development and cultural continuity of traditional architecture.展开更多
This paper explores the collaborative management model of construction technology and plant beautification strategies in landscape architecture site management.It analyzes the key aspects of construction technology an...This paper explores the collaborative management model of construction technology and plant beautification strategies in landscape architecture site management.It analyzes the key aspects of construction technology and the implementation points of plant beautification strategies,constructs a synergy mechanism between technology and strategy,and proposes a dynamic adjustment and multi-professional collaboration model.The effectiveness of this model is verified through practical case studies,providing theoretical support and practical references for the refined construction of landscape architecture.展开更多
This paper introduces a computational cognitive architecture that serves as a comprehensive computational theory of the human mind,from cognitive science and computational psychology.The cognitive architecture(named C...This paper introduces a computational cognitive architecture that serves as a comprehensive computational theory of the human mind,from cognitive science and computational psychology.The cognitive architecture(named Clarion)has been justified by,and validated against,psychological data,findings,and theoretical constructs.One important theoretical background for it is the dual-process theories,which led to its overall two-level structuring in a hybrid neuro-symbolic way.Furthermore,given the recent advances in AI and computing technology,LLMs are being incorporated into the model to better capture human intuition and instinct(and implicit processes in general),in order to further enhance Clarion.Integrating Clarion and LLMs can also help to develop AI systems that are more capable,more reliable,and more human-like.Overall,the paper advocates a multidisciplinary approach towards developing better models for cognitive science and for AI.展开更多
Focusing on the digital evaluation of classroom teaching quality in private colleges and universities,an indicator model of“teaching subject-teaching object-teaching effect”for the landscape architecture major of Ch...Focusing on the digital evaluation of classroom teaching quality in private colleges and universities,an indicator model of“teaching subject-teaching object-teaching effect”for the landscape architecture major of Chongqing College of Humanities,Science&Technology was constructed.By using methods such as Delphi,AHP,Likert and questionnaire survey,the teaching quality of 8 courses of landscape architecture major was evaluated.The results show that the average score of the indicators is 2.8776,indicating that the overall improvement space for the teaching quality of the sample professional courses is relatively large,and the key shortcomings are students’learning interest and initiative,the application and transformation of professional knowledge,as well as the cultivation of innovation and practical ability.The research verified the scientific nature and discrimination of the model,and put forward suggestions for the precise improvement of classroom atmosphere,assignment design and ability cultivation driven by data,thereby providing a replicable model for the digital evaluation and teaching quality improvement of engineering majors in private colleges and universities.展开更多
基金Supported by the Applied Basic and Advanced Technology Research Programs of Tianjin(15JCYBJC15900)。
文摘In order to meet people’s demand for various types of network services,researchers have conducted extensive research on authentication schemes for multi-server architecture.Although various schemes have been proposed,most of them still have safety defects and fail to meet safety requirements.Recently,Haq et al presented an efficient Hash-based authenticated key agreement scheme for multi-server scheme and claimed that their scheme can withstand all well-known attacks.However,we find that their scheme is vulnerable to replay attack,tracking attack and malicious server impersonation user attack.Then we propose an improved scheme.We also analyze the security of the improved scheme and compare with Haq et al’s scheme in security and computational efficiency.Furthermore,we use the AVISPA(Automated Validation of Internet Security Protocols and Applications)tool to verify the security of the improved scheme.
文摘During the past decade,rapid advances in wireless communication technologies have made it possible for users to access desired services using hand-held devices.Service providers have hosted multiple servers to ensure seamless online services to end-users.To ensure the security of this online communication,researchers have proposed several multi-server authentication schemes incorporating various cryptographic primitives.Due to the low power and computational capacities of mobile devices,the hash-based multi-server authenticated key agreement schemes with offline Registration Server(RS)are the most efficient choice.Recently,Kumar-Om presented such a scheme and proved its security against all renowned attacks.However,we find that their scheme bears an incorrect login phase,and is unsafe to the trace attack,the Session-Specific Temporary Information Attack(SSTIA),and the Key Compromise Impersonation Attack(KCIA).In fact,all of the existing multi-server authentication schemes(hash-based with offline RS)do not withstand KCLA.To deal with this situation,we propose an improved hash-based multi-server authentication scheme(with offline RS).We analyze the security of the proposed scheme under the random oracle model and use the t4Automated Validation of Internet Security Protocols and Applications''(AVISPA)tool.The comparative analysis of communication overhead and computational complexity metrics shows the efficiency of the proposed scheme.
基金supported by the Key Program of NSFC-Guangdong Union Foundation under Grant No.U1135002Young Foundation of Humanities and Social Sciences of MOE (Ministry of Education in China) of under Grant No.11YJCZH160Foundation for Young Scientists of Jiangxi Province of China under Grant No.20133BCB23016
文摘Since network services are provided cooperatively by multiple servers in the lnternet, the authentication protocols for multiserver architecture are required by Internetbased services, such as online game, online trade and so on. Recently, Li et al. analyzed Lee et al.＇s protocol and proposed an improved dynamic identity based authentication protocol for multi-server architecture. They claimed that their protocol provides user＇s anonymity, mutual authentication and the session key agreement against several kinds of attacks. In this paper, a cryptanalysis on Lee et al.＇s scheme shows that Lee et al＇s protocol is also vulnerable to malicious server attack, stolen smart card attack and leak-of-verifier attack. Moreover, Li e/ al.＇s improved protocol is also vulnerable to all these attacks. Further cryptanalysis reveals that Li et al.＇s improved protocol is susceptible to collusion attack.
基金financially supported by the Liaoning Revitalization Talents Program (No.XLYC2403107)the Excellent Youth Science Foundation of Liaoning Province (No.2024JH3/10200046)the Basic Scientific Research Project of Liaoning Provincial Department of Education (No.LJ212410163015)。
文摘Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the delivery efficiency,we engineered three artesunate(ART) derivatives,AC_(15)-L(linear),AC_(15)-B(branched),and AC_(15)-C(cyclic) with distinct aliphatic chain architectures.Unexpectedly,we observed that AC_(15)-C exhibited superior cytotoxicity against 4T1 breast cancer cells,and had the highest binding affinity for Lon protease 1(LONP1)(-72.6 kcal/mol).Subsequently,disulfide bond-containing lipid-PEG(DSPESS-PEG2K) modified chain architecture-engineered ART derivatives nanoassemblies(NAs) were developed to mitigate solubility-related limitations while enhancing targeting precision.Molecular docking and experimental validation demonstrated that ART derivatives inhibited LONP1 through hydrophobic interactions while preserved Fe^(2+)-mediated Fenton-like reaction activity.In vitro and in vivo evaluations demonstrated that AC_(15)-C NAs outperformed free ART and other NAs,suppressing 4T1 tumor growth via dual action:LONP1-directed mitochondrial proteostasis collapse and reactive oxygen species(ROS) amplification through Fe^(2+)-ART interactions.This study elucidated a novel anti-tumor mechanism of ART through the rational design of derivatives with spatially configured aliphatic chains,and developed reductionresponsive NAs to provide an advanced delivery strategy.
基金supported by National Key Research and Development Program of China(No.2023YFB 4404200).
文摘Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key component in constructing fault-tolerant systems,particularly in areas such as national security,power networks,and banking private networks.DHR is transforming the cyberspace security industry chain by accommodating a broader range of applications and increasingly capturing the market.However,the development of applications for DHR architecture encounters challenges due to the complexities of handling heterogeneity,managing dynamism,and maintaining usability.To address these issues,we introduce MimicStudio,a comprehensive development framework with a standardized workflow.To our knowledge,MimicStudio is the first effective solution for DHR software development.We present a detailed implementation of MimicStudio with a heterogeneous microcontroller unit project,encompassing three CPUs with different instruction set architectures.The paper evaluates MimicStudio’s support for essential features,including zero-copy synchronization,parallelized build,multi-core collaborative debugging,and dynamic adjustment of the software system’s structure.Our results show that MimicStudio provides a flexible and efficient solution for supporting the dynamic,heterogeneous,and redundant features of fault-tolerant systems.
基金Funding for this research was provided by the Australia Grain Research and Development Corporation(9176507)the Western Crop Genetics Alliance.Jingye Cheng thanks The University of Tasmania,Australia for the scholarship(495802)。
文摘Improved yield potential is the goal of barley domestication and cultivation.During this process,two-and six-rowed barley types emerged and have been utilised in breeding and production.The six-rowed type could produce three times as many grains as its ancestral two-rowed forms,thus dominating barley cultivation for thousands of years.The deficiens form of the two-rowed type,characterised by extremely suppressed lateral spikelets,has gained dominance over the past few decades in barley-growing regions worldwide.We hypothesised that the absence of lateral spikelets in deficiens barley affects spike architecture and spike-related traits,contributing to its superior yield potential of deficiens barley cultivation.Currently,a deficiens barley variety,RGT Planet,is the most popular barley variety in the world.In this study,we used two F_(2) populations derived from crossing RGT Planet with two canonical two-rowed barley and identified the functional allele Vrs1.t1 associated with deficiens morphology.We observed that the Vrs1.t1 allele may contribute to high yield potential by optimising spike architecture through increased spikelet length,grain number,and grain size.Phylogenetic analysis suggests that the deficiens mutation was likely present from the early stages of barley cultivation in the Fertile Crescent and spread to Ethiopia and beyond with agricultural expansion.We conclude that the ancient deficiens allele Vrs1.t1 has been a critical driver for the recent success of modern barley improvement by optimising spike architecture.
基金supported by Natural Science and Engineering Research Council of Canada(RGPIN-2017-06737)Canada Research Chairs program,the National Key Research and Development Program of China(2017YFD0601005,2022YFD0904201)+1 种基金the National Natural Science Foundation of China(51203075)the China Scholarship Council(Grant No.CSC202208320361).
文摘With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has surged.In this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable supercapacitors.By depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene lamella.Moreover,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of lignin.All these strategies effectively enhanced the capacitive performance of the electrodes.In addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the electrodes.Flexible electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),respectively.Moreover,their capacitances were well preserved after 1000 times of 600%stretch-release cycling.This study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.
基金supported by the National Key Research and Development Program of China(2023YFD2303302,2022YFD2300803)the National Natural Science Foundation of China(32160445)the China Agriculture Research System of MOF and MARA(CARS-02-16).
文摘High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V14 stage with three densities(60,000,75,000,and 90,000 plants ha-1,indicated by D1,D2,and D3,respectively)for two seasons.The results showed that the IC-treated wavy canopy featuring both natural height(IC-H)and dwarfed(IC-L)plants,improved light transmission by 8.54%,8.49%,and 16.49%on average than the corresponding controls(CK)at D1,D2,and D3,respectively.The alleviation of canopy crowding stimulated leaf photosynthesis,sugar availability,basal-internode strength,and decreased plant lodging ratios in both IC-H and IC-L,particularly under higher densities.Meanwhile,the IC populations produced significantly higher yield than CK,with an average increase of 3.38%,16.70%,and 15.28%at D1,D2,and D3,respectively.Collectively,this study proposed a new wavy canopy strategy using plant growth retardant to simultaneously increase yield performance and lodging resistance,thus offering a sustainable solution for further development of high-density maize production.
文摘Modern aircraft tend to use fuel thermal management systems to cool onboard heat sources.However,the design of heat transfer architectures for fuel thermal management systems relies on the experience of the engineers and lacks theoretical guidance.This paper proposes a concise graph representation method based on graph theory for fuel thermal management systems,which can represent all possible connections between subsystems.A generalized optimization algorithm is proposed for fuel thermal management system architecture to minimize the heat sink.This algorithm can autonomously arrange subsystems with heat production differences and efficiently utilize the architecture of the fuel heat sink.At the same time,two evaluation indices are proposed from the perspective of subsystems.These indices intuitively and clearly show that the reason for the high efficiency of heat sink utilization is the balanced and moderate cooling of each subsystem and verify the rationality of the architecture optimization method.A set of simulations are also conducted,which demonstrate that the fuel tank temperature has no effect on the performance of the architecture.This paper provides a reference for the architectural design of aircraft fuel thermal management systems.The metrics used in this paper can also be utilized to evaluate the existing architecture.
基金Supported by the National Science and Technology Major Project(2017ZX05001)CNPC Technology Project(2023YQX20111).
文摘To address the discrepancies between well and seismic data in stratigraphic correlation of the Triassic Yanchang Formation in the Ordos Basin,NW China,traditional stratigraphic classification schemes,the latest 3D seismic and drilling data,and reservoir sections are thoroughly investigated.Guided by the theory of sequence stratigraphy,the progradational sequence stratigraphic framework of the Yanchang Formation is systematically constructed to elucidate new deposition mechanisms in the depressed lacustrine basin,and it has been successfully applied to the exploration and development practices in the Qingcheng Oilfield.Key findings are obtained in three aspects.First,the seismic progradational reflections,marker tuff beds,and condensed sections of flooding surfaces in the Yanchang Formation are consistent and isochronous.Using flooding surface markers as a reference,a progradational sequence stratigraphic architecture is reconstructed for the middle-upper part of Yanchang Formation,and divided into seven clinoform units(CF1-CF7).Second,progradation predominantly occurs in semi-deep to deep lake environments,with the depositional center not always coinciding with the thickest strata.The lacustrine basin underwent an evolution of“oscillatory regression-progradational infilling-multi-phase superimposition”.Third,the case study of Qingcheng Oilfield reveals that the major pay zones consist of“isochronous but heterochronous”gravity-flow sandstone complexes.Guided by the progradational sequence stratigraphic architecture,horizontal well oil-layer penetration rates remain above 82%.The progradational sequence stratigraphic architecture and associated geological insights are more consistent with the sedimentary infilling mechanisms of large-scale continental depressed lacustrine basins and actual drilling results.The research results provide crucial theoretical and technical support for subsequent refined exploration and development of the Yanchang Formation,and are expected to offer a reference for research and production practice in similar continental lacustrine basins.
文摘It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle access, or human drivers. To mitigate potential risks, this paper provides the inauguration study by proposing a theoretical framework in the physical, human and cyber triad. Its goal is to, at each time point, detect adversary control behaviors and protect control systems against malicious operations via integrating a variety of methods. This paper only proposes a theoretical framework which tries to indicate possible threats. With the support of the framework, the security system can lightly reduce the risk. The development and implementation of the system are out of scope.
文摘Not always climate and cultural contexts are discussed at the forefront of architectural discussions on traditional or vernacular architecture,nevertheless,the construction material also plays a significant part in defining places’architectural languages.Building from the local materials is an essential ingredient of the local distinctiveness,whilst forming the architectural grand gesture in its context.In Siwa oasis,salt architecture has formed that architectural grand gesture.The vernacular vocabularies adopted by old Bedouins using salt bricks generated Siwa’s unique spirit.In this paper,some examples are illustrated based on a series of site visits to three main sites in Siwa,namely:Old Shali,Abu Shuruf,and Aghourmy.This shows the evolution of Siwa’s vernacular architecture and the role of the architectural language or detrimental effect on the overall quality of architecture.From the site visits,it was observed that building with the traditional technique is now becoming abandoned in Siwa,explained by the local builders to be due to the huge costs required;forcing them to shifting to modern architecture.The influx to building using modern techniques has led to a significant transformation in the urban morphology and spirit of Siwa.Herein lies the scope of this paper:to discuss the impact of the evolution of vernacular architecture on the overall quality of architecture in Siwa and thus identifying the problems which will lead to policy formulation and guidelines for the redevelopment of Siwa in order to“revitalize/resuscitate”its vernacular style accordingly.
基金Supported by the European Union’s Horizon Europe research and innovation program(101120727-PRIMI).
文摘This paper adopts the Global Workspace Theory as a neuro-scientifically plausible theory for developing conscious cognitive architecture.The Global Workspace Theory’s compatibility with the working mechanisms underneath human brains is enhanced by the implementation of different cognitive features based on this framework.Amongst the topics in the literature for intelligent systems,we start with attention,memory and learning mechanisms,and corresponding experiments are summarized here.We also discuss how other topics of cognitive robotics could be developed based on these three basic components,and their correlations.This provides a foundation for future long-term development of cognitive architectures of cognitive robots.The research in this paper follows the incremental research pathway for the architecture implementation,which is consistent with the Biologically Inspired Cognitive Architecture roadmap.
文摘A restoration concept has been developed based on the Baiyun Taoist Temple Map found in the Continuation of the Gaolan County Annals.This study systematically analyzes the architectural features of Baiyun Taoist Temple in Lanzhou during the Daoguang period of the Qing Dynasty from three perspectives:overall layout,spatial design,and garden artistic conception.The analysis offers a representative case for understanding the spatial organization principles and cultural connotation of Taoist architecture in the Lanzhou region during the Qing Dynasty.
文摘The aim of this article is to present my interpretation of the holistic-phenomenological worldview in practice.This study demonstrates how this approach,as well as the planning process that I followed(a process fundamentally different from conventional ones)was implemented in a residential neighborhood I designed and built in the social,economic,and physical structure of the collective known in Israel as a‘kibbutz’.The intention is to raise a broad public discussion and pose a challenge to 21st-century architecture regarding how to intervene in a moral and human way within an existing environment,urban or natural,which must be respected and preserved,when integrating within it a new contemporary architecture.
文摘Overview of root system architecture.The plant root system is a highly dynamic and multifunctional organ system composed of primary roots,lateral roots,adventitious roots,and root hairs.Based on topological morphology,root systems can be classified as taproot systems or fibrous root systems.Root system architecture(RSA)refers to the spatial distribution and extension patterns of roots within soil,encompassing characteristics such as root length,branching angle,density,and spatial arrangement.RSA not only determines the plant’s capacity to acquire water and nutrients but also influences other root functions,playing a decisive role in overall plant health.
文摘Traditional architecture,as a crucial component of human cultural heritage,conveys significant historical context and cultural significance while reflecting regional traits and national identity.Nevertheless,in the face of rapid modernization,traditional architecture is encountering challenges on an unprecedented scale.This study focuses on examining the strategies for preserving and transforming traditional architecture.By evaluating the importance,issues,and obstacles associated with safeguarding traditional architecture,this paper seeks to propose effective and rational conservation approaches and transformation techniques,ultimately aiming to ensure the sustainable development and cultural continuity of traditional architecture.
文摘This paper explores the collaborative management model of construction technology and plant beautification strategies in landscape architecture site management.It analyzes the key aspects of construction technology and the implementation points of plant beautification strategies,constructs a synergy mechanism between technology and strategy,and proposes a dynamic adjustment and multi-professional collaboration model.The effectiveness of this model is verified through practical case studies,providing theoretical support and practical references for the refined construction of landscape architecture.
文摘This paper introduces a computational cognitive architecture that serves as a comprehensive computational theory of the human mind,from cognitive science and computational psychology.The cognitive architecture(named Clarion)has been justified by,and validated against,psychological data,findings,and theoretical constructs.One important theoretical background for it is the dual-process theories,which led to its overall two-level structuring in a hybrid neuro-symbolic way.Furthermore,given the recent advances in AI and computing technology,LLMs are being incorporated into the model to better capture human intuition and instinct(and implicit processes in general),in order to further enhance Clarion.Integrating Clarion and LLMs can also help to develop AI systems that are more capable,more reliable,and more human-like.Overall,the paper advocates a multidisciplinary approach towards developing better models for cognitive science and for AI.
基金Sponsored by the Research Project of Higher Education(Undergraduate)Teaching Reform of Chongqing Municipal Education Commission in 2025(253272)Key Project of Educational Reform of Chongqing College of Humanities,Science&Technology(23CRKXJJG08).
文摘Focusing on the digital evaluation of classroom teaching quality in private colleges and universities,an indicator model of“teaching subject-teaching object-teaching effect”for the landscape architecture major of Chongqing College of Humanities,Science&Technology was constructed.By using methods such as Delphi,AHP,Likert and questionnaire survey,the teaching quality of 8 courses of landscape architecture major was evaluated.The results show that the average score of the indicators is 2.8776,indicating that the overall improvement space for the teaching quality of the sample professional courses is relatively large,and the key shortcomings are students’learning interest and initiative,the application and transformation of professional knowledge,as well as the cultivation of innovation and practical ability.The research verified the scientific nature and discrimination of the model,and put forward suggestions for the precise improvement of classroom atmosphere,assignment design and ability cultivation driven by data,thereby providing a replicable model for the digital evaluation and teaching quality improvement of engineering majors in private colleges and universities.
