A new scheme of super-resolution optical fluctuation imaging(SOFI)is proposed to broaden its application in the high-order cumulant reconstruction by optimizing blinking characteristics,eliminating noise in raw data a...A new scheme of super-resolution optical fluctuation imaging(SOFI)is proposed to broaden its application in the high-order cumulant reconstruction by optimizing blinking characteristics,eliminating noise in raw data and applying multi-resolution analysis in cumulant reconstruction.A motor-driven rotating mask optical modulation system is designed to adjust the excitation lightfield and allows for fast deployment.Active-modulated fluorescence fluctuation superresolution microscopy with multi-resolution analysis(AMF-MRA-SOFI)demonstrates enhanced resolution ability and reconstruction quality in experiments performed on sample of conventional dyes,achieving a resolution of 100 nm in the fourth order compared to conventional SOFI reconstruction.Furthermore,our approach combining expansion super-resolution achieved a resolution at-57 nm.展开更多
A multi-resolution smoothed particle hydrodynamics and peridynamics(SPH-PD)coupling model is proposed in this study for simulating the fracture characteristics of ice plates exposed to underwater blast loads.The SPH m...A multi-resolution smoothed particle hydrodynamics and peridynamics(SPH-PD)coupling model is proposed in this study for simulating the fracture characteristics of ice plates exposed to underwater blast loads.The SPH model employs a volume adaptive scheme(VAS)and a multi-resolution particle technique to accurately simulate explosive charge detonation and shock wave propagation.This approach addresses numerical challenges from charge expansion and significant size disparity between the charge and the fluid particles.The model captures the full underwater explosion process,covering both the shock wave phase and the bubble expansion stage,by applying appropriate equations of state for each respective phase.To analyze ice plate damage and crack propagation influenced by temperature changes,an ordinary state-based PD(OSB-PD)formulation with coupled mechanical and thermodynamic models is used.Numerical results show that the proposed coupling method demonstrates good agreement with reference solutions and experimental data.展开更多
This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although ...This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.展开更多
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.展开更多
Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,thi...Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.展开更多
Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practic...Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.展开更多
Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomed...Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.展开更多
The discharge of micro-polluted water from sources such as agricultural runoff,urban stormwater,and treated effluents presents significant challenges to aquatic ecosystems.Constructed wetlands(CWs)have gained recog-ni...The discharge of micro-polluted water from sources such as agricultural runoff,urban stormwater,and treated effluents presents significant challenges to aquatic ecosystems.Constructed wetlands(CWs)have gained recog-nition as an eco-friendly solution for removing pollutants from various wastewater sources and are increasingly applied for micro-polluted water treatment.By reviewing 78 full-scale CW studies from Web of Science,it is summarized that the ranges of ammonium nitrogen(NH4+-N)concentrations in runoff,wastewater treatment plant effluent and polluted river were 0.1–6.6,0.3–12.3,and 0.2–41.1 mg/L,respectively.The ranges of ni-trate nitrogen concentrations were 0.2–14.2,0–5.7,and 0–2.6 mg/L,respectively.Removal efficiencies of CWs for micro-polluted water varied by CW types.The total nitrogen removal efficiencies for subsurface-flow CWs,free-water surface-flow CWs,and hybrid CWs ranged from 27.4%to 66.5%,16.8%to 89.8%,and 19.4%to 88.2%,respectively.The NH4+-N removal efficiencies ranged from 34.2%to 73.6%,38.4%to 89.4%and 13.5%to 94.2%,respectively.Additionally,other factors influencing contaminant removal efficiency such as hydraulic retention time,vegetation types,redox micro-environment and influent water quality were evaluated.Based on these findings,two strategies for improving the purification performance of CWs were proposed:the selection of incorporating electron donor substrates and the optimization of operation parameters.This paper serves as a synthesis of information to guide future research and full-scale CW applications in micro-polluted water treatment.展开更多
Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespr...Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespread attention for CO_(2)RR due to their high catalytic activity,selectivity,excellent stability,and low cost.However,they still need to be further improved to meet the needs of industrial applications.This review article comprehensively summarizes the recent advances in regulation strategies of Bi-based catalysts and can be divided into six categories:(1)defect engineering,(2)atomic doping engineering,(3)organic framework engineering,(4)inorganic heterojunction engineering,(5)crystal face engineering,and(6)alloying and polarization engineering.Meanwhile,the corresponding catalytic mechanisms of each regulation strategy will also be discussed in detail,aiming to enable researchers to understand the structure-property relationship of the improved Bibased catalysts fundamentally.Finally,the challenges and future opportunities of the Bi-based catalysts in the photoelectrocatalytic CO_(2)RR application field will also be featured from the perspectives of the(1)combination or synergy of multiple regulatory strategies,(2)revealing formation mechanism and realizing controllable synthesis,and(3)in situ multiscale investigation of activation pathways and uncovering the catalytic mechanisms.On the one hand,through the comparative analysis and mechanism explanation of the six major regulatory strategies,a multidimensional knowledge framework of the structure-activity relationship of Bi-based catalysts can be constructed for researchers,which not only deepens the atomic-level understanding of catalytic active sites,charge transport paths,and the adsorption behavior of intermediate products,but also provides theoretical guiding principles for the controllable design of new catalysts;on the other hand,the promising collaborative regulation strategies,controllable synthetic paths,and the in situ multiscale characterization techniques presented in this work provides a paradigm reference for shortening the research and development cycle of high-performance catalysts,conducive to facilitating the transition of photoelectrocatalytic CO_(2)RR technology from the laboratory routes to industrial application.展开更多
In this study, we used the multi-resolution graph-based clustering （MRGC） method for determining the electrofacies （EF） and lithofacies （LF） from well log data obtained from the intraplatform bank gas fields loc...In this study, we used the multi-resolution graph-based clustering （MRGC） method for determining the electrofacies （EF） and lithofacies （LF） from well log data obtained from the intraplatform bank gas fields located in the Amu Darya Basin. The MRGC could automatically determine the optimal number of clusters without prior knowledge about the structure or cluster numbers of the analyzed data set and allowed the users to control the level of detail actually needed to define the EF. Based on the LF identification and successful EF calibration using core data, an MRGC EF partition model including five clusters and a quantitative LF interpretation chart were constructed. The EF clusters 1 to 5 were interpreted as lagoon, anhydrite flat, interbank, low-energy bank, and high-energy bank, and the coincidence rate in the cored interval could reach 85%. We concluded that the MRGC could be accurately applied to predict the LF in non-cored but logged wells. Therefore, continuous EF clusters were partitioned and corresponding LF were characteristics ＆different LF were analyzed interpreted, and the distribution and petrophysical in the framework of sequence stratigraphy.展开更多
Timely crop acreage and distribution information are the basic data which drive many agriculture related applications.For identifying crop types based on remote sensing,methods using only a single image type have sign...Timely crop acreage and distribution information are the basic data which drive many agriculture related applications.For identifying crop types based on remote sensing,methods using only a single image type have significant limitations.Current research that integrates fine and coarser spatial resolution images,using techniques such as unmixing methods,regression models,and others,usually results in coarse resolution abundance without sufficient detail within pixels,and limited attention has been paid to the spatial relationship between the pixels from these two kinds of images.Here we propose a new solution to identify winter wheat by integrating spectral and temporal information derived from multi-resolution remote sensing data and determine the spatial distribution of sub-pixels within the coarse resolution pixels.Firstly,the membership of pixels which belong to winter wheat is calculated using a 25-m resolution resampled Landsat Thematic Mapper(TM)image based on the Bayesian equation.Then,the winter wheat abundance(acreage fraction in a pixel)is assessed by using a multiple regression model based on the unique temporal change features from moderate resolution imaging spectroradiometer(MODIS)time series data.Finally,winter wheat is identified by the proposed Abundance-Membership(AM)model based on the spatial relationship between the two types of pixels.Specifically,winter wheat is identified by comparing the spatially corresponding 10×10 membership pixels of each abundance pixel.In other words,this method takes advantage of the relative size of membership in a local space,rather than the absolute size in the entire study area.This method is tested in the major agricultural area of Yiluo Basin,China,and the results show that acreage accuracy(Aa)is 93.01%and sampling accuracy(As)is 91.40%.Confusion matrix shows that overall accuracy(OA)is 91.4%and the kappa coefficient(Kappa)is 0.755.These values are significantly improved compared to the traditional Maximum Likelihood classification(MLC)and Random Forest classification(RFC)which rely on spectral features.The results demonstrate that the identification accuracy can be improved by integrating spectral and temporal information.Since the identification of winter wheat is performed in the space corresponding to each MODIS pixel,the influence of differences of environmental conditions is greatly reduced.This advantage allows the proposed method to be effectively applied in other places.展开更多
Mixture model based image segmentation method, which assumes that image pixels are independent and do not consider the position relationship between pixels, is not robust to noise and usually leads to misclassificatio...Mixture model based image segmentation method, which assumes that image pixels are independent and do not consider the position relationship between pixels, is not robust to noise and usually leads to misclassification. A new segmentation method, called multi-resolution Ganssian mixture model method, is proposed. First, an image pyramid is constructed and son-father link relationship is built between each level of pyramid. Then the mixture model segmentation method is applied to the top level. The segmentation result on the top level is passed top-down to the bottom level according to the son-father link relationship between levels. The proposed method considers not only local but also global information of image, it overcomes the effect of noise and can obtain better segmentation result. Experimental result demonstrates its effectiveness.展开更多
Huge calculation burden and difficulty in convergence are the two central conundrums of nonlinear topology optimization(NTO).To this end,a multi-resolution nonlinear topology optimization(MR-NTO)method is proposed bas...Huge calculation burden and difficulty in convergence are the two central conundrums of nonlinear topology optimization(NTO).To this end,a multi-resolution nonlinear topology optimization(MR-NTO)method is proposed based on the multiresolution design strategy(MRDS)and the additive hyperelasticity technique(AHT),taking into account the geometric nonlinearity and material nonlinearity.The MR-NTO strategy is established in the framework of the solid isotropic material with penalization(SIMP)method,while the Neo-Hookean hyperelastic material model characterizes the material nonlinearity.The coarse analysis grid is employed for finite element(FE)calculation,and the fine material grid is applied to describe the material configuration.To alleviate the convergence problem and reduce sensitivity calculation complexity,the software ANSYS coupled with AHT is utilized to perform the nonlinear FE calculation.A strategy for redistributing strain energy is proposed during the sensitivity analysis,i.e.,transforming the strain energy of the analysis element into that of the material element,including Neo-Hooken and second-order Yeoh material.Numerical examples highlight three distinct advantages of the proposed method,i.e.,it can(1)significantly improve the computational efficiency,(2)make up for the shortcoming that NTO based on AHT may have difficulty in convergence when solving the NTO problem,especially for 3D problems,(3)successfully cope with high-resolution 3D complex NTO problems on a personal computer.展开更多
Multi-sensor image registration has been widely used in remote sensing and medical image field, but registration performance is degenerated when heterogeneous images are involved. An image registration method based on...Multi-sensor image registration has been widely used in remote sensing and medical image field, but registration performance is degenerated when heterogeneous images are involved. An image registration method based on multi-resolution shape analysis is proposed in this paper, to deal with the problem that the shape of similar objects is always invariant. The contours of shapes are first detected as visual features using an extended contour search algorithm in order to reduce effects of noise, and the multi-resolution shape descriptor is constructed through Fourier curvature representation of the contour’s chain code. Then a minimum distance function is used to judge the similarity between two contours. To avoid the effect of different resolution and intensity distribution, suitable resolution of each image is selected by maximizing the consistency of its pyramid shapes. Finally, the transformation parameters are estimated based on the matched control-point pairs which are the centers of gravity of the closed contours. Multi-sensor Landsat TM imagery and infrared imagery have been used as experimental data for comparison with the classical contour-based registration. Our results have been shown to be superior to the classical ones.展开更多
Sonar images have complex background, low contrast, and deteriorative edges; these characteristics make it difficult for researchers to dispose the sonar objects. The multi-resolution analysis represents the signals i...Sonar images have complex background, low contrast, and deteriorative edges; these characteristics make it difficult for researchers to dispose the sonar objects. The multi-resolution analysis represents the signals in different scales efficiently, which is widely used in image processing. Wavelets are successful in disposing point discontinuities in one dimension, but not in two dimensions. The finite Ridgelet transform （FRIT） deals efficiently with the singularity in high dimension. It presents three improved denoising approaches, which are based on FRIT and used in the sonar image disposal technique. By experiment and comparison with traditional methods, these approaches not only suppress the artifacts, but also obtain good effect in edge keeping and SNR of the sonar image denoising.展开更多
Aiming at the higher bit-rate occupation of motion vector encoding and more time load of full-searching strategies, a multi-resolution motion estimation and compensation algorithm based on adjacent prediction of frame...Aiming at the higher bit-rate occupation of motion vector encoding and more time load of full-searching strategies, a multi-resolution motion estimation and compensation algorithm based on adjacent prediction of frame difference was proposed.Differential motion detection was employed to image sequences and proper threshold was adopted to identify the connected region.Then the motion region was extracted to carry out motion estimation and motion compensation on it.The experiment results show that the encoding efficiency of motion vector is promoted, the complexity of motion estimation is reduced and the quality of the reconstruction image at the same bit-rate as Multi-Resolution Motion Estimation(MRME) is improved.展开更多
The density field around a vortex generator （VG） in supersonic flow is studied with a nanoparticle-based planar laser scattering （NPLS） method. Based on the calibration, i.e., the density distribution of the super...The density field around a vortex generator （VG） in supersonic flow is studied with a nanoparticle-based planar laser scattering （NPLS） method. Based on the calibration, i.e., the density distribution of the supersonic flow around a wedge, the density field of a supersonic VG is measured. According to movement characteristics of coherent structure in VG’s flow fields and the basic concepts of wavelet, the density fluctuating signals and multi-resolution characteristics of density field images are studied. The multi-resolution characteristics of density fluctuation can be analyzed with wavelet transformation of NPLS images. The wavelet approximate coefficients of density fluctuating signals exhibit their characteristics at different scales, and the corresponding detail coefficients show the difference of diverse layer smooth approximation in some way. Based on 2D wavelet decomposition and reconstruction of density field images, the approximate and detail signals at different scales are studied, and the coherent structures at different scales are extracted and analyzed.展开更多
We propose a high-performance path planning algorithm for automatic target tracking in the applications of real-time simulation and visualization of large-scale terrain datasets, with a large number of moving objects ...We propose a high-performance path planning algorithm for automatic target tracking in the applications of real-time simulation and visualization of large-scale terrain datasets, with a large number of moving objects （such as vehicles） tracking multiple moving targets. By using a modified Dijkstra＇s algorithm, an optimal path between each vehicle-target pair over a weighted grid-presented terrain is computed and updated to eliminate the problem of local minima and losing of tracking. Then, a dynamic path re-planning strategy using multi-resolution representation of a dynamic updating region is proposed to achieve high-performance by trading-off precision for efficiency, while guaranteeing accuracy. Primary experimental results showed that our algorithm successfully achieved l0 to 96 frames per second interactive path-replanning rates during a terrain simulation scenario with 10 to 100 vehicles and multiple moving targets.展开更多
The acoustic vibration signal of tank is disassembled into the sum of intrinsic mode function （IMF） by multi-resolution empirical mode decomposition （EMD） method. The instantaneous frequency is obtained, and featu...The acoustic vibration signal of tank is disassembled into the sum of intrinsic mode function （IMF） by multi-resolution empirical mode decomposition （EMD） method. The instantaneous frequency is obtained, and feature transformation matrix is figured out by class scatter matrix. Multi- dimensional scale energy vector is mapped into low-dimensional eigenvector, and classification extraction is realized. This method sufficiently separates of different sound target features. The test result indicates that it is effective.展开更多
基金supported by the National Natural Science Foundation of China(62175034,62175036,32271510)the National Key R&D Program of China(2021YFF0502900)+2 种基金the Science and Technology Research Program of Shanghai(Grant No.19DZ2282100)the Shanghai Key Laboratory of Metasurfaces for Light Manipulation(23dz2260100)the Shanghai Engineering Technology Research Center of Hair Medicine(19DZ2250500).
文摘A new scheme of super-resolution optical fluctuation imaging(SOFI)is proposed to broaden its application in the high-order cumulant reconstruction by optimizing blinking characteristics,eliminating noise in raw data and applying multi-resolution analysis in cumulant reconstruction.A motor-driven rotating mask optical modulation system is designed to adjust the excitation lightfield and allows for fast deployment.Active-modulated fluorescence fluctuation superresolution microscopy with multi-resolution analysis(AMF-MRA-SOFI)demonstrates enhanced resolution ability and reconstruction quality in experiments performed on sample of conventional dyes,achieving a resolution of 100 nm in the fourth order compared to conventional SOFI reconstruction.Furthermore,our approach combining expansion super-resolution achieved a resolution at-57 nm.
基金partially funded by the National Natural Science Foundation of China(Grant No.52171329)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2024B1515020107)+1 种基金the Young Elite Scientist Sponsorship Program by CAST(Grant No.2022QNRC001)Characteristic Innovation Project of Universities in Guangdong Province(Grant No.2023KTSCX005).
文摘A multi-resolution smoothed particle hydrodynamics and peridynamics(SPH-PD)coupling model is proposed in this study for simulating the fracture characteristics of ice plates exposed to underwater blast loads.The SPH model employs a volume adaptive scheme(VAS)and a multi-resolution particle technique to accurately simulate explosive charge detonation and shock wave propagation.This approach addresses numerical challenges from charge expansion and significant size disparity between the charge and the fluid particles.The model captures the full underwater explosion process,covering both the shock wave phase and the bubble expansion stage,by applying appropriate equations of state for each respective phase.To analyze ice plate damage and crack propagation influenced by temperature changes,an ordinary state-based PD(OSB-PD)formulation with coupled mechanical and thermodynamic models is used.Numerical results show that the proposed coupling method demonstrates good agreement with reference solutions and experimental data.
文摘This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.
基金supported by the National Natural Science Foundation of China,82471345(to LC)the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
文摘Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.
文摘Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.
基金the support from Base for Interdisciplinary Innovative Talent Training,Shanghai Jiao Tong UniversityYouth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine。
文摘Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.
基金supported by the National Natural Science Foundation of China[82003956]the National Key Research and Development Program of China[No.2022YFA1205802]+2 种基金financially supported by Henan Province Health Science and Technology Innovation Youth Talent Project(YQRC2023013 and YQRC2024013)the Key Project of Medical Science and Technology of Henan Province(SBGJ202302072)the Science and Technology Research Project of Henan Province(252102311236).
文摘Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.
基金supported by the Natural Science Foundation of China(No.52470105)the Young Taishan Scholars Program of Shandong Province(No.358202103017).
文摘The discharge of micro-polluted water from sources such as agricultural runoff,urban stormwater,and treated effluents presents significant challenges to aquatic ecosystems.Constructed wetlands(CWs)have gained recog-nition as an eco-friendly solution for removing pollutants from various wastewater sources and are increasingly applied for micro-polluted water treatment.By reviewing 78 full-scale CW studies from Web of Science,it is summarized that the ranges of ammonium nitrogen(NH4+-N)concentrations in runoff,wastewater treatment plant effluent and polluted river were 0.1–6.6,0.3–12.3,and 0.2–41.1 mg/L,respectively.The ranges of ni-trate nitrogen concentrations were 0.2–14.2,0–5.7,and 0–2.6 mg/L,respectively.Removal efficiencies of CWs for micro-polluted water varied by CW types.The total nitrogen removal efficiencies for subsurface-flow CWs,free-water surface-flow CWs,and hybrid CWs ranged from 27.4%to 66.5%,16.8%to 89.8%,and 19.4%to 88.2%,respectively.The NH4+-N removal efficiencies ranged from 34.2%to 73.6%,38.4%to 89.4%and 13.5%to 94.2%,respectively.Additionally,other factors influencing contaminant removal efficiency such as hydraulic retention time,vegetation types,redox micro-environment and influent water quality were evaluated.Based on these findings,two strategies for improving the purification performance of CWs were proposed:the selection of incorporating electron donor substrates and the optimization of operation parameters.This paper serves as a synthesis of information to guide future research and full-scale CW applications in micro-polluted water treatment.
基金supports from the National Natural Science Foundation of China(Grant Nos.12305372 and 22376217)the National Key Research&Development Program of China(Grant Nos.2022YFA1603802 and 2022YFB3504100)+1 种基金the projects of the key laboratory of advanced energy materials chemistry,ministry of education(Nankai University)key laboratory of Jiangxi Province for persistent pollutants prevention control and resource reuse(2023SSY02061)are gratefully acknowledged.
文摘Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespread attention for CO_(2)RR due to their high catalytic activity,selectivity,excellent stability,and low cost.However,they still need to be further improved to meet the needs of industrial applications.This review article comprehensively summarizes the recent advances in regulation strategies of Bi-based catalysts and can be divided into six categories:(1)defect engineering,(2)atomic doping engineering,(3)organic framework engineering,(4)inorganic heterojunction engineering,(5)crystal face engineering,and(6)alloying and polarization engineering.Meanwhile,the corresponding catalytic mechanisms of each regulation strategy will also be discussed in detail,aiming to enable researchers to understand the structure-property relationship of the improved Bibased catalysts fundamentally.Finally,the challenges and future opportunities of the Bi-based catalysts in the photoelectrocatalytic CO_(2)RR application field will also be featured from the perspectives of the(1)combination or synergy of multiple regulatory strategies,(2)revealing formation mechanism and realizing controllable synthesis,and(3)in situ multiscale investigation of activation pathways and uncovering the catalytic mechanisms.On the one hand,through the comparative analysis and mechanism explanation of the six major regulatory strategies,a multidimensional knowledge framework of the structure-activity relationship of Bi-based catalysts can be constructed for researchers,which not only deepens the atomic-level understanding of catalytic active sites,charge transport paths,and the adsorption behavior of intermediate products,but also provides theoretical guiding principles for the controllable design of new catalysts;on the other hand,the promising collaborative regulation strategies,controllable synthetic paths,and the in situ multiscale characterization techniques presented in this work provides a paradigm reference for shortening the research and development cycle of high-performance catalysts,conducive to facilitating the transition of photoelectrocatalytic CO_(2)RR technology from the laboratory routes to industrial application.
基金supported by the National Science and Technology Major Project of China(No.2011ZX05029-003)CNPC Science Research and Technology Development Project,China(No.2013D-0904)
文摘In this study, we used the multi-resolution graph-based clustering （MRGC） method for determining the electrofacies （EF） and lithofacies （LF） from well log data obtained from the intraplatform bank gas fields located in the Amu Darya Basin. The MRGC could automatically determine the optimal number of clusters without prior knowledge about the structure or cluster numbers of the analyzed data set and allowed the users to control the level of detail actually needed to define the EF. Based on the LF identification and successful EF calibration using core data, an MRGC EF partition model including five clusters and a quantitative LF interpretation chart were constructed. The EF clusters 1 to 5 were interpreted as lagoon, anhydrite flat, interbank, low-energy bank, and high-energy bank, and the coincidence rate in the cored interval could reach 85%. We concluded that the MRGC could be accurately applied to predict the LF in non-cored but logged wells. Therefore, continuous EF clusters were partitioned and corresponding LF were characteristics ＆different LF were analyzed interpreted, and the distribution and petrophysical in the framework of sequence stratigraphy.
基金the financial support provided by the National Science & Technology Infrastructure Construction Project of China (2005DKA32300)the Key Science and Technology Project of Henan Province, China (152102110047)+2 种基金the Major Research Project of the Ministry of Education, China(16JJD770019)the Major Scientific and Technological Special Project of Henan Province, China (121100111300)the Cooperation Base Open Fund of the Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River regions and CPGIS (JOF 201602)
文摘Timely crop acreage and distribution information are the basic data which drive many agriculture related applications.For identifying crop types based on remote sensing,methods using only a single image type have significant limitations.Current research that integrates fine and coarser spatial resolution images,using techniques such as unmixing methods,regression models,and others,usually results in coarse resolution abundance without sufficient detail within pixels,and limited attention has been paid to the spatial relationship between the pixels from these two kinds of images.Here we propose a new solution to identify winter wheat by integrating spectral and temporal information derived from multi-resolution remote sensing data and determine the spatial distribution of sub-pixels within the coarse resolution pixels.Firstly,the membership of pixels which belong to winter wheat is calculated using a 25-m resolution resampled Landsat Thematic Mapper(TM)image based on the Bayesian equation.Then,the winter wheat abundance(acreage fraction in a pixel)is assessed by using a multiple regression model based on the unique temporal change features from moderate resolution imaging spectroradiometer(MODIS)time series data.Finally,winter wheat is identified by the proposed Abundance-Membership(AM)model based on the spatial relationship between the two types of pixels.Specifically,winter wheat is identified by comparing the spatially corresponding 10×10 membership pixels of each abundance pixel.In other words,this method takes advantage of the relative size of membership in a local space,rather than the absolute size in the entire study area.This method is tested in the major agricultural area of Yiluo Basin,China,and the results show that acreage accuracy(Aa)is 93.01%and sampling accuracy(As)is 91.40%.Confusion matrix shows that overall accuracy(OA)is 91.4%and the kappa coefficient(Kappa)is 0.755.These values are significantly improved compared to the traditional Maximum Likelihood classification(MLC)and Random Forest classification(RFC)which rely on spectral features.The results demonstrate that the identification accuracy can be improved by integrating spectral and temporal information.Since the identification of winter wheat is performed in the space corresponding to each MODIS pixel,the influence of differences of environmental conditions is greatly reduced.This advantage allows the proposed method to be effectively applied in other places.
基金This project was supported by the National Natural Foundation of China (60404022) and the Foundation of Department ofEducation of Hebei Province (2002209).
文摘Mixture model based image segmentation method, which assumes that image pixels are independent and do not consider the position relationship between pixels, is not robust to noise and usually leads to misclassification. A new segmentation method, called multi-resolution Ganssian mixture model method, is proposed. First, an image pyramid is constructed and son-father link relationship is built between each level of pyramid. Then the mixture model segmentation method is applied to the top level. The segmentation result on the top level is passed top-down to the bottom level according to the son-father link relationship between levels. The proposed method considers not only local but also global information of image, it overcomes the effect of noise and can obtain better segmentation result. Experimental result demonstrates its effectiveness.
基金supported by the National Natural Science Foundation of China(Grant Nos.11902085 and 11832009)the Science and Technology Association Young Scientific and Technological Talents Support Project of Guangzhou City(Grant No.SKX20210304)the Natural Science Foundation of Guangdong Province(Grant No.2021Al515010320).
文摘Huge calculation burden and difficulty in convergence are the two central conundrums of nonlinear topology optimization(NTO).To this end,a multi-resolution nonlinear topology optimization(MR-NTO)method is proposed based on the multiresolution design strategy(MRDS)and the additive hyperelasticity technique(AHT),taking into account the geometric nonlinearity and material nonlinearity.The MR-NTO strategy is established in the framework of the solid isotropic material with penalization(SIMP)method,while the Neo-Hookean hyperelastic material model characterizes the material nonlinearity.The coarse analysis grid is employed for finite element(FE)calculation,and the fine material grid is applied to describe the material configuration.To alleviate the convergence problem and reduce sensitivity calculation complexity,the software ANSYS coupled with AHT is utilized to perform the nonlinear FE calculation.A strategy for redistributing strain energy is proposed during the sensitivity analysis,i.e.,transforming the strain energy of the analysis element into that of the material element,including Neo-Hooken and second-order Yeoh material.Numerical examples highlight three distinct advantages of the proposed method,i.e.,it can(1)significantly improve the computational efficiency,(2)make up for the shortcoming that NTO based on AHT may have difficulty in convergence when solving the NTO problem,especially for 3D problems,(3)successfully cope with high-resolution 3D complex NTO problems on a personal computer.
基金Project supported by the National Natural Science Foundation of China (No. 60272031), the Hi-Tech Research and Development Program (863) of China (No. 2003AA131032-2), and the Natural Science Foundation of Zhejiang Province (No. M603202), China
文摘Multi-sensor image registration has been widely used in remote sensing and medical image field, but registration performance is degenerated when heterogeneous images are involved. An image registration method based on multi-resolution shape analysis is proposed in this paper, to deal with the problem that the shape of similar objects is always invariant. The contours of shapes are first detected as visual features using an extended contour search algorithm in order to reduce effects of noise, and the multi-resolution shape descriptor is constructed through Fourier curvature representation of the contour’s chain code. Then a minimum distance function is used to judge the similarity between two contours. To avoid the effect of different resolution and intensity distribution, suitable resolution of each image is selected by maximizing the consistency of its pyramid shapes. Finally, the transformation parameters are estimated based on the matched control-point pairs which are the centers of gravity of the closed contours. Multi-sensor Landsat TM imagery and infrared imagery have been used as experimental data for comparison with the classical contour-based registration. Our results have been shown to be superior to the classical ones.
基金This project was supported by the National Natural Science Foundation of China (60672034)the Research Fund for the Doctoral Program of Higher Education(20060217021)the Natural Science Foundation of Heilongjiang Province of China (ZJG0606-01)
文摘Sonar images have complex background, low contrast, and deteriorative edges; these characteristics make it difficult for researchers to dispose the sonar objects. The multi-resolution analysis represents the signals in different scales efficiently, which is widely used in image processing. Wavelets are successful in disposing point discontinuities in one dimension, but not in two dimensions. The finite Ridgelet transform （FRIT） deals efficiently with the singularity in high dimension. It presents three improved denoising approaches, which are based on FRIT and used in the sonar image disposal technique. By experiment and comparison with traditional methods, these approaches not only suppress the artifacts, but also obtain good effect in edge keeping and SNR of the sonar image denoising.
基金Supported by the National Natural Science Foundation of China (No. 60803036)the Scientific Research Fund of Heilongjiang Provincial Education Department (No.11531013)
文摘Aiming at the higher bit-rate occupation of motion vector encoding and more time load of full-searching strategies, a multi-resolution motion estimation and compensation algorithm based on adjacent prediction of frame difference was proposed.Differential motion detection was employed to image sequences and proper threshold was adopted to identify the connected region.Then the motion region was extracted to carry out motion estimation and motion compensation on it.The experiment results show that the encoding efficiency of motion vector is promoted, the complexity of motion estimation is reduced and the quality of the reconstruction image at the same bit-rate as Multi-Resolution Motion Estimation(MRME) is improved.
基金National Natural Science Foundation of China (11072264)
文摘The density field around a vortex generator （VG） in supersonic flow is studied with a nanoparticle-based planar laser scattering （NPLS） method. Based on the calibration, i.e., the density distribution of the supersonic flow around a wedge, the density field of a supersonic VG is measured. According to movement characteristics of coherent structure in VG’s flow fields and the basic concepts of wavelet, the density fluctuating signals and multi-resolution characteristics of density field images are studied. The multi-resolution characteristics of density fluctuation can be analyzed with wavelet transformation of NPLS images. The wavelet approximate coefficients of density fluctuating signals exhibit their characteristics at different scales, and the corresponding detail coefficients show the difference of diverse layer smooth approximation in some way. Based on 2D wavelet decomposition and reconstruction of density field images, the approximate and detail signals at different scales are studied, and the coherent structures at different scales are extracted and analyzed.
基金Project partially supported by NSF (No. CCR0306438) and theBoeing Company, USA
文摘We propose a high-performance path planning algorithm for automatic target tracking in the applications of real-time simulation and visualization of large-scale terrain datasets, with a large number of moving objects （such as vehicles） tracking multiple moving targets. By using a modified Dijkstra＇s algorithm, an optimal path between each vehicle-target pair over a weighted grid-presented terrain is computed and updated to eliminate the problem of local minima and losing of tracking. Then, a dynamic path re-planning strategy using multi-resolution representation of a dynamic updating region is proposed to achieve high-performance by trading-off precision for efficiency, while guaranteeing accuracy. Primary experimental results showed that our algorithm successfully achieved l0 to 96 frames per second interactive path-replanning rates during a terrain simulation scenario with 10 to 100 vehicles and multiple moving targets.
文摘The acoustic vibration signal of tank is disassembled into the sum of intrinsic mode function （IMF） by multi-resolution empirical mode decomposition （EMD） method. The instantaneous frequency is obtained, and feature transformation matrix is figured out by class scatter matrix. Multi- dimensional scale energy vector is mapped into low-dimensional eigenvector, and classification extraction is realized. This method sufficiently separates of different sound target features. The test result indicates that it is effective.
