A new scheme of super-resolution optical fluctuation imaging(SOFI)is proposed to broaden its application in the high-order cumulant reconstruction by optimizing blinking characteristics,eliminating noise in raw data a...A new scheme of super-resolution optical fluctuation imaging(SOFI)is proposed to broaden its application in the high-order cumulant reconstruction by optimizing blinking characteristics,eliminating noise in raw data and applying multi-resolution analysis in cumulant reconstruction.A motor-driven rotating mask optical modulation system is designed to adjust the excitation lightfield and allows for fast deployment.Active-modulated fluorescence fluctuation superresolution microscopy with multi-resolution analysis(AMF-MRA-SOFI)demonstrates enhanced resolution ability and reconstruction quality in experiments performed on sample of conventional dyes,achieving a resolution of 100 nm in the fourth order compared to conventional SOFI reconstruction.Furthermore,our approach combining expansion super-resolution achieved a resolution at-57 nm.展开更多
Sonar images have complex background, low contrast, and deteriorative edges; these characteristics make it difficult for researchers to dispose the sonar objects. The multi-resolution analysis represents the signals i...Sonar images have complex background, low contrast, and deteriorative edges; these characteristics make it difficult for researchers to dispose the sonar objects. The multi-resolution analysis represents the signals in different scales efficiently, which is widely used in image processing. Wavelets are successful in disposing point discontinuities in one dimension, but not in two dimensions. The finite Ridgelet transform （FRIT） deals efficiently with the singularity in high dimension. It presents three improved denoising approaches, which are based on FRIT and used in the sonar image disposal technique. By experiment and comparison with traditional methods, these approaches not only suppress the artifacts, but also obtain good effect in edge keeping and SNR of the sonar image denoising.展开更多
The density field around a vortex generator （VG） in supersonic flow is studied with a nanoparticle-based planar laser scattering （NPLS） method. Based on the calibration, i.e., the density distribution of the super...The density field around a vortex generator （VG） in supersonic flow is studied with a nanoparticle-based planar laser scattering （NPLS） method. Based on the calibration, i.e., the density distribution of the supersonic flow around a wedge, the density field of a supersonic VG is measured. According to movement characteristics of coherent structure in VG’s flow fields and the basic concepts of wavelet, the density fluctuating signals and multi-resolution characteristics of density field images are studied. The multi-resolution characteristics of density fluctuation can be analyzed with wavelet transformation of NPLS images. The wavelet approximate coefficients of density fluctuating signals exhibit their characteristics at different scales, and the corresponding detail coefficients show the difference of diverse layer smooth approximation in some way. Based on 2D wavelet decomposition and reconstruction of density field images, the approximate and detail signals at different scales are studied, and the coherent structures at different scales are extracted and analyzed.展开更多
A multi-resolution rectangular shell element with membrane-bending based on the Kirchhoff-Love theory is proposed. The multi-resolution analysis （MRA） framework is formulated out of a mutually nesting displacement s...A multi-resolution rectangular shell element with membrane-bending based on the Kirchhoff-Love theory is proposed. The multi-resolution analysis （MRA） framework is formulated out of a mutually nesting displacement subspace sequence, whose basis functions are constructed of scaling and shifting on the element domain of basic node shape functions. The basic node shape functions are constructed from shifting to other three quadrants around a specific node of a basic element in one quadrant and joining the corresponding node shape functions of four elements at the specific node. The MRA endows the proposed element with the resolution level （RL） to adjust the element node number, thus modulating structural analysis accuracy accordingly. The node shape functions of Kronecker delta property make the treatment of element boundary condition quite convenient and enable the stiffness matrix and the loading column vectors of the proposed element to be automatically acquired through quadraturing around nodes in RL adjusting. As a result, the traditional 4-node rectangular shell element is a mono-resolution one and also a special case of the proposed element. The accuracy of a structural analysis is actually determined by the RL, not by the mesh. The simplicity and clarity of node shape function formulation with the Kronecker delta property, and the rational MRA enable the proposed element method to be implemented more rationally, easily and efficiently than the conventional mono-resolution rectangular shell element method or other corresponding MRA methods.展开更多
Along with the massive applications of the non-linear loads and the impact loads, many non-stationary stochastic signals such as harmonics, inter-harmonics, impulse signals and so on are introduced into the electric n...Along with the massive applications of the non-linear loads and the impact loads, many non-stationary stochastic signals such as harmonics, inter-harmonics, impulse signals and so on are introduced into the electric network, and these non-stationary stochastic signals have had effects on the accuracy of the measurement of electric energy. The traditional method like Fourier Analysis can he applied efficiently on the stationary stochastic signals, hut it has little effect on non-stationary stochastic signals. In light of this, the form of the signals of the electric network in wavelet domain will he discussed in this paper. A measurement method of active power based on multi-resolution analysis in the stochastic process is presented. This method has a wider application scope compared with the traditional method Fourier analysis, and it is of good referential value and practical value in terms of raising the level of the existing electric energy measurement.展开更多
This paper expounded in detail the principle of energy spectrum analysis based on discrete wavelet transformation and multiresolution analysis. In the aspect of feature extraction method study, with investigating the ...This paper expounded in detail the principle of energy spectrum analysis based on discrete wavelet transformation and multiresolution analysis. In the aspect of feature extraction method study, with investigating the feature of impact factor in vibration signals and considering the non-placidity and non-linear of vibration diagnosis signals, the authors import wavelet analysis and fractal theory as the tools of faulty signal feature description. Experimental results proved the validity of this method. To some extent, this method provides a good approach of resolving the wholesome problem of fault feature symptom description.展开更多
In signal processing,multiresolution decomposition techniques allow for the separation of an acquired signal into sub levels,where the optimal level within the signal minimises redundancy,uncertainties,and contains th...In signal processing,multiresolution decomposition techniques allow for the separation of an acquired signal into sub levels,where the optimal level within the signal minimises redundancy,uncertainties,and contains the information required for the characterisation of the sensed phenomena.In the area of physiological signal processing for prosthesis control,scenarios where a signal decomposition analysis are required:the wavelet decomposition(WD)has been seen to be the favoured time-frequency approach for the decomposition of non-stationary signals.From a research perspective,the WD in certain cases has allowed for a more accurate motion intent decoding process following feature extraction and classification.Despite this,there is yet to be a widespread adaptation of the WD in a practical setting due to perceived computational complexity.Here,for neuro-muscular(electromyography)and brainwave(electroencephalography)signals acquired from a transhumeral amputee,a computationally efficient time domain signal decom-position method based on a series of heuristics was applied to process the acquired signals before feature extraction.The results showed an improvement in motion intent decoding prowess for the proposed time-domain-based signal decomposition across four different classifiers for both the neuromuscular and brain wave signals when compared to the WD and the raw signal.展开更多
A fidelity-ensured multi-resolution analysis deconvolution algorithm significantly enhances fluorescence microscopy's resolution and noise control,enabling more accurate and detailed imaging for advanced biologica...A fidelity-ensured multi-resolution analysis deconvolution algorithm significantly enhances fluorescence microscopy's resolution and noise control,enabling more accurate and detailed imaging for advanced biological research applications.展开更多
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'...Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.展开更多
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.展开更多
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A...The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.展开更多
AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current resea...AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current research international trends and hot topics in this area.METHODS:Bibliometric analysis was conducted on 9128 articles in the Web of Science Core Collection(WoSCC;Clarivate)database.Quantitative and qualitative analysis was employed using VOSviewer(v1.6.18),Pajek(v1.0.0.0),and CiteSpace(v6.1.R2)software.RESULTS:The 9128 papers relating to glaucoma treatment were published from April 2013 to April 2023,of which 7482 articles(82%)were original research articles and 1464(18%)were review articles.The United States(2867)and Johns Hopkins University(166)were the most productive country and institution,respectively,but the University College London had the highest h-index(54).The Journal of Glaucoma was the most productive and Ophthalmology had the highest h-index compared with other journals.The Keywords of interest included treatment surgery,cyclophotocoagulation,minimally invasive glaucoma surgery(MIGS),trabeculectomy,baerveldt,epidemiology,medication adherence,nanoparticle,optical coherence tomography(OCT),gene therapy,and artificial intelligence(AI).Glaucoma surgery appeared as a current research hotspot through the analysis of keywords.CONCLUSION:This study provides insights into the research trends and potential research hotspots in the treatment of glaucoma.This will help researchers to evaluate research policies and to promote international cooperation.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains i...To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains in a subcritical state during routine,normal,and accidental transport conditions.In the event of an accident,the rods within the storage tank may become rearranged,introducing uncertainty that must be accounted for to ensure that criticality analysis results are conservative.Historically,this uncertainty was addressed overly conservatively due to limited research on non-uniform arrangement scenarios,which proved unsuitable for criticality safety analysis of spent fuel packages.This paper introduced three distinct methods to non-uniformly rearrange fuel rods—Uniform Arrangement by Blocks,Layer-by-Layer Determination,and Birdcage Deformation—and meticulously evaluates the influences of rod rearrangement on the effective multiplication factor of neutrons,k eff,utilizing the Monte Carlo method.Ultimately,this study presents a holistic method capable of encompassing the entire spectrum of potential effects stemming from the rearrangement of fuel rods during rods mispositioning accident.By augmenting the safety margin,this approach proves to be adeptly suited for the criticality safety analysis of nuclear fuel transport containers.展开更多
Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may po...Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may pose certain environmental risks.Snow-melting agents and snow samples were collected and analyzed from highways,arterial roads,footbridges,and other locations in Beijing after the snowstorm in December 2023.It was found that the main component of snow-melting agents was sodium chloride with high concentrations of Cu,Mn,and Zn,which are not regulated in the current policies,despite the recent promotion of environmentally friendly snow-melting agents.The Pb,Zn and Cr contents of some snow samples exceeded the limitation value of surface water quality standards,potentially affecting the soil and water environment near roadsides,although the snow-melting agents comply with relevant standards,which indicates the policy gap in the management of recycled industrial salts.We reviewed and analyzed the relevant standards for snow-melting agents and industrial waste salts proposed nationally and internationally over the past 30 years.Through comparative analysis,we proposed relevant policy recommendations to the existing quality standards of snow-melting agents and the management regulations of industrial waste salts,and the formulation of corresponding usage strategies,aimed at reducing the potential environmental release of heavy metals from the use of snow-melting agents,thereby promoting more sustainable green urban development and environmentally sound waste management.展开更多
Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to i...Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice.展开更多
In this study, we used the multi-resolution graph-based clustering （MRGC） method for determining the electrofacies （EF） and lithofacies （LF） from well log data obtained from the intraplatform bank gas fields loc...In this study, we used the multi-resolution graph-based clustering （MRGC） method for determining the electrofacies （EF） and lithofacies （LF） from well log data obtained from the intraplatform bank gas fields located in the Amu Darya Basin. The MRGC could automatically determine the optimal number of clusters without prior knowledge about the structure or cluster numbers of the analyzed data set and allowed the users to control the level of detail actually needed to define the EF. Based on the LF identification and successful EF calibration using core data, an MRGC EF partition model including five clusters and a quantitative LF interpretation chart were constructed. The EF clusters 1 to 5 were interpreted as lagoon, anhydrite flat, interbank, low-energy bank, and high-energy bank, and the coincidence rate in the cored interval could reach 85%. We concluded that the MRGC could be accurately applied to predict the LF in non-cored but logged wells. Therefore, continuous EF clusters were partitioned and corresponding LF were characteristics ＆different LF were analyzed interpreted, and the distribution and petrophysical in the framework of sequence stratigraphy.展开更多
Multi-sensor image registration has been widely used in remote sensing and medical image field, but registration performance is degenerated when heterogeneous images are involved. An image registration method based on...Multi-sensor image registration has been widely used in remote sensing and medical image field, but registration performance is degenerated when heterogeneous images are involved. An image registration method based on multi-resolution shape analysis is proposed in this paper, to deal with the problem that the shape of similar objects is always invariant. The contours of shapes are first detected as visual features using an extended contour search algorithm in order to reduce effects of noise, and the multi-resolution shape descriptor is constructed through Fourier curvature representation of the contour’s chain code. Then a minimum distance function is used to judge the similarity between two contours. To avoid the effect of different resolution and intensity distribution, suitable resolution of each image is selected by maximizing the consistency of its pyramid shapes. Finally, the transformation parameters are estimated based on the matched control-point pairs which are the centers of gravity of the closed contours. Multi-sensor Landsat TM imagery and infrared imagery have been used as experimental data for comparison with the classical contour-based registration. Our results have been shown to be superior to the classical ones.展开更多
Logging facies analysis is a significant aspect of reservoir description.In particular,as a commonly used method for logging facies identification,Multi-Resolution Graph-based Clustering(MRGC)can perform depth analysi...Logging facies analysis is a significant aspect of reservoir description.In particular,as a commonly used method for logging facies identification,Multi-Resolution Graph-based Clustering(MRGC)can perform depth analysis on multidimensional logging curves to predict logging facies.However,this method is very time-consuming and highly dependent on the initial parameters in the propagation process,which limits the practical application effect of the method.In this paper,an Adaptive Multi-Resolution Graph-based Clustering(AMRGC)is proposed,which is capable of both improving the efficiency of calculation process and achieving a stable propagation result.More specifically,the proposed method,1)presents a light kernel representative index(LKRI)algorithm which is proved to need less calculation resource than those kernel selection methods in the literature by exclusively considering those"free attractor"points;2)builds a Multi-Layer Perceptron(MLP)network with back propagation algorithm(BP)so as to avoid the uncertain results brought by uncertain parameter initializations which often happened by only using the K nearest neighbors(KNN)method.Compared with those clustering methods often used in image-based sedimentary phase analysis,such as Self Organizing Map(SOM),Dynamic Clustering(DYN)and Ascendant Hierarchical Clustering(AHC),etc.,the AMRGC performs much better without the prior knowledge of data structure.Eventually,the experimental results illustrate that the proposed method also outperformed the original MRGC method on the task of clustering and propagation prediction,with a higher efficiency and stability.展开更多
基金supported by the National Natural Science Foundation of China(62175034,62175036,32271510)the National Key R&D Program of China(2021YFF0502900)+2 种基金the Science and Technology Research Program of Shanghai(Grant No.19DZ2282100)the Shanghai Key Laboratory of Metasurfaces for Light Manipulation(23dz2260100)the Shanghai Engineering Technology Research Center of Hair Medicine(19DZ2250500).
文摘A new scheme of super-resolution optical fluctuation imaging(SOFI)is proposed to broaden its application in the high-order cumulant reconstruction by optimizing blinking characteristics,eliminating noise in raw data and applying multi-resolution analysis in cumulant reconstruction.A motor-driven rotating mask optical modulation system is designed to adjust the excitation lightfield and allows for fast deployment.Active-modulated fluorescence fluctuation superresolution microscopy with multi-resolution analysis(AMF-MRA-SOFI)demonstrates enhanced resolution ability and reconstruction quality in experiments performed on sample of conventional dyes,achieving a resolution of 100 nm in the fourth order compared to conventional SOFI reconstruction.Furthermore,our approach combining expansion super-resolution achieved a resolution at-57 nm.
基金This project was supported by the National Natural Science Foundation of China (60672034)the Research Fund for the Doctoral Program of Higher Education(20060217021)the Natural Science Foundation of Heilongjiang Province of China (ZJG0606-01)
文摘Sonar images have complex background, low contrast, and deteriorative edges; these characteristics make it difficult for researchers to dispose the sonar objects. The multi-resolution analysis represents the signals in different scales efficiently, which is widely used in image processing. Wavelets are successful in disposing point discontinuities in one dimension, but not in two dimensions. The finite Ridgelet transform （FRIT） deals efficiently with the singularity in high dimension. It presents three improved denoising approaches, which are based on FRIT and used in the sonar image disposal technique. By experiment and comparison with traditional methods, these approaches not only suppress the artifacts, but also obtain good effect in edge keeping and SNR of the sonar image denoising.
基金National Natural Science Foundation of China (11072264)
文摘The density field around a vortex generator （VG） in supersonic flow is studied with a nanoparticle-based planar laser scattering （NPLS） method. Based on the calibration, i.e., the density distribution of the supersonic flow around a wedge, the density field of a supersonic VG is measured. According to movement characteristics of coherent structure in VG’s flow fields and the basic concepts of wavelet, the density fluctuating signals and multi-resolution characteristics of density field images are studied. The multi-resolution characteristics of density fluctuation can be analyzed with wavelet transformation of NPLS images. The wavelet approximate coefficients of density fluctuating signals exhibit their characteristics at different scales, and the corresponding detail coefficients show the difference of diverse layer smooth approximation in some way. Based on 2D wavelet decomposition and reconstruction of density field images, the approximate and detail signals at different scales are studied, and the coherent structures at different scales are extracted and analyzed.
基金financial support by the Open Foundation of Chongqing Key Laboratory of Geomechanics and Geoenvironment Protection(Logistical Engineering University)(No.GKLGGP 2013-02)
文摘A multi-resolution rectangular shell element with membrane-bending based on the Kirchhoff-Love theory is proposed. The multi-resolution analysis （MRA） framework is formulated out of a mutually nesting displacement subspace sequence, whose basis functions are constructed of scaling and shifting on the element domain of basic node shape functions. The basic node shape functions are constructed from shifting to other three quadrants around a specific node of a basic element in one quadrant and joining the corresponding node shape functions of four elements at the specific node. The MRA endows the proposed element with the resolution level （RL） to adjust the element node number, thus modulating structural analysis accuracy accordingly. The node shape functions of Kronecker delta property make the treatment of element boundary condition quite convenient and enable the stiffness matrix and the loading column vectors of the proposed element to be automatically acquired through quadraturing around nodes in RL adjusting. As a result, the traditional 4-node rectangular shell element is a mono-resolution one and also a special case of the proposed element. The accuracy of a structural analysis is actually determined by the RL, not by the mesh. The simplicity and clarity of node shape function formulation with the Kronecker delta property, and the rational MRA enable the proposed element method to be implemented more rationally, easily and efficiently than the conventional mono-resolution rectangular shell element method or other corresponding MRA methods.
文摘Along with the massive applications of the non-linear loads and the impact loads, many non-stationary stochastic signals such as harmonics, inter-harmonics, impulse signals and so on are introduced into the electric network, and these non-stationary stochastic signals have had effects on the accuracy of the measurement of electric energy. The traditional method like Fourier Analysis can he applied efficiently on the stationary stochastic signals, hut it has little effect on non-stationary stochastic signals. In light of this, the form of the signals of the electric network in wavelet domain will he discussed in this paper. A measurement method of active power based on multi-resolution analysis in the stochastic process is presented. This method has a wider application scope compared with the traditional method Fourier analysis, and it is of good referential value and practical value in terms of raising the level of the existing electric energy measurement.
文摘This paper expounded in detail the principle of energy spectrum analysis based on discrete wavelet transformation and multiresolution analysis. In the aspect of feature extraction method study, with investigating the feature of impact factor in vibration signals and considering the non-placidity and non-linear of vibration diagnosis signals, the authors import wavelet analysis and fractal theory as the tools of faulty signal feature description. Experimental results proved the validity of this method. To some extent, this method provides a good approach of resolving the wholesome problem of fault feature symptom description.
基金National Natural Science Foundation of China,Grant/Award Numbers:#U1613222,#81850410557,#8201101443The Shenzhen Science and Technology Program,Grant/Award Number:#SGLH20180625142402055CAS President's International Fellowship Initiative Grant,Grant/Award Number:#2019PB0036。
文摘In signal processing,multiresolution decomposition techniques allow for the separation of an acquired signal into sub levels,where the optimal level within the signal minimises redundancy,uncertainties,and contains the information required for the characterisation of the sensed phenomena.In the area of physiological signal processing for prosthesis control,scenarios where a signal decomposition analysis are required:the wavelet decomposition(WD)has been seen to be the favoured time-frequency approach for the decomposition of non-stationary signals.From a research perspective,the WD in certain cases has allowed for a more accurate motion intent decoding process following feature extraction and classification.Despite this,there is yet to be a widespread adaptation of the WD in a practical setting due to perceived computational complexity.Here,for neuro-muscular(electromyography)and brainwave(electroencephalography)signals acquired from a transhumeral amputee,a computationally efficient time domain signal decom-position method based on a series of heuristics was applied to process the acquired signals before feature extraction.The results showed an improvement in motion intent decoding prowess for the proposed time-domain-based signal decomposition across four different classifiers for both the neuromuscular and brain wave signals when compared to the WD and the raw signal.
基金supported by the Beijing Natural Science Foundation(1232027)the National Natural Science Foundation of China(62275010,U23A20481)the China Postdoctoral Science Foundation(2022M720347,2024T171115).
文摘A fidelity-ensured multi-resolution analysis deconvolution algorithm significantly enhances fluorescence microscopy's resolution and noise control,enabling more accurate and detailed imaging for advanced biological research applications.
文摘Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.
基金supported by Qingdao Key Medical and Health Discipline ProjectThe Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
文摘Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金financially supported by the National Natural Science Foundation of China(Nos.52034002 and U2202254)the Fundamental Research Funds for the Central Universities,China(No.FRF-TT-19-001)。
文摘The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.
基金Suppotred by Tianjin Key Medical Discipline Construction Project(No.TJYXZDXK-3-004A-2).
文摘AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current research international trends and hot topics in this area.METHODS:Bibliometric analysis was conducted on 9128 articles in the Web of Science Core Collection(WoSCC;Clarivate)database.Quantitative and qualitative analysis was employed using VOSviewer(v1.6.18),Pajek(v1.0.0.0),and CiteSpace(v6.1.R2)software.RESULTS:The 9128 papers relating to glaucoma treatment were published from April 2013 to April 2023,of which 7482 articles(82%)were original research articles and 1464(18%)were review articles.The United States(2867)and Johns Hopkins University(166)were the most productive country and institution,respectively,but the University College London had the highest h-index(54).The Journal of Glaucoma was the most productive and Ophthalmology had the highest h-index compared with other journals.The Keywords of interest included treatment surgery,cyclophotocoagulation,minimally invasive glaucoma surgery(MIGS),trabeculectomy,baerveldt,epidemiology,medication adherence,nanoparticle,optical coherence tomography(OCT),gene therapy,and artificial intelligence(AI).Glaucoma surgery appeared as a current research hotspot through the analysis of keywords.CONCLUSION:This study provides insights into the research trends and potential research hotspots in the treatment of glaucoma.This will help researchers to evaluate research policies and to promote international cooperation.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
文摘To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains in a subcritical state during routine,normal,and accidental transport conditions.In the event of an accident,the rods within the storage tank may become rearranged,introducing uncertainty that must be accounted for to ensure that criticality analysis results are conservative.Historically,this uncertainty was addressed overly conservatively due to limited research on non-uniform arrangement scenarios,which proved unsuitable for criticality safety analysis of spent fuel packages.This paper introduced three distinct methods to non-uniformly rearrange fuel rods—Uniform Arrangement by Blocks,Layer-by-Layer Determination,and Birdcage Deformation—and meticulously evaluates the influences of rod rearrangement on the effective multiplication factor of neutrons,k eff,utilizing the Monte Carlo method.Ultimately,this study presents a holistic method capable of encompassing the entire spectrum of potential effects stemming from the rearrangement of fuel rods during rods mispositioning accident.By augmenting the safety margin,this approach proves to be adeptly suited for the criticality safety analysis of nuclear fuel transport containers.
基金supported by the National Natural Science Foundation of China(No.22176200)the Industrial Innovation Entrepreneurial Team Project of Ordos 2021.
文摘Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may pose certain environmental risks.Snow-melting agents and snow samples were collected and analyzed from highways,arterial roads,footbridges,and other locations in Beijing after the snowstorm in December 2023.It was found that the main component of snow-melting agents was sodium chloride with high concentrations of Cu,Mn,and Zn,which are not regulated in the current policies,despite the recent promotion of environmentally friendly snow-melting agents.The Pb,Zn and Cr contents of some snow samples exceeded the limitation value of surface water quality standards,potentially affecting the soil and water environment near roadsides,although the snow-melting agents comply with relevant standards,which indicates the policy gap in the management of recycled industrial salts.We reviewed and analyzed the relevant standards for snow-melting agents and industrial waste salts proposed nationally and internationally over the past 30 years.Through comparative analysis,we proposed relevant policy recommendations to the existing quality standards of snow-melting agents and the management regulations of industrial waste salts,and the formulation of corresponding usage strategies,aimed at reducing the potential environmental release of heavy metals from the use of snow-melting agents,thereby promoting more sustainable green urban development and environmentally sound waste management.
文摘Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice.
基金supported by the National Science and Technology Major Project of China(No.2011ZX05029-003)CNPC Science Research and Technology Development Project,China(No.2013D-0904)
文摘In this study, we used the multi-resolution graph-based clustering （MRGC） method for determining the electrofacies （EF） and lithofacies （LF） from well log data obtained from the intraplatform bank gas fields located in the Amu Darya Basin. The MRGC could automatically determine the optimal number of clusters without prior knowledge about the structure or cluster numbers of the analyzed data set and allowed the users to control the level of detail actually needed to define the EF. Based on the LF identification and successful EF calibration using core data, an MRGC EF partition model including five clusters and a quantitative LF interpretation chart were constructed. The EF clusters 1 to 5 were interpreted as lagoon, anhydrite flat, interbank, low-energy bank, and high-energy bank, and the coincidence rate in the cored interval could reach 85%. We concluded that the MRGC could be accurately applied to predict the LF in non-cored but logged wells. Therefore, continuous EF clusters were partitioned and corresponding LF were characteristics ＆different LF were analyzed interpreted, and the distribution and petrophysical in the framework of sequence stratigraphy.
基金Project supported by the National Natural Science Foundation of China (No. 60272031), the Hi-Tech Research and Development Program (863) of China (No. 2003AA131032-2), and the Natural Science Foundation of Zhejiang Province (No. M603202), China
文摘Multi-sensor image registration has been widely used in remote sensing and medical image field, but registration performance is degenerated when heterogeneous images are involved. An image registration method based on multi-resolution shape analysis is proposed in this paper, to deal with the problem that the shape of similar objects is always invariant. The contours of shapes are first detected as visual features using an extended contour search algorithm in order to reduce effects of noise, and the multi-resolution shape descriptor is constructed through Fourier curvature representation of the contour’s chain code. Then a minimum distance function is used to judge the similarity between two contours. To avoid the effect of different resolution and intensity distribution, suitable resolution of each image is selected by maximizing the consistency of its pyramid shapes. Finally, the transformation parameters are estimated based on the matched control-point pairs which are the centers of gravity of the closed contours. Multi-sensor Landsat TM imagery and infrared imagery have been used as experimental data for comparison with the classical contour-based registration. Our results have been shown to be superior to the classical ones.
基金sponsored by the Science and Technology Project of CNPC(No.2018D-5010-16 and 2019D-3808)。
文摘Logging facies analysis is a significant aspect of reservoir description.In particular,as a commonly used method for logging facies identification,Multi-Resolution Graph-based Clustering(MRGC)can perform depth analysis on multidimensional logging curves to predict logging facies.However,this method is very time-consuming and highly dependent on the initial parameters in the propagation process,which limits the practical application effect of the method.In this paper,an Adaptive Multi-Resolution Graph-based Clustering(AMRGC)is proposed,which is capable of both improving the efficiency of calculation process and achieving a stable propagation result.More specifically,the proposed method,1)presents a light kernel representative index(LKRI)algorithm which is proved to need less calculation resource than those kernel selection methods in the literature by exclusively considering those"free attractor"points;2)builds a Multi-Layer Perceptron(MLP)network with back propagation algorithm(BP)so as to avoid the uncertain results brought by uncertain parameter initializations which often happened by only using the K nearest neighbors(KNN)method.Compared with those clustering methods often used in image-based sedimentary phase analysis,such as Self Organizing Map(SOM),Dynamic Clustering(DYN)and Ascendant Hierarchical Clustering(AHC),etc.,the AMRGC performs much better without the prior knowledge of data structure.Eventually,the experimental results illustrate that the proposed method also outperformed the original MRGC method on the task of clustering and propagation prediction,with a higher efficiency and stability.
