Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical eff...Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical effects and mechanisms in immune enhancement,adjunctive anti-tumor activity,and regulation of glucose/lipid metabolism.Three clinical trials were conducted.In an immune study,120 healthy volunteers(CD4+T cell count 500–1000 cells/μL)received 150 mg/day GFP-D for 8 weeks,resulting in significant increases in CD4+T cells(from 632±95 to 812±108 cells/μL,28.5%increase,within the physiological activation range),CD4+/CD8+ratio,NK cell activity,IL-2,and IFN-γ(all P<0.001 vs.placebo).An anti-tumor study with 80 advanced cancer patients(stratified by age,tumor stage,and histotype)showed that adding 1000 mg/day GFP-D to chemotherapy improved objective response rate(52.5%vs.30.0%,P=0.036,95%CI:1.02–3.87),one-year progression-free survival(55.8%vs.33.3%,P=0.022),and preserved immune parameters versus chemotherapy alone.A metabolic study in 90 type 2 diabetes patients found that 400 mg/day GFP-D for 12 weeks significantly lowered fasting glucose,HbA1c,total cholesterol,triglycerides,and LDL-C,while raising HDL-C(from 1.0±0.2 to 1.2±0.2 mmol/L,20%increase,supported by increased AMPK phosphorylation).Mechanistically,immune enhancement involves macrophage/dendritic cell activation via Dectin-1/TLR4 receptors(confirmed by increased receptor expression and downstream signaling molecules),promoting cytokine-driven T/NK cell responses.Anti-tumor effects stem from immunomodulation,direct induction of cancer cell apoptosis(via mitochondrial/caspase pathways,verified by increased Bax/Bcl-2 ratio and caspase-3 activation),and angiogenesis inhibition by downregulating VEGF.Metabolic benefits are linked to AMPK pathway activation in liver/muscle(confirmed by increased p-AMPK/AMPK ratio),enhancing glucose uptake and inhibiting gluconeogenesis/lipogenesis,alongside modulation of gut microbiota(increased Bifidobacterium and Lactobacillus abundance).All trials reported no severe adverse events related to GFP-D;liver/kidney function parameters(ALT,AST,creatinine,urea nitrogen)remained within normal ranges throughout the intervention.Collectively,GFP-D emerges as a multi-functional bioactive agent with substantial therapeutic potential.展开更多
A multi-modal action control approach is proposed for an autonomous soccer robot when the bottom hardware is unchangeable. Different from existing methods, the proposed control approach defines actions with the princi...A multi-modal action control approach is proposed for an autonomous soccer robot when the bottom hardware is unchangeable. Different from existing methods, the proposed control approach defines actions with the principle of ＂perception-planning-action＂ inspired by human intelligence. Character extraction is used to divide the perception input into different modes. Different control modes are built by combining different control methods for the linear velocity and angular velocity. Based on production rules, the motion control is realized by connecting different perceptions to the corresponding control mode. Simulation and real experiments are conducted with the middle-sized robot Frontier-I, and the proposed method is compared with a proportional-integral-derivative （PID） control method to display its feasibility and performance. The results show that the multi-modal action control method can make robots react rapidly in a dynamic environment.展开更多
Purpose: To test the concept of Statistical Process Control (SPC) as a Quality Assurance (QA) procedure for dose verifications in external beam radiation therapy in conventional and 3D Conformal Radiotherapy (3D-CRT) ...Purpose: To test the concept of Statistical Process Control (SPC) as a Quality Assurance (QA) procedure for dose verifications in external beam radiation therapy in conventional and 3D Conformal Radiotherapy (3D-CRT) treatment of cervical cancer. Materials and Methods: A study of QA verification of target doses of 198 cervical cancer patients undergoing External Beam Radiotherapy (EBRT) treatments at two different cancer treatment centers in Kenya was conducted. The target doses were determined from measured entrance doses by the diode in vivo dosimetry. Process Behavior Charts (PBC) developed by SPC were applied for setting Action Thresholds (AT) on the target doses. The AT set was then proposed as QA limits for acceptance or rejection of verified target doses overtime of the EBRT process. Result and Discussion: Target doses for the 198 patients were calculated and SPC applied to test whether the action limits set by the Process Behavior Charts could be applied as QA for verified doses in EBRT. Results for the two sub-groups of n = 3 and n = 4 that were tested produced action thresholds which are within clinical dose specifications for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. Conclusion: Action thresholds set by SPC were within the clinical dose specification of ±5% uncertainty for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. So the concept of SPC could be applied in setting QA action limits for dose verifications in EBRT.展开更多
This paper provides a solution to generalize the integrator and the integral control action. It is achieved by defining two function sets to generalize the integrator and the integral control action, respectively, res...This paper provides a solution to generalize the integrator and the integral control action. It is achieved by defining two function sets to generalize the integrator and the integral control action, respectively, resorting to a stabilizing controller and adopting Lyapunov method to analyze the stability of the closed-loop system. By originating a powerful Lyapunov function, a universal theorem to ensure regionally as well as semi-globally asymptotic stability is established by some bounded information. Consequently, the justification of two propositions on the generalization of integrator and integral control action is verified. Moreover, the conditions used to define the function sets can be viewed as a class of sufficient conditions to design the integrator and the integral control action, respectively.展开更多
Background:Exercise procrastination is prevalent among college students,causing decline in physical fitness.It is imperative to investigate the mechanism affecting college students’physical activity behaviors.This st...Background:Exercise procrastination is prevalent among college students,causing decline in physical fitness.It is imperative to investigate the mechanism affecting college students’physical activity behaviors.This study was aimed at investigating the effect of procrastination on college students’physical exercise behavior,and the chain mediation effects of exercise commitment and action control(AC),to provide a theoretical basis for interventions targeting physical exercise behavior among college students.Methods:A questionnaire survey was conducted using convenience sampling.The General Procrastination Scale,Exercise Commitment Scale,Action Control Scale,and Physical Activity Rating Scale-3 questionnaires were used.Participants were 581 college students(age 19.27±0.94 years;243 males and 338 females).Statistical methods of regression analysis and structural equation modeling(SEM)were applied.Results:Procrastination,exercise commitment,and action control were found to be significant predictors of physical exercise behavior.Among these predictors,exercise commitment and action control showed full mediation effects in the relationship between procrastination and physical exercise behavior,and explained 25.48%and 30.77%of the total variance,respectively.The chain mediation effect of exercise commitment-action control was significant,accounting for 22.60%of the total variance,and the total indirect effect was 79.33%.Conclusion:Therefore,higher procrastination was associated with less participation in physical exercise behavior among college students.Improvements in exercise commitment and volitional decision-making ability for physical exercise behavior promoted physical exercise behavior,and increased exercise commitment promoted volitional decision-making ability among the students.The chain reaction effect of exercise commitment and action control also buffered the negative effects of procrastination on physical exercise behavior,thereby increasing physical exercise behavior among college students.展开更多
Dear Editor,This letter deals with the stabilization problem of nonlinear stochastic systems via self-triggered impulsive control(STIC), where the timing of impulsive control actions is not dependent on continuous sta...Dear Editor,This letter deals with the stabilization problem of nonlinear stochastic systems via self-triggered impulsive control(STIC), where the timing of impulsive control actions is not dependent on continuous state monitoring. In contrast to the existing self-triggered control method, novel self-triggered mechanism(STM) is proposed by incorporating a waiting time for stabilizing impulses. This allows for direct prediction of the next impulsive instant.展开更多
Aiming at the problem that the distance between the main roadway and the working face in Hudi Coal Industry Panel was more than 100 m,which was still affected by mining,high stress concentration of the roadway,and dif...Aiming at the problem that the distance between the main roadway and the working face in Hudi Coal Industry Panel was more than 100 m,which was still affected by mining,high stress concentration of the roadway,and difficulty of supporting overall convergence of the section,the mechanical characteristics of the core bearing strata of the overlying rock caving in the working face were studied.The correlation mechanism between the overlying rock caving and the deformation and failure of the roadway was analyzed,and the quantitative evaluation index was established to comprehensively analyze different influencing factors.Based on the key strata theory,the mechanical difference transfer model of working face mining and panel roadway deformation and failure was established.It was considered that the difference in fracture morphology was the key to the far-field stress disturbance.The regional stress control technology was proposed to block or reduce the stress transfer,so that the peak stress of the panel main roadway was reduced,and the deformation of the surrounding rock was significantly reduced,which provides a reference value for the roadway support with serious influence of mining roadway.展开更多
This paper investigates an analytical optimal pose tracking control problem for chaser spacecraft during the close-range proximity operations with a non-cooperative space target subject to attitude tumbling and unknow...This paper investigates an analytical optimal pose tracking control problem for chaser spacecraft during the close-range proximity operations with a non-cooperative space target subject to attitude tumbling and unknown orbital maneuvering.Firstly,the relative translational motion between the orbital target and the chaser spacecraft is described in the Line-of-Sight(LOS)coordinate frame along with attitude quaternion dynamics.Then,based on the coupled 6-Degree of Freedom(DOF)pose dynamic model,an analytical optimal control action consisting of constrained optimal control value,application time and its duration are proposed via exploring the iterative sequential action control algorithm.Meanwhile,the global closed-loop asymptotic stability of the proposed predictive control action is presented and discussed.Compared with traditional proximity control schemes,the highlighting advantages are that the application time and duration of the devised controller is applied discretely in light of the influence of the instantaneous pose configuration on the pose tracking performance with less energy consumptions rather than at each sample time.Finally,three groups of illustrative examples are organized to validate the effectiveness of the proposed analytical optimal pose tracking control scheme.展开更多
In this paper,the optimal control of non-linear switching system is investigated without knowing the system dynamics.First,the Hamilton-Jacobi-Bellman(HJB)equation is derived with the consideration of hybrid action sp...In this paper,the optimal control of non-linear switching system is investigated without knowing the system dynamics.First,the Hamilton-Jacobi-Bellman(HJB)equation is derived with the consideration of hybrid action space.Then,a novel data-based hybrid Q-learning(HQL)algorithm is proposed to find the optimal solution in an iterative manner.In addition,the theoretical analysis is provided to illustrate the convergence and optimality of the proposed algorithm.Finally,the algorithm is implemented with the actor-critic(AC)structure,and two linear-in-parameter neural networks are utilized to approximate the functions.Simulation results validate the effectiveness of the data-driven method.展开更多
This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani,which examined the therapeutic potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)for metabolic dysfunction-associat...This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani,which examined the therapeutic potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)for metabolic dysfunction-associated fatty liver disease.We provide supplementary insights to their research,highlighting the broader systemic implications of GLP-1RAs,synthesizing the current understanding of their mechanisms and the trajectory of research in this field.GLP-1RAs are revolutionizing the treatment of type 2 diabetes mellitus and beyond.Beyond glycemic control,GLP-1RAs demonstrate cardiovascular and renal protective effects,offering potential in managing diabetic kidney disease alongside renin–angiotensin–aldosterone system inhibitors.Their role in bone metabolism hints at benefits for diabetic osteoporosis,while the neuroprotective properties of GLP-1RAs show promise in Alzheimer's disease treatment by modulating neuronal insulin signaling.Additionally,they improve hormonal and metabolic profiles in polycystic ovary syndrome.This editorial highlights the multifaceted mechanisms of GLP-1RAs,emphasizing the need for ongoing research to fully realize their therapeutic potential across a range of multisystemic diseases.展开更多
The technology of pressure relief gas drainage is one of the most effective and economic for preventing gas emissions in underground mines.Based on current understanding of strata breakage and fracture development in ...The technology of pressure relief gas drainage is one of the most effective and economic for preventing gas emissions in underground mines.Based on current understanding of strata breakage and fracture development in overlying strata,the current study divides the overlying strata into the following three longitudinal zones in terms of the state of gas flow:a turbulent channel zone,a transitional circulation channel zone and a seepage channel zone.According to the key strata discrimination theory of controlling the overlying strata,the calculation method establishes that the step-type expansion of the mining gas channel corresponds to the advancing distance of working face,and this research also confrms the expanding rule that the mining gas channel in overlying strata follows the advancing distance of mining working face.Based on the geological conditions of Xinjing Coal Mine of Yangquan,this paper researches the expanding rule of mining gas channel as well as the control action of the channel acting on the pressure relief flow under the condition of the remote protective layer,and got the distance using inversion that the step-type expanding of mining gas channel is corresponding to the advancing distance of working face,which verifes the accuracy and feasibility of theoretical calculation method proposed in this study.The research provides the theoretical basis for choosing the technology of pressure relief gas drainage and designing the parameters of construction.展开更多
Rhythmic phenomena are one of the most striking manifestations of dynamic behavior in biological systems. Understanding the mechanisms of biological rhythms, is crucial for understanding the dynamic of life. Each type...Rhythmic phenomena are one of the most striking manifestations of dynamic behavior in biological systems. Understanding the mechanisms of biological rhythms, is crucial for understanding the dynamic of life. Each type of dynamic behaviors may be related to the performance of both normal physiology and pathological. Conductive system of the heart can be stimulated to action as a network of elements and these elements show the oscillatory behavior then can be modeled as nonlinear oscillators. This paper provides the mathematical model of the heart rhythm by considering different states of Vanderpol nonlinear oscillators. Proposed oscillator model is designed in order to reproduce time series of action potential of natural pacemakers cardiac, such as SA or AV nodes. So model of heart is presented by a system of differential equations and to be considered chaotic or nonchaotic for different parameters of the model by using of the 0-1 test. Finally, the model is synchronized by applying an appropriate control signal, if it is needed.展开更多
This paper focuses on the problem of control law optimization for marine vessels working in a dynamical positioning （DP） regime. The approach proposed here is based on the use of a special unified multipurpose contr...This paper focuses on the problem of control law optimization for marine vessels working in a dynamical positioning （DP） regime. The approach proposed here is based on the use of a special unified multipurpose control law structure constructed on the basis of nonlinear asymptotic observers, that allows the decoupling of a synthesis into simpler particular optimization problems. The primary reason for the observers is to restore deficient information concerning the unmeasured velocities of the vessel. Using a number of separate items in addition to the observers, it is possible to achieve desirable dynamical features of the closed loop connection. The most important feature is the so-called dynamical corrector, and this paper is therefore devoted to solving its optimal synthesis in marine vessels controlled by DP systems under the action of sea wave disturbances. The problem involves the need for minimal intensity of the control action determined by high frequency sea wave components. A specialized approach for designing the dynamical corrector is proposed and the applicability and effectiveness of the approach are illustrated using a practical example of underwater DP system synthesis.展开更多
In this paper, an optimal control scheme for wind turbine output torque and power regulation under the influence of wind disturbances is presented. The system considered is a dynamic mechanical-based model with pitch ...In this paper, an optimal control scheme for wind turbine output torque and power regulation under the influence of wind disturbances is presented. The system considered is a dynamic mechanical-based model with pitch and generator torque actuators for controlling the pitch and generator torque. The performance of linear matrix inequality (LMI) formalism of linear quadratic regulator (LQR);linear quadratic regulator with integral action (LQRI) and model predictive control (MPC) were compared in response to a step change in wind disturbance. It is shown by Matlab simulation that the LQRI outperformed both LQR and MPC controllers.展开更多
文摘Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical effects and mechanisms in immune enhancement,adjunctive anti-tumor activity,and regulation of glucose/lipid metabolism.Three clinical trials were conducted.In an immune study,120 healthy volunteers(CD4+T cell count 500–1000 cells/μL)received 150 mg/day GFP-D for 8 weeks,resulting in significant increases in CD4+T cells(from 632±95 to 812±108 cells/μL,28.5%increase,within the physiological activation range),CD4+/CD8+ratio,NK cell activity,IL-2,and IFN-γ(all P<0.001 vs.placebo).An anti-tumor study with 80 advanced cancer patients(stratified by age,tumor stage,and histotype)showed that adding 1000 mg/day GFP-D to chemotherapy improved objective response rate(52.5%vs.30.0%,P=0.036,95%CI:1.02–3.87),one-year progression-free survival(55.8%vs.33.3%,P=0.022),and preserved immune parameters versus chemotherapy alone.A metabolic study in 90 type 2 diabetes patients found that 400 mg/day GFP-D for 12 weeks significantly lowered fasting glucose,HbA1c,total cholesterol,triglycerides,and LDL-C,while raising HDL-C(from 1.0±0.2 to 1.2±0.2 mmol/L,20%increase,supported by increased AMPK phosphorylation).Mechanistically,immune enhancement involves macrophage/dendritic cell activation via Dectin-1/TLR4 receptors(confirmed by increased receptor expression and downstream signaling molecules),promoting cytokine-driven T/NK cell responses.Anti-tumor effects stem from immunomodulation,direct induction of cancer cell apoptosis(via mitochondrial/caspase pathways,verified by increased Bax/Bcl-2 ratio and caspase-3 activation),and angiogenesis inhibition by downregulating VEGF.Metabolic benefits are linked to AMPK pathway activation in liver/muscle(confirmed by increased p-AMPK/AMPK ratio),enhancing glucose uptake and inhibiting gluconeogenesis/lipogenesis,alongside modulation of gut microbiota(increased Bifidobacterium and Lactobacillus abundance).All trials reported no severe adverse events related to GFP-D;liver/kidney function parameters(ALT,AST,creatinine,urea nitrogen)remained within normal ranges throughout the intervention.Collectively,GFP-D emerges as a multi-functional bioactive agent with substantial therapeutic potential.
基金supported by National Natural Science Foundation of China (No.60443004)Science and Technology Project of CQ Education Committee (No.KJ080621)
文摘A multi-modal action control approach is proposed for an autonomous soccer robot when the bottom hardware is unchangeable. Different from existing methods, the proposed control approach defines actions with the principle of ＂perception-planning-action＂ inspired by human intelligence. Character extraction is used to divide the perception input into different modes. Different control modes are built by combining different control methods for the linear velocity and angular velocity. Based on production rules, the motion control is realized by connecting different perceptions to the corresponding control mode. Simulation and real experiments are conducted with the middle-sized robot Frontier-I, and the proposed method is compared with a proportional-integral-derivative （PID） control method to display its feasibility and performance. The results show that the multi-modal action control method can make robots react rapidly in a dynamic environment.
文摘Purpose: To test the concept of Statistical Process Control (SPC) as a Quality Assurance (QA) procedure for dose verifications in external beam radiation therapy in conventional and 3D Conformal Radiotherapy (3D-CRT) treatment of cervical cancer. Materials and Methods: A study of QA verification of target doses of 198 cervical cancer patients undergoing External Beam Radiotherapy (EBRT) treatments at two different cancer treatment centers in Kenya was conducted. The target doses were determined from measured entrance doses by the diode in vivo dosimetry. Process Behavior Charts (PBC) developed by SPC were applied for setting Action Thresholds (AT) on the target doses. The AT set was then proposed as QA limits for acceptance or rejection of verified target doses overtime of the EBRT process. Result and Discussion: Target doses for the 198 patients were calculated and SPC applied to test whether the action limits set by the Process Behavior Charts could be applied as QA for verified doses in EBRT. Results for the two sub-groups of n = 3 and n = 4 that were tested produced action thresholds which are within clinical dose specifications for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. Conclusion: Action thresholds set by SPC were within the clinical dose specification of ±5% uncertainty for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. So the concept of SPC could be applied in setting QA action limits for dose verifications in EBRT.
文摘This paper provides a solution to generalize the integrator and the integral control action. It is achieved by defining two function sets to generalize the integrator and the integral control action, respectively, resorting to a stabilizing controller and adopting Lyapunov method to analyze the stability of the closed-loop system. By originating a powerful Lyapunov function, a universal theorem to ensure regionally as well as semi-globally asymptotic stability is established by some bounded information. Consequently, the justification of two propositions on the generalization of integrator and integral control action is verified. Moreover, the conditions used to define the function sets can be viewed as a class of sufficient conditions to design the integrator and the integral control action, respectively.
文摘Background:Exercise procrastination is prevalent among college students,causing decline in physical fitness.It is imperative to investigate the mechanism affecting college students’physical activity behaviors.This study was aimed at investigating the effect of procrastination on college students’physical exercise behavior,and the chain mediation effects of exercise commitment and action control(AC),to provide a theoretical basis for interventions targeting physical exercise behavior among college students.Methods:A questionnaire survey was conducted using convenience sampling.The General Procrastination Scale,Exercise Commitment Scale,Action Control Scale,and Physical Activity Rating Scale-3 questionnaires were used.Participants were 581 college students(age 19.27±0.94 years;243 males and 338 females).Statistical methods of regression analysis and structural equation modeling(SEM)were applied.Results:Procrastination,exercise commitment,and action control were found to be significant predictors of physical exercise behavior.Among these predictors,exercise commitment and action control showed full mediation effects in the relationship between procrastination and physical exercise behavior,and explained 25.48%and 30.77%of the total variance,respectively.The chain mediation effect of exercise commitment-action control was significant,accounting for 22.60%of the total variance,and the total indirect effect was 79.33%.Conclusion:Therefore,higher procrastination was associated with less participation in physical exercise behavior among college students.Improvements in exercise commitment and volitional decision-making ability for physical exercise behavior promoted physical exercise behavior,and increased exercise commitment promoted volitional decision-making ability among the students.The chain reaction effect of exercise commitment and action control also buffered the negative effects of procrastination on physical exercise behavior,thereby increasing physical exercise behavior among college students.
基金supported by the National Natural Science Foundation of China(62403393,12202058,62103118)the China Postdoctoral Science Foundation(2021T140160,2023 T160051)the Natural Science Foundation of Chongqing(CSTB 2023NSCQ-MSX0152)
文摘Dear Editor,This letter deals with the stabilization problem of nonlinear stochastic systems via self-triggered impulsive control(STIC), where the timing of impulsive control actions is not dependent on continuous state monitoring. In contrast to the existing self-triggered control method, novel self-triggered mechanism(STM) is proposed by incorporating a waiting time for stabilizing impulses. This allows for direct prediction of the next impulsive instant.
基金Project(2024B03017)supported by the Key Research and Development Program Projects of Xinjiang Uygur Autonomous Region,ChinaProjects(52225404,52394192)supported by the National Natural Science Foundation of China。
文摘Aiming at the problem that the distance between the main roadway and the working face in Hudi Coal Industry Panel was more than 100 m,which was still affected by mining,high stress concentration of the roadway,and difficulty of supporting overall convergence of the section,the mechanical characteristics of the core bearing strata of the overlying rock caving in the working face were studied.The correlation mechanism between the overlying rock caving and the deformation and failure of the roadway was analyzed,and the quantitative evaluation index was established to comprehensively analyze different influencing factors.Based on the key strata theory,the mechanical difference transfer model of working face mining and panel roadway deformation and failure was established.It was considered that the difference in fracture morphology was the key to the far-field stress disturbance.The regional stress control technology was proposed to block or reduce the stress transfer,so that the peak stress of the panel main roadway was reduced,and the deformation of the surrounding rock was significantly reduced,which provides a reference value for the roadway support with serious influence of mining roadway.
基金This study was co-supported by the National Natural Science Foundation of China(Nos.62003371,62373379,62103446,61273351,62073343)the Outstanding Youth Fund of Hunan Provincial Natural Science,China(No.2022JJ20081)the Innovation Driven Project of Central South University,China(No.2023CXQD066).
文摘This paper investigates an analytical optimal pose tracking control problem for chaser spacecraft during the close-range proximity operations with a non-cooperative space target subject to attitude tumbling and unknown orbital maneuvering.Firstly,the relative translational motion between the orbital target and the chaser spacecraft is described in the Line-of-Sight(LOS)coordinate frame along with attitude quaternion dynamics.Then,based on the coupled 6-Degree of Freedom(DOF)pose dynamic model,an analytical optimal control action consisting of constrained optimal control value,application time and its duration are proposed via exploring the iterative sequential action control algorithm.Meanwhile,the global closed-loop asymptotic stability of the proposed predictive control action is presented and discussed.Compared with traditional proximity control schemes,the highlighting advantages are that the application time and duration of the devised controller is applied discretely in light of the influence of the instantaneous pose configuration on the pose tracking performance with less energy consumptions rather than at each sample time.Finally,three groups of illustrative examples are organized to validate the effectiveness of the proposed analytical optimal pose tracking control scheme.
基金supported by the National Key R&D Program of China(2018AAA0101400)the Natural Science Foundation of Jiangsu Province of China(BK20202006)the National Natural Science Foundation of China(61921004,62173251).
文摘In this paper,the optimal control of non-linear switching system is investigated without knowing the system dynamics.First,the Hamilton-Jacobi-Bellman(HJB)equation is derived with the consideration of hybrid action space.Then,a novel data-based hybrid Q-learning(HQL)algorithm is proposed to find the optimal solution in an iterative manner.In addition,the theoretical analysis is provided to illustrate the convergence and optimality of the proposed algorithm.Finally,the algorithm is implemented with the actor-critic(AC)structure,and two linear-in-parameter neural networks are utilized to approximate the functions.Simulation results validate the effectiveness of the data-driven method.
基金Supported by National Natural Science Foundation of China,No.U23A20398 and No.82030007Sichuan Science and Technology Program,No.2022YFS0578.
文摘This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani,which examined the therapeutic potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)for metabolic dysfunction-associated fatty liver disease.We provide supplementary insights to their research,highlighting the broader systemic implications of GLP-1RAs,synthesizing the current understanding of their mechanisms and the trajectory of research in this field.GLP-1RAs are revolutionizing the treatment of type 2 diabetes mellitus and beyond.Beyond glycemic control,GLP-1RAs demonstrate cardiovascular and renal protective effects,offering potential in managing diabetic kidney disease alongside renin–angiotensin–aldosterone system inhibitors.Their role in bone metabolism hints at benefits for diabetic osteoporosis,while the neuroprotective properties of GLP-1RAs show promise in Alzheimer's disease treatment by modulating neuronal insulin signaling.Additionally,they improve hormonal and metabolic profiles in polycystic ovary syndrome.This editorial highlights the multifaceted mechanisms of GLP-1RAs,emphasizing the need for ongoing research to fully realize their therapeutic potential across a range of multisystemic diseases.
基金the National Basic Research Programs of China (No. 2011CB201204)the National Natural Science Foundation of China (Nos. 51074160)+1 种基金the Fundamental Research Funds for the Central Universities (No. 2010QNA03)Project Funded by the Priority Academic Program Development of Jiangsu Higher Education institutions for their support for this project
文摘The technology of pressure relief gas drainage is one of the most effective and economic for preventing gas emissions in underground mines.Based on current understanding of strata breakage and fracture development in overlying strata,the current study divides the overlying strata into the following three longitudinal zones in terms of the state of gas flow:a turbulent channel zone,a transitional circulation channel zone and a seepage channel zone.According to the key strata discrimination theory of controlling the overlying strata,the calculation method establishes that the step-type expansion of the mining gas channel corresponds to the advancing distance of working face,and this research also confrms the expanding rule that the mining gas channel in overlying strata follows the advancing distance of mining working face.Based on the geological conditions of Xinjing Coal Mine of Yangquan,this paper researches the expanding rule of mining gas channel as well as the control action of the channel acting on the pressure relief flow under the condition of the remote protective layer,and got the distance using inversion that the step-type expanding of mining gas channel is corresponding to the advancing distance of working face,which verifes the accuracy and feasibility of theoretical calculation method proposed in this study.The research provides the theoretical basis for choosing the technology of pressure relief gas drainage and designing the parameters of construction.
文摘Rhythmic phenomena are one of the most striking manifestations of dynamic behavior in biological systems. Understanding the mechanisms of biological rhythms, is crucial for understanding the dynamic of life. Each type of dynamic behaviors may be related to the performance of both normal physiology and pathological. Conductive system of the heart can be stimulated to action as a network of elements and these elements show the oscillatory behavior then can be modeled as nonlinear oscillators. This paper provides the mathematical model of the heart rhythm by considering different states of Vanderpol nonlinear oscillators. Proposed oscillator model is designed in order to reproduce time series of action potential of natural pacemakers cardiac, such as SA or AV nodes. So model of heart is presented by a system of differential equations and to be considered chaotic or nonchaotic for different parameters of the model by using of the 0-1 test. Finally, the model is synchronized by applying an appropriate control signal, if it is needed.
基金Partially Supported by the Russian Foundation for Basic Research(RFBR) under Research Project No.14-07-00083a
文摘This paper focuses on the problem of control law optimization for marine vessels working in a dynamical positioning （DP） regime. The approach proposed here is based on the use of a special unified multipurpose control law structure constructed on the basis of nonlinear asymptotic observers, that allows the decoupling of a synthesis into simpler particular optimization problems. The primary reason for the observers is to restore deficient information concerning the unmeasured velocities of the vessel. Using a number of separate items in addition to the observers, it is possible to achieve desirable dynamical features of the closed loop connection. The most important feature is the so-called dynamical corrector, and this paper is therefore devoted to solving its optimal synthesis in marine vessels controlled by DP systems under the action of sea wave disturbances. The problem involves the need for minimal intensity of the control action determined by high frequency sea wave components. A specialized approach for designing the dynamical corrector is proposed and the applicability and effectiveness of the approach are illustrated using a practical example of underwater DP system synthesis.
文摘In this paper, an optimal control scheme for wind turbine output torque and power regulation under the influence of wind disturbances is presented. The system considered is a dynamic mechanical-based model with pitch and generator torque actuators for controlling the pitch and generator torque. The performance of linear matrix inequality (LMI) formalism of linear quadratic regulator (LQR);linear quadratic regulator with integral action (LQRI) and model predictive control (MPC) were compared in response to a step change in wind disturbance. It is shown by Matlab simulation that the LQRI outperformed both LQR and MPC controllers.
