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A water probe for direct pH measurement of individual particles via micro-Raman spectroscopy
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作者 Xiaoyu Cui Mingjin Tang Tong Zhu 《Journal of Environmental Sciences》 2025年第3期200-208,共9页
The acidity of atmospheric aerosols influences fundamental physicochemical processes that affect climate and human health.We recently developed a novel and facilewater-probebased method for directly measuring of the p... The acidity of atmospheric aerosols influences fundamental physicochemical processes that affect climate and human health.We recently developed a novel and facilewater-probebased method for directly measuring of the pH for micrometer-size droplets,providing a promising technique to better understand aerosol acidity in the atmosphere.The complex chemical composition of fine particles in the ambient air,however,poses certain challenges to using a water-probe for pH measurement,including interference from interactions between compositions and the influence of similar compositions on water structure.To explore the universality of our method,it was employed to measure the pH of ammonium,nitrate,carbonate,sulfate,and chloride particles.The pH of particles covering a broad range(0–14)were accurately determined,thereby demonstrating that our method can be generally applied,even to alkaline particles.Furthermore,a standard spectral library was developed by integrating the standard spectra of common hydrated ions extracted through the waterprobe.The library can be employed to identify particle composition and overcome the spectral overlap problem resulting from similar effects.Using the spectral library,all ions were identified and their concentrations were determined,in turn allowing successful pH measurement of multicomponent(ammonium-sulfate-nitrate-chloride)particles.Insights into the synergistic effect of Cl^(–),NO_(3)^(–),and NH_(4)^(+)depletion obtained with our approach revealed the interplay between pH and volatile partitioning.Given the ubiquity of component partitioning and pH variation in particles,the water probemay provide a new perspective on the underlying mechanisms of aerosol aging and aerosol–cloud interaction. 展开更多
关键词 Particle pH Water probe Standard spectral library Micro-Raman spectroscopy direct measurement
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The influences of canopy temperature measuring on the derived crop water stress index 被引量:1
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作者 WANG Hongxi LI Fei +4 位作者 SHEN Hongtao LI Mengyu YIN Gongchao FANG Qin SHAO Liwei 《中国生态农业学报(中英文)》 CAS CSCD 北大核心 2024年第9期1503-1519,共17页
Crop water stress index(CWSI)is widely used for efficient irrigation management.Precise canopy temperature(T_(c))measurement is necessary to derive a reliable CWSI.The objective of this research was to investigate the... Crop water stress index(CWSI)is widely used for efficient irrigation management.Precise canopy temperature(T_(c))measurement is necessary to derive a reliable CWSI.The objective of this research was to investigate the influences of atmospheric conditions,settled height,view angle of infrared thermography,and investigating time of temperature measuring on the performance of the CWSI.Three irrigation treatments were used to create different soil water conditions during the 2020-2021 and 2021-2022 winter wheat-growing seasons.The CWSI was calculated using the CWSI-E(an empirical approach)and CWSI-T(a theoretical approach)based on the T_(c).Weather conditions were recorded continuously throughout the experimental period.The results showed that atmospheric conditions influenced the estimation of the CWSI;when the vapor pressure deficit(VPD)was>2000 Pa,the estimated CWSI was related to soil water conditions.The height of the installed infrared thermograph influenced the T_(c)values,and the differences among the T_(c)values measured at height of 3,5,and 10 m was smaller in the afternoon than in the morning.However,the lens of the thermometer facing south recorded a higher T_(c)than those facing east or north,especially at a low height,indicating that the direction of the thermometer had a significant influence on T_(c).There was a large variation in CWSI derived at different times of the day,and the midday measurements(12:00-15:00)were the most reliable for estimating CWSI.Negative linear relationships were found between the transpiration rate and CWSI-E(R^(2)of 0.3646-0.5725)and CWSI-T(R^(2)of 0.5407-0.7213).The relations between fraction of available soil water(FASW)with CWSI-T was higher than that with CWSI-E,indicating CWSI-T was more accurate for predicting crop water status.In addition,The R^(2)between CWSI-T and FASW at 14:00 was higher than that at other times,indicating that 14:00 was the optimal time for using the CWSI for crop water status monitoring.Relative higher yield of winter wheat was obtained with average seasonal values of CWSI-E and CWSI-T around 0.23 and 0.25-0.26,respectively.The CWSI-E values were more easily influenced by meteorological factors and the timing of the measurements,and using the theoretical approach to derive the CWSI was recommended for precise irrigation water management. 展开更多
关键词 Canopy temperature measuring time measuring height and direction Crop water stress index
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Study on Measurement Methods of Multi-Directional Waves—Wave Gauge Array Method 被引量:5
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作者 Yu Yuxiu Liu Shuxue Prof. Department of Civil Engineering, Dalian University of Technology, Dalian Assistant Researcher, Department of Civil Engineering, Dalian University of Technology, Dalian 《China Ocean Engineering》 SCIE EI 1992年第2期233-242,共10页
Measuring multi-directional waves with the wave gauge array is one of the fundamental and easily realised methods. In this paper, the wave gauge array is described and the effects of the gauge spacing, the array orien... Measuring multi-directional waves with the wave gauge array is one of the fundamental and easily realised methods. In this paper, the wave gauge array is described and the effects of the gauge spacing, the array orientations, etc. of the three array arrangements, i. e., linear array, T-type array and pentagon array, on the resolution of the directional spreading of waves, are investigated experimentally. This study can be used as a reference in the experimental study and the field measurement of directional waves. 展开更多
关键词 multi-directional waves measurement method directional spectrum wave gauge array
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The effect of different intensity measures and earthquake directions on the seismic assessment of skewed highway bridges 被引量:3
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作者 M.Bayat F.Daneshjoo N.Nistico 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2017年第1期165-179,共15页
In this study the probable seismic behavior of skewed bridges with continuous decks under earthquake excitations from different directions is investigated. A 45° skewed bridge is studied. A suite of 20 records is... In this study the probable seismic behavior of skewed bridges with continuous decks under earthquake excitations from different directions is investigated. A 45° skewed bridge is studied. A suite of 20 records is used to perform an Incremental Dynamic Analysis (IDA) for fragility curves. Four different earthquake directions have been considered: -45°, 0°, 22.5, 45°. A sensitivity analysis on different spectral intensity measures is presented; efficiency and practicality of different intensity measures have been studied. The fragility curves obtained indicate that the critical direction for skewed bridges is the skew direction as well as the longitudinal direction. The study shows the importance of finding the most critical earthquake in understanding and predicting the behavior of skewed bridges. 展开更多
关键词 skewed highway bridge earthquake direction spectral intensity measure analytical fragility curve
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Design of Measuring Instrument with Whole Direct Method for Bed Shear Stress Under Two-Dimensional Water-Flow Co-action
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作者 黄海龙 左其华 +2 位作者 周益人 沈雨生 李蓝汐 《China Ocean Engineering》 SCIE EI CSCD 2016年第6期916-925,共10页
The present study aims at the design and making of measuring instrument of whole direct method for bed shear stress under two-dimensional water-flow co-action. The instrument combines the traditional strain gauge with... The present study aims at the design and making of measuring instrument of whole direct method for bed shear stress under two-dimensional water-flow co-action. The instrument combines the traditional strain gauge with a precise pressure gauge, and adopts the method directly measuring the difference between the lateral hydrodynamic pressure and different head pressures on both sides of the force plate. As a result, such an instrument solves a technical puzzle of the past strain gauge, i.e. the difficulty to set apart shear stress and lateral force. Static force test and sink test both prove that the instrument is precise, stable and applicable to the measurement of rough beds with different shear stresses. 展开更多
关键词 direct method shear stress measurEMENT
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Investigation on the multi-hole directional coupler for power measurement of the J-TEXT ECRH system
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作者 Wenting WENG Donghui XIA +3 位作者 Yizhe TIAN Xixuan CHEN Zhijiang WANG Yuan PAN 《Plasma Science and Technology》 SCIE EI CAS CSCD 2022年第6期196-205,共10页
Power measurement is necessary for an electron cyclotron resonance heating(ECRH)system.The directional coupler method has been put forward to monitor high-power microwave from gyrotrons in real time.A multi-hole direc... Power measurement is necessary for an electron cyclotron resonance heating(ECRH)system.The directional coupler method has been put forward to monitor high-power microwave from gyrotrons in real time.A multi-hole directional coupler has been designed and manufactured for the 105 GHz/500 kW ECRH system on the J-TEXT tokamak.During the design process,we established the relationships between hole parameters and coupling characteristics based on the multi-hole coupling method and small-hole coupling theory.High-power tests have been carried out.The results indicated the reasonability of the theoretical design and practicality of the fabricated directional coupler.Sources of test errors have been discussed in detail,and the influences of spurious modes on the directional couplers have been emphatically analyzed. 展开更多
关键词 directional couplers power measurement ECRH system
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The Type of Low-yielding Fields,Using Direction and Land Fertility Building Measures in Suiping County
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作者 Jiuyi HU 《Asian Agricultural Research》 2014年第11期81-82,86,共3页
Using the evaluation indicator system for arable land fertility in Suiping County,this paper analyzes some factors influencing agricultural production,such as physical and chemical properties of soil,site conditions,s... Using the evaluation indicator system for arable land fertility in Suiping County,this paper analyzes some factors influencing agricultural production,such as physical and chemical properties of soil,site conditions,soil management,and soil nutrients concerning various types of low-yielding fields in the county. In accordance with the dominant soil constraint factors and main direction of improvement,the lowyielding fields in the county are divided into four types: irrigation improvement type,waterlogging drainage type,barren soil fertilization and barrier layer type. Finally this paper offers specific guidance on the construction of arable land. 展开更多
关键词 TYPE of low-yielding FIELDS USING direction LAND f
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Effects of Key Agricultural Measures of Mechanized Direct Seeding Technology on Rapeseed Yield in Chengdu Plain
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作者 姜心禄 代昌富 郑家国 《Agricultural Science & Technology》 CAS 2014年第9期1543-1549,共7页
Mechanized direct sowing of rapeseed is a labor-saving and highly-efficient culture technique. In order to explore high-yield cultivation techniques suitable for Chengdu Plain, effects of several key agronomic measure... Mechanized direct sowing of rapeseed is a labor-saving and highly-efficient culture technique. In order to explore high-yield cultivation techniques suitable for Chengdu Plain, effects of several key agronomic measures', such as sowing date, density and N fertilizers, on development and yield formation were studied by strip and split plot experiment of three factors. The research showed that optimal condi- tions for direct seeding technology can be achieved provided with scientific sowing date, density and appropriate N fertilizers, and the research showed that rapeseed yield reached the peak at 320 g/m2, when sowing date was on September 3th, sow- ing density was 30 plant/m2, and nitrogen fertilizer was 27 g/m2. 展开更多
关键词 RAPESEED Mechanized direct sowing Agricultural measures Yield characters: Effects
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Numerical study of AE and DRA methods in sandstone and granite in orthogonal loading directions 被引量:5
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作者 Xu-hua REN Hai-jun WANG Ji-xun ZHANG 《Water Science and Engineering》 EI CAS 2012年第1期93-104,共12页
The directional dependency of the acoustic emission (AE) and deformation rate analysis (DRA) methods was analyzed, based on the contact bond model in the two-dimensional particle flow code (PFC2D) in two types o... The directional dependency of the acoustic emission (AE) and deformation rate analysis (DRA) methods was analyzed, based on the contact bond model in the two-dimensional particle flow code (PFC2D) in two types of rocks, the coarse-grained sandstone and Aue granite. Each type of rocks had two shapes, the Brazilian disk and a square shape. The mechanical behaviors of the numerical model had already been verified to be in agreement with those of the physical specimens in previous research. Three loading protocols with different loading cycles in two orthogonal directions were specially designed in the numerical tests. The results show that no memory effect is observed in the second loading in the orthogonal direction. However, both the cumulative crack number of the second loading and the differential strain value at the inflection point are influenced by the first loading in the orthogonal direction. 展开更多
关键词 Kaiser effect deformation rate analysis PFC2D orthogonal loading directions in situ stress measurement
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Quantitative measurement of hydroxyl radical(OH) concentration in premixed flat flame by combining laser-induced fluorescence and direct absorption spectroscopy 被引量:3
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作者 陈爽 苏铁 +3 位作者 李中山 白菡尘 闫博 杨富荣 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第10期89-95,共7页
An accurate and reasonable technique combining direct absorption spectroscopy and laser-induced fluorescence(LIF)methods is developed to quantitatively measure the concentrations of hydroxyl in CH;/air flat laminar ... An accurate and reasonable technique combining direct absorption spectroscopy and laser-induced fluorescence(LIF)methods is developed to quantitatively measure the concentrations of hydroxyl in CH;/air flat laminar flame. In our approach, particular attention is paid to the linear laser-induced fluorescence and absorption processes, and experimental details as well. Through measuring the temperature, LIF signal distribution and integrated absorption, spatially absolute OH concentrations profiles are successfully resolved. These experimental results are then compared with the numerical simulation. It is proved that the good quality of the results implies that this method is suitable for calibrating the OH-PLIF measurement in a practical combustor. 展开更多
关键词 laser-induced fluorescence(LIF) direct absorption spectroscopy hydroxyl radical(OH) quantitative measurement
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Measurement-device-independent one-step quantum secure direct communication 被引量:4
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作者 Jia-Wei Ying Lan Zhou +1 位作者 Wei Zhong Yu-Bo Sheng 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第12期57-65,共9页
The one-step quantum secure direct communication(QSDC)(Sci.Bull.67,367(2022))can effectively simplify QSDC’s operation and reduce message loss.For enhancing its security under practical experimental condition,we prop... The one-step quantum secure direct communication(QSDC)(Sci.Bull.67,367(2022))can effectively simplify QSDC’s operation and reduce message loss.For enhancing its security under practical experimental condition,we propose two measurement-device-independent(MDI)one-step QSDC protocols,which can resist all possible attacks from imperfect measurement devices.In both protocols,the communication parties prepare identical polarization-spatial-mode two-photon hyperentangled states and construct the hyperentanglement channel by hyperentanglement swapping.The first MDI one-step QSDC protocol adopts the nonlinear-optical complete hyperentanglement Bell state measurement(HBSM)to construct the hyperentanglement channel,while the second protocol adopts the linear-optical partial HBSM.Then,the parties encode the photons in the polarization degree of freedom and send them to the third party for the hyperentanglementassisted complete polarization Bell state measurement.Both protocols are unconditionally secure in theory.The simulation results show the MDI one-step QSDC protocol with complete HBSM attains the maximal communication distance of about354 km.Our MDI one-step QSDC protocols may have potential applications in the future quantum secure communication field. 展开更多
关键词 measurement-device-independent one-step quantum secure direct communication hyperentanglement Bell state measurement hyperentanglement-assisted complete polarization Bell state measurement
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Method for Measuring Velocity of Warhead Fragments Based on Photoelectric Detection 被引量:8
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作者 倪晋平 杨雷 《Defence Technology(防务技术)》 SCIE EI CAS 2007年第4期275-280,共6页
For measuring velocity and impacting position of single fragment of warhead,a non-contact measuring method is proposed,in which a six-light-screen array,a position indicator,a multi-channel chronograph and a computer ... For measuring velocity and impacting position of single fragment of warhead,a non-contact measuring method is proposed,in which a six-light-screen array,a position indicator,a multi-channel chronograph and a computer are used.The principle of measurement is described.The key device of the system is a light screen array sensor which consists of six light screens allocated with certain geometrical parameters.When the fragment flies through the light screen array,the time of passing through each of the screens is recorded by the multi-channel chronograph.According to the time data and the geometrical parameters of the array,the velocity vector and the location of the fragment can be calculated immediately.The presented method can be used to locate the fragment and to measure the real velocity on its flying direction.It can also be used to measure the velocity of a fragment swarm after the system is engineered further. 展开更多
关键词 弹头 速度 方向 光电检测 轨迹
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Experimental Investigation of Wave Heights in A Directional Wave Field Through Image Sequences
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作者 Chung-Ren CHOU Teng-Wei LIN +1 位作者 Ruey-Syan SHIH John Z. YIMa 《China Ocean Engineering》 SCIE EI 2005年第1期37-48,共12页
Measurements of wave heights with image sequences from a Charged Coupled Device(CCD) camera were made. Sinusoidal, as well as unidirectional and directional, waves were used for the experiments. A transfer function wa... Measurements of wave heights with image sequences from a Charged Coupled Device(CCD) camera were made. Sinusoidal, as well as unidirectional and directional, waves were used for the experiments. A transfer function was obtained by calibration of the magnitudes of the gray values of the images against the results of wave gauge measurements for directional waves. With this transfer function, wave heights for regular waves were deduced. It is shown that the average relative errors are smaller than 16% for both unidirectional and directional waves. 展开更多
关键词 charged coupled device remote sensing directional wave transfer function wave height measurements
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Direct Measurements of the Electron Energy Flux versus Electron Temperature Gradient in Tokamak Discharges
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作者 K.W.Gentle M.E.Austin P.E.Phillips 《Plasma Science and Technology》 SCIE EI CAS CSCD 2004年第1期2130-2134,共5页
Electron thermal transport is one of the most complex processes in fusionplasmas. It is generally described by a simple thermal diffusivity in transport analyses ofdischarges, but there is evidence of critical gradien... Electron thermal transport is one of the most complex processes in fusionplasmas. It is generally described by a simple thermal diffusivity in transport analyses ofdischarges, but there is evidence of critical gradient effects with moderate stiffness. By analyzingperiodic perturbations to an equilibrium, one canmeasure the variations in electron energy flux andelectron temperature gradient over the perturbation cycle, obtaining the flux as a function ofgradient over the range of parameters generated by the perturbation. Although time-dependenttransport analysis is very sensitive to noise in the input data, averaging over many cycles of aperiodic perturbation can provide data of sufficient quality. The analyses presented here are basedon the ECE temperature data with high spatial and temporal resolution and full profile coverage onDIII-D for sawteeth and modulated ECH heating. 展开更多
关键词 tokamak discharges electron energy flux electron temperature gradient direct measurements
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Direct measurement of nonlocal quantum states without approximation
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作者 杨冈 杨然 +1 位作者 龚彦晓 祝世宁 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第11期252-256,共5页
Efficient acquiring information from a quantum state is important for research in fundamental quantum physics and quantum information applications. Instead of using standard quantum state tomography method with recons... Efficient acquiring information from a quantum state is important for research in fundamental quantum physics and quantum information applications. Instead of using standard quantum state tomography method with reconstruction algorithm, weak values were proposed to directly measure density matrix elements of quantum state. Recently, similar to the concept of weak value, modular values were introduced to extend the direct measurement scheme to nonlocal quantum wavefunction. However, this method still involves approximations, which leads to inherent low precision. Here, we propose a new scheme which enables direct measurement for ideal value of the nonlocal density matrix element without taking approximations. Our scheme allows more accurate characterization of nonlocal quantum states, and therefore has greater advantages in practical measurement scenarios. 展开更多
关键词 direct measurement quantum tomography nonlocal quantum state
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Direct measurement for general quantum states using parametric quantum circuits
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作者 Zhiyuan Wang Zijing Zhang Yuan Zhao 《Communications in Theoretical Physics》 SCIE CAS CSCD 2023年第1期39-45,共7页
In the field of quantum information,the acquisition of information for unknown quantum states is very important.When we only need to obtain specific elements of a state density matrix,the traditional quantum state tom... In the field of quantum information,the acquisition of information for unknown quantum states is very important.When we only need to obtain specific elements of a state density matrix,the traditional quantum state tomography will become very complicated,because it requires a global quantum state reconstruction.Direct measurement of the quantum state allows us to obtain arbitrary specific matrix elements of the quantum state without state reconstruction,so direct measurement schemes have obtained extensive attention.Recently,some direct measurement schemes based on weak values have been proposed,but extra auxiliary states in these schemes are necessary and it will increase the complexity of the practical experiment.Meanwhile,the post-selection process in the scheme will reduce the utilization of resources.In order to avoid these disadvantages,a direct measurement scheme without auxiliary states is proposed in this paper.In this scheme,we achieve the direct measurement of quantum states by using quantum circuits,then we extend it to the measurement of general multi-particle states and complete the error analysis.Finally,when we take into account the dephasing of the quantum states,we modify the circuits and the modified circuits still work for the dephasing case. 展开更多
关键词 direct quantum tomography quantum state measurement quantum circuits quantum gates
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Trajectory Control: Directional MWD Inversely New Wellbore Positioning Accuracy Prediction Method
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作者 Ahmed Abd Alaziz Ibrahim Tagwa Ahmed Musa 《Journal of China University of Geosciences》 SCIE CSCD 2004年第4期425-433,共9页
The deviation control of directional drilling is essentially the controlling of two angles of the wellbore actually drilled, namely, the inclination and azimuth. In directional drilling the bit trajectory never coinci... The deviation control of directional drilling is essentially the controlling of two angles of the wellbore actually drilled, namely, the inclination and azimuth. In directional drilling the bit trajectory never coincides exactly with the planned path, which is usually a plane curve with straight, building, holding, and dropping sections in succession. The drilling direction is of course dependant on the direction of the resultant forces acting on the bit and it is quite a tough job to hit the optimum target at the hole bottom as required. The traditional passive methods for correcting the drilling path have not met the demand to improve the techniques of deviation control. A method for combining wellbore surveys to obtain a composite, more accurate well position relies on accepting the position of the well from the most accurate survey instrument used in a given section of the wellbore. The error in each position measurement is the sum of many independent root sources of error effects. The relationship between surveys and other influential factors is considered, along with an analysis of different points of view. The collaborative work describes, establishes a common starting point of wellbore position uncertainty model, definition of what constitutes an error model, mathematics of position uncertainty calculation and an error model for basic directional service. 展开更多
关键词 wellbore trajectory bit trajectory actual/planned path steerable directional tool measurement while drilling (MWD) logging while drilling (LWD) position uncertainty error accuracy prediction weighting function
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Absolutely Direct Frequency Measurement of Two-Photon Transition Using Multi-Peak Fitting Approach
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作者 戴少阳 李坤乾 +5 位作者 翟跃阳 夏巍 王青 熊炜 齐向晖 陈徐宗 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第1期32-35,共4页
The optical frequency comb has been widely used in precision measurement. In this study, a multi-peak fitting approach is first proposed to fit the two-photon transition spectrum which overlaps with the neighboring tr... The optical frequency comb has been widely used in precision measurement. In this study, a multi-peak fitting approach is first proposed to fit the two-photon transition spectrum which overlaps with the neighboring transition in Rb-87. The multi-peak fitting approach is used to eliminate the frequency shift affected by the neighboring transition. With locking the carrier envelope offset frequency at 1/4 repetition frequency, the transition frequency is measured to be 770569132739.9 +/- 5.8 kHz, which agrees well with the previous result recommended by Comite International des Poids et Mesures. 展开更多
关键词 In Absolutely direct Frequency measurement of Two-Photon Transition Using Multi-Peak Fitting Approach Rb
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2-6 First Direct Measurement of 12C(12C, n)23Mg at Stellar Energies
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作者 Tang Xiaodong B. Bucher +28 位作者 X. Fang A. Heger S. Almaraz-Calderon A. Alongi A.D. Ayangeakaa M. Beard A. Best J. Browne C. Cahillane M. Couder R.J. deBoer A. Kontos L. Lamm Y.J. Li A. Long W. Lu S. Lyons M. Notani D. Patel N. Paul M. Pignatari A. Roberts D. Robertson K. Smith E. Stech R. Talwar W.P. Tan M. Wiescher S.E. Woosley 《IMP & HIRFL Annual Report》 2015年第1期56-58,共3页
The first stars in the early Universe were formed about 400 million years after the big bang. Verification of the existence of these stars is important for our understanding of the evolution of the Universe[1]. It has... The first stars in the early Universe were formed about 400 million years after the big bang. Verification of the existence of these stars is important for our understanding of the evolution of the Universe[1]. It has been predicted that for Population-III stellar production yields, the abundances of odd-Z elements are remarkably deficient compared to their adjacent even-Z elements[2]. Astronomers are searching for long-lived, low mass stars with the unique nucleosynthetic pattern matching the predicted yields[3]. 展开更多
关键词 FIRST direct measurEMENT
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Liver Stiffness Measurement Is Useful to Predict Early Recurrence of Hepatocellular Carcinoma after Sustained Virological Responses by Direct Antiviral Agents in Patients with Hepatitis C 被引量:1
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作者 Noboru Hirashima Hiroaki Iwase +3 位作者 Masaaki Shimada Noboru Urata Etsuko Iio Yasuhito Tanaka 《Open Journal of Gastroenterology》 2018年第7期255-268,共14页
Background: Recently, increases in the risk of Hepatocellular carcinoma (HCC) recurrence in patients with hepatitis C virus (HCV) due to the administration of direct antivirals agents (DAA) have been reported. Methods... Background: Recently, increases in the risk of Hepatocellular carcinoma (HCC) recurrence in patients with hepatitis C virus (HCV) due to the administration of direct antivirals agents (DAA) have been reported. Methods: One hundred and nineteen patients who were treated with DAA and achieved sustained viral response (SVR) were prospectively followed-up for over two years by transient elastography with liver stiffness measurements (LSM). Fourteen out of 119 patients (12%) had a history of being treated for HCC by radiofrequency ablation or resection and achieved complete responses after previous HCC treatments before the initiation of DAA. HCC was diagnosed by contrast-enhanced computed tomography (CT) or enhanced magnetic resonance imaging (MR). CT or MR was performed before the DAA treatment and every 6 months after during the follow-up. LSM was performed at the initiation of DAA (LSM0), at 24 weeks after the start of DAA (LSM24), at 48 weeks after that (LSM48) and at 2 years after that (LSM2y). Results: LSM0, LSM24, LSM48 and LSM2y of 105 patients without HCC were 7.5 (3.027.0), 6.0 (2.5 - 31.6), 4.6 (2.6?- 25.2) and 4.4 (3.1 - 29.9) kPa, respectively, showing significant improvements. Three out of 105 patients (2.9%) subsequently developed HCC and their LSM showed improvements. Eight out of fourteen patients (57%) with a history of HCC treatments subsequently developed HCC recurrence. LSM0 in the eight patients with recurrence increasing from 12.1 to 27.0 kPa, LSM24 from 9.9 to 26.6 kPa and LSM48 from 9.6 to 18.0 kPa. On the other hand, the six other patients without recurrence had LSM values that were less than 12.0 kPa at last. Based on the ROC analysis, LSM0 15.4, LSM24 12.8 and LSM48 9.6 kPa were identified as cut-off values. Conclusion: HCV patients previously treated for HCC with high LSM values before and after DAA have an elevated risk of HCC recurrence, particularly LSM24 >12.8 kPa and LSM48 >9.6 kPa. 展开更多
关键词 HEPATITIS C Virus Infection direct-Acting ANTIVIRALS HEPATOCELLULAR Carcinoma RECURRENCE Liver Stiffness measurement
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