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The potential mechanism and clinical application value of remote ischemic conditioning in stroke 被引量:3
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作者 Yajun Zhu Xiaoguo Li +6 位作者 Xingwei Lei Liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo 《Neural Regeneration Research》 SCIE CAS 2025年第6期1613-1627,共15页
Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may... Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved. 展开更多
关键词 Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke NEUROINFLAMMATION neuroprotection Notch1 PI3K remote ischemic conditioning STROKE
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Optimization method of conditioning factors selection and combination for landslide susceptibility prediction 被引量:1
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作者 Faming Huang Keji Liu +4 位作者 Shuihua Jiang Filippo Catani Weiping Liu Xuanmei Fan Jinsong Huang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第2期722-746,共25页
Landslide susceptibility prediction(LSP)is significantly affected by the uncertainty issue of landslide related conditioning factor selection.However,most of literature only performs comparative studies on a certain c... Landslide susceptibility prediction(LSP)is significantly affected by the uncertainty issue of landslide related conditioning factor selection.However,most of literature only performs comparative studies on a certain conditioning factor selection method rather than systematically study this uncertainty issue.Targeted,this study aims to systematically explore the influence rules of various commonly used conditioning factor selection methods on LSP,and on this basis to innovatively propose a principle with universal application for optimal selection of conditioning factors.An'yuan County in southern China is taken as example considering 431 landslides and 29 types of conditioning factors.Five commonly used factor selection methods,namely,the correlation analysis(CA),linear regression(LR),principal component analysis(PCA),rough set(RS)and artificial neural network(ANN),are applied to select the optimal factor combinations from the original 29 conditioning factors.The factor selection results are then used as inputs of four types of common machine learning models to construct 20 types of combined models,such as CA-multilayer perceptron,CA-random forest.Additionally,multifactor-based multilayer perceptron random forest models that selecting conditioning factors based on the proposed principle of“accurate data,rich types,clear significance,feasible operation and avoiding duplication”are constructed for comparisons.Finally,the LSP uncertainties are evaluated by the accuracy,susceptibility index distribution,etc.Results show that:(1)multifactor-based models have generally higher LSP performance and lower uncertainties than those of factors selection-based models;(2)Influence degree of different machine learning on LSP accuracy is greater than that of different factor selection methods.Conclusively,the above commonly used conditioning factor selection methods are not ideal for improving LSP performance and may complicate the LSP processes.In contrast,a satisfied combination of conditioning factors can be constructed according to the proposed principle. 展开更多
关键词 Landslide susceptibility prediction conditioning factors selection Support vector machine Random forest Rough set Artificial neural network
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Subsurface multi-physical monitoring of urban development zone using a fiber optic nerve system
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作者 Jing Wang Donghui Wang +3 位作者 Hong-Hu Zhu Ziqi Guo Dumin Yan Dao-Yuan Tan 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第7期4098-4108,共11页
The rapid expansion of urban development has led to the extensive construction of civil infrastructures.However,these urban development zones frequently face potential geohazards,primarily due to the lack of detailed ... The rapid expansion of urban development has led to the extensive construction of civil infrastructures.However,these urban development zones frequently face potential geohazards,primarily due to the lack of detailed site investigations and long-term monitoring of subsurface geological conditions.Understanding the temporal and spatial distributions of underground multi-field information is vital for successful engineering construction and effective utilization of urban underground space.In this study,a fiber optic nerve system(FONS)was utilized in the Tianfu New Area,Sichuan Province,China,to obtain comprehensive subsurface multi-physical information,including geological deformation,temperature,and surface hydrological data.The FONS incorporates three advanced fiber optic sensing techniques,i.e.fiber Bragg grating(FBG),Brillouin optical time domain reflectometry(BOTDR),and Raman optical time domain reflectometry(ROTDR).Fully-and quasi-distributed strain/temperature sensing cables have been installed in nine monitoring boreholes,covering various geological features such as plains,terraces,and areas within active fault zones.The field monitoring results confirm the feasibility of employing FONS for geological investigations within urban development zones,offering a valuable reference for future applications of this cost-effective technology in geohazard mitigation. 展开更多
关键词 Urban development zone Geotechnical monitoring multi-physical evolution Fiber optic sensor
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Exploration of the Application of Remote Ischemic Conditioning in Nursing of Cardiac Arrest
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作者 Yi-maizi Xu Mingyue Yang +3 位作者 Fangchi Liu Chao Zhang Yimeng Yan Zhixian Feng 《Journal of Clinical and Nursing Research》 2025年第4期121-129,共9页
Cardiac arrest(CA)is a major global public health challenge,and its high morbidity and low survival rate pose severe tests for emergency and critical care.Although modern CPR techniques significantly improve the immed... Cardiac arrest(CA)is a major global public health challenge,and its high morbidity and low survival rate pose severe tests for emergency and critical care.Although modern CPR techniques significantly improve the immediate resuscitation success rate in CA patients,poor outcomes such as neurological impairment still significantly increase the long-term care burden and reduce the quality of survival.In recent years,the application of remote ischemic conditioning(RIC)has attracted much attention in the field of cardiac arrest through its unique myocardial-nerve dual protection mechanism against the heart.This paper summarizes the conceptual connotation,physiological mechanism,operation method,and its application progress in CA and explores the potential of this technology in the field of CA care in order to provide reference for the research and application of RIC in the field of emergency care. 展开更多
关键词 Remote ischemic conditioning Cardiac arrest NURSING Review
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Development of a Liquid Desiccant Air Conditioning System Using Ionic Liquids
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作者 Hiroshi Nakayama Masatoshi Harada Xinming Wang 《Journal of Civil Engineering and Architecture》 2025年第2期74-81,共8页
LDACs(liquid desiccant air-conditioners)with heat pump can perform cooling dehumidification or heating humidification,and have high energy-saving and sterilization performance.Therefore,they are installed in hospitals... LDACs(liquid desiccant air-conditioners)with heat pump can perform cooling dehumidification or heating humidification,and have high energy-saving and sterilization performance.Therefore,they are installed in hospitals,nursing homes,and food factories,where humidity control is required.However,LiCl(lithium chloride),a conventional humidity control liquid,is highly corrosive to metals,requiring the use of highly corrosion-resistant materials for the pipes and the heat exchangers.These lead to the problem that the manufacturing cost of the air conditioner increases.Therefore,we developed an inexpensive and compact LDAC by adopting a novel IL(ionic liquid)that does not corrode the metals commonly used in air conditioners.In this study,we evaluated the metal solubilities and sterilizing properties of the IL.Based on the physical properties of the IL,the humidity control module was improved for the purpose of downsizing and cost reduction of the unit.Moreover,we conducted a performance evaluation of the LDAC in the environmental test room under the condition in which temperature and humidity change rapidly in short period of time to simulate the condition of sudden showers of rain in summer.Test results showed that processed air was supplied at very stable level. 展开更多
关键词 Liquid desiccant air conditioning ILS heat pump DEHUMIDIFICATION
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Improving the Performance of Thermoelectric Systems for Air Conditioning Using Different Configurations
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作者 Hind Abdulrahman Mahmood Ameer Abed Jaddoa Mohammed K.Al-Saadi 《Frontiers in Heat and Mass Transfer》 2025年第4期1281-1302,共22页
Thermoelectric air conditioning systems based on the Peltier effect had two modes:heating and cooling.In this work,the proposed design provides continuous improvement in COP from the first minute of operation.In cooli... Thermoelectric air conditioning systems based on the Peltier effect had two modes:heating and cooling.In this work,the proposed design provides continuous improvement in COP from the first minute of operation.In cooling mode,the coefficient of performance(COP)was 1.176 due to the techniques used in this device,and it increased to 1.24 in the last minute of operation.Concerning the steady-state scenario,from the first minute,the Qc was larger than the W for the entire duration of the operation.The output temperature reaches 18.97℃ ,and the temperature on the cold side reaches 4.96℃ in the fifteen minutes of operation.The cooling mood was checked in Iraq/Baghdad in October with a temperature of 31℃ .Furthermore,the heating mode was checked in December with a temperature of 22℃ .Due to the size of the component on the cold side being small compared with the size of the component on the heat side,it reached a steady state in 13 min.This means the COP in heating mode reached 1.01 in 14 min.Furthermore,due to the presence of a thermal insulator made inside the device to separate the cold side and the hot side,the difference in temperature causes a noticeable little ascent.This is why the COP increased because it kept the degree differences low.Performance enhancements were achieved by optimizing the behavior of thermoelectric materials.The device contains 3 Peltier elements,a water-cooled system with one Peltier,a heat sink,and a fan.The design of the dehumidification system addresses the humidity issue commonly associated with thermoelectric air conditioners.In this context,the results indicate that the humidity rates had decreased and the cooling rate had increased with these innovative techniques,and thus,excellent performance can be achieved even if the Seebeck coefficient is not at its highest based on the condition of providing the Peltier elements’reliability and optimal thermal performance for various applications requiring both cooling and heating functions.The insulation plays a critical role in maintaining the efficiency of the system,reducing energy consumption,and ensuring long-term functionality.The proposed system is valuable for devices or environments that demand precise and dual thermal control with minimal energy wastage. 展开更多
关键词 Peltier effect Seebeck coefficient COP THERMOELECTRIC air conditioning performance enhancement
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Study on the Impact of Humidity Control Strategy on Energy Saving Effect of Centralized Central Air Conditioning System
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作者 Xiaolian Lin 《Journal of Electronic Research and Application》 2025年第4期303-309,共7页
As an indispensable part of modern buildings,centralized central air conditioning systems play an important role in maintaining the comfort and air quality of the indoor environment.However,with the increasing energy ... As an indispensable part of modern buildings,centralized central air conditioning systems play an important role in maintaining the comfort and air quality of the indoor environment.However,with the increasing energy consumption,how to improve the energy efficiency ratio of air conditioning systems and reduce energy consumption has become an important issue in research and practice.The purpose of this paper is to discuss the impact of humidity control strategies on energy saving in centralized central air conditioning systems,with a view to providing a theoretical basis and practical guidance for realizing building energy efficiency. 展开更多
关键词 Centralized central air conditioning system Energy saving potential Humidity control strategy Energy saving effect assessment
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Research on the Path of Integrating Innovation and Entrepreneurship Education into the Curriculum Ideology and Politics of Refrigeration and Air Conditioning Major in Colleges and Universities
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作者 Tianjiao Zhang Xi Chen +1 位作者 Ni Liu Zhaorui Zhao 《Journal of Contemporary Educational Research》 2025年第9期398-404,共7页
In the background of reform of higher education in the new era,how to organically integrate innovation and entrepreneurship education with curriculum ideology and politics has become a key proposition for deepening th... In the background of reform of higher education in the new era,how to organically integrate innovation and entrepreneurship education with curriculum ideology and politics has become a key proposition for deepening the reform of education and teaching.As an important branch in the field of engineering,the refrigeration and air conditioning major not only undertakes the professional mission of cultivating technical talents in the industry,but also shoulders the era responsibility of implementing the fundamental task of cultivating morality and talents.Combining with the characteristics of the refrigeration and air conditioning major,this paper systematically analyzes the internal logic and practical significance of the integration of innovation and entrepreneurship education and curriculum ideology and politics,and explores its implementation paths in aspects such as the excavation of curriculum content,the innovation of teaching methods,the construction of practical platforms and the optimization of evaluation systems.It aims to provide practical reference and theoretical support for promoting the collaborative education of professional education and ideological and political education. 展开更多
关键词 Innovation and entrepreneurship education Curriculum ideology and politics Refrigeration and air conditioning Education reform
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An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation 被引量:2
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作者 Benfeng Gu Haiyuan Li Baoming Li 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期254-261,共8页
To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore damage.In this paper,a three-dime... To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore damage.In this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried out.Various test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of rail.Combining the simulation results and experimental data,the damage condition of the contact surface is analyzed. 展开更多
关键词 Internal ballistic modeling Electromagnetic rail gun multi-physics field coupling Experimental validation PFN
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Subsurface multi-physical characterization of mountain excavation and city construction in loess plateau with a fiber-optic sensing system 被引量:2
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作者 Jie Liu Bin Shi +3 位作者 Kai Gu Meng-Ya Sun Jun-Cheng Yao He-Ming Han 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第8期2935-2946,共12页
Mountain excavation and city construction(MECC)projects being launched in the Loess Plateau in China involve the creation of large-scale artificial land.Understanding the subsurface evolution characteristics of the ar... Mountain excavation and city construction(MECC)projects being launched in the Loess Plateau in China involve the creation of large-scale artificial land.Understanding the subsurface evolution characteristics of the artificial land is essential,yet challenging.Here,we use an improved fiber-optic monitoring system for its subsurface multi-physical characterization.The system enables us to gather spatiotemporal distribution of various parameters,including strata deformation,temperature,and moisture.Yan’an New District was selected as a case study to conduct refined in-situ monitoring through a 77 m-deep borehole and a 30 m-long trench.Findings reveal that the ground settlement involves both the deformation of the filling loess and the underlying intact loess.Notably,the filling loess exhibits a stronger creep capability compared to underlying intact loess.The deformation along the profile is unevenly distributed,with a positive correlation with soil moisture.Water accumulation has been observed at the interface between the filling loess and the underlying intact loess,leading to a significant deformation.Moreover,the temperature and moisture in the filling loess have reached a new equilibrium state,with their depths influenced by atmospheric conditions measuring at 31 m and 26 m,respectively.The refined investigation allows us to identify critical layers that matter the sustainable development of newly created urban areas,and provide improved insights into the evolution mechanisms of land creation. 展开更多
关键词 Mountain excavation and city construction Fiber-optic monitoring multi-physical characterization Compacted loess
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Simultaneously realizing thermal and electromagnetic cloaking by multi-physical null medium 被引量:1
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作者 Yichao Liu Xiaomin Ma +6 位作者 Kun Chao Fei Sun Zihao Chen Jinyuan Shan Hanchuan Chen Gang Zhao Shaojie Chen 《Opto-Electronic Science》 2024年第2期45-59,共15页
Simultaneously manipulating multiple physical fields plays an important role in the increasingly complex integrated systems,aerospace equipment,biochemical productions,etc.For on-chip systems with high integration lev... Simultaneously manipulating multiple physical fields plays an important role in the increasingly complex integrated systems,aerospace equipment,biochemical productions,etc.For on-chip systems with high integration level,the precise and efficient control of the propagation of electromagnetic waves and heat fluxes simultaneously is particularly important.In this study,we propose a graphical designing method(i.e.,thermal-electromagnetic surface transformation)based on thermal-electromagnetic null medium to simultaneously control the propagation of electromagnetic waves and thermal fields according to the pre-designed paths.A thermal-electromagnetic cloak,which can create a cloaking effect on both electromagnetic waves and thermal fields simultaneously,is designed by thermal-electromagnetic surface transformation and verified by both numerical simulations and experimental measurements.The thermal-electromagnetic surface transformation proposed in this study provides a new methodology for simultaneous controlling on electromagnetic and temperature fields,and may have significant applications in improving thermal-electromagnetic compatibility problem,protecting of thermal-electromagnetic sensitive components,and improving efficiency of energy usage for complex onchip systems. 展开更多
关键词 transformation optics multi-physical cloak null medium
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Uncertainties of landslide susceptibility prediction: Influences of random errors in landslide conditioning factors and errors reduction by low pass filter method 被引量:3
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作者 Faming Huang Zuokui Teng +4 位作者 Chi Yao Shui-Hua Jiang Filippo Catani Wei Chen Jinsong Huang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期213-230,共18页
In the existing landslide susceptibility prediction(LSP)models,the influences of random errors in landslide conditioning factors on LSP are not considered,instead the original conditioning factors are directly taken a... In the existing landslide susceptibility prediction(LSP)models,the influences of random errors in landslide conditioning factors on LSP are not considered,instead the original conditioning factors are directly taken as the model inputs,which brings uncertainties to LSP results.This study aims to reveal the influence rules of the different proportional random errors in conditioning factors on the LSP un-certainties,and further explore a method which can effectively reduce the random errors in conditioning factors.The original conditioning factors are firstly used to construct original factors-based LSP models,and then different random errors of 5%,10%,15% and 20%are added to these original factors for con-structing relevant errors-based LSP models.Secondly,low-pass filter-based LSP models are constructed by eliminating the random errors using low-pass filter method.Thirdly,the Ruijin County of China with 370 landslides and 16 conditioning factors are used as study case.Three typical machine learning models,i.e.multilayer perceptron(MLP),support vector machine(SVM)and random forest(RF),are selected as LSP models.Finally,the LSP uncertainties are discussed and results show that:(1)The low-pass filter can effectively reduce the random errors in conditioning factors to decrease the LSP uncertainties.(2)With the proportions of random errors increasing from 5%to 20%,the LSP uncertainty increases continuously.(3)The original factors-based models are feasible for LSP in the absence of more accurate conditioning factors.(4)The influence degrees of two uncertainty issues,machine learning models and different proportions of random errors,on the LSP modeling are large and basically the same.(5)The Shapley values effectively explain the internal mechanism of machine learning model predicting landslide sus-ceptibility.In conclusion,greater proportion of random errors in conditioning factors results in higher LSP uncertainty,and low-pass filter can effectively reduce these random errors. 展开更多
关键词 Landslide susceptibility prediction conditioning factor errors Low-pass filter method Machine learning models Interpretability analysis
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In-situ sludge reduction based on Mn^(2+)-catalytic ozonation conditioning:Feasibility study and microbial mechanisms 被引量:2
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作者 Haozhe Huang Tingting Wei +6 位作者 Hui Wang Bing Xue Sisi Chen Xiankai Wang Haibin Wu Bin Dong Zuxin Xu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第1期185-197,共13页
To improve the sludge conditioning efficiency without increasing the ozone dose,an in-situ sludge reduction process based on Mn^(2+)-catalytic ozonation conditioning was proposed.Using ozone conditioning alone as a co... To improve the sludge conditioning efficiency without increasing the ozone dose,an in-situ sludge reduction process based on Mn^(2+)-catalytic ozonation conditioning was proposed.Using ozone conditioning alone as a control,a lab-scale sequencing batch reactor coupled with ozonated sludge recycle was evaluated for its operating performance at an ozone dose of 75 mg O_(3)/g VSS and 1.5 mmol/L Mn^(2+)addition.The results showed a 39.4%reduction in MLSS and an observed sludge yield of 0.236 kg MLSS/kg COD for the O_(3)+Mn^(2+)group compared to the O_(3)group (15.3%and 0.292 kg MLSS/kg COD),accompanied by better COD,NH_(4)^(+)-N,TN and TP removal,improved effluent SS and limited impact on excess sludge properties.Subsequently,activity tests,BIOLOG ECO microplates and 16S rRNA sequencing were applied to elucidate the changing mechanisms of Mn^(2+)-catalytic ozonation related to microbial action:(1) Dehydrogenase activity reached a higher peak.(2) Microbial utilization of total carbon sources had an elevated effect,up to approximately 18%,and metabolic levels of six carbon sources were also increased,especially for sugars and amino acids most pronounced.(3) The abundance of Defluviicoccus under the phylum Proteobacteria was enhanced to 12.0%and dominated in the sludge,they had strong hydrolytic activity and metabolic capacity.Denitrifying bacteria of the genus Ferruginibacter also showed an abundance of 7.6%,they contributed to the solubilization and reduction of sludge biomass.These results could guide researchers to further reduce ozonation conditioning costs,improve sludge management and provide theoretical support. 展开更多
关键词 Activated sludge In-situ reduction Catalytic ozonation conditioning Dehydrogenase activity Carbon source utilization Microbial community
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Distributed power conditioning unit of large-scale space solar power station 被引量:1
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作者 Xintong LI Jianwei MI +2 位作者 Yiqun ZHANG Guanheng FAN Jie DU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第8期421-434,共14页
In this paper,a multi-bus distributed Power Conditioning Unit(PCU)is proposed for the Space Solar Power Station with large scale photovoltaic(PV)array and power levels reaching MW level.In this unit,there are multiple... In this paper,a multi-bus distributed Power Conditioning Unit(PCU)is proposed for the Space Solar Power Station with large scale photovoltaic(PV)array and power levels reaching MW level.In this unit,there are multiple independent PV arrays.In each PV array,there are multiple independent PV subarrays.In this paper,a V-P droop control method with adaptive droop coefficient is proposed,which modifies the droop intercept based on the bus voltage deviation and the power per unit value of the PV array.This method ensures the accuracy of bus voltage and achieves proportional distribution of power between PV arrays based on the proposed topology structure in this paper.When the load changes or the output power of the PV array fluctuates,this method can ensure that power is distributed proportionally.The principle and control method of the proposed droop control method is analyzed in this paper.The effectiveness of the method is verified through MATLAB/Simulink simulation and experiment.Simulation and experimental results show that the proposed method can achieve power distributed proportionally when load changes and PV output power fluctuates,reduce bus voltage error caused by line impedance and differences in rated power of different PV arrays,and improve the performance of PV power generation system applied to space. 展开更多
关键词 Space Solar Power Station Photovoltaics Droop control DC confluence Power conditioning unit
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Tailoring Classical Conditioning Behavior in TiO_(2) Nanowires:ZnO QDs-Based Optoelectronic Memristors for Neuromorphic Hardware 被引量:1
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作者 Wenxiao Wang Yaqi Wang +5 位作者 Feifei Yin Hongsen Niu Young-Kee Shin Yang Li Eun-Seong Kim Nam-Young Kim 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第7期265-280,共16页
Neuromorphic hardware equipped with associative learn-ing capabilities presents fascinating applications in the next generation of artificial intelligence.However,research into synaptic devices exhibiting complex asso... Neuromorphic hardware equipped with associative learn-ing capabilities presents fascinating applications in the next generation of artificial intelligence.However,research into synaptic devices exhibiting complex associative learning behaviors is still nascent.Here,an optoelec-tronic memristor based on Ag/TiO_(2) Nanowires:ZnO Quantum dots/FTO was proposed and constructed to emulate the biological associative learning behaviors.Effective implementation of synaptic behaviors,including long and short-term plasticity,and learning-forgetting-relearning behaviors,were achieved in the device through the application of light and electrical stimuli.Leveraging the optoelectronic co-modulated characteristics,a simulation of neuromorphic computing was conducted,resulting in a handwriting digit recognition accuracy of 88.9%.Furthermore,a 3×7 memristor array was constructed,confirming its application in artificial visual memory.Most importantly,complex biological associative learning behaviors were emulated by mapping the light and electrical stimuli into conditioned and unconditioned stimuli,respectively.After training through associative pairs,reflexes could be triggered solely using light stimuli.Comprehen-sively,under specific optoelectronic signal applications,the four features of classical conditioning,namely acquisition,extinction,recovery,and generalization,were elegantly emulated.This work provides an optoelectronic memristor with associative behavior capabilities,offering a pathway for advancing brain-machine interfaces,autonomous robots,and machine self-learning in the future. 展开更多
关键词 Artificial intelligence Classical conditioning Neuromorphic computing Artificial visual memory Optoelectronic memristors ZnO Quantum dots
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Autologous hematopoietic stem cell transplantation conditioning regimens and chimeric antigen receptor T cell therapy in various diseases 被引量:1
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作者 Shahzaib Maqbool Maryam Farhan Baloch +2 位作者 Muhammad Abdul Khaliq Khan Azeem Khalid Kiran Naimat 《World Journal of Transplantation》 2024年第1期32-41,共10页
Conditioning regimens employed in autologous stem cell transplantation have been proven useful in various hematological disorders and underlying malignancies;however,despite being efficacious in various instances,nega... Conditioning regimens employed in autologous stem cell transplantation have been proven useful in various hematological disorders and underlying malignancies;however,despite being efficacious in various instances,negative consequences have also been recorded.Multiple conditioning regimens were extracted from various literature searches from databases like PubMed,Google scholar,EMBASE,and Cochrane.Conditioning regimens for each disease were compared by using various end points such as overall survival(OS),progression free survival(PFS),and leukemia free survival(LFS).Variables were presented on graphs and analyzed to conclude a more efficacious conditioning regimen.In multiple myeloma,the most effective regimen was high dose melphalan(MEL)given at a dose of 200/mg/m2.The comparative results of acute myeloid leukemia were presented and the regimens that proved to be at an admirable position were busulfan(BU)+MEL regarding OS and BU+VP16 regarding LFS.In case of acute lymphoblastic leukemia(ALL),BU,fludarabine,and etoposide(BuFluVP)conferred good disease control not only with a paramount improvement in survival rate but also low risk of recurrence.However,for ALL,chimeric antigen receptor(CAR)T cell therapy was preferred in the context of better OS and LFS.With respect to Hodgkin’s lymphoma,mitoxantrone(MITO)/MEL overtook carmustine,VP16,cytarabine,and MEL in view of PFS and vice versa regarding OS.Non-Hodgkin’s lymphoma patients were administered MITO(60 mg/m2)and MEL(180 mg/m2)which showed promising results.Lastly,amyloidosis was considered,and the regimen that proved to be competent was MEL 200(200 mg/m2).This review article demonstrates a comparison between various conditioning regimens employed in different diseases. 展开更多
关键词 conditioning regimens Multiple myeloma LYMPHOMA HODGKIN NON-HODGKIN Acute leukemia
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Investigating effect of coke porosity on blast furnace performance based on multi-physical fields
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作者 Ji Chen Zhao Lei +3 位作者 Zhe Yao Li Wang Qiang Ling Ping Cui 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2024年第2期357-367,共11页
Reducing coke use is an effective measure to reduce carbon emission and energy consumption in the blast furnace(BF)ironmaking.Essentially,BF is a high-temperature moving bed reactor,where complex physical transformati... Reducing coke use is an effective measure to reduce carbon emission and energy consumption in the blast furnace(BF)ironmaking.Essentially,BF is a high-temperature moving bed reactor,where complex physical transformations coupled with complicated reactions occur.This makes it challenging to investigate the factors determining BF performance with the conventional method.A multi-physical field coupling mathematical model of BF was thus developed to describe its mass and heat transfer as well as its intrinsic reactions.Then,the proposed model was validated with the production data.Under coupling conditions,influences of dominating reactions on BF performance(temperature distribution,gas distribution,iron formation reaction,and direct reduction degree)were revealed.The results indicated that coke combustion,indirect reduction,and direct reduction of iron ore mainly took place nearby the shaft tuyere,cohesive zone,and dripping zone,respectively.Besides,the rate of coke solution loss reaction was increased with the rising coke porosity in the cohesive zone.Considering the effect of coke porosity on the efficiency and stability of BF,the coke porosity of 0.42 was regarded as a reasonable value. 展开更多
关键词 Blast furnace Mathematical model multi-physical field Simulation Coke porosity
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Design and high-power testing of offline conditioning cavity for CiADS RFQ high-power coupler
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作者 Ruo-Xu Wang Yuan He +6 位作者 Long-Bo Shi Chen-Xing Li Zong-Heng Xue Tian-Cai Jiang Xian-Bo Xu Lie-Peng Sun Zhou-Li Zhang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第9期18-27,共10页
To validate the design rationality of the power coupler for the RFQ cavity and minimize cavity contamination,we designed a low-loss offline conditioning cavity and conducted high-power testing.This offline cavity feat... To validate the design rationality of the power coupler for the RFQ cavity and minimize cavity contamination,we designed a low-loss offline conditioning cavity and conducted high-power testing.This offline cavity features two coupling ports and two tuners,operating at a frequency of 162.5 MHz with a tuning range of 3.2 MHz.Adjusting the installation angle of the coupling ring and the insertion depth of the tuner helps minimize cavity losses.We performed electromagnetic structural and multiphysics simulations,revealing a minimal theoretical power loss of 4.3%.However,when the cavity frequency varied by110 kHz,theoretical power losses increased to10%,necessitating constant tuner adjustments during conditioning.Multiphysics simulations indicated that increased cavity temperature did not affect frequency variation.Upon completion of the offline high-power conditioning platform,we measured the transmission performance,revealing a power loss of 6.3%,exceeding the theoretical calculation.Conditioning utilized efficient automatic range scanning and standing wave resonant methods.To fully condition the power coupler,a 15°phase difference between two standing wave points in the condition-ing system was necessary.Notably,the maximum continuous wave power surpassed 20 kW,exceeding the expected target. 展开更多
关键词 RFQ cavity Power coupler Offline conditioning Resonant cavity
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Actuator fault diagnosis and severity identification of turbofan engines for steady-state and dynamic conditions 被引量:1
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作者 Yuzhi CHEN Weigang ZHANG +4 位作者 Zhiwen ZHAO Elias TSOUTSANIS Areti MALKOGIANNI Yanhua MA Linfeng GOU 《Chinese Journal of Aeronautics》 2025年第1期427-443,共17页
Actuator faults can be critical in turbofan engines as they can lead to stall,surge,loss of thrust and failure of speed control.Thus,fault diagnosis of gas turbine actuators has attracted considerable attention,from b... Actuator faults can be critical in turbofan engines as they can lead to stall,surge,loss of thrust and failure of speed control.Thus,fault diagnosis of gas turbine actuators has attracted considerable attention,from both academia and industry.However,the extensive literature that exists on this topic does not address identifying the severity of actuator faults and focuses mainly on actuator fault detection and isolation.In addition,previous studies of actuator fault identification have not dealt with multiple concurrent faults in real time,especially when these are accompanied by sudden failures under dynamic conditions.This study develops component-level models for fault identification in four typical actuators used in high-bypass ratio turbofan engines under both dynamic and steady-state conditions and these are then integrated with the engine performance model developed by the authors.The research results reported here present a novel method of quantifying actuator faults using dynamic effect compensation.The maximum error for each actuator is less than0.06%and 0.07%,with average computational time of less than 0.0058 s and 0.0086 s for steady-state and transient cases,respectively.These results confirm that the proposed method can accurately and efficiently identify concurrent actuator fault for an engine operating under either transient or steady-state conditions,even in the case of a sudden malfunction.The research results emonstrate the potential benefit to emergency response capabilities by introducing this method of monitoring the health of aero engines. 展开更多
关键词 Turbofan engines Actuators Real time systems Fault identification Steady-state conditions Dynamic conditions
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Operating Parameters of the District Heating Substation Cooperating With the Installation of Technological Air Conditioning With High Efficiency of Heat Recovery
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作者 Żarski Kazimierz Kryża Mariusz 《Chinese Business Review》 2024年第1期1-12,共12页
The article analyses the problem of determining the operating parameters of the district heating substation cooperating with the air heating system in technological air conditioning systems equipped with heat exchange... The article analyses the problem of determining the operating parameters of the district heating substation cooperating with the air heating system in technological air conditioning systems equipped with heat exchangers with high efficiency of heat recovery.Attention was paid to the correct selection of heat exchangers for the heat output balance depending on the heat recovery protection algorithms against a drop in the temperature of the heat transfer surface below 0℃.Critical parameters were determined in Polish climatic conditions,at which the operation of the heat recovery exchanger in the air conditioning system is switched off or limited.It has been proven that the proper functioning of the district heating substation cooperating with the installation of air conditioning with high heat recovery efficiency requires the use of two heat exchangers with different characteristics,equipped with properly selected temperature control systems.The optimal model of cooperation between the technological air conditioning system and the heating substation was also indicated. 展开更多
关键词 ventilation of operating theatre air conditioning flow control in heating circuit
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