In the structural reliability analysis,the first-order reliability method(FORM)often yields significant errors when addressing nonlinear problems.Although the second-order reliability method(SORM)can provide higher ac...In the structural reliability analysis,the first-order reliability method(FORM)often yields significant errors when addressing nonlinear problems.Although the second-order reliability method(SORM)can provide higher accuracy,the additional computation of the Hessian matrix leads to lower computational efficiency.Additionally,when the dimensionality of the random variables is high,the approximation formula of SORM can result in larger errors.To address these issues,a structural reliability analysis method based on Kriging and spherical cap area integral is proposed.Firstly,this method integrates FORM with the quasi-Newton algorithm Broyden-Fletcher-Goldfarb-Shanno(BFGS),trains the Kriging model by using sample points from the algorithm’s iteration process,and combines the Kriging model with gradient information to approximate the Hessian matrix.Then,the failure surface is approximated as a rotating paraboloid,utilizing the spherical cap to replace the complex surface.For the n-dimensional case,the hyperspherical cap area expression is combined with the integral method to calculate the failure probability.Finally,the method is validated through three examples,demonstrating improved computational accuracy and efficiency compared to traditional methods.展开更多
In this study,an improved integrated radial basis function with nonuniform shape parameter is introduced.The proposed shape parameter varies in each support domain and is defined byθ=1/d_(max),where d_(max)is the max...In this study,an improved integrated radial basis function with nonuniform shape parameter is introduced.The proposed shape parameter varies in each support domain and is defined byθ=1/d_(max),where d_(max)is the maximum distance of any pair of nodes in the support domain.The proposed method is verified and shows good performance.The results are stable and accurate with any number of nodes and an arbitrary nodal distribution.Notably,the support domain should be large enough to obtain accurate results.This method is then applied for transient analysis of curved shell structures made from functionally graded materials with complex geometries.Through several numerical examples,the accuracy of the proposed approach is demonstrated and discussed.Additionally,the influence of various factors on the dynamic behavior of the structures,including the power-law index,different materials,loading conditions,and geometrical parameters of the structures,was investigated.展开更多
This paper studies the sensing base station(SBS)that has great potential to improve the safety of vehicles and pedestrians on roads.SBS can detect the targets on the road with communication signals using the integrate...This paper studies the sensing base station(SBS)that has great potential to improve the safety of vehicles and pedestrians on roads.SBS can detect the targets on the road with communication signals using the integrated sensing and communication(ISAC)technique.Compared with vehicle-mounted radar,SBS has a better sensing field due to its higher deployment position,which can help solve the problem of sensing blind areas.In this paper,key technologies of SBS are studied,including the beamforming algorithm,beam scanning scheme,and interference cancellation algorithm.To transmit and receive ISAC signals simultaneously,a double-coupling antenna array is applied.The free detection beam and directional communication beam are proposed for joint communication and sensing to meet the requirements of beamwidth and pointing directions.The joint timespace-frequency domain division multiple access algorithm is proposed to cancel the interference of SBS,including multiuser interference and duplex interference between sensing and communication.Finally,the sensing and communication performance of SBS under the industrial scientific medical power limitation is analyzed and simulated.Simulation results show that the communication rate of SBS can reach over 100 Mbps and the range of sensing and communication can reach about 500 m.展开更多
Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,mili...Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work environment.Methods:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise regimen.Omics profiles post-vs.pre-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics modalities.Results:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of samples.The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands.The urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid balance.In saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory infection.Conclusions:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.展开更多
In order to improve the detection accuracy of Doppler asymmetric spatial heterodyne(DASH)interferometer in harsh temperatures,an opto-mechanical-thermal integration analysis is carried out.Firstly,the correlation betw...In order to improve the detection accuracy of Doppler asymmetric spatial heterodyne(DASH)interferometer in harsh temperatures,an opto-mechanical-thermal integration analysis is carried out.Firstly,the correlation between the interference phase and temperature is established according to the working principle and the phase algorithm of the interferometer.Secondly,the optical mechanical thermal analysis model and thermal deformation data acquisition model are designed.The deformation data of the interference module and the imaging optical system at different temperatures are given by temperature load simulation analysis,and the phase error caused by thermal deformation is obtained by fitting.Finally,based on the wind speed error caused by thermal deformation of each component,a reasonable temperature control scheme is proposed.The results show that the interference module occupies the main cause,the temperature must be controlled within(20±0.05)℃,and the temperature control should be carried out for the temperature sensitive parts,and the wind speed error caused by the part is 3.8 m/s.The thermal drift between the magnification of the imaging optical system and the thermal drift of the relative position between the imaging optical system and the detector should occupy the secondary cause,which should be controlled within(20±2)℃,and the wind speed error caused by the part is 3.05 m/s.In summary,the wind measurement error caused by interference module,imaging optical system,and the relative position between the imaging optical system and the detector can be controlled within 6.85 m/s.The analysis and temperature control schemes presented in this paper can provide theoretical basis for DASH interferometer engineering applications.展开更多
To enhance the safety of road traffic operations,this paper proposed a model based on stacking integrated learning utilizing American road traffic accident statistics.Initially,the process involved data cleaning,trans...To enhance the safety of road traffic operations,this paper proposed a model based on stacking integrated learning utilizing American road traffic accident statistics.Initially,the process involved data cleaning,transformation,and normalization.Subsequently,various classification models were constructed,including logistic regression,k-nearest neighbors,gradient boosting,decision trees,AdaBoost,and extra trees models.Evaluation metrics such as accuracy,precision,recall,F1 score,and Hamming loss were employed.Upon analysis,the passive-aggressive classifier model exhibited superior comprehensive indices compared to other models.Based on the model’s output results,an in-depth examination of the factors influencing traffic accidents was conducted.Additionally,measures and suggestions aimed at reducing the incidence of severe traffic accidents were presented.These findings served as a valuable reference for mitigating the occurrence of traffic accidents.展开更多
Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering va...Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering valuable insights into tumor biology and potential treatment strategies.Methods:We conducted a comprehensive multi-omics analysis of 132 patients with American Joint Committee on Cancer(AJCC)stage III TNBC,comprising 36 long-term survivors(RFS≥8 years),62 moderate-term survivors(RFS:3-8 years),and 34 short-term survivors(RFS<3 years).Analyses investigated clinicopathological factors,whole-exome sequencing,germline mutations,copy number alterations(CNAs),RNA sequences,and metabolomic profiles.Results:Long-term survivors exhibited fewer metastatic regional lymph nodes,along with tumors showing reduced stromal fibrosis and lower Ki67 index.Molecularly,these tumors exhibited multiple alterations in genes related to homologous recombination repair,with higher frequencies of germline mutations and somatic CNAs.Additionally,tumors from long-term survivors demonstrated significant downregulation of the RTK-RAS signaling pathway.Metabolomic profiling revealed decreased levels of lipids and carbohydrate,particularly those involved in glycerophospholipid,fructose,and mannose metabolism,in long-term survival group.Multivariate Cox analysis identified fibrosis[hazard ratio(HR):12.70,95%confidence interval(95%CI):2.19-73.54,P=0.005]and RAC1copy number loss/deletion(HR:0.22,95%CI:0.06-0.83,P=0.026)as independent predictors of RFS.Higher fructose/mannose metabolism was associated with worse overall survival(HR:1.30,95%CI:1.01-1.68,P=0.045).Our findings emphasize the association between biological determinants and prolonged survival in patients with TNBC.Conclusions:Our study systematically identified the key molecular and metabolic features associated with prolonged survival in AJCC stage III TNBC,suggesting potential therapeutic targets to improve patient outcomes.展开更多
Integrated data and energy transfer(IDET)enables the electromagnetic waves to transmit wireless energy at the same time of data delivery for lowpower devices.In this paper,an energy harvesting modulation(EHM)assisted ...Integrated data and energy transfer(IDET)enables the electromagnetic waves to transmit wireless energy at the same time of data delivery for lowpower devices.In this paper,an energy harvesting modulation(EHM)assisted multi-user IDET system is studied,where all the received signals at the users are exploited for energy harvesting without the degradation of wireless data transfer(WDT)performance.The joint IDET performance is then analysed theoretically by conceiving a practical time-dependent wireless channel.With the aid of the AO based algorithm,the average effective data rate among users are maximized by ensuring the BER and the wireless energy transfer(WET)performance.Simulation results validate and evaluate the IDET performance of the EHM assisted system,which also demonstrates that the optimal number of user clusters and IDET time slots should be allocated,in order to improve the WET and WDT performance.展开更多
To better clarify the impact of the integration of education,science and technology,and talent on the cultivation of top-notch innovative talents in universities,this study adopts the fuzzy-set Qualitative Comparative...To better clarify the impact of the integration of education,science and technology,and talent on the cultivation of top-notch innovative talents in universities,this study adopts the fuzzy-set Qualitative Comparative Analysis(fsQCA)method.Using 23 universities in China as the research sample,the findings reveal that:(1)none of the three individual factors,education,science and technology,or talent can independently constitute either a necessary or sufficient condition for high-quality cultivation of top-notch innovative talents;(2)the sufficient condition for achieving high-quality cultivation lies in specific configurations of multiple condition variables;(3)five configurations were identified,from which three distinct paths toward achieving high-quality cultivation were derived.Accordingly,different universities can,based on their own resource endowments and local contexts,select appropriate cultivation paths to effectively enhance the quality of top-notch innovative talent training.展开更多
Around the world,there has been a notable shift toward the use of renewable energy technology due to the growing demand for energy and the ongoing depletion of conventional resources,such as fossil fuels.Following thi...Around the world,there has been a notable shift toward the use of renewable energy technology due to the growing demand for energy and the ongoing depletion of conventional resources,such as fossil fuels.Following this worldwide trend,Brunei’s government has initiated several strategic programs aimed at encouraging the establishment of energy from renewable sources in the nation’s energy mix.These initiatives are designed not only to support environmental sustainability but also to make energy from renewable sources increasingly competitive in comparison to more conventional energy sources like gas and oil,which have historically dominated Brunei’s energy market.The optimization of a hybrid energy system that combines diesel generators,solar photovoltaic(PV)panels,and the national power grid is the focus of this study.The objective is to identify the most cost-effective and environmentally sustainable configuration that can reliably meet local energy demands.During optimization,several configuration was tried and tested,including only grid,PV and Grid and PV-generator.HOMER(Hybrid Optimization of Multiple Energy Resources)software,a popular simulation tool that makes it possible to simulate and analyze hybrid energy systems,is utilized in the optimization process.Inside the HOMER Pro optimization,various system configuration is taken into account for the optimization.While simulating,it takes into account different combinations of components such as solar panels,wind turbines and batteries.Later on,it is being ranked by different factors such as net present cost(NPC),Cost of Energy(COE),etc.A comprehensive techno-economic research is carried out to evaluate various system configurations,considering key performance indicators such as total energy generation cost,operational expenditure,and greenhouse gas emissions.The results provide valuable insights into how renewable-based hybrid systems can reduce environmental impact while maintaining economic viability,supporting Brunei’s broader goals of energy diversification and sustainability.The study also emphasizes how such hybrid systems could be scaled for off-grid and rural populations in Brunei,where a dependable electricity supply is still a problem.Furthermore,sensitivity analyses were performed to evaluate the effects of variations in solar irradiation,load demand,and fuel prices on the overall system performance.Policymakers and energy planners can use these insights to help them make data-driven decisions about future investments in infrastructure for renewable energy.展开更多
Hematopoiesis originates in the yolk sac,which forms prior to the establishment of blood circulation and exhibits distinct developmental processes between primates and mice.Despite increasing appreciation of yolk sac ...Hematopoiesis originates in the yolk sac,which forms prior to the establishment of blood circulation and exhibits distinct developmental processes between primates and mice.Despite increasing appreciation of yolk sac hematopoiesis for its lifelong contribution to the adult hematopoietic system and its regulatory roles in organogenesis,cross-species differences,particularly before the onset of blood circulation,remain incompletely understood.In this study,we constructed an integrative cross-species transcriptome atlas of pre-circulation hematopoiesis in humans,monkeys(Macaca fascicularis),and mice.This analysis identified conserved populations between primates and mice,while also revealing more differentiated myeloid,erythroid,and megakaryocytic lineages in pre-circulation primates compared to mice.Specifically,SPP1-expressingmacrophageswere detected in primates before the onset of blood circulation but were absent in mice.Cell-cell communication analysis identified CSF1+extraembryonic mesoderm cells as a potential supportive niche for macrophage generation,with ligand-receptor interactions between macrophages and other cell populations in the human yolk sac.Interestingly,pre-circulation SPP1+macrophages exhibited hallmark signatures reminiscent of a macrophage subset that positively regulates hematopoietic stem cell generation.Our findings provide a valuable cross-species resource,advancing our understanding of human pre-circulation yolk sac hematopoiesis and offering a theoretical basis for the regeneration of functional blood cells.展开更多
Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quan...Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quantum mechanics and value problems.In this paper,we first give the definition of a quasi-Cauchy type integral in complex Clifford analysis,and get the Plemelj formula for it.Second,we discuss the H?lder continuity for the Cauchy-type integral operators with values in a complex Clifford algebra.Finally,we prove the existence of solutions for a class of linear boundary value problems and give the integral representation for the solution.展开更多
Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision...Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision-making across diverse domains. Conversely, Python is indispensable for professional programming due to its versatility, readability, extensive libraries, and robust community support. It enables efficient development, advanced data analysis, data mining, and automation, catering to diverse industries and applications. However, one primary issue when using Microsoft Excel with Python libraries is compatibility and interoperability. While Excel is a widely used tool for data storage and analysis, it may not seamlessly integrate with Python libraries, leading to challenges in reading and writing data, especially in complex or large datasets. Additionally, manipulating Excel files with Python may not always preserve formatting or formulas accurately, potentially affecting data integrity. Moreover, dependency on Excel’s graphical user interface (GUI) for automation can limit scalability and reproducibility compared to Python’s scripting capabilities. This paper covers the integration solution of empowering non-programmers to leverage Python’s capabilities within the familiar Excel environment. This enables users to perform advanced data analysis and automation tasks without requiring extensive programming knowledge. Based on Soliciting feedback from non-programmers who have tested the integration solution, the case study shows how the solution evaluates the ease of implementation, performance, and compatibility of Python with Excel versions.展开更多
This study unfolds an innovative approach aiming to address the critical role of building design in global energy consumption, focusing on optimizing the Window-to-Wall Ratio (WWR), since buildings account for approxi...This study unfolds an innovative approach aiming to address the critical role of building design in global energy consumption, focusing on optimizing the Window-to-Wall Ratio (WWR), since buildings account for approximately 30% of total energy consumed worldwide. The greatest contributors to energy expenditure in buildings are internal artificial lighting and heating and cooling systems. The WWR, determined by the proportion of the building’s glazed area to its wall area, is a significant factor influencing energy efficiency and minimizing energy load. This study introduces the development of a semi-automated computer model designed to offer a real-time, interactive simulation environment, fostering improving communication and engagement between designers and owners. The said model serves to optimize both the WWR and building orientation to align with occupants’ needs and expectations, subsequently reducing annual energy consumption and enhancing the overall building energy performance. The integrated model incorporates Building Information Modeling (BIM), Virtual Reality (VR), and Energy Analysis tools deployed at the conceptual design stage, allowing for the amalgamation of owners’ inputs in the design process and facilitating the creation of more realistic and effective design strategies.展开更多
Classical Chinese characters,presented through calligraphy,seal engraving,or painting,can exhibit different aesthetics and essences of Chinese characters,making them the most important asset of the Chinese people.Call...Classical Chinese characters,presented through calligraphy,seal engraving,or painting,can exhibit different aesthetics and essences of Chinese characters,making them the most important asset of the Chinese people.Calligraphy and seal engraving,as two closely related systems in traditional Chinese art,have developed through the ages.Due to changes in lifestyle and advancements in modern technology,their original functions of daily writing and verification have gradually diminished.Instead,they have increasingly played a significant role in commercial art.This study utilizes the Evaluation Grid Method(EGM)and the Analytic Hierarchy Process(AHP)to research the key preference factors in the application of calligraphy and seal engraving imagery.Different from the traditional 5-point equal interval semantic questionnaire,this study employs a non-equal interval semantic questionnaire with a golden ratio scale,distinguishing the importance ratio of adjacent semantic meanings and highlighting the weighted emphasis on visual aesthetics.Additionally,the study uses Importance-Performance Analysis(IPA)and Technique for Order Preference by Similarity to Ideal Solution(TOPSIS)to obtain the key preference sequence of calligraphy and seal engraving culture.Plus,the Choquet integral comprehensive evaluation is used as a reference for IPA comparison.It is hoped that this study can provide cultural imagery references and research methods,injecting further creativity into industrial design.展开更多
This paper presents an improved precise integration algorithm fortransient analysis of heat transfer and some other problems. Theoriginal precise integration method is improved by means of the inve-rse accuracy analys...This paper presents an improved precise integration algorithm fortransient analysis of heat transfer and some other problems. Theoriginal precise integration method is improved by means of the inve-rse accuracy analysis so that the parameter N, which has been takenas a constant and an independent pa- rameter without consideration ofthe problems in the original method, can be generated automaticallyby the algorithm itself.展开更多
This paper presents an isogeometric boundary element method(IGABEM)for transient heat conduction analysis.The Non-Uniform Rational B-spline(NURBS)basis functions,which are used to construct the geometry of the structu...This paper presents an isogeometric boundary element method(IGABEM)for transient heat conduction analysis.The Non-Uniform Rational B-spline(NURBS)basis functions,which are used to construct the geometry of the structures,are employed to discretize the physical unknowns in the boundary integral formulations of the governing equations.Bezier extraction technique is employed to accelerate the evaluation of NURBS basis functions.We adopt a radial integration method to address the additional domain integrals.The numerical examples demonstrate the advantage of IGABEM in dimension reduction and the seamless connection between CAD and numerical analysis.展开更多
Simulated photo-degradation of fluorescent dissolved organic matter(FDOM) in Lake Baihua(BH) and Lake Hongfeng(HF) was investigated with three-dimensional excitationemission matrix(3 DEEM) fluorescence combined with t...Simulated photo-degradation of fluorescent dissolved organic matter(FDOM) in Lake Baihua(BH) and Lake Hongfeng(HF) was investigated with three-dimensional excitationemission matrix(3 DEEM) fluorescence combined with the fluorescence regional integration(FRI),parallel factor(PARAFAC) analysis,and multi-order kinetic models.In the FRI analysis,fulvic-like and humic-like materials were the main constituents for both BH-FDOM and HF-FDOM.Four individual components were identified by use of PARAFAC analysis as humic-like components(C1),fulvic-like components(C2),protein-like components(C3) and unidentified components(C4).The maximum 3 DEEM fluorescence intensity of PARAFAC components C1-C3 decreased by about 60%,70% and 90%,respectively after photo-degradation.The multi-order kinetic model was acceptable to represent the photo-degradation of FDOM with correlation coefficient(Radj2)(0.963-0.998).The photo-degradation rate constants(kn) showed differences of three orders of magnitude,from 1.09 × 10-6 to 4.02 × 10-4 min-1,and half-life of multi-order model(T1/2n)ranged from 5.26 to 64.01 min.The decreased values of fluorescence index(FI) and biogenic index(BI),the fact that of percent fluorescence response parameter of Region I(PⅠ,n) showed the greatest change ratio,followed by percent fluorescence response parameter of Region II(PⅡ,n,while the largest decrease ratio was found for C3 components,and the lowest T1/2n was observed for C3,indicated preferential degradation of protein-like materials/components derived from biological sources during photodegradation.This research on the degradation of FDOM by 3 DEEM/FRI-PARAFAC would be beneficial to understanding the photo-degradation of FD OM in natural environments and accurately predicting the environmental behaviors of contaminants in the presence of FDOM.展开更多
At 0.12 mmol/L γ-glutamyl p-nitroaniline(GGPNA),an improved integrated method was developed for kinetic analysis of γ-glutamyltransferase(GGT) reaction process and the integration with the classical initial rate met...At 0.12 mmol/L γ-glutamyl p-nitroaniline(GGPNA),an improved integrated method was developed for kinetic analysis of γ-glutamyltransferase(GGT) reaction process and the integration with the classical initial rate method to measure serum GGT.For the improved integrated method,an integrated rate equation,which used the predictor variable of reaction time and considered inhibitions by both GGPNA and products,was nonlinearly fit to GGT reaction processes.For the integration strategy,classical initial rates were estimated when GGPNA consumption percentages were below 50%;otherwise,maximal reaction rates of GGT were estimated by the improved integrated method and converted into initial rates according to the differential rate equation at 0.11 mmol/L GGPNA.The inte-gration strategy was validated using optimized GGT kinetic parameters and 10-s intervals to record reaction curves within 8.0 min.By the integration strategy,there was a linear response from 0.9 to 32.0 U/L GGT,coefficients of variation were below 3.5%for GGT from 8.0 to 32.0 U/L(n=5) ,and GGT activities in clinical sera responded linearly to their classical initial rates at 2.00 mmol/L GGPNA with an expected slope.Therefore,the integration strategy was successful in measuring GGT at 0.12 mmol/L GGPNA.展开更多
We propose a new approach to reuse the basis function evaluations in the numerical integration of isogeometric analysis.The concept of reusability of the basis functions is introduced according to their symmetrical,tr...We propose a new approach to reuse the basis function evaluations in the numerical integration of isogeometric analysis.The concept of reusability of the basis functions is introduced according to their symmetrical,translational and proportional features on both the coarse and refined levels.Based on these features and the parametric domain regularity of each basis,we classify the bases on the original level and then reuse them on the refined level,which can reduce the time for basis calculations at integration nodes.By using the sum factorization method and the mean value theorem for the integrals,a new integration method with high integral efficiency is proposed.We validate the proposed method by some structural analysis problems in domains with different dimensionality.Comparing the numerical result accuracy and the time cost of the proposed integration method with the full Gauss integration quadrature,it turns out to be very promising.展开更多
基金National Natural Science Foundation of China(No.52375236)Fundamental Research Funds for the Central Universities,China(No.23D110316)。
文摘In the structural reliability analysis,the first-order reliability method(FORM)often yields significant errors when addressing nonlinear problems.Although the second-order reliability method(SORM)can provide higher accuracy,the additional computation of the Hessian matrix leads to lower computational efficiency.Additionally,when the dimensionality of the random variables is high,the approximation formula of SORM can result in larger errors.To address these issues,a structural reliability analysis method based on Kriging and spherical cap area integral is proposed.Firstly,this method integrates FORM with the quasi-Newton algorithm Broyden-Fletcher-Goldfarb-Shanno(BFGS),trains the Kriging model by using sample points from the algorithm’s iteration process,and combines the Kriging model with gradient information to approximate the Hessian matrix.Then,the failure surface is approximated as a rotating paraboloid,utilizing the spherical cap to replace the complex surface.For the n-dimensional case,the hyperspherical cap area expression is combined with the integral method to calculate the failure probability.Finally,the method is validated through three examples,demonstrating improved computational accuracy and efficiency compared to traditional methods.
基金Ho Chi Minh City University of Technology (HCMUT), VNU-HCM for supporting this study
文摘In this study,an improved integrated radial basis function with nonuniform shape parameter is introduced.The proposed shape parameter varies in each support domain and is defined byθ=1/d_(max),where d_(max)is the maximum distance of any pair of nodes in the support domain.The proposed method is verified and shows good performance.The results are stable and accurate with any number of nodes and an arbitrary nodal distribution.Notably,the support domain should be large enough to obtain accurate results.This method is then applied for transient analysis of curved shell structures made from functionally graded materials with complex geometries.Through several numerical examples,the accuracy of the proposed approach is demonstrated and discussed.Additionally,the influence of various factors on the dynamic behavior of the structures,including the power-law index,different materials,loading conditions,and geometrical parameters of the structures,was investigated.
基金supported in part by the National Natural Science Foundation of China under Grant U21B2014,Grant 92267202,and Grant 62271081.
文摘This paper studies the sensing base station(SBS)that has great potential to improve the safety of vehicles and pedestrians on roads.SBS can detect the targets on the road with communication signals using the integrated sensing and communication(ISAC)technique.Compared with vehicle-mounted radar,SBS has a better sensing field due to its higher deployment position,which can help solve the problem of sensing blind areas.In this paper,key technologies of SBS are studied,including the beamforming algorithm,beam scanning scheme,and interference cancellation algorithm.To transmit and receive ISAC signals simultaneously,a double-coupling antenna array is applied.The free detection beam and directional communication beam are proposed for joint communication and sensing to meet the requirements of beamwidth and pointing directions.The joint timespace-frequency domain division multiple access algorithm is proposed to cancel the interference of SBS,including multiuser interference and duplex interference between sensing and communication.Finally,the sensing and communication performance of SBS under the industrial scientific medical power limitation is analyzed and simulated.Simulation results show that the communication rate of SBS can reach over 100 Mbps and the range of sensing and communication can reach about 500 m.
基金supported by the BRAVE Agile Investment from the PNNL
文摘Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work environment.Methods:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise regimen.Omics profiles post-vs.pre-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics modalities.Results:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of samples.The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands.The urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid balance.In saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory infection.Conclusions:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.
文摘In order to improve the detection accuracy of Doppler asymmetric spatial heterodyne(DASH)interferometer in harsh temperatures,an opto-mechanical-thermal integration analysis is carried out.Firstly,the correlation between the interference phase and temperature is established according to the working principle and the phase algorithm of the interferometer.Secondly,the optical mechanical thermal analysis model and thermal deformation data acquisition model are designed.The deformation data of the interference module and the imaging optical system at different temperatures are given by temperature load simulation analysis,and the phase error caused by thermal deformation is obtained by fitting.Finally,based on the wind speed error caused by thermal deformation of each component,a reasonable temperature control scheme is proposed.The results show that the interference module occupies the main cause,the temperature must be controlled within(20±0.05)℃,and the temperature control should be carried out for the temperature sensitive parts,and the wind speed error caused by the part is 3.8 m/s.The thermal drift between the magnification of the imaging optical system and the thermal drift of the relative position between the imaging optical system and the detector should occupy the secondary cause,which should be controlled within(20±2)℃,and the wind speed error caused by the part is 3.05 m/s.In summary,the wind measurement error caused by interference module,imaging optical system,and the relative position between the imaging optical system and the detector can be controlled within 6.85 m/s.The analysis and temperature control schemes presented in this paper can provide theoretical basis for DASH interferometer engineering applications.
文摘To enhance the safety of road traffic operations,this paper proposed a model based on stacking integrated learning utilizing American road traffic accident statistics.Initially,the process involved data cleaning,transformation,and normalization.Subsequently,various classification models were constructed,including logistic regression,k-nearest neighbors,gradient boosting,decision trees,AdaBoost,and extra trees models.Evaluation metrics such as accuracy,precision,recall,F1 score,and Hamming loss were employed.Upon analysis,the passive-aggressive classifier model exhibited superior comprehensive indices compared to other models.Based on the model’s output results,an in-depth examination of the factors influencing traffic accidents was conducted.Additionally,measures and suggestions aimed at reducing the incidence of severe traffic accidents were presented.These findings served as a valuable reference for mitigating the occurrence of traffic accidents.
基金supported by grants from the Medical Engineering Jiont Fund of the Fudan University(No.IDH2310117)。
文摘Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering valuable insights into tumor biology and potential treatment strategies.Methods:We conducted a comprehensive multi-omics analysis of 132 patients with American Joint Committee on Cancer(AJCC)stage III TNBC,comprising 36 long-term survivors(RFS≥8 years),62 moderate-term survivors(RFS:3-8 years),and 34 short-term survivors(RFS<3 years).Analyses investigated clinicopathological factors,whole-exome sequencing,germline mutations,copy number alterations(CNAs),RNA sequences,and metabolomic profiles.Results:Long-term survivors exhibited fewer metastatic regional lymph nodes,along with tumors showing reduced stromal fibrosis and lower Ki67 index.Molecularly,these tumors exhibited multiple alterations in genes related to homologous recombination repair,with higher frequencies of germline mutations and somatic CNAs.Additionally,tumors from long-term survivors demonstrated significant downregulation of the RTK-RAS signaling pathway.Metabolomic profiling revealed decreased levels of lipids and carbohydrate,particularly those involved in glycerophospholipid,fructose,and mannose metabolism,in long-term survival group.Multivariate Cox analysis identified fibrosis[hazard ratio(HR):12.70,95%confidence interval(95%CI):2.19-73.54,P=0.005]and RAC1copy number loss/deletion(HR:0.22,95%CI:0.06-0.83,P=0.026)as independent predictors of RFS.Higher fructose/mannose metabolism was associated with worse overall survival(HR:1.30,95%CI:1.01-1.68,P=0.045).Our findings emphasize the association between biological determinants and prolonged survival in patients with TNBC.Conclusions:Our study systematically identified the key molecular and metabolic features associated with prolonged survival in AJCC stage III TNBC,suggesting potential therapeutic targets to improve patient outcomes.
基金supported in part by the MOST Major Research and Development Project(Grant No.2021YFB2900204)the National Natural Science Foundation of China(NSFC)(Grant No.62201123,No.62132004,No.61971102)+3 种基金China Postdoctoral Science Foundation(Grant No.2022TQ0056)in part by the financial support of the Sichuan Science and Technology Program(Grant No.2022YFH0022)Sichuan Major R&D Project(Grant No.22QYCX0168)the Municipal Government of Quzhou(Grant No.2022D031)。
文摘Integrated data and energy transfer(IDET)enables the electromagnetic waves to transmit wireless energy at the same time of data delivery for lowpower devices.In this paper,an energy harvesting modulation(EHM)assisted multi-user IDET system is studied,where all the received signals at the users are exploited for energy harvesting without the degradation of wireless data transfer(WDT)performance.The joint IDET performance is then analysed theoretically by conceiving a practical time-dependent wireless channel.With the aid of the AO based algorithm,the average effective data rate among users are maximized by ensuring the BER and the wireless energy transfer(WET)performance.Simulation results validate and evaluate the IDET performance of the EHM assisted system,which also demonstrates that the optimal number of user clusters and IDET time slots should be allocated,in order to improve the WET and WDT performance.
基金2022 Philosophy and Social Sciences Research Project for Higher Education Institutions“Research on Synergistic Education Pathways Integrating Labor Education and Innovation-Entrepreneurship Education in Universities during the New Era”(Project No.:2022SJSZ1174)2024 Jiangsu University Higher Education Planning and Development Research Project“Research on the Cultivation Model of Top-notch Innovative Talents in Local High-Level Universities from the Perspective of Education-Science-Technology-Talent Integration”(Project No.:G202406)。
文摘To better clarify the impact of the integration of education,science and technology,and talent on the cultivation of top-notch innovative talents in universities,this study adopts the fuzzy-set Qualitative Comparative Analysis(fsQCA)method.Using 23 universities in China as the research sample,the findings reveal that:(1)none of the three individual factors,education,science and technology,or talent can independently constitute either a necessary or sufficient condition for high-quality cultivation of top-notch innovative talents;(2)the sufficient condition for achieving high-quality cultivation lies in specific configurations of multiple condition variables;(3)five configurations were identified,from which three distinct paths toward achieving high-quality cultivation were derived.Accordingly,different universities can,based on their own resource endowments and local contexts,select appropriate cultivation paths to effectively enhance the quality of top-notch innovative talent training.
基金funded through Deanship of Scientific Research at Northern Border University,Arar,Saudi Arabia—project number“NBU-FFR-2025-3623-06”.
文摘Around the world,there has been a notable shift toward the use of renewable energy technology due to the growing demand for energy and the ongoing depletion of conventional resources,such as fossil fuels.Following this worldwide trend,Brunei’s government has initiated several strategic programs aimed at encouraging the establishment of energy from renewable sources in the nation’s energy mix.These initiatives are designed not only to support environmental sustainability but also to make energy from renewable sources increasingly competitive in comparison to more conventional energy sources like gas and oil,which have historically dominated Brunei’s energy market.The optimization of a hybrid energy system that combines diesel generators,solar photovoltaic(PV)panels,and the national power grid is the focus of this study.The objective is to identify the most cost-effective and environmentally sustainable configuration that can reliably meet local energy demands.During optimization,several configuration was tried and tested,including only grid,PV and Grid and PV-generator.HOMER(Hybrid Optimization of Multiple Energy Resources)software,a popular simulation tool that makes it possible to simulate and analyze hybrid energy systems,is utilized in the optimization process.Inside the HOMER Pro optimization,various system configuration is taken into account for the optimization.While simulating,it takes into account different combinations of components such as solar panels,wind turbines and batteries.Later on,it is being ranked by different factors such as net present cost(NPC),Cost of Energy(COE),etc.A comprehensive techno-economic research is carried out to evaluate various system configurations,considering key performance indicators such as total energy generation cost,operational expenditure,and greenhouse gas emissions.The results provide valuable insights into how renewable-based hybrid systems can reduce environmental impact while maintaining economic viability,supporting Brunei’s broader goals of energy diversification and sustainability.The study also emphasizes how such hybrid systems could be scaled for off-grid and rural populations in Brunei,where a dependable electricity supply is still a problem.Furthermore,sensitivity analyses were performed to evaluate the effects of variations in solar irradiation,load demand,and fuel prices on the overall system performance.Policymakers and energy planners can use these insights to help them make data-driven decisions about future investments in infrastructure for renewable energy.
基金supported by the Beijing Natural Science Foundation(5222035)Beijing Nova Program(Z211100002121033,20230484407)+2 种基金National Key R&D Program of China(2021YFA0805703,2021YFA1100901,2022YFA1105700)National Natural Science Foundation of China(31930054,32100646,82370107,82270118)Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S347)。
文摘Hematopoiesis originates in the yolk sac,which forms prior to the establishment of blood circulation and exhibits distinct developmental processes between primates and mice.Despite increasing appreciation of yolk sac hematopoiesis for its lifelong contribution to the adult hematopoietic system and its regulatory roles in organogenesis,cross-species differences,particularly before the onset of blood circulation,remain incompletely understood.In this study,we constructed an integrative cross-species transcriptome atlas of pre-circulation hematopoiesis in humans,monkeys(Macaca fascicularis),and mice.This analysis identified conserved populations between primates and mice,while also revealing more differentiated myeloid,erythroid,and megakaryocytic lineages in pre-circulation primates compared to mice.Specifically,SPP1-expressingmacrophageswere detected in primates before the onset of blood circulation but were absent in mice.Cell-cell communication analysis identified CSF1+extraembryonic mesoderm cells as a potential supportive niche for macrophage generation,with ligand-receptor interactions between macrophages and other cell populations in the human yolk sac.Interestingly,pre-circulation SPP1+macrophages exhibited hallmark signatures reminiscent of a macrophage subset that positively regulates hematopoietic stem cell generation.Our findings provide a valuable cross-species resource,advancing our understanding of human pre-circulation yolk sac hematopoiesis and offering a theoretical basis for the regeneration of functional blood cells.
基金supported by the NSF of Hebei Province(A2022208007)the NSF of China(11571089,11871191)the NSF of Henan Province(222300420397)。
文摘Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quantum mechanics and value problems.In this paper,we first give the definition of a quasi-Cauchy type integral in complex Clifford analysis,and get the Plemelj formula for it.Second,we discuss the H?lder continuity for the Cauchy-type integral operators with values in a complex Clifford algebra.Finally,we prove the existence of solutions for a class of linear boundary value problems and give the integral representation for the solution.
文摘Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision-making across diverse domains. Conversely, Python is indispensable for professional programming due to its versatility, readability, extensive libraries, and robust community support. It enables efficient development, advanced data analysis, data mining, and automation, catering to diverse industries and applications. However, one primary issue when using Microsoft Excel with Python libraries is compatibility and interoperability. While Excel is a widely used tool for data storage and analysis, it may not seamlessly integrate with Python libraries, leading to challenges in reading and writing data, especially in complex or large datasets. Additionally, manipulating Excel files with Python may not always preserve formatting or formulas accurately, potentially affecting data integrity. Moreover, dependency on Excel’s graphical user interface (GUI) for automation can limit scalability and reproducibility compared to Python’s scripting capabilities. This paper covers the integration solution of empowering non-programmers to leverage Python’s capabilities within the familiar Excel environment. This enables users to perform advanced data analysis and automation tasks without requiring extensive programming knowledge. Based on Soliciting feedback from non-programmers who have tested the integration solution, the case study shows how the solution evaluates the ease of implementation, performance, and compatibility of Python with Excel versions.
文摘This study unfolds an innovative approach aiming to address the critical role of building design in global energy consumption, focusing on optimizing the Window-to-Wall Ratio (WWR), since buildings account for approximately 30% of total energy consumed worldwide. The greatest contributors to energy expenditure in buildings are internal artificial lighting and heating and cooling systems. The WWR, determined by the proportion of the building’s glazed area to its wall area, is a significant factor influencing energy efficiency and minimizing energy load. This study introduces the development of a semi-automated computer model designed to offer a real-time, interactive simulation environment, fostering improving communication and engagement between designers and owners. The said model serves to optimize both the WWR and building orientation to align with occupants’ needs and expectations, subsequently reducing annual energy consumption and enhancing the overall building energy performance. The integrated model incorporates Building Information Modeling (BIM), Virtual Reality (VR), and Energy Analysis tools deployed at the conceptual design stage, allowing for the amalgamation of owners’ inputs in the design process and facilitating the creation of more realistic and effective design strategies.
文摘Classical Chinese characters,presented through calligraphy,seal engraving,or painting,can exhibit different aesthetics and essences of Chinese characters,making them the most important asset of the Chinese people.Calligraphy and seal engraving,as two closely related systems in traditional Chinese art,have developed through the ages.Due to changes in lifestyle and advancements in modern technology,their original functions of daily writing and verification have gradually diminished.Instead,they have increasingly played a significant role in commercial art.This study utilizes the Evaluation Grid Method(EGM)and the Analytic Hierarchy Process(AHP)to research the key preference factors in the application of calligraphy and seal engraving imagery.Different from the traditional 5-point equal interval semantic questionnaire,this study employs a non-equal interval semantic questionnaire with a golden ratio scale,distinguishing the importance ratio of adjacent semantic meanings and highlighting the weighted emphasis on visual aesthetics.Additionally,the study uses Importance-Performance Analysis(IPA)and Technique for Order Preference by Similarity to Ideal Solution(TOPSIS)to obtain the key preference sequence of calligraphy and seal engraving culture.Plus,the Choquet integral comprehensive evaluation is used as a reference for IPA comparison.It is hoped that this study can provide cultural imagery references and research methods,injecting further creativity into industrial design.
基金the National Natural Science Foundation of China (No.19872016,19872017)the National Key Basic Research Special Foundation (G1999032805)the Foundation for University Key Teachers by the Ministry of Education of China
文摘This paper presents an improved precise integration algorithm fortransient analysis of heat transfer and some other problems. Theoriginal precise integration method is improved by means of the inve-rse accuracy analysis so that the parameter N, which has been takenas a constant and an independent pa- rameter without consideration ofthe problems in the original method, can be generated automaticallyby the algorithm itself.
基金funded by National Natural Science Foundation of China(NSFC)under Grant Nos.11702238,51904202,and 11902212Nanhu Scholars Program for Young Scholars of XYNU.
文摘This paper presents an isogeometric boundary element method(IGABEM)for transient heat conduction analysis.The Non-Uniform Rational B-spline(NURBS)basis functions,which are used to construct the geometry of the structures,are employed to discretize the physical unknowns in the boundary integral formulations of the governing equations.Bezier extraction technique is employed to accelerate the evaluation of NURBS basis functions.We adopt a radial integration method to address the additional domain integrals.The numerical examples demonstrate the advantage of IGABEM in dimension reduction and the seamless connection between CAD and numerical analysis.
基金financially supported by the National Natural Science Foundation of China(No.41573130)BNU Interdisciplinary Research Foundation for First-Year Doctoral Candidates(No.BNUXKJC1802)
文摘Simulated photo-degradation of fluorescent dissolved organic matter(FDOM) in Lake Baihua(BH) and Lake Hongfeng(HF) was investigated with three-dimensional excitationemission matrix(3 DEEM) fluorescence combined with the fluorescence regional integration(FRI),parallel factor(PARAFAC) analysis,and multi-order kinetic models.In the FRI analysis,fulvic-like and humic-like materials were the main constituents for both BH-FDOM and HF-FDOM.Four individual components were identified by use of PARAFAC analysis as humic-like components(C1),fulvic-like components(C2),protein-like components(C3) and unidentified components(C4).The maximum 3 DEEM fluorescence intensity of PARAFAC components C1-C3 decreased by about 60%,70% and 90%,respectively after photo-degradation.The multi-order kinetic model was acceptable to represent the photo-degradation of FDOM with correlation coefficient(Radj2)(0.963-0.998).The photo-degradation rate constants(kn) showed differences of three orders of magnitude,from 1.09 × 10-6 to 4.02 × 10-4 min-1,and half-life of multi-order model(T1/2n)ranged from 5.26 to 64.01 min.The decreased values of fluorescence index(FI) and biogenic index(BI),the fact that of percent fluorescence response parameter of Region I(PⅠ,n) showed the greatest change ratio,followed by percent fluorescence response parameter of Region II(PⅡ,n,while the largest decrease ratio was found for C3 components,and the lowest T1/2n was observed for C3,indicated preferential degradation of protein-like materials/components derived from biological sources during photodegradation.This research on the degradation of FDOM by 3 DEEM/FRI-PARAFAC would be beneficial to understanding the photo-degradation of FD OM in natural environments and accurately predicting the environmental behaviors of contaminants in the presence of FDOM.
基金Project supported by the National Natural Science Foundation of China (No.30200266)the Program for New Century Excellent Talents in University of Ministry of Education of China(No.NCET-09-928)
文摘At 0.12 mmol/L γ-glutamyl p-nitroaniline(GGPNA),an improved integrated method was developed for kinetic analysis of γ-glutamyltransferase(GGT) reaction process and the integration with the classical initial rate method to measure serum GGT.For the improved integrated method,an integrated rate equation,which used the predictor variable of reaction time and considered inhibitions by both GGPNA and products,was nonlinearly fit to GGT reaction processes.For the integration strategy,classical initial rates were estimated when GGPNA consumption percentages were below 50%;otherwise,maximal reaction rates of GGT were estimated by the improved integrated method and converted into initial rates according to the differential rate equation at 0.11 mmol/L GGPNA.The inte-gration strategy was validated using optimized GGT kinetic parameters and 10-s intervals to record reaction curves within 8.0 min.By the integration strategy,there was a linear response from 0.9 to 32.0 U/L GGT,coefficients of variation were below 3.5%for GGT from 8.0 to 32.0 U/L(n=5) ,and GGT activities in clinical sera responded linearly to their classical initial rates at 2.00 mmol/L GGPNA with an expected slope.Therefore,the integration strategy was successful in measuring GGT at 0.12 mmol/L GGPNA.
基金National Natural Science Foundation of China(Grant Nos.#51675197,#51805190).
文摘We propose a new approach to reuse the basis function evaluations in the numerical integration of isogeometric analysis.The concept of reusability of the basis functions is introduced according to their symmetrical,translational and proportional features on both the coarse and refined levels.Based on these features and the parametric domain regularity of each basis,we classify the bases on the original level and then reuse them on the refined level,which can reduce the time for basis calculations at integration nodes.By using the sum factorization method and the mean value theorem for the integrals,a new integration method with high integral efficiency is proposed.We validate the proposed method by some structural analysis problems in domains with different dimensionality.Comparing the numerical result accuracy and the time cost of the proposed integration method with the full Gauss integration quadrature,it turns out to be very promising.
