Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under ext...Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under external stimulation.However,most microrobots are currently made of a single material system and focus on fabricating a driving module as the main structure of microrobots.This hinders the integration of diverse functions in one microrobot to fulfill the complex application.Here,a multi-material and multi-module hand-microrobot based on femtosecond laser direct writing technology is proposed,which has a pH-responsive capturing module and a magnetic-responsive transportation module(MRTM).This microrobot can not only respond to pH for capturing and releasing objects,but also respond to magnetic fields for cargo delivery even with obstacles.The two responding modules of the hand-microrobot are fabricated independently,and can collaborate with each other to achieve the delivery of target objects like polystyrene(PS)microsphere(10µm)or 786-O cell by capturing,transporting,and spatial rolling.Besides,the MRTM can be locally fabricated on any prefabricated static structure,so that the whole microrobot can achieve controllable motion.This strategy is expected to be used to manipulate cells,deliver drugs for precise treatment,and environmental treatment.展开更多
早产儿视网膜病(Retinopathy of Prematurity,ROP)作为胎龄小早产儿中比较常见的一类并发症,因此及早对早产儿实施眼底筛查十分重要。但是由于早产儿对疼痛的感知能力十分敏感和持久,如果反复对早产儿进行疼痛性操作,可能影响神经细胞损...早产儿视网膜病(Retinopathy of Prematurity,ROP)作为胎龄小早产儿中比较常见的一类并发症,因此及早对早产儿实施眼底筛查十分重要。但是由于早产儿对疼痛的感知能力十分敏感和持久,如果反复对早产儿进行疼痛性操作,可能影响神经细胞损害,导致中枢神经系统永久损害与情感紊乱。因此针对实施眼底筛查的早产儿,实施镇痛管理十分必要。展开更多
基金financial support of the National Key R&D Program of China(Grant Nos.2024YFB4607402 and 2016YFA0200500)National Natural Science Foundation of China(NSFC,Grant Nos.61975213,61475164 and 61205194)International Partnership Program of Chinese Academy of Sciences(GJHZ2021130)。
文摘Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under external stimulation.However,most microrobots are currently made of a single material system and focus on fabricating a driving module as the main structure of microrobots.This hinders the integration of diverse functions in one microrobot to fulfill the complex application.Here,a multi-material and multi-module hand-microrobot based on femtosecond laser direct writing technology is proposed,which has a pH-responsive capturing module and a magnetic-responsive transportation module(MRTM).This microrobot can not only respond to pH for capturing and releasing objects,but also respond to magnetic fields for cargo delivery even with obstacles.The two responding modules of the hand-microrobot are fabricated independently,and can collaborate with each other to achieve the delivery of target objects like polystyrene(PS)microsphere(10µm)or 786-O cell by capturing,transporting,and spatial rolling.Besides,the MRTM can be locally fabricated on any prefabricated static structure,so that the whole microrobot can achieve controllable motion.This strategy is expected to be used to manipulate cells,deliver drugs for precise treatment,and environmental treatment.
文摘早产儿视网膜病(Retinopathy of Prematurity,ROP)作为胎龄小早产儿中比较常见的一类并发症,因此及早对早产儿实施眼底筛查十分重要。但是由于早产儿对疼痛的感知能力十分敏感和持久,如果反复对早产儿进行疼痛性操作,可能影响神经细胞损害,导致中枢神经系统永久损害与情感紊乱。因此针对实施眼底筛查的早产儿,实施镇痛管理十分必要。
